Pub Date : 2022-12-01DOI: 10.1007/s40135-022-00305-4
Benjamin R Lin, Jonathan F Russell, Hasenin Al-Khersan, Raquel Goldhardt
{"title":"A systematic review of acute zonal occult outer retinopathy with a focus on attempted treatment modalities.","authors":"Benjamin R Lin, Jonathan F Russell, Hasenin Al-Khersan, Raquel Goldhardt","doi":"10.1007/s40135-022-00305-4","DOIUrl":"10.1007/s40135-022-00305-4","url":null,"abstract":"","PeriodicalId":10836,"journal":{"name":"Current Ophthalmology Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9236774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01Epub Date: 2022-11-10DOI: 10.1007/s40135-022-00302-7
Binh Cao, Vishnu Teja Gonugunta, Naveen Radhakrishnan, Prajna Lalitha, Bharat Gurnani, Kirandeep Kaur, Geetha Iyer, Shweta Agarwal, Bhaskar Srinivasan, Jeremy D Keenan, N Venkatesh Prajna
Background: Pythium keratitis is a difficult-to-treat corneal infection.
Methods: A meta-analysis of individual patient data from observational studies of Pythium keratitis was performed. The outcomes of interest were therapeutic penetrating keratoplasty (TPK) and globe removal (evisceration, enucleation, or exenteration); the main exposures were linezolid and azithromycin use.
Findings: Of 46 eligible articles, individual patient data were available for 306 eyes (34 studies). Pythium keratitis was associated with high rates of TPK (80%, 95%CI 70-87%) and globe removal (25%, 95%CI 13-43). In multivariable models adjusting for age and country, fewer TPKs were performed in patients treated with azithromycin (RR=0.80, 95%CI 0.67-0.96; P=0.04) and linezolid (RR=0.82, 95%CI 0.67-0.99; P=0.02).
Conclusions: Studies of Pythium keratitis reported high rates of TPK and globe removal. Use of azithromycin and linezolid was associated with a lower rate of TPK. While promising, these results should be interpreted with caution given the biases inherent to observational studies.
{"title":"Outcomes of Pythium keratitis: a meta-analysis of individual patient data.","authors":"Binh Cao, Vishnu Teja Gonugunta, Naveen Radhakrishnan, Prajna Lalitha, Bharat Gurnani, Kirandeep Kaur, Geetha Iyer, Shweta Agarwal, Bhaskar Srinivasan, Jeremy D Keenan, N Venkatesh Prajna","doi":"10.1007/s40135-022-00302-7","DOIUrl":"10.1007/s40135-022-00302-7","url":null,"abstract":"<p><strong>Background: </strong>Pythium keratitis is a difficult-to-treat corneal infection.</p><p><strong>Methods: </strong>A meta-analysis of individual patient data from observational studies of Pythium keratitis was performed. The outcomes of interest were therapeutic penetrating keratoplasty (TPK) and globe removal (evisceration, enucleation, or exenteration); the main exposures were linezolid and azithromycin use.</p><p><strong>Findings: </strong>Of 46 eligible articles, individual patient data were available for 306 eyes (34 studies). Pythium keratitis was associated with high rates of TPK (80%, 95%CI 70-87%) and globe removal (25%, 95%CI 13-43). In multivariable models adjusting for age and country, fewer TPKs were performed in patients treated with azithromycin (RR=0.80, 95%CI 0.67-0.96; <i>P</i>=0.04) and linezolid (RR=0.82, 95%CI 0.67-0.99; <i>P</i>=0.02).</p><p><strong>Conclusions: </strong>Studies of Pythium keratitis reported high rates of TPK and globe removal. Use of azithromycin and linezolid was associated with a lower rate of TPK. While promising, these results should be interpreted with caution given the biases inherent to observational studies.</p>","PeriodicalId":10836,"journal":{"name":"Current Ophthalmology Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10211475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9553049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01Epub Date: 2022-10-20DOI: 10.1007/s40135-022-00295-3
Ethan S Lindgren, Onur Cil, Alan S Verkman, Neel D Pasricha
Purpose of review: To review the role of ocular surface epithelial (corneal and conjunctival) ion transporters in the pathogenesis and treatment of dry eye disease (DED).
Recent findings: Currently, anti-inflammatory agents are the mainstay of DED treatment, though there are several agents in development that target ion transport proteins on the ocular surface, acting by pro-secretory or anti-absorptive mechanisms to increase the tear fluid Film volume. Activation or inhibition of selected ion transporters can alter tear fluid osmolality, driving water transport onto the ocular surface via osmosis. Several ion transporters have been proposed as potential therapeutic targets for DED, including the cystic fibrosis transmembrane conductance regulator (CFTR), calcium-activated chloride channels (CaCCs), and the epithelial sodium channel (ENaC).
Summary: Ocular surface epithelial cell ion transporters are promising targets for pro-secretory and anti-absorptive therapies of DED.
{"title":"Ocular Surface Ion Transport and Dry Eye Disease.","authors":"Ethan S Lindgren, Onur Cil, Alan S Verkman, Neel D Pasricha","doi":"10.1007/s40135-022-00295-3","DOIUrl":"10.1007/s40135-022-00295-3","url":null,"abstract":"<p><strong>Purpose of review: </strong>To review the role of ocular surface epithelial (corneal and conjunctival) ion transporters in the pathogenesis and treatment of dry eye disease (DED).</p><p><strong>Recent findings: </strong>Currently, anti-inflammatory agents are the mainstay of DED treatment, though there are several agents in development that target ion transport proteins on the ocular surface, acting by pro-secretory or anti-absorptive mechanisms to increase the tear fluid Film volume. Activation or inhibition of selected ion transporters can alter tear fluid osmolality, driving water transport onto the ocular surface via osmosis. Several ion transporters have been proposed as potential therapeutic targets for DED, including the cystic fibrosis transmembrane conductance regulator (CFTR), calcium-activated chloride channels (CaCCs), and the epithelial sodium channel (ENaC).</p><p><strong>Summary: </strong>Ocular surface epithelial cell ion transporters are promising targets for pro-secretory and anti-absorptive therapies of DED.</p>","PeriodicalId":10836,"journal":{"name":"Current Ophthalmology Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10783585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49646151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-28DOI: 10.1007/s40135-022-00306-3
Gabriel A Quesada, K. Waltz, Rodrigo A Quesada, León Colindres, Eduardo Alas, Amarilis Portillo, Rafael Perez-Varela, Pablo Ortiz
{"title":"Update on the Light-Adjustable Lens (LAL)","authors":"Gabriel A Quesada, K. Waltz, Rodrigo A Quesada, León Colindres, Eduardo Alas, Amarilis Portillo, Rafael Perez-Varela, Pablo Ortiz","doi":"10.1007/s40135-022-00306-3","DOIUrl":"https://doi.org/10.1007/s40135-022-00306-3","url":null,"abstract":"","PeriodicalId":10836,"journal":{"name":"Current Ophthalmology Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47476708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-25DOI: 10.1007/s40135-022-00304-5
Paula A. Sepulveda-Beltran, H. Levine, A. Gibbons, A. Maharaj, Daniel S Choi, Jaime D. Martinez, Z. Corrêa, G. Amescua, J. Harbour
{"title":"Post-Radiation Cataract Management: Outcomes in Individuals with Uveal Melanoma","authors":"Paula A. Sepulveda-Beltran, H. Levine, A. Gibbons, A. Maharaj, Daniel S Choi, Jaime D. Martinez, Z. Corrêa, G. Amescua, J. Harbour","doi":"10.1007/s40135-022-00304-5","DOIUrl":"https://doi.org/10.1007/s40135-022-00304-5","url":null,"abstract":"","PeriodicalId":10836,"journal":{"name":"Current Ophthalmology Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43031406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-11DOI: 10.1007/s40135-022-00300-9
Nicole Duncan, Priyanka Sood, Sumitra S. Khandelwal
{"title":"Demodex Blepharitis: Its Role and Treatment in Ocular Surface Disease","authors":"Nicole Duncan, Priyanka Sood, Sumitra S. Khandelwal","doi":"10.1007/s40135-022-00300-9","DOIUrl":"https://doi.org/10.1007/s40135-022-00300-9","url":null,"abstract":"","PeriodicalId":10836,"journal":{"name":"Current Ophthalmology Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47177528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-11DOI: 10.1007/s40135-022-00303-6
A. Serrano, K. Osei, Marcela Huertas-Bello, Alfonso L. Sabater
{"title":"The Potential of Stem Cells as Treatment for Ocular Surface Diseases","authors":"A. Serrano, K. Osei, Marcela Huertas-Bello, Alfonso L. Sabater","doi":"10.1007/s40135-022-00303-6","DOIUrl":"https://doi.org/10.1007/s40135-022-00303-6","url":null,"abstract":"","PeriodicalId":10836,"journal":{"name":"Current Ophthalmology Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52779269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-05DOI: 10.1007/s40135-022-00296-2
Colton McCoy, Shaivi Patel, P. Thulasi
{"title":"Update on the Management of Acanthamoeba Keratitis","authors":"Colton McCoy, Shaivi Patel, P. Thulasi","doi":"10.1007/s40135-022-00296-2","DOIUrl":"https://doi.org/10.1007/s40135-022-00296-2","url":null,"abstract":"","PeriodicalId":10836,"journal":{"name":"Current Ophthalmology Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42541686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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