Current Opinion in Critical Care最新文献

Purpose of review: To summarize the clinical evidence on nutritional support for critically ill patients, the (patho)physiological mechanisms involved, and areas of future research.

Recent findings: Large randomized controlled trials have shown that early nutrition induces dose-dependent harm in critically ill patients, regardless of the feeding route, and that early high-dose amino acids are harmful. Harm has been attributed to feeding-induced suppression of cellular repair pathways including autophagy and ketogenesis, to aggravation of hyperglycemia and insulin needs, and to increased urea cycle activity. Additionally, acute critical illness was shown to be a state of anabolic resistance. The absence of benefit of early enhanced nutritional support on short- and long-term outcomes was observed in all studied subgroups.

Summary: While early high-dose nutrition should be avoided in all critically ill patients, the optimal initiation time of nutrition support for the individual patient, as well as ideal composition and dosing of nutrition over time remain unclear. Future studies should elucidate how fasting-induced repair pathways can be activated while avoiding prolonged starvation, and how hyperglycemia and high insulin need could be prevented. Potential strategies include intermittent fasting, ketogenic diets, ketone supplements, and alternative glucose-lowering agents, whether or not in combination with exercise.

Purpose of review: To explore recent insights into measures of time-burden insults in intracranial pressure (ICP) monitoring, and potential implications for clinical management.

Recent findings: The ICP is an important therapeutic target in patients with traumatic brain injury (TBI) and some other brain injuries. Current clinical guidelines in TBI recommend starting treatment above a fixed ICP threshold of 22 mmHg. The concept of ICP burden was introduced recently, which takes both intensity and duration of an episode of elevated ICP into account. This burden of ICP is visualized in a colour-coded plot. In different cohorts of brain injured patients, prolonged ICP elevations, even at values below 20 or 22 mmHg, are associated with worse outcomes, and higher ICPs can only be tolerated briefly. The ICP burden plots are influenced by age, cerebral perfusion pressure, and cerebrovascular autoregulation, illustrating the complexity and dynamic aspect of secondary insults of elevated ICP events, and the need for personalization. Two clinical trials are currently investigating the impact of presenting this information at the bedside to clinicians.

Summary: The implementation of information on ICP burden at the patient's bedside could assist clinicians in recognizing secondary brain injury and result in more personalized ICP management.

Purpose of review: Acute liver failure (ALF) is a rare, life-threatening but potentially reversible clinical syndrome characterized by multiple organ failure secondary to the rapid loss of liver function. Key management challenges include severe cerebral oedema and complex treatments to support multiple organ failure. This review focuses on the fundamental principles of management and recent treatment advances.

Recent findings: Identifying the cause of ALF is key to guiding specific therapies. The early commencement of continuous renal replacement therapy (CRRT) to control hyperammonaemia can now be considered an important standard of care, and plasma exchange may have a role in the sickest of ALF patients; however, other blood purification modalities still lack supporting evidence. Close monitoring, regular investigations, careful attention to neuroprotective measures, as well as optimizing general physiological supports is essential. Where possible, patients should be transferred to a liver transplant centre to achieve the best chance of transplant-free survival, or to undergo emergency liver transplantation if required.

Summary: This review outlines current principles of ALF management, emerging treatment strategies, and a practical approach to management in the ICU. These recommendations can form the development of local guidelines, incorporating current best evidence for managing this rare but often lethal condition.

Purpose of review: This review highlights brain-gut neuroimmune interactions in the context of critical illness. Neural regulation of inflammation, gut innervation, and the brain-gut axis in critical illness are discussed.

Recent findings: Recent studies indicate that the brain-gut axis and the enteric nervous system are integral to the regulation of local and systemic inflammation. Experimental evidence suggests that neural reflexes control immune responses, and specific neural signals promote gastrointestinal homeostasis. The understanding of these interactions in the clinical context remains limited, necessitating further investigation. Notably, therapeutic interventions targeting neuro-immune pathways have shown promise in preclinical models, suggesting that a better understanding of the neuro-immune crosstalk in the critically ill may potentially identify novel therapeutic targets.

Summary: Critical illness involves complex organ dysfunction, not least in the gastrointestinal system. A multitude of neuroimmune interactions between the intestinal wall, immune cells, peripheral nerves and the central nervous system regulate inflammation. While experimental evidence supports the role of neural reflexes in controlling immune responses, clinical validation is lacking in the context of critical care. Future research needs to explore whether specific neural signals or mechanisms of neuro-immune crosstalk can be harnessed to restore and support gastrointestinal homeostasis in the critically ill.

Purpose of review: Neuroprognostication after acute brain injury (ABI) is complex. In this review, we examine the threats to accurate neuroprognostication, discuss strategies to mitigate the self-fulfilling prophecy, and how to approach the indeterminate prognosis.

Recent findings: The goal of neuroprognostication is to provide a timely and accurate prediction of a patient's neurologic outcome so treatment can proceed in accordance with a patient's values and preferences. Neuroprognostication should be delayed until at least 72 h after injury and/or only when the necessary prognostic data is available to avoid early withdraw life-sustaining treatment on patients who may otherwise survive with a good outcome. Clinicians should be aware of the limitations of available predictors and prognostic models, the role of flawed heuristics and the self-fulfilling prophecy, and the influence of surrogate decision-maker bias on end-of-life decisions.

Summary: The approach to neuroprognostication after ABI should be systematic, use highly reliable multimodal data, and involve experts to minimize the risk of erroneous prediction and perpetuating the self-fulfilling prophecy. Even when such standards are rigorously upheld, the prognosis may be indeterminate. In such cases, clinicians should engage in shared decision-making with surrogates and consider the use of a time-limited trial.

Purpose of review: To provide an overview of recent advancements in minimally invasive intra-abdominal source control techniques.

Recent findings: There have been multiple recent advances in minimally invasive techniques for managing intra-abdominal infection or sepsis. Endoscopic based interventions include stenting, suturing, clip placement, and endoscopic vacuum therapy. Robotic surgery is becoming progressively more popular in emergency general surgery and offers comparable results compared to laparoscopic surgery with lower rates of conversion to open.

Summary: Endoscopic based interventions and minimally invasive surgery offer comparable outcomes to more invasive interventions with less morbidity for patients, though the ability to perform these techniques may not be limited to tertiary and quaternary health centers. Providers must use their clinical judgment to determine the best course of action.

Purpose of review: The concept of 'time is spine' emphasizes early or ultra-early surgical decompression within 24 or 12 h, respectively, after spinal cord injury (SCI) to maximize recovery. This review updates the latest findings on the timing of surgical decompression and hemodynamic management in acute SCI, focusing on neurological outcomes and complications.

Recent findings: While early decompression may improve neurological outcomes, factors like injury severity, comorbidities, and system resources affect surgical timing. Recent studies question the benefits of ultra-early decompression, finding no significant improvement at 12 months, suggesting earlier analyses may have overstated its benefits. Current recommendations include tailoring decompression timing to individual cases, considering patient-specific and systemic factors. New techniques like spinal cord pressure monitoring, intraoperative ultrasound, and advanced imaging are advancing targeted intervention and hemodynamic management in SCI.

Summary: The timing of spinal decompression and hemodynamic management may impact neurological function, however, because of the deficiencies of current studies, individualized, patient-tailored decision-making is critical. A multidisciplinary approach that considers injury severity and patient characteristics is essential for optimal management. Further research is required to refine the timing of surgical intervention and explore additional factors influencing recovery.

Purpose of review: To review the evidence that supports the implementation of goal-directed care bundle protocols to improve outcomes from neurocritical conditions, and of the possible advantage of specific over generalized protocols.

Recent findings: Articles from January 1, 2023 to July 31, 2024 were searched to evaluate the effectiveness of standardized management in neurological emergencies. The use of care bundles and standardized protocols with time- and target-related metrics has shown benefit in patients with acute stroke and traumatic brain injury.

Summary: A goal-directed care protocol to guide standard management implemented by a multidisciplinary team can improve outcomes from neurological emergencies. However, implementation challenges need to be addressed before wide adoption of protocolized care for maximum benefit to populations.

Purpose of review: This study aims to examine the ethical and legal discourse surrounding normothermic regional perfusion (NRP) for donation after circulatory death (DCD).

Recent findings: NRP is well established within Europe but faces challenges in the US and is not utilized in a variety of other countries. NRP compliance with the dead donor rule (DDR) and Uniform Declaration of Death Act (UDDA) is the most significant recently addressed US ethical and legal issue. Additionally, NRP procedures raise concerns regarding public education, informed consent, public engagement, and trust. Inconsistent NRP regulation - such as in the US- is a cause for concern with the anticipated increase in NRP frequency in support of organ recovery and transplantation. There is no single repository for NRP technical and outcome data to support practice refinement - a key aspect given practice variation between centers and countries.

Summary: NRP-based organ recovery presents ethical and legal challenges to be addressed by organ donation and transplantation clinicians and organizations in conjunction with public representatives. Additional inquiry into the determination of donor circulatory death, family information needs for authorization, and coordinated regulation of NRP practice is needed to ensure that ethical and legal concerns are appropriately addressed. Public engagement is essential to bolster and preserve trust.