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Evaluating the Balancing Ability of Older Adults with Diabetes Mellitus Using the Multi-directional Reach Test. 利用多向前移测试评估糖尿病老年人的平衡能力
Q3 Medicine Pub Date : 2024-01-01 DOI: 10.2174/0118746098253144231024052312
Patchareeya Amput, Sirima Wongphon, Patcharin Phrompao

Background: The incidence of elderly people experiencing falls is currently increasing, which results in serious medical issues, such as fear of falling, limited physical activity, disability, and bone fractures, especially hip fractures. This study aimed to investigate balancing ability using a multi-directional reach test (MDRT) in older adults with and without diabetes mellitus.

Methods: 72 older adults with and without diabetes mellitus were recruited, and divided into two groups, including older adults without diabetes mellitus (n = 36) and older adults with diabetes mellitus (n = 36). All subjects completed all directions of the MDRT.

Results: There were no significant differences in MDRT scores in all directions between the two groups (p>0.05). Both groups achieved the highest MDRT scores in the forward direction. In contrast, the two groups had the lowest scores of MDRT in a backward direction. Furthermore, older adults with diabetes mellitus had lower MDRT scores in all directions than older adults without diabetes mellitus.

Conclusion: The current study indicated that MDRT could be used to investigate the ability of balance in individuals with diabetes mellitus.

背景:目前,老年人跌倒的发生率越来越高,这导致了严重的医疗问题,如害怕跌倒、体力活动受限、残疾和骨折,尤其是髋部骨折。方法:招募 72 名患有和未患有糖尿病的老年人,将其分为两组,包括未患有糖尿病的老年人(36 人)和患有糖尿病的老年人(36 人)。所有受试者都完成了MDRT的所有方向:结果:两组受试者在所有方向的 MDRT 分数均无明显差异(P>0.05)。两组受试者在前进方向的 MDRT 分数都最高。相反,两组在后向的 MDRT 分数最低。此外,患有糖尿病的老年人在所有方向上的 MDRT 分数都低于未患糖尿病的老年人:本研究表明,MDRT 可用于调查糖尿病患者的平衡能力。
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引用次数: 0
STOPP-START Criteria Used to Identify the Elderly Population Prone to Potentially Inadequate Prescribing in a Colombian Cohort. STOPP-START 标准用于识别哥伦比亚队列中可能出现处方不当的老年人群。
Q3 Medicine Pub Date : 2024-01-01 DOI: 10.2174/0118746098274486231227101704
Loren Zambrano, Rosa-Helena Bustos, Edgar Beltran, Daniel Gomez, Sara Arias, Wilson Briceño

Background: Elderly people have multiple comorbidities that often require treatment with multiple medications. Having strategies to lessen the risks associated with pharmacological interactions and potentially inadequate prescribing (PIP) is of major importance. The STOPP- START criteria are useful in identifying PIP along with other tools, such as LASA (look alike/sound alike) drugs and high-risk medications (HRM).

Objective: We aimed to clinically and sociodemographically characterize the population with PIP according to the STOPP-START criteria in hospitalized elderly patients over 6 months in a third-level hospital in Colombia, South America. We also aimed to calculate the prevalence of PIP, LASA drugs and HRM and to identify other problems related with medication. Finally, we proposed an algorithm for the identification of PIP in this population.

Methods and materials: This was a descriptive, cross-sectional study in hospitalized patients older than 60 years during the first semester of 2021 to identify PIP according to STOPP- START criteria. An analysis of clinical and sociodemographic variables was conducted, as well as the construction of an algorithm to identify PIP in the elderly in a semiautomated way. Data were collected and analyzed using the software SPSS 2021, using descriptive statistics and measures of central tendency.

Results: The prevalence of PIP in the study population was 25%. Furthermore, 60% of patients had one problem related to medication, and 27% used at least one LASA drug or HRM.

Conclusion: This study allows one to characterize, for the first time, the Colombian population prone to PIP, as well as the construction of an algorithm that identifies PIP in a semiautomated way.

背景:老年人有多种并发症,通常需要使用多种药物进行治疗。如何降低药物相互作用和潜在处方不当(PIP)带来的风险至关重要。STOPP- START 标准以及其他工具,如 LASA(外观相似/声音相似)药物和高风险药物 (HRM),有助于识别 PIP:我们的目的是根据 STOPP-START 标准,从临床和社会人口学角度分析南美洲哥伦比亚一家三级医院 6 个月以上住院老年患者中 PIP 患者的特征。我们还旨在计算 PIP、LASA 药物和 HRM 的患病率,并找出与药物治疗有关的其他问题。最后,我们提出了一种在该人群中识别 PIP 的算法:这是一项描述性横断面研究,研究对象是 2021 年上半年住院的 60 岁以上患者,目的是根据 STOPP- START 标准识别 PIP。对临床和社会人口学变量进行了分析,并构建了一种半自动化识别老年人 PIP 的算法。数据的收集和分析采用了 SPSS 2021 软件,使用了描述性统计和中心倾向测量:研究人群中 PIP 的发病率为 25%。此外,60%的患者有一个与药物治疗相关的问题,27%的患者至少使用一种LASA药物或HRM:本研究首次描述了哥伦比亚易患 PIP 的人群特征,并构建了一种半自动识别 PIP 的算法。
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引用次数: 0
N-Stearoylethanolamine Exerts Cardioprotective Effects in Old Rats. N-硬脂酰乙醇胺对老龄大鼠的心脏保护作用
Q3 Medicine Pub Date : 2024-01-01 DOI: 10.2174/0118746098275323231226073348
Halyna Kosiakova, Andrii Berdyshev, Tetyana Horid'ko, Olena Meged, Vitaliy Klimashevsky, Roza Matsokha, Oksana Tkachenko, Valentina Asmolkova, Tetyana Kvitnitskaya-Ryzhova, Serhii Luhovskyi, Pavlo Klymenko, Nadiya Hula

Background: Aging is associated with the slowing down of metabolic processes, diminished physiological processes, changes in hormonal activity and increasing exposure to oxidative stress factors and chronic inflammation. The endocannabinoid system (ECS) is a major signaling network that plays a pro-homeostatic role in the central and peripheral organs of the human body. A class of minor lipids, N-acylethanolamines (NAEs), which do not activate cannabinoid receptors, except for anandamide, but can potentiate the action of endocannabinoids and have a wide spectrum of biological activity and significant adaptogenic potential, belongs to ECS. The results of different studies over the past decades have established the protective effect of NAE on many pathological conditions.

Objective: This study aimed to investigate the cardioprotective effects of C18:0 NAE- N-stearoylethanolamine (NSE) in aged rats. In this study, we focused on investigating the effects of C18:0 NAE- N-stearoylethanolamine (NSE) on the intensity of oxidative/ nitrosative stress, antioxidant potential, lipoprotein profile and inflammation markers of blood plasma, phospholipid composition and age-related morphological changes of old rat heart tissues.

Methods: The study was conducted on Sprague Dawley male laboratory rats. The three groups of rats were involved in the study design. The first group consisted of young rats aged 4 months (n=10). The second (n=10) and third (n=10) groups included old rats aged of 18 months. Rats from the third group were administered a per os aqueous suspension of NSE at a dose of 50 mg/kg of body weight daily for 10 days. All groups of rats were kept on a standard vivarium diet. The blood plasma, serum, and heart of rats were used for biochemical and histological analysis.

Results: The cardioprotective effect of N-stearoylethanolamine in old rats was established, which was expressed in the normalization of the antioxidant system condition and the level of proinflammatory cytokines, positive modulation of blood plasma and lipoprotein profile, normalization of heart tissue lipid composition, and significant reduction in age-related myocardium morphological changes.

Conclusion: The revealed effects of N-stearoylethanolamine can become the basis for developing a new drug for use in complex therapy to improve the quality of life of older people.

背景:衰老与新陈代谢过程减慢、生理过程减弱、荷尔蒙活动变化以及氧化应激因素和慢性炎症暴露增加有关。内源性大麻素系统(ECS)是一个重要的信号网络,在人体的中枢和外周器官中发挥着促进平衡的作用。N-acylethanolamines (NAEs)是一类次要脂质,属于 ECS 的一种,除 anandamide 外,NAEs 不会激活大麻素受体,但可以增强内源性大麻素的作用,具有广泛的生物活性和显著的适应潜力。目的:本研究旨在探讨 C18:0 NAE-Nstearoylethanolamine(NSE)对老年大鼠心脏的保护作用:本研究主要探讨了 C18:0 NAE-Nstearoylethanolamine(NSE)对老年大鼠血浆氧化/亚硝基应激强度、抗氧化潜能、脂蛋白谱和炎症标志物、磷脂组成以及与年龄相关的心脏组织形态学变化的影响:研究对象为 Sprague Dawley 雄性实验鼠。研究设计了三组大鼠。第一组是 4 个月大的幼鼠(n=10)。第二组(10 只)和第三组(10 只)包括 18 个月大的老老鼠。第三组的大鼠每天按体重 50 毫克/千克的剂量服用 NSE 水悬液,连续服用 10 天。所有组别大鼠均以标准饲养室饮食饲养。对大鼠的血浆、血清和心脏进行生化和组织学分析:结果:N-硬脂酰乙醇胺对老年大鼠心脏有保护作用,表现在抗氧化系统状况和促炎细胞因子水平正常化,血浆和脂蛋白谱有积极调节作用,心脏组织脂质成分正常化,与年龄相关的心肌形态学变化显著减少:结论:N-硬脂酰乙醇胺所揭示的作用可作为开发用于复合疗法的新药的基础,以改善老年人的生活质量。
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引用次数: 0
Pre-operative Neo-adjuvant Chemotherapy Related miRNAs as Key Regulators and Therapeutic Targets in Colorectal Cancer. 作为结直肠癌关键调控因子和治疗靶点的术前新辅助化疗相关 miRNAs
Q3 Medicine Pub Date : 2024-01-01 DOI: 10.2174/1874609816666230816152744
Orcun Yalav, Ozge Sonmezler, Kivilcim Eren Erdogan, Ahmet Rencuzogullari, Figen Doran, Atil Bisgin, Ibrahim Boga

Background: In colorectal cancer, the investigation of cancer pathogenesis and the determination of the relevant gene and gene pathways is particularly important to provide a basis for treatment-oriented studies. miRNAs which affect gene regulation in the molecular pathogenesis of cancer, have an active role in carcinogenesis. In the literature, miRNA expression levels have been associated with metastasis and prognosis in different cancers.

Objective: In our study, expression profiling of miRNAs involved in oncogenic and apoptotic pathways in patients with locally advanced colorectal cancer receiving neoadjuvant therapy was performed.

Methods: miRNAs were isolated from three different FFPE tissue samples taken at different times of the same patient (tumor tissue taken at the time of diagnosis, normal tissue samples, and after neoadjuvant therapy). The expression analysis of 84 miRNAs determined by PCR array (Fluidigm, USA) and mediated meta-analysis was performed comparatively to each study and non-cancerous control group. Evaluations were performed with ΔΔCT calculations.

Results: As a result of the miRNA PCR array study, in addition to differences were observed in miRNA expression between control and study groups. The potential biomarkers which were hsamiR- 215-5p, hsa-miR-9-59, hsa-miR-193a-5p, hsa-miR-206, hsa-miR-1, hsa-miR-96-5p have been detected for possible treatment resistance, prognosis and predispositions to cancers.

Conclusion: In patients with colorectal cancer, miRNA expression in the tumoral regions before and after neoadjuvant therapy has represented a variable pattern. It has been shown that miRNA studies can be used to predict the clinical course and response to treatment with differences in expression levels. It has been concluded that specific miRNAs may be candidate biomarkers for colorectal cancer.

.

背景:miRNA影响癌症分子发病机制中的基因调控,在致癌过程中发挥着积极作用。在文献中,miRNA 的表达水平与不同癌症的转移和预后有关:我们的研究对接受新辅助治疗的局部晚期结直肠癌患者中参与致癌和凋亡通路的 miRNA 进行了表达谱分析。方法:从同一患者不同时期的三个不同 FFPE 组织样本(诊断时的肿瘤组织、正常组织样本和新辅助治疗后的组织样本)中分离出 miRNA。通过 PCR 阵列(Fluidigm,美国)测定了 84 个 miRNA 的表达,并对每项研究和非癌症对照组进行了介导荟萃分析。评价采用ΔΔCT计算:miRNA PCR 阵列研究结果显示,对照组和研究组之间的 miRNA 表达存在差异。结果:miRNA PCR 阵列研究的结果显示,对照组和研究组的 miRNA 表达量存在差异,还发现了一些潜在的生物标志物,如 hsamiR- 215-5p、hsa-miR-9-59、hsa-miR-193a-5p、hsa-miR-206、hsa-miR-1、hsa-miR-96-5p,这些标志物可能与癌症的耐药性、预后和易感性有关:结论:在结直肠癌患者中,新辅助治疗前后肿瘤区域的 miRNA 表达呈现出不同的模式。研究表明,miRNA 研究可用于预测临床病程和对不同表达水平治疗的反应。研究认为,特定的 miRNA 可能是结直肠癌的候选生物标志物。
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引用次数: 0
Depression Symptoms Amongst Older Brazilian and Chinese Women Submitted to Different Social Distancing Measures Rigidness During COVID-19 Outbreak. 新冠肺炎疫情期间,巴西和中国老年妇女的抑郁症状表现为不同的社交距离措施。
Q3 Medicine Pub Date : 2024-01-01 DOI: 10.2174/1874609816666230816152105
Lucimere Bohn, Clarice Martins Lucena, André Pereira Dos Santos, Sitong Chen, Pedro Pugliesi Abdalla

Background: It is plausible that depression symptoms and disrupting sleep quality were differently affected according to the rigidity of social distancing during the COVID-19 outbreak.

Objective: To describe and compare depression symptoms and sleep quality amongst older Brazilian and Chinese women who were submitted to different social distancing measures (less rigid (Brazil) versus more rigid (China)).

Methods: This observational cross-sectional study assessed urban older women who underwent home confinement with less (Brazil; n=1015) or more (China; n=644) rigidity. Socio-demographic correlates, general health information, depression symptoms [Geriatric Depression Scale (GDS- 15)], and sleep quality [Pittsburgh Sleep Quality Index (PSQI)] were assessed through interviews.

Results: 1659 older women (66.74 ± 5.48 years old; 38.8% Chinese; 61.2% Brazilian) were included for analysis. 22% of Brazilians and 19.6% of Chinese women presented depression symptoms. The frequency of bad sleepers was 56.4% and 37.7% amongst Brazilian and Chinese older women, respectively. After adjusting for socio-demographic variables, general health status, and PSQI global score, Chinese women had a significantly higher score of depression symptoms (3.88 ± 0.13) compared to the Brazilians (3.26 ± 0.10; p < 0.001).

Conclusion: The frequency of poor sleep quality was very high regardless of the country. After adjusting for confounders and sleep quality, older Chinese women had a significantly superior score of depression symptoms exacerbating psychological distress by confinement rigidness.

背景:在新冠肺炎爆发期间,抑郁症状和睡眠质量紊乱可能会因社交距离的严格性而受到不同的影响。目的:描述和比较接受不同社交距离措施(不太严格的(巴西)和更严格的(中国))的巴西和中国老年女性的抑郁症状和睡眠质量。方法:这项观察性横断面研究评估了接受家庭分娩的城市老年女性,她们的僵硬程度较低(巴西;n=1015)或更高(中国;n=644)。通过访谈评估社会人口统计学相关性、一般健康信息、抑郁症状[老年抑郁量表(GDS15)]和睡眠质量[匹兹堡睡眠质量指数(PSQI)]。结果:1659名老年女性(66.74±5.48岁;38.8%为中国人;61.2%为巴西人)被纳入分析。22%的巴西人和19.6%的中国女性出现抑郁症状。巴西和中国老年女性睡眠不良的发生率分别为56.4%和37.7%。在调整了社会人口统计学变量、总体健康状况和PSQI全球评分后,中国女性的抑郁症状评分(3.88±0.13)明显高于巴西人(3.26±0.10;p<0.001)。结论:无论哪个国家,睡眠质量差的频率都很高。在对混杂因素和睡眠质量进行调整后,中国老年女性的得分明显更高。抑郁症症状因禁闭僵硬而加剧心理困扰。
{"title":"Depression Symptoms Amongst Older Brazilian and Chinese Women Submitted to Different Social Distancing Measures Rigidness During COVID-19 Outbreak.","authors":"Lucimere Bohn, Clarice Martins Lucena, André Pereira Dos Santos, Sitong Chen, Pedro Pugliesi Abdalla","doi":"10.2174/1874609816666230816152105","DOIUrl":"10.2174/1874609816666230816152105","url":null,"abstract":"<p><strong>Background: </strong>It is plausible that depression symptoms and disrupting sleep quality were differently affected according to the rigidity of social distancing during the COVID-19 outbreak.</p><p><strong>Objective: </strong>To describe and compare depression symptoms and sleep quality amongst older Brazilian and Chinese women who were submitted to different social distancing measures (less rigid (Brazil) versus more rigid (China)).</p><p><strong>Methods: </strong>This observational cross-sectional study assessed urban older women who underwent home confinement with less (Brazil; n=1015) or more (China; n=644) rigidity. Socio-demographic correlates, general health information, depression symptoms [Geriatric Depression Scale (GDS- 15)], and sleep quality [Pittsburgh Sleep Quality Index (PSQI)] were assessed through interviews.</p><p><strong>Results: </strong>1659 older women (66.74 ± 5.48 years old; 38.8% Chinese; 61.2% Brazilian) were included for analysis. 22% of Brazilians and 19.6% of Chinese women presented depression symptoms. The frequency of bad sleepers was 56.4% and 37.7% amongst Brazilian and Chinese older women, respectively. After adjusting for socio-demographic variables, general health status, and PSQI global score, Chinese women had a significantly higher score of depression symptoms (3.88 ± 0.13) compared to the Brazilians (3.26 ± 0.10; p < 0.001).</p><p><strong>Conclusion: </strong>The frequency of poor sleep quality was very high regardless of the country. After adjusting for confounders and sleep quality, older Chinese women had a significantly superior score of depression symptoms exacerbating psychological distress by confinement rigidness.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"85-92"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perturbation-based Balance Training in Adults Aged Above 55 Years with Chronic Low Back Pain: A Comparison of Effects of Water versus Land Medium - A Preliminary Randomized Trial. 对 55 岁以上患有慢性腰痛的成年人进行基于扰动的平衡训练:水媒与陆媒效果比较 - 初步随机试验。
Q3 Medicine Pub Date : 2024-01-01 DOI: 10.2174/0118746098254991231125143735
Ramprasad Muthukrishan, Fatima Mohammed Badr Ul Islam, Sukumar Shanmugam, Watson Arulsingh, Kumaraguruparan Gopal, Praveen Kumar Kandakurti, Sannasi Rajasekar, Gulshan Shahzadi Malik, Geovinson S G

Background: 'Rapid balance reaction' or 'perturbation' training is an emerging paradigm in elderly back pain rehabilitation due to its connection to postural stability.

Objective: This study aimed to inform the feasibility and practicality of perturbation-based balance training (PBT) using a stratification approach and to determine the effectiveness of land versus water-based PBT in elderly individuals with chronic low back pain (CLBP).

Methods: Elderly CLBP participants (n=24) received exercise interventions as per treatmentbased classification (TBC) and were randomly allotted into water-based perturbation exercises (WBPE, Mean age=63.0±2.6years, n=12) and land-based perturbation exercise group (LBPE, 62.3±2.6 years, n=12). Pain intensity, disability, scores of fear-avoidance beliefs, fall efficacy, and rate of perceived exertion (RPE) were assessed before and at the end of 6 weeks.

Results: WBPE group reported a significant reduction in pain score (median difference(MD)):2, p<0.03), fear avoidance behaviour for work (MD:9, p<0.01) and fear avoidance behaviour for physical activity (MD:10, p< 0.05), improved straight leg raise right (SLR) (MD:37.5°, p<0.05), and improved modified fall efficacy scores (MFES, MD:25, p<0.05) compared to the LBPE group at post-intervention. Within-group analysis in both groups revealed significant improvement in clinical outcomes except for fear-avoidance beliefs related to physical activity in the LBPE group. Subgroup analysis revealed that the high BMI elderly CLBP group of LBPE had significant improvements similar to the WBPE group except for scores of FABQ physical activity scores and SLR.

Conclusion: Possible key factors for future research are discussed in the realms of perturbation exercise in the elderly with CLBP.

背景:"快速平衡反应 "或 "扰动 "训练因其与姿势稳定性有关而成为老年腰痛康复的一种新兴模式:本研究旨在通过分层方法了解基于扰动的平衡训练(PBT)的可行性和实用性,并确定在患有慢性腰背痛(CLBP)的老年人中,陆基与水基PBT的有效性:老年慢性腰背痛患者(24 人)按照治疗分类法(TBC)接受运动干预,并随机分配到水上扰动运动组(WBPE,平均年龄=63.0±2.6 岁,12 人)和陆上扰动运动组(LBPE,62.3±2.6 岁,12 人)。在6周前和6周结束时,对疼痛强度、残疾程度、恐惧-回避信念评分、跌倒功效和感知用力率(RPE)进行评估:结果:WBPE 组的疼痛评分明显降低(中位数差异(MD):2,p):讨论了在患有慢性前列腺痛的老年人中进行扰动运动的未来研究的可能关键因素。
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引用次数: 0
Neuropsychiatric Symptoms are Related to Blood-biomarkers in Major Neurocognitive Disorders. 神经精神症状与主要神经认知障碍的血液生物标志物有关。
Q3 Medicine Pub Date : 2024-01-01 DOI: 10.2174/1874609816666230816090934
Inês Marques-Aleixo, Arnaldina Sampaio, Lucimére Bohn, Flavia Machado, Duarte Barros, Oscár Ribeiro, Joana Carvalho, José Magalhães

Background: Neuropsychiatric symptoms (NPS) are highly prevalent among individuals with major neurocognitive disorders (MNCD).

Objective: Here, we characterized blood biomarkers (metabolic, inflammatory, neurotrophic profiles and total antioxidant), body composition, physical fitness and quality of life (QoL) in individuals with MNCD according to NPS.

Methods: The sample comprised 34 older adults (71.4% women; 74.06±6.03 yrs, with MNCD diagnosis) categorized according to 50th percentile [Low (≤12) or High (≥13)] for NPS (Neuropsychiatric Inventory Questionnaire). Sociodemographic, clinical data, body composition, anthropometric, cognitive assessment (ADAS-Cog), physical fitness (Senior Fitness Test), QoL (QoL-Alzheimer's Disease scale) were evaluated, and blood samples were collected for biochemical analysis.

Results: Low compared to high NPS group showed higher levels of IL-6, IGF-1and neurotrophic zscore (composite of IGF-1, VEGF-1, BDNF). Additionally, low compared to high NPS group have higher QoL, aerobic fitness and upper body and lower body strength.

Conclusion: The severity of NPS seems to be related to modified neurotrophic and inflammatory outcomes, lower physical fitness, and poor QoL. Strategies to counteract NPS development may preserve the physical and mental health of individuals with MNCD.

.

背景:神经精神症状(NPS)在患有严重神经认知障碍(MNCD)的个体中非常普遍。目的:根据NPS,我们对MNCD患者的血液生物标志物(代谢、炎症、神经营养特征和总抗氧化剂)、身体成分、身体素质和生活质量(QoL)进行了表征。方法:样本包括34名老年人(71.4%为女性;74.06±6.03岁,诊断为MNCD),根据NPS(神经精神问卷)的第50百分位[低(≤12)或高(≥13)]进行分类。评估社会形态、临床数据、身体成分、人体测量、认知评估(ADAS-Cog)、体能(老年人体能测试)、生活质量(生活质量阿尔茨海默病量表),并采集血样进行生化分析。结果:与高NPS组相比,低NPS组显示出更高水平的IL-6、IGF-1和神经营养核心(IGF-1、VEGF-1、BDNF的复合物)。此外,与高NPS组相比,低NPS组具有更高的生活质量、有氧健身以及上半身和下半身力量。结论:NPS的严重程度似乎与改良的神经营养和炎症结果、较低的身体素质和较差的生活质量有关。对抗NPS发展的策略可以保护MNCD患者的身心健康。
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引用次数: 0
Blackcurrant Supplementation and Habitual Physical Activity Enhance Functional Capacity and Quality of Life in Previously Sedentary Older Women. 黑加仑补充剂和习惯性体育锻炼可提高以往久坐不动的老年妇女的功能能力和生活质量。
Q3 Medicine Pub Date : 2024-01-01 DOI: 10.2174/0118746098261936231223164430
Stefania Chatzopoulou, Eleftherios Dimitros, Marika Massaro, Antonio Cicchella, Athanasios Jamurtas, Evangelia Kouidi, Dimitrios Tsiptsios, Glen P Kenny, Antonia Kaltsatou

Background: Loss of functional capacity negatively impacts the quality of life in older adults.

Objective: This single-site randomized controlled study examined whether short- (one week) and long-term (three months) blackcurrant supplementations combined with habitual physical activity would improve functional capacity and quality of life in previously sedentary older women.

Methods: Thirty sedentary, healthy older women were randomly assigned to receive blackcurrant supplementation (400 mg of blackcurrant extract) (Polyphenol group, n=15; 74.2±10.0 years) or no supplementation (capsules of 400 mg of corn flour) (Placebo group, n=15; 72.8±8.7 years). Each group consumed two capsules daily for one week and three months, with a washout period of one week between the two phases. The polyphenol group was required to increase habitual activity levels. Participants underwent a functional capacity assessment consisting of a sixminute walk, sit-to-stand test, Berg balance scale measurement and quality of life evaluation with the Scale of Life Satisfaction Index (LSI) at the start, after one week, and after three months of supplementation.

Results: Walking distance and time to sit-to-stand improved by 2.5% (p=0.005) and 7.5% (p=0.005), respectively, after one week in the polyphenol group. After 3 months, walking distance in the six-minute walk test increased by 12.3% (p=0.001) while the time to sit-to-stand decreased by 16% (p=0.002) in the polyphenol compared to placebo group, respectively. No differences in Berg balance scale were observed. Quality of life, indexed by LSI, improved by 39% (p=0.001) in the polyphenol compared to the placebo group.

Conclusion: Blackcurrant supplementation, combined with habitual activity, may enhance functional capacity and quality of life in older women, offering a potential strategy to maintain independence. However, future studies should address longer durations to validate these findings.

背景:功能丧失对老年人的生活质量产生负面影响:功能丧失会对老年人的生活质量产生负面影响:这项单点随机对照研究考察了短期(一周)和长期(三个月)黑加仑补充剂与习惯性体育锻炼相结合是否会提高以前久坐不动的老年妇女的功能能力和生活质量:30名久坐不动的健康老年妇女被随机分配接受黑加仑补充剂(400毫克黑加仑提取物)(多酚组,n=15;74.2±10.0岁)或不接受补充剂(400毫克玉米粉胶囊)(安慰剂组,n=15;72.8±8.7岁)。每组每天服用两粒胶囊,分别服用一周和三个月,两个阶段之间有一周的冲洗期。多酚组需要增加惯常活动量。在开始服用时、服用一周后和服用三个月后,参加者接受了功能能力评估,包括六分钟步行、坐立测试、伯格平衡量表测量和生活质量满意度指数(LSI)评估:结果:多酚组的步行距离和坐立时间在一周后分别提高了 2.5%(p=0.005)和 7.5%(p=0.005)。3 个月后,与安慰剂相比,多酚组在六分钟步行测试中的步行距离增加了 12.3%(p=0.001),而坐立时间减少了 16%(p=0.002)。在伯格平衡量表中未观察到差异。与安慰剂组相比,多酚组的生活质量(以 LSI 为指标)提高了 39%(p=0.001):结论:补充黑加仑与习惯性活动相结合,可提高老年妇女的功能能力和生活质量,为保持独立提供了一种潜在的策略。不过,未来的研究应针对更长的持续时间来验证这些发现。
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引用次数: 0
A Novel Mutation (Lys31Arg) in the DMD Gene Impacts on Neuromuscular Dysfunctions Found by Whole Exome Sequencing and In Silico Analyses in an Iranian Family. 通过对一个伊朗家庭进行全外显子组测序和 In Silico 分析,发现 DMD 基因中的一个新突变(Lys31Arg)对神经肌肉功能障碍有影响。
Q3 Medicine Pub Date : 2024-01-01 DOI: 10.2174/0118746098280408240112112414
Vahid Omarmeli, Kai-Uwe Lewandrowski, Marjan Assefi, Hanieh Faizmahdavi, Alireza Sharafshah, Nasrin Mansouri

Background: Duchene Muscular Disorder (DMD) is a severe X-linked recessive neuromuscular disease. Previous reports predicted that one-third of cases with a fatal X-linked recessive disease will be caused by a novel mutation, and the mutation rate for DMD seems to be higher in males.

Objective: A novel mutation in the DMD gene DMD (NM_004006.3):c.92A>G (p.Lys31Arg) is suggested for males because of their heterozygous mothers carrying the mutant alleles.

Method: Whole Exome Sequencing (WES) was done for a 25-year-old female followed by the screening of the novel mutation in her parents and her brother by the Sanger sequencing technique. Some in silico analyses were run to find the putative alterations in wild-type and mutant structures by PolyPhen-2 and Mupro. Notably, SWISS-MODEL was performed to build a reliable model for the mutant allele based on the PDB ID: 1DXX structure. Also, superimposition was done by PyMol.

Results: WES analysis revealed three novel mutations including DLD (exon13:c.G1382A:p. G461E), ABCA3 (exon12:c.G1404C:p.W468C), and DMD (exon2:c.A92G:p.K31R) in the case. Focusing on DMD mutation, Sanger sequencing of the patient's parents and brother indicated no mutant allele in her mother and brother but a mutant allele in her father as a hemizygous pattern. In silico analyses showed no considerable change regarding pathogenic impact.

Conclusion: In conclusion, our findings revealed no pathogenic effect of the new mutation (K31R) of the DMD gene in an Iranian 25-year-old woman. Because of the DMD importance in preclinical diagnosis, these data may shed a light on the diagnosis of this mutation in future pregnancies.

背景介绍杜氏肌肉病(DMD)是一种严重的X连锁隐性神经肌肉病。以前的报告预测,在致命的 X 连锁隐性疾病中,有三分之一的病例是由新型突变引起的,而 DMD 的突变率似乎在男性中更高:目的:DMD基因DMD(NM_004006.3)中的一个新突变:c.92A>G(p.Lys31Arg)被认为是男性的突变,因为他们的母亲是携带突变等位基因的杂合子:方法:对一名 25 岁的女性进行了全外显子组测序(WES),然后用 Sanger 测序技术在其父母和兄弟中筛查了新型突变。通过 PolyPhen-2 和 Mupro,对野生型和突变型结构中的推测改变进行了一些默观分析。值得注意的是,通过 SWISS-MODEL,我们根据 PDB ID:1DXX 结构为突变等位基因建立了一个可靠的模型。此外,还利用 PyMol 进行了叠加:结果:WES分析发现了病例中的三个新突变,包括DLD(exon13:c.G1382A:p.G461E)、ABCA3(exon12:c.G1404C:p.W468C)和DMD(exon2:c.A92G:p.K31R)。针对 DMD 基因突变,对患者的父母和兄弟进行了 Sanger 测序,结果显示其母亲和兄弟中没有突变等位基因,但其父亲中存在突变等位基因,为半等位基因模式。硅学分析表明,该基因对致病性的影响没有显著变化:总之,我们的研究结果表明,在一名 25 岁的伊朗女性身上,DMD 基因的新突变 (K31R) 没有致病作用。鉴于 DMD 在临床前诊断中的重要性,这些数据可能会对今后妊娠中该基因突变的诊断有所启示。
{"title":"A Novel Mutation (Lys31Arg) in the DMD Gene Impacts on Neuromuscular Dysfunctions Found by Whole Exome Sequencing and <i>In Silico</i> Analyses in an Iranian Family.","authors":"Vahid Omarmeli, Kai-Uwe Lewandrowski, Marjan Assefi, Hanieh Faizmahdavi, Alireza Sharafshah, Nasrin Mansouri","doi":"10.2174/0118746098280408240112112414","DOIUrl":"10.2174/0118746098280408240112112414","url":null,"abstract":"<p><strong>Background: </strong>Duchene Muscular Disorder (DMD) is a severe X-linked recessive neuromuscular disease. Previous reports predicted that one-third of cases with a fatal X-linked recessive disease will be caused by a novel mutation, and the mutation rate for DMD seems to be higher in males.</p><p><strong>Objective: </strong>A novel mutation in the DMD gene DMD (NM_004006.3):c.92A>G (p.Lys31Arg) is suggested for males because of their heterozygous mothers carrying the mutant alleles.</p><p><strong>Method: </strong>Whole Exome Sequencing (WES) was done for a 25-year-old female followed by the screening of the novel mutation in her parents and her brother by the Sanger sequencing technique. Some in silico analyses were run to find the putative alterations in wild-type and mutant structures by PolyPhen-2 and Mupro. Notably, SWISS-MODEL was performed to build a reliable model for the mutant allele based on the PDB ID: 1DXX structure. Also, superimposition was done by PyMol.</p><p><strong>Results: </strong>WES analysis revealed three novel mutations including DLD (exon13:c.G1382A:p. G461E), ABCA3 (exon12:c.G1404C:p.W468C), and DMD (exon2:c.A92G:p.K31R) in the case. Focusing on DMD mutation, Sanger sequencing of the patient's parents and brother indicated no mutant allele in her mother and brother but a mutant allele in her father as a hemizygous pattern. In silico analyses showed no considerable change regarding pathogenic impact.</p><p><strong>Conclusion: </strong>In conclusion, our findings revealed no pathogenic effect of the new mutation (K31R) of the DMD gene in an Iranian 25-year-old woman. Because of the DMD importance in preclinical diagnosis, these data may shed a light on the diagnosis of this mutation in future pregnancies.</p>","PeriodicalId":11008,"journal":{"name":"Current aging science","volume":" ","pages":"169-174"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139542156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and Related Factors of Dizziness Among Older Adults: A Cross-Sectional Study in Ardakan City, Iran. 伊朗阿尔达坎市老年人头晕患病率及相关因素的横断面研究:伊朗阿尔达坎市横断面研究》。
Q3 Medicine Pub Date : 2024-01-01 DOI: 10.2174/0118746098277513240207070946
Mohammad Ail Morowatisharifabad, Mahdieh Hosseini Sharifabad, Marzieh Aboutorabi-Zarchi

Background: Dizziness and balance disorders are directly related to aging in humans- Dizziness is one of the most important factors causing the burden of disability after the age of 65. Bearing in mind the increase in the elderly population in Iran and the world and the prevalence of dizziness in old age, early diagnosis of dizziness and determination of the factors affecting its severity facilitate its treatment and are effective in preventing its adverse consequences.

Objective: To determine the prevalence of dizziness and its related factors among older adults in Ardakan city, Yazd province, Iran, in 2022.

Methods: This cross-sectional study was conducted in four comprehensive health centers of Ardakan city with the participation of 260 elderly people aged ≥60 years, who were randomly included in the study. Data were collected using a series of questionnaires which were completed by interviewing the participants. The variables of this study included demographic information, information related to the dizziness status, diseases, medications, use of mobility aids, physical activity level, fear of falling, quality of life and depression.

Results: The prevalence of dizziness among older adults of Ardakan city was 48.5%. In terms of the severity of dizziness, 38.8% had substantial dizziness, and 9.6% had mild dizziness. Dizziness was significantly related to physical activity (p<0.05), fear of falling (p <0.01), depression (p <0.05), history of falling (p <0.01), use of mobility aids (p <0.01), age (p<0.01), education level (p<0.01), gender (p <0.05) and diseases such as high blood pressure (p<0.05), hypothyroidism (p <0.01) and ear diseases(p <0.01). Also, elderly people with dizziness used significantly more medications such as sedatives (p<0.01), antihypertensive drugs (p <0.05) and cytotoxic drugs (p <0.01).

Conclusion: About half of the older adults experience dizziness, and this problem is associated with depression, fear of falling, history of falling, low physical activity, age, female gender, ear diseases, high blood pressure, and hypothyroidism. In addition, the use of medications such as anti- hypertensives, sedatives and cytotoxic drugs is related to dizziness. Families with elderly people, doctors and healthcare workers need to be educated and pay more attention to the above.

背景:头晕和平衡失调与人类的衰老直接相关--头晕是造成 65 岁以后残疾负担的最重要因素之一。考虑到伊朗和世界老年人口的增加以及老年人头晕的普遍性,对头晕进行早期诊断并确定影响其严重程度的因素有助于治疗,并能有效预防其不良后果:确定 2022 年伊朗亚兹德省阿尔达坎市老年人头晕的患病率及其相关因素:这项横断面研究在阿尔达坎市的四家综合医疗中心进行,随机纳入了 260 名年龄≥60 岁的老年人。数据收集采用了一系列调查问卷,通过与参与者面谈的方式完成。研究变量包括人口统计学信息、与头晕状况相关的信息、疾病、药物、助行器的使用、体力活动水平、跌倒恐惧、生活质量和抑郁:阿尔达坎市老年人的头晕患病率为 48.5%。就头晕的严重程度而言,38.8%的人有严重头晕,9.6%的人有轻度头晕。头晕与体力活动有明显关系(p 结论:约有一半的老年人有头晕的症状,这一问题与抑郁、害怕跌倒、有跌倒史、体力活动少、年龄、女性性别、耳部疾病、高血压和甲状腺功能减退症有关。此外,抗高血压药、镇静剂和细胞毒性药物等药物的使用也与头晕有关。有老年人的家庭、医生和医护人员需要对老年人进行教育,并对上述情况给予更多关注。
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Current aging science
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