首页 > 最新文献

Current Ophthalmology Reports最新文献

英文 中文
Phakic Lenses in Corneal Ectasia 角膜扩张中的晶状体
IF 0.9 Q4 OPHTHALMOLOGY Pub Date : 2023-05-09 DOI: 10.1007/s40135-023-00309-8
C. Barraquer-Coll
{"title":"Phakic Lenses in Corneal Ectasia","authors":"C. Barraquer-Coll","doi":"10.1007/s40135-023-00309-8","DOIUrl":"https://doi.org/10.1007/s40135-023-00309-8","url":null,"abstract":"","PeriodicalId":10836,"journal":{"name":"Current Ophthalmology Reports","volume":"1 1","pages":"1-7"},"PeriodicalIF":0.9,"publicationDate":"2023-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47424657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Update on Immune Checkpoint Inhibitor-Associated Uveitis 免疫检查点抑制剂相关性葡萄膜炎研究进展
IF 0.9 Q4 OPHTHALMOLOGY Pub Date : 2023-05-02 DOI: 10.1007/s40135-023-00312-z
Christian Kim, Samantha Paul, Jose J. Echegaray
{"title":"Update on Immune Checkpoint Inhibitor-Associated Uveitis","authors":"Christian Kim, Samantha Paul, Jose J. Echegaray","doi":"10.1007/s40135-023-00312-z","DOIUrl":"https://doi.org/10.1007/s40135-023-00312-z","url":null,"abstract":"","PeriodicalId":10836,"journal":{"name":"Current Ophthalmology Reports","volume":"1 1","pages":"1-11"},"PeriodicalIF":0.9,"publicationDate":"2023-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49618474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Approach to Astigmatism Correction during Cataract Surgery 白内障手术中矫正散光的方法
IF 0.9 Q4 OPHTHALMOLOGY Pub Date : 2023-04-14 DOI: 10.1007/s40135-023-00310-1
J. Varas
{"title":"Approach to Astigmatism Correction during Cataract Surgery","authors":"J. Varas","doi":"10.1007/s40135-023-00310-1","DOIUrl":"https://doi.org/10.1007/s40135-023-00310-1","url":null,"abstract":"","PeriodicalId":10836,"journal":{"name":"Current Ophthalmology Reports","volume":"1 1","pages":"1-6"},"PeriodicalIF":0.9,"publicationDate":"2023-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43709791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison and comparability of pneumotonometry and rebound tonometry results with Maklakov’s applanation tonometry 气测和回弹测压与Maklakov平压测压结果的比较与可比性
IF 0.9 Q4 OPHTHALMOLOGY Pub Date : 2023-04-09 DOI: 10.17816/ov321245
D. Belov, N. G. Zumbulidze, Amina I. Yusupova, F. Kasymov
BACKGROUND: Introduction and use of various tonometry methods can lead to misinterpretation of intraocular pressure results and influence the choice of treating approaches by ophthalmologist in a glaucoma patient. AIM: To compare pneumotonometry and rebound tonometry results with Maklakovs applanation tonometry and to develop corrections for their comparability. MATERIALS AND METHODS: The study included 75 patients. All subjects underwent Maklakov applanation tonometry (10 g) and pachymetry (Topcon SP-3000P). In 48 patients (94 eyes) of the 1st group, pneumotonometry (TONOREF II Nidek) was performed, and 27 patients of the 2nd group (52 eyes) underwent rebound tonometry (iCare IC-100). RESULTS: The mean difference in intraocular pressure level in the 1st group was 4.81 (p 0.001), and in the 2nd 0.98 mmHg (p = 0.399). Both methods pneumo- and rebound tonometry showed underestimated results with intraocular pressure less than 23.0 and 22.5 mmHg (respectively) relative to applanation tonometry and, conversely, overestimated intraocular pressure when these values were exceeded. A significant (p 0.001) strong (R2 = 0.86) relationship between applanation and rebound tonometry was obtained, which made it possible, using regression analysis, to develop a formula for recalculating results of iCare tonometry into those of Maklakov tonometry: PMaklakov = 0.40 PiCare + 13.44. CONCLUSIONS: Both pneumo- and rebound tonometry demonstrate adequate results of P0 with intraocular pressure below 23.0 and 22.5 mmHg (respectively) and overestimate the results when these values are exceeded. The developed formula allows converting the results of iCare tonometry into the values of the Maklakovs tonometry.
背景:在青光眼患者中,引入和使用各种眼压测量方法会导致眼压结果的误解,并影响眼科医生对治疗方法的选择。目的:比较气测和回弹血压计与Maklakovs平压血压计的结果,并对其可比性进行修正。材料与方法:纳入75例患者。所有受试者均行Maklakov眼压测压仪(10 g)和测厚仪(Topcon SP-3000P)。第一组48例(94眼)行TONOREF II Nidek测气仪,第二组27例(52眼)行iCare IC-100测眼压仪。结果:第一组眼压水平平均差值为4.81 (p 0.001),第二组眼压水平平均差值为0.98 mmHg (p = 0.399)。当眼压分别低于23.0 mmHg和22.5 mmHg时,这两种方法的眼压测量结果都被低估,相反,当眼压超过这些值时,眼压被高估。平压性和回弹性血压计之间存在显著(p 0.001)强(R2 = 0.86)的相关性,这使得通过回归分析,可以建立一个将iCare血压计结果重新计算为Maklakov血压计结果的公式:PMaklakov = 0.40 PiCare + 13.44。结论:当眼压分别低于23.0 mmHg和22.5 mmHg时,肺测压和回弹测压均显示P0的结果是适当的,而当眼压超过这些值时,结果会高估。所开发的公式允许将iCare血压计的结果转换为maklakov血压计的值。
{"title":"Comparison and comparability of pneumotonometry and rebound tonometry results with Maklakov’s applanation tonometry","authors":"D. Belov, N. G. Zumbulidze, Amina I. Yusupova, F. Kasymov","doi":"10.17816/ov321245","DOIUrl":"https://doi.org/10.17816/ov321245","url":null,"abstract":"BACKGROUND: Introduction and use of various tonometry methods can lead to misinterpretation of intraocular pressure results and influence the choice of treating approaches by ophthalmologist in a glaucoma patient. \u0000AIM: To compare pneumotonometry and rebound tonometry results with Maklakovs applanation tonometry and to develop corrections for their comparability. \u0000MATERIALS AND METHODS: The study included 75 patients. All subjects underwent Maklakov applanation tonometry (10 g) and pachymetry (Topcon SP-3000P). In 48 patients (94 eyes) of the 1st group, pneumotonometry (TONOREF II Nidek) was performed, and 27 patients of the 2nd group (52 eyes) underwent rebound tonometry (iCare IC-100). \u0000RESULTS: The mean difference in intraocular pressure level in the 1st group was 4.81 (p 0.001), and in the 2nd 0.98 mmHg (p = 0.399). Both methods pneumo- and rebound tonometry showed underestimated results with intraocular pressure less than 23.0 and 22.5 mmHg (respectively) relative to applanation tonometry and, conversely, overestimated intraocular pressure when these values were exceeded. A significant (p 0.001) strong (R2 = 0.86) relationship between applanation and rebound tonometry was obtained, which made it possible, using regression analysis, to develop a formula for recalculating results of iCare tonometry into those of Maklakov tonometry: PMaklakov = 0.40 PiCare + 13.44. \u0000CONCLUSIONS: Both pneumo- and rebound tonometry demonstrate adequate results of P0 with intraocular pressure below 23.0 and 22.5 mmHg (respectively) and overestimate the results when these values are exceeded. The developed formula allows converting the results of iCare tonometry into the values of the Maklakovs tonometry.","PeriodicalId":10836,"journal":{"name":"Current Ophthalmology Reports","volume":"19 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79417706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A giant foreign body of the orbit. A clinical case 轨道上一个巨大的外来物体。1例临床病例
IF 0.9 Q4 OPHTHALMOLOGY Pub Date : 2023-04-09 DOI: 10.17816/ov109283
I. Filatova
The article describes a casuistic case of a long asymptomatic stay of a giant foreign body in the orbit and of its removal. Immediately after the injury and at primary surgical treatment, the foreign body was not diagnosed. The patient did not have any complaints for a long time, then gradually there was a periodic double vision when looking straight ahead, a dense formation under the eyebrow began to be revealed by palpation. The foreign body was successfully removed almost a year after the injury.
本文描述了一个长期无症状停留在轨道上的巨大异物及其移除的诡辩案例。在受伤后和初步手术治疗时,异物未被诊断。患者长期无主诉,后逐渐出现周期性复视,直视前方时开始触诊出眉下致密物。在受伤近一年后,异物被成功移除。
{"title":"A giant foreign body of the orbit. A clinical case","authors":"I. Filatova","doi":"10.17816/ov109283","DOIUrl":"https://doi.org/10.17816/ov109283","url":null,"abstract":"The article describes a casuistic case of a long asymptomatic stay of a giant foreign body in the orbit and of its removal. Immediately after the injury and at primary surgical treatment, the foreign body was not diagnosed. The patient did not have any complaints for a long time, then gradually there was a periodic double vision when looking straight ahead, a dense formation under the eyebrow began to be revealed by palpation. The foreign body was successfully removed almost a year after the injury.","PeriodicalId":10836,"journal":{"name":"Current Ophthalmology Reports","volume":"20 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81476514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The use of optical coherence tomography angiography in differential diagnosis of conjunctival melanocytic tumors 光学相干断层血管造影在结膜黑色素细胞瘤鉴别诊断中的应用
IF 0.9 Q4 OPHTHALMOLOGY Pub Date : 2023-04-09 DOI: 10.17816/ov173174
T. Kiseleva, S. Saakyan, V. Makukhina, K. V. Lugovkina, S. Milash, N. F. Musova, Andrey A. Zharov
BACKGROUND: Optical coherence tomography angiography (OCTA) is a noninvasive method of eye microcirculation evaluation. Few reports are published on the use of OCTA for anterior segment (AS) vessels analysis in healthy eyes and in conjunctival tumors, and their vascular characteristics are still not thoroughly investigated. These questions are of importance, as it is known that tumors vasculature is indicative of the patients vital prognosis. AIM: The aim of our study was to investigate the potential of AS-OCTA in evaluation of normal conjunctival vessels architecture as well as that in melanocytic neoplasms. MATERIALS AND METHODS: 20 healthy volunteers (20 eyes) and 20 patients (20 eyes) with conjunctival nevi and melanomas were examined. AS optical coherence tomography (OCT) and AS-OCTA were performed. Scan analysis included qualitative assessment (vessels pattern, lumen, tortuosity) and quantitative assessment [perfusion density (PD, %) index]. Mean (MPD), maximum (MaxPD) and perifocal PD (PPD) were determined. RESULTS: In normal group, predominantly radial pattern of the vessels was revealed, their caliber remaining the same along their entire length; larger vessels were more often discovered in deep conjunctival layers. The lowest PD value (29.9%) was registered in the inferior conjunctival segment, and the highest (36.7%) in the nasal one. In the conjunctival tumors area tortuosity of the vessels, uneven vessels caliber along their length, and increase in the PD value were observed. Melanomas were characterized by an increase in the lace-like pattern and by presence of confluent pattern zones; MaxPD value was more than 50%. Significant difference was found between MPD values of normal conjunctiva and MPD values in conjunctival melanoma. CONCLUSIONS: AS-OCTA is an informative method for the visualization of vessels in normal conjunctiva and in conjunctival tumors. If the tumors vessels are unevenly distributed, MaxPD should be measured.
背景:光学相干断层血管造影(OCTA)是一种无创的眼部微循环评估方法。在健康眼睛和结膜肿瘤中使用OCTA进行前节(AS)血管分析的报道很少,其血管特征仍未得到充分研究。这些问题是很重要的,因为我们知道肿瘤的血管系统是病人生命预后的指示。目的:我们的研究目的是探讨as - octa在评估正常结膜血管结构以及黑色素细胞肿瘤中的潜力。材料与方法:对20名健康志愿者(20只眼)和20名结膜痣、黑色素瘤患者(20只眼)进行检查。进行光学相干层析成像(OCT)和光学相干层析成像(AS- octa)。扫描分析包括定性评估(血管形态、管腔、弯曲度)和定量评估[灌注密度(PD, %)指数]。测定平均(MPD)、最大(MaxPD)和焦周PD (PPD)。结果:正常组血管呈放射状分布,直径沿全长保持不变;较大的血管多见于结膜深层。下结膜段PD值最低(29.9%),鼻段PD值最高(36.7%)。结膜肿瘤区血管扭曲,血管直径沿长度不均匀,PD值升高。黑素瘤的特征是蕾丝样模式增加和融合模式区存在;MaxPD值大于50%。正常结膜的MPD值与结膜黑色素瘤的MPD值有显著性差异。结论:AS-OCTA是正常结膜和结膜肿瘤血管可视化的一种信息丰富的方法。如果肿瘤血管分布不均匀,应测量MaxPD。
{"title":"The use of optical coherence tomography angiography in differential diagnosis of conjunctival melanocytic tumors","authors":"T. Kiseleva, S. Saakyan, V. Makukhina, K. V. Lugovkina, S. Milash, N. F. Musova, Andrey A. Zharov","doi":"10.17816/ov173174","DOIUrl":"https://doi.org/10.17816/ov173174","url":null,"abstract":"BACKGROUND: Optical coherence tomography angiography (OCTA) is a noninvasive method of eye microcirculation evaluation. Few reports are published on the use of OCTA for anterior segment (AS) vessels analysis in healthy eyes and in conjunctival tumors, and their vascular characteristics are still not thoroughly investigated. These questions are of importance, as it is known that tumors vasculature is indicative of the patients vital prognosis. \u0000AIM: The aim of our study was to investigate the potential of AS-OCTA in evaluation of normal conjunctival vessels architecture as well as that in melanocytic neoplasms. \u0000MATERIALS AND METHODS: 20 healthy volunteers (20 eyes) and 20 patients (20 eyes) with conjunctival nevi and melanomas were examined. AS optical coherence tomography (OCT) and AS-OCTA were performed. Scan analysis included qualitative assessment (vessels pattern, lumen, tortuosity) and quantitative assessment [perfusion density (PD, %) index]. Mean (MPD), maximum (MaxPD) and perifocal PD (PPD) were determined. \u0000RESULTS: In normal group, predominantly radial pattern of the vessels was revealed, their caliber remaining the same along their entire length; larger vessels were more often discovered in deep conjunctival layers. The lowest PD value (29.9%) was registered in the inferior conjunctival segment, and the highest (36.7%) in the nasal one. In the conjunctival tumors area tortuosity of the vessels, uneven vessels caliber along their length, and increase in the PD value were observed. Melanomas were characterized by an increase in the lace-like pattern and by presence of confluent pattern zones; MaxPD value was more than 50%. Significant difference was found between MPD values of normal conjunctiva and MPD values in conjunctival melanoma. \u0000CONCLUSIONS: AS-OCTA is an informative method for the visualization of vessels in normal conjunctiva and in conjunctival tumors. If the tumors vessels are unevenly distributed, MaxPD should be measured.","PeriodicalId":10836,"journal":{"name":"Current Ophthalmology Reports","volume":"28 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73846899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The options of an individual approach to the modification of sinustrabeculectomy for hypotensive effect prolongation 为延长降压效果而修改鼻窦管切除术的个体化入路的选择
IF 0.9 Q4 OPHTHALMOLOGY Pub Date : 2023-04-09 DOI: 10.17816/ov256670
Elena A. Suleiman, S. Petrov
BACKGROUND: Reducing scarring in the postoperative period is one of the main tasks of glaucoma surgery. AIM: To develop new modifications of sinustrabeculectomy in the surgical treatment of primary open-angle glaucoma normalizing and prolonging the outflow of aqueous humor along newly formed pathways. MATERIALS AND METHODS: Surgical procedures were performed in 106 patients (109 eyes) with primary open-angle glaucoma of moderate and advanced stages, without any history of previous surgeries. Patients were divided into groups: 1a 25 patients (25 eyes) who underwent sinustrabeculectomy with the formation of grooves for the intramuscular fluid outflow, 1b 26 patients (28 eyes) who underwent of sinustrabeculectomy with scleral flap twisting, 1c 28 patients(29 eyes) who underwent sinustrabeculectomy with scleral flap stitching, and the control group 27 patients (27 eyes) who underwent routine sinustrabeculectomy. The follow-up duration was up to 24 months. RESULTS: In 1 month after surgery, the average level of intramuscular pressure was comparable and remained low in all groups. Complete compensation of intramuscular pressure in groups 1a, 1b and 1c was observed in 80%, 75% and 76% of cases; partial in 16%, 18% and 21% of cases; failure in 4%, 7% and 3% of cases, respectively. In the control group (2), complete hypotensive success was noted in 55% of cases; partial in 30% of cases; failure in 15% of cases. CONCLUSIONS: Developed new methods of sinustrabeculectomy allow to obtain a prolonged hypotensive effect.
背景:减少术后瘢痕形成是青光眼手术的主要任务之一。目的:探讨鼻窦小梁切除术治疗原发性开角型青光眼的新方法,使房水沿新形成的通道流出正常化并延长流出时间。材料与方法:106例(109只眼)中晚期原发性开角型青光眼,既往无手术史。患者分为:1a组25例(25眼)行鼻窦炎切除并形成肌内液流出沟,1b组26例(28眼)行巩膜瓣扭转鼻窦炎切除术,1c组28例(29眼)行巩膜瓣缝合鼻窦炎切除术,对照组27例(27眼)行常规鼻窦炎切除术。随访时间长达24个月。结果:术后1个月,各组平均肌内压力水平相当且保持在较低水平。在1a、1b和1c组,80%、75%和76%的病例出现肌内压力完全代偿;部分占16%,18%和21%;失败率分别为4%、7%和3%。在对照组(2),55%的病例完全降压成功;30%的病例部分发病;15%的病例失败。结论:发展了新的鼻窦切除术方法,可以获得长期的降压效果。
{"title":"The options of an individual approach to the modification of sinustrabeculectomy for hypotensive effect prolongation","authors":"Elena A. Suleiman, S. Petrov","doi":"10.17816/ov256670","DOIUrl":"https://doi.org/10.17816/ov256670","url":null,"abstract":"BACKGROUND: Reducing scarring in the postoperative period is one of the main tasks of glaucoma surgery. \u0000AIM: To develop new modifications of sinustrabeculectomy in the surgical treatment of primary open-angle glaucoma normalizing and prolonging the outflow of aqueous humor along newly formed pathways. \u0000MATERIALS AND METHODS: Surgical procedures were performed in 106 patients (109 eyes) with primary open-angle glaucoma of moderate and advanced stages, without any history of previous surgeries. Patients were divided into groups: 1a 25 patients (25 eyes) who underwent sinustrabeculectomy with the formation of grooves for the intramuscular fluid outflow, 1b 26 patients (28 eyes) who underwent of sinustrabeculectomy with scleral flap twisting, 1c 28 patients(29 eyes) who underwent sinustrabeculectomy with scleral flap stitching, and the control group 27 patients (27 eyes) who underwent routine sinustrabeculectomy. The follow-up duration was up to 24 months. \u0000RESULTS: In 1 month after surgery, the average level of intramuscular pressure was comparable and remained low in all groups. Complete compensation of intramuscular pressure in groups 1a, 1b and 1c was observed in 80%, 75% and 76% of cases; partial in 16%, 18% and 21% of cases; failure in 4%, 7% and 3% of cases, respectively. In the control group (2), complete hypotensive success was noted in 55% of cases; partial in 30% of cases; failure in 15% of cases. \u0000CONCLUSIONS: Developed new methods of sinustrabeculectomy allow to obtain a prolonged hypotensive effect.","PeriodicalId":10836,"journal":{"name":"Current Ophthalmology Reports","volume":"205 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77460105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical methods of retinal pigment epithelium transplantation in rabbits in experiment 实验兔视网膜色素上皮移植的手术方法
IF 0.9 Q4 OPHTHALMOLOGY Pub Date : 2023-04-09 DOI: 10.17816/ov237101
N. V. Neroeva, M. Lagarkova, P. A. Ilyukhin, N. S. Izmailova, O. A. Utkina, P. Laktionov, V. Chernonosova, Anatoly E. Kharitonov
The article is devoted to the study of surgical methods of retinal pigment epithelium transplantation in experiment on rabbits. The history of retinal pigment epithelium transplantation is briefly characterized in the study. Characteristics of the methods used are presented, their limitations, possibilities, and requirements for implementation in practice are highlighted. The results of transplantation of suspension of retinal pigment epithelium cells differentiated from human induced pluripotent stem cells (IPSC-RPE) without and with the use of platelet-rich blood plasma (PRP) are also considered. According to the results of the analysis we have developed modified methods of IPSC-RPE cells transplantation in the experiment on rabbits, which allow to reduce the number of postoperative complications, which provides the best therapeutic effect. Prospects for further studies are associated with a comparative analysis of the proposed techniques in terms of cell survival at different terms, anatomical integration and functional efficiency in the dynamics.
本文研究了兔视网膜色素上皮移植的手术方法。本研究简要介绍了视网膜色素上皮移植的历史。介绍了所使用的方法的特点,强调了它们的局限性、可能性和在实践中实施的要求。我们还考虑了在不使用富血小板血浆(PRP)和使用富血小板血浆(PRP)的情况下,将人诱导多能干细胞(IPSC-RPE)分化的视网膜色素上皮细胞悬浮液移植的结果。根据分析结果,我们在家兔实验中开发了改良的IPSC-RPE细胞移植方法,减少了术后并发症的发生,提供了最佳的治疗效果。进一步研究的前景与所提出的技术在不同条件下的细胞存活、解剖学整合和动力学中的功能效率方面的比较分析有关。
{"title":"Surgical methods of retinal pigment epithelium transplantation in rabbits in experiment","authors":"N. V. Neroeva, M. Lagarkova, P. A. Ilyukhin, N. S. Izmailova, O. A. Utkina, P. Laktionov, V. Chernonosova, Anatoly E. Kharitonov","doi":"10.17816/ov237101","DOIUrl":"https://doi.org/10.17816/ov237101","url":null,"abstract":"The article is devoted to the study of surgical methods of retinal pigment epithelium transplantation in experiment on rabbits. The history of retinal pigment epithelium transplantation is briefly characterized in the study. Characteristics of the methods used are presented, their limitations, possibilities, and requirements for implementation in practice are highlighted. The results of transplantation of suspension of retinal pigment epithelium cells differentiated from human induced pluripotent stem cells (IPSC-RPE) without and with the use of platelet-rich blood plasma (PRP) are also considered. According to the results of the analysis we have developed modified methods of IPSC-RPE cells transplantation in the experiment on rabbits, which allow to reduce the number of postoperative complications, which provides the best therapeutic effect. Prospects for further studies are associated with a comparative analysis of the proposed techniques in terms of cell survival at different terms, anatomical integration and functional efficiency in the dynamics.","PeriodicalId":10836,"journal":{"name":"Current Ophthalmology Reports","volume":"56 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76921401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A clinical case of multifocal chorioretinitis associated with Herpes zoster 带状疱疹合并多灶性脉络膜视网膜炎1例
IF 0.9 Q4 OPHTHALMOLOGY Pub Date : 2023-04-09 DOI: 10.17816/ov108827
Svetlana S. Martirosyan, Ofelya B. Ginoyan, A. Hovakimyan, Diana R. Simonyan, Ilona K. Musheghyan
The Varicella-Zoster virus (VZV) is the etiologic agent of one of the most common infectious diseases among children, chickenpox. In its recurrent form it may cause a far more devastating disease, Herpes zoster. The disease can be manifested as conjunctivitis, episcleritis, scleritis, keratitis, anterior uveitis. Chorioretinal lesions may occur in patients with immunosuppression. A 14-year-old male patient has been admitted to the Ophthalmologic center after S.V. Malayan with complaints of visual decrease, redness and pains. In the history of the patient the transferred chickenpox was marked a few months ago. By biomicroscopic and fundoscopic examination conjunctival hyperemia, corneal precipitates, severe inflammatory reaction in the anterior chamber, sectoral iris atrophy, posterior synechiae, yellow-white multifocal, peripheral lesions on the fundus of both eyes and pigmented macular scar in the right eye were found out. Laboratory tests showed high levels of anti-VZV IgG. Treatment was prescribed in the form of local instillations and subtenon injections, as well as antiviral tablets. As a result of treatment, remission of inflammatory process and improvement of visual acuity were registered. The specific characteristic of present case study is the description of single clinical manifestations of Herpes zoster, which are necessary to detect for correct and timely treatment.
水痘带状疱疹病毒(VZV)是儿童中最常见的传染病之一水痘的病原体。它的复发形式可能导致一种更具破坏性的疾病,带状疱疹。该病可表现为结膜炎、巩膜炎、巩膜炎、角膜炎、葡萄膜前炎。免疫抑制患者可发生绒毛膜视网膜病变。一名14岁男性患者在S.V. Malayan后因视力下降、红肿和疼痛而入住眼科中心。在病人的病史中,几个月前发现了转移的水痘。通过生物显微镜及眼底镜检查,发现结膜充血、角膜沉淀、前房严重炎症反应、部门性虹膜萎缩、后粘连、黄白色多灶、双眼眼底外周病变及右眼黄斑色素瘢痕。实验室检测显示抗vzv IgG水平高。治疗的形式是局部滴注和subtenon注射,以及抗病毒药片。治疗后,炎症过程缓解,视力改善。本病例研究的具体特点是描述了带状疱疹的单一临床表现,需要及时发现并正确治疗。
{"title":"A clinical case of multifocal chorioretinitis associated with Herpes zoster","authors":"Svetlana S. Martirosyan, Ofelya B. Ginoyan, A. Hovakimyan, Diana R. Simonyan, Ilona K. Musheghyan","doi":"10.17816/ov108827","DOIUrl":"https://doi.org/10.17816/ov108827","url":null,"abstract":"The Varicella-Zoster virus (VZV) is the etiologic agent of one of the most common infectious diseases among children, chickenpox. In its recurrent form it may cause a far more devastating disease, Herpes zoster. The disease can be manifested as conjunctivitis, episcleritis, scleritis, keratitis, anterior uveitis. Chorioretinal lesions may occur in patients with immunosuppression. \u0000A 14-year-old male patient has been admitted to the Ophthalmologic center after S.V. Malayan with complaints of visual decrease, redness and pains. In the history of the patient the transferred chickenpox was marked a few months ago. By biomicroscopic and fundoscopic examination conjunctival hyperemia, corneal precipitates, severe inflammatory reaction in the anterior chamber, sectoral iris atrophy, posterior synechiae, yellow-white multifocal, peripheral lesions on the fundus of both eyes and pigmented macular scar in the right eye were found out. Laboratory tests showed high levels of anti-VZV IgG. Treatment was prescribed in the form of local instillations and subtenon injections, as well as antiviral tablets. As a result of treatment, remission of inflammatory process and improvement of visual acuity were registered. The specific characteristic of present case study is the description of single clinical manifestations of Herpes zoster, which are necessary to detect for correct and timely treatment.","PeriodicalId":10836,"journal":{"name":"Current Ophthalmology Reports","volume":"1 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79028054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Features of differential diagnosis of direct carotid-cavernous fistula. Clinical case 直接颈动脉-海绵窦瘘的鉴别诊断特点。临床病例
IF 0.9 Q4 OPHTHALMOLOGY Pub Date : 2023-04-09 DOI: 10.17816/ov112530
T. V. Tabashnikova, N. K. Serova, S. Yakovlev
Traumatic brain injury can cause various pathological conditions both in the eyeball and in the cranial cavity. The presented clinical case demonstrates the features of differential diagnosis of direct carotid-cavernous fistula and secondary post-traumatic glaucoma. Direct carotid-cavernous fistula is the formation of a communication between the internal carotid artery and the cavernous sinus and the discharge of arterial blood into it. The first symptom of a carotid-cavernous fistula is a pulsating noise in the head and above the eye. The manifest signs in the clinical picture are the signs of obstruction of venous outflow from the eye and the orbit: proptosis, eyelid edema and chemosis, congestive redness of the eye, varicose subcutaneous veins of the eyelids, as well as dilated ophthalmic vein visualized by ultrasound of the orbit, ophthalmic hypertension, oculomotor disorders, state of the fundus. The clinical picture in patients with secondary post-traumatic contusion glaucoma, in addition to an increase in intraocular pressure, is characterized by the presence of a congestive redness of the eye, changes in the cornea from mild superficial opacities to more dense ones, luxation or subluxation of the lens into the anterior chamber or vitreous, destruction of the vitreous or intraocular hemorrhage. The similarity of clinical manifestations of traumatic carotid-cavernous fistula and secondary post-traumatic glaucoma can cause difficulties in differential diagnosis.
创伤性脑损伤可引起眼球和颅腔内的各种病理状况。本病例具有直接颈动脉-海绵窦瘘与继发性创伤后青光眼的鉴别诊断特点。直接颈内动脉-海绵窦瘘是颈内动脉与海绵窦之间形成的通道,并将动脉血排出其中。颈动脉海绵状瘘管的第一个症状是头部和眼睛上方有搏动的噪音。临床表现为眼球及眼眶静脉流出受阻的征象:眼球突出、眼睑水肿及化脓、充血红肿、眼睑皮下静脉曲张、眼眶超声显示眼静脉扩张、眼压增高、动眼力障碍、眼底状况。继发性创伤后挫伤青光眼患者的临床表现除了眼压升高外,还表现为眼睛充血发红,角膜从轻度浅表性混浊变为更致密的混浊,晶状体脱位或半脱位进入前房或玻璃体,玻璃体破坏或眼内出血。外伤性颈动脉海绵窦瘘与继发性外伤性青光眼临床表现相似,给鉴别诊断带来困难。
{"title":"Features of differential diagnosis of direct carotid-cavernous fistula. Clinical case","authors":"T. V. Tabashnikova, N. K. Serova, S. Yakovlev","doi":"10.17816/ov112530","DOIUrl":"https://doi.org/10.17816/ov112530","url":null,"abstract":"Traumatic brain injury can cause various pathological conditions both in the eyeball and in the cranial cavity. The presented clinical case demonstrates the features of differential diagnosis of direct carotid-cavernous fistula and secondary post-traumatic glaucoma. Direct carotid-cavernous fistula is the formation of a communication between the internal carotid artery and the cavernous sinus and the discharge of arterial blood into it. The first symptom of a carotid-cavernous fistula is a pulsating noise in the head and above the eye. The manifest signs in the clinical picture are the signs of obstruction of venous outflow from the eye and the orbit: proptosis, eyelid edema and chemosis, congestive redness of the eye, varicose subcutaneous veins of the eyelids, as well as dilated ophthalmic vein visualized by ultrasound of the orbit, ophthalmic hypertension, oculomotor disorders, state of the fundus. The clinical picture in patients with secondary post-traumatic contusion glaucoma, in addition to an increase in intraocular pressure, is characterized by the presence of a congestive redness of the eye, changes in the cornea from mild superficial opacities to more dense ones, luxation or subluxation of the lens into the anterior chamber or vitreous, destruction of the vitreous or intraocular hemorrhage. The similarity of clinical manifestations of traumatic carotid-cavernous fistula and secondary post-traumatic glaucoma can cause difficulties in differential diagnosis.","PeriodicalId":10836,"journal":{"name":"Current Ophthalmology Reports","volume":"1 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78592066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Current Ophthalmology Reports
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1