Pub Date : 2023-03-16DOI: 10.2174/2666779702666230316093558
Vijay Sharma, Pawan Singh, L. Singh, N. Verma
Poor solubility of curcumin results in poor rate of absorption, rapid biotransformation as well as rapid rate of elimination. Due to this curcumin does not show better therapeutic effect through oral administration, to avoid poor rate of absorption, rapid biotransformation and topical drug delivery system plays a vital role. Poor solubility of CUR results in poor rate of absorption, rapid biotransformation as well as rapid rate of elimination, due to this cuircumin does not shows better therapeutic effect through oral administration, to avoid poor rate of absorption as well rapid biotransformation topical drug delivery system plays a vital role. The objective of the present work was the successful implementation of face-centered central composite design (FCCCD) to study various independent variables to develop an optimized formulation. Carbopol 934 P and menthol were considered as independent variables and their impact was determined on dependent responses like drug content, viscosity, and percent drug release by developing topical gels using 32 central composite design. Thirteen curcumin loaded topical gels were prepared employing 32 CCD. Characterization of these formulations was done by drug content, viscosity, and percent drug release. The effect of independent variable, i.e., the concentration of Carbopol 934P and menthol was determined over the dependent variables by developing a response surface methodology. Optimized batch was investigated employing design expert software by overlay plot developed by statistical software with drug content, viscosity, and percent drug release 99.34%, 82.10 cps, and 65.576% respectively. Optimized data was evaluated by formulating four validation check batches. Promising results were observed by comparing the predicted values with experimental values, which proves the validity of the optimized data. Therefore, it can be concluded that the application of face-centered central composite design is a useful statistical tool to get the optimized formulation with the least manpower, material, and money. .
{"title":"Application of Face Centered Central Composite Design in Evolution of Optimized Drug Delivery System of Golden Nutraceutical with Frame Independent Variables","authors":"Vijay Sharma, Pawan Singh, L. Singh, N. Verma","doi":"10.2174/2666779702666230316093558","DOIUrl":"https://doi.org/10.2174/2666779702666230316093558","url":null,"abstract":"\u0000\u0000Poor solubility of curcumin results in poor rate of absorption, rapid biotransformation as well as rapid rate of elimination. Due to this curcumin does not show better therapeutic effect through oral administration, to avoid poor rate of absorption, rapid biotransformation and topical drug delivery system plays a vital role.\u0000\u0000\u0000\u0000Poor solubility of CUR results in poor rate of absorption, rapid biotransformation as well as rapid rate of elimination, due to this cuircumin does not shows better therapeutic effect through oral administration, to avoid poor rate of absorption as well rapid biotransformation topical drug delivery system plays a vital role.\u0000\u0000\u0000\u0000The objective of the present work was the successful implementation of face-centered central composite design (FCCCD) to study various independent variables to develop an optimized formulation.\u0000\u0000\u0000\u0000Carbopol 934 P and menthol were considered as independent variables and their impact was determined on dependent responses like drug content, viscosity, and percent drug release by developing topical gels using 32 central composite design. Thirteen curcumin loaded topical gels were prepared employing 32 CCD. Characterization of these formulations was done by drug content, viscosity, and percent drug release.\u0000\u0000\u0000\u0000The effect of independent variable, i.e., the concentration of Carbopol 934P and menthol was determined over the dependent variables by developing a response surface methodology. Optimized batch was investigated employing design expert software by overlay plot developed by statistical software with drug content, viscosity, and percent drug release 99.34%, 82.10 cps, and 65.576% respectively. Optimized data was evaluated by formulating four validation check batches. Promising results were observed by comparing the predicted values with experimental values, which proves the validity of the optimized data.\u0000\u0000\u0000\u0000Therefore, it can be concluded that the application of face-centered central composite design is a useful statistical tool to get the optimized formulation with the least manpower, material, and money.\u0000\u0000\u0000\u0000.\u0000","PeriodicalId":10817,"journal":{"name":"Current Cosmetic Science","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81593147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-24DOI: 10.2174/2666779702666230224102043
R. Rastogi, A. Gholap, Y. C. Radhalakshmi, B. Das, A. Rangi
Sericin is a hydrophilic and adhesive protein that provides structural integrity to the silkworm cocoon. The study aimed to develop sericin isolated from Indian BV mulberry silk cocoons as a cosmetic raw material and study its sensory impact. Sericin was isolated using high-temperature and high-pressure techniques without the use of chemicals. Native and hydrolyzed sericin were studied for suitability in cosmetic formulations. Lastly, their safety was established using a primary irritation patch test in twenty-four healthy volunteers, and the impact of sericin on skin care formulation was studied. Both native and hydrolyzed sericin were studied for their application in personal care products. Native sericin was difficult to process due to its gelling behavior. Hydrolyzed sericin was readily formulated in skin lotion and was found to be stable for 3 months under accelerated conditions. Sericin and its formulations did not cause any skin irritation and were found to be well-tolerated. Formulation with 0.01% w/w hydrolyzed sericin was best accepted among the panelists. The study establishes the use of sericin isolated from mulberry silkworms as a sensory enhancer for skin care applications. Not Applicable
{"title":"Sericin: From Cocoons as a Raw Material to Cosmetics","authors":"R. Rastogi, A. Gholap, Y. C. Radhalakshmi, B. Das, A. Rangi","doi":"10.2174/2666779702666230224102043","DOIUrl":"https://doi.org/10.2174/2666779702666230224102043","url":null,"abstract":"\u0000\u0000Sericin is a hydrophilic and adhesive protein that provides structural integrity to the silkworm cocoon.\u0000\u0000\u0000\u0000The study aimed to develop sericin isolated from Indian BV mulberry silk cocoons as a cosmetic raw material and study its sensory impact.\u0000\u0000\u0000\u0000Sericin was isolated using high-temperature and high-pressure techniques without the use of chemicals. Native and hydrolyzed sericin were studied for suitability in cosmetic formulations. Lastly, their safety was established using a primary irritation patch test in twenty-four healthy volunteers, and the impact of sericin on skin care formulation was studied.\u0000\u0000\u0000\u0000Both native and hydrolyzed sericin were studied for their application in personal care products. Native sericin was difficult to process due to its gelling behavior. Hydrolyzed sericin was readily formulated in skin lotion and was found to be stable for 3 months under accelerated conditions. Sericin and its formulations did not cause any skin irritation and were found to be well-tolerated. Formulation with 0.01% w/w hydrolyzed sericin was best accepted among the panelists.\u0000\u0000\u0000\u0000The study establishes the use of sericin isolated from mulberry silkworms as a sensory enhancer for skin care applications.\u0000\u0000\u0000\u0000Not Applicable\u0000","PeriodicalId":10817,"journal":{"name":"Current Cosmetic Science","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77090127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-23DOI: 10.2174/2666779702666230223121622
S. Syed, Ajinkya Holkar, Priyanka Thore, Sakshi Vaidya
This research was conducted to make the option for chemical-based semisynthetic and synthetic hair dyes to overcome the problems with the use of synthetic dyes and the acceptance rate by the public. The work involves the use of some novel natural ingredients with novel combinations. The herbal hair dye was prepared y using various natural agents reported to possess the desired properties. The plants were collected from the herbal garden of Dr. VedprakashPatil Pharmacy College, Aurangabad & authenticated by the Dept. of Pharmacognosy. All ingredients were passed through sieves and mixed thoroughly to get a homogenous mixture; the mixture was dissolved in water and applied to the hairs for the evaluation of various parameters such as organoleptic physicochemical, patch test & stability. This Herbal hair dye prepared in the laboratory is made with all good quality materials. It was tested in the laboratory and was found to be very safe for the regular use of this herbal hair dye after several time intervals of time. All evaluation parameters were found to be within the limits as prescribed for the safe use of hair dye. The herbal hair dye was prepared by using various natural agents reported to posses the desired properties. The plants were collected from herbal garden of Dr. Vedprakash Patil Pharmacy College Aurangabad & authenticated by Dept. of Pharmacogmosy (Ref; Dr. VPPC/PCOG/2021-22/MP9875). All the ingredients were passed through sieves and mixed thoroughly to get a homogenous mixture; the mixture was dissolved in water and applied on hairs with evaluation of various parameters such as organoleptic, physicochemical, patch test & stability. The prepared herbal hair dye neither shows any side effects nor skin infections. It nourishes the skin on the scalp and hair. This herbal hair dye also aids in dandruff treatment by removing excess oil from the scalp. If such herbal dye is used frequently or regularly, it will give a manageable, fizz-free colored hair benefiting human as well as the industry. The formulation is natural in origin with effective benefits compared to the marketed formulation and cost-effective. As the process is simple, small scale cosmetic industry can make use of the technique. This Herbal hair dye prepared in the laboratory is made with all the good quality of materials. It is tested in the laboratory and was found to be very safe for the regular use of this herbal hair dye after the several time intervals of time. All the evaluation parameters were found to be within the limits as prescribed for safe use of hair dye. Herbal formulatrion was prepared and evaluated
{"title":"Formulation and Evaluation of Herbal Hair Dye: A Laboratory scale project","authors":"S. Syed, Ajinkya Holkar, Priyanka Thore, Sakshi Vaidya","doi":"10.2174/2666779702666230223121622","DOIUrl":"https://doi.org/10.2174/2666779702666230223121622","url":null,"abstract":"\u0000\u0000This research was conducted to make the option for chemical-based semisynthetic and synthetic hair dyes to overcome the problems with the use of synthetic dyes and the acceptance rate by the public. The work involves the use of some novel natural ingredients with novel combinations.\u0000\u0000\u0000\u0000The herbal hair dye was prepared y using various natural agents reported to possess the desired properties. The plants were collected from the herbal garden of Dr. VedprakashPatil Pharmacy College, Aurangabad & authenticated by the Dept. of Pharmacognosy. All ingredients were passed through sieves and mixed thoroughly to get a homogenous mixture; the mixture was dissolved in water and applied to the hairs for the evaluation of various parameters such as organoleptic physicochemical, patch test & stability.\u0000\u0000\u0000\u0000This Herbal hair dye prepared in the laboratory is made with all good quality materials. It was tested in the laboratory and was found to be very safe for the regular use of this herbal hair dye after several time intervals of time. All evaluation parameters were found to be within the limits as prescribed for the safe use of hair dye.\u0000\u0000\u0000\u0000The herbal hair dye was prepared by using various natural agents reported to posses the desired properties. The plants were collected from herbal garden of Dr. Vedprakash Patil Pharmacy College Aurangabad & authenticated by Dept. of Pharmacogmosy (Ref; Dr. VPPC/PCOG/2021-22/MP9875). All the ingredients were passed through sieves and mixed thoroughly to get a homogenous mixture; the mixture was dissolved in water and applied on hairs with evaluation of various parameters such as organoleptic, physicochemical, patch test & stability.\u0000\u0000\u0000\u0000The prepared herbal hair dye neither shows any side effects nor skin infections. It nourishes the skin on the scalp and hair. This herbal hair dye also aids in dandruff treatment by removing excess oil from the scalp. If such herbal dye is used frequently or regularly, it will give a manageable, fizz-free colored hair benefiting human as well as the industry. The formulation is natural in origin with effective benefits compared to the marketed formulation and cost-effective.\u0000As the process is simple, small scale cosmetic industry can make use of the technique.\u0000\u0000\u0000\u0000This Herbal hair dye prepared in the laboratory is made with all the good quality of materials. It is tested in the laboratory and was found to be very safe for the regular use of this herbal hair dye after the several time intervals of time. All the evaluation parameters were found to be within the limits as prescribed for safe use of hair dye.\u0000\u0000\u0000\u0000Herbal formulatrion was prepared and evaluated\u0000","PeriodicalId":10817,"journal":{"name":"Current Cosmetic Science","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89102575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-20DOI: 10.2174/2666779702666230220111250
V. Ansari, Aditya Singh, Tarique Mahmood, Farogh Ahsan, Rufaida Wasim, M. Shariq, S. Parveen, Arshiya Shamim
Ursolic acid (UA) has been utilized to improve memory-related cognitive processes and intellectual functions. This study aims to examine the ethnobotanical uses, phytochemical composition, toxicity, and central nervous system activities of UA. It promotes learning and memory and has biological effects against Alzheimer's disease, Parkinson's disease, and cognitive impairment, according to pharmacological investigations. UA did not cause any death, abnormal body weight, or pathological diseases at any of the test doses. Furthermore, no behavioral, neurotoxin, coagulation, haematological, or clinical chemistry changes were seen as a result of UA treatment. UA is also used as a cosmeceutical product to improve skin functions. This article examines all knowledge that has become available at this time for revealing the chemistry of the current has been extensively investigated based on the data, resulting in UA derivatives with improved potency, bioavailability, and stability being used to treat a number of non-communicable diseases. The pharmacological activity of UA has been exploited to improve learning and memory and treat depression, emotional stress, fatigue, anxiety, insomnia, Alzheimer’s disease, Parkinson’s disease, epilepsy, and schizophrenia. The effects of UA on the central nervous system detailed in this review. The majority of UA studies have been preclinical evaluations of cellular mechanisms in the central nervous system, and more translational clinical research is needed to assess the drug's safety and efficacy, as well as its favorable, biodistribution, which could be targeted using different pathways and administration routes. Several in vitro and in vivo studies have investigated the pharmacological properties of UA reporting neuroprotective effects and improvements in cognitive function. These effects are attributed to its antioxidant, antiapoptotic, and anti-inflammatory actions.
{"title":"Ursolic acid: Historical aspects to promising pharmacological actions for the treatment of central nervous system diseases","authors":"V. Ansari, Aditya Singh, Tarique Mahmood, Farogh Ahsan, Rufaida Wasim, M. Shariq, S. Parveen, Arshiya Shamim","doi":"10.2174/2666779702666230220111250","DOIUrl":"https://doi.org/10.2174/2666779702666230220111250","url":null,"abstract":"\u0000\u0000Ursolic acid (UA) has been utilized to improve memory-related cognitive processes and intellectual functions. This study aims to examine the ethnobotanical uses, phytochemical composition, toxicity, and central nervous system activities of UA. It promotes learning and memory and has biological effects against Alzheimer's disease, Parkinson's disease, and cognitive impairment, according to pharmacological investigations. UA did not cause any death, abnormal body weight, or pathological diseases at any of the test doses. Furthermore, no behavioral, neurotoxin, coagulation, haematological, or clinical chemistry changes were seen as a result of UA treatment. UA is also used as a cosmeceutical product to improve skin functions. This article examines all knowledge that has become available at this time for revealing the chemistry of the current has been extensively investigated based on the data, resulting in UA derivatives with improved potency, bioavailability, and stability being used to treat a number of non-communicable diseases. The pharmacological activity of UA has been exploited to improve learning and memory and treat depression, emotional stress, fatigue, anxiety, insomnia, Alzheimer’s disease, Parkinson’s disease, epilepsy, and schizophrenia. The effects of UA on the central nervous system detailed in this review. The majority of UA studies have been preclinical evaluations of cellular mechanisms in the central nervous system, and more translational clinical research is needed to assess the drug's safety and efficacy, as well as its favorable, biodistribution, which could be targeted using different pathways and administration routes. Several in vitro and in vivo studies have investigated the pharmacological properties of UA reporting neuroprotective effects and improvements in cognitive function. These effects are attributed to its antioxidant, antiapoptotic, and anti-inflammatory actions.\u0000","PeriodicalId":10817,"journal":{"name":"Current Cosmetic Science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76541142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-25DOI: 10.2174/2666779702666230125142357
L. Kothapalli, V. Raut, Asha B. Thomas
Seed oils have been exploited for an array of purposes with their addition to dietary, cosmetics, or therapeutic products. The process of skin aging is a natural and complex phenomenon in living beings. Skin aging is classified into two independent processes, i.e., chronological aging and premature aging. Aging is observed as a loss of strength and elasticity of the skin, leading to wrinkles on the skin. It is due to a decrease in various components of the skin matrix, like elastin, collagen, and hyaluronic acid. Furthermore, aging is potentiated by excessive exposure to UV radiation (Photoaging) and can be prevented or reduced by using products that combat photoaging. Anti-aging and antiwrinkle agents are in demand for maintaining skin tone. Seed oils composed of polyunsaturated fatty acids are traditionally used in cosmetic products as moisturizers and emollients, while palmitic acid and oleic acid are known for their penetration-enhancing effect. With the changing trend for extraction of oils like cold pressed methods, seed oils enriched with polyphenols, flavonoids, carotenoids, and phytosterols are good antioxidants and antimicrobials and therefore have an ever-growing demand for their usage in the treatment of skin diseases. In this review, an attempt will be made to brief the phytoconstituents present in various seed oils and their utilization against skin ailments. Furthermore, a mechanistic approach towards the benefit of oils in skin barrier repair, antiaging, and photo-aging with the help of extensive well-designed clinical trials carried out in the recent past is elaborated. A literature search in the Scopus database, Pubmed, and Medline was carried out using the terminology “aging, photoaging, antioxidant, UV-protection, sunscreens, skin barrier repair, and fatty acids, formulations” in the study. Data were retrieved over the last twenty years. The review summarises the mechanistic approach and beneficial application of seed oils for healthy and glowing skin. The oils obtained from olives, sesame, borage, grape seeds, and carrot seeds have multitargeted effects. However, the variation in pharmacological effect may vary based on geographically differing varieties, skin type, and person-to-person variation. The need to standardize the varieties for their phytoactive ingredients and the composition of formulation used for skin care can help utilize the seeds as a potential source of actives against skin diseases. Conclusion: The potential of seed oils can be increased with appropriate analytical tools, validation protocols, and systematic experimental studies at preclinical and clinical trials for their application to skin care products.
{"title":"Seed Oils in Treatment of Skin Aging and Photoaging","authors":"L. Kothapalli, V. Raut, Asha B. Thomas","doi":"10.2174/2666779702666230125142357","DOIUrl":"https://doi.org/10.2174/2666779702666230125142357","url":null,"abstract":"\u0000\u0000Seed oils have been exploited for an array of purposes with their addition to dietary, cosmetics, or therapeutic products. The process of skin aging is a natural and complex phenomenon in living beings. Skin aging is classified into two independent processes, i.e., chronological aging and premature aging. Aging is observed as a loss of strength and elasticity of the skin, leading to wrinkles on the skin. It is due to a decrease in various components of the skin matrix, like elastin, collagen, and hyaluronic acid. Furthermore, aging is potentiated by excessive exposure to UV radiation (Photoaging) and can be prevented or reduced by using products that combat photoaging.\u0000\u0000\u0000\u0000Anti-aging and antiwrinkle agents are in demand for maintaining skin tone. Seed oils composed of polyunsaturated fatty acids are traditionally used in cosmetic products as moisturizers and emollients, while palmitic acid and oleic acid are known for their penetration-enhancing effect. With the changing trend for extraction of oils like cold pressed methods, seed oils enriched with polyphenols, flavonoids, carotenoids, and phytosterols are good antioxidants and antimicrobials and therefore have an ever-growing demand for their usage in the treatment of skin diseases. In this review, an attempt will be made to brief the phytoconstituents present in various seed oils and their utilization against skin ailments. Furthermore, a mechanistic approach towards the benefit of oils in skin barrier repair, antiaging, and photo-aging with the help of extensive well-designed clinical trials carried out in the recent past is elaborated.\u0000\u0000\u0000\u0000A literature search in the Scopus database, Pubmed, and Medline was carried out using the terminology “aging, photoaging, antioxidant, UV-protection, sunscreens, skin barrier repair, and fatty acids, formulations” in the study. Data were retrieved over the last twenty years.\u0000\u0000\u0000\u0000The review summarises the mechanistic approach and beneficial application of seed oils for healthy and glowing skin. The oils obtained from olives, sesame, borage, grape seeds, and carrot seeds have multitargeted effects. However, the variation in pharmacological effect may vary based on geographically differing varieties, skin type, and person-to-person variation. The need to standardize the varieties for their phytoactive ingredients and the composition of formulation used for skin care can help utilize the seeds as a potential source of actives against skin diseases.\u0000\u0000\u0000\u0000Conclusion: The potential of seed oils can be increased with appropriate analytical tools, validation protocols, and systematic experimental studies at preclinical and clinical trials for their application to skin care products.\u0000","PeriodicalId":10817,"journal":{"name":"Current Cosmetic Science","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79903182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-07DOI: 10.2174/2666779701666220907092152
V. Ansari, Aditya Singh, Tarique Mahmood, Farogh Ahsan, Rufaida Wasim
The structure, properties, synthesis, negligible toxicity, and surface modification of PAMAM (polyamidoamine dendrimers) are all discussed in this review. The properties of supramolecular PAMAM dendrimers in nanopolymer science have shown great progress in delivering medicines. A divergent strategy was used to construct a Generation four (G4.0) PAMAM dendrimer with an ethylenediaminetetraacetic acid core and repeating units of acrylic acid and ethylenediamine. PAMAM dendrimers, have an aminodoamine repeat branching architecture that starts with an ethylene diamine initiator core. A generation [G] is a set of branching steps that follow each other. Drug molecules can be transferred either as covalently bonded to the functional groups on the dendrimer surface or by forming non-covalent complexes with dendrimers. Full generation PAMAM dendrimers are terminated with amine surface [G0, G1, G2, G3, G4], whereas half-generation dendrimers are terminated with carboxylate [G1.5, G2.5, etc]. PAMAM dendrimers appear to have negligible toxicity and immunogenicity, as well as favorable biodistribution-: according to the current study they can improve drug solubility, prevent drug degradation, increase circulation time, and potentially target drugs. According to the characterization study, they exhibit strong lipophilic qualities, allowing them to easily pass the blood-brain barrier. Due to cheaper polydispersity index of dendrimers, they possess greater stability and the void spaces of dendrimers are accessible for drug loading. The existence of a duplet functional group on the dendrimers enables appending vectors, ligands and devices for targed the drug delivery in the body.
{"title":"Lipophilic PAMAM dendrimer: Conceptualization of targeted cosmetics and drug delivery","authors":"V. Ansari, Aditya Singh, Tarique Mahmood, Farogh Ahsan, Rufaida Wasim","doi":"10.2174/2666779701666220907092152","DOIUrl":"https://doi.org/10.2174/2666779701666220907092152","url":null,"abstract":"\u0000\u0000The structure, properties, synthesis, negligible toxicity, and surface modification of PAMAM (polyamidoamine dendrimers) are all discussed in this review. The properties of supramolecular PAMAM dendrimers in nanopolymer science have shown great progress in delivering medicines. A divergent strategy was used to construct a Generation four (G4.0) PAMAM dendrimer with an ethylenediaminetetraacetic acid core and repeating units of acrylic acid and ethylenediamine. PAMAM dendrimers, have an aminodoamine repeat branching architecture that starts with an ethylene diamine initiator core. A generation [G] is a set of branching steps that follow each other. Drug molecules can be transferred either as covalently bonded to the functional groups on the dendrimer surface or by forming non-covalent complexes with dendrimers. Full generation PAMAM dendrimers are terminated with amine surface [G0, G1, G2, G3, G4], whereas half-generation dendrimers are terminated with carboxylate [G1.5, G2.5, etc]. PAMAM dendrimers appear to have negligible toxicity and immunogenicity, as well as favorable biodistribution-: according to the current study they can improve drug solubility, prevent drug degradation, increase circulation time, and potentially target drugs. According to the characterization study, they exhibit strong lipophilic qualities, allowing them to easily pass the blood-brain barrier. Due to cheaper polydispersity index of dendrimers, they possess greater stability and the void spaces of dendrimers are accessible for drug loading. The existence of a duplet functional group on the dendrimers enables appending vectors, ligands and devices for targed the drug delivery in the body.\u0000","PeriodicalId":10817,"journal":{"name":"Current Cosmetic Science","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82419015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-19DOI: 10.2174/2666779701666220819144607
B. Sharma, Iti Chauhan
The majority of sunscreen cosmetics are emulsions or creams. However, formulations that use lipid nanoparticles as the delivery vehicle for sunscreen chemicals may offer benefits in terms of skin retention, enhancement of penetration through the epidermal layer, and Ultraviolet (UV) absorption and scattering. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) have been investigated to create sunscreen products with a low or medium UV protection factor. SLN and NLC have a wide range of characteristics and have been proven to effectively control the entry of actives showing UV protection activity through the skin. They have no hazardous effects; therefore, can be employed safely in dermatological and cosmetic preparations to obtain different traits. When utilized as vehicles for molecular sunscreens, lipid nanoparticles showed a synergistic impact of UV scattering. The ability to minimize the concentration of the molecular sunscreen, and hence its potential adverse effects, as well as the expenses of formulating pricey sunscreens, are all advantages derived from these studies. The review discusses some of the research where lipid nanoparticles have been used to encapsulate sunscreen agents. Exposure to sunlight is regarded as a key element in the aetiology of the gradual undesired changes in the skin look and physiology caused by UV rays present in the sunshine, hence evaluating sunscreen activity is an essential aspect of the cosmetic business. The author will also address some of the in vitro and in vivo assessments of sunscreens.
{"title":"In vitro and in vivo evaluation of sunscreen formulations containing nanolipid carriers","authors":"B. Sharma, Iti Chauhan","doi":"10.2174/2666779701666220819144607","DOIUrl":"https://doi.org/10.2174/2666779701666220819144607","url":null,"abstract":"\u0000\u0000The majority of sunscreen cosmetics are emulsions or creams. However, formulations that use lipid nanoparticles as the delivery vehicle for sunscreen chemicals may offer benefits in terms of skin retention, enhancement of penetration through the epidermal layer, and Ultraviolet (UV) absorption and scattering. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) have been investigated to create sunscreen products with a low or medium UV protection factor. SLN and NLC have a wide range of characteristics and have been proven to effectively control the entry of actives showing UV protection activity through the skin. They have no hazardous effects; therefore, can be employed safely in dermatological and cosmetic preparations to obtain different traits. When utilized as vehicles for molecular sunscreens, lipid nanoparticles showed a synergistic impact of UV scattering. The ability to minimize the concentration of the molecular sunscreen, and hence its potential adverse effects, as well as the expenses of formulating pricey sunscreens, are all advantages derived from these studies. The review discusses some of the research where lipid nanoparticles have been used to encapsulate sunscreen agents. Exposure to sunlight is regarded as a key element in the aetiology of the gradual undesired changes in the skin look and physiology caused by UV rays present in the sunshine, hence evaluating sunscreen activity is an essential aspect of the cosmetic business. The author will also address some of the in vitro and in vivo assessments of sunscreens.\u0000","PeriodicalId":10817,"journal":{"name":"Current Cosmetic Science","volume":"11 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90827111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-23DOI: 10.2174/2666779701666220623085521
Rishabh Gupta, Nimisha
Psoriasis is a chronic inflammatory disease with clinical manifestations of the skin that affect adults and children. It can have a significant negative impact on the physical, emotional, and, psychosocial wellbeing of affected patients. It has a strong genetic component but environmental factors such as infections can play an important role in the presentation of the disease. The patients suffering from a severe phase of this disease may have greater chances of occurrence of other diseases like cardiovascular disease, non-melanoma, and lymphoma. The present review majorly focuses on hallmarks of different types of psoriasis, evaluation of biomarkers to establish the severity and therapeutic response, and novel targeted therapies for the management of psoriasis. Potential herbal extracts and bioactive for the treatment of psoriasis are also highlighted here. A summary of pertinent, peer-reviewed English literature from databases like EBM, EMBASE, MEDLINE from 2010 to 2021 was used.
{"title":"Nanoformulations enabled possible solutions for the management of psoriasis.","authors":"Rishabh Gupta, Nimisha","doi":"10.2174/2666779701666220623085521","DOIUrl":"https://doi.org/10.2174/2666779701666220623085521","url":null,"abstract":"\u0000\u0000Psoriasis is a chronic inflammatory disease with clinical manifestations of the skin that affect adults and children. It can have a significant negative impact on the physical, emotional, and, psychosocial wellbeing of affected patients. It has a strong genetic component but environmental factors such as infections can play an important role in the presentation of the disease. The patients suffering from a severe phase of this disease may have greater chances of occurrence of other diseases like cardiovascular disease, non-melanoma, and lymphoma. The present review majorly focuses on hallmarks of different types of psoriasis, evaluation of biomarkers to establish the severity and therapeutic response, and novel targeted therapies for the management of psoriasis. Potential herbal extracts and bioactive for the treatment of psoriasis are also highlighted here. A summary of pertinent, peer-reviewed English literature from databases like EBM, EMBASE, MEDLINE from 2010 to 2021 was used.\u0000","PeriodicalId":10817,"journal":{"name":"Current Cosmetic Science","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79058038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-09DOI: 10.2174/2666779701666220509221341
Iti Chauhan, A. Singh, M. Yasir, Madhu Verma, Sagarika Majhi, Lubhan Singh
Glabridin (Glab) is a polyphenolic flavonoid of licorice acclaimed for its skin whitening properties. However its poor solubility, low physicochemical stability and inefficient percutaneous penetration create hurdles in the best use of this agent in dermocosmetic application. The purpose of the present work was to prepare and evaluate Glabridin loaded nanostructured lipid carrier (Glab NLC) in order to enhance its skin permeation and hence to promote its skin-whitening potential in cosmetic formulations. Nanostructured lipid carrier (NLC) has already proven its mettle in drug delivery via the skin by offering various benefits like high tolerability, biocompatibility, high drug loading, improved stability, close contact with stratum corneum leading to rich skin penetration and protection of bioactive from degradation. NLC was prepared by solvent emulsification diffusion technique and was evaluated for particle size, zeta potential, polydispersity index, drug loading and encapsulation, and in vitro drug release. Optimized formulation was incorporated into a cream base and skin whitening activity was evaluated. Glycerol monostearate (GMS) and olive oil were chosen as solid and liquid lipids for NLC formulation. The particle size, PDI, zeta potential, entrapment efficiency, and drug release of optimized formulation were found to be 189 nm, 0.259, -14.5mV, 94.56 %, and 98.86 ± 0.80 % respectively. The optimized NLC was incorporated into a suitable cream base and evaluated. The skin whitening activity of Glabridin NLC cream was determined by performing tyrosinase inhibition activity. The percentage inhibition value of GlabNLC loaded cream and Kojic acid against mushroom tyrosinase was found to be 60.31% and 52.61% respectively. The obtained results advocate for lipid particles as an appropriate carrier of Glabridin for skin whitening cosmetic cream.
{"title":"Development and characterization of nano-structure lipid carrier-based Glabridin cream for cosmetic use","authors":"Iti Chauhan, A. Singh, M. Yasir, Madhu Verma, Sagarika Majhi, Lubhan Singh","doi":"10.2174/2666779701666220509221341","DOIUrl":"https://doi.org/10.2174/2666779701666220509221341","url":null,"abstract":"\u0000\u0000Glabridin (Glab) is a polyphenolic flavonoid of licorice acclaimed for its skin whitening properties. However its poor solubility, low physicochemical stability and inefficient percutaneous penetration create hurdles in the best use of this agent in dermocosmetic application. The purpose of the present work was to prepare and evaluate Glabridin loaded nanostructured lipid carrier (Glab NLC) in order to enhance its skin permeation and hence to promote its skin-whitening potential in cosmetic formulations. Nanostructured lipid carrier (NLC) has already proven its mettle in drug delivery via the skin by offering various benefits like high tolerability, biocompatibility, high drug loading, improved stability, close contact with stratum corneum leading to rich skin penetration and protection of bioactive from degradation.\u0000\u0000\u0000\u0000NLC was prepared by solvent emulsification diffusion technique and was evaluated for particle size, zeta potential, polydispersity index, drug loading and encapsulation, and in vitro drug release. Optimized formulation was incorporated into a cream base and skin whitening activity was evaluated. Glycerol monostearate (GMS) and olive oil were chosen as solid and liquid lipids for NLC formulation.\u0000\u0000\u0000\u0000The particle size, PDI, zeta potential, entrapment efficiency, and drug release of optimized formulation were found to be 189 nm, 0.259, -14.5mV, 94.56 %, and 98.86 ± 0.80 % respectively. The optimized NLC was incorporated into a suitable cream base and evaluated. The skin whitening activity of Glabridin NLC cream was determined by performing tyrosinase inhibition activity. The percentage inhibition value of GlabNLC loaded cream and Kojic acid against mushroom tyrosinase was found to be 60.31% and 52.61% respectively.\u0000\u0000\u0000\u0000The obtained results advocate for lipid particles as an appropriate carrier of Glabridin for skin whitening cosmetic cream.\u0000","PeriodicalId":10817,"journal":{"name":"Current Cosmetic Science","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78633019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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