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Diving Deep into Deep Learning: An Update on Artificial Intelligence in Retina. 深度学习:视网膜人工智能的最新进展。
IF 0.9 Q4 OPHTHALMOLOGY Pub Date : 2020-09-01 Epub Date: 2020-06-07 DOI: 10.1007/s40135-020-00240-2
Brian E Goldhagen, Hasenin Al-Khersan

Purpose of review: In the present article, we will provide an understanding and review of artificial intelligence in the subspecialty of retina and its potential applications within the specialty.

Recent findings: Given the significant use of diagnostic imaging within retina, this subspecialty is a fitting area for the incorporation of artificial intelligence. Researchers have aimed at creating models to assist in the diagnosis and management of retinal disease as well as in the prediction of disease course and treatment response. Most of this work thus far has focused on diabetic retinopathy, age-related macular degeneration, and retinopathy of prematurity, although other retinal diseases have started to be explored as well.

Summary: Artificial intelligence is well-suited to transform the practice of ophthalmology. A basic understanding of the technology is important for its effective implementation and growth.

综述目的:在本文中,我们将对人工智能在视网膜亚专业及其在该专业的潜在应用进行了解和综述。最近的发现:鉴于视网膜诊断成像的重要应用,这一亚专业是人工智能结合的合适领域。研究人员的目标是创建模型,以协助视网膜疾病的诊断和管理,以及在疾病进程和治疗反应的预测。尽管其他视网膜疾病也已开始探索,但迄今为止,大部分工作集中在糖尿病视网膜病变、年龄相关性黄斑变性和早产儿视网膜病变上。摘要:人工智能非常适合改变眼科的实践。对该技术的基本理解对于其有效实现和发展非常重要。
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引用次数: 7
Retinal Tamponades: Current Uses and Future Technologies. 视网膜填塞:当前用途和未来技术。
IF 0.9 Q4 OPHTHALMOLOGY Pub Date : 2020-09-01 Epub Date: 2020-07-04 DOI: 10.1007/s40135-020-00247-9
Avnish Deobhakta, Richard Rosen

Purpose of review: In this article, the current use and limitations of existing retinal tamponades are discussed. Potential novel developments that address those limitations are subsequently highlighted, along with areas of future improvements.

Recent findings: While retinal tamponades have existed for decades and improved the treatment of retinal detachments, many problems still exist with their use, including inadequate tamponade of the inferior retina, toxicity from retained heavy liquids, glaucoma, and keratopathy, among others. New advancements in the components of heavy liquids and vitreous substitutes aim to mitigate those issues.

Summary: Existing retinal tamponades, including perflurocarbon heavy liquids, fluorinated gases, and silicone oil, have specific limitations that cause potentially avoidable morbidity. New developments, such as heavy silicone oil, novel vitreous gels, and future avenues of approach, such as potentially reabsorbing heavy liquids may help increase our ability to treat retinal detachments with fewer complications.

综述目的:本文对现有视网膜填塞的应用现状及局限性进行了综述。随后强调了解决这些限制的潜在新发展,以及未来改进的领域。最近发现:虽然视网膜填塞已经存在了几十年,并改善了视网膜脱离的治疗,但其使用仍然存在许多问题,包括下视网膜填塞不足,残留重液体的毒性,青光眼和角膜病变等。重液体成分和玻璃体替代品的新进展旨在缓解这些问题。摘要:现有的视网膜填塞物,包括全氟碳重液、氟化气体和硅油,具有特定的局限性,可能导致可避免的发病率。新的发展,如重质硅油,新型玻璃体凝胶,以及未来的方法,如潜在的重吸收液体,可能有助于提高我们治疗视网膜脱离的能力,减少并发症。
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引用次数: 8
Optical Coherence Tomography: Critical Tool to Manage Expectations after Cataract Extraction. 光学相干断层扫描:管理白内障摘除后期望的关键工具。
IF 0.9 Q4 OPHTHALMOLOGY Pub Date : 2020-09-01 Epub Date: 2020-06-06 DOI: 10.1007/s40135-020-00243-z
Raquel Goldhardt, Bradley Simon Rosen

Purpose of review: To review evidence on the utility of spectral domain optical coherence tomography (SD-OCT) in evaluating retinal structure prior cataract surgery and highlight new technologies that can assess retinal function perioperatively.

Findings: SD-OCT detected clinically unsuspected macular pathology in 4.6-25% of individuals in the pre-operative cataract evaluation. The most common findings were epiretinal membrane and macular degeneration with frequencies that varied by population studied. These conditions have been associated with complication after surgery (e.g. macular edema, visual dissatisfaction). As such, findings on SD-OCT may impact the informed consent process, alter IOL selection, and provide realistic postoperative vision expectations. Other technologies that assess retinal function, such as microperimetry and multifocal ERG are beginning to be studied but their utility in the pre-operative cataract evaluation is not yet known.

Summary: SD-OCT should be incorporated as a routine test prior to surgery to manage patient expectations and assist with optimal IOL selection, as even individuals with a seemingly normal clinical exam may have macular pathology. SD-OCT is the most established method for evaluating retinal anatomy and offers the benefits of a reduction in cases with missed macular pathology and fewer postoperative visual surprises.

综述目的:回顾光谱域光学相干断层扫描(SD-OCT)在白内障手术前评估视网膜结构方面的应用证据,并强调可以评估围手术期视网膜功能的新技术。结果:SD-OCT在术前白内障评估中发现临床未怀疑的黄斑病变的比例为4.6-25%。最常见的发现是视网膜前膜和黄斑变性,其频率因研究人群而异。这些情况与术后并发症(如黄斑水肿、视力不满意)有关。因此,SD-OCT的发现可能会影响知情同意过程,改变人工晶状体的选择,并提供现实的术后视力预期。其他评估视网膜功能的技术,如显微视野测量和多焦点ERG技术正在开始研究,但它们在白内障术前评估中的应用尚不清楚。总结:SD-OCT应作为手术前的常规检查,以管理患者的期望并协助最佳IOL的选择,因为即使是看似正常的临床检查的个体也可能有黄斑病变。SD-OCT是评估视网膜解剖最成熟的方法,它提供了减少黄斑病理遗漏病例和减少术后视觉意外的好处。
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引用次数: 6
Topical Steroids in Management of Dry Eye Disease 局部类固醇治疗干眼症
IF 0.9 Q4 OPHTHALMOLOGY Pub Date : 2020-08-29 DOI: 10.1007/s40135-020-00249-7
Hayley Favre, S. Lahoti, Nasser G. Issa, Daniel A. Johnson, A. Kheirkhah
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引用次数: 1
Modern principles of the diabetic macular edema management 糖尿病性黄斑水肿的现代治疗原则
IF 0.9 Q4 OPHTHALMOLOGY Pub Date : 2020-08-24 DOI: 10.17816/OV33036
N. K. Mazurina, G. Stolyarenko
Diabetes mellitus and diabetic retinal lesions are a global challenge for healthcare systems and one of the leading causes of severe vision loss among the working age population. Retinal laser coagulation remained the standard of therapy and the only possible treatment for diabetic macular edema (DME) in the 80-90s of the last century. The introduction of anti-VEGF therapy and glucocorticoids into the wide practice has significantly expanded the range of possibilities of DME treatment, allowing not only to stabilize patients vision, but also to improve it. The analyses of the large randomized clinical trials results are made and presented in this article, that highlight the basic principles of the contemporary DME treatment. This information is intended to help the ophthalmologist to develop the most optimal approach to treatment, considering the individual characteristics of each patient and the evidence-based efficacy and safety data of different methods.
糖尿病和糖尿病性视网膜病变是全球卫生保健系统面临的挑战,也是导致劳动年龄人口严重视力丧失的主要原因之一。在上世纪80-90年代,视网膜激光凝固仍然是糖尿病性黄斑水肿(DME)的标准治疗方法和唯一可能的治疗方法。抗vegf疗法和糖皮质激素的广泛应用大大扩展了DME治疗的可能性范围,不仅可以稳定患者的视力,还可以改善视力。本文对大型随机临床试验结果进行了分析,强调了当代二甲醚治疗的基本原则。这些信息旨在帮助眼科医生在考虑每位患者的个体特征以及不同方法的循证有效性和安全性数据的情况下,制定最优的治疗方法。
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引用次数: 0
Emerging Technologies to Solve the Key Issues in Endothelial Keratoplasty 解决角膜内皮移植术关键问题的新兴技术
IF 0.9 Q4 OPHTHALMOLOGY Pub Date : 2020-08-24 DOI: 10.1007/s40135-020-00251-z
K. Brown, G. Dusting, M. Daniell
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引用次数: 1
Bilateral lacrimal gland enlargement as a clinical manifestation of sarcoidosis 双侧泪腺肿大作为结节病的临床表现
IF 0.9 Q4 OPHTHALMOLOGY Pub Date : 2020-08-24 DOI: 10.17816/OV25854
Svetlana S. Martirosyan, Diana R. Simonyan, Ilona K. Musheghyan, Mariam A. Ghazaryan
Sarcoidosis is an inflammatory disorder of unknown etiology. The main characteristics of sarcoidosis are non-caseating granulomas which can be formed in affected organs. Eye and its adnexal tissues can also be involved. In the early stages of sarcoidosis, the clinical picture may be mild and not always specific. Although the early signs of sarcoidosis are lung associated, we present a clinical case with diffuse enlargement of the lacrimal glands as a first sign of systemic sarcoidosis. A 21-years-old woman presented to the ophthalmological center with a 2-weeks history of having swollen, painful upper eyelids. Primary eye examination revealed palpable tender masses in the locations of the lacrimal glands. Characteristic for sarcoidosis X-ray findings and blood tests demanded lacrimal gland and lung biopsy for diagnosis verification. In spite sarcoidosis of lacrimal glands is a rare condition, it has to be taken into consideration in the differential diagnosis of lacrimal gland masses.
结节病是一种病因不明的炎症性疾病。结节病的主要特征是非干酪化肉芽肿,可在受累器官形成。眼睛及其附属组织也可受累。在结节病的早期阶段,临床表现可能是温和的,并不总是特异性的。虽然结节病的早期症状与肺有关,但我们提出了一个临床病例,泪腺弥漫性肿大是系统性结节病的第一个征兆。一名21岁女性,因上眼睑肿胀疼痛2周就诊于眼科中心。眼部初诊发现泪腺部位有可触及的压痛肿块。结节病的特点,x线表现和血液检查要求泪腺和肺活检确诊。虽然泪腺结节病是一种罕见的疾病,但在泪腺肿块的鉴别诊断中必须考虑到它。
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引用次数: 0
Intrastromal descemet membrane transplantation in eyes with advanced keratoconus 晚期圆锥角膜的角膜间真皮膜移植
IF 0.9 Q4 OPHTHALMOLOGY Pub Date : 2020-08-24 DOI: 10.17816/OV20425
O. Oganesyan, Оганесян Оганес Георгиевич, V. Getadaryan, Гетадарян Востан Рафаелович, P. M. Ashikova, Ашикова Патимат Магомедрасуловна, P. Makarov, Макаров Павел Васильевич, A. Khandzhyan, Ханджян Ануш Тиграновна
Background. To report the outcomes of intrastromal Descemet membrane (DM) transplantation in corneas with advanced keratoconus. Materials and methods. Three eyes of 3 patients presented with advanced, progressive keratoconus. None of the eyes had prior UV-crosslinking or any other ocular surgery performed. All eyes had a donor DM implanted into a mid-stromal pocket under local anesthesia, and clinical outcomes were evaluated at 12 months after surgery. Results. To the best of our knowledge, this is the first report of DM transplantation performed in cases of advanced keratoconus. At 12 months after surgery, the DM graft was well positioned and barely visible within the recipient stroma, and all corneas were clear. None of the eyes showed signs of keratoconus progression throughout the follow-up period. No significant changes were observed in uncorrected (UCVA) and best contact lens corrected visual acuity (BCLCVA), central endothelial cell density (ECD), corneal thinnest point (CTP) pachymetry, and maximum keratometry values (SimK and Kmax). No early or late postoperative complications were observed. Conclusions. Intrastromal DM transplantation may potentially be an alternative to intrastromal Bowman layer transplantation in eyes with advanced keratoconus, to postpone deep anterior lamellar or penetrating keratoplasty.
背景。目的:报道晚期圆锥角膜角膜间充膜(DM)移植的疗效。材料和方法。3例患者3眼表现为进展性晚期圆锥角膜。这些眼睛之前都没有进行过紫外线交联或任何其他眼部手术。所有眼均在局部麻醉下将供体DM植入间质中囊,术后12个月评估临床结果。结果。据我们所知,这是首例晚期圆锥角膜DM移植的报道。术后12个月,DM移植物定位良好,在受体间质内几乎看不见,所有角膜都清晰。在整个随访期间,没有眼睛显示圆锥角膜进展的迹象。未矫正视力(UCVA)和最佳隐形眼镜矫正视力(BCLCVA)、中心内皮细胞密度(ECD)、角膜最薄点(CTP)厚度测量和最大角膜测量值(SimK和Kmax)均无显著变化。术后未见早期或晚期并发症。结论。对于晚期圆锥角膜患者,DM间质内移植可能是一种替代角膜间质鲍曼层移植的方法,以推迟深前板层或穿透性角膜移植。
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引用次数: 0
Complex clinical case of optic neuropathy differential diagnosis 复杂视神经病变临床病例鉴别诊断
IF 0.9 Q4 OPHTHALMOLOGY Pub Date : 2020-08-24 DOI: 10.17816/OV19146
N. A. Sakhovskaya, M. Frolov, K. Kazakova, E. Belyaeva
The outcome of any damage or disease of the optic nerve is the atrophy of the optic nerve, which causes the irreversible loss of vision. The reasons of damage of the optic nerve are polymorphous, and early diagnosis allows to improve the efficacy of treatment and prevent irreversible consequences. The article presents a difficult clinical case of optic neuropathy differential diagnosis.
视神经的任何损伤或疾病的结果是视神经萎缩,导致视力的不可逆转的丧失。视神经损伤的原因是多种多样的,早期诊断可以提高治疗效果,防止不可逆转的后果。本文报告一例视神经病变的临床鉴别诊断困难。
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引用次数: 0
Conditions for improving the effectiveness of surgical treatment of patients with chronic dacryocystitis in endonasal endoscopic procedures 提高鼻内窥镜下慢性泪囊炎手术治疗效果的条件
IF 0.9 Q4 OPHTHALMOLOGY Pub Date : 2020-08-24 DOI: 10.17816/OV33437
D. Davydov, Давыдов Дмитрий Викторович, Мagomed М. Маgomedov, Магомедов Магомед Маллаевич, Napisat М. Маgomedova, Магомедова Написат Магомедовна
Introduction. Surgical treatment of patients with chronic dacryocystitis is a complex interdisciplinary problem. Lacrimal sac can be reached externally and internally (endonasally). The effectiveness of the treatment largely depends on the results of complete diagnosis and choice of a treatment method. Purpose. To analyze the effectiveness of surgical treatment of patients with chronic dacryocystitis in endonasal access. Materials and methods. The study of 225 patients consisted in the analysis of two groups of patients (20152019) with chronic dacryocystitis: the first group (110 patients) underwent an endonasal endoscopic dacryocystorhinostomy in the form of monooperation, the second underwent endonasal endoscopic dacryocystorhinostomy with additional intranasal interventions (115 patients). All patients underwent endoscopic examination of the nasal cavity and midface multispiral computed tomography (MSCT). Results. The results of the obtained data convincingly showed a higher efficiency of treatment in the group of patients with combined operations with the pathological processes revealed in intranasal localization in comparison with the group of monoperations. Conclusion. According to the study data, patients with chronic dacryocystitis should undergo full ophthalmologic and endonasal diagnostics, including multispiral computed tomography-dacryocystorhinography of the middle facial zone according to the described algorithm. When detecting pathological processes hindering the standard endonasal endoscopic dacryocystorhinostomy, it is necessary to perform an expanded scope of surgical interventions which will contribute to the efficiency of treatment of patients with chronic dacryocystitis up to 91.3%.
介绍。慢性泪囊炎的手术治疗是一个复杂的跨学科问题。泪囊可从外部和内部(经鼻)到达。治疗的有效性在很大程度上取决于完全诊断的结果和治疗方法的选择。目的。目的:分析鼻内通道慢性泪囊炎的手术治疗效果。材料和方法。225例慢性泪囊炎患者的研究包括两组(2015 - 2019)患者的分析:第一组(110例)以单手术的形式接受鼻内窥镜下泪囊鼻腔造口术,第二组(115例)接受鼻内窥镜下泪囊鼻腔造口术并进行鼻内干预。所有患者均行鼻腔内镜检查和中面部多螺旋计算机断层扫描(MSCT)。结果。所获得的数据令人信服地表明,与单手术组相比,鼻内定位病理过程显示的联合手术组的治疗效率更高。结论。根据研究资料,慢性泪囊炎患者应进行全面的眼科和鼻内诊断,包括根据所描述的算法进行面部中部区域的多螺旋计算机断层扫描-泪囊造影。当发现妨碍标准鼻内窥镜泪囊鼻腔造口术的病理过程时,有必要扩大手术干预范围,使慢性泪囊炎患者的治疗效率达到91.3%。
{"title":"Conditions for improving the effectiveness of surgical treatment of patients with chronic dacryocystitis in endonasal endoscopic procedures","authors":"D. Davydov, Давыдов Дмитрий Викторович, Мagomed М. Маgomedov, Магомедов Магомед Маллаевич, Napisat М. Маgomedova, Магомедова Написат Магомедовна","doi":"10.17816/OV33437","DOIUrl":"https://doi.org/10.17816/OV33437","url":null,"abstract":"Introduction. Surgical treatment of patients with chronic dacryocystitis is a complex interdisciplinary problem. Lacrimal sac can be reached externally and internally (endonasally). The effectiveness of the treatment largely depends on the results of complete diagnosis and choice of a treatment method. \u0000Purpose. To analyze the effectiveness of surgical treatment of patients with chronic dacryocystitis in endonasal access. \u0000Materials and methods. The study of 225 patients consisted in the analysis of two groups of patients (20152019) with chronic dacryocystitis: the first group (110 patients) underwent an endonasal endoscopic dacryocystorhinostomy in the form of monooperation, the second underwent endonasal endoscopic dacryocystorhinostomy with additional intranasal interventions (115 patients). All patients underwent endoscopic examination of the nasal cavity and midface multispiral computed tomography (MSCT). \u0000Results. The results of the obtained data convincingly showed a higher efficiency of treatment in the group of patients with combined operations with the pathological processes revealed in intranasal localization in comparison with the group of monoperations. \u0000Conclusion. According to the study data, patients with chronic dacryocystitis should undergo full ophthalmologic and endonasal diagnostics, including multispiral computed tomography-dacryocystorhinography of the middle facial zone according to the described algorithm. When detecting pathological processes hindering the standard endonasal endoscopic dacryocystorhinostomy, it is necessary to perform an expanded scope of surgical interventions which will contribute to the efficiency of treatment of patients with chronic dacryocystitis up to 91.3%.","PeriodicalId":10836,"journal":{"name":"Current Ophthalmology Reports","volume":"35 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2020-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89801875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Current Ophthalmology Reports
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