Н. В. Бучинская, Михаил Михайлович Костик, О. Л. Колобова, Л. Н. Мельникова
Mucopolysaccharidosis type I (MPS I) is a hereditary metabolic disease that manifests itself in childhood by systemic damage to tissues and organs, a constantly progressive course leading to disability. Diagnosis of mild forms of the disease is particularly difficult due to the absence of specific symptoms. A specific symptom of the mild forms of MPS I (as for other types of MPS) is joint stiffness in children combined with hernia, frequent infections, or valvular defects. Stiffness in MPS I is often interpreted as a manifestation of rheumatological diseases (arthrogriposis, juvenile idiopathic arthritis). The article offers a simple algorithm for diagnosing MPS I, which helps to eliminate the disease using a simple test for determining the activity of an enzyme called alpha-L-iduronidase in a dried blood spot.
粘多糖病I型(MPS I)是一种遗传性代谢性疾病，表现为儿童期组织和器官的全身性损害，其病程不断进展，最终导致残疾。由于没有特定的症状，诊断这种疾病的轻度形式特别困难。轻度型MPS I(与其他类型的MPS一样)的一个特定症状是儿童关节僵硬并伴有疝、频繁感染或瓣膜缺损。MPS I的僵硬常被解释为风湿病的表现(关节关节炎、幼年特发性关节炎)。这篇文章提供了一种简单的诊断MPS I的算法，通过一种简单的测试来确定一种叫做α - l -伊杜醛酸酶的酶在干燥血斑中的活性，这种方法有助于消除这种疾病。
{"title":"Как не пропустить мягкие формы мукополисахаридоза I типа у пациентов с суставными проявлениями заболевания","authors":"Н. В. Бучинская, Михаил Михайлович Костик, О. Л. Колобова, Л. Н. Мельникова","doi":"10.15690/vsp.v17i6.1978","DOIUrl":"https://doi.org/10.15690/vsp.v17i6.1978","url":null,"abstract":"Mucopolysaccharidosis type I (MPS I) is a hereditary metabolic disease that manifests itself in childhood by systemic damage to tissues and organs, a constantly progressive course leading to disability. Diagnosis of mild forms of the disease is particularly difficult due to the absence of specific symptoms. A specific symptom of the mild forms of MPS I (as for other types of MPS) is joint stiffness in children combined with hernia, frequent infections, or valvular defects. Stiffness in MPS I is often interpreted as a manifestation of rheumatological diseases (arthrogriposis, juvenile idiopathic arthritis). The article offers a simple algorithm for diagnosing MPS I, which helps to eliminate the disease using a simple test for determining the activity of an enzyme called alpha-L-iduronidase in a dried blood spot.","PeriodicalId":10919,"journal":{"name":"Current Paediatrics","volume":"150 1","pages":"473-479"},"PeriodicalIF":0.0,"publicationDate":"2019-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89992195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Due to the recent introduction of golimumab into paediatric rheumatology practice, an overview of the clinical studies of this tumour necrosis factor alpha inhibitor, most of which were conducted with adult patients with rheumatic diseases, has been presented. Clinical laboratory effects and tolerability of golimumab in the form of subcutaneous injections have been analysed for rheumatoid arthritis, psoriatic arthritis, and spondylitis. Evaluation of the efficacy and tolerability of golimumab in long-term observational studies (up to 5 years) has been discussed.
{"title":"Голимумаб в лечении хронических воспалительных заболеваний суставов во взрослой популяции: клиническая эффективность и переносимость","authors":"Н. В. Чичасова","doi":"10.15690/vsp.v17i6.1975","DOIUrl":"https://doi.org/10.15690/vsp.v17i6.1975","url":null,"abstract":"Due to the recent introduction of golimumab into paediatric rheumatology practice, an overview of the clinical studies of this tumour necrosis factor alpha inhibitor, most of which were conducted with adult patients with rheumatic diseases, has been presented. Clinical laboratory effects and tolerability of golimumab in the form of subcutaneous injections have been analysed for rheumatoid arthritis, psoriatic arthritis, and spondylitis. Evaluation of the efficacy and tolerability of golimumab in long-term observational studies (up to 5 years) has been discussed.","PeriodicalId":10919,"journal":{"name":"Current Paediatrics","volume":"38 1","pages":"449-457"},"PeriodicalIF":0.0,"publicationDate":"2019-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78073566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Д. С. Крючко, Ирина Ивановна Рюмина, В В Челышева, Е. В. Соколова, Е. Н. Байбарина
Infant mortality is one of the key indicators of demography, characterizing not only the state of health and a social standard of living in a country, region, city, but also an indicator of the level of state development. In recent years there has been a steady downward trend in infant mortality. To the greatest extent, this trend is driven by improved quality of medical care. However, death of children outside healthcare facilities is the least controlled in the structure of infant mortality. The article considers the main causes of deaths of children under the age of one year outside healthcare facilities in the Russian Federation in 2017, presents data of the world and national statistics, analyses possible solutions to the problem.
{"title":"Младенческая смертность вне лечебных учреждений и пути ее снижения","authors":"Д. С. Крючко, Ирина Ивановна Рюмина, В В Челышева, Е. В. Соколова, Е. Н. Байбарина","doi":"10.15690/VSP.V17I6.1973","DOIUrl":"https://doi.org/10.15690/VSP.V17I6.1973","url":null,"abstract":"Infant mortality is one of the key indicators of demography, characterizing not only the state of health and a social standard of living in a country, region, city, but also an indicator of the level of state development. In recent years there has been a steady downward trend in infant mortality. To the greatest extent, this trend is driven by improved quality of medical care. However, death of children outside healthcare facilities is the least controlled in the structure of infant mortality. The article considers the main causes of deaths of children under the age of one year outside healthcare facilities in the Russian Federation in 2017, presents data of the world and national statistics, analyses possible solutions to the problem.","PeriodicalId":10919,"journal":{"name":"Current Paediatrics","volume":"352 1","pages":"434-440"},"PeriodicalIF":0.0,"publicationDate":"2019-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82601470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The presented review of the special literature data (on MEDLINE and eLIBRARY.RU databases) makes it possible to determine a number of topical issues for preventing child disability as well as trends of scientific research in this area, taking into account the causes of disability and its structure by the underlying disease. The World Health Organization has established a relentless focus on the problem of disability, including that of children, which is reflected in the continuous improvement of methods for assessing and classifying persistent disabilities. It has been shown that the prevention of disability in children and the support of families raising handicapped children and children with disabilities are among the main priorities of the state social policy of the Russian Federation. The data on modern technologies for reducing the genetic burden in the population from the perspective of prevention of hereditary and congenital diseases, including orphan ones, has been presented. The results of studies indicating the increasing role of the intestinal microbiota in the development and prevention of a number of diseases affecting the formation of disability in children have been presented. The problem of combating antibiotic resistance is considered from a preventive perspective. A number of scientific studies is devoted to non-infectious pathology, which is becoming increasingly important in the formation of disability in children of different age groups, starting from the neonatal period. The actual data on the role of obesity in the formation of serious health disorders has been given. The opinion is expressed on the need to create a system of hygienic and medico-psychological safety of children's life in conditions of hyperinformatisation and the modern environmental situation. It is assumed that the implementation of the results of the proposed research into health care practice will make it possible to influence the processes of disability in a child on a deeper pathogenetic level as well as to improve the arrangement of preventive activities in this direction.
{"title":"О перспективах научных исследований в области профилактики детской инвалидности","authors":"Александр Александрович Баранов, Р. Н. Терлецкая","doi":"10.15690/VSP.V17I6.1972","DOIUrl":"https://doi.org/10.15690/VSP.V17I6.1972","url":null,"abstract":"The presented review of the special literature data (on MEDLINE and eLIBRARY.RU databases) makes it possible to determine a number of topical issues for preventing child disability as well as trends of scientific research in this area, taking into account the causes of disability and its structure by the underlying disease. The World Health Organization has established a relentless focus on the problem of disability, including that of children, which is reflected in the continuous improvement of methods for assessing and classifying persistent disabilities. It has been shown that the prevention of disability in children and the support of families raising handicapped children and children with disabilities are among the main priorities of the state social policy of the Russian Federation. The data on modern technologies for reducing the genetic burden in the population from the perspective of prevention of hereditary and congenital diseases, including orphan ones, has been presented. The results of studies indicating the increasing role of the intestinal microbiota in the development and prevention of a number of diseases affecting the formation of disability in children have been presented. The problem of combating antibiotic resistance is considered from a preventive perspective. A number of scientific studies is devoted to non-infectious pathology, which is becoming increasingly important in the formation of disability in children of different age groups, starting from the neonatal period. The actual data on the role of obesity in the formation of serious health disorders has been given. The opinion is expressed on the need to create a system of hygienic and medico-psychological safety of children's life in conditions of hyperinformatisation and the modern environmental situation. It is assumed that the implementation of the results of the proposed research into health care practice will make it possible to influence the processes of disability in a child on a deeper pathogenetic level as well as to improve the arrangement of preventive activities in this direction.","PeriodicalId":10919,"journal":{"name":"Current Paediatrics","volume":"54 1","pages":"426-433"},"PeriodicalIF":0.0,"publicationDate":"2019-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86377561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The paediatric patient is considered to be a child. However, when it comes to communication with a patient, his consent, implementation of appointments, then the party of interaction is supposed to be an adult. In this regard, the paediatric patient is represented by a child-adult alliance, which allows us to speak of a ‘complex patient’. At the same time, his personal agency (the ability to independently formulate a complaint, accept appointments and achieve compliance) changes with the age of a child, coming to him from an adult. This determines the efficacy of screening as well as the main tactics of interaction between the doctor and the patient, explanation, and compliance. Based on the theory of periodization of the personality development, answers are given to the questions: who, a child or an adult, formulates a complaint, who accepts the explanation and who is the subject to compliance? It has been shown that in early childhood (up to 3 years) the patient's subjectivity in the formulation of a complaint and a picture of the disease, the perception of prescriptions and adherence to compliance is provided by the parent. During the pre-school (3–7 years) and primary school (7–11 years) periods, the picture is mosaic: the doctor compares the opinion of the parent and his child to get a picture of the disease, he gives prescriptions to the parent and/or to the child, so both of them can be a subject to compliance. And only in adolescence (12–17 years) a child can be almost a completely independent subject in all aspects of interaction in the doctor-patient system.
{"title":"Пациент в педиатрии: ребенок, взрослый или оба?","authors":"В. П. Чемеков, А. В. Шашелева","doi":"10.15690/vsp.v17i5.1958","DOIUrl":"https://doi.org/10.15690/vsp.v17i5.1958","url":null,"abstract":"The paediatric patient is considered to be a child. However, when it comes to communication with a patient, his consent, implementation of appointments, then the party of interaction is supposed to be an adult. In this regard, the paediatric patient is represented by a child-adult alliance, which allows us to speak of a ‘complex patient’. At the same time, his personal agency (the ability to independently formulate a complaint, accept appointments and achieve compliance) changes with the age of a child, coming to him from an adult. This determines the efficacy of screening as well as the main tactics of interaction between the doctor and the patient, explanation, and compliance. Based on the theory of periodization of the personality development, answers are given to the questions: who, a child or an adult, formulates a complaint, who accepts the explanation and who is the subject to compliance? It has been shown that in early childhood (up to 3 years) the patient's subjectivity in the formulation of a complaint and a picture of the disease, the perception of prescriptions and adherence to compliance is provided by the parent. During the pre-school (3–7 years) and primary school (7–11 years) periods, the picture is mosaic: the doctor compares the opinion of the parent and his child to get a picture of the disease, he gives prescriptions to the parent and/or to the child, so both of them can be a subject to compliance. And only in adolescence (12–17 years) a child can be almost a completely independent subject in all aspects of interaction in the doctor-patient system.","PeriodicalId":10919,"journal":{"name":"Current Paediatrics","volume":"12 1","pages":"408-412"},"PeriodicalIF":0.0,"publicationDate":"2018-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76289759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Е. Г. Старикова, Н. И. Шубина, Ольга Владимировна Воронкова, Ю. В. Ковширина, Н Д Яровой
Background. Cryptosporidium protozoa are the leading causative agent of diarrhea and cause of death in children under 5 years of age. The role of cryptosporidia in the development and course of acute intestinal infections (AII) in children in Russia remains unstudied. Objective. Our aim was to study the prevalence and clinical laboratory features of cryptosporidium-associated aII in children under 5 years of age. Methods. A cross-sectional study (conducted in March-June 2017) included children admitted to hospital with symptoms of AII (fever, loose watery stools, weakness, decreased appetite and/or vomiting) by the ambulance service. On admission, stool samples were collected from all patients. Cryptosporidium oocysts were determined by microscopic examination of faecal smears stained according to Tsil-Nielsen after preliminary concentration by a modified formalin-ether technique. The presence of intestinal pathogens was determined by a bacteriological technique and using a polymerase chain reaction. Results. The study included 107 children with AII (girls — 51%). Cryptosporidia were detected in 28 (26%) patients, in 93% of cases — together with bacterial and/or viral pathogens. The etiological structure of cryptosporidium-associated AII and AII in cryptosporidiosis negative children (n = 79) did not differ. On admission, children with cryptosporidium-associated AII had a higher blood leukocyte count — 13.0_109/L (9.2; 16.0) versus 8.3_109/L (6.1; 11.2) in children without cryptosporidiosis (p < 0.001). It has been also found that antibiotics were more often used in the treatment of children with cryptosporidium-associated AII — in 21 (75%) versus 39 (49%) in the comparison group (p = 0.026). Conclusion. Cryptosporidia are detected in every fourth child with AII under 5 years of age. Patients with cryptosporidia are distinguished by a higher level of blood leukocytes upon admission and a more frequent prescription of antibiotics than in the group of cryptosporidiosis negative patients.
{"title":"Распространенность и клиниколабораторные особенности криптоспоридиоза у детей в возрасте до 5 лет: одномоментное исследование госпитальных случаев острой кишечной инфекции","authors":"Е. Г. Старикова, Н. И. Шубина, Ольга Владимировна Воронкова, Ю. В. Ковширина, Н Д Яровой","doi":"10.15690/VSP.V17I4.1925","DOIUrl":"https://doi.org/10.15690/VSP.V17I4.1925","url":null,"abstract":"Background. Cryptosporidium protozoa are the leading causative agent of diarrhea and cause of death in children under 5 years of age. The role of cryptosporidia in the development and course of acute intestinal infections (AII) in children in Russia remains unstudied. Objective. Our aim was to study the prevalence and clinical laboratory features of cryptosporidium-associated aII in children under 5 years of age. Methods. A cross-sectional study (conducted in March-June 2017) included children admitted to hospital with symptoms of AII (fever, loose watery stools, weakness, decreased appetite and/or vomiting) by the ambulance service. On admission, stool samples were collected from all patients. Cryptosporidium oocysts were determined by microscopic examination of faecal smears stained according to Tsil-Nielsen after preliminary concentration by a modified formalin-ether technique. The presence of intestinal pathogens was determined by a bacteriological technique and using a polymerase chain reaction. Results. The study included 107 children with AII (girls — 51%). Cryptosporidia were detected in 28 (26%) patients, in 93% of cases — together with bacterial and/or viral pathogens. The etiological structure of cryptosporidium-associated AII and AII in cryptosporidiosis negative children (n = 79) did not differ. On admission, children with cryptosporidium-associated AII had a higher blood leukocyte count — 13.0_109/L (9.2; 16.0) versus 8.3_109/L (6.1; 11.2) in children without cryptosporidiosis (p < 0.001). It has been also found that antibiotics were more often used in the treatment of children with cryptosporidium-associated AII — in 21 (75%) versus 39 (49%) in the comparison group (p = 0.026). Conclusion. Cryptosporidia are detected in every fourth child with AII under 5 years of age. Patients with cryptosporidia are distinguished by a higher level of blood leukocytes upon admission and a more frequent prescription of antibiotics than in the group of cryptosporidiosis negative patients.","PeriodicalId":10919,"journal":{"name":"Current Paediatrics","volume":"31 1","pages":"316-321"},"PeriodicalIF":0.0,"publicationDate":"2018-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82802833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The review presents an analysis of the mechanisms of iron effect on the brain development. The importance of iron deficiency in the perinatal period is considered as a risk factor for the development of neuropsychiatric disorders in children with autism spectrum disorders (ASDs). Possible causes of sideropenia are discussed; data on haematological and biochemical parameters characterizing iron metabolism in children with ASDs are presented. The demand for studying the role of iron metabolism imbalance in the development of neuropsychiatric disorders in order to clarify pathogenetic mechanisms of ASDs and to determine methods for their correction is emphasized.
{"title":"Роль железа в патогенезе расстройств аутистического спектра у детей","authors":"Ольга Васильевна Костина","doi":"10.15690/VSP.V17I4.1920","DOIUrl":"https://doi.org/10.15690/VSP.V17I4.1920","url":null,"abstract":"The review presents an analysis of the mechanisms of iron effect on the brain development. The importance of iron deficiency in the perinatal period is considered as a risk factor for the development of neuropsychiatric disorders in children with autism spectrum disorders (ASDs). Possible causes of sideropenia are discussed; data on haematological and biochemical parameters characterizing iron metabolism in children with ASDs are presented. The demand for studying the role of iron metabolism imbalance in the development of neuropsychiatric disorders in order to clarify pathogenetic mechanisms of ASDs and to determine methods for their correction is emphasized.","PeriodicalId":10919,"journal":{"name":"Current Paediatrics","volume":"47 1","pages":"281-286"},"PeriodicalIF":0.0,"publicationDate":"2018-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83758410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background. Giardiasis in children remains an urgent problem, the significance of which is determined by the endemicity for many countries and regions, outbreaks of sporadic epidemics, polymorphism of clinical symptoms, and insufficient treatment efficacy. Objective. Our aim was to study the results of giardiasis treatment using giardicidal drugs or their combination with probiotics in children. Methods. We analyzed the frequency of Giardia lamblia elimination (the main outcome) as a result of giardiasis treatment (laboratory confirmed) in children aged from 3 months to 18 years who received giardicidal drugs (nifuratel, albendazole) or their combination with probiotics based on Saccharomyces boulardii (probiotic 1) and live freeze-dried lactic acid bacteria Lactobacillus acidophilus (L. gasseri), Bifidobacterium infantis, and Enterococcus faecium (probiotic 2) in outpatient or inpatient settings. Additionally, we registered the duration of the main symptoms of giardiasis (abdominal pain, diarrhea), the prevalence of intestinal dysbiosis and lactase deficiency. The considering period is from January 2015 to September 2017. Results. The results of giardiasis treatment were studied in 4 groups: monotherapy with nifuratel (n = 65) or albendazole (n = 64), a combination of nifuratel + probiotic 1 (n = 67) or albendazole + probiotic 2 (n = 64). The groups were comparable by sex, age, and clinical manifestations of the disease. The elimination of lamblia on the 14–16th day of monotherapy with giardicidal drugs was achieved in 56–60%, when combined with probiotics — in 84% of patients for each combination (df = 3, p < 0.001). Against the background of combination therapy, the disease symptoms (abdominal pain, diarrhea, vomiting) were reversed 1.5 times faster; the number of patients with lactase deficiency and intestinal dysbiosis decreased two and more times, under monotherapy with giardicidal drugs — 1.2 times (df = 3, p < 0.001). Conclusion. Giardiasis treatment in children using combination therapy, including giardicidal drugs and probiotics, is more effective than monotherapy with giardicidal drugs.
{"title":"Результаты лечения гиардиаза у детей с применением противолямблиозных препаратов и их комбинации с пробиотиками: ретроспективное когортное исследование","authors":"О. г. Кимирилова, Г. А. Харченко","doi":"10.15690/VSP.V17I4.1923","DOIUrl":"https://doi.org/10.15690/VSP.V17I4.1923","url":null,"abstract":"Background. Giardiasis in children remains an urgent problem, the significance of which is determined by the endemicity for many countries and regions, outbreaks of sporadic epidemics, polymorphism of clinical symptoms, and insufficient treatment efficacy. Objective. Our aim was to study the results of giardiasis treatment using giardicidal drugs or their combination with probiotics in children. Methods. We analyzed the frequency of Giardia lamblia elimination (the main outcome) as a result of giardiasis treatment (laboratory confirmed) in children aged from 3 months to 18 years who received giardicidal drugs (nifuratel, albendazole) or their combination with probiotics based on Saccharomyces boulardii (probiotic 1) and live freeze-dried lactic acid bacteria Lactobacillus acidophilus (L. gasseri), Bifidobacterium infantis, and Enterococcus faecium (probiotic 2) in outpatient or inpatient settings. Additionally, we registered the duration of the main symptoms of giardiasis (abdominal pain, diarrhea), the prevalence of intestinal dysbiosis and lactase deficiency. The considering period is from January 2015 to September 2017. Results. The results of giardiasis treatment were studied in 4 groups: monotherapy with nifuratel (n = 65) or albendazole (n = 64), a combination of nifuratel + probiotic 1 (n = 67) or albendazole + probiotic 2 (n = 64). The groups were comparable by sex, age, and clinical manifestations of the disease. The elimination of lamblia on the 14–16th day of monotherapy with giardicidal drugs was achieved in 56–60%, when combined with probiotics — in 84% of patients for each combination (df = 3, p < 0.001). Against the background of combination therapy, the disease symptoms (abdominal pain, diarrhea, vomiting) were reversed 1.5 times faster; the number of patients with lactase deficiency and intestinal dysbiosis decreased two and more times, under monotherapy with giardicidal drugs — 1.2 times (df = 3, p < 0.001). Conclusion. Giardiasis treatment in children using combination therapy, including giardicidal drugs and probiotics, is more effective than monotherapy with giardicidal drugs.","PeriodicalId":10919,"journal":{"name":"Current Paediatrics","volume":"1 1","pages":"301-306"},"PeriodicalIF":0.0,"publicationDate":"2018-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78716631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
М. А. Лаврова, Ольга Александровна Львова, Людмила Валерьевна Токарская, З. С. Лазаускене
The findings of investigations published between 2000 and 2016 on the study of parental interaction with children with a risk of autism spectrum disorders (ASD) were analyzed. The article demonstrates that early parent-child interaction in such families has distinctive features and can be one of the significant factors of both the risk of ASD development in children at an early age and the compensation of their manifestations. At the same time, such characteristics of the parent-child interaction as maternal sensitivity (the ability to perceive and accurately interpret the child's attachment signals and be able to respond promptly and adequately to these signals) and synchronism (the coordination of movements, actions and other time-dependent indicators; joint attention) are not early markers of ASD development in a child. The authors noted that the issues of parent-child interaction are rarely studied, and the survey samples are limited.
{"title":"ЗНАЧЕНИЕ ДЕТСКО-РОДИТЕЛЬСКОГО ВЗАИМОДЕЙСТВИЯ КАК ФАКТОРА РИСКА АТИПИЧНОГО РАЗВИТИЯ ДЕТЕЙ С РАССТРОЙСТВАМИ АУТИСТИЧЕСКОГО СПЕКТРА","authors":"М. А. Лаврова, Ольга Александровна Львова, Людмила Валерьевна Токарская, З. С. Лазаускене","doi":"10.15690/VSP.V17I3.1887","DOIUrl":"https://doi.org/10.15690/VSP.V17I3.1887","url":null,"abstract":"The findings of investigations published between 2000 and 2016 on the study of parental interaction with children with a risk of autism spectrum disorders (ASD) were analyzed. The article demonstrates that early parent-child interaction in such families has distinctive features and can be one of the significant factors of both the risk of ASD development in children at an early age and the compensation of their manifestations. At the same time, such characteristics of the parent-child interaction as maternal sensitivity (the ability to perceive and accurately interpret the child's attachment signals and be able to respond promptly and adequately to these signals) and synchronism (the coordination of movements, actions and other time-dependent indicators; joint attention) are not early markers of ASD development in a child. The authors noted that the issues of parent-child interaction are rarely studied, and the survey samples are limited.","PeriodicalId":10919,"journal":{"name":"Current Paediatrics","volume":"42 1","pages":"194-199"},"PeriodicalIF":0.0,"publicationDate":"2018-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83481110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"МЕД ОТ КАШЛЯ","authors":"В. К. Таточенко","doi":"10.15690/vsp.v17i2.1885","DOIUrl":"https://doi.org/10.15690/vsp.v17i2.1885","url":null,"abstract":"","PeriodicalId":10919,"journal":{"name":"Current Paediatrics","volume":"1 1","pages":"170-171"},"PeriodicalIF":0.0,"publicationDate":"2018-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90119872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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