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Artificial Neural Networks in Membrane Bioreactors: A Comprehensive Review—Overcoming Challenges and Future Perspectives 人工神经网络在膜生物反应器中的应用综述——克服挑战与展望
Pub Date : 2023-08-15 DOI: 10.3390/sci5030031
Z. Frontistis, Grigoris Lykogiannis, Anastasios Sarmpanis
Among different biological methods used for advanced wastewater treatment, membrane bioreactors have demonstrated superior efficiency due to their hybrid nature, combining biological and physical processes. However, their efficient operation and control remain challenging due to their complexity. This comprehensive review summarizes the potential of artificial neural networks (ANNs) to monitor, simulate, optimize, and control these systems. ANNs show a unique ability to reveal and simulate complex relationships of dynamic systems such as MBRs, allowing for process optimization and fault detection. This early warning system leads to increased reliability and performance. Integrating ANNs with advanced algorithms and implementing Internet of Things (IoT) devices and new-generation sensors has the potential to transform the advanced wastewater treatment landscape towards the development of smart, self-adaptive systems. Nevertheless, several challenges must be addressed, including the need for high-quality and large-quantity data, human resource training, and integration into existing control system facilities. Since the demand for advanced water treatment and water reuse will continue to expand, proper implementation of ANNs, combined with other AI tools, is an exciting strategy toward the development of integrated and efficient advanced water treatment schemes.
在各种用于污水深度处理的生物方法中,膜生物反应器由于其结合生物和物理过程的混合性而表现出优越的效率。然而,由于其复杂性,有效的操作和控制仍然具有挑战性。本文综述了人工神经网络(ANNs)在监测、模拟、优化和控制这些系统方面的潜力。人工神经网络显示出一种独特的能力,可以揭示和模拟动态系统(如mbr)的复杂关系,从而实现过程优化和故障检测。这种早期预警系统提高了可靠性和性能。将人工神经网络与先进的算法集成,并实施物联网(IoT)设备和新一代传感器,有可能将先进的废水处理领域转变为智能、自适应系统的发展。然而,必须解决若干挑战,包括对高质量和大量数据的需求、人力资源培训以及与现有控制系统设施的集成。由于对高级水处理和水回用的需求将继续扩大,适当实施人工神经网络,结合其他人工智能工具,是开发综合高效高级水处理方案的一项令人兴奋的战略。
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引用次数: 0
Short-Term Biochemical Biomarkers of Stress in the Oyster Magallana angulata Exposed to Gymnodinium catenatum and Skeletonema marinoi 长角麦哲伦牡蛎暴露于连翘裸子和马里诺骨骼肌胁迫下的短期生化生物标志物
Pub Date : 2023-07-17 DOI: 10.3390/sci5030030
R. Cereja, J. Cruz, J. Heumüller, B. Vicente, A. Amorim, Frederico Carvalho, S. Cabral, P. Chainho, A. Brito, I. Ferreira, M. Diniz
Bivalves accumulate toxins produced by microalgae, thus becoming harmful for humans. However, little information is available about their toxicity to the bivalve itself. In the present work, the physiological stress and damage after the ingestion of toxic dinoflagellate species (Gymnodinium catenatum) and a diatom species (Skeletonema marinoi, which is non-toxic to humans but may be to grazers) in the oyster Magallana angulata are evaluated against a control treatment fed with the chlorophyte Tetraselmis sp. Oysters were exposed for two hours to a concentration of 4 × 104 cells/L of G. catenatum and 2 × 107 cells/L of S. marinoi. The biomarkers superoxide dismutase (SOD), catalase (CAT), glutathione S-Transferase, total Ubiquitin (Ubi) and Acetylcholinesterase (AchE) were assessed. The exposure of M. angulata to G. catenatum lead to a reduction in SOD and AchE activity and ubiquitin concentrations when compared to the control treatment. Moreover, it increased CAT activity in the adductor muscle, and maintained its activity in the other tissues tested. This may be related to the combination of reduced metabolism with the deployment of detoxification processes. S. marinoi also lead to a decrease in all biomarkers tested in the gills and digestive glands. Therefore, both species tested caused physiological alterations in M. angulata after two hours of exposure.
双壳类积累微藻产生的毒素,对人体有害。然而,关于它们对双壳类动物本身的毒性的信息很少。在本研究中,以绿藻Tetraselmis sp为对照,研究了食入有毒鞭毛藻(Gymnodinium catenatum)和一种硅藻(对人类无毒但对食草动物可能有害的marinoi)对Magallana angulata牡蛎的生理应激和损害。牡蛎分别暴露于浓度为4 × 104个细胞/L的catenatum和2 × 107个细胞/L的S. marinoi中2小时。检测生物标志物超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽s -转移酶、总泛素(Ubi)和乙酰胆碱酯酶(AchE)。与对照处理相比,角田鼠暴露于连翘草导致SOD、AchE活性和泛素浓度降低。此外,它增加了内收肌中CAT的活性,并保持了其在其他组织中的活性。这可能与代谢减少与解毒过程的部署相结合有关。S. marinoi还会导致鳃和消化腺中所有生物标志物的减少。因此,两种被测物种在暴露两小时后都引起了角田鼠的生理变化。
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引用次数: 0
Implementing Smart Services in Small- and Medium-Sized Manufacturing Companies: On the Progress of Servitization in the Era of Industry 4.0 中小制造企业实施智能服务:论工业4.0时代的服务化进程
Pub Date : 2023-07-12 DOI: 10.3390/sci5030029
J. Winter
For a long time, the challenge has been to provide products and services that precisely match the preferences, habits, and needs of users [...]
长期以来,所面临的挑战一直是提供与用户的偏好、习惯和需求精确匹配的产品和服务[…]
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引用次数: 0
COVID-19 as a Jump Start for Industry 4.0? Motivations and Core Areas of Pandemic-Related Investments in Digital Technologies at German Firms 2019冠状病毒病是工业4.0的起点?德国公司在数字技术方面与流行病相关投资的动机和核心领域
Pub Date : 2023-07-07 DOI: 10.3390/sci5030028
Florian Butollo, Jana Flemming, Christine Gerber, Martin Krzywdzinski, David Wandjo, Nina Delicat, Lorena Herzog
Academic studies prior to the pandemic rather emphasized that the progression towards Industry 4.0 happened in an incremental manner. However, the extraordinary circumstances of the pandemic have led to considerable investments that were widely interpreted as a (generalized) digitalization push. However, little is known about the character of such investments and their effects. The goal of this contribution is to provide an empirically based overview of recent investment in digital technologies in six economic sectors of the German economy: mechanical engineering, chemicals, automotives, logistics, healthcare, and financial services. Based on 36 case studies and a survey at 540 companies, we investigate the following questions: 1. How much did the COVID-19 pandemic reduce existing obstacles for investments in digitalization measures? 2. Is there a universal digitalization push due to the COVID-19 pandemic that differs from the trajectory before the pandemic? The results show that the pandemic affected investment in an unequal manner. It was driven by the immediate need to sustain business operations through the virtualization of communication among employees and with external partners. However, there was less dynamism in shop-floor-related digitalization, as it was less related to epidemiological concerns and is more long-term in nature.
疫情前的学术研究强调,工业4.0的进程是以渐进的方式进行的。然而,大流行的特殊情况导致了大量投资,这些投资被广泛解释为(广泛的)数字化推动。然而,人们对这种投资的性质及其影响知之甚少。这篇文章的目标是对德国经济的六个经济部门(机械工程、化工、汽车、物流、医疗保健和金融服务)最近在数字技术方面的投资进行基于经验的概述。基于36个案例研究和对540家公司的调查,我们调查了以下问题:COVID-19大流行在多大程度上减少了对数字化措施投资的现有障碍?2. 由于COVID-19大流行,是否存在与大流行之前不同的普遍数字化推动?结果表明,疫情对投资的影响是不平等的。它是由通过员工之间以及与外部合作伙伴之间的通信虚拟化来维持业务运营的迫切需求所驱动的。然而,与车间相关的数字化的活力较小,因为它与流行病学问题的关系较小,性质上更具长期性。
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引用次数: 0
Sensory and Cognitive Malingering: Studies and Tests 感觉和认知装病:研究和测试
Pub Date : 2023-07-06 DOI: 10.3390/sci5030027
G. Zucco, G. Sartori
Malingering relates to intentionally pretending or exaggerating physical or psychologic symptoms to gain an external incentive, such as avoiding work, law prosecution or military service, or seeking financial compensation from insurance companies. Accordingly, various techniques have been developed in recent years by the scientific community to address this challenge. In this review, we discuss malingering within visual, auditory and olfactory domains, as well as in cognitive disorders and psychopathology. We provide a general, critical, narrative overview on the intermodal criteria for differential diagnosis, and discuss validated psychophysical tools and electrophysiology-based tests for its detection, as well as insights for future directions.
装病是指故意假装或夸大身体或心理症状,以获得外部激励,例如逃避工作、被起诉或服兵役,或向保险公司寻求经济赔偿。因此,近年来科学界开发了各种技术来应对这一挑战。在这篇综述中,我们讨论装病在视觉,听觉和嗅觉领域,以及在认知障碍和精神病理学。我们对鉴别诊断的多式联运标准提供了一般性、批判性、叙述性的概述,并讨论了有效的心理物理工具和基于电生理学的检测方法,以及对未来方向的见解。
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引用次数: 0
Transcriptomics Analysis of Tomato Ripening Regulated by Carbon Dioxide 二氧化碳调控番茄成熟的转录组学分析
Pub Date : 2023-06-30 DOI: 10.3390/sci5030026
J. Bobokalonov, Yanhong Liu, Karley K. Mahalak, Jenni Firrman, S. Sheen, Siyuan Zhou, Linshu Liu
Tomatoes are a perishable and seasonal fruit with a high economic impact. Carbon dioxide (CO2), among several other reagents, is used to extend the shelf-life and preserve the quality of tomatoes during refrigeration or packaging. To obtain insight into CO2 stress during tomato ripening, tomatoes at the late green mature stage were conditioned with one of two CO2 delivery methods: 5% CO2 for 14 days (T1) or 100% CO2 for 3 h (T2). Conventional physical and chemical characterization found that CO2 induced by either T1 or T2 delayed tomato ripening in terms of color change, firmness, and carbohydrate dissolution. However, T1 had longer-lasting effects. Furthermore, ethylene production was suppressed by CO2 in T1, and promoted in T2. These physical observations were further evaluated via RNA-Seq analysis at the whole-genome level, including genes involved in ethylene synthesis, signal transduction, and carotenoid biosynthesis. Transcriptomics analysis revealed that the introduction of CO2 via the T1 method downregulated genes related to fruit ripening; in contrast, T2 upregulated the gene encoding for ACS6, the enzyme responsible for S1 ethylene synthesis, even though there was a large amount of ethylene present, indicating that T1 and T2 regulate tomato ripening via different mechanisms. Quantitative real-time PCR assays (qRT-PCR) were used for validation, which substantiated the RNA-Seq data. The results of the present research provide insight into gene regulation by CO2 during tomato ripening at the whole-genome level.
西红柿是一种易腐烂的时令水果,具有很高的经济效益。在其他几种试剂中,二氧化碳(CO2)用于延长番茄的保质期,并在冷藏或包装期间保持其质量。为了深入了解番茄成熟过程中的二氧化碳胁迫,研究人员对绿成熟后期的番茄进行了两种CO2输送方法之一的调节:5% CO2 14天(T1)或100% CO2 3小时(T2)。常规理化表征发现,T1或T2诱导的CO2在颜色变化、硬度和碳水化合物溶解方面延迟了番茄的成熟。然而,T1有更持久的效果。此外,CO2在T1阶段抑制了乙烯的生成,在T2阶段促进了乙烯的生成。这些物理观察结果通过全基因组水平的RNA-Seq分析进一步评估,包括参与乙烯合成、信号转导和类胡萝卜素生物合成的基因。转录组学分析表明,通过T1方法引入CO2可下调果实成熟相关基因;相比之下,即使存在大量乙烯,T2也上调了负责S1乙烯合成酶ACS6的基因编码,这表明T1和T2通过不同的机制调节番茄成熟。采用实时荧光定量PCR (qRT-PCR)进行验证,证实了RNA-Seq数据。本研究的结果提供了在全基因组水平上对番茄成熟过程中二氧化碳基因调控的见解。
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引用次数: 0
Conventional Platinum Metal Implants Provoke Restenosis Responses in Atherogenic but Not Healthy Arteries 传统的铂金属植入物可引起动脉粥样硬化而非健康动脉的再狭窄反应
Pub Date : 2023-06-19 DOI: 10.3390/sci5020025
Lea M. Morath, Roger J. Guillory, A. A. Oliver, S. Q. Liu, Martin L. Bocks, G. Levy, J. Drelich, J. Goldman
Platinum-containing stents are commonly used in humans with hypercholesterolemia, whereas preclinical stent evaluation has commonly been performed in healthy animal models, providing inadequate information about stent performance under hypercholesterolemic conditions. In this investigation, we used an ApoE−/− mouse model to test the impact of hypercholesterolemia on neointima formation on platinum-containing implants. We implanted 125 μm diameter platinum wires into the abdominal aortas of ApoE−/− and ApoE+/+ mice for 6 months, followed by histological and immunofluorescence examination of neointimal size and composition. It was found that ApoE−/− mice developed neointimas with four times larger area and ten times greater thickness than ApoE+/+ counterparts. Neointimas developed in the ApoE−/− mice also contained higher amounts of lipids quantified as having 370 times more coverage compared to ApoE+/+, a 3-fold increase in SMCs, and a 22-fold increase in macrophages. A confluent endothelium had regenerated in both mouse strains. The ApoE−/− mice experienced luminal reductions more closely resembling clinically relevant restenosis in humans. Overall, the response to platinum arterial implants was highly dependent upon the atherogenic environment.
含铂支架通常用于高胆固醇血症患者,然而临床前支架评估通常在健康动物模型中进行,提供的关于高胆固醇血症条件下支架性能的信息不足。在这项研究中,我们使用ApoE - / -小鼠模型来测试高胆固醇血症对含铂植入物新内膜形成的影响。我们将直径125 μm的铂丝植入ApoE−/−和ApoE+/+小鼠腹主动脉6个月,然后对新内膜的大小和组成进行组织学和免疫荧光检测。结果发现,与ApoE+/+小鼠相比,ApoE−/−小鼠形成的新内膜面积大4倍,厚度大10倍。与ApoE+/+相比,ApoE−/−小鼠中形成的新内膜含有更多的脂质,其覆盖范围是ApoE+/+的370倍,SMCs增加了3倍,巨噬细胞增加了22倍。两个小鼠品系均再生了合流内皮。ApoE−/−小鼠经历的管腔减少更接近于人类临床相关的再狭窄。总的来说,对铂动脉植入物的反应高度依赖于动脉粥样硬化环境。
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引用次数: 0
Assessment of Spatial Variations in Pesticide, Heavy Metal, and Selenium Residues in Honey Bee (Apis mellifera L.) Products 蜜蜂体内农药、重金属和硒残留的空间分异研究产品
Pub Date : 2023-06-06 DOI: 10.3390/sci5020024
M. Awad, R. Boone
Apis mellifera L. is considered one of the most important pollinators in nature. Unfortunately, in addition to other insect species, honey bee populations are decreasing at an alarming rate, urging researchers to investigate the causes and stressors that precipitated this decline. This study focuses on chemical stressors that are found to affect bee populations. We used pollen and honey samples to examine the variations in pesticides, selenium, and heavy metals in two different landscapes: urban and agricultural areas of northeastern Colorado, USA. Subsequently, we extrapolated the risks of these toxins’ residues to Apis spp. Based on the current literature, we found no spatial variations in metal and selenium concentrations in the pollen and honey samples collected from urban and agricultural areas. Moreover, we observed no spatial variations in pesticide concentrations in pollen and honey samples. Based on the previous literature and a comparison of the residues of heavy metals, selenium, and pesticides in our pollen and honey samples, we found that the heavy metal and selenium residues in some honey and pollen likely pose a severe health risk to honey bees. Although the levels of pesticide residues were below the documented thresholds of risk, we consider the possibility of synergistic chemical impacts. Our findings support future efforts to investigate the health risks associated with multiple-factor combinations.
蜜蜂被认为是自然界最重要的传粉媒介之一。不幸的是,除了其他昆虫物种外,蜜蜂的数量也在以惊人的速度减少,这促使研究人员调查导致这种下降的原因和压力源。这项研究的重点是发现影响蜜蜂种群的化学压力源。我们使用花粉和蜂蜜样本来检测杀虫剂、硒和重金属在两种不同景观中的变化:美国科罗拉多州东北部的城市和农业地区。根据目前的文献,我们发现城市和农业地区采集的花粉和蜂蜜样品中金属和硒的浓度没有空间差异。此外,我们观察到花粉和蜂蜜样品中农药浓度没有空间变化。根据之前的文献和我们的花粉和蜂蜜样品中重金属、硒和农药残留的比较,我们发现一些蜂蜜和花粉中的重金属和硒残留可能对蜜蜂造成严重的健康风险。虽然农药残留水平低于记录的风险阈值,但我们考虑了协同化学影响的可能性。我们的发现支持了未来调查与多因素组合相关的健康风险的努力。
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引用次数: 0
A Survey on EEG Data Analysis Software 脑电数据分析软件综述
Pub Date : 2023-06-01 DOI: 10.3390/sci5020023
Rupak Kumar Das, Anna Martin, Tom Zurales, Dale Dowling, Arshia A. Khan
Electroencephalography (EEG) is a mechanism to understand the brain’s functioning by analyzing brain electrical signals. More recently, it has been more commonly used in studies that are focused on the causation and effect of dementia. More tools are now available to gather EEG data. This brings about the challenge of understanding brain signals, which involves signal processing. Professionals with an electrical engineering background are very comfortable analyzing EEG data. Still, scientists in computer science and related fields need a source that can identify all the tools available and the process of analyzing the data. This paper deals specifically with the existing EEG data analysis tools and the processes involved in analyzing the EEG data using these tools. Furthermore, the paper goes in-depth into identifying the tools and the mechanisms of data processing techniques. In addition, it lists a set of definitions required for a better understanding of EEG data analysis, which can be challenging. The purpose of this paper is to serve as a reference for not only scientists that are new to EEG data analysis but also seasoned scientists that are looking for a specific data component in EEG and can go straight to the section of the paper that deals with the tool that they are using.
脑电图(EEG)是一种通过分析脑电信号来了解大脑功能的机制。最近,它更常用于关注痴呆症的因果关系的研究中。现在有更多的工具可用于收集脑电图数据。这就带来了理解大脑信号的挑战,这涉及到信号处理。具有电气工程背景的专业人员非常擅长分析脑电图数据。尽管如此,计算机科学和相关领域的科学家需要一个能够识别所有可用工具和分析数据过程的来源。本文详细介绍了现有的脑电数据分析工具以及使用这些工具分析脑电数据所涉及的过程。此外,本文还深入探讨了数据处理技术的工具和机制。此外,它还列出了更好地理解EEG数据分析所需的一组定义,这可能具有挑战性。本文的目的不仅是为刚接触脑电图数据分析的科学家提供参考,也为那些在脑电图中寻找特定数据成分的资深科学家提供参考,他们可以直接进入论文中处理他们正在使用的工具的部分。
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引用次数: 3
Digital Factory Transformation from a Servitization Perspective: Fields of Action for Developing Internal Smart Services 服务化视角下的数字化工厂转型:开发内部智能服务的行动领域
Pub Date : 2023-05-16 DOI: 10.3390/sci5020022
Jens Neuhüttler, Maximilian Feike, Janika Kutz, Christian Blümel, B. Bienzeisler
In recent years, a complex set of dynamic developments driven by both the economy and the emergence of digital technologies has put pressure on manufacturing companies to adapt. The concept of servitization, i.e., the shift from a product-centric to a service-centric value creation logic, can help manufacturing companies stabilize their business in such volatile times. Existing academic literature investigates the potential and challenges of servitization and the associated development of data-based services, so-called smart services, with a view to external market performance. However, with the increasing use of digital technologies in manufacturing and the development of internal smart services based on them, we argue that the existing insights on external servitization are also of interest for internal transformation. In this paper, we identify key findings from service literature, apply them to digital factory transformation, and structure them into six fields of action along the dimensions of people, technology, and organization. As a result, recommendations for designing digital factory transformation in manufacturing companies are derived from the perspective of servitization and developing internal smart services.
近年来,在经济和数字技术的双重驱动下,一系列复杂的动态发展给制造企业带来了适应压力。服务化的概念,即从以产品为中心的价值创造逻辑向以服务为中心的价值创造逻辑的转变,可以帮助制造企业在这种动荡的时期稳定其业务。现有的学术文献调查了服务化的潜力和挑战,以及基于数据的服务(所谓的智能服务)的相关发展,并着眼于外部市场绩效。然而,随着数字技术在制造业中的应用越来越多,以及基于数字技术的内部智能服务的发展,我们认为,现有的外部服务化见解对内部转型也很有意义。在本文中,我们确定了服务文献中的关键发现,将其应用于数字化工厂转型,并沿着人员、技术和组织的维度将其构建为六个行动领域。因此,从服务化和开发内部智能服务的角度出发,提出了制造企业数字化工厂转型设计的建议。
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引用次数: 1
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