Pub Date : 2023-10-20DOI: 10.2174/0126667797256475231004105550
Gabriela Amanda Brignoli da Silva, Mariane Massufero Vergilio, Silas Arandas Monteiro e Silva, Catarina Rosado, Ediléia Bagatin, Gislaine Leonardi
Background:: In several countries, still there is no standardized regulation on the use of claims. However, there are some guideline materials and content that are used by regulatory agencies. Objective:: The goal of this manuscript is to provide an approach to the understanding of the thematic of cosmetic claims to dermatologists and general practice physicians. The objective is to discuss the definition, regulatory framework and tips to help them on how to use this knowledge to guarantee an assertive indication. Results:: Knowing the appropriate tests for the substantiation of claims allows the physician to indicate the most appropriate dermocosmetic for the skin condition of each patient. Conclusion:: For a more critical and assertive indication or suggestion, it is recommended that the physician observe the product packaging and know how to understand and interpret the terms on the product label.
{"title":"A critical overview about cosmetic labeling claims","authors":"Gabriela Amanda Brignoli da Silva, Mariane Massufero Vergilio, Silas Arandas Monteiro e Silva, Catarina Rosado, Ediléia Bagatin, Gislaine Leonardi","doi":"10.2174/0126667797256475231004105550","DOIUrl":"https://doi.org/10.2174/0126667797256475231004105550","url":null,"abstract":"Background:: In several countries, still there is no standardized regulation on the use of claims. However, there are some guideline materials and content that are used by regulatory agencies. Objective:: The goal of this manuscript is to provide an approach to the understanding of the thematic of cosmetic claims to dermatologists and general practice physicians. The objective is to discuss the definition, regulatory framework and tips to help them on how to use this knowledge to guarantee an assertive indication. Results:: Knowing the appropriate tests for the substantiation of claims allows the physician to indicate the most appropriate dermocosmetic for the skin condition of each patient. Conclusion:: For a more critical and assertive indication or suggestion, it is recommended that the physician observe the product packaging and know how to understand and interpret the terms on the product label.","PeriodicalId":10817,"journal":{"name":"Current Cosmetic Science","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135616861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-10DOI: 10.2174/2666779702666230918094033
Shubhrat Maheshwari, Aditya Singh
Background: Recently, transferosomes have been discovered to have the potential for transdermal delivery. Curcumin is a bioactive molecule with anti-inflammatory and antioxidant properties, but it has low water solubility and poor skin absorption. The biological response to damage caused by diverse stimuli is known as the inflammatory process. Cyclodextrins are cyclic (-1, 4)-linked oligosaccharides of -D-glucopyranose with a hydrophilic outer surface and a hydrophobic center cavity. Aim: The aim of the study was to develop a curcumin-loaded transferosomal gel to improve the wound healing process. The study has focused on advancing the area of traditional medicine in the field of pharmaceutics by using curcumin in the form of transferosomes to enhance wound healing. Method: Firstly, curcumin was used to synthesize the transferosomes. Secondly, the transferosomes were converted into a transferosomal gel as an alternative for wound healing. Characterization and in vivo investigation were carried out on female Swiss mice. Results: Unpaired Student’s t-test was used to determine the statistical significance at p < 0.5 using UV exposure schedules. All values have been expressed as mean ± SEM calculated by ANOVA with a significant difference among means at P < 0.05. Conclusion: The study has indicated curcumin to be successfully entrapped in transferosomes in order to formulate the gel with powerful wound healing properties.
背景:最近，转移体被发现具有透皮传递的潜力。姜黄素是一种具有抗炎和抗氧化特性的生物活性分子，但它的水溶性低，皮肤吸收性差。对各种刺激引起的损伤的生物反应被称为炎症过程。环糊精是- d -葡萄糖醛酸的环(- 1,4)连接低聚糖，具有亲水的外表面和疏水的中心空腔。目的:研究的目的是开发一个curcumin-loaded transferosomal凝胶改善伤口愈合过程。研究的重点是利用姜黄素以转移体的形式促进伤口愈合，从而推动传统医学在药剂学领域的发展。方法:首先用姜黄素合成转移体。其次，将转移体转化为转移体凝胶，作为伤口愈合的替代品。对雌性瑞士小鼠进行了表征和体内研究。结果:采用Unpaired Student’s t检验检验p <0.5使用紫外线曝光表。所有数值均以方差分析计算的均数±SEM表示，均数之间有显著差异，P <0.05. 结论:姜黄素可以成功地包埋在转移体中，从而制备出具有较强伤口愈合性能的凝胶。
{"title":"Development and Evaluation of Curcumin-based Transferosomal Gel for Wound Healing","authors":"Shubhrat Maheshwari, Aditya Singh","doi":"10.2174/2666779702666230918094033","DOIUrl":"https://doi.org/10.2174/2666779702666230918094033","url":null,"abstract":"Background: Recently, transferosomes have been discovered to have the potential for transdermal delivery. Curcumin is a bioactive molecule with anti-inflammatory and antioxidant properties, but it has low water solubility and poor skin absorption. The biological response to damage caused by diverse stimuli is known as the inflammatory process. Cyclodextrins are cyclic (-1, 4)-linked oligosaccharides of -D-glucopyranose with a hydrophilic outer surface and a hydrophobic center cavity. Aim: The aim of the study was to develop a curcumin-loaded transferosomal gel to improve the wound healing process. The study has focused on advancing the area of traditional medicine in the field of pharmaceutics by using curcumin in the form of transferosomes to enhance wound healing. Method: Firstly, curcumin was used to synthesize the transferosomes. Secondly, the transferosomes were converted into a transferosomal gel as an alternative for wound healing. Characterization and in vivo investigation were carried out on female Swiss mice. Results: Unpaired Student’s t-test was used to determine the statistical significance at p < 0.5 using UV exposure schedules. All values have been expressed as mean ± SEM calculated by ANOVA with a significant difference among means at P < 0.05. Conclusion: The study has indicated curcumin to be successfully entrapped in transferosomes in order to formulate the gel with powerful wound healing properties.","PeriodicalId":10817,"journal":{"name":"Current Cosmetic Science","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136254655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-28DOI: 10.2174/2666779702666230828094003
R. Rastogi, Galwin D Lima, Anjali Gholap
Multiple moisturizing solutions with sodium hyaluronate, Withania sominifera, and niacinamide are commercially popular. Detailed clinical studies portraying their activity are not available. This study aims to study the clinical efficacy of a phyto-bioactive cream in improving skin hydration and tone with 4 weeks of continuous usage. We conducted a non-comparative, single-blind study on 50 Asian female volunteers with Fitzpatrick skin types III and IV for 28 days. Cosmetic acceptability and safety of the product were established via self-evaluation questionnaires. The ability of the topical formulation in maintaining skin tone, hydration, and firmness was determined by instrumental analysis and smoothness by dermatologist evaluation. A total of 46 subjects completed the study. High levels of skin hydration were noted instantaneously (+61.11%) and post continuous use of the product. Significant reduction in the appearance of age/dark spots (ITA°), Δ ITA°= 37.49% and increase in skin lightness (L) by 2.66% compared to baseline was observed in 4 weeks. More than 80% of the subjects reported an increase in skin firmness and smoothness in 4 weeks of twice-a-day product usage. Our study establishes the safety and acceptability of the phyto-bioactive cream. The efficiency of the combination of Withania somnifera extract, sodium hyaluronate, and niacinamide in improving skin hydration and tone has been proven.
{"title":"Combination of sodium hyaluronate, Withania somnifera extract and niacinamide improves hydration and skin tone – A clinical study","authors":"R. Rastogi, Galwin D Lima, Anjali Gholap","doi":"10.2174/2666779702666230828094003","DOIUrl":"https://doi.org/10.2174/2666779702666230828094003","url":null,"abstract":"\u0000\u0000Multiple moisturizing solutions with sodium hyaluronate, Withania sominifera, and niacinamide are commercially popular. Detailed clinical studies portraying their activity are not available.\u0000\u0000\u0000\u0000This study aims to study the clinical efficacy of a phyto-bioactive cream in improving skin hydration and tone with 4 weeks of continuous usage.\u0000\u0000\u0000\u0000We conducted a non-comparative, single-blind study on 50 Asian female volunteers with Fitzpatrick skin types III and IV for 28 days. Cosmetic acceptability and safety of the product were established via self-evaluation questionnaires. The ability of the topical formulation in maintaining skin tone, hydration, and firmness was determined by instrumental analysis and smoothness by dermatologist evaluation.\u0000\u0000\u0000\u0000A total of 46 subjects completed the study. High levels of skin hydration were noted instantaneously (+61.11%) and post continuous use of the product. Significant reduction in the appearance of age/dark spots (ITA°), Δ ITA°= 37.49% and increase in skin lightness (L) by 2.66% compared to baseline was observed in 4 weeks. More than 80% of the subjects reported an increase in skin firmness and smoothness in 4 weeks of twice-a-day product usage.\u0000\u0000\u0000\u0000Our study establishes the safety and acceptability of the phyto-bioactive cream. The efficiency of the combination of Withania somnifera extract, sodium hyaluronate, and niacinamide in improving skin hydration and tone has been proven.\u0000","PeriodicalId":10817,"journal":{"name":"Current Cosmetic Science","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91413209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-31DOI: 10.2174/2666779702666230731161153
Ehsan Eslahi, N. Hashemi
The aim of this study was to evaluate the brightening effects of a complex composed of Resorcinol, Arbutin, and Licorice root extract (RAL complex) in patients faced with skin spots compared to a potential hydroquinone compound. Skin spots are defined as excessive accumulation of melanin pigment in different layers of the skin caused by extravagant sun exposure, pregnancy, and other hormonal and genetic factors. Therefore, it is necessary to use appropriate products to treat these types of spots. To evaluate skin brightness after using the RAL complex, this study was designed in a double-blind randomized trial and the removal of melanin pigment and skin spots was evaluated by different methods. In this study, the brightening cream formulated with actives comprising the RAL complex in 2.1% w/w concentration and a hydroquinone cream was applied in two groups of 20 women with a mean age of 48 years showing the severity scale 3 of skin pigmentation, separately. This study was conducted to evaluate the brightening effect of this complex compared to a hydroquinone compound after 4, 8, and, 12 weeks of application to the entire face. The results showed the highest percentage of skin brightness 12 weeks after applying the cream, reported at 93% and 89% for RAL complex and hydroquinone compound, respectively. Skin pigmentation rate was measured before and after applying the RAL complex cream with a mexameter device. The highest amount of dark spot removal was seen after using this cream in different areas of the skin. The results showed that the RAL complex was more effective than the hydroquinone compound in removing skin blemishes without any side effects compared to products containing hydroquinone.
{"title":"Anti-spot Effects of Developed Brightening Cream Composed of Three Active Ingredients (Resorcinol, Arbutin, and Licorice root extract) in Comparison with the Hydroquinone Cream)","authors":"Ehsan Eslahi, N. Hashemi","doi":"10.2174/2666779702666230731161153","DOIUrl":"https://doi.org/10.2174/2666779702666230731161153","url":null,"abstract":"\u0000\u0000The aim of this study was to evaluate the brightening effects of a complex composed of Resorcinol, Arbutin, and Licorice root extract (RAL complex) in patients faced with skin spots compared to a potential hydroquinone compound.\u0000\u0000\u0000\u0000Skin spots are defined as excessive accumulation of melanin pigment in different layers of the skin caused by extravagant sun exposure, pregnancy, and other hormonal and genetic factors. Therefore, it is necessary to use appropriate products to treat these types of spots.\u0000\u0000\u0000\u0000To evaluate skin brightness after using the RAL complex, this study was designed in a double-blind randomized trial and the removal of melanin pigment and skin spots was evaluated by different methods.\u0000\u0000\u0000\u0000In this study, the brightening cream formulated with actives comprising the RAL complex in 2.1% w/w concentration and a hydroquinone cream was applied in two groups of 20 women with a mean age of 48 years showing the severity scale 3 of skin pigmentation, separately. This study was conducted to evaluate the brightening effect of this complex compared to a hydroquinone compound after 4, 8, and, 12 weeks of application to the entire face.\u0000\u0000\u0000\u0000The results showed the highest percentage of skin brightness 12 weeks after applying the cream, reported at 93% and 89% for RAL complex and hydroquinone compound, respectively. Skin pigmentation rate was measured before and after applying the RAL complex cream with a mexameter device. The highest amount of dark spot removal was seen after using this cream in different areas of the skin.\u0000\u0000\u0000\u0000The results showed that the RAL complex was more effective than the hydroquinone compound in removing skin blemishes without any side effects compared to products containing hydroquinone.\u0000","PeriodicalId":10817,"journal":{"name":"Current Cosmetic Science","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83364614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-27DOI: 10.2174/2666779702666230727124252
J. Akhtar, Asad Ahmad, Mohammad Ahmad, M. Irfan, Badruddeen, Aditya Singh
The process of wound healing is a complicated series of organized biochemical and cellular phenomena that restore the integrity of the skin and subcutaneous tissue. A drug molecule can be transported to the site of action through a variety of carriers, including niosomes or non-ionic surfactant vesicles. They can trap medications that are both hydrophilic and hydrophobic. It has been demonstrated that curcumin has strong analgesic, anti-inflammatory, and wound-healing qualities. In the current study, an effort has been made to create a curcumin-loaded niosomal gel for efficient wound healing therapy. Utilizing non-ionic surfactants (Span 60, Span 20, Tween 20, and Tween 60) and cholesterol at various concentrations, a modified thin-film hydration process was used to create niosomal gels containing curcumin. Particle size, shape, entrapment effectiveness, deformability, and in vitro skin penetration were used to describe the vesicles. The 1% carbopol 940 gel was then made using the improved formulation. In wound-induced rats, the effectiveness of the in vivo wound healing was assessed. The manufactured niosomes were discovered to be homogeneous in size and spherical in shape. According to the IR spectrum study, the medication and formulation additives did not interact. It was discovered that the niosomal gel (S-3) loaded with curcumin was not irritating to the skin. According to studies on in vivo wound healing, curcumin-loaded niosomal gel exhibited the highest percentage of wound contraction. Following 21 days of niosomal gel treatment, the histopathological evaluation found a noticeable improvement in the skin's histological architecture. Curcumin-loaded niosomal gel was easily made using the thin film hydration process. The results of this study demonstrate the potential of niosomal gel as a cutting-edge therapeutic strategy for wound healing.
伤口愈合的过程是一系列复杂的有组织的生化和细胞现象，恢复皮肤和皮下组织的完整性。药物分子可以通过多种载体(包括乳质体或非离子表面活性剂囊泡)运输到作用部位。它们可以捕获既亲水又疏水的药物。已经证明姜黄素具有很强的镇痛、抗炎和伤口愈合的特性。在目前的研究中，已经努力创造一种姜黄素负载的niosomal凝胶用于有效的伤口愈合治疗。利用不同浓度的非离子表面活性剂(Span 60、Span 20、Tween 20和Tween 60)和胆固醇，采用改进的薄膜水合工艺制备含有姜黄素的乳质体凝胶。用颗粒大小、形状、包裹有效性、可变形性和体外皮肤穿透性来描述囊泡。用改进后的配方制备1%卡波波尔940凝胶。对创面诱导大鼠进行体内创面愈合效果评价。所制备的颗粒体大小均匀，形状呈球形。根据红外光谱研究，药物和制剂添加剂没有相互作用。研究发现，载姜黄素的niosomal gel (S-3)对皮肤无刺激性。根据体内伤口愈合的研究，姜黄素负载的niosomal gel具有最高的伤口收缩率。在21天的乳质体凝胶治疗后，组织病理学评估发现皮肤的组织学结构有明显的改善。采用薄膜水合法制备了载姜黄素的乳质体凝胶。这项研究的结果证明了niosomal gel作为一种尖端的伤口愈合治疗策略的潜力。
{"title":"Development and Evaluation of Curcumin-loaded Niosomal Gel for Wound Healing in Rats","authors":"J. Akhtar, Asad Ahmad, Mohammad Ahmad, M. Irfan, Badruddeen, Aditya Singh","doi":"10.2174/2666779702666230727124252","DOIUrl":"https://doi.org/10.2174/2666779702666230727124252","url":null,"abstract":"\u0000\u0000The process of wound healing is a complicated series of organized biochemical and cellular phenomena that restore the integrity of the skin and subcutaneous tissue. A drug molecule can be transported to the site of action through a variety of carriers, including niosomes or non-ionic surfactant vesicles. They can trap medications that are both hydrophilic and hydrophobic. It has been demonstrated that curcumin has strong analgesic, anti-inflammatory, and wound-healing qualities.\u0000\u0000\u0000\u0000In the current study, an effort has been made to create a curcumin-loaded niosomal gel for efficient wound healing therapy. Utilizing non-ionic surfactants (Span 60, Span 20, Tween 20, and Tween 60) and cholesterol at various concentrations, a modified thin-film hydration process was used to create niosomal gels containing curcumin. Particle size, shape, entrapment effectiveness, deformability, and in vitro skin penetration were used to describe the vesicles. The 1% carbopol 940 gel was then made using the improved formulation. In wound-induced rats, the effectiveness of the in vivo wound healing was assessed.\u0000\u0000\u0000\u0000The manufactured niosomes were discovered to be homogeneous in size and spherical in shape. According to the IR spectrum study, the medication and formulation additives did not interact. It was discovered that the niosomal gel (S-3) loaded with curcumin was not irritating to the skin. According to studies on in vivo wound healing, curcumin-loaded niosomal gel exhibited the highest percentage of wound contraction. Following 21 days of niosomal gel treatment, the histopathological evaluation found a noticeable improvement in the skin's histological architecture. Curcumin-loaded niosomal gel was easily made using the thin film hydration process.\u0000\u0000\u0000\u0000The results of this study demonstrate the potential of niosomal gel as a cutting-edge therapeutic strategy for wound healing.\u0000","PeriodicalId":10817,"journal":{"name":"Current Cosmetic Science","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83664900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-18DOI: 10.2174/2666779702666230418104430
Sesto Cabral Maria Eugenia, González Elías Exequiel, Moreno Maria Julieta
The movement of conscious consumption is growing rapidly. The idea of leaving behind synthetic products and substances that generate waste from their production to their final disposal grows and widens the gap between the old capitalist paradigm and the concept of naturism. It includes environmental awareness, taking care of our body, and the conscious choice of what we eat, wear, and use in daily life, including cosmetic products. This study aimed to explore a new paradigm of formulation and consumption. A group of parabens was selected, and their replacement with preservatives approved for natural cosmetics was proposed. Some of the risks associated with the consumption of parabens in food, cosmetics, and medicines, were also examined. Moreover, the advantages and disadvantages of preservatives for the product and consumer were also discussed. For data collection, publications in indexed journals were searched, with the keywords: parabens, endocrine disrupting chemicals, and skin conditions related to the use of parabens. Recent studies have reported that by using parabens in skin products, we create an imbalance in the skin flora. This preservative decreases the defense capacity of our first immune line and causes disorders that lead to irritation, rosacea spots, oiliness, and sectorized peeling. Furthermore, parabens are exogenous substances that alter the functions of the endocrine system and can cause adverse health effects. In Argentina, compounds from the paraben family are used by many brands as preservatives, which are dangerous to health and the environment. Therefore, a conscious, sustainable, biodegradable, and cruelty-free alternative is needed to replace parabens in cosmetics
{"title":"Rethinking for Natural Pharmaceutical Technology: Parabens as Cosmetic Preservatives and their Potential as Chemical Endocrine Disruptors","authors":"Sesto Cabral Maria Eugenia, González Elías Exequiel, Moreno Maria Julieta","doi":"10.2174/2666779702666230418104430","DOIUrl":"https://doi.org/10.2174/2666779702666230418104430","url":null,"abstract":"\u0000\u0000The movement of conscious consumption is growing rapidly. The idea of leaving behind synthetic products and substances that generate waste from their production to their final disposal grows and widens the gap between the old capitalist paradigm and the concept of naturism. It includes environmental awareness, taking care of our body, and the conscious choice of what we eat, wear, and use in daily life, including cosmetic products.\u0000\u0000\u0000\u0000This study aimed to explore a new paradigm of formulation and consumption. A group of parabens was selected, and their replacement with preservatives approved for natural cosmetics was proposed. Some of the risks associated with the consumption of parabens in food, cosmetics, and medicines, were also examined. Moreover, the advantages and disadvantages of preservatives for the product and consumer were also discussed.\u0000\u0000\u0000\u0000For data collection, publications in indexed journals were searched, with the keywords: parabens, endocrine disrupting chemicals, and skin conditions related to the use of parabens.\u0000\u0000\u0000\u0000Recent studies have reported that by using parabens in skin products, we create an imbalance in the skin flora. This preservative decreases the defense capacity of our first immune line and causes disorders that lead to irritation, rosacea spots, oiliness, and sectorized peeling. Furthermore, parabens are exogenous substances that alter the functions of the endocrine system and can cause adverse health effects.\u0000\u0000\u0000\u0000In Argentina, compounds from the paraben family are used by many brands as preservatives, which are dangerous to health and the environment. Therefore, a conscious, sustainable, biodegradable, and cruelty-free alternative is needed to replace parabens in cosmetics\u0000","PeriodicalId":10817,"journal":{"name":"Current Cosmetic Science","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84440669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-13DOI: 10.2174/2666779702666230413090319
Neelottama Kushwaha, Swatantra K.S. Kushwaha
The confluence of three key fields, namely, cosmetics, pharmaceutics, and the chemistry of cosmetic items with the human body system, is known as cosmeceutical chemistry. The most remarkable logical knowledge and innovation are incorporated into cosmetology, including science, pharmacology, subatomic physics and nervous system science, etc. Cosmetics are items created to beautify, protect, and change the appearance of our bodies' external features. Water, emulsifiers, preservatives, thickeners, moisturizing agents, colors, and perfumes are the main components found in the majority of cosmetics. Ingredients may be synthetic or naturally occurring, but how they may affect our health mostly depends on the chemical substances they are made of. The concentrations of potentially harmful compounds present in cosmetics are thought to be too low to endanger human health. Nowadays, various types of cosmetics are available in the market such as lotions, lipstick, colognes, nail paints, and other products. After using the base cream, various cosmetics, such as face powder, provide skin luster. To achieve detergency, wetting, emulsifying, re-coloring, and moderating effects, cosmetic fixings/excipients are used. Some unfriendly synthetic reactions in the preparation of cosmetics cause serious dangerous effects on people and the environment. The usage of several cosmetics has restorative effects. Once more, each population has a specific makeup of cosmetic users. The distinction between cosmetic and medical research is becoming increasingly blurred as a result of this growing application of science to beauty. Leading cosmetic companies' laboratories conduct cutting-edge research in areas like grid science, cell reinforcements, and mature forms. Their manufacturing, marketing, and delivery should all be subject to proper rules and regulations in addition to pricing.
{"title":"A comprehensive review of cosmeceutical chemistry","authors":"Neelottama Kushwaha, Swatantra K.S. Kushwaha","doi":"10.2174/2666779702666230413090319","DOIUrl":"https://doi.org/10.2174/2666779702666230413090319","url":null,"abstract":"\u0000\u0000The confluence of three key fields, namely, cosmetics, pharmaceutics, and the chemistry of cosmetic items with the human body system, is known as cosmeceutical chemistry. The most remarkable logical knowledge and innovation are incorporated into cosmetology, including science, pharmacology, subatomic physics and nervous system science, etc. Cosmetics are items created to beautify, protect, and change the appearance of our bodies' external features. Water, emulsifiers, preservatives, thickeners, moisturizing agents, colors, and perfumes are the main components found in the majority of cosmetics. Ingredients may be synthetic or naturally occurring, but how they may affect our health mostly depends on the chemical substances they are made of. The concentrations of potentially harmful compounds present in cosmetics are thought to be too low to endanger human health. Nowadays, various types of cosmetics are available in the market such as lotions, lipstick, colognes, nail paints, and other products. After using the base cream, various cosmetics, such as face powder, provide skin luster. To achieve detergency, wetting, emulsifying, re-coloring, and moderating effects, cosmetic fixings/excipients are used. Some unfriendly synthetic reactions in the preparation of cosmetics cause serious dangerous effects on people and the environment. The usage of several cosmetics has restorative effects. Once more, each population has a specific makeup of cosmetic users. The distinction between cosmetic and medical research is becoming increasingly blurred as a result of this growing application of science to beauty. Leading cosmetic companies' laboratories conduct cutting-edge research in areas like grid science, cell reinforcements, and mature forms. Their manufacturing, marketing, and delivery should all be subject to proper rules and regulations in addition to pricing.\u0000","PeriodicalId":10817,"journal":{"name":"Current Cosmetic Science","volume":"186 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86937042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-12DOI: 10.2174/2666779702666230412140202
U. Shinde, Gauri V. Khanvalkar
This work aimed to determine whether the oxybenzone-loaded nanocapsule gel (NC gel) can reduce the degree of skin penetration and, thereby, the skin irritation caused by the drug. Sunscreens must be retained on the uppermost skin surface, forming a protective film throughout the entire UV exposure period. Skin penetration and/or light-induced decomposition of sunscreens is undesirable as this would decrease the expected UV protection. The changes in colour and appearance of the sunscreen, as well as the possible increase in the phototoxicity and allergenic potential of sunscreen breakdown products, are also of concern. Furthermore, exposure to UVB radiation leads to impairment in the stratum corneum and hence enhances the skin's penetration of sunscreen actives, leading to systemic absorption. Currently, available sunscreen agents are low-molecular-weight lipophilic molecules, which make them capable of penetrating the skin and being systemically absorbed. Oxybenzone is an organic compound widely used in commercial sunscreen preparations. The low molecular weight and lipophilic nature of oxybenzone facilitate penetration through the stratum corneum, leading to irritation and allergic reactions. Polymeric nanocapsules (NCs) have been developed to ensure a controlled release of pharmaceutical and cosmetic agents and/or exert a preventive effect against the harmful side effects induced by direct contact of tissues with high amounts of the drug. Hence, we hypothesised that encapsulating the oxybenzone polymeric nanocapsule system would reduce the irritation and its allergic potential upon topical application. The objective of the current study was to develop polymeric nanocapsule based gel of oxybenzone and investigate the skin deposition by ex vivo permeation studies. The current study aimed to develop a polymeric nanocapsule-based gel of oxybenzone and investigate its skin deposition by ex vivo permeation studies. The polymeric nanocapsules were prepared by the solvent displacement method using a combination of Eudragit RSPO and Eudragit RLPO polymers. Further nanocapsules were incorporated into the xanthan gum gel base. It was evaluated for particle size, PDI, zeta potential, drug content, in vitro release, ex vivo permeation, sunscreen efficacy and skin irritation potential by the HET CAM test. Particle size, PDI, zeta potential, percent encapsulation and loading of drug-loaded nanocapsule suspension were found to be 237.1nm, 0.189 +58.4 mV, 85±2.51% and 19.45%±0.94%. DSC results indicate the suitability of selected excipients. In vitro release studies indicated 68.99% oxybenzone release from NC suspension while NC gel showed a 58.87% at the end of 24 hrs. Ex vivo permeation results showed significantly higher drug permeation from plain oxybenzone gel compared to NC gel. Permeation flux and enhancement ratio suggest a three times reduction in skin permeation by NC gel. The gel offered medium-level sun protection with an SPF value
{"title":"Oxybenzone-loaded Polymeric Nanocapsule Gel: Strategy to Reduce Drug-induced Skin Penetration and Irritation","authors":"U. Shinde, Gauri V. Khanvalkar","doi":"10.2174/2666779702666230412140202","DOIUrl":"https://doi.org/10.2174/2666779702666230412140202","url":null,"abstract":"\u0000\u0000This work aimed to determine whether the oxybenzone-loaded nanocapsule gel (NC gel) can reduce the degree of skin penetration and, thereby, the skin irritation caused by the drug.\u0000\u0000\u0000\u0000Sunscreens must be retained on the uppermost skin surface, forming a protective film throughout the entire UV exposure period. Skin penetration and/or light-induced decomposition of sunscreens is undesirable as this would decrease the expected UV protection. The changes in colour and appearance of the sunscreen, as well as the possible increase in the phototoxicity and allergenic potential of sunscreen breakdown products, are also of concern.\u0000Furthermore, exposure to UVB radiation leads to impairment in the stratum corneum and hence enhances the skin's penetration of sunscreen actives, leading to systemic absorption. Currently, available sunscreen agents are low-molecular-weight lipophilic molecules, which make them capable of penetrating the skin and being systemically absorbed.\u0000Oxybenzone is an organic compound widely used in commercial sunscreen preparations. The low molecular weight and lipophilic nature of oxybenzone facilitate penetration through the stratum corneum, leading to irritation and allergic reactions.\u0000Polymeric nanocapsules (NCs) have been developed to ensure a controlled release of pharmaceutical and cosmetic agents and/or exert a preventive effect against the harmful side effects induced by direct contact of tissues with high amounts of the drug. Hence, we hypothesised that encapsulating the oxybenzone polymeric nanocapsule system would reduce the irritation and its allergic potential upon topical application.\u0000\u0000\u0000\u0000The objective of the current study was to develop polymeric nanocapsule based gel of oxybenzone and investigate the skin deposition by ex vivo permeation studies.\u0000\u0000\u0000\u0000The current study aimed to develop a polymeric nanocapsule-based gel of oxybenzone and investigate its skin deposition by ex vivo permeation studies.\u0000\u0000\u0000\u0000The polymeric nanocapsules were prepared by the solvent displacement method using a combination of Eudragit RSPO and Eudragit RLPO polymers. Further nanocapsules were incorporated into the xanthan gum gel base. It was evaluated for particle size, PDI, zeta potential, drug content, in vitro release, ex vivo permeation, sunscreen efficacy and skin irritation potential by the HET CAM test.\u0000\u0000\u0000\u0000Particle size, PDI, zeta potential, percent encapsulation and loading of drug-loaded nanocapsule suspension were found to be 237.1nm, 0.189 +58.4 mV, 85±2.51% and 19.45%±0.94%. DSC results indicate the suitability of selected excipients. In vitro release studies indicated 68.99% oxybenzone release from NC suspension while NC gel showed a 58.87% at the end of 24 hrs. Ex vivo permeation results showed significantly higher drug permeation from plain oxybenzone gel compared to NC gel. Permeation flux and enhancement ratio suggest a three times reduction in skin permeation by NC gel. The gel offered medium-level sun protection with an SPF value","PeriodicalId":10817,"journal":{"name":"Current Cosmetic Science","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78689913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-03DOI: 10.2174/2666779702666230403111920
Chhaya Harihar Gadgoli, Mansi Kolambe, A. Naik
Orange coloured tubular calyx of Nyctanthes arbor-tristis can be utilized as a substitute for saffron due to the presence of crocin, an apocarotenoid, which can act as a sunscreen agent. Petroselinic acid is reported to have a moisturizing effect on the skin. To utilize the tubular calyx of Nyctanthes arbor- tristis as an economical source of crocin and Coriandrum sativum seed oil as a source of petroselinic acid for the development of a stable phytosomal gel formulation and to evaluate its sunscreen and moisturizing activities. To utilize tubular calyx of Nyctanthes arbor- tristis as an economical source of crocin and Coriandrum sativum seed oil as source of petroselinic acid, for development of a stable phytosomal gel formulation and to evaluate its sunscreen and moisturizing activities. Phytosomes of standardized crocin-rich extract and petroselinic acid were prepared separately by lipid film hydration technique. The phytosomes were then incorporated into a gel base prepared from dehydroxanthan gum, and it was evaluated for in-vitro sunscreen activity by using Mansur’s equation. Moisturizing effect of the phytosomal gel was evaluated on 10 healthy female volunteers with their informed consent, and the water content of the stratum corneum was measured by using a Digital Moisture detector pen before and 5 hours later the application of the gel. Mean initial moisture content of the skin was found to be 30.08 %, which was significantly (P< 0.05) raised to 45.59% at the end of 5 hours. Sun Protection Factor was found to be 15.09 and with a Boot Star rating of 2. Mean initial moisture content of skin was found to be 30.08 %, which was significantly (P< 0.05) raised to 45.59% at the end of 5 hours. Sun Protection Factor was found to be 15.09 and with Boot Star rating of 2. Entrapping the phytoconstituents in vesicles increased stability, and the formulation was found to have moderate protection and a good moisturizing effect on the skin. Entrapping the phytoconstituents in vesicles increased stability and the formulation was found to have moderate protection and good moisturizing effect on skin.
{"title":"Formulation Containing Phytosomes of Crocin-Rich Extract from Nyctanthes arbor-tristis and Petroselinic Acid from Coriandrum sativum seeds Exhibits Sunscreen and Moisturizing Effects","authors":"Chhaya Harihar Gadgoli, Mansi Kolambe, A. Naik","doi":"10.2174/2666779702666230403111920","DOIUrl":"https://doi.org/10.2174/2666779702666230403111920","url":null,"abstract":"\u0000\u0000Orange coloured tubular calyx of Nyctanthes arbor-tristis can be utilized as a substitute for saffron due to the presence of crocin, an apocarotenoid, which can act as a sunscreen agent. Petroselinic acid is reported to have a moisturizing effect on the skin.\u0000\u0000\u0000\u0000To utilize the tubular calyx of Nyctanthes arbor- tristis as an economical source of crocin and Coriandrum sativum seed oil as a source of petroselinic acid for the development of a stable phytosomal gel formulation and to evaluate its sunscreen and moisturizing activities.\u0000\u0000\u0000\u0000To utilize tubular calyx of Nyctanthes arbor- tristis as an economical source of crocin and Coriandrum sativum seed oil as source of petroselinic acid, for development of a stable phytosomal gel formulation and to evaluate its sunscreen and moisturizing activities.\u0000\u0000\u0000\u0000Phytosomes of standardized crocin-rich extract and petroselinic acid were prepared separately by lipid film hydration technique. The phytosomes were then incorporated into a gel base prepared from dehydroxanthan gum, and it was evaluated for in-vitro sunscreen activity by using Mansur’s equation. Moisturizing effect of the phytosomal gel was evaluated on 10 healthy female volunteers with their informed consent, and the water content of the stratum corneum was measured by using a Digital Moisture detector pen before and 5 hours later the application of the gel.\u0000\u0000\u0000\u0000Mean initial moisture content of the skin was found to be 30.08 %, which was significantly (P< 0.05) raised to 45.59% at the end of 5 hours. Sun Protection Factor was found to be 15.09 and with a Boot Star rating of 2.\u0000\u0000\u0000\u0000Mean initial moisture content of skin was found to be 30.08 %, which was significantly (P< 0.05) raised to 45.59% at the end of 5 hours. Sun Protection Factor was found to be 15.09 and with Boot Star rating of 2.\u0000\u0000\u0000\u0000Entrapping the phytoconstituents in vesicles increased stability, and the formulation was found to have moderate protection and a good moisturizing effect on the skin.\u0000\u0000\u0000\u0000Entrapping the phytoconstituents in vesicles increased stability and the formulation was found to have moderate protection and good moisturizing effect on skin.\u0000","PeriodicalId":10817,"journal":{"name":"Current Cosmetic Science","volume":"64 6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77427503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-20DOI: 10.2174/2666779702666230320125811
H. Kitagaki
The proportion of the elderly in the population is increasing in many developed countries, and Japan has one of the oldest populations in the world. Therefore, health care for the elderly is becoming a serious issue in Japan. Skin health is a significant concern in maintaining the quality of life (QOL) in elderly people and those requiring long-term care. The skin deteriorates and becomes fragile in elderly individuals, and the accompanying increase in skin wrinkles is caused by the degradation of structural proteins in the dermis, collagen, and elastin fibers. In addition, skin aging occurs due to genetic factors and UV. Xerosis and dry skin are the primary skin problems in the elderly. Dry skin occurs frequently in elderly women, as sebaceous glands decrease with age, while the skin of elderly men tends to have a high lipid content. Skin wrinkles and blemishes increase with age. Inflammation frequently occurs in the dermis of the elderly person. Skin cancer is a serious threat to elderly people, as skin pH increases with age. Therefore, it is important to understand the health characteristics of elderly people to improve their QOL. The skin profiles of elderly people and those requiring long-term care have many associated problems. This situation is especially serious in Japan due to the ratio of elderly people showing an increasing trend. Elderly people requiring long-term care also experience skin problems caused by pressure ulcers and diapers. Microbial and fungal infections are also common in aged people. In this review, we have discussed the skin problems associated with aging and long-term care.
{"title":"Skin Health of the Elderly and People in Long-term Care","authors":"H. Kitagaki","doi":"10.2174/2666779702666230320125811","DOIUrl":"https://doi.org/10.2174/2666779702666230320125811","url":null,"abstract":"\u0000\u0000The proportion of the elderly in the population is increasing in many developed countries, and Japan has one of the oldest populations in the world. Therefore, health care for the elderly is becoming a serious issue in Japan.\u0000Skin health is a significant concern in maintaining the quality of life (QOL) in elderly people and those requiring long-term care. The skin deteriorates and becomes fragile in elderly individuals, and the accompanying increase in skin wrinkles is caused by the degradation of structural proteins in the dermis, collagen, and elastin fibers. In addition, skin aging occurs due to genetic factors and UV. Xerosis and dry skin are the primary skin problems in the elderly. Dry skin occurs frequently in elderly women, as sebaceous glands decrease with age, while the skin of elderly men tends to have a high lipid content. Skin wrinkles and blemishes increase with age. Inflammation frequently occurs in the dermis of the elderly person. Skin cancer is a serious threat to elderly people, as skin pH increases with age.\u0000Therefore, it is important to understand the health characteristics of elderly people to improve their QOL.\u0000The skin profiles of elderly people and those requiring long-term care have many associated problems. This situation is especially serious in Japan due to the ratio of elderly people showing an increasing trend. Elderly people requiring long-term care also experience skin problems caused by pressure ulcers and diapers. Microbial and fungal infections are also common in aged people. In this review, we have discussed the skin problems associated with aging and long-term care.\u0000","PeriodicalId":10817,"journal":{"name":"Current Cosmetic Science","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84017302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：