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Comprehensive Factors for Predicting the Complications of DiabetesMellitus: A Systematic Review. 预测糖尿病并发症的综合因素:系统回顾
IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-01-01 DOI: 10.2174/0115733998271863231116062601
Madurapperumage Anuradha Erandathi, William Yu Chung Wang, Michael Mayo, Ching-Chi Lee

Background: This article focuses on extracting a standard feature set for predicting the complications of diabetes mellitus by systematically reviewing the literature. It is conducted and reported by following the guidelines of PRISMA, a well-known systematic review and meta-analysis method. The research articles included in this study are extracted using the search engine "Web of Science" over eight years. The most common complications of diabetes, diabetic neuropathy, retinopathy, nephropathy, and cardiovascular diseases are considered in the study.

Method: The features used to predict the complications are identified and categorised by scrutinising the standards of electronic health records.

Result: Overall, 102 research articles have been reviewed, resulting in 59 frequent features being identified. Nineteen attributes are recognised as a standard in all four considered complications, which are age, gender, ethnicity, weight, height, BMI, smoking history, HbA1c, SBP, eGFR, DBP, HDL, LDL, total cholesterol, triglyceride, use of insulin, duration of diabetes, family history of CVD, and diabetes. The existence of a well-accepted and updated feature set for health analytics models to predict the complications of diabetes mellitus is a vital and contemporary requirement. A widely accepted feature set is beneficial for benchmarking the risk factors of complications of diabetes.

Conclusion: This study is a thorough literature review to provide a clear state of the art for academicians, clinicians, and other stakeholders regarding the risk factors and their importance.

背景:本文主要通过系统回顾文献,提取用于预测糖尿病并发症的标准特征集。研究遵循著名的系统综述和荟萃分析方法--PRISMA 指南进行并报告。本研究收录的研究文章是通过搜索引擎 "Web of Science "提取的,历时八年。研究考虑了糖尿病最常见的并发症、糖尿病神经病变、视网膜病变、肾病和心血管疾病:方法:通过仔细研究电子健康记录的标准,确定用于预测并发症的特征并进行分类:结果:共查阅了 102 篇研究文章,确定了 59 个常见特征。在所有四种并发症中,有 19 个特征被认为是标准特征,它们是年龄、性别、种族、体重、身高、体重指数、吸烟史、HbA1c、SBP、eGFR、DBP、高密度脂蛋白、低密度脂蛋白、总胆固醇、甘油三酯、使用胰岛素、糖尿病病程、心血管疾病家族史和糖尿病。对于预测糖尿病并发症的健康分析模型来说,拥有一套广为接受且不断更新的特征集是一项至关重要的现代要求。一套广为接受的特征集有利于为糖尿病并发症的风险因素设定基准:本研究是一项全面的文献综述,旨在为学者、临床医生和其他利益相关者提供有关风险因素及其重要性的清晰现状。
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引用次数: 0
From Gut to Glucose: A Comprehensive Review on Functional Foods and Dietary Interventions for Diabetes Management. 从肠道到葡萄糖:功能性食品和糖尿病饮食干预的综合综述。
IF 3.3 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-01-01 DOI: 10.2174/0115733998266653231005072450
Nirali Patel, Susha Dinesh, Sameer Sharma

Background: In the realm of diabetes research, considerable attention has been directed toward elucidating the intricate interplay between the gastrointestinal tract and glucose regulation. The gastrointestinal tract, once exclusively considered for its role in digestion and nutrient assimilation, is presently acknowledged as a multifaceted ecosystem with regulatory supremacy over metabolic homeostasis and glucose metabolism. Recent studies indicate that alterations in the composition and functionality of the gut microbiota could potentially influence the regulation of glucose levels and glucose homeostasis in the body. Dysbiosis, characterized by perturbations in the equilibrium of gut microbial constituents, has been irrevocably linked to an augmented risk of diabetes mellitus (DM). Moreover, research has revealed the potential influence of the gut microbiota on important factors, like inflammation and insulin sensitivity, which are key contributors to the onset and progression of diabetes. The key protagonists implicated in the regulation of glucose encompass the gut bacteria, gut barrier integrity, and the gut-brain axis. A viable approach to enhance glycemic control while concurrently mitigating the burden of comorbidities associated with diabetes resides in the strategic manipulation of the gut environment through adapted dietary practices.

Objective: This review aimed to provide a deep understanding of the complex relationship between gut health, glucose metabolism, and diabetes treatment.

Conclusion: This study has presented an exhaustive overview of dietary therapies and functional foods that have undergone extensive research to explore their potential advantages in the management of diabetes. It looks into the role of gut health in glucose regulation, discusses the impact of different dietary elements on the course of diabetes, and evaluates how well functional foods can help with glycemic control. Furthermore, it investigates the mechanistic aspects of these therapies, including their influence on insulin sensitivity, β-cell activity, and inflammation. It deliberates on the limitations and potential prospects associated with integrating functional foods into personalized approaches to diabetes care.

背景:在糖尿病研究领域,人们对阐明胃肠道和葡萄糖调节之间复杂的相互作用给予了相当大的关注。胃肠道曾经只因其在消化和营养同化中的作用而被认为是一个多方面的生态系统,目前被公认为具有高于代谢稳态和葡萄糖代谢的调节优势。最近的研究表明,肠道微生物群的组成和功能的改变可能会影响体内葡萄糖水平和葡萄糖稳态的调节。以肠道微生物成分平衡紊乱为特征的生物失调已与糖尿病(DM)风险增加不可逆转地联系在一起。此外,研究还揭示了肠道微生物群对炎症和胰岛素敏感性等重要因素的潜在影响,这些因素是糖尿病发病和进展的关键因素。参与葡萄糖调节的关键因素包括肠道细菌、肠道屏障完整性和肠脑轴。增强血糖控制同时减轻糖尿病合并症负担的一种可行方法是通过适当的饮食实践对肠道环境进行战略性控制。目的:本综述旨在深入了解肠道健康、糖代谢和糖尿病治疗之间的复杂关系。结论:本研究对饮食疗法和功能性食品进行了详尽的综述,这些食品经过了广泛的研究,以探索其在糖尿病治疗中的潜在优势。它研究了肠道健康在血糖调节中的作用,讨论了不同饮食元素对糖尿病病程的影响,并评估了功能性食物对血糖控制的帮助。此外,它还研究了这些疗法的机制方面,包括它们对胰岛素敏感性、β细胞活性和炎症的影响。它探讨了将功能性食品纳入糖尿病个性化护理方法的局限性和潜在前景。
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引用次数: 0
New Horizons in Diabetic Neuropathies: An Updated Review on their Pathology, Diagnosis, Mechanism, Screening Techniques, Pharmacological, and Future Approaches. 糖尿病神经病的新视野:对其病理学、诊断、机制、筛选技术、药理学和未来方法的最新综述。
IF 3.3 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-01-01 DOI: 10.2174/0115733998242299231011181615
Namra Aziz, Biswajit Dash, Pranay Wal, Prachi Kumari, Poonam Joshi, Ankita Wal

Background: One of the largest problems for global public health is diabetes mellitus (DM) and its micro and macrovascular consequences. Although prevention, diagnosis, and treatment have generally improved, its incidence is predicted to keep rising over the coming years. Due to the intricacy of the molecular mechanisms, which include inflammation, oxidative stress, and angiogenesis, among others, discovering treatments to stop or slow the course of diabetic complications is still a current unmet need.

Methods: The pathogenesis and development of diabetic neuropathies may be explained by a wide variety of molecular pathways, hexosamine pathways, such as MAPK pathway, PARP pathway, oxidative stress pathway polyol (sorbitol) pathway, cyclooxygenase pathway, and lipoxygenase pathway. Although diabetic neuropathies can be treated symptomatically, there are limited options for treating the underlying cause.

Result: Various pathways and screening models involved in diabetic neuropathies are discussed, along with their possible outcomes. Moreover, both medicinal and non-medical approaches to therapy are also explored.

Conclusion: This study highlights the probable involvement of several processes and pathways in the establishment of diabetic neuropathies and presents in-depth knowledge of new therapeutic approaches intended to stop, delay, or reverse different types of diabetic complications.

背景:全球公共卫生面临的最大问题之一是糖尿病及其对微血管和大血管的影响。尽管预防、诊断和治疗总体上有所改善,但预计其发病率在未来几年将继续上升。由于分子机制的复杂性,包括炎症、氧化应激和血管生成等,发现阻止或减缓糖尿病并发症进程的治疗方法仍然是目前尚未满足的需求。方法:糖尿病神经病变的发病机制和发展可以通过多种分子途径、己糖胺途径来解释,如MAPK途径、PARP途径、氧化应激途径、多元醇(山梨醇)途径、环氧合酶途径和脂氧合酶途径。尽管糖尿病神经病变可以通过症状进行治疗,但治疗潜在病因的选择有限。结果:讨论了糖尿病神经病变的各种途径和筛选模型,以及它们可能的结果。此外,还探讨了药物和非药物治疗方法。结论:本研究强调了几种过程和途径可能参与糖尿病神经病变的建立,并对旨在阻止、延迟或逆转不同类型糖尿病并发症的新治疗方法提供了深入的了解。
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引用次数: 0
Novel Approaches for the Management of Type 2 Diabetes Mellitus: An Update. 治疗2型糖尿病的新方法:最新进展。
IF 3.3 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-01-01 DOI: 10.2174/0115733998261903230921102620
Abhishek Kumar, Rupa Mazumder, Anjna Rani, Pratibha Pandey, Navneet Khurana

Diabetes mellitus is an irreversible, chronic metabolic disorder indicated by hyperglycemia. It is now considered a worldwide pandemic. T2DM, a spectrum of diseases initially caused by tissue insulin resistance and slowly developing to a state characterized by absolute loss of secretory action of the β cells of the pancreas, is thought to be caused by reduced insulin secretion, resistance to tissue activities of insulin, or a combination of both. Insulin secretagogues, biguanides, insulin sensitizers, alpha-glucosidase inhibitors, incretin mimetics, amylin antagonists, and sodium-glucose co-transporter-2 (SGLT2) inhibitors are the main medications used to treat T2DM. Several of these medication's traditional dosage forms have some disadvantages, including frequent dosing, a brief half-life, and limited absorption. Hence, attempts have been made to develop new drug delivery systems for oral antidiabetics to ameliorate the difficulties associated with conventional dosage forms. In comparison to traditional treatments, this review examines the utilization of various innovative therapies (such as microparticles, nanoparticles, liposomes, niosomes, phytosomes, and transdermal drug delivery systems) to improve the distribution of various oral hypoglycemic medications. In this review, we have also discussed some new promising candidates that have been approved recently by the US Food and Drug Administration for the treatment of T2DM, like semaglutide, tirzepatide, and ertugliflozin. They are used as a single therapy and also as combination therapy with drugs like metformin and sitagliptin.

糖尿病是一种以高血糖为标志的不可逆的慢性代谢紊乱。它现在被认为是一种全球性的流行病。T2DM是一系列最初由组织胰岛素抵抗引起的疾病,并缓慢发展到胰腺β细胞分泌作用完全丧失的状态,被认为是由胰岛素分泌减少、胰岛素组织活性抵抗或两者结合引起的。胰岛素促分泌剂、双胍、胰岛素增敏剂、α-葡萄糖苷酶抑制剂、肠促胰岛素模拟物、胰淀素拮抗剂和钠-葡萄糖共转运蛋白-2(SGLT2)抑制剂是用于治疗T2DM的主要药物。这些药物的几种传统剂型有一些缺点,包括给药频繁、半衰期短和吸收有限。因此,已经尝试开发用于口服抗糖尿病药物的新的药物递送系统,以改善与传统剂型相关的困难。与传统治疗方法相比,这篇综述考察了各种创新疗法(如微粒、纳米颗粒、脂质体、niosomes、植物体和透皮给药系统)的应用,以改善各种口服降糖药物的分布。在这篇综述中,我们还讨论了一些最近被美国食品和药物管理局批准用于治疗T2DM的新的有前景的候选药物,如赛马鲁肽、替西帕肽和埃图格列嗪。它们被用作单一疗法,也被用作二甲双胍和西他列汀等药物的联合疗法。
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引用次数: 0
Role of GLP-1 Receptor Agonist in Diabetic Cardio-renal Disorder: Recent Updates of Clinical and Pre-clinical Evidence. GLP-1 受体激动剂在糖尿病心肾疾病中的作用:临床和临床前证据的最新进展。
IF 3.3 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-01-01 DOI: 10.2174/1573399820666230809152148
Sanket Seksaria, Bhaskar Jyoti Dutta, Mandeep Kaur, Ghanshyam Das Gupta, Surendra H Bodakhe, Amrita Singh

Cardiovascular complications and renal disease is the growing cause of mortality in patients with diabetes. The subversive complications of diabetes such as hyperglycemia, hyperlipidemia and insulin resistance lead to an increase in the risk of myocardial infarction (MI), stroke, heart failure (HF) as well as chronic kidney disease (CKD). Among the commercially available anti-hyperglycemic agents, incretin-based medications appear to be safe and effective in the treatment of type 2 diabetes mellitus (T2DM) and associated cardiovascular and renal disease. Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have been shown to be fruitful in reducing HbA1c, blood glucose, lipid profile, and body weight in diabetic patients. Several preclinical and clinical studies revealed the safety, efficacy, and preventive advantages of GLP-1RAs against diabetes- induced cardiovascular and kidney disease. Data from cardio-renal outcome trials had highlighted that GLP-1RAs protected people with established CKD from significant cardiovascular disease, lowered the likelihood of hospitalization for heart failure (HHF), and lowered all-cause mortality. They also had a positive effect on people with end-stage renal disease (ESRD) and CKD. Beside clinical outcomes, GLP-1RAs reduced oxidative stress, inflammation, fibrosis, and improved lipid profile pre-clinically in diabetic models of cardiomyopathy and nephropathy that demonstrated the cardio-protective and reno-protective effect of GLP-1RAs. In this review, we have focused on the recent clinical and preclinical outcomes of GLP-1RAs as cardio-protective and reno-protective agents as GLP-1RAs medications have been demonstrated to be more effective in treating T2DM and diabetes-induced cardiovascular and renal disease than currently available treatments in clinics, without inducing hypoglycemia or weight gain.

心血管并发症和肾病是导致糖尿病患者死亡的日益严重的原因。高血糖、高脂血症和胰岛素抵抗等糖尿病并发症会增加心肌梗死(MI)、中风、心力衰竭(HF)和慢性肾病(CKD)的风险。在市售的降糖药物中,以增量素为基础的药物似乎在治疗 2 型糖尿病(T2DM)及相关的心血管和肾脏疾病方面安全有效。胰高血糖素样肽 1 受体激动剂(GLP-1RAs)在降低糖尿病患者的 HbA1c、血糖、血脂和体重方面效果显著。多项临床前和临床研究显示,GLP-1RAs 对糖尿病诱发的心血管疾病和肾脏疾病具有安全性、有效性和预防优势。心肾功能试验的数据显示,GLP-1RA 可保护已确诊的慢性肾脏病患者免受严重心血管疾病的困扰,降低因心力衰竭(HHF)住院的可能性,并降低全因死亡率。它们对终末期肾病(ESRD)和慢性肾脏病患者也有积极作用。除了临床疗效,GLP-1RAs 还能减少氧化应激、炎症、纤维化,并改善糖尿病心肌病和肾病模型的临床前血脂状况,这些都证明了 GLP-1RA 对心脏和肾脏的保护作用。在本综述中,我们重点介绍了 GLP-1RAs 作为心血管保护和肾脏保护药物的最新临床和临床前研究成果,因为 GLP-1RAs 药物在治疗 T2DM 和糖尿病诱发的心血管和肾脏疾病方面比目前临床上的现有治疗方法更有效,而且不会诱发低血糖或体重增加。
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引用次数: 0
The Natural Sweetener Stevia: An Updated Review on its Phytochemistry, Health Benefits, and Anti-diabetic Study. 天然甜味剂甜叶菊:关于其植物化学、健康益处和抗糖尿病研究的最新综述。
IF 3.3 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-01-01 DOI: 10.2174/1573399819666230501210803
Shraddha Patel, Archana Navale

Stevia rebaudiana Bertoni is one of the significant high qualities of non-caloric sugar substitute sweetener plants against diabetes disease. Diabetes mellitus is one of the most common metabolic diseases caused by insulin secretion defects, insulin resistance in peripheral tissues, or both. Stevia rebaudiana is a perennial shrub of the Compositae family that is grown in several places around the world. It contains a plethora of different bioactive constituents which are responsible for several activities and sweetness. This sweetness is due to the presence of steviol glycosides which is 100-300 times sweeter than sucrose. Furthermore, stevia reduces oxidative stress, lowering the risk of diabetes. Its leaves have been used to control and treat diabetes and a variety of other metabolic diseases. This review summarizes the history, bioactive constituents of S. rebaudiana extract, pharmacology, anti-diabetic activity, and its application, especially in food supplements.

甜叶菊(Stevia rebaudiana Bertoni)是一种对糖尿病有显著疗效的无热量代糖甜味剂植物。糖尿病是最常见的代谢性疾病之一,由胰岛素分泌缺陷、外周组织的胰岛素抵抗或两者共同引起。甜叶菊(Stevia rebaudiana)是一种多年生灌木,属于菊科,在世界多个地方都有种植。它含有大量不同的生物活性成分,具有多种活性和甜味。甜味是甜菊糖苷的功劳,其甜度是蔗糖的 100-300 倍。此外,甜叶菊还能减少氧化应激,降低患糖尿病的风险。甜菊叶已被用于控制和治疗糖尿病及其他多种代谢性疾病。本综述概述了甜叶菊提取物的历史、生物活性成分、药理学、抗糖尿病活性及其应用,特别是在食品补充剂中的应用。
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引用次数: 0
Synergistic Effect of Naringin and Glimepiride in Streptozotocin-induced Diabetic Rats. 柚皮苷和格列美脲对链脲佐菌素诱导的糖尿病大鼠的协同作用
IF 3.3 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-01-01 DOI: 10.2174/1573399820666230817154835
Deepankar Rath, Biswakanth Kar, Gurudutta Pattnaik, Pallishree Bhukta

Objective: Evaluation of the synergistic effect of Naringin and Glimepiride in streptozotocin (STZ)-induced diabetic rats.

Methods: Wistar rats were chosen and divided into five groups (n=6). STZ was used for the induction of diabetes. The combination of naringin and glimepiride was administered to diabetic rats. The changes in fasting blood sugar, body weight, Hb, HbA1c, and creatinine were evaluated, and urine was collected and the volume was observed. The lipid profiles like TC, HDL, LDL, and TG were measured. The biochemical parameters SGOT, SGPT, and ALP were analysed. Besides, endogenous antioxidant parameters like SOD, GSH, and catalase were also assessed. Lastly, the histopathological study of the beta cells in islets of the pancreas, glomerulus, and tubules of kidney and liver cells was conducted in all groups.

Results: The result shows significant reduction (p<0.001) of blood sugar in the naringin and glimepiride-treated group when compared with the control group (diabetes). Additionally, the combination of Naringin (100 mg/kg) and Glimepiride (0.1 mg/kg) significantly restores the creatinine levels and urine volumes, SGOT, SGPT, and ALP when compared to a single dose of administration. Further, the abnormal lipid profile levels (TC, LDL, TG, and HDL), and endogenous antioxidant enzymes (SOD, GSH, catalase) in diabetic control rats were restored to normal levels in a significant manner. The histopathological result reveals significant alterations, including hypertrophy of islets and mild degeneration, renal necrosis, and inflammation of hepatocytes.

Conclusion: A synergistic effect of Naringin and glimepiride was observed during the estimation of various biochemical parameters like body weight, fasting blood sugar, creatinine, urine level, TG, total cholesterol, SGOT, SGPT, ALP, Insulin, HbA1c, antioxidant parameters like SOD, GSH, and catalase in STZ-induced diabetic rats. Further, the combination of therapy improves the protective effect of the pancreas, kidney, and liver, suggesting a potential antidiabetic effect.

目的评估柚皮苷和格列美脲对链脲佐菌素(STZ)诱导的糖尿病大鼠的协同作用:选取 Wistar 大鼠,将其分为 5 组(n=6)。用 STZ 诱导糖尿病大鼠。给糖尿病大鼠服用柚皮苷和格列美脲复方制剂。评估空腹血糖、体重、血红蛋白、HbA1c 和肌酐的变化,收集尿液并观察尿量。测量了血脂谱,如 TC、HDL、LDL 和 TG。分析了生化指标 SGOT、SGPT 和 ALP。此外,还评估了 SOD、GSH 和过氧化氢酶等内源性抗氧化参数。最后,对所有组的胰岛β细胞、肾小球、肾小管和肝细胞进行了组织病理学研究:结果:结果显示胰岛β细胞明显减少(p在对 STZ 诱导的糖尿病大鼠的体重、空腹血糖、肌酐、尿液水平、TG、总胆固醇、SGOT、SGPT、ALP、胰岛素、HbA1c、SOD、GSH 和过氧化氢酶等抗氧化参数进行评估时,观察到了柚皮苷和格列美脲的协同作用。此外,联合疗法还能提高对胰腺、肾脏和肝脏的保护作用,这表明它具有潜在的抗糖尿病作用。
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引用次数: 0
Lipids: A Major Culprit in Diabetic Nephropathy. 脂质:糖尿病肾病的罪魁祸首。
IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-01-01 DOI: 10.2174/0115733998259273231101052549
Ankita Beniwal, Jasmine Chaudhary Jain, Akash Jain

The pathophysiology of diabetic nephropathy (DN) is too complex and involves a variety of pathways and mediators. Hyperglycaemia and dyslipidemia are identified as major risk factors for diabetic nephropathy. Various studies revealed the fact that dyslipidemia is a major contributor to the process of diabetic nephropathy. Dyslipidemia refers to abnormal lipid levels. Lipids like LDL, free fatty acids, abnormal lipoproteins, ceramides, etc., are unsafe for kidneys. They target proximal tubular epithelial cells, podocytes, and tubulointerstitial tissues through biochemical changes, especially by enhancing the release of reactive oxygen species (ROS) and lipid peroxidation, endorsing tissue inflammation and mitochondrial damage, which give rise to nephropathy. Major lipid targets identified are SREBP1, LXR, FXR PPAR, CD-36, PKc, AGE/RAGE pathway, and ferroptosis. The drug acting on these targets has shown improvement in DN patients. Various preclinical and clinical studies support the fact that hyperlipidemic agents are promising targets for DN. Therefore, in conjunction with other standard therapies, drugs acting on dyslipidemia can be added as a part of the regimen in order to prevent the incidence of ESRD and CVD.

糖尿病肾病(DN)的病理生理非常复杂,涉及多种途径和介质。高血糖和血脂异常是糖尿病肾病的主要危险因素。各种研究表明,血脂异常是糖尿病肾病过程的主要因素。血脂异常是指血脂水平异常。像低密度脂蛋白、游离脂肪酸、异常脂蛋白、神经酰胺等脂质对肾脏是不安全的。它们通过生化改变作用于近端小管上皮细胞、足细胞和小管间质组织,特别是通过增强活性氧(ROS)的释放和脂质过氧化作用,促进组织炎症和线粒体损伤,从而引起肾病。确定的主要脂质靶点有SREBP1、LXR、FXR、PPAR、CD-36、PKc、AGE/RAGE通路和铁沉。作用于这些靶点的药物对DN患者有改善作用。各种临床前和临床研究支持这样一个事实,即高脂血症药物是DN的有希望的靶点。因此,与其他标准疗法结合,可将作用于血脂异常的药物作为治疗方案的一部分,以预防ESRD和CVD的发生。
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引用次数: 0
The Need for Early Screening of Diabetic Peripheral Neuropathy and Diabetic Foot in MENA Region: A Review. 中东和北非地区早期筛查糖尿病周围神经病变和糖尿病足的必要性:综述。
IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-01-01 DOI: 10.2174/1573399820666230612141250
Imen Regai, Meruna Bose, Animesh Hazari, Praveen Kumar Kandakueti

Background: Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus. Among all complications of DPN, diabetic foot (DF) can cause a myriad of symptoms and impact the quality of life. This study aimed to review the prevalence of DPN and DF in the Middle East and North Africa (MENA) region based on the publications available. This systematic review can be a cornerstone for further research and it summarizes the literature published on the prevalence of DPN and DF for the last two decades in the MENA region.

Methodology: The databases, PubMed, ResearchGate, Scopus, Web of Science, Science Direct, CINAHL, and Cochrane were searched using relevant keywords for the study. Full articles in English since 2000, including keywords "Prevalence", "Diabetic peripheral neuropathy", "Diabetic foot", and "MENA region" were reviewed in two phases. All authors screened the titles and abstracts of the articles individually, which was followed by a screening of full texts. A consensus was made among all the authors for the final selection of the articles based on the eligibility criteria.

Results: Ten selected articles on the prevalence of DPN were reviewed in the first phase of the study, which reported varying prevalence rates among the different countries of the MENA region ranging from 9% to 61%. In the second phase, only two articles on DF prevalence were shortlisted. They reported the prevalence of DF as 4.6% and 18.1% in Jordan and Sudan, respectively.

Conclusion: The prevalence of DPN in the MENA region is varied within a short period of time and the reported prevalence of DF is limited. This study projects a strong need of establishing early screening strategies for DPN and DF to prevent further complications and decrease healthcare burden.

背景:糖尿病周围神经病变(DPN)是糖尿病最常见的并发症:糖尿病周围神经病变(DPN)是糖尿病最常见的并发症。在糖尿病周围神经病变的所有并发症中,糖尿病足(DF)可引起多种症状并影响生活质量。本研究旨在根据现有出版物回顾中东和北非地区 DPN 和 DF 的发病率。本系统性综述可作为进一步研究的基石,它总结了过去二十年中东和北非地区有关 DPN 和 DF 患病率的文献:本研究使用相关关键词搜索了 PubMed、ResearchGate、Scopus、Web of Science、Science Direct、CINAHL 和 Cochrane 等数据库。研究人员分两个阶段审查了 2000 年以来的英文全文,包括关键词 "患病率"、"糖尿病周围神经病变"、"糖尿病足 "和 "中东和北非地区"。所有作者分别对文章的标题和摘要进行筛选,然后对全文进行筛选。所有作者根据资格标准达成共识,最终选定文章:研究的第一阶段审查了 10 篇关于 DPN 患病率的精选文章,这些文章报告了中东和北非地区不同国家的不同患病率,患病率从 9% 到 61% 不等。在第二阶段,仅筛选出两篇关于 DF 患病率的文章。这两篇文章报告说,约旦和苏丹的 DF 患病率分别为 4.6% 和 18.1%:结论:中东和北非地区的 DPN 患病率在短时间内变化很大,而 DF 患病率的报告却很有限。这项研究表明,亟需建立 DPN 和 DF 的早期筛查策略,以预防进一步的并发症并减轻医疗负担。
{"title":"The Need for Early Screening of Diabetic Peripheral Neuropathy and Diabetic Foot in MENA Region: A Review.","authors":"Imen Regai, Meruna Bose, Animesh Hazari, Praveen Kumar Kandakueti","doi":"10.2174/1573399820666230612141250","DOIUrl":"10.2174/1573399820666230612141250","url":null,"abstract":"<p><strong>Background: </strong>Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus. Among all complications of DPN, diabetic foot (DF) can cause a myriad of symptoms and impact the quality of life. This study aimed to review the prevalence of DPN and DF in the Middle East and North Africa (MENA) region based on the publications available. This systematic review can be a cornerstone for further research and it summarizes the literature published on the prevalence of DPN and DF for the last two decades in the MENA region.</p><p><strong>Methodology: </strong>The databases, PubMed, ResearchGate, Scopus, Web of Science, Science Direct, CINAHL, and Cochrane were searched using relevant keywords for the study. Full articles in English since 2000, including keywords \"Prevalence\", \"Diabetic peripheral neuropathy\", \"Diabetic foot\", and \"MENA region\" were reviewed in two phases. All authors screened the titles and abstracts of the articles individually, which was followed by a screening of full texts. A consensus was made among all the authors for the final selection of the articles based on the eligibility criteria.</p><p><strong>Results: </strong>Ten selected articles on the prevalence of DPN were reviewed in the first phase of the study, which reported varying prevalence rates among the different countries of the MENA region ranging from 9% to 61%. In the second phase, only two articles on DF prevalence were shortlisted. They reported the prevalence of DF as 4.6% and 18.1% in Jordan and Sudan, respectively.</p><p><strong>Conclusion: </strong>The prevalence of DPN in the MENA region is varied within a short period of time and the reported prevalence of DF is limited. This study projects a strong need of establishing early screening strategies for DPN and DF to prevent further complications and decrease healthcare burden.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":"e120623217893"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9621011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in the Management of Diabetes and Overweight using Incretin-based Pharmacotherapies. 以肠促胰岛素为基础的药物治疗糖尿病和超重的进展。
IF 3.3 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-01-01 DOI: 10.2174/0115733998256797231009062744
Shatrudhan Prajapati

Throughout the previous three decades, the secretion of glucagon-like peptide-1 hormone has attracted much attention to attain possible therapy goals for the treatment of both hypoglycaemic along type II diabetes militates and overweight. The pharmaceutical generation of peptides similar to hypoglycaemia-based medicines is exemplified by agonists of the GLP- 1R (Glucagon-like peptide-1 receptors). Pharmacokinetic profiles are continuously being improved, beginning with the native hormone with a two- to three-minute quarter and progressing through growth every day with once-drug combinations. Due to contradictory data that indicate stimulation or inhibition of the Glucagon-like peptide receptor, the Glucose-dependent insulin tropic peptide receptor offers favorable effects on systemic metabolism. The recent Glp-1R (Glucagon-like peptide-1 receptor-) targeting monomolecular drugs has demonstrated therapeutic effectiveness and has stoked interest in Glucose-dependent insulin tropic polypeptide antagonism as a treatment for overweight and diabetes mellitus. These drugs have been shown to dramatically improve carbohydrates with body weight management in sick people who have obesity and type II diabetes mellitus. In this study, recent breakthroughs in compelling therapeutic interventions are discussed, and the biology and pharmacology of the glucose-like peptide are reviewed.

在过去的三十年中,胰高血糖素样肽-1激素的分泌引起了人们的广泛关注,以达到治疗低血糖和超重的可能治疗目标。与降糖药物类似的肽的药物生成以GLP- 1R(胰高血糖素样肽-1受体)激动剂为例。药代动力学特征正在不断得到改善,从原生激素开始,每隔2到3分钟服用一次,然后每天服用一次药物组合。由于相互矛盾的数据表明刺激或抑制胰高血糖素样肽受体,葡萄糖依赖性胰岛素肽受体对全身代谢有良好的影响。最近针对Glp-1R(胰高血糖素样肽-1受体-)的单分子药物已显示出治疗效果,并引起了人们对葡萄糖依赖性胰岛素多肽拮抗剂作为超重和糖尿病治疗方法的兴趣。这些药物已被证明可以显著改善患有肥胖症和II型糖尿病的患者的碳水化合物和体重管理。在本研究中,讨论了最近在引人注目的治疗干预方面的突破,并对葡萄糖样肽的生物学和药理学进行了综述。
{"title":"Advances in the Management of Diabetes and Overweight using Incretin-based Pharmacotherapies.","authors":"Shatrudhan Prajapati","doi":"10.2174/0115733998256797231009062744","DOIUrl":"10.2174/0115733998256797231009062744","url":null,"abstract":"<p><p>Throughout the previous three decades, the secretion of glucagon-like peptide-1 hormone has attracted much attention to attain possible therapy goals for the treatment of both hypoglycaemic along type II diabetes militates and overweight. The pharmaceutical generation of peptides similar to hypoglycaemia-based medicines is exemplified by agonists of the GLP- 1R (Glucagon-like peptide-1 receptors). Pharmacokinetic profiles are continuously being improved, beginning with the native hormone with a two- to three-minute quarter and progressing through growth every day with once-drug combinations. Due to contradictory data that indicate stimulation or inhibition of the Glucagon-like peptide receptor, the Glucose-dependent insulin tropic peptide receptor offers favorable effects on systemic metabolism. The recent Glp-1R (Glucagon-like peptide-1 receptor-) targeting monomolecular drugs has demonstrated therapeutic effectiveness and has stoked interest in Glucose-dependent insulin tropic polypeptide antagonism as a treatment for overweight and diabetes mellitus. These drugs have been shown to dramatically improve carbohydrates with body weight management in sick people who have obesity and type II diabetes mellitus. In this study, recent breakthroughs in compelling therapeutic interventions are discussed, and the biology and pharmacology of the glucose-like peptide are reviewed.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":"e131123223544"},"PeriodicalIF":3.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92153097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Current diabetes reviews
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