首页 > 最新文献

Current diabetes reviews最新文献

英文 中文
Efficacy of Adjunctive Local Antimicrobials to Non-Surgical Periodontal Therapy in Pocket Reduction and Glycemic Control of Patients with Type 2 Diabetes: A Network Meta-Analysis. 非手术牙周治疗中辅助局部抗菌药对缩小 2 型糖尿病患者牙周袋和控制血糖的疗效:网络 Meta 分析。
IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-03 DOI: 10.2174/0115733998320667240805045742
Domitilla Marchiori Sant'Anna Leal de Oliveira, Ana Luiza Magalhães de Souza, Getúlio da Rocha Nogueira Filho, Carolina Castro Martins-Pfeifer, Cristine Miron Stefani

Objective: This network meta-analysis [NMA] investigated the efficacy of adjunctive use of subgingivally delivered antimicrobials to non-surgical periodontal therapy [NSPT] in the glycemic control and periodontal pocket depth (PPD) reduction in patients with type 2 diabetes (T2D).

Methods: Seven databases, grey literature, and registry platforms were searched up to February 2024 to identify randomized clinical trials (RCT) fulfilling the eligibility criteria. The risk of bias was assessed through Cochrane's tool (RoB 2). Two frequentist NMA were performed using a random-effects model to calculate mean differences (MD) as an effect measure and to quantitatively evaluate the glycated hemoglobin (HbA1c) and PPD. The certainty of evidence was assessed through the GRADE approach in a partially contextualized framework for interpreting results. Ten RCTs were included.

Results: In total, 261 patients were treated with eight different local antimicrobials adjuvants to NSPT (azithromycin gel, clarithromycin gel, tetracycline fiber or ointment, chlorhexidine gel, doxycycline nanospheres, minocycline gel, and satranidazole gel), while 249 patients received NSPT alone or associated to placebo. Considering PPD reduction (8 included studies), the best results were found after six months for satranidazole gel (MD -2.64mm; 95%CI -3.56, -1.72; moderate evidence certainty). For HbA1c control (7 included studies), doxycycline gel (MD - 0.80%; 95%CI -1.70, 0.10), chlorhexidine gel (MD -0.68%; 95%CI -1.34, -0.02), and tetracycline fiber (MD -0.62%; 95%CI -0.85, -0.39) showed promising results after three months (low evidence certainty).

Conclusion: The adjunctive use of satranidazole gel probably reduces PPD after a 6-month follow-up, while doxycycline gel, chlorhexidine gel, and tetracycline fiber may decrease HbA1c values in patients with T2D and periodontitis treated with NSPT after a 3-month follow up.

研究目的本网络荟萃分析[NMA]研究了在非手术牙周治疗[NSPT]的基础上辅助使用龈下给药抗菌剂对控制2型糖尿病(T2D)患者血糖和减少牙周袋深度(PPD)的疗效:检索了截至 2024 年 2 月的七个数据库、灰色文献和登记平台,以确定符合资格标准的随机临床试验 (RCT)。通过 Cochrane 工具(RoB 2)评估了偏倚风险。使用随机效应模型进行了两次频数主义 NMA,计算平均差 (MD) 作为效应度量,并对糖化血红蛋白 (HbA1c) 和 PPD 进行定量评估。通过 GRADE 方法对证据的确定性进行了评估,并采用部分情景化框架对结果进行解释。共纳入 10 项 RCT:共有261名患者接受了8种不同的局部抗菌剂辅助NSPT治疗(阿奇霉素凝胶、克拉霉素凝胶、四环素纤维或软膏、洗必泰凝胶、多西环素纳米球、米诺环素凝胶和沙格雷尼达唑凝胶),249名患者单独接受了NSPT治疗或与安慰剂联合使用。考虑到PPD的降低(纳入了8项研究),6个月后发现萨他尼达唑凝胶的效果最好(MD -2.64mm;95%CI -3.56,-1.72;中度证据确定性)。对于 HbA1c 控制(纳入 7 项研究),多西环素凝胶(MD -0.80%;95%CI -1.70, 0.10)、洗必泰凝胶(MD -0.68%;95%CI -1.34, -0.02)和四环素纤维(MD -0.62%;95%CI -0.85, -0.39)在三个月后显示出良好的效果(低证据确定性):结论:在6个月的随访后,辅助使用萨他尼达唑凝胶可能会降低PPD,而多西环素凝胶、洗必泰凝胶和四环素纤维在3个月的随访后可能会降低接受NSPT治疗的T2D和牙周炎患者的HbA1c值。
{"title":"Efficacy of Adjunctive Local Antimicrobials to Non-Surgical Periodontal Therapy in Pocket Reduction and Glycemic Control of Patients with Type 2 Diabetes: A Network Meta-Analysis.","authors":"Domitilla Marchiori Sant'Anna Leal de Oliveira, Ana Luiza Magalhães de Souza, Getúlio da Rocha Nogueira Filho, Carolina Castro Martins-Pfeifer, Cristine Miron Stefani","doi":"10.2174/0115733998320667240805045742","DOIUrl":"https://doi.org/10.2174/0115733998320667240805045742","url":null,"abstract":"<p><strong>Objective: </strong>This network meta-analysis [NMA] investigated the efficacy of adjunctive use of subgingivally delivered antimicrobials to non-surgical periodontal therapy [NSPT] in the glycemic control and periodontal pocket depth (PPD) reduction in patients with type 2 diabetes (T2D).</p><p><strong>Methods: </strong>Seven databases, grey literature, and registry platforms were searched up to February 2024 to identify randomized clinical trials (RCT) fulfilling the eligibility criteria. The risk of bias was assessed through Cochrane's tool (RoB 2). Two frequentist NMA were performed using a random-effects model to calculate mean differences (MD) as an effect measure and to quantitatively evaluate the glycated hemoglobin (HbA1c) and PPD. The certainty of evidence was assessed through the GRADE approach in a partially contextualized framework for interpreting results. Ten RCTs were included.</p><p><strong>Results: </strong>In total, 261 patients were treated with eight different local antimicrobials adjuvants to NSPT (azithromycin gel, clarithromycin gel, tetracycline fiber or ointment, chlorhexidine gel, doxycycline nanospheres, minocycline gel, and satranidazole gel), while 249 patients received NSPT alone or associated to placebo. Considering PPD reduction (8 included studies), the best results were found after six months for satranidazole gel (MD -2.64mm; 95%CI -3.56, -1.72; moderate evidence certainty). For HbA1c control (7 included studies), doxycycline gel (MD - 0.80%; 95%CI -1.70, 0.10), chlorhexidine gel (MD -0.68%; 95%CI -1.34, -0.02), and tetracycline fiber (MD -0.62%; 95%CI -0.85, -0.39) showed promising results after three months (low evidence certainty).</p><p><strong>Conclusion: </strong>The adjunctive use of satranidazole gel probably reduces PPD after a 6-month follow-up, while doxycycline gel, chlorhexidine gel, and tetracycline fiber may decrease HbA1c values in patients with T2D and periodontitis treated with NSPT after a 3-month follow up.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evidence of a Bi-Directional Relationship between Arterial Stiffness and Diabetes: A Systematic Review and Meta-Analysis of Cohort Studies. 动脉僵化与糖尿病之间存在双向关系的证据:队列研究的系统回顾和元分析》。
IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-02 DOI: 10.2174/0115733998298294240820070528
Angela L Beros, John D Sluyter, Robert Kr Scragg

Background: There are numerous cross-sectional studies showing an association between arterial stiffness and diabetes, but the temporality of the association is unclear.

Objective: To investigate the temporal relationship between arterial stiffness and diabetes.

Methods: We searched MEDLINE and Embase from inception to 31 August 2023, to identify cohort studies that assessed whether arterial stiffness, as measured by pulse wave velocity (PWV), was predictive of the development of diabetes and vice versa. We summarised study data, and where possible undertook meta-analysis.

Results: We identified 19 studies that included people with type 1, type 2 and gestational diabetes. All 11 studies investigating arterial stiffness as a predictor of diabetes found a significant relationship. Six of those studies were suitable for meta-analysis. The risk of developing diabetes was greater in people with higher PWV at baseline than lower PWV (RR = 2.14, 95%CI 1.65 to 2.79, p < 0.00001) and the mean difference in baseline PWV was higher in people who developed diabetes than those who did not (mean difference: 0.77 m/s, 95%CI 0.47 to 1.06, p < 0.00001). Of 8 studies investigating diabetes as a predictor of arterial stiffness, 7 found a significant relationship.

Conclusion: There is evidence of a bidirectional relationship between arterial stiffness and diabetes. Arterial stiffness may provide a causal link between diabetes and future cardiovascular disease.

背景:许多横断面研究显示动脉僵化与糖尿病之间存在关联,但这种关联的时间性尚不清楚:调查动脉僵化与糖尿病之间的时间关系:我们检索了从开始到 2023 年 8 月 31 日的 MEDLINE 和 Embase,以确定评估动脉僵化(通过脉搏波速度 (PWV) 测量)是否可预测糖尿病发病的队列研究,反之亦然。我们总结了研究数据,并在可能的情况下进行了荟萃分析:我们确定了 19 项研究,其中包括 1 型、2 型和妊娠糖尿病患者。所有 11 项将动脉僵化作为糖尿病预测因素的研究均发现两者之间存在显著关系。其中六项研究适合进行荟萃分析。基线脉搏波速度较高的人群罹患糖尿病的风险高于基线脉搏波速度较低的人群(RR = 2.14,95%CI 1.65 至 2.79,p < 0.00001),基线脉搏波速度的平均差异在罹患糖尿病的人群中高于未罹患糖尿病的人群(平均差异:0.77 m/s,95%CI 0.47 至 1.06,p < 0.00001)。8 项研究将糖尿病作为动脉僵化的预测因素,其中 7 项研究发现两者之间存在显著关系:结论:有证据表明动脉僵化与糖尿病之间存在双向关系。动脉僵化可能是糖尿病与未来心血管疾病之间的因果联系。
{"title":"Evidence of a Bi-Directional Relationship between Arterial Stiffness and Diabetes: A Systematic Review and Meta-Analysis of Cohort Studies.","authors":"Angela L Beros, John D Sluyter, Robert Kr Scragg","doi":"10.2174/0115733998298294240820070528","DOIUrl":"https://doi.org/10.2174/0115733998298294240820070528","url":null,"abstract":"<p><strong>Background: </strong>There are numerous cross-sectional studies showing an association between arterial stiffness and diabetes, but the temporality of the association is unclear.</p><p><strong>Objective: </strong>To investigate the temporal relationship between arterial stiffness and diabetes.</p><p><strong>Methods: </strong>We searched MEDLINE and Embase from inception to 31 August 2023, to identify cohort studies that assessed whether arterial stiffness, as measured by pulse wave velocity (PWV), was predictive of the development of diabetes and vice versa. We summarised study data, and where possible undertook meta-analysis.</p><p><strong>Results: </strong>We identified 19 studies that included people with type 1, type 2 and gestational diabetes. All 11 studies investigating arterial stiffness as a predictor of diabetes found a significant relationship. Six of those studies were suitable for meta-analysis. The risk of developing diabetes was greater in people with higher PWV at baseline than lower PWV (RR = 2.14, 95%CI 1.65 to 2.79, p < 0.00001) and the mean difference in baseline PWV was higher in people who developed diabetes than those who did not (mean difference: 0.77 m/s, 95%CI 0.47 to 1.06, p < 0.00001). Of 8 studies investigating diabetes as a predictor of arterial stiffness, 7 found a significant relationship.</p><p><strong>Conclusion: </strong>There is evidence of a bidirectional relationship between arterial stiffness and diabetes. Arterial stiffness may provide a causal link between diabetes and future cardiovascular disease.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diabetes and its Silent Partner: A Critical Review of Hyperinsulinemia and its Complications. 糖尿病及其沉默的伙伴:对高胰岛素血症及其并发症的批判性评论。
IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-26 DOI: 10.2174/0115733998311738240813110032
Imran Rashid Rangraze, Mohamed El-Tanani, Syed Arman Rabbani, Rasha Babiker, Ismail I Matalka, Manfredi Rizzo

In this complex realm of diabetes, hyperinsulinemia is no longer regarded as just a compensatory response to insulin resistance but rather has evolved into an integral feature. This comprehensive review provides a synthesis of the current literature, including various aspects associated with hyperinsulinemia in diabetic complications. Hyperinsulinemia has been shown to be more than just a compensatory mechanism, and the key findings demonstrate how hyperinsulinism affects the development of cardiovascular events as well as microvascular complications. Additionally, recognizing hyperinsulinemia as a modifiable factor, the diabetes management paradigm shifts towards cognitive ones that consider the use of lifestyle modifications in combination with newer pharmacotherapies and precision medicine approaches. These findings have crucial implications for the clinical work, requiring a careful appreciation of hyperinsulinemia's changing aspects as well as incorporation in personalized treatment protocol. In addition, the review focuses on bigger issues related to public health, showing that prevention and early diagnosis will help reduce the burden of complications. Research implications favor longitudinal studies, biomarker discovery, and the study of emerging treatment modalities; clinical practice should adopt global evaluations, patient education, and precision medicine adaptation. Finally, this critical review provides an overview of the underlying processes of hyperinsulinemia in diabetes and its overall health effects.

在糖尿病这个复杂的领域,高胰岛素血症不再仅仅被视为胰岛素抵抗的代偿反应,而是演变成了一个不可或缺的特征。这篇综述综述了当前的文献,包括与糖尿病并发症中高胰岛素血症相关的各个方面。高胰岛素血症已被证明不仅仅是一种代偿机制,主要研究结果表明了高胰岛素血症如何影响心血管事件和微血管并发症的发生。此外,由于认识到高胰岛素血症是一个可改变的因素,糖尿病的管理模式将转向认知模式,即考虑将改变生活方式与新型药物疗法和精准医疗方法相结合。这些发现对临床工作有重要影响,需要仔细了解高胰岛素血症的变化,并将其纳入个性化治疗方案。此外,综述还关注了与公共卫生相关的更大问题,表明预防和早期诊断将有助于减轻并发症的负担。纵向研究、生物标记物的发现和新兴治疗模式的研究对研究的影响是有利的;临床实践应采用全球评估、患者教育和精准医疗适应性。最后,本评论综述了糖尿病高胰岛素血症的基本过程及其对整体健康的影响。
{"title":"Diabetes and its Silent Partner: A Critical Review of Hyperinsulinemia and its Complications.","authors":"Imran Rashid Rangraze, Mohamed El-Tanani, Syed Arman Rabbani, Rasha Babiker, Ismail I Matalka, Manfredi Rizzo","doi":"10.2174/0115733998311738240813110032","DOIUrl":"https://doi.org/10.2174/0115733998311738240813110032","url":null,"abstract":"<p><p>In this complex realm of diabetes, hyperinsulinemia is no longer regarded as just a compensatory response to insulin resistance but rather has evolved into an integral feature. This comprehensive review provides a synthesis of the current literature, including various aspects associated with hyperinsulinemia in diabetic complications. Hyperinsulinemia has been shown to be more than just a compensatory mechanism, and the key findings demonstrate how hyperinsulinism affects the development of cardiovascular events as well as microvascular complications. Additionally, recognizing hyperinsulinemia as a modifiable factor, the diabetes management paradigm shifts towards cognitive ones that consider the use of lifestyle modifications in combination with newer pharmacotherapies and precision medicine approaches. These findings have crucial implications for the clinical work, requiring a careful appreciation of hyperinsulinemia's changing aspects as well as incorporation in personalized treatment protocol. In addition, the review focuses on bigger issues related to public health, showing that prevention and early diagnosis will help reduce the burden of complications. Research implications favor longitudinal studies, biomarker discovery, and the study of emerging treatment modalities; clinical practice should adopt global evaluations, patient education, and precision medicine adaptation. Finally, this critical review provides an overview of the underlying processes of hyperinsulinemia in diabetes and its overall health effects.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142079476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Low-Volume High-Intensity Interval Training (LV-HIIT) on Fatty Liver Index (FLI) and Estimated Glomerular Filtration Rate (eGFR) in Patients with Type 2 Diabetes Mellitus (T2DM). 低容量高强度间歇训练 (LV-HIIT) 对 2 型糖尿病 (T2DM) 患者脂肪肝指数 (FLI) 和估计肾小球滤过率 (eGFR) 的影响。
IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-12 DOI: 10.2174/0115733998320832240805113238
Rasoul Raesi, Saeid Kalbasi, Abbas Ali Gaeini, Maryam Haji Ghasem Kashani, Khadijeh Tajik

Background: Prevention and reduction of liver fat accumulation and maintenance of Glomerular Filtration Rate (GFR) have been proposed as important therapeutic goals in patients with Type 2 Diabetes Mellitus (T2DM).

Aim: This study aimed to determine the effect of Low-Volume High-Intensity Interval Training (LV-HIIT) on fatty liver index (FLI) and GFR estimation in patients with T2DM.

Methods: This randomized controlled trial included 80 patients with T2DM and a sedentary lifestyle, randomly divided into HIIT (n=40) and a control group (n=40). Patients with a history of T2DM for at least one year and HbA1C levels between 6.4% and 10% were selected. The intervention group underwent a 4-week LV-HIIT course, comprising 3 sessions per week, while the control group did not receive any intervention. FLI, eGFR, anthropometric measurements, and laboratory variables were assessed in all participants before and after the intervention.

Results: FLI (62.0 at baseline, 53.0 at follow-up) significantly decreased in the LV-HIIT group after the intervention, while eGFR (71.0 at baseline, 73.6 at follow-up) significantly increased (P<0.001). However, the control group showed a significant reduction only in Fasting Blood Sugar (FBS) (P<0.05). After the intervention, the LV-HIIT group had significantly lower FBS (129.0 at baseline, 121.0 at follow-up), Alanine Aminotransferase (ALT) (24.0 at baseline, 18.0 at follow-up), and Gamma-Glutamyl Transferase (GGT) (22.0 at baseline, 19.0 at follow-up), as well as higher eGFR, compared to the control group (P<0.05).

Conclusions: LV-HIIT exercise appears to be a promising and effective training method for improving FLI and eGFR in patients diagnosed with T2DM.

背景:目的:本研究旨在确定低容量高强度间歇训练(LV-HIIT)对 T2DM 患者脂肪肝指数(FLI)和 GFR 估计值的影响:这项随机对照试验包括80名T2DM患者和久坐不动的生活方式,随机分为HIIT组(40人)和对照组(40人)。患者均有至少一年的 T2DM 病史,HbA1C 水平在 6.4% 至 10% 之间。干预组接受为期 4 周的 LV-HIIT 训练,每周 3 次,对照组不接受任何干预。在干预前后,对所有参与者的 FLI、eGFR、人体测量和实验室变量进行了评估:结果:干预后,左心室-HIIT 组的 FLI(基线为 62.0,随访时为 53.0)显著下降,而 eGFR(基线为 71.0,随访时为 73.6)显著上升(结论:左心室-HIIT 运动似乎是一种有效的减肥方法:左心室-HIIT运动似乎是改善T2DM患者FLI和eGFR的有效训练方法。
{"title":"The Impact of Low-Volume High-Intensity Interval Training (LV-HIIT) on Fatty Liver Index (FLI) and Estimated Glomerular Filtration Rate (eGFR) in Patients with Type 2 Diabetes Mellitus (T2DM).","authors":"Rasoul Raesi, Saeid Kalbasi, Abbas Ali Gaeini, Maryam Haji Ghasem Kashani, Khadijeh Tajik","doi":"10.2174/0115733998320832240805113238","DOIUrl":"https://doi.org/10.2174/0115733998320832240805113238","url":null,"abstract":"<p><strong>Background: </strong>Prevention and reduction of liver fat accumulation and maintenance of Glomerular Filtration Rate (GFR) have been proposed as important therapeutic goals in patients with Type 2 Diabetes Mellitus (T2DM).</p><p><strong>Aim: </strong>This study aimed to determine the effect of Low-Volume High-Intensity Interval Training (LV-HIIT) on fatty liver index (FLI) and GFR estimation in patients with T2DM.</p><p><strong>Methods: </strong>This randomized controlled trial included 80 patients with T2DM and a sedentary lifestyle, randomly divided into HIIT (n=40) and a control group (n=40). Patients with a history of T2DM for at least one year and HbA1C levels between 6.4% and 10% were selected. The intervention group underwent a 4-week LV-HIIT course, comprising 3 sessions per week, while the control group did not receive any intervention. FLI, eGFR, anthropometric measurements, and laboratory variables were assessed in all participants before and after the intervention.</p><p><strong>Results: </strong>FLI (62.0 at baseline, 53.0 at follow-up) significantly decreased in the LV-HIIT group after the intervention, while eGFR (71.0 at baseline, 73.6 at follow-up) significantly increased (P<0.001). However, the control group showed a significant reduction only in Fasting Blood Sugar (FBS) (P<0.05). After the intervention, the LV-HIIT group had significantly lower FBS (129.0 at baseline, 121.0 at follow-up), Alanine Aminotransferase (ALT) (24.0 at baseline, 18.0 at follow-up), and Gamma-Glutamyl Transferase (GGT) (22.0 at baseline, 19.0 at follow-up), as well as higher eGFR, compared to the control group (P<0.05).</p><p><strong>Conclusions: </strong>LV-HIIT exercise appears to be a promising and effective training method for improving FLI and eGFR in patients diagnosed with T2DM.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Dietary Anthocyanins for Managing Diabetes Mellitus-Associated Complications. 膳食花青素在控制糖尿病相关并发症中的作用。
IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-12 DOI: 10.2174/0115733998322754240802063730
Priya S Mistry, Mehul R Chorawala, Bhagavathi Sundaram Sivamaruthi, Bhupendra G Prajapati, Akash Kumar, Chaiyavat Chaiyasut

Diabetes mellitus (DM) is an intricate metabolic disorder marked by persistent hyperglycemia, arising from disruptions in glucose metabolism, with two main forms, type 1 and type 2, involving distinct etiologies affecting β-cell destruction or insulin levels and sensitivity. The islets of Langerhans, particularly β-cells and α-cells, play a pivotal role in glucose regulation, and both DM types lead to severe complications, including retinopathy, nephropathy, and neuropathy. Plant-derived anthocyanins, rich in anti-inflammatory and antioxidant properties, show promise in mitigating DM-related complications, providing a potential avenue for prevention and treatment. Medicinal herbs, fruits, and vegetables, abundant in bioactive compounds like phenolics, offer diverse benefits, including glucose regulation and anti-inflammatory, antioxidant, anticancer, anti-mutagenic, and neuroprotective properties. Anthocyanins, a subgroup of polyphenols, exhibit diverse isoforms and biosynthesis involving glycosylation, making them potential natural replacements for synthetic food colorants. Clinical trials demonstrate the efficacy and safety of anthocyanins in controlling glucose, reducing oxidative stress, and enhancing insulin sensitivity in diabetic patients, emphasizing their therapeutic potential. Preclinical studies revealed their multifaceted mechanisms, positioning anthocyanins as promising bioactive compounds for managing diabetes and its associated complications, including retinopathy, nephropathy, and neuropathy.

糖尿病(DM)是一种复杂的代谢紊乱疾病,其特征是葡萄糖代谢紊乱引起的持续性高血糖,主要有两种形式,即 1 型和 2 型,涉及不同的病因,影响到 β 细胞破坏或胰岛素水平和敏感性。朗格汉斯胰岛,尤其是β细胞和α细胞,在葡萄糖调节中起着关键作用,这两种类型的糖尿病都会导致严重的并发症,包括视网膜病变、肾病和神经病变。植物提取的花青素富含抗炎和抗氧化特性,有望减轻与糖尿病相关的并发症,为预防和治疗提供了潜在的途径。药用草本植物、水果和蔬菜富含酚类等生物活性化合物,具有多种益处,包括葡萄糖调节、抗炎、抗氧化、抗癌、抗突变和神经保护特性。花青素是多酚类物质的一个亚类,具有多种异构体和涉及糖基化的生物合成,因此有可能成为合成食品着色剂的天然替代品。临床试验证明,花青素在控制糖尿病患者血糖、减少氧化应激和提高胰岛素敏感性方面具有疗效和安全性,强调了花青素的治疗潜力。临床前研究揭示了花青素的多方面机理,使花青素成为治疗糖尿病及其相关并发症(包括视网膜病变、肾病和神经病变)的有前途的生物活性化合物。
{"title":"The Role of Dietary Anthocyanins for Managing Diabetes Mellitus-Associated Complications.","authors":"Priya S Mistry, Mehul R Chorawala, Bhagavathi Sundaram Sivamaruthi, Bhupendra G Prajapati, Akash Kumar, Chaiyavat Chaiyasut","doi":"10.2174/0115733998322754240802063730","DOIUrl":"https://doi.org/10.2174/0115733998322754240802063730","url":null,"abstract":"<p><p>Diabetes mellitus (DM) is an intricate metabolic disorder marked by persistent hyperglycemia, arising from disruptions in glucose metabolism, with two main forms, type 1 and type 2, involving distinct etiologies affecting β-cell destruction or insulin levels and sensitivity. The islets of Langerhans, particularly β-cells and α-cells, play a pivotal role in glucose regulation, and both DM types lead to severe complications, including retinopathy, nephropathy, and neuropathy. Plant-derived anthocyanins, rich in anti-inflammatory and antioxidant properties, show promise in mitigating DM-related complications, providing a potential avenue for prevention and treatment. Medicinal herbs, fruits, and vegetables, abundant in bioactive compounds like phenolics, offer diverse benefits, including glucose regulation and anti-inflammatory, antioxidant, anticancer, anti-mutagenic, and neuroprotective properties. Anthocyanins, a subgroup of polyphenols, exhibit diverse isoforms and biosynthesis involving glycosylation, making them potential natural replacements for synthetic food colorants. Clinical trials demonstrate the efficacy and safety of anthocyanins in controlling glucose, reducing oxidative stress, and enhancing insulin sensitivity in diabetic patients, emphasizing their therapeutic potential. Preclinical studies revealed their multifaceted mechanisms, positioning anthocyanins as promising bioactive compounds for managing diabetes and its associated complications, including retinopathy, nephropathy, and neuropathy.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Herbal Insights: Exploring the Therapeutic Potential of Indian Dietary Herbs in Diabetic Cardiomyopathy Management. 草药透视:探索印度饮食草药在糖尿病心肌病管理中的治疗潜力。
IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-09 DOI: 10.2174/0115733998315714240801193254
Ritu, Prabhnain Kaur, Vishal Kumar Vishwakarma, Aditya Singh, Ramesh K Goyal

Background: Diabetic Cardiomyopathy (DCM) poses a substantial healthcare challenge, necessitating innovative therapeutic strategies. This review delves into the evolving role of traditional Indian dietary herbs in managing DCM, aiming to shed light on their potential contributions.

Methods: A comprehensive examination of the existing body of literature was conducted, synthesizing data from studies exploring the effects of various Indian dietary herbs on DCM. Molecular mechanisms, clinical outcomes, and safety profiles were scrutinized to establish a holistic perspective on their therapeutic potential.

Results: The review illuminates the multifaceted benefits of Indian dietary herbs in DCM management. These herbs have demonstrated efficacy in mitigating cardiac dysfunction, reducing oxidative stress, and modulating inflammatory responses. Molecular insights highlight their role in the intricate signaling pathways underlying DCM. Furthermore, their safety profiles render them promising candidates for adjunct therapy.

Conclusion: Indian dietary herbs emerge as promising allies in the battle against DCM, offering a holistic approach to the management of this intricate condition. Their cardioprotective effects, coupled with their ability to address the underlying molecular mechanisms, herald a new era in DCM therapy. This review underscores the need for further research to harness the potential of these herbs fully and provides a beacon of hope for individuals affected by DCM.

背景:糖尿病心肌病(DCM)给医疗保健带来了巨大挑战,需要创新的治疗策略。本综述深入探讨了印度传统草药在治疗 DCM 方面不断演变的作用,旨在阐明其潜在的贡献:方法:对现有文献进行了全面审查,综合了探讨各种印度草药对 DCM 影响的研究数据。对分子机制、临床结果和安全性进行了仔细研究,以全面了解它们的治疗潜力:结果:综述揭示了印度草药在 DCM 治疗中的多方面益处。这些草药在减轻心脏功能障碍、减少氧化应激和调节炎症反应方面具有疗效。分子研究表明,这些草药在 DCM 的复杂信号通路中发挥着重要作用。此外,这些草药的安全性也使其有望成为辅助疗法的候选药物:结论:印度膳食草药是抗击 DCM 的有前途的盟友,为治疗这种复杂的疾病提供了一种全面的方法。这些草药具有保护心脏的作用,而且能够解决潜在的分子机制问题,预示着 DCM 治疗进入了一个新时代。这篇综述强调了进一步研究的必要性,以充分利用这些草药的潜力,并为受 DCM 影响的个人提供了希望的灯塔。
{"title":"Herbal Insights: Exploring the Therapeutic Potential of Indian Dietary Herbs in Diabetic Cardiomyopathy Management.","authors":"Ritu, Prabhnain Kaur, Vishal Kumar Vishwakarma, Aditya Singh, Ramesh K Goyal","doi":"10.2174/0115733998315714240801193254","DOIUrl":"https://doi.org/10.2174/0115733998315714240801193254","url":null,"abstract":"<p><strong>Background: </strong>Diabetic Cardiomyopathy (DCM) poses a substantial healthcare challenge, necessitating innovative therapeutic strategies. This review delves into the evolving role of traditional Indian dietary herbs in managing DCM, aiming to shed light on their potential contributions.</p><p><strong>Methods: </strong>A comprehensive examination of the existing body of literature was conducted, synthesizing data from studies exploring the effects of various Indian dietary herbs on DCM. Molecular mechanisms, clinical outcomes, and safety profiles were scrutinized to establish a holistic perspective on their therapeutic potential.</p><p><strong>Results: </strong>The review illuminates the multifaceted benefits of Indian dietary herbs in DCM management. These herbs have demonstrated efficacy in mitigating cardiac dysfunction, reducing oxidative stress, and modulating inflammatory responses. Molecular insights highlight their role in the intricate signaling pathways underlying DCM. Furthermore, their safety profiles render them promising candidates for adjunct therapy.</p><p><strong>Conclusion: </strong>Indian dietary herbs emerge as promising allies in the battle against DCM, offering a holistic approach to the management of this intricate condition. Their cardioprotective effects, coupled with their ability to address the underlying molecular mechanisms, herald a new era in DCM therapy. This review underscores the need for further research to harness the potential of these herbs fully and provides a beacon of hope for individuals affected by DCM.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integration of Diabetes Mellitus and Hypertension on Major Cardiovascular Events: An Experience From a 15-year Follow-up Cohort Study in EMR. 糖尿病和高血压对主要心血管事件的影响:EMR 15 年跟踪队列研究的经验。
IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-08 DOI: 10.2174/0115733998304318240731051957
Masoumeh Sadeghi, Zahra Teimouri-Jervekani, Hamidreza Roohafza, Mohammad Talaei, Mohammad Hossein Paknahad, Minoo Dianatkhah, Mansoureh Boshtam, Nizal Sarrafzadegan

Introduction: Patients with hypertension and diabetes are more susceptible to cardiovascular diseases (CVD) and mortality. This study aimed to evaluate the individual and combined effects of hypertension and diabetes on cardiovascular events and mortality in a Middle Eastern population-based cohort.

Methods: Fifteen-year follow-up data were collected for 6323 adults aged 35 years and older who were free from CVD at baseline. The subjects were categorized into different groups according to hypertension and diabetes at baseline. Cox proportional hazards regression was implemented to estimate hazard ratios (HRs) of hypertension and diabetes for cardiovascular events (CVE), CVD mortality, and all-cause mortality. Population-attributable hazard fraction (PAHF) was used to assess the proportion of hazards of CVE and mortality attributable to hypertension or diabetes.

Results: The incidence rates (95% CI) of CVE, CVE mortality, and all-cause mortality in the total population were 13.77(12.84-14.77), 3.01(2.59-3.49), and 9.92(9.15-10.77) per 1000 persons per year respectively. The HR of hypertension for CVE in the diabetic population was 1.98 (1.47-2.66) with a PAHF of 27.65(15.49-39.3). When the HRs and PAHF of diabetes were evaluated in hypertensive patients, they were statistically significant for CVE, CVE mortality, and all-cause mortality.

Conclusion: Our study indicated that the joint effect of diabetes and hypertension is the dramatic increased risk of CVE. A considerable fraction of the excess risk of CVE in patients with diabetes was attributable to hypertension, on the other hand, diabetes was associated with a substantial hazard fraction of CVE and mortality in hypertensive patients.

导言:高血压和糖尿病患者更容易患心血管疾病(CVD)并导致死亡。本研究旨在评估高血压和糖尿病对中东地区人群队列中心血管事件和死亡率的个体和综合影响:收集了 6323 名年龄在 35 岁及以上、基线时无心血管疾病的成年人的 15 年随访数据。根据基线时的高血压和糖尿病将受试者分为不同的组别。采用 Cox 比例危险回归法估算高血压和糖尿病对心血管事件(CVE)、心血管疾病死亡率和全因死亡率的危险比(HRs)。人口可归因危险分数(PAHF)用于评估高血压或糖尿病导致的CVE和死亡率的危险比例:总人口中 CVE、CVE 死亡率和全因死亡率的发病率(95% CI)分别为每年每 1000 人 13.77(12.84-14.77)、3.01(2.59-3.49)和 9.92(9.15-10.77)。糖尿病人群中高血压导致 CVE 的 HR 为 1.98(1.47-2.66),PAHF 为 27.65(15.49-39.3)。当评估高血压患者的HRs和PAHF时,它们对CVE、CVE死亡率和全因死亡率均有统计学意义:我们的研究表明,糖尿病和高血压的共同作用导致 CVE 风险急剧增加。结论:我们的研究表明,糖尿病和高血压的共同作用使 CVE 风险急剧增加。糖尿病患者的 CVE 超额风险有相当一部分是由高血压造成的,另一方面,糖尿病与高血压患者的 CVE 和死亡率的危险分数有很大关系。
{"title":"Integration of Diabetes Mellitus and Hypertension on Major Cardiovascular Events: An Experience From a 15-year Follow-up Cohort Study in EMR.","authors":"Masoumeh Sadeghi, Zahra Teimouri-Jervekani, Hamidreza Roohafza, Mohammad Talaei, Mohammad Hossein Paknahad, Minoo Dianatkhah, Mansoureh Boshtam, Nizal Sarrafzadegan","doi":"10.2174/0115733998304318240731051957","DOIUrl":"https://doi.org/10.2174/0115733998304318240731051957","url":null,"abstract":"<p><strong>Introduction: </strong>Patients with hypertension and diabetes are more susceptible to cardiovascular diseases (CVD) and mortality. This study aimed to evaluate the individual and combined effects of hypertension and diabetes on cardiovascular events and mortality in a Middle Eastern population-based cohort.</p><p><strong>Methods: </strong>Fifteen-year follow-up data were collected for 6323 adults aged 35 years and older who were free from CVD at baseline. The subjects were categorized into different groups according to hypertension and diabetes at baseline. Cox proportional hazards regression was implemented to estimate hazard ratios (HRs) of hypertension and diabetes for cardiovascular events (CVE), CVD mortality, and all-cause mortality. Population-attributable hazard fraction (PAHF) was used to assess the proportion of hazards of CVE and mortality attributable to hypertension or diabetes.</p><p><strong>Results: </strong>The incidence rates (95% CI) of CVE, CVE mortality, and all-cause mortality in the total population were 13.77(12.84-14.77), 3.01(2.59-3.49), and 9.92(9.15-10.77) per 1000 persons per year respectively. The HR of hypertension for CVE in the diabetic population was 1.98 (1.47-2.66) with a PAHF of 27.65(15.49-39.3). When the HRs and PAHF of diabetes were evaluated in hypertensive patients, they were statistically significant for CVE, CVE mortality, and all-cause mortality.</p><p><strong>Conclusion: </strong>Our study indicated that the joint effect of diabetes and hypertension is the dramatic increased risk of CVE. A considerable fraction of the excess risk of CVE in patients with diabetes was attributable to hypertension, on the other hand, diabetes was associated with a substantial hazard fraction of CVE and mortality in hypertensive patients.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blood Pressure Control Among Diabetic Patients in the Eastern Mediterranean Region: A Systematic Review and Meta-Analysis 东地中海地区糖尿病患者的血压控制:系统回顾与元分析》。
IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-07-31 DOI: 10.2174/0115733998327293240729080250
Amir Hossein Behnoush, Sepehr Khosravi, Fateme Ziamanesh, Rasha Atlasi, Ali Sheidaei, Negin Sanadgol, Amirmohammad Khalaji, Ozra Tabatabaei-Malazy, Afshin Ostovar

Background: The control of blood pressure (BP) is a challenge in diabetic patientsand is associated with adverse outcomes of diabetes. In this systematic review and metaanalysis, we investigated the BP control rate among hypertensive diabetic patients in the EasternMediterranean Region (EMR) countries.

Methods: We systematically searched PubMed, Scopus, Embase, Cochrane, and Web of Science databases up to January 2023 for observational studies on BP control among hypertensivediabetic patients in all EMR countries. We included studies reporting the proportion of hypertensive, type 2 diabetic patients with controlled BP, defined as systolic/diastolic BP < 140/90 or<130/80 mmHg. Study quality was assessed using modified STROBE guidelines, and a random-effect meta-analysis was conducted to pool prevalence data and calculate overall rates.Subgroup analysis was performed by gender, study design, country, and BP control cut-offs(140/90 and 130/80).

Results: Among the 1949 retrieved studies, 20 studies assessing 27956 individuals were included. The proportion of BP control regardless of cut-off points was 36.8% (95% CI=29.1%45.3%)based on the studies reported for both genders.The prevalence was 53.2% (95% CI=36.1%-69.6%) and 43.5% (95% CI=20.0%-70.3%) based on the studies reported just for women ormen, respectively.

Conclusion: Our findings indicate that BP control targets are not successfully achieved in hypertensive diabetic patients in the Eastern Mediterranean region. It is recommended to placegreater emphasis on the quality of hypertension care in the management of type 2 diabetes.

背景:控制血压(BP)是糖尿病患者面临的一项挑战,而且与糖尿病的不良后果有关。在本系统综述和荟萃分析中,我们调查了东地中海地区(EMR)国家高血压糖尿病患者的血压控制率:我们系统检索了截至 2023 年 1 月的 PubMed、Scopus、Embase、Cochrane 和 Web of Science 数据库中有关所有东地中海地区国家高血压糖尿病患者血压控制情况的观察性研究。我们纳入了报告血压得到控制的高血压 2 型糖尿病患者比例的研究,定义为收缩压/舒张压 < 140/90 或结果:在检索到的 1949 项研究中,有 20 项研究对 27956 人进行了评估。无论截断点如何,血压得到控制的男女比例均为 36.8%(95% CI=29.1%-45.3%),其中女性和男性的比例分别为 53.2%(95% CI=36.1%-69.6%)和 43.5%(95% CI=20.0%-70.3%)。以 130/80 和 140/90 mmHg 为目标值,估计血压控制率分别为 38.2% (95%CI 24.5, 54.1) 和 36.5% (95%CI 27.1, 47.0):我们的研究结果表明,东地中海地区的高血压糖尿病患者并未成功实现血压控制目标。建议在 2 型糖尿病管理中更加重视高血压护理的质量。
{"title":"Blood Pressure Control Among Diabetic Patients in the Eastern Mediterranean Region: A Systematic Review and Meta-Analysis","authors":"Amir Hossein Behnoush, Sepehr Khosravi, Fateme Ziamanesh, Rasha Atlasi, Ali Sheidaei, Negin Sanadgol, Amirmohammad Khalaji, Ozra Tabatabaei-Malazy, Afshin Ostovar","doi":"10.2174/0115733998327293240729080250","DOIUrl":"10.2174/0115733998327293240729080250","url":null,"abstract":"<p><strong>Background: </strong>The control of blood pressure (BP) is a challenge in diabetic patients\u0000and is associated with adverse outcomes of diabetes. In this systematic review and metaanalysis, we investigated the BP control rate among hypertensive diabetic patients in the Eastern\u0000Mediterranean Region (EMR) countries.</p><p><strong>Methods: </strong>We systematically searched PubMed, Scopus, Embase, Cochrane, and Web of Science databases up to January 2023 for observational studies on BP control among hypertensive\u0000diabetic patients in all EMR countries. We included studies reporting the proportion of hypertensive, type 2 diabetic patients with controlled BP, defined as systolic/diastolic BP < 140/90 or\u0000<130/80 mmHg. Study quality was assessed using modified STROBE guidelines, and a random-effect meta-analysis was conducted to pool prevalence data and calculate overall rates.\u0000Subgroup analysis was performed by gender, study design, country, and BP control cut-offs\u0000(140/90 and 130/80).</p><p><strong>Results: </strong>Among the 1949 retrieved studies, 20 studies assessing 27956 individuals were included. The proportion of BP control regardless of cut-off points was 36.8% (95% CI=29.1%45.3%)\u0000based on the studies reported for both genders.The prevalence was 53.2% (95% CI=36.1%-\u000069.6%) and 43.5% (95% CI=20.0%-70.3%) based on the studies reported just for women or\u0000men, respectively.</p><p><strong>Conclusion: </strong>Our findings indicate that BP control targets are not successfully achieved in hypertensive diabetic patients in the Eastern Mediterranean region. It is recommended to place\u0000greater emphasis on the quality of hypertension care in the management of type 2 diabetes.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diabetic Heart Disease: An Intricate Interplay of a Widespread Metabolic Disorder with the Cardiovascular System. 糖尿病性心脏病:广泛存在的代谢紊乱与心血管系统之间错综复杂的相互作用。
IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-07-11 DOI: 10.2174/0115733998305019240702095537
A S Kamakshi Shriya, Vaishnavi B Pawar, Acsah Annie Paul

Diabetes is a chronic medical condition that causes high glycaemic levels, leading to damage to vital organs over time. It is a common disease worldwide, affecting around 422 million individuals living in middle- and low-income countries, which make up most of the population. Unfortunately, diabetes results in 1.5 million deaths annually. Diabetic patients are at a higher risk for developing cardiovascular conditions. Diabetic heart disease constitutes multiple genres, including diabetic cardiomyopathy, coronary artery disease, and heart failure. Hypoglycaemic agents aim to prevent these metabolic issues however some of these are cardiotoxic in nature. In contrast, other hypoglycaemic agents work beyond controlling glycaemic levels with their cardioprotective properties. Given that there is an alarming increase in diabetic heart disease cases universally, we have attempted to review the existing data on the topic and the effects of hypoglycaemic drugs on heart diseases.

糖尿病是一种慢性疾病,会导致高血糖,久而久之会对重要器官造成损害。它是一种世界性的常见疾病,影响着约 4.22 亿生活在中等收入和低收入国家的人,这些国家的人口占总人口的大多数。不幸的是,糖尿病每年导致 150 万人死亡。糖尿病患者罹患心血管疾病的风险较高。糖尿病心脏病有多种类型,包括糖尿病心肌病、冠状动脉疾病和心力衰竭。降糖药物旨在预防这些代谢问题,但其中一些具有心脏毒性。与此相反,其他降糖药物除了控制血糖水平外,还具有保护心脏的作用。鉴于糖尿病心脏病病例在全球范围内呈惊人的增长趋势,我们试图回顾有关这一主题的现有数据以及降糖药物对心脏病的影响。
{"title":"Diabetic Heart Disease: An Intricate Interplay of a Widespread Metabolic Disorder with the Cardiovascular System.","authors":"A S Kamakshi Shriya, Vaishnavi B Pawar, Acsah Annie Paul","doi":"10.2174/0115733998305019240702095537","DOIUrl":"https://doi.org/10.2174/0115733998305019240702095537","url":null,"abstract":"<p><p>Diabetes is a chronic medical condition that causes high glycaemic levels, leading to damage to vital organs over time. It is a common disease worldwide, affecting around 422 million individuals living in middle- and low-income countries, which make up most of the population. Unfortunately, diabetes results in 1.5 million deaths annually. Diabetic patients are at a higher risk for developing cardiovascular conditions. Diabetic heart disease constitutes multiple genres, including diabetic cardiomyopathy, coronary artery disease, and heart failure. Hypoglycaemic agents aim to prevent these metabolic issues however some of these are cardiotoxic in nature. In contrast, other hypoglycaemic agents work beyond controlling glycaemic levels with their cardioprotective properties. Given that there is an alarming increase in diabetic heart disease cases universally, we have attempted to review the existing data on the topic and the effects of hypoglycaemic drugs on heart diseases.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141589844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of SGLT2 Inhibitors on Renal Function in Type 2 Diabetic Patients with Coronary Artery Disease Undergoing Percutaneous Intervention: A Systematic Review and Meta-Analysis. SGLT2抑制剂对接受经皮介入治疗的2型糖尿病冠心病患者肾功能的影响:系统回顾与元分析》。
IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-07-03 DOI: 10.2174/0115733998301228240625065230
Roopa Satyanarayan Basutkar, Rasheal Maria Cutinha, Varshini Sathish, Aboobacker Shahil, Najad Saneen Ck

Background and objectives: Contrast agents directly cause kidney toxicity in patients undergoing Percutaneous Intervention for cardiovascular disease with Type 2 diabetes. This meta-analysis aims to evaluate the effects of SGLT2-i on renal function in individuals undergoing Percutaneous Intervention.

Methods: The databases used for the search included PubMed, Scopus, Cochrane Central Registry of Controlled Trials, and Google Scholar. We considered Randomized controlled trials and observational studies published from January 2013 to August 2023. The eligibility to include the studies was assessed independently. The Cochrane modified data extraction form, and Joanna Briggs Institute was used. The Cochrane risk of bias tool and Newcastle-Ottawa quality assessment scale were used to assess the quality of the studies. The certainty of the evidence was assessed using GradePro software.

Results: The pooled estimate showed a substantial reduction in serum creatinine levels at 48- and 72-hours post-PCI who received SGLT2i (MD -9.57; 95% CI -18.36, -0.78; p-value 0.03) and (MD -14.40; 95% CI -28.57, -0.22; p-value 0.05). There was a decrease in the incidence of the CI-AKI among SGT2i users (RR: 0.46; 95% CI: 0.32, 0.67; p value< 0.0001). There was no significant difference in the number of patients requiring hemodialysis, but a smaller number of patients required hemodialysis among the SGLT2i users (RR: 0.88; 95% CI: 0.19, 4.07; p-value = 0.87).

Conclusions: The use of SGLT2i confers substantial beneficial effects on kidney function and reduction of incidence of Contrast-induced acute kidney injury among patients undergoing PCI procedures for cardiovascular disease with diabetes.

背景和目的:造影剂会直接导致接受经皮介入治疗的 2 型糖尿病心血管疾病患者的肾脏毒性。本荟萃分析旨在评估 SGLT2-i 对经皮介入治疗患者肾功能的影响:用于检索的数据库包括 PubMed、Scopus、Cochrane Central Registry of Controlled Trials 和 Google Scholar。我们考虑了 2013 年 1 月至 2023 年 8 月期间发表的随机对照试验和观察性研究。我们对纳入研究的资格进行了独立评估。我们使用了 Cochrane 修改过的数据提取表和乔安娜-布里格斯研究所(Joanna Briggs Institute)的数据提取表。评估研究质量时使用了 Cochrane 偏倚风险工具和纽卡斯尔-渥太华质量评估量表。使用 GradePro 软件评估证据的确定性:汇总估算结果显示,PCI 术后 48 小时和 72 小时接受 SGLT2i 治疗的患者血清肌酐水平大幅下降(MD -9.57;95% CI -18.36,-0.78;P 值 0.03)和(MD -14.40;95% CI -28.57,-0.22;P 值 0.05)。SGT2i使用者的CI-AKI发生率有所下降(RR:0.46;95% CI:0.32,0.67;P值< 0.0001)。需要血液透析的患者人数没有明显差异,但SGLT2i使用者中需要血液透析的患者人数较少(RR:0.88;95% CI:0.19,4.07;P值=0.87):结论:使用SGLT2i对心血管疾病合并糖尿病的PCI患者的肾功能有很大的益处,并能降低Contrast诱导的急性肾损伤的发生率。
{"title":"Impact of SGLT2 Inhibitors on Renal Function in Type 2 Diabetic Patients with Coronary Artery Disease Undergoing Percutaneous Intervention: A Systematic Review and Meta-Analysis.","authors":"Roopa Satyanarayan Basutkar, Rasheal Maria Cutinha, Varshini Sathish, Aboobacker Shahil, Najad Saneen Ck","doi":"10.2174/0115733998301228240625065230","DOIUrl":"https://doi.org/10.2174/0115733998301228240625065230","url":null,"abstract":"<p><strong>Background and objectives: </strong>Contrast agents directly cause kidney toxicity in patients undergoing Percutaneous Intervention for cardiovascular disease with Type 2 diabetes. This meta-analysis aims to evaluate the effects of SGLT2-i on renal function in individuals undergoing Percutaneous Intervention.</p><p><strong>Methods: </strong>The databases used for the search included PubMed, Scopus, Cochrane Central Registry of Controlled Trials, and Google Scholar. We considered Randomized controlled trials and observational studies published from January 2013 to August 2023. The eligibility to include the studies was assessed independently. The Cochrane modified data extraction form, and Joanna Briggs Institute was used. The Cochrane risk of bias tool and Newcastle-Ottawa quality assessment scale were used to assess the quality of the studies. The certainty of the evidence was assessed using GradePro software.</p><p><strong>Results: </strong>The pooled estimate showed a substantial reduction in serum creatinine levels at 48- and 72-hours post-PCI who received SGLT2i (MD -9.57; 95% CI -18.36, -0.78; p-value 0.03) and (MD -14.40; 95% CI -28.57, -0.22; p-value 0.05). There was a decrease in the incidence of the CI-AKI among SGT2i users (RR: 0.46; 95% CI: 0.32, 0.67; p value< 0.0001). There was no significant difference in the number of patients requiring hemodialysis, but a smaller number of patients required hemodialysis among the SGLT2i users (RR: 0.88; 95% CI: 0.19, 4.07; p-value = 0.87).</p><p><strong>Conclusions: </strong>The use of SGLT2i confers substantial beneficial effects on kidney function and reduction of incidence of Contrast-induced acute kidney injury among patients undergoing PCI procedures for cardiovascular disease with diabetes.</p>","PeriodicalId":10825,"journal":{"name":"Current diabetes reviews","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141497370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Current diabetes reviews
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1