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ПЕРСПЕКТИВЫ ДЛИТЕЛЬНОГО ПРИМЕНЕНИЯ МАКРОЛИДНЫХ АНТИБИОТИКОВ ПРИ БРОНХОЭКТАЗАХ У ДЕТЕЙ: ВОПРОСЫ И ОТВЕТЫ 儿童支气管切开术持续使用罂粟抗生素的前景:问题和答案
Pub Date : 2018-05-23 DOI: 10.15690/vsp.v17i2.1884
Н. Б. Лазарева, Евгения Валерьевна Ших, Е. В. Реброва
The article discusses issues related to the long-term administration of macrolide antibiotics for a bronchoectatic disorder of the pulmonary system in children. The relevant information about the results of long-term intake of macrolides in adults and children, the effective dose titration, possible toxic effects of therapy, including the development of cardiotoxic effect and ways to prevent it, has been enlightened in detail. It has been noted that a limited number of clinical studies involving children determine the need for studying the possibility to extrapolate adult treatment.
这篇文章讨论了长期服用大环内酯类抗生素治疗儿童肺系统支气管扩张性疾病的相关问题。详细介绍了成人和儿童长期服用大环内酯类药物的结果、有效剂量滴定、治疗可能的毒性作用,包括心脏毒性作用的发展和预防方法。有人指出,涉及儿童的临床研究数量有限,因此需要研究推断成人治疗的可能性。
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引用次数: 0
ПСЕВДОПАРАЛИЧ ПАРРО ПРИ РАННЕМ ВРОЖДЕННОМ СИФИЛИСЕ: КЛИНИЧЕСКИЙ СЛУЧАЙ 帕罗早期梅毒的假性瘫痪:临床病例
Pub Date : 2018-05-23 DOI: 10.15690/vsp.v17i2.1882
И. Х. Белялетдинова, Инна Васильевна Митрофанова, Татьяна Витальевна Кириченко, Е. Н. Абрамова, Т. В. Арсеньева, М. В. Базарова, С. В. Шахгильдян
Background. Congenital syphilis is a severe intrauterine infection which, affecting most of the organs and systems of a child, can lead to his disability. However, it is extremely difficult to suspect congenital syphilis in a child in the absence of information about prior syphilis in his mother. The article presents a case of a monosymptomatic clinical picture of early congenital syphilis. Description of the Clinical Case . At the age of 1 month, the child had hyperemia, isolated edema of the right forearm, and restriction of limb movements. He was examined by a pediatrician who suspected a fracture of the forearm bones. X-ray did not show any fracture. The situation was regarded as an allergic reaction; desensitizing therapy was prescribed during which the range of movements in the right arm slightly increased. At the age of 2 months, there was a decrease in the range of movements in the left arm. On admission, the condition was regarded as moderate one. No fever; no signs of intoxication. Skin and visible mucous membranes were not changed. Cardiopulmonary activity was satisfactory. The abdomen was palpable in all compartments, painless. The liver was enlarged 6 cm, of dense consistency. The spleen was enlarged 5 cm. Bowel and bladder functions were normal. Neurological status: the reaction to examination was adequate, emotional cry. Cranial nerves without pathology. Can see and hear. Restricted range of movements in the arms; passive movements were painful. Muscle tone in the arms was low, in the legs — closer to physiological one. Equal and brisk tendon reflexes from the arms and legs. Large fontanel 1.5[1]1.5 cm, not protruded. X-ray examination of the forearm bones showed a change in the structure of the epiphyses of both forearm bones that was common to syphilitic osteochondritis. Conclusion . The article describes the complexity of diagnosis of early congenital syphilis in a child aged 2 months in the absence of a corresponding anamnesis in his mother. The need to rule out syphilitic infection in infants with motor impairments, born from unexamined mothers, has been emphasized.
背景。先天性梅毒是一种严重的宫内感染,影响儿童的大部分器官和系统,可导致其残疾。然而,在缺乏其母亲既往梅毒信息的情况下,怀疑儿童患有先天性梅毒是极其困难的。文章提出了一个单症状的早期先天性梅毒的临床图片的情况。临床病例描述。1月龄时,患儿充血,右前臂孤立性水肿,肢体活动受限。一名儿科医生对他进行了检查,怀疑他的前臂骨折。x线未见骨折。这种情况被认为是过敏反应;在进行脱敏治疗期间,右臂的活动范围略有增加。2个月大时,左臂活动范围减小。入院时,病情被视为中度。没有发烧;没有中毒的迹象。皮肤及可见粘膜未见改变。心肺活动令人满意。腹部各隔均可触及,无痛。肝脏增大6cm,呈致密稠度。脾脏肿大5cm。肠道和膀胱功能正常。神经系统状况:检查反应正常,情绪性哭泣。颅神经无病理。能看能听。手臂活动受限;被动的运动是痛苦的。手臂和腿部的肌肉张力较低——更接近生理张力。手臂和腿部的肌腱反射均匀而轻快。大囟门1.5[1]1.5厘米,不突出。前臂骨的x线检查显示两前臂骨骺结构的改变,这是梅毒性骨软骨炎的常见症状。结论。文章描述了复杂性的早期先天性梅毒的诊断在一个2个月大的孩子在没有相应的健全性记忆在他的母亲。有必要排除运动障碍婴儿的梅毒感染,从未经检查的母亲出生,已被强调。
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引用次数: 0
АКТУАЛЬНОСТЬ ГЕНЕТИЧЕСКОЙ ВЕРИФИКАЦИИ НЕКОМПАКТНОЙ КАРДИОМИОПАТИИ У ДЕТЕЙ: КЛИНИЧЕСКИЕ СЛУЧАИ 儿童非紧凑心肌病基因验证的相关性:临床病例
Pub Date : 2018-05-23 DOI: 10.15690/VSP.V17I2.1883
Наталия Андреевна Сдвигова, Елена Николаевна Басаргина, Д В Рябцев, К. В. Савостьянов, А. А. Пушков, Н. В. Журкова, Григорий Валерьевич Ревуненков, О. П. Жарова
Background. Non-compaction cardiomyopathy is a group of genetically heterogeneous, poorly studied myocardial diseases with a variety of clinical manifestations (from asymptomatic course to progressive systolic dysfunction with symptoms of chronic heart failure, arrhythmias, and thromboembolic complications). Considering the variety of genetic disorders associated with the development of noncompaction cardiomyopathy, genetic verification of the diagnosis is important for determining the prognosis and conducting genetic counselling of families with cases of the disease. Description of the Clinical Case. The article presents two clinical observations of a severe course of non-compaction cardiomyopathy with remodeling of the heart cavities according to the dilated phenotype. In order to clarify the disease etiology, a molecular genetic study was conducted using the method of direct automatic sequencing with the analysis of targeted regions of 404 genes which mutations are described in hereditary diseases of the heart and blood vessels. After verifying the mutation (in the ACTC1 and MYBPC3 genes), we performed a search for the detected nucleotide substitution in the venous blood samples of parents and in one case — in the fetal DNA sample. The mode of inheritance has been determined; the probability of recurrence of the disease in siblings in subsequent pregnancies has been estimated. Conclusion. The description of clinical cases shows the importance of genetic verification of the diagnosis in patients with non-compaction cardiomyopathy for determining the disease prognosis and developing an algorithm for monitoring relatives of a proband.
背景。非压实性心肌病是一组遗传异质性的、研究较少的心肌疾病,具有多种临床表现(从无症状到进行性收缩功能障碍,伴有慢性心力衰竭、心律失常和血栓栓塞并发症)。考虑到与非压实性心肌病发展相关的各种遗传疾病,诊断的遗传验证对于确定预后和对患有该疾病的家庭进行遗传咨询非常重要。临床病例描述。本文介绍了两个临床观察严重的非压实性心肌病与重构的心腔根据扩张表型。为了明确疾病的病因,采用直接自动测序的方法,对404个在心脏和血管遗传性疾病中描述突变的基因进行了分子遗传学研究。在验证突变(ACTC1和MYBPC3基因)后,我们在父母静脉血样本和胎儿DNA样本中搜索检测到的核苷酸替代。继承方式已经确定;该疾病在兄弟姐妹随后怀孕中复发的概率已被估计。结论。临床病例的描述显示了非压实性心肌病患者诊断的遗传验证对于确定疾病预后和开发先证亲属监测算法的重要性。
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引用次数: 1
СИСТЕМНАЯ КРАСНАЯ ВОЛЧАНКА: КЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИ. ЧАСТЬ 2 系统红斑狼疮:临床建议。第二部分
Pub Date : 2018-05-22 DOI: 10.15690/VSP.V17I2.1877
Екатерина Иосифовна Алексеева, Т. М. Дворяковская, Ирина Петровна Никишина, Рина Валериановна Денисова, Н. С. Подчерняева, О. А. Сухоруких, Л. С. Шубина, В. Г. Часнык, Михаил Михайлович Костик
The article presents modern ideas about the treatment of systemic lupus erythematosus (SLE). The details of the management of patients with SLE during immunosuppressive and genetically engineered therapy is given. The article also reflects the aspects of rehabilitation, prevention of exacerbations, and follow-up care of children with SLE. The criteria for assessing the quality of medical care for children with SLE are presented. The detailed information on systemic lupus erythematosus for patients with SLE and their parents is outlined specifically.
本文介绍了治疗系统性红斑狼疮(SLE)的现代观念。在免疫抑制和基因工程治疗SLE患者的管理细节给出。文章还反映了SLE患儿的康复、预防病情加重、随访护理等方面。评估儿童SLE医疗护理质量的标准被提出。系统性红斑狼疮患者及其父母的详细信息被特别概述。
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引用次数: 4
РЕЗУЛЬТАТЫ ЛЕЧЕНИЯ ЭТАНЕРЦЕПТОМ ДЕТЕЙ С НЕСИСТЕМНЫМИ ВАРИАНТАМИ ЮВЕНИЛЬНОГО ИДИОПАТИЧЕСКОГО АРТРИТА: ДОСТИЖЕНИЕ РЕМИССИИ, РАЗВИТИЕ ОБОСТРЕНИЙ И НЕЖЕЛАТЕЛЬНЫХ ЯВЛЕНИЙ. РЕТРОСПЕКТИВНОЕ КОГОРТНОЕ ИССЛЕДОВАНИЕ 青少年特发性关节炎非系统性变体儿童治疗结果:缓解、加剧和不良现象。回顾性步兵研究
Pub Date : 2018-05-22 DOI: 10.15690/VSP.V17I2.1880
Михаил Михайлович Костик, И. А. Чикова, Е. А. Исупова, М. Н. Лихачёва, Т. С. Лихачёва, М. Ф. Дубко, В. В. Масалова, Л. С. Снегирёва, Е. В. Гайдар, Ольга Владимировна Калашникова, В. Г. Часнык
Background. Etanercept is a biological drug most commonly used in patients with juvenile idiopathic arthritis (JIA). The results of its use are showed in local studies. Objective. Our aim was to evaluate the efficacy and safety of the use of etanercept in children with non-systemic JIA, to determine the predictors of remission and the risk factors for the development of exacerbations. Methods. In a retrospective cohort study, the results of etanercept treatment (remission, exacerbations, adverse events) in children with non-systemic JIA were analyzed. The minimum follow-up period was 6 months. Results. The period of remission within 6–36 months occurred in 77/131 (58.8%), exacerbations developed in 18/129 (14.0%) patients. Predictors of achieving remission were the age of JIA onset < 8 years [relative risk (RR) 2.05; 95% confidence interval (CI) 1.27–3.23], the age of prescribing etanercept ≤ 10 years (RR 1.7, 95% CI 1.22–2.38), the time of the disease prior to etanercept prescription < 2.5 years (RR 2.4, 95% CI 1.4–4.4), the presence of HLA-B27 antigen (RR 2.15, 95% CI 0.98–4.75; p = 0.06). The risk of exacerbations was higher in children with polyarticular JIA (RR 2.7, 95% CI 0.9–8.2; p = 0.08), whereas methotrexate therapy reduced the risk of exacerbations (RR 0.32, 95% CI 0.1–1.15; p = 0.05). Etanercept was discontinued due to primary (improvement by the ACRpedi criteria after 3 months of therapy <30%) or secondary (loss of previously achieved ≥ 30% improvement) failure in 14/152 (9.2%) patients; de novo uveitis developed in 8/152 (5.3%) patients; reactions at the injection site — in 6/152 (4.0%) patients. Conclusion. Therapy involving etanercept is more likely to induce remission in younger patients with JIA onset at the age of 8 years and a history of less than 2.5 years. A high risk of exacerbations was noted in patients with polyarticular JIA, and low one — in those receiving methotrexate as a part of combined therapy.
背景。依那西普是一种最常用于幼年特发性关节炎(JIA)患者的生物药物。在当地的研究中显示了它的使用结果。目标。我们的目的是评估依那西普在非系统性JIA患儿中的疗效和安全性,以确定缓解的预测因素和恶化发展的危险因素。方法。在一项回顾性队列研究中,分析了依那西普治疗非系统性JIA儿童的结果(缓解、恶化、不良事件)。最小随访期为6个月。结果。77/131(58.8%)患者在6-36个月内出现缓解期,18/129(14.0%)患者出现恶化。缓解的预测因子为JIA发病年龄< 8岁[相对危险度(RR) 2.05;95%可信区间(CI) 1.27 ~ 3.23],开依那西普年龄≤10岁(RR为1.7,95% CI为1.22 ~ 2.38),开依那西普前患病时间< 2.5年(RR为2.4,95% CI为1.4 ~ 4.4),存在HLA-B27抗原(RR为2.15,95% CI为0.98 ~ 4.75;P = 0.06)。多关节性JIA患儿的恶化风险更高(RR 2.7, 95% CI 0.9-8.2;p = 0.08),而甲氨蝶呤治疗降低了恶化的风险(RR 0.32, 95% CI 0.1-1.15;P = 0.05)。依那西普在14/152(9.2%)患者中因原发性(治疗3个月后ACRpedi标准改善<30%)或继发性(先前达到≥30%的改善丧失)失败而停药;152例患者中有8例(5.3%)发生新发葡萄膜炎;注射部位的反应- 6/152(4.0%)例患者。结论。在发病年龄为8岁且病史小于2.5年的年轻JIA患者中,使用依那西普治疗更有可能诱导缓解。多关节性JIA患者的恶化风险较高,而接受甲氨蝶呤联合治疗的患者的恶化风险较低。
{"title":"РЕЗУЛЬТАТЫ ЛЕЧЕНИЯ ЭТАНЕРЦЕПТОМ ДЕТЕЙ С НЕСИСТЕМНЫМИ ВАРИАНТАМИ ЮВЕНИЛЬНОГО ИДИОПАТИЧЕСКОГО АРТРИТА: ДОСТИЖЕНИЕ РЕМИССИИ, РАЗВИТИЕ ОБОСТРЕНИЙ И НЕЖЕЛАТЕЛЬНЫХ ЯВЛЕНИЙ. РЕТРОСПЕКТИВНОЕ КОГОРТНОЕ ИССЛЕДОВАНИЕ","authors":"Михаил Михайлович Костик, И. А. Чикова, Е. А. Исупова, М. Н. Лихачёва, Т. С. Лихачёва, М. Ф. Дубко, В. В. Масалова, Л. С. Снегирёва, Е. В. Гайдар, Ольга Владимировна Калашникова, В. Г. Часнык","doi":"10.15690/VSP.V17I2.1880","DOIUrl":"https://doi.org/10.15690/VSP.V17I2.1880","url":null,"abstract":"Background. Etanercept is a biological drug most commonly used in patients with juvenile idiopathic arthritis (JIA). The results of its use are showed in local studies. Objective. Our aim was to evaluate the efficacy and safety of the use of etanercept in children with non-systemic JIA, to determine the predictors of remission and the risk factors for the development of exacerbations. Methods. In a retrospective cohort study, the results of etanercept treatment (remission, exacerbations, adverse events) in children with non-systemic JIA were analyzed. The minimum follow-up period was 6 months. Results. The period of remission within 6–36 months occurred in 77/131 (58.8%), exacerbations developed in 18/129 (14.0%) patients. Predictors of achieving remission were the age of JIA onset < 8 years [relative risk (RR) 2.05; 95% confidence interval (CI) 1.27–3.23], the age of prescribing etanercept ≤ 10 years (RR 1.7, 95% CI 1.22–2.38), the time of the disease prior to etanercept prescription < 2.5 years (RR 2.4, 95% CI 1.4–4.4), the presence of HLA-B27 antigen (RR 2.15, 95% CI 0.98–4.75; p = 0.06). The risk of exacerbations was higher in children with polyarticular JIA (RR 2.7, 95% CI 0.9–8.2; p = 0.08), whereas methotrexate therapy reduced the risk of exacerbations (RR 0.32, 95% CI 0.1–1.15; p = 0.05). Etanercept was discontinued due to primary (improvement by the ACRpedi criteria after 3 months of therapy <30%) or secondary (loss of previously achieved ≥ 30% improvement) failure in 14/152 (9.2%) patients; de novo uveitis developed in 8/152 (5.3%) patients; reactions at the injection site — in 6/152 (4.0%) patients. Conclusion. Therapy involving etanercept is more likely to induce remission in younger patients with JIA onset at the age of 8 years and a history of less than 2.5 years. A high risk of exacerbations was noted in patients with polyarticular JIA, and low one — in those receiving methotrexate as a part of combined therapy.","PeriodicalId":10919,"journal":{"name":"Current Paediatrics","volume":"229 1","pages":"138-147"},"PeriodicalIF":0.0,"publicationDate":"2018-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77579459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
РЕВМАТИЧЕСКИЕ ЗАБОЛЕВАНИЯ И ЭНДОТЕЛИАЛЬНАЯ ФУНКЦИЯ 风湿病和内皮功能
Pub Date : 2018-05-22 DOI: 10.15690/VSP.V17I2.1878
Варвара Леонидовна Марчук, Николай Васильевич Соботюк, С. В. Бочанцев
The review analyzes the role of chronic inflammatory diseases in the induction of endothelial dysfunction as a factor in the acceleration of atherosclerotic changes in the cardiovascular system. The importance of non-invasive techniques for evaluating endothelial dysfunction to detect preclinical atherosclerotic changes in children and adolescents with rheumatic was discussed. It is postulated that the detection of early signs of endothelial dysfunction in children and adolescents with rheumatic diseases, along with traditional risk factors, should become an integral part of the strategy for preventing adverse cardiovascular events in subsequent age periods.
这篇综述分析了慢性炎症性疾病在诱导内皮功能障碍中的作用,作为加速心血管系统动脉粥样硬化变化的一个因素。讨论了非侵入性技术在评估内皮功能障碍以检测儿童和青少年风湿性关节炎临床前动脉粥样硬化变化中的重要性。据推测,在患有风湿性疾病的儿童和青少年中,内皮功能障碍的早期迹象的检测,以及传统的风险因素,应该成为预防随后年龄阶段不良心血管事件策略的一个组成部分。
{"title":"РЕВМАТИЧЕСКИЕ ЗАБОЛЕВАНИЯ И ЭНДОТЕЛИАЛЬНАЯ ФУНКЦИЯ","authors":"Варвара Леонидовна Марчук, Николай Васильевич Соботюк, С. В. Бочанцев","doi":"10.15690/VSP.V17I2.1878","DOIUrl":"https://doi.org/10.15690/VSP.V17I2.1878","url":null,"abstract":"The review analyzes the role of chronic inflammatory diseases in the induction of endothelial dysfunction as a factor in the acceleration of atherosclerotic changes in the cardiovascular system. The importance of non-invasive techniques for evaluating endothelial dysfunction to detect preclinical atherosclerotic changes in children and adolescents with rheumatic was discussed. It is postulated that the detection of early signs of endothelial dysfunction in children and adolescents with rheumatic diseases, along with traditional risk factors, should become an integral part of the strategy for preventing adverse cardiovascular events in subsequent age periods.","PeriodicalId":10919,"journal":{"name":"Current Paediatrics","volume":"111 1","pages":"126-132"},"PeriodicalIF":0.0,"publicationDate":"2018-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79180255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Клинические проявления и исходы ретинальных кровоизлияний у младенцев: исследование серии случаев
Pub Date : 2018-05-22 DOI: 10.15690/VSP.V17I2.1879
Людмила Викторовна Коголева, Е. Н. Демченко
Background. Retinal hemorrhages in infants are frequent pathologies, but their causes, clinical forms and functional outcomes are poorly studied. The study of hemorrhage localization in the eye structure, time frames of their resolution, and the long-term effects that may affect the development of vision is of particular interest. Objective. Our aim was to analyze clinical forms, time frames of resolution and long-term clinical and functional outcomes of retinal hemorrhages in infants. Methods. All children with retinal hemorrhages, who applied to a premature baby room in the MRI of ED n. a. Helmholtz at the age from 3 weeks to 3 months for 5 years (2011–2015), were examined using indirect ophthalmoscopy. In case of extensive lesions, the process dynamics was controlled by a pediatric digital retinal imaging system. Long-term clinical and functional outcomes of retinal hemorrhages were studied using ultrasound examination and spectral optical coherence tomography. Results. Fundus hemorrhages were revealed in 108 (5.9%) of 1,825 infants on 142 eyes (34 children had bilateral hemorrhages). Hemorrhages were more frequent in children delivered vaginally (79 children, 73.2%), were unilateral (74 children, 63.5%), pre-retinal (108 eyes, 76.1%), of central localization (119 eyes, 83.8%). The time frames of hemorrhage resolution in 53 children (49.1%) were more than one month. Long-term outcomes of retinal hemorrhages were studied in 22 children (33 eyes) at the age of 2–5 years. Residual changes in the structure of the neuroepithelium and vitreoretinal interface with a decrement in visual acuity were noted in 7 children (9 eyes). Conclusion. Retinal hemorrhages of newborns are characterized by clinical polymorphism, different time frames of resolution and outcomes, which requires a case follow-up.
背景。婴儿视网膜出血是常见的病理,但其原因,临床形式和功能结果研究甚少。研究出血在眼睛结构中的定位,其解决的时间框架,以及可能影响视力发展的长期影响是特别感兴趣的。目标。我们的目的是分析婴儿视网膜出血的临床形式、消退的时间框架以及长期的临床和功能结果。方法。2011-2015年期间,所有在ED n. a. Helmholtz MRI早产儿房就诊的3周至3个月的视网膜出血患儿均采用间接眼镜检查。在广泛病变的情况下,过程动力学由儿童数字视网膜成像系统控制。采用超声检查和光谱光学相干断层扫描研究视网膜出血的长期临床和功能结局。结果。1825例患儿142只眼出现眼底出血108例(5.9%),其中34例患儿双侧出血。阴道分娩出血较多(79例,73.2%),单侧出血(74例,63.5%),视网膜前出血(108例,76.1%),中心定位出血(119例,83.8%)。出血消退时间超过1个月53例(49.1%)。研究22例2-5岁儿童(33眼)视网膜出血的长期预后。7例儿童(9眼)发现神经上皮和玻璃体视网膜界面结构残留改变,伴有视力下降。结论。新生儿视网膜出血具有临床多态性、消退时间和预后不同的特点,需要对其进行病例随访。
{"title":"Клинические проявления и исходы ретинальных кровоизлияний у младенцев: исследование серии случаев","authors":"Людмила Викторовна Коголева, Е. Н. Демченко","doi":"10.15690/VSP.V17I2.1879","DOIUrl":"https://doi.org/10.15690/VSP.V17I2.1879","url":null,"abstract":"Background. Retinal hemorrhages in infants are frequent pathologies, but their causes, clinical forms and functional outcomes are poorly studied. The study of hemorrhage localization in the eye structure, time frames of their resolution, and the long-term effects that may affect the development of vision is of particular interest. Objective. Our aim was to analyze clinical forms, time frames of resolution and long-term clinical and functional outcomes of retinal hemorrhages in infants. Methods. All children with retinal hemorrhages, who applied to a premature baby room in the MRI of ED n. a. Helmholtz at the age from 3 weeks to 3 months for 5 years (2011–2015), were examined using indirect ophthalmoscopy. In case of extensive lesions, the process dynamics was controlled by a pediatric digital retinal imaging system. Long-term clinical and functional outcomes of retinal hemorrhages were studied using ultrasound examination and spectral optical coherence tomography. Results. Fundus hemorrhages were revealed in 108 (5.9%) of 1,825 infants on 142 eyes (34 children had bilateral hemorrhages). Hemorrhages were more frequent in children delivered vaginally (79 children, 73.2%), were unilateral (74 children, 63.5%), pre-retinal (108 eyes, 76.1%), of central localization (119 eyes, 83.8%). The time frames of hemorrhage resolution in 53 children (49.1%) were more than one month. Long-term outcomes of retinal hemorrhages were studied in 22 children (33 eyes) at the age of 2–5 years. Residual changes in the structure of the neuroepithelium and vitreoretinal interface with a decrement in visual acuity were noted in 7 children (9 eyes). Conclusion. Retinal hemorrhages of newborns are characterized by clinical polymorphism, different time frames of resolution and outcomes, which requires a case follow-up.","PeriodicalId":10919,"journal":{"name":"Current Paediatrics","volume":"43 1","pages":"133-137"},"PeriodicalIF":0.0,"publicationDate":"2018-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88744016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ГРУДНОЕ МОЛОКО, КАКИМ МЫ ЕГО НЕ ЗНАЛИ: ХРОНОБИОЛОГИЯ ГРУДНОГО МОЛОКА 我们不知道的母乳:母乳的时间生物学
Pub Date : 2018-05-22 DOI: 10.15690/VSP.V17I2.1881
С. Е. Украинцев, Т. Н. Самаль
The article analyzes modern scientific data on the changes in breast milk composition during lactation. These changes affect both short-term (sleep, appetite) and long-term parameters (growth and development, temperament, behavior) with respect to the health of the child. This information will help to have a better idea of the benefits of breast milk and breastfeeding for a child and to strengthen a support and promotion of breastfeeding among mothers and health workers.
本文分析了哺乳期间母乳成分变化的现代科学数据。这些变化影响儿童健康方面的短期(睡眠、食欲)和长期参数(生长发育、气质、行为)。这些信息将有助于更好地了解母乳和母乳喂养对儿童的好处,并加强对母亲和卫生工作者中母乳喂养的支持和促进。
{"title":"ГРУДНОЕ МОЛОКО, КАКИМ МЫ ЕГО НЕ ЗНАЛИ: ХРОНОБИОЛОГИЯ ГРУДНОГО МОЛОКА","authors":"С. Е. Украинцев, Т. Н. Самаль","doi":"10.15690/VSP.V17I2.1881","DOIUrl":"https://doi.org/10.15690/VSP.V17I2.1881","url":null,"abstract":"The article analyzes modern scientific data on the changes in breast milk composition during lactation. These changes affect both short-term (sleep, appetite) and long-term parameters (growth and development, temperament, behavior) with respect to the health of the child. This information will help to have a better idea of the benefits of breast milk and breastfeeding for a child and to strengthen a support and promotion of breastfeeding among mothers and health workers.","PeriodicalId":10919,"journal":{"name":"Current Paediatrics","volume":"5 1","pages":"148-151"},"PeriodicalIF":0.0,"publicationDate":"2018-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75020936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Роль нарушений эпидермального барьера при атопическом дерматите: современные концепции патогенеза заболевания 原子皮肤病表皮障碍障碍障碍的作用:疾病病原体的现代概念
Pub Date : 2018-04-02 DOI: 10.15690/VSP.V17I1.1859
Н. Н. Мурашкин, Э. Т. Амбарчян, А. И. Материкин, Р. В. Епишев
Atopic dermatitis is a common chronic inflammatory skin disease characterized by a recurring course and progressive decrease in the quality of life. Recent studies in this area demonstrate the multifaceted pathogenesis of atopic dermatitis. Interaction of such factors as epidermal dysfunction, immune system disorders, and the consequences of genetic mutations contributes not only to the development of the disease but also to its progression and chronic course. The article presents various components of the etiopathogenesis of atopic dermatitis, describes the role of lipids, thereby the new therapeutic targets are revealed to specialists.
特应性皮炎是一种常见的慢性炎症性皮肤病,其特点是病程反复发作,生活质量逐渐下降。近年来的研究表明,特应性皮炎的发病机制是多方面的。表皮功能障碍、免疫系统紊乱和基因突变的后果等因素的相互作用不仅有助于疾病的发生,而且有助于其进展和慢性病程。文章介绍了特应性皮炎的发病机制的各种组成部分,描述了脂质的作用,从而揭示了新的治疗目标的专家。
{"title":"Роль нарушений эпидермального барьера при атопическом дерматите: современные концепции патогенеза заболевания","authors":"Н. Н. Мурашкин, Э. Т. Амбарчян, А. И. Материкин, Р. В. Епишев","doi":"10.15690/VSP.V17I1.1859","DOIUrl":"https://doi.org/10.15690/VSP.V17I1.1859","url":null,"abstract":"Atopic dermatitis is a common chronic inflammatory skin disease characterized by a recurring course and progressive decrease in the quality of life. Recent studies in this area demonstrate the multifaceted pathogenesis of atopic dermatitis. Interaction of such factors as epidermal dysfunction, immune system disorders, and the consequences of genetic mutations contributes not only to the development of the disease but also to its progression and chronic course. The article presents various components of the etiopathogenesis of atopic dermatitis, describes the role of lipids, thereby the new therapeutic targets are revealed to specialists.","PeriodicalId":10919,"journal":{"name":"Current Paediatrics","volume":"4 1","pages":"85-88"},"PeriodicalIF":0.0,"publicationDate":"2018-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86367734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
«КЛИНИЧЕСКИЕ МАСКИ» КОСТНЫХ САРКОМ У ДЕТЕЙ: ШЕСТЬ КЛИНИЧЕСКИХ СЛУЧАЕВ 儿童骨骼肉瘤“临床面具”:6例临床病例
Pub Date : 2018-04-02 DOI: 10.15690/vsp.v17i1.1860
М. Ю. Рыков
Background. Solid tumors in children are one of the most common childhood malignancy, second only to hemoblastosis. Among solid tumours, about 5% are bone sarcomas: osteosarcoma (3%) and Ewing's sarcoma (2%). Atypicality of the these diseases course makes an early diagnosis a real challenge. Case Reports. The article presents six clinical observations of patients with bone sarcomas. We demonstrate the difficulties in diagnosing of this disease group which is associated with the absence of both specific symptoms and  distinct clinical picture. Conclusion. Pediatricians and pediatric surgeons should take into account the possibility of atypical course of bone sarcomas in children. Low cancer alertness is the reason for a significant delay in establishing the correct diagnosis which contributes to the tumour process generalization and reduces the chances of achieving remission while increasing the cost of treating such patients.
背景。儿童实体瘤是最常见的儿童恶性肿瘤之一,仅次于造血细胞病。在实体瘤中,约5%为骨肉瘤:骨肉瘤(3%)和尤文氏肉瘤(2%)。这些疾病病程的非典型性使得早期诊断成为一个真正的挑战。案例报告。本文报道骨肉瘤患者的6例临床观察。我们证明在诊断这一疾病组的困难,这是与缺乏具体症状和明确的临床图片。结论。儿科医生和儿科外科医生应考虑到儿童骨肉瘤非典型病程的可能性。低癌症警觉性是建立正确诊断的显著延迟的原因,这有助于肿瘤过程的泛化,降低了实现缓解的机会,同时增加了治疗此类患者的成本。
{"title":"«КЛИНИЧЕСКИЕ МАСКИ» КОСТНЫХ САРКОМ У ДЕТЕЙ: ШЕСТЬ КЛИНИЧЕСКИХ СЛУЧАЕВ","authors":"М. Ю. Рыков","doi":"10.15690/vsp.v17i1.1860","DOIUrl":"https://doi.org/10.15690/vsp.v17i1.1860","url":null,"abstract":"Background. Solid tumors in children are one of the most common childhood malignancy, second only to hemoblastosis. Among solid tumours, about 5% are bone sarcomas: osteosarcoma (3%) and Ewing's sarcoma (2%). Atypicality of the these diseases course makes an early diagnosis a real challenge. Case Reports. The article presents six clinical observations of patients with bone sarcomas. We demonstrate the difficulties in diagnosing of this disease group which is associated with the absence of both specific symptoms and  distinct clinical picture. Conclusion. Pediatricians and pediatric surgeons should take into account the possibility of atypical course of bone sarcomas in children. Low cancer alertness is the reason for a significant delay in establishing the correct diagnosis which contributes to the tumour process generalization and reduces the chances of achieving remission while increasing the cost of treating such patients.","PeriodicalId":10919,"journal":{"name":"Current Paediatrics","volume":"111 1","pages":"89-93"},"PeriodicalIF":0.0,"publicationDate":"2018-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79300692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
期刊
Current Paediatrics
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