Pub Date : 2024-10-09DOI: 10.2174/0118746098320942240924074044
Celi Macedo Polo, Tábatta Renata Pereira de Brito, Wanderson Roberto Silva, Daniela Braga Lima, Daniella Pires Nunes, Fábio Antonio Colombo, Ariene Angelini Dos Santos Orlandi, Ligiana Pires Corona
Background: Telomere length has been investigated as a biomarker of biological aging and is associated with several diseases, lifestyle, and socioeconomic factors.
Objective: This study aimed to verify whether food insecurity is associated with shorter telomere length in older people.
Methods: This is a cross-sectional study carried out in a municipality in the interior of Brazil, with a sample of 440 older people from the community. For telomere length analysis, a blood sample was obtained from each participant, followed by real-time qPCR, and sociodemographic and health information was collected through interviews. Food security/insecurity was measured using the reduced version of the Brazilian Food Insecurity Scale. Descriptive analysis and multiple logistic regression were performed to analyze the factors associated with shorter telomere length, adopting a significance level of 5%.
Results: We found that food insecurity was significantly associated with shorter telomere length, regardless of age group, skin color, tabagism, physical activity, milk and dairy consumption, living arrangement, and basic activities of daily life.
Conclusion: The findings show the importance of ensuring full access to adequate nutrition for the older population, who are physiologically and socially vulnerable.
{"title":"Shorter Telomere Length is Associated with Food Insecurity in Older People: A Cross-Sectional Study.","authors":"Celi Macedo Polo, Tábatta Renata Pereira de Brito, Wanderson Roberto Silva, Daniela Braga Lima, Daniella Pires Nunes, Fábio Antonio Colombo, Ariene Angelini Dos Santos Orlandi, Ligiana Pires Corona","doi":"10.2174/0118746098320942240924074044","DOIUrl":"https://doi.org/10.2174/0118746098320942240924074044","url":null,"abstract":"<p><strong>Background: </strong>Telomere length has been investigated as a biomarker of biological aging and is associated with several diseases, lifestyle, and socioeconomic factors.</p><p><strong>Objective: </strong>This study aimed to verify whether food insecurity is associated with shorter telomere length in older people.</p><p><strong>Methods: </strong>This is a cross-sectional study carried out in a municipality in the interior of Brazil, with a sample of 440 older people from the community. For telomere length analysis, a blood sample was obtained from each participant, followed by real-time qPCR, and sociodemographic and health information was collected through interviews. Food security/insecurity was measured using the reduced version of the Brazilian Food Insecurity Scale. Descriptive analysis and multiple logistic regression were performed to analyze the factors associated with shorter telomere length, adopting a significance level of 5%.</p><p><strong>Results: </strong>We found that food insecurity was significantly associated with shorter telomere length, regardless of age group, skin color, tabagism, physical activity, milk and dairy consumption, living arrangement, and basic activities of daily life.</p><p><strong>Conclusion: </strong>The findings show the importance of ensuring full access to adequate nutrition for the older population, who are physiologically and socially vulnerable.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-12DOI: 10.2174/0118746098302999240522092726
Dewi Shinta Kemala Sari, N. Lipoeto, Hafni Bachtiar, Indra Catri, Nina Kemala Sari, Rima Semiarty
The growing elderly population in Indonesia presents challenges for the healthcare system, prompting the exploration of telemedicine as a solution. However, its effective implementation in Indonesia faces obstacles. This research aimed to develop a comprehensive geriatric telemedicine framework in Padang City by studying multiple stakeholders. We employed qualitative methods, including in- -depth interviews, across two hospitals, a Health Office, and a Community Health Center, involving 18 elderly participants. The study identified ten key dimensions for geriatric telemedicine services: technology, Human-Computer Interface (HCI), infrastructure, system workflow, clinical content, people (diverse roles), organization (ecosystem, service workflow, internal and external regulations), and financing (social security agency on health and independent). We used the Human-Organization- Technology Fit and Sociotechnical System approaches for analysis. The study suggests implications for future implementation and advocates for broader participant involvement, information technology (IT) studies for system development, and longitudinal evaluations to assess the impact on elderly health outcomes.
{"title":"Assessing Telemedicine Demand and Viability in Indonesian Geriatric Clinics: A Comprehensive HOT FIT and Sociotechnical Analysis","authors":"Dewi Shinta Kemala Sari, N. Lipoeto, Hafni Bachtiar, Indra Catri, Nina Kemala Sari, Rima Semiarty","doi":"10.2174/0118746098302999240522092726","DOIUrl":"https://doi.org/10.2174/0118746098302999240522092726","url":null,"abstract":"\u0000\u0000The growing elderly population in Indonesia presents challenges for the\u0000healthcare system, prompting the exploration of telemedicine as a solution. However, its effective\u0000implementation in Indonesia faces obstacles.\u0000\u0000\u0000\u0000This research aimed to develop a comprehensive geriatric telemedicine framework in Padang\u0000City by studying multiple stakeholders. We employed qualitative methods, including in-\u0000-depth interviews, across two hospitals, a Health Office, and a Community Health Center, involving\u000018 elderly participants.\u0000\u0000\u0000\u0000The study identified ten key dimensions for geriatric telemedicine services: technology,\u0000Human-Computer Interface (HCI), infrastructure, system workflow, clinical content, people (diverse\u0000roles), organization (ecosystem, service workflow, internal and external regulations), and financing\u0000(social security agency on health and independent). We used the Human-Organization-\u0000Technology Fit and Sociotechnical System approaches for analysis.\u0000\u0000\u0000\u0000The study suggests implications for future implementation and advocates for broader\u0000participant involvement, information technology (IT) studies for system development, and longitudinal\u0000evaluations to assess the impact on elderly health outcomes.\u0000","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"49 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141353461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-12DOI: 10.2174/0118746098315667240606052523
M. Atayik, Erdem Atasever, Şeydanur Turgut, U. Çakatay
Aging-related alteration of mitochondrial morphology, impairment in metabolic capacity, bioenergetics, and biogenesis are closely associated with loss of muscle mass and function. Mitochondrial Reactive Oxygen Species (ROS) stimulate muscular redox signaling mechanisms. Bioenergetic integrity of mitochondria and redox signaling dynamics deteriorates in aged skeletal muscle. Mitochondrial bioenergetic impairment leads to excessive ROS levels and induces the generation of defective mitochondria. Higher ROS levels may induce senescence or apoptosis. It is not a resolved issue that mitochondrial dysfunction is either the sole reason or a consequence of muscle loss (or both). However, Increasing evidence emphasizes that dysregulated mitochondrial redox signaling has a central role in age-related muscle loss. Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates redox signaling pathways with the expression of antioxidant genes. As the aberrant redox signaling mechanisms in aging skeletal muscle become clearer, new natural and synthetic Nrf2-modulating substances and integrated daily physical activity alternatives are coming into view for preventing muscle loss in the elderly. A comprehensive understanding of the relationship between redox signaling pathways and age-related sarcopenia can help us to prevent sarcopenia and its frailty effects with an optimized exercise program as an innovative non-pharmacological therapeutic approach. A further aspect is necessary to consider both individualized physical training options and alternative Nrf2 signaling modulators. Ameliorating the redox signaling with physical activity and pharmacological interventions may help to prevent sarcopenia and its frailty effects.
{"title":"Aging-associated Aberrant Mitochondrial Redox Signaling, Physical\u0000Activity, and Sarcopenia","authors":"M. Atayik, Erdem Atasever, Şeydanur Turgut, U. Çakatay","doi":"10.2174/0118746098315667240606052523","DOIUrl":"https://doi.org/10.2174/0118746098315667240606052523","url":null,"abstract":"\u0000\u0000Aging-related alteration of mitochondrial morphology, impairment in metabolic capacity,\u0000bioenergetics, and biogenesis are closely associated with loss of muscle mass and function. Mitochondrial\u0000Reactive Oxygen Species (ROS) stimulate muscular redox signaling mechanisms.\u0000Bioenergetic integrity of mitochondria and redox signaling dynamics deteriorates in aged skeletal\u0000muscle. Mitochondrial bioenergetic impairment leads to excessive ROS levels and induces the generation\u0000of defective mitochondria. Higher ROS levels may induce senescence or apoptosis. It is\u0000not a resolved issue that mitochondrial dysfunction is either the sole reason or a consequence of\u0000muscle loss (or both). However, Increasing evidence emphasizes that dysregulated mitochondrial\u0000redox signaling has a central role in age-related muscle loss. Nuclear factor erythroid 2-related factor\u00002 (Nrf2) regulates redox signaling pathways with the expression of antioxidant genes. As the\u0000aberrant redox signaling mechanisms in aging skeletal muscle become clearer, new natural and\u0000synthetic Nrf2-modulating substances and integrated daily physical activity alternatives are coming\u0000into view for preventing muscle loss in the elderly. A comprehensive understanding of the relationship\u0000between redox signaling pathways and age-related sarcopenia can help us to prevent sarcopenia\u0000and its frailty effects with an optimized exercise program as an innovative non-pharmacological\u0000therapeutic approach. A further aspect is necessary to consider both individualized physical\u0000training options and alternative Nrf2 signaling modulators. Ameliorating the redox signaling\u0000with physical activity and pharmacological interventions may help to prevent sarcopenia and its\u0000frailty effects.\u0000","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"93 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141352546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-06DOI: 10.2174/0118746098294208240429091631
Nooreen, Fariha Summayya, Prany Wal, A. Wal, A. Rai, Sudeep Tandon
Acute disseminated encephalomyelitis (ADEM) is a neural and immune-related disorder that occurs when the cerebrospinal system is damaged by extensive swelling. Although manifestation is possible regardless of age, adolescents have a greater probability. The purpose of the present manuscript is to provide recent advancements and enhance knowledge of the disease. The literature search on etiology, pathophysiology, diagnosis and treatment was carried out using the online databases of SciFinder, Medline, Pubmed, GoogleScholar, Scopus, etc. Although the cause of ADEM remains unclear, it is believed to be caused by inflammation in those with a genetic sensitivity to environmental stimulation. When people have altered levels of awareness or multifocal neurological abnormalities, ADEM is a possibility as a diagnosis. The diagnosis of ADEM is dependent on a combination of clinical and radiologic symptoms, whereas the exclusion of illnesses mimics ADEM; there is no one test that can establish the diagnosis. The inflammation in a child's brain and spinal cord is treated with medication. Prednisone is occasionally given to youngsters for a brief amount of time. Most children with ADEM improve with high doses of methylprednisolone. Cyclophosphamide is needed by individuals with hypothermia. Most investigations show that 50%- 75% of individuals completely recover between the first and sixth month of their condition.
{"title":"An Insight into Acute Disseminated Encephalomyelitis","authors":"Nooreen, Fariha Summayya, Prany Wal, A. Wal, A. Rai, Sudeep Tandon","doi":"10.2174/0118746098294208240429091631","DOIUrl":"https://doi.org/10.2174/0118746098294208240429091631","url":null,"abstract":"\u0000\u0000Acute disseminated encephalomyelitis (ADEM) is a neural and immune-related disorder that occurs when the cerebrospinal system is damaged by extensive swelling. Although manifestation is possible regardless of age, adolescents have a greater probability.\u0000The purpose of the present manuscript is to provide recent advancements and enhance\u0000knowledge of the disease.\u0000\u0000\u0000\u0000The literature search on etiology, pathophysiology, diagnosis and treatment was carried\u0000out using the online databases of SciFinder, Medline, Pubmed, GoogleScholar, Scopus, etc.\u0000\u0000\u0000\u0000Although the cause of ADEM remains unclear, it is believed to be caused by inflammation in those with a genetic sensitivity to environmental stimulation. When people have altered\u0000levels of awareness or multifocal neurological abnormalities, ADEM is a possibility as a diagnosis. The diagnosis of ADEM is dependent on a combination of clinical and radiologic symptoms,\u0000whereas the exclusion of illnesses mimics ADEM; there is no one test that can establish the diagnosis. The inflammation in a child's brain and spinal cord is treated with medication. Prednisone is occasionally given to youngsters for a brief amount of time.\u0000\u0000\u0000\u0000Most children with ADEM improve with high doses of methylprednisolone. Cyclophosphamide is needed by individuals with hypothermia. Most investigations show that 50%-\u000075% of individuals completely recover between the first and sixth month of their condition.\u0000","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"5 5‐6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141381472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-06DOI: 10.2174/0118746098308597240527114223
D. Linhares, Giullio César Pereira Salustiano Mallen da Silva Silva, Alex Santos Meireles, B. G. Linhares, Luciano Lima dos Santos, Lilliany de Souza Cordeiro, Claudio Joaquim Borba-Pinheiro, R. G. de Souza Vale
Physical exercise can take on a multivariate form, including combat sports, specifically Taekwondo, a Korean sport characterized by strikes involving the hands and feet. This sport has been gaining popularity worldwide in recent years and is being practiced by diverse populations, including the older women. This study aimed to investigate the effects of Taekwondo training on self-esteem and body image in older women with low bone mineral density (BMD). This is an experimental research with a two-group design, where assessments were conducted pre- and post during a 12-week intervention period. The sample consisted of 27 inexperienced older women in taekwondo practice, aged between 60 and 70 years, randomly distributed into the experimental group (n=14) and Control Group (n=13). BMD, self-esteem, and body image were assessed. For the evaluation of self-esteem, the Rosenberg Self-Esteem Scale (RSES) was utilized. For the evaluation of body images, the body image questionnaire was administered. The results showed that the practice of taekwondo improved (p<0.001) body image in the variables, including physical condition, body skills, and health, while the variable appearance showed no difference (p=0.581). The results of this experimental study indicate an improvement in the self-esteem and body image of older individuals practicing Taekwondo.
{"title":"Self-Esteem and Body Image in Older Women Practicing Taekwondo with\u0000Low Bone Density: A Randomized Clinical Trial","authors":"D. Linhares, Giullio César Pereira Salustiano Mallen da Silva Silva, Alex Santos Meireles, B. G. Linhares, Luciano Lima dos Santos, Lilliany de Souza Cordeiro, Claudio Joaquim Borba-Pinheiro, R. G. de Souza Vale","doi":"10.2174/0118746098308597240527114223","DOIUrl":"https://doi.org/10.2174/0118746098308597240527114223","url":null,"abstract":"\u0000\u0000Physical exercise can take on a multivariate form, including combat\u0000sports, specifically Taekwondo, a Korean sport characterized by strikes involving the hands and\u0000feet. This sport has been gaining popularity worldwide in recent years and is being practiced by diverse populations, including the older women.\u0000\u0000\u0000\u0000This study aimed to investigate the effects of Taekwondo training on self-esteem and\u0000body image in older women with low bone mineral density (BMD).\u0000\u0000\u0000\u0000This is an experimental research with a two-group design, where assessments were conducted pre- and post during a 12-week intervention period. The sample consisted of 27 inexperienced older women in taekwondo practice, aged between 60 and 70 years, randomly distributed into the experimental group (n=14) and Control Group (n=13). BMD, self-esteem, and body image\u0000were assessed. For the evaluation of self-esteem, the Rosenberg Self-Esteem Scale (RSES) was utilized. For the evaluation of body images, the body image questionnaire was administered.\u0000\u0000\u0000\u0000The results showed that the practice of taekwondo improved (p<0.001) body image in\u0000the variables, including physical condition, body skills, and health, while the variable appearance\u0000showed no difference (p=0.581).\u0000\u0000\u0000\u0000The results of this experimental study indicate an improvement in the self-esteem\u0000and body image of older individuals practicing Taekwondo.\u0000","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"24 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141380118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-17DOI: 10.2174/0118746098297063240409070531
Zeynep Gümüş Demir, Mahmut Yılmaz
INTRODUCTION The purpose of this study is to compare the loneliness, psychological well- being, depression, and social participation of elderly people living in Turkish society between rural and urban areas. The sample group of the study, in which a correlational survey model was used, consisted of 610 elderly adults. METHOD The study population consists of two groups: the first group consists of individuals over 65 years of age living in the city (Istanbul) (n= 291), and the second group consists of individuals over 65 years of age living in rural areas (rural areas of Ordu) (n= 319). Socio-demographic Information Form, Loneliness in the Elderly Scale, Geriatric Depression Scale, Psychological Well-Being in the Elderly Scale, and Social Inclusion Scale were applied online. Statistical analyses of the study were conducted using SPSS 27.00, and the Independent Samples t-test and ANOVA test were used. RESULTS According to the findings of this study, statistically significant results were found in psychological well-being, social inclusion, social relations, loneliness and depression, and place of residence. It was observed that the social isolation and social acceptance levels of those living in urban areas were higher than those living in rural areas. Social, loneliness, and depression scores of those living in the village/town were found to be higher than those living in the city centre. Furthermore, the social relationship scores of those living in the village/town were found to be higher than those living in the city centre. CONCLUSION The increasing elderly population worldwide has become an issue that requires global measures. Place of residence is one of the factors thought to affect older people's health and well- being. It is thought that the study data will contribute to new policies that will ensure the protection and promotion of elderly health and those working in this field. In addition, the study, which provides information about Turkish culture, will also enable intercultural comparisons.
{"title":"Loneliness, Psychological Well-being, Depression, and Social Participation in the Older Persons: Rural and Urban Differences.","authors":"Zeynep Gümüş Demir, Mahmut Yılmaz","doi":"10.2174/0118746098297063240409070531","DOIUrl":"https://doi.org/10.2174/0118746098297063240409070531","url":null,"abstract":"INTRODUCTION\u0000The purpose of this study is to compare the loneliness, psychological well- being, depression, and social participation of elderly people living in Turkish society between rural and urban areas. The sample group of the study, in which a correlational survey model was used, consisted of 610 elderly adults.\u0000\u0000\u0000METHOD\u0000The study population consists of two groups: the first group consists of individuals over 65 years of age living in the city (Istanbul) (n= 291), and the second group consists of individuals over 65 years of age living in rural areas (rural areas of Ordu) (n= 319). Socio-demographic Information Form, Loneliness in the Elderly Scale, Geriatric Depression Scale, Psychological Well-Being in the Elderly Scale, and Social Inclusion Scale were applied online. Statistical analyses of the study were conducted using SPSS 27.00, and the Independent Samples t-test and ANOVA test were used.\u0000\u0000\u0000RESULTS\u0000According to the findings of this study, statistically significant results were found in psychological well-being, social inclusion, social relations, loneliness and depression, and place of residence. It was observed that the social isolation and social acceptance levels of those living in urban areas were higher than those living in rural areas. Social, loneliness, and depression scores of those living in the village/town were found to be higher than those living in the city centre. Furthermore, the social relationship scores of those living in the village/town were found to be higher than those living in the city centre.\u0000\u0000\u0000CONCLUSION\u0000The increasing elderly population worldwide has become an issue that requires global measures. Place of residence is one of the factors thought to affect older people's health and well- being. It is thought that the study data will contribute to new policies that will ensure the protection and promotion of elderly health and those working in this field. In addition, the study, which provides information about Turkish culture, will also enable intercultural comparisons.","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"169 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140693521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-09DOI: 10.2174/0118746098301226240402051508
Shefilyn Widjaja, R. Antarianto, N. Hardiany
Ageing is the most significant risk factor for a number of non-communicable diseases, manifesting as cognitive, metabolic, and cardiovascular diseases. Although multifactorial, mitochondrial dysfunction and oxidative stress have been proposed to be the driving forces of ageing. Peroxisome proliferator-activated receptor γ coactivator α (PGC-1α) is a transcriptional coactivator central to various metabolic functions, of which mitochondrial biogenesis is the most prominent function. Inducible by various stimuli, including nutrient limitations, PGC-1α is a molecule of interest in the maintenance of mitochondrial function and, therefore, the prevention of degenerative diseases. This review involves a literature search for articles retrieved from PubMed using PGC-1α, ageing, and dietary restriction as keywords. Dietary restriction has been shown to promote tissue-specific PGC-1α expression. Both dietary restriction and PGC-1α upregulation have been shown to prolong the lifespans of both lower and higher-level organisms; the incidence of non-communicable diseases also decreased in fasting mammals. In conclusion, dietary interventions may delay ageing by regulating healthy mitochondria in various organs, presenting the possibility of a new primary prevention for many age-related diseases.
{"title":"Effects of Dietary Restriction on PGC-1α Regulation in the Development of Age-associated Diseases.","authors":"Shefilyn Widjaja, R. Antarianto, N. Hardiany","doi":"10.2174/0118746098301226240402051508","DOIUrl":"https://doi.org/10.2174/0118746098301226240402051508","url":null,"abstract":"Ageing is the most significant risk factor for a number of non-communicable diseases, manifesting as cognitive, metabolic, and cardiovascular diseases. Although multifactorial, mitochondrial dysfunction and oxidative stress have been proposed to be the driving forces of ageing. Peroxisome proliferator-activated receptor γ coactivator α (PGC-1α) is a transcriptional coactivator central to various metabolic functions, of which mitochondrial biogenesis is the most prominent function. Inducible by various stimuli, including nutrient limitations, PGC-1α is a molecule of interest in the maintenance of mitochondrial function and, therefore, the prevention of degenerative diseases. This review involves a literature search for articles retrieved from PubMed using PGC-1α, ageing, and dietary restriction as keywords. Dietary restriction has been shown to promote tissue-specific PGC-1α expression. Both dietary restriction and PGC-1α upregulation have been shown to prolong the lifespans of both lower and higher-level organisms; the incidence of non-communicable diseases also decreased in fasting mammals. In conclusion, dietary interventions may delay ageing by regulating healthy mitochondria in various organs, presenting the possibility of a new primary prevention for many age-related diseases.","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140721045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.2174/187460981701240229094013
S. Pathak, Antara Banerjee
{"title":"RNA-based Therapies for Aging and Cancer, What Known so Far?","authors":"S. Pathak, Antara Banerjee","doi":"10.2174/187460981701240229094013","DOIUrl":"https://doi.org/10.2174/187460981701240229094013","url":null,"abstract":"<jats:sec>\u0000<jats:title />\u0000<jats:p />\u0000</jats:sec>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"105 51","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140090243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.2174/187460981701240229093409
S. L. Schmidt
{"title":"Meet the Editor in Chief","authors":"S. L. Schmidt","doi":"10.2174/187460981701240229093409","DOIUrl":"https://doi.org/10.2174/187460981701240229093409","url":null,"abstract":"<jats:sec>\u0000<jats:title />\u0000<jats:p />\u0000</jats:sec>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"106 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140089960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-22DOI: 10.2174/0118746098287130240212085507
Deepti Dwevedi, Ankur Srivastava
The natural process of skin aging is influenced by a variety of factors, including oxidative stress, inflammation, collagen degradation, and UV radiation exposure. The potential of polyphenols in controlling skin aging has been the subject of much investigation throughout the years. Due to their complex molecular pathways, polyphenols, a broad class of bioactive substances present in large quantities in plants, have emerged as attractive candidates for skin anti-aging therapies. This review aims to provide a comprehensive overview of the molecular mechanisms through which polyphenols exert their anti-aging effects on the skin. Various chemical mechanisms contribute to reducing skin aging signs and maintaining a vibrant appearance. These mechanisms include UV protection, moisturization, hydration, stimulation of collagen synthesis, antioxidant activity, and anti-inflammatory actions. These mechanisms work together to reduce signs of aging and keep the skin looking youthful. Polyphenols, with their antioxidant properties, are particularly noteworthy. They can neutralize free radicals, lessening oxidative stress that might otherwise cause collagen breakdown and DNA damage. The anti-inflammatory effects of polyphenols are explored, focusing on their ability to suppress pro-inflammatory cytokines and enzymes, thereby alleviating inflammation and its detrimental effects on the skin. Understanding these mechanisms can guide future research and development, leading to the development of innovative polyphenol-based strategies for maintaining healthy skin.
皮肤的自然老化过程受到多种因素的影响，包括氧化压力、炎症、胶原蛋白降解和紫外线照射。多年来，人们一直在研究多酚在控制皮肤老化方面的潜力。多酚是植物中大量存在的一类生物活性物质，由于其复杂的分子途径，多酚已成为具有吸引力的皮肤抗衰老候选疗法。本综述旨在全面概述多酚对皮肤产生抗衰老作用的分子机制。各种化学机制有助于减少皮肤老化迹象，保持皮肤的活力。这些机制包括紫外线防护、保湿、补水、刺激胶原蛋白合成、抗氧化和抗炎作用。这些机制共同作用，减少老化迹象，保持肌肤年轻。多酚的抗氧化特性尤其值得一提。它们可以中和自由基，减轻氧化压力，否则可能会导致胶原蛋白分解和 DNA 损伤。多酚的抗炎作用也得到了探讨，重点是它们抑制促炎细胞因子和酶的能力，从而减轻炎症及其对皮肤的有害影响。了解这些机理可以指导未来的研究和开发工作，从而开发出基于多酚的创新策略来保持皮肤健康。
{"title":"Molecular Mechanisms of Polyphenols in Management of Skin Aging","authors":"Deepti Dwevedi, Ankur Srivastava","doi":"10.2174/0118746098287130240212085507","DOIUrl":"https://doi.org/10.2174/0118746098287130240212085507","url":null,"abstract":"\u0000\u0000The natural process of skin aging is influenced by a variety of factors, including oxidative\u0000stress, inflammation, collagen degradation, and UV radiation exposure. The potential of polyphenols\u0000in controlling skin aging has been the subject of much investigation throughout the\u0000years. Due to their complex molecular pathways, polyphenols, a broad class of bioactive substances\u0000present in large quantities in plants, have emerged as attractive candidates for skin anti-aging\u0000therapies. This review aims to provide a comprehensive overview of the molecular mechanisms\u0000through which polyphenols exert their anti-aging effects on the skin. Various chemical\u0000mechanisms contribute to reducing skin aging signs and maintaining a vibrant appearance. These\u0000mechanisms include UV protection, moisturization, hydration, stimulation of collagen synthesis,\u0000antioxidant activity, and anti-inflammatory actions. These mechanisms work together to reduce\u0000signs of aging and keep the skin looking youthful. Polyphenols, with their antioxidant properties,\u0000are particularly noteworthy. They can neutralize free radicals, lessening oxidative stress that might\u0000otherwise cause collagen breakdown and DNA damage. The anti-inflammatory effects of polyphenols\u0000are explored, focusing on their ability to suppress pro-inflammatory cytokines and enzymes,\u0000thereby alleviating inflammation and its detrimental effects on the skin. Understanding these\u0000mechanisms can guide future research and development, leading to the development of innovative\u0000polyphenol-based strategies for maintaining healthy skin.\u0000","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":"10 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140441563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号