Abstract The use of intracortical electrodes is a crucial method for medical diagnosis and treatment and holds the promise for overcoming various neural diseases and challenges in prosthetics. The general physical and electrical function as well as the biocompatibility is extensively tested before intracortical electrodes are implanted, however, their longterm performance, is still limited through tissue scarring and electrode deterioration, and consequently a decrease in signal quality. To overcome this challenge, aspects such as materials selection, coatings, flexibility, and surgical procedures are often addressed. To date, however, a systematic, industry - compatible process for long-term functional testing of new intracortical electrodes technologies is still lacking. Implementation of a general overall in vivo testing procedure with defined quality criteria would enable reliable in vivo longterm (> 30 days) device assessment. This could reduce the risk in developing probes for long-term performance and pave the way for clinical application in patients suffering from neural diseases.
{"title":"Development of quality criteria for long-term testing of intracortical electrodes","authors":"Charlotte Sielaff, Ute Urban, Ulrich P. Froriep","doi":"10.1515/cdbme-2023-1105","DOIUrl":"https://doi.org/10.1515/cdbme-2023-1105","url":null,"abstract":"Abstract The use of intracortical electrodes is a crucial method for medical diagnosis and treatment and holds the promise for overcoming various neural diseases and challenges in prosthetics. The general physical and electrical function as well as the biocompatibility is extensively tested before intracortical electrodes are implanted, however, their longterm performance, is still limited through tissue scarring and electrode deterioration, and consequently a decrease in signal quality. To overcome this challenge, aspects such as materials selection, coatings, flexibility, and surgical procedures are often addressed. To date, however, a systematic, industry - compatible process for long-term functional testing of new intracortical electrodes technologies is still lacking. Implementation of a general overall in vivo testing procedure with defined quality criteria would enable reliable in vivo longterm (> 30 days) device assessment. This could reduce the risk in developing probes for long-term performance and pave the way for clinical application in patients suffering from neural diseases.","PeriodicalId":10739,"journal":{"name":"Current Directions in Biomedical Engineering","volume":"326 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135394557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jana Schwieger, Verena Scheper, Thomas Lenarz, Peter M. Vogt, Sarah Strauß
Abstract The cochlear implant (CI) restores hearing to patients with severe to profound sensorineural hearing loss by stimulating the spiral ganglion neurons (SGN). Due to the inner ear anatomy, a fluid-filled gap remains between the SGN and the electrode array. This gap impedes focused stimulation and thus optimized performance with the CI. Regenerating neurites may bridge this fluid-filled gap for a direct nerveelectrode- link but require a supportive matrix. Spider silk might be a suitable candidate for this support. Therefore, silk fibers were tested for biocompatibility with inner ear neuronal tissue, suitability as neurite outgrowth matrix and applicability to the CI-electrode array. Dragline silk from female Trichonephila spiders was woven around a frame and autoclaved. Spiral ganglia of young rats were prepared, cut and placed in a drop of medium on the parallel silk fibers for pre-cultivation to support adherence before remaining medium was added. After 5d of cultivation, cells were fixed and immunocytologically stained. For CIapplication, silk was wrapped around a silicone dummy and a one-sided spacer. Opposite the spacer, alginate-hydrogel was applied for silk-fixation and -shielding. After gelation, silk loops were cut in the middle to form protruding threads. Cells showed a high degree of migration and neurite regeneration along the silk fibers and in some cases the outgrown neurites directly contacted the silk. It was possible to fix the silk to the dummy as protruding fibers. The tested spider silk is compatible with the inner ear tissue in culture, supports cell growth and seems to be an attractive material for neurite contacting. Application to the CI as protruding fibers is possible, making it a promising candidate for structural support to bridge the nerve-electrode-gap.
{"title":"Auditory Neurons on the Silk Road – spider silk for bridging the nerve-electrode-gap","authors":"Jana Schwieger, Verena Scheper, Thomas Lenarz, Peter M. Vogt, Sarah Strauß","doi":"10.1515/cdbme-2023-1062","DOIUrl":"https://doi.org/10.1515/cdbme-2023-1062","url":null,"abstract":"Abstract The cochlear implant (CI) restores hearing to patients with severe to profound sensorineural hearing loss by stimulating the spiral ganglion neurons (SGN). Due to the inner ear anatomy, a fluid-filled gap remains between the SGN and the electrode array. This gap impedes focused stimulation and thus optimized performance with the CI. Regenerating neurites may bridge this fluid-filled gap for a direct nerveelectrode- link but require a supportive matrix. Spider silk might be a suitable candidate for this support. Therefore, silk fibers were tested for biocompatibility with inner ear neuronal tissue, suitability as neurite outgrowth matrix and applicability to the CI-electrode array. Dragline silk from female Trichonephila spiders was woven around a frame and autoclaved. Spiral ganglia of young rats were prepared, cut and placed in a drop of medium on the parallel silk fibers for pre-cultivation to support adherence before remaining medium was added. After 5d of cultivation, cells were fixed and immunocytologically stained. For CIapplication, silk was wrapped around a silicone dummy and a one-sided spacer. Opposite the spacer, alginate-hydrogel was applied for silk-fixation and -shielding. After gelation, silk loops were cut in the middle to form protruding threads. Cells showed a high degree of migration and neurite regeneration along the silk fibers and in some cases the outgrown neurites directly contacted the silk. It was possible to fix the silk to the dummy as protruding fibers. The tested spider silk is compatible with the inner ear tissue in culture, supports cell growth and seems to be an attractive material for neurite contacting. Application to the CI as protruding fibers is possible, making it a promising candidate for structural support to bridge the nerve-electrode-gap.","PeriodicalId":10739,"journal":{"name":"Current Directions in Biomedical Engineering","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135394558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bernhard Laufer, Sabine Krueger-Ziolek, Nour Aldeen Jalal, Knut Moeller, Paul D. Docherty, Fabian Hoeflinger, Leonhard Reindl
Abstract Many researchers have postulated inexpensive methods to estimate respiratory volumes from respirationinduced movements of the upper body. In the development of smart garments, the number and the optimal positioning of sensors is an essential aspect. Therefore, the symmetry of upper body respiratory movements was investigated based on the measurement data from a motion capture system. In the ventral central area, coefficients of determination above 0.99 regarding movements of symmetrical markers mean that sensors can be placed without restrictions in the position mirrored on the sagittal plane. This simplifies sensor positioning in a smart shirt and expands the range of applications of smart shirts for respiratory monitoring.
{"title":"Symmetry of Respiration Induced Upper Body Movements","authors":"Bernhard Laufer, Sabine Krueger-Ziolek, Nour Aldeen Jalal, Knut Moeller, Paul D. Docherty, Fabian Hoeflinger, Leonhard Reindl","doi":"10.1515/cdbme-2023-1120","DOIUrl":"https://doi.org/10.1515/cdbme-2023-1120","url":null,"abstract":"Abstract Many researchers have postulated inexpensive methods to estimate respiratory volumes from respirationinduced movements of the upper body. In the development of smart garments, the number and the optimal positioning of sensors is an essential aspect. Therefore, the symmetry of upper body respiratory movements was investigated based on the measurement data from a motion capture system. In the ventral central area, coefficients of determination above 0.99 regarding movements of symmetrical markers mean that sensors can be placed without restrictions in the position mirrored on the sagittal plane. This simplifies sensor positioning in a smart shirt and expands the range of applications of smart shirts for respiratory monitoring.","PeriodicalId":10739,"journal":{"name":"Current Directions in Biomedical Engineering","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135394563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ornella Tortorici, Alireza Abbasimoshaei, Thorsten A. Kern, Arndt F. Schilling
Abstract Home rehabilitation is a great complement to inpatient rehabilitation, because it allows for more regular training, especially in rural areas, where the access to physiotherapists is limited. However, unsupervised training carries the risk of deviation from the prescribed protocol. An obvious solution is to introduce a technical means for rehabilitation and continuous monitoring of performance. This paper presents a robotic system for rehabilitation of three degrees of freedom of the wrist independently, implemented with only one actuator, optimizing the design and size of the system. The device provides measurements of joint torque-position dependence, allowing objective assessment of mechanical impedance and range of motion to evaluate the progress of rehabilitation. Derived from research on haptic devices, a measurement method was implemented to measure hand impedance in the high frequency range between 100 and 200 Hz using a combination of exciters and accelerometers in the handles. This allows continuous monitoring of gripping forces without the need for complex contact-based force sensors. In collaboration between the authors’ technical and medical universities, a set of two-level passive and active safety measures was implemented to ensure the safety of the system’s users. Therefore, the presented system shows the potential to evaluate the mechanical impedance of the wrist at both low and high frequencies and to monitor the progress during rehabilitation. In the next step, a baseline of wrist impedance will be measured in a target group of healthy volunteers in order to prepare for studies in motion-restricted subjects.
{"title":"Design of a Flexible mechatronic system for mechanical impedance measurement of the wrist as one step towards robotic rehabilitation","authors":"Ornella Tortorici, Alireza Abbasimoshaei, Thorsten A. Kern, Arndt F. Schilling","doi":"10.1515/cdbme-2023-1164","DOIUrl":"https://doi.org/10.1515/cdbme-2023-1164","url":null,"abstract":"Abstract Home rehabilitation is a great complement to inpatient rehabilitation, because it allows for more regular training, especially in rural areas, where the access to physiotherapists is limited. However, unsupervised training carries the risk of deviation from the prescribed protocol. An obvious solution is to introduce a technical means for rehabilitation and continuous monitoring of performance. This paper presents a robotic system for rehabilitation of three degrees of freedom of the wrist independently, implemented with only one actuator, optimizing the design and size of the system. The device provides measurements of joint torque-position dependence, allowing objective assessment of mechanical impedance and range of motion to evaluate the progress of rehabilitation. Derived from research on haptic devices, a measurement method was implemented to measure hand impedance in the high frequency range between 100 and 200 Hz using a combination of exciters and accelerometers in the handles. This allows continuous monitoring of gripping forces without the need for complex contact-based force sensors. In collaboration between the authors’ technical and medical universities, a set of two-level passive and active safety measures was implemented to ensure the safety of the system’s users. Therefore, the presented system shows the potential to evaluate the mechanical impedance of the wrist at both low and high frequencies and to monitor the progress during rehabilitation. In the next step, a baseline of wrist impedance will be measured in a target group of healthy volunteers in order to prepare for studies in motion-restricted subjects.","PeriodicalId":10739,"journal":{"name":"Current Directions in Biomedical Engineering","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135427386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthias Leuchter, Stefan Siewert, Michael Stiehm, Andrea Bock, Klaus-Peter Schmitz, Sebastian Kaule, Ernst Klar
Abstract In spite of advances in the treatment of cardiovascular disease, there remains a significant need for high-quality evidence for clinical practice given the rising prevalence worldwide. Next to the increase of regulatory requirements, poor screening-to-recruitment ratios, lack of patient engagement, and long timelines for contracting and institutional review board (IRB) approval are leading to an outflow of clinical trials in the EU. Patient registries are a potentially rich source of data, especially for evaluating the course of rare diseases and effects of new treatments. In the sectors of regulatory assessments of medical devices they are greatly underused. Health-related real world data provide crucial support for regulatory decision-making, particularly post-market assessments of medical products. Registries can be used not only for observational studies, but also for conducting experimental study designs. Register-based randomized controlled trials (RRCTs) are of particular importance here, as they can combine the advantages of randomized controlled trials (RCT) and registers. The government's financial support and reduction of regulatory barriers to the implementation of registry-based RCT are incentive factors for manufacturers to let their medical devices (re-)certified. Furthermore, it is essential that the necessary criteria are already taken into account when setting up the German implant registry in order to enable future RRCTs. The presented work is an additional pleading for the use and extension of registries for all medical products.
{"title":"Randomized Registry Trials - efficient post market clinical follow-up for medical devices","authors":"Matthias Leuchter, Stefan Siewert, Michael Stiehm, Andrea Bock, Klaus-Peter Schmitz, Sebastian Kaule, Ernst Klar","doi":"10.1515/cdbme-2023-1122","DOIUrl":"https://doi.org/10.1515/cdbme-2023-1122","url":null,"abstract":"Abstract In spite of advances in the treatment of cardiovascular disease, there remains a significant need for high-quality evidence for clinical practice given the rising prevalence worldwide. Next to the increase of regulatory requirements, poor screening-to-recruitment ratios, lack of patient engagement, and long timelines for contracting and institutional review board (IRB) approval are leading to an outflow of clinical trials in the EU. Patient registries are a potentially rich source of data, especially for evaluating the course of rare diseases and effects of new treatments. In the sectors of regulatory assessments of medical devices they are greatly underused. Health-related real world data provide crucial support for regulatory decision-making, particularly post-market assessments of medical products. Registries can be used not only for observational studies, but also for conducting experimental study designs. Register-based randomized controlled trials (RRCTs) are of particular importance here, as they can combine the advantages of randomized controlled trials (RCT) and registers. The government's financial support and reduction of regulatory barriers to the implementation of registry-based RCT are incentive factors for manufacturers to let their medical devices (re-)certified. Furthermore, it is essential that the necessary criteria are already taken into account when setting up the German implant registry in order to enable future RRCTs. The presented work is an additional pleading for the use and extension of registries for all medical products.","PeriodicalId":10739,"journal":{"name":"Current Directions in Biomedical Engineering","volume":"2012 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135428645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thomas Eickner, Sabine Illner, Niels Grabow, Olga Hahn, Kirsten Peters, Brigitte Müller-Hilke, Anika Jonitz-Heincke, Rainer Bader, Tomas Fiedler
Abstract For the in vitro examination of the effects on cells and tissues of metal ions derived from implants by wear and corrosion, a system is needed to release metal ions in a controlled and sustained manner. As small concentrations may have an impact on biological systems, a corresponding slow release over a defined period of time is necessary. Here, a manufacturing method of polymeric Poly(L-lactic acid) (PLLA) films with incorporated cobalt ions via dip coating is reported. The establishment of two analytical methods for the detection and quantification of cobalt ions is shown. High performance liquid chromatography enables cobalt quantification over a concentration range of 0.33 μg/mL up to 33 μg/mL in sample solutions. Extraction and detection of cobalt ions from solvent cast PLLA-cobalt-films shows the feasibility of the manufacturing method. Initial biocompatibility tests with manufactured PLLA-cobaltfilms showed no effects on adipose derived primary mesenchymal stem cells (adMSCs).
{"title":"Manufacture and extraction of PLLA films with incorporated metal ions","authors":"Thomas Eickner, Sabine Illner, Niels Grabow, Olga Hahn, Kirsten Peters, Brigitte Müller-Hilke, Anika Jonitz-Heincke, Rainer Bader, Tomas Fiedler","doi":"10.1515/cdbme-2023-1113","DOIUrl":"https://doi.org/10.1515/cdbme-2023-1113","url":null,"abstract":"Abstract For the in vitro examination of the effects on cells and tissues of metal ions derived from implants by wear and corrosion, a system is needed to release metal ions in a controlled and sustained manner. As small concentrations may have an impact on biological systems, a corresponding slow release over a defined period of time is necessary. Here, a manufacturing method of polymeric Poly(L-lactic acid) (PLLA) films with incorporated cobalt ions via dip coating is reported. The establishment of two analytical methods for the detection and quantification of cobalt ions is shown. High performance liquid chromatography enables cobalt quantification over a concentration range of 0.33 μg/mL up to 33 μg/mL in sample solutions. Extraction and detection of cobalt ions from solvent cast PLLA-cobalt-films shows the feasibility of the manufacturing method. Initial biocompatibility tests with manufactured PLLA-cobaltfilms showed no effects on adipose derived primary mesenchymal stem cells (adMSCs).","PeriodicalId":10739,"journal":{"name":"Current Directions in Biomedical Engineering","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135428649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lucas Klauth, Andreas Mühlen, Andreas Kitzig, Edwin Naroska, Gudrun Stockmanns
Abstract In recent decades ballistocardiography (BCG) has regained popularity as a way to measure the mechanical activ- ity of the heart. In this paper we present and evaluate a new iteration of our mobile BCG measurement system. The pro- posed system uses an inertial measurement unit (IMU) placed on the carotid artery to derive the BCG. We conducted a mea- surement series to evaluate the system and to do an initial in- vestigation into whether more complex heart parameters can be derived from BCG data. The evaluation shows that heart rate (HR) and heart rate variability (HRV) calculated using BCG data, agrees well with the reference measurement and amplitudes calculated are mostly comparable in range to other papers. In conclusion, the system can reliably derive features from BCG data that can be used in further research.
{"title":"Optimization and evaluation of a mobile IMU-based ballistocardiography system","authors":"Lucas Klauth, Andreas Mühlen, Andreas Kitzig, Edwin Naroska, Gudrun Stockmanns","doi":"10.1515/cdbme-2023-1170","DOIUrl":"https://doi.org/10.1515/cdbme-2023-1170","url":null,"abstract":"Abstract In recent decades ballistocardiography (BCG) has regained popularity as a way to measure the mechanical activ- ity of the heart. In this paper we present and evaluate a new iteration of our mobile BCG measurement system. The pro- posed system uses an inertial measurement unit (IMU) placed on the carotid artery to derive the BCG. We conducted a mea- surement series to evaluate the system and to do an initial in- vestigation into whether more complex heart parameters can be derived from BCG data. The evaluation shows that heart rate (HR) and heart rate variability (HRV) calculated using BCG data, agrees well with the reference measurement and amplitudes calculated are mostly comparable in range to other papers. In conclusion, the system can reliably derive features from BCG data that can be used in further research.","PeriodicalId":10739,"journal":{"name":"Current Directions in Biomedical Engineering","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135428913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Manufacturing replicas for replacing missing or defective body parts also incorporates 3D technology, including scanning, image processing and printing. In the case of the ears, both aesthetics and functionality play a significant role. Based on these techniques, outer ear replicas were produced using 3D scans of human skulls in a rapid prototyping procedure for actual patients. Hand-held scanners delivered accurate images for post-processing of the mesh and for printing in a cost- and time efficient way. Use cases of patients demonstrate applicability, allowing the technology to be available also for the general population in the future.
{"title":"Outer ear reconstruction using 3D technology","authors":"György Wersényi, Balázs Gasz","doi":"10.1515/cdbme-2023-1001","DOIUrl":"https://doi.org/10.1515/cdbme-2023-1001","url":null,"abstract":"Abstract Manufacturing replicas for replacing missing or defective body parts also incorporates 3D technology, including scanning, image processing and printing. In the case of the ears, both aesthetics and functionality play a significant role. Based on these techniques, outer ear replicas were produced using 3D scans of human skulls in a rapid prototyping procedure for actual patients. Hand-held scanners delivered accurate images for post-processing of the mesh and for printing in a cost- and time efficient way. Use cases of patients demonstrate applicability, allowing the technology to be available also for the general population in the future.","PeriodicalId":10739,"journal":{"name":"Current Directions in Biomedical Engineering","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135889407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leonie Maleszka, Andreas Breuer-Kaiser, Marcel Schäfer, Karsten Lehn, Thomas Felderhoff
Abstract Increasing patient safety during operations is an inevitable topic in anaesthesiology. The cockpit strategy presented by Vogelsang et al. addresses this issue with elements such as closed loop communication and the use of checklists. In this paper, the use of checklists is taken up further. An AR application is presented that augments checklists for anaesthesia induction into the user’s field of view. The application is to be implemented in teaching and help prospective physicians to internalise the workflows in anaesthesiology more quickly and sustainably. A working prototype has been created and loaded onto the HoloLens 2. The prototype is being assessed and evaluated by an anaesthetist. The feedback will be included into the following development steps. The application will be further adapted to the needs and requirements of the users. In order to evaluate the usability and the user experience, students and medical professionals should test and evaluate the application repeatedly.
{"title":"Proof-of-Concept: Conceptual design and realisation of an educational augmented reality (AR) application for anaesthesia induction","authors":"Leonie Maleszka, Andreas Breuer-Kaiser, Marcel Schäfer, Karsten Lehn, Thomas Felderhoff","doi":"10.1515/cdbme-2023-1063","DOIUrl":"https://doi.org/10.1515/cdbme-2023-1063","url":null,"abstract":"Abstract Increasing patient safety during operations is an inevitable topic in anaesthesiology. The cockpit strategy presented by Vogelsang et al. addresses this issue with elements such as closed loop communication and the use of checklists. In this paper, the use of checklists is taken up further. An AR application is presented that augments checklists for anaesthesia induction into the user’s field of view. The application is to be implemented in teaching and help prospective physicians to internalise the workflows in anaesthesiology more quickly and sustainably. A working prototype has been created and loaded onto the HoloLens 2. The prototype is being assessed and evaluated by an anaesthetist. The feedback will be included into the following development steps. The application will be further adapted to the needs and requirements of the users. In order to evaluate the usability and the user experience, students and medical professionals should test and evaluate the application repeatedly.","PeriodicalId":10739,"journal":{"name":"Current Directions in Biomedical Engineering","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135393469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leo Buron, Andreas Erbslöh, Karsten Seidl, Gregor Schiele, Karsten Seidl, Zia Ur-Rehman, Christian Klaes
Abstract This paper presents a software-based Python framework for developing future AI-enhanced end-to-end Brain-Computer-Interfaces (BCI). This framework contains modules from the emulated analogue front-end and from neural signal pre-processing for invasive neural applications. These modules can be assembled into several pipeline versions for evaluation and benchmarking. The aim of this framework is to accelerate the development of BCIs due to system-wide optimizations in order to set the requirements for hardware development without prior knowledge on the basis of accuracy (recall and precision) and latency. In the next step, the pipeline can be optimised for on-chip and embedded execution.
{"title":"Deep.Neural.Signal.Pre-Processor - Towards Development of AI-enhanced End-to-End BCIs","authors":"Leo Buron, Andreas Erbslöh, Karsten Seidl, Gregor Schiele, Karsten Seidl, Zia Ur-Rehman, Christian Klaes","doi":"10.1515/cdbme-2023-1118","DOIUrl":"https://doi.org/10.1515/cdbme-2023-1118","url":null,"abstract":"Abstract This paper presents a software-based Python framework for developing future AI-enhanced end-to-end Brain-Computer-Interfaces (BCI). This framework contains modules from the emulated analogue front-end and from neural signal pre-processing for invasive neural applications. These modules can be assembled into several pipeline versions for evaluation and benchmarking. The aim of this framework is to accelerate the development of BCIs due to system-wide optimizations in order to set the requirements for hardware development without prior knowledge on the basis of accuracy (recall and precision) and latency. In the next step, the pipeline can be optimised for on-chip and embedded execution.","PeriodicalId":10739,"journal":{"name":"Current Directions in Biomedical Engineering","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135394167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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