Current aging science最新文献

Background: Self-defining future projections (SDFP) are mental representations of plausible and highly significant future events that provide core information of one's understanding of self.

Objective: We explored SDFPs in a large sample of older adults and aimed to target the interrelations between the main dimensions of SDFPs. Moreover, correlations between these dimensions and clinical and cognitive variables were examined.

Methods: We recruited 87 young-old adults (60-75 years) with normal cognitive functioning who were asked to generate three SDFPs.

Results: We found integrative meaning as a salient dimension and older individuals preferentially generated projections containing leisure or relationship events. Anxiety and self-esteem were correlated with integrative meaning and high executive functioning was found to be protective towards the simulation of future events containing dependence and death or end-of-life events.

Conclusion: This study will contribute to the understanding of personal goals and identity in normal ageing.

Background: MLC601 and MLC901 showed neuroprotective and neuroregenerative properties and positive results in the treatment of dementia and cognitive impairment. This study aimed to investigate the long-term benefits of monotherapy with MLC601 and MLC901 in patients with Alzheimer's disease (AD).

Methods: In this study, patients with AD, diagnosed by DSM-IV criteria, were enrolled. Patients have received MLC601 for four years, and their regimen has changed to MLC901 for another four years. Recruited patients were followed to assess the efficacy and safety first of MLC601 and MLC901. Mini-Mental State Examination (MMSE) and Alzheimer's Disease Assessment Scale- Cognitive Subscale (ADAS-Cog) were used to assess cognitive function. Safety was evaluated by monitoring adverse events (AEs) and abnormal findings in physical examinations or lab tests.

Results: At the end of the trial, the changes in the mean (±SD) MMSE and ADAS-Cog scores were 5.1 (3.09) and 12.5 (10.89), respectively. Both scores showed a significant change in repeated measure analysis, with the ADAS-Cog score indicating a higher change than the MMSE score (P < 0.001).

Conclusion: For more than eight years, we studied monotherapy with NeuroAid (MLC601, MLC901) in patients with AD. The study contributes further to the long-term safety and efficacy data of MLC in patients with AD.

Introduction: The time spent in different physical activity (PA) intensities is associated with sarcopenia risk for community-dwelling older women.

Aim: To evaluate the role of sitting time and physical activity (PA) level as predictors of sarcopenia odds.

Methods: In a cross-sectional study, physically independent older women (n = 67) performed the six-minute walk test to identify functional limitation (≤ 400 m). Sedentary time (as sitting time) and PA (light, moderate and vigorous) were obtained with the International Physical Activity Questionnaire (IPAQ). Sarcopenia was diagnosed as recommended by the Society of Sarcopenia, Cachexia and Wasting Disorders (SCWD). Sarcopenia odds (low muscle mass and functional limitation) was predicted by binary logistic regression, considering the weekly sitting time and PA as independent variables.

Results: Sarcopenia prevalence was 7.5% (n = 5), with functional limitation present in 38.8% (n = 26), and low muscle mass in 22.4% (n = 15). The predictive model (p = 0.014) involved moderate PA as the only significant predictor (OR = 0.999; p = 0.005; 95% CI: 0.998-1.000) of functional limitation. Moderate PA prevents sarcopenia odds. Each weekly hour of moderate PA decreased sarcopenia odds by 6%.

Conclusion: Time spent in moderate PA can prevent sarcopenia.

Populations are ageing at varying rates of development. Countries with developed economies have experienced such changes to their population structures. Examinations have been conducted with regard to how respective societies can accommodate the said changes in their health and social systems, but this research mostly focuses on more developed regions rather than lowerincome countries. This paper discussed the experience of ageing populations in developing economies, which comprise the majority of the global older population. They display a vastly different experience from high-income countries, especially when viewed within the level of world regions. The cases presented here were from Southeast Asian countries in order to have a wide range of examples in terms of differences in country-income categories. In lower and middle-income countries, there are older adults who: continue working as their primary income source, are nonmembers of pension systems, and provide intergenerational support rather than only receiving it. The COVID-19 pandemic situation was also included here, as policies were reformed to address current needs that highlighted the challenging situation of older adults. The populations of countries that have yet to age substantially, especially those in the least-developed regions, can utilise this paper's recommendations in order to prepare for changes in the age structures of their societies.