Pub Date : 2022-11-25DOI: 10.2174/1573404819666221125095418
Samira Dehghani, T. J. Bozorgan, A. Mahmoodi, Reza Hosseiniara
Urine alkalinization with oral sodium bicarbonate seems to improve urinary symptoms in female patients with overactive bladder with acidic urinary pH. Therefore, the aim of this study was to compare the effect of oral sodium bicarbonate and tolterodine in women with symptoms of overactive bladder with acidic urinary pH. In this single-blind randomized clinical trial, 72 female patients with symptoms of overactive bladder syndrome with acidic urinary pH in the age group of 28-60 years were referred to the gynecology clinic of Mahdieh Hospital affiliated with Shahid Beheshti University of Medical Sciences, Tehran, Iran in 2021-2022 were studied. These patients were randomly divided into two groups oral sodium bicarbonate (36 patients) and tolterodine group (36 patients) and received the treatment for one month. Group matching was performed between patients. At the end of the study, the Overactive Bladder–Validated 8-question Awareness tool (OAB-V8), frequency, nocturia, urgency, and urinary incontinence (UI) was measured and compared between patients in the two groups. Patients were matched for age, underlying disease, BMI, acidic urinary pH, and menopause status at the baseline. After 30 days of medication therapy, a significant decrease in OAB-V8 score, frequency, nocturia, urgency, and urinary incontinence (UI) was observed in both groups receiving oral sodium bicarbonate and tolterodine in female patients with symptoms of overactive bladder syndrome with acidic urine. The degree of improvement in outcomes after treatment was similar between both groups. Oral sodium bicarbonate administration in patients with overactive bladder with acidic urinary pH has a significant positive effect on OAB-V8 symptoms, frequency, nocturia, urgency, and urinary incontinence (UI) and these results are similar to tolterodine treatment. Given that the acidic urinary pH may play a role in the etiology of an overactive bladder, it seems that sodium bicarbonate improves the symptoms of an overactive bladder by alkalizing the urine.
{"title":"Comparison of The Effect of Oral Sodium Bicarbonate And Tolterodine In Women with Symptoms of Overactive Bladder with Acidic Urine- A Single-Blind Randomized Clinical Trial","authors":"Samira Dehghani, T. J. Bozorgan, A. Mahmoodi, Reza Hosseiniara","doi":"10.2174/1573404819666221125095418","DOIUrl":"https://doi.org/10.2174/1573404819666221125095418","url":null,"abstract":"\u0000\u0000Urine alkalinization with oral sodium bicarbonate seems to improve urinary symptoms in female patients with overactive bladder with acidic urinary pH.\u0000\u0000\u0000\u0000Therefore, the aim of this study was to compare the effect of oral sodium bicarbonate and tolterodine in women with symptoms of overactive bladder with acidic urinary pH.\u0000\u0000\u0000\u0000In this single-blind randomized clinical trial, 72 female patients with symptoms of overactive bladder syndrome with acidic urinary pH in the age group of 28-60 years were referred to the gynecology clinic of Mahdieh Hospital affiliated with Shahid Beheshti University of Medical Sciences, Tehran, Iran in 2021-2022 were studied. These patients were randomly divided into two groups oral sodium bicarbonate (36 patients) and tolterodine group (36 patients) and received the treatment for one month. Group matching was performed between patients. At the end of the study, the Overactive Bladder–Validated 8-question Awareness tool (OAB-V8), frequency, nocturia, urgency, and urinary incontinence (UI) was measured and compared between patients in the two groups.\u0000\u0000\u0000\u0000Patients were matched for age, underlying disease, BMI, acidic urinary pH, and menopause status at the baseline. After 30 days of medication therapy, a significant decrease in OAB-V8 score, frequency, nocturia, urgency, and urinary incontinence (UI) was observed in both groups receiving oral sodium bicarbonate and tolterodine in female patients with symptoms of overactive bladder syndrome with acidic urine. The degree of improvement in outcomes after treatment was similar between both groups.\u0000\u0000\u0000\u0000Oral sodium bicarbonate administration in patients with overactive bladder with acidic urinary pH has a significant positive effect on OAB-V8 symptoms, frequency, nocturia, urgency, and urinary incontinence (UI) and these results are similar to tolterodine treatment. Given that the acidic urinary pH may play a role in the etiology of an overactive bladder, it seems that sodium bicarbonate improves the symptoms of an overactive bladder by alkalizing the urine.\u0000","PeriodicalId":11030,"journal":{"name":"Current Women s Health Reviews","volume":"81 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80974910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Performing myomectomy concurrently with a caesarean section has been controversial for many decades. The present study mainly aims to evaluate the consequences of concurrent myomectomy and caesarean section versus caesarean section alone. In this systematic review, we have followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Electronic resources, such as MEDLINE, Cochrane, EMBASE, Scopus, and PubMed, were searched. A total of 3057 articles were reviewed. Of these, 33 met the inclusion criteria and were included in the final analysis. The reviewed outcomes were hemoglobin (Hb) before and after the operation, blood transfusion rate, hemorrhage, operation time, duration of hospitalization, and complications, such as fever. A meta-analysis of 33 articles with 5586 participants in the caesarean myomectomy (CM) group and 2935 participants in the caesarean section (CS) group showed a statistically significant Hb decrease in the CM group [MD = 0.26, CI=95%(-0.33 to -0.19)]. The transfusion rate was higher in the CM group [OR=0.39(0.42-0.67)], and intraoperative hemorrhage was higher in the CM group [OR=0.56 (0.45 - 0.75) CI=95%]. The mean operation time [MD=1.17(1.10 -1.24) CI=95] and hospitalization time [MD=0.41 (0.34-0.48) CI=95%] were significantly higher in the CM group. There was no significant difference in the incidence of fever between the two groups [MD =1.06, CI=95%, p=0.923(0.78-1.43)]. Concurrent CM is associated with a reduction in mean Hb and an increase in operation time and hospitalization time; however, it prevents additional surgery and costs; it is worthwhile to perform myomectomy at the time of caesarean section, especially by experienced surgeons with necessary preparations.
{"title":"Consequences of Concurrent Myomectomy and Caesarean Section versus Caesarean Section Alone in the Last Two Decades: Systematic Review and Meta-analysis","authors":"Maryam Vaezi, Maryam Mohammadi Youshanloie, Fariba Pashazadeh","doi":"10.2174/1573404819666221115113516","DOIUrl":"https://doi.org/10.2174/1573404819666221115113516","url":null,"abstract":"\u0000\u0000Performing myomectomy concurrently with a caesarean section has been controversial for many decades.\u0000\u0000\u0000\u0000The present study mainly aims to evaluate the consequences of concurrent myomectomy and caesarean section versus caesarean section alone.\u0000\u0000\u0000\u0000In this systematic review, we have followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Electronic resources, such as MEDLINE, Cochrane, EMBASE, Scopus, and PubMed, were searched. A total of 3057 articles were reviewed. Of these, 33 met the inclusion criteria and were included in the final analysis. The reviewed outcomes were hemoglobin (Hb) before and after the operation, blood transfusion rate, hemorrhage, operation time, duration of hospitalization, and complications, such as fever.\u0000\u0000\u0000\u0000A meta-analysis of 33 articles with 5586 participants in the caesarean myomectomy (CM) group and 2935 participants in the caesarean section (CS) group showed a statistically significant Hb decrease in the CM group [MD = 0.26, CI=95%(-0.33 to -0.19)]. The transfusion rate was higher in the CM group [OR=0.39(0.42-0.67)], and intraoperative hemorrhage was higher in the CM group [OR=0.56 (0.45 - 0.75) CI=95%]. The mean operation time [MD=1.17(1.10 -1.24) CI=95] and hospitalization time [MD=0.41 (0.34-0.48) CI=95%] were significantly higher in the CM group. There was no significant difference in the incidence of fever between the two groups [MD =1.06, CI=95%, p=0.923(0.78-1.43)].\u0000\u0000\u0000\u0000Concurrent CM is associated with a reduction in mean Hb and an increase in operation time and hospitalization time; however, it prevents additional surgery and costs; it is worthwhile to perform myomectomy at the time of caesarean section, especially by experienced surgeons with necessary preparations.\u0000","PeriodicalId":11030,"journal":{"name":"Current Women s Health Reviews","volume":"8 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84531825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}