Pub Date : 2023-07-13DOI: 10.2174/1573404820666230713104512
N. Sanli̇er, Kadriye Erdogan, N. Sanlier
This review discusses epigenetic mechanisms and the relationship of infertility in men and women in relation to parameters pertaining to nutrition. A review of the line of the literature was conducted prior to June 2021 through the selected websites, including MEDLINE, Embase, Web of Science, www.ClinicalTrials.gov, Cochrane Central, PubMed, Google Scholar, Science Direct, and the WHO. The prevalence of infertility worldwide is 8-12%, and one out of every 8 couples receives medical treatment. Epigenetic mechanisms, aging, environmental factors, dietary energy and nutrients and non-nutrient compounds; more or less energy intake, and methionine play a role in the onset of infertility. Furthermore, more factors that contribute to infertility include the vitamins B12, D, and B6, biotin, choline, selenium, zinc, folic acid, resveratrol, quercetin, and others.. To understand the molecular mechanisms regulating the expression of genes that affect infertility, the environment, the role of genotype, age, health, nutrition, and changes in the individual's epigenotype must first be considered. This will pave the way for the identification of the unknown causes of infertility. Insufficient or excessive intake of energy and certain macro and micronutrients may contribute to the occurrence of infertility as well. In addition, it is reported that 5-10% of body weight loss, moderate physical activity and nutritional interventions for improvement in insulin sensitivity contribute to the development of fertility. Epigenetic processes involve inherited changes but not encoded by the DNA sequence itself. Nutrition is thought to affect the epigenetic mechanisms that play a role in the pathogenesis of many diseases, including infertility. Epigenetic mechanisms of individuals with infertility are different from healthy individuals. Infertility is associated with epigenetic mechanisms, nutrients, bioactive components and numerous other factors.
本文综述了表观遗传机制以及与营养参数有关的男性和女性不育症的关系。在2021年6月之前，通过选定的网站对文献进行了综述，包括MEDLINE、Embase、Web of Science、www.ClinicalTrials.gov、Cochrane Central、PubMed、Google Scholar、Science Direct和WHO。全世界的不孕症发病率为8-12%，每8对夫妇中就有一对接受治疗。表观遗传机制、衰老、环境因素、膳食能量和营养素及非营养素化合物;能量摄入多或少，与蛋氨酸在不孕症发病中起作用。此外，导致不孕的因素还包括维生素B12、D和B6、生物素、胆碱、硒、锌、叶酸、白藜芦醇、槲皮素等。要了解影响不孕的基因表达的分子机制，必须首先考虑环境、基因型、年龄、健康、营养和个体表观基因型变化的作用。这将为确定不孕不育的未知原因铺平道路。能量和某些宏量和微量营养素摄入不足或过量也可能导致不孕症的发生。此外，据报道，体重减轻5-10%、适度体育活动和改善胰岛素敏感性的营养干预有助于生育能力的发展。表观遗传过程包括遗传变化，但不是由DNA序列本身编码的。营养被认为影响表观遗传机制，在许多疾病的发病机制中发挥作用，包括不孕症。不孕症个体的表观遗传机制与健康个体不同。不孕症与表观遗传机制、营养物质、生物活性成分和许多其他因素有关。
{"title":"Relevance of infertility, epigenetics, nutrient, and bioactive components: A review of the literature","authors":"N. Sanli̇er, Kadriye Erdogan, N. Sanlier","doi":"10.2174/1573404820666230713104512","DOIUrl":"https://doi.org/10.2174/1573404820666230713104512","url":null,"abstract":"\u0000\u0000This review discusses epigenetic mechanisms and the relationship of infertility in men and women in relation to parameters pertaining to nutrition.\u0000\u0000\u0000\u0000A review of the line of the literature was conducted prior to June 2021 through the selected websites, including MEDLINE, Embase, Web of Science, www.ClinicalTrials.gov, Cochrane Central, PubMed, Google Scholar, Science Direct, and the WHO.\u0000\u0000\u0000\u0000The prevalence of infertility worldwide is 8-12%, and one out of every 8 couples receives medical treatment. Epigenetic mechanisms, aging, environmental factors, dietary energy and nutrients and non-nutrient compounds; more or less energy intake, and methionine play a role in the onset of infertility. Furthermore, more factors that contribute to infertility include the vitamins B12, D, and B6, biotin, choline, selenium, zinc, folic acid, resveratrol, quercetin, and others..\u0000\u0000\u0000\u0000To understand the molecular mechanisms regulating the expression of genes that affect infertility, the environment, the role of genotype, age, health, nutrition, and changes in the individual's epigenotype must first be considered. This will pave the way for the identification of the unknown causes of infertility. Insufficient or excessive intake of energy and certain macro and micronutrients may contribute to the occurrence of infertility as well. In addition, it is reported that 5-10% of body weight loss, moderate physical activity and nutritional interventions for improvement in insulin sensitivity contribute to the development of fertility.\u0000\u0000\u0000\u0000Epigenetic processes involve inherited changes but not encoded by the DNA sequence itself. Nutrition is thought to affect the epigenetic mechanisms that play a role in the pathogenesis of many diseases, including infertility. Epigenetic mechanisms of individuals with infertility are different from healthy individuals. Infertility is associated with epigenetic mechanisms, nutrients, bioactive components and numerous other factors.\u0000","PeriodicalId":11030,"journal":{"name":"Current Women s Health Reviews","volume":"3 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86127301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-13DOI: 10.2174/1573404820666230713110902
Pervej Alom Barbhuiya, Shahil Arman, Hrishika Paul, Saikat Sen, B. Dey, Manash Pratim Pathak
Breast cancer is one of the most common types of cancer in women globally, which poses a significant public health threat on a global scale. Continuous updates of the recent development in terms of drug development and diagnosis are the key to decoding the complexity of the location-specific different forms of breast cancer. The aim of this review is to sifter out the current advances and status of drugs, treatments, therapies and technologies related to breast cancer. The authors searched for a number of article sources, and all possible data was collected from different databases like MEDLINE, EMBASE, Pub Med, Web of Science and Google Scholar. to identify recent development in drug development and diagnosis. After a detailed literature survey, it was found that in drug discovery, a number of new drug candidates for breast cancer have completed clinical trials; in the diagnosis of breast cancer, a number of new technologies like artificial intelligence (AI), smart bra, smart vest, clinical breast exam have developed. It was found that breast self-awareness has immense importance in the early detection of breast cancer, which is par with the accuracy of modern diagnostic tools. An effort has been made to present all the updated data related to recent drug development, like surveillance status of drugs in clinical trials, diagnosis and social stigma of people with breast cancer recovery. Recent technological advances have led to the development of many devices for the early detection of breast cancer, providing efficacy in line with the diagnostic tools that pave the way for early treatment using effective drug candidates.
乳腺癌是全球妇女中最常见的癌症类型之一，在全球范围内对公共卫生构成重大威胁。在药物开发和诊断方面不断更新的最新发展是解码位置特异性不同形式乳腺癌复杂性的关键。本文旨在梳理乳腺癌相关药物、治疗、疗法和技术的最新进展和现状。作者搜索了大量的文章来源，所有可能的数据都是从MEDLINE、EMBASE、Pub Med、Web of Science和Google Scholar等不同的数据库中收集的。确定药物开发和诊断的最新进展。经过详细的文献调查，发现在药物发现方面，已有一批乳腺癌新药候选药物完成了临床试验;在乳腺癌诊断方面，人工智能(AI)、智能胸罩、智能背心、临床乳腺检查等一批新技术得到发展。研究发现，乳房自我意识在乳腺癌的早期发现中具有巨大的重要性，这与现代诊断工具的准确性相当。我们努力展示与最近药物开发有关的所有最新数据，如临床试验中药物的监测状况、乳腺癌康复患者的诊断和社会耻辱。最近的技术进步导致了许多用于早期检测乳腺癌的设备的发展，提供符合诊断工具的功效，为使用有效的候选药物进行早期治疗铺平了道路。
{"title":"An updated review on the early detection and drug development targeting breast cancer","authors":"Pervej Alom Barbhuiya, Shahil Arman, Hrishika Paul, Saikat Sen, B. Dey, Manash Pratim Pathak","doi":"10.2174/1573404820666230713110902","DOIUrl":"https://doi.org/10.2174/1573404820666230713110902","url":null,"abstract":"\u0000\u0000Breast cancer is one of the most common types of cancer in women globally, which poses a significant public health threat on a global scale. Continuous updates of the recent development in terms of drug development and diagnosis are the key to decoding the complexity of the location-specific different forms of breast cancer. The aim of this review is to sifter out the current advances and status of drugs, treatments, therapies and technologies related to breast cancer.\u0000\u0000\u0000\u0000The authors searched for a number of article sources, and all possible data was collected from different databases like MEDLINE, EMBASE, Pub Med, Web of Science and Google Scholar. to identify recent development in drug development and diagnosis.\u0000\u0000\u0000\u0000After a detailed literature survey, it was found that in drug discovery, a number of new drug candidates for breast cancer have completed clinical trials; in the diagnosis of breast cancer, a number of new technologies like artificial intelligence (AI), smart bra, smart vest, clinical breast exam have developed. It was found that breast self-awareness has immense importance in the early detection of breast cancer, which is par with the accuracy of modern diagnostic tools.\u0000\u0000\u0000\u0000An effort has been made to present all the updated data related to recent drug development, like surveillance status of drugs in clinical trials, diagnosis and social stigma of people with breast cancer recovery. Recent technological advances have led to the development of many devices for the early detection of breast cancer, providing efficacy in line with the diagnostic tools that pave the way for early treatment using effective drug candidates.\u0000","PeriodicalId":11030,"journal":{"name":"Current Women s Health Reviews","volume":"130 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86770270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-12DOI: 10.2174/1573404820666230712125718
A. Wal, P. Wal, B. Dash, Divyanshi Gupta, Srishti Morris, Prachi, Vibhu Sahani, A. Rai
Although pregnancy has been an integral part of women’s lives for millennia, not all women have found the process comfortable. About 65 percent of women in India consume Indian traditional herbs during pregnancy. Herbal medicines are used nowadays by up to half of the world's population. Phytomedicines isolated from plants contain a wide variety of bioactive components that can have both negative and positive effects. Many herbal plants, such as Sage (Salvia fruticosa), golden cotula (Matricaria aurea), anise (P. anisum), peppermint (Mentha aquatica), and cumin (Cuminum cyminum), etc., are used in pregnancy. To minimize the adverse effects, the use of Indian traditional medicine can be the best possible alternative. Regarding the usage of herbal medicines in India, there are large research gaps and a lack of a regulatory framework. This article aims to highlight the most common traditional Indian remedies used by pregnant women, along with their uses and any possible interactions between herbal remedies and prescription drugs. Several databases, including the WHO guidelines, PubMed, Bentham Science, Elsevier, Springer Nature, Wiley, and Research Gate, were used to compile the data for the article following a thorough analysis of the various research findings connected to pregnancy and herbs for pregnancy care. An overview of the use of herbal medicine is given in this review, along with information on its limitations and general safety. The prevalence of herbal medicine use during pregnancy in India is then discussed, along with the uses, adverse effects, side effects, and efficacy of the most popular herbal medications. The use of herbal medicine during pregnancy is a common phenomenon. The outcomes of this study showed Indian Traditional medicines are known to have numerous advantages that can be helpful during or after pregnancy, including raising milk production, reducing nausea, easing labor pains, reducing morning sickness, or reducing flatulence, however, some herbal remedies have the potential to be teratogenic, poisonous, and abortive, especially during the first trimester of pregnancy because the active components of some medicinal plants can cross the placental barrier and get to the foetus. To determine the safety of taking herbal medications, studies, especially clinical trial trials, must be conducted.
{"title":"A Mini Review of the Literature with a Special Focus on India on the Prevalence of Indian Traditional Medicine (ITM) Use During Pregnancy","authors":"A. Wal, P. Wal, B. Dash, Divyanshi Gupta, Srishti Morris, Prachi, Vibhu Sahani, A. Rai","doi":"10.2174/1573404820666230712125718","DOIUrl":"https://doi.org/10.2174/1573404820666230712125718","url":null,"abstract":"\u0000\u0000Although pregnancy has been an integral part of women’s lives for millennia, not all women have found the process comfortable. About 65 percent of women in India consume Indian traditional herbs during pregnancy. Herbal medicines are used nowadays by up to half of the world's population. Phytomedicines isolated from plants contain a wide variety of bioactive components that can have both negative and positive effects. Many herbal plants, such as Sage (Salvia fruticosa), golden cotula (Matricaria aurea), anise (P. anisum), peppermint (Mentha aquatica), and cumin (Cuminum cyminum), etc., are used in pregnancy. To minimize the adverse effects, the use of Indian traditional medicine can be the best possible alternative.\u0000\u0000\u0000\u0000Regarding the usage of herbal medicines in India, there are large research gaps and a lack of a regulatory framework. This article aims to highlight the most common traditional Indian remedies used by pregnant women, along with their uses and any possible interactions between herbal remedies and prescription drugs.\u0000\u0000\u0000\u0000Several databases, including the WHO guidelines, PubMed, Bentham Science, Elsevier, Springer Nature, Wiley, and Research Gate, were used to compile the data for the article following a thorough analysis of the various research findings connected to pregnancy and herbs for pregnancy care.\u0000\u0000\u0000\u0000An overview of the use of herbal medicine is given in this review, along with information on its limitations and general safety. The prevalence of herbal medicine use during pregnancy in India is then discussed, along with the uses, adverse effects, side effects, and efficacy of the most popular herbal medications.\u0000\u0000\u0000\u0000The use of herbal medicine during pregnancy is a common phenomenon. The outcomes of this study showed Indian Traditional medicines are known to have numerous advantages that can be helpful during or after pregnancy, including raising milk production, reducing nausea, easing labor pains, reducing morning sickness, or reducing flatulence, however, some herbal remedies have the potential to be teratogenic, poisonous, and abortive, especially during the first trimester of pregnancy because the active components of some medicinal plants can cross the placental barrier and get to the foetus. To determine the safety of taking herbal medications, studies, especially clinical trial trials, must be conducted.\u0000","PeriodicalId":11030,"journal":{"name":"Current Women s Health Reviews","volume":"16 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91384626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-06DOI: 10.2174/1573404820666230706105736
K. Mekki, Azzeddine Senouci, Wassila Benhabib, Rahmouna Fizi
The purpose of the study was to assess the effects of a lifestyle promotion based on the principles of the Mediterranean diet (MD) combined with regular physical exercise on climacteric symptoms, sleep quality, and quality of life in women in the menopausal transition. Among 100 perimenopausal women recruited, 80 (48 ± 2 years) with climacteric symptoms were eligible for the study and were randomized into two groups: an intervention group (n=40) that received nutritional counselling based on the principles of MD with the practice of regular activity during 8 weeks, and a control group (n=40). At baseline and 8 weeks after the initiation of nutritional intervention, we assessed daily energy expenditure and food intake, anthropometric characteristics, climacteric symptoms, sleep quality, and quality of life. Results showed that in the intervention group, compared to the control group, after 8 weeks of nutritional counselling, a significant decrease was noted in somatic and psychologic (p<0.01) symptoms. No significant difference was noted in urogenital symptoms. The quality of life was improved by the decrease of the Menopause Rating Score (-25%, p<0.001). A decrease was observed in subjective sleep quality (-27%, p<0.05), sleep duration (-39%, p<0.05), habitual sleep efficiency (-43%, p<0.05), and daytime dysfunction (-43%, p<0.01). The score of PSQI was decreased by (-31%, p<0.01), which meant that the quality of sleep improved. Anthropometric characteristics, climacteric symptoms, sleep quality and quality of life were improved in women on menopausal transition adopting a healthy lifestyle based on the principles of Mediterranean eating pattern combined with regular physical activity.
{"title":"Impact of Promoting a Healthy Lifestyle on Anthropometric Characteristics, Climacteric Symptoms, Sleep Quality, and Quality of Life in Women During Menopausal Transition","authors":"K. Mekki, Azzeddine Senouci, Wassila Benhabib, Rahmouna Fizi","doi":"10.2174/1573404820666230706105736","DOIUrl":"https://doi.org/10.2174/1573404820666230706105736","url":null,"abstract":"\u0000\u0000The purpose of the study was to assess the effects of a lifestyle promotion based on the principles of the Mediterranean diet (MD) combined with regular physical exercise on climacteric symptoms, sleep quality, and quality of life in women in the menopausal transition.\u0000\u0000\u0000\u0000Among 100 perimenopausal women recruited, 80 (48 ± 2 years) with climacteric symptoms were eligible for the study and were randomized into two groups: an intervention group (n=40) that received nutritional counselling based on the principles of MD with the practice of regular activity during 8 weeks, and a control group (n=40). At baseline and 8 weeks after the initiation of nutritional intervention, we assessed daily energy expenditure and food intake, anthropometric characteristics, climacteric symptoms, sleep quality, and quality of life.\u0000\u0000\u0000\u0000Results showed that in the intervention group, compared to the control group, after 8 weeks of nutritional counselling, a significant decrease was noted in somatic and psychologic (p<0.01) symptoms. No significant difference was noted in urogenital symptoms. The quality of life was improved by the decrease of the Menopause Rating Score (-25%, p<0.001). A decrease was observed in subjective sleep quality (-27%, p<0.05), sleep duration (-39%, p<0.05), habitual sleep efficiency (-43%, p<0.05), and daytime dysfunction (-43%, p<0.01). The score of PSQI was decreased by (-31%, p<0.01), which meant that the quality of sleep improved.\u0000\u0000\u0000\u0000Anthropometric characteristics, climacteric symptoms, sleep quality and quality of life were improved in women on menopausal transition adopting a healthy lifestyle based on the principles of Mediterranean eating pattern combined with regular physical activity.\u0000","PeriodicalId":11030,"journal":{"name":"Current Women s Health Reviews","volume":"85 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76185061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-05DOI: 10.2174/1573404820666230705162433
Fathimath Hashreen K A, Shraddha Shetty K
Fetuses with Fetal Growth Restriction (FGR) are at increased risk of chronic intra-uterine hypoxia, due to increased secretion of corticosterone from the fetal adrenal glands. This plays a major role in the cardiovascular and circulatory adaptation of FGR fetuses. These modifications are untimely identified by sonographic imaging. To study the association between ultrasound features of the adrenal gland and growth restriction in the fetus. A total of 104 pregnant women (52 FGR pregnancies and 52 controls) were evaluated between 28 and 36 weeks of gestation. All the study participants underwent transabdominal ultrasonography to measure bilateral fetal adrenal gland volume and fetal zone volume, corrected for gestational age. They were followed up until delivery. The two groups were compared to analyze the perinatal outcome in relation to ultrasonographic changes in the adrenal gland. The adrenal gland measurements were significantly larger in fetuses with FGR as compared to the control group. FGR group had a larger corrected adrenal gland volume(cAGV) and fetal zone and adrenal gland (FZ/AG)ratio A statistically significant correlation was found between the two groups regarding gestational age at delivery, birth weight, APGAR score, and NICU admissions. Perinatal morbidity was found to be higher among women diagnosed with FGR, i.e., 14 (53.84%). Fetal adrenal gland size measurement is important to identify FGR fetuses that are vulnerable to hypoxia. It helps the obstetrician prepare for effective in-utero management to reduce perinatal morbidity and mortality.
{"title":"Study of Ultrasonographic Changes of the Adrenal Gland in Growth Restricted Fetus","authors":"Fathimath Hashreen K A, Shraddha Shetty K","doi":"10.2174/1573404820666230705162433","DOIUrl":"https://doi.org/10.2174/1573404820666230705162433","url":null,"abstract":"\u0000\u0000Fetuses with Fetal Growth Restriction (FGR) are at increased risk of chronic intra-uterine hypoxia, due to increased secretion of corticosterone from the fetal adrenal glands. This plays a major role in the cardiovascular and circulatory adaptation of FGR fetuses. These modifications are untimely identified by sonographic imaging.\u0000\u0000\u0000\u0000To study the association between ultrasound features of the adrenal gland and growth restriction in the fetus.\u0000\u0000\u0000\u0000A total of 104 pregnant women (52 FGR pregnancies and 52 controls) were evaluated between 28 and 36 weeks of gestation. All the study participants underwent transabdominal ultrasonography to measure bilateral fetal adrenal gland volume and fetal zone volume, corrected for gestational age. They were followed up until delivery. The two groups were compared to analyze the perinatal outcome in relation to ultrasonographic changes in the adrenal gland.\u0000\u0000\u0000\u0000The adrenal gland measurements were significantly larger in fetuses with FGR as compared to the control group. FGR group had a larger corrected adrenal gland volume(cAGV) and fetal zone and adrenal gland (FZ/AG)ratio A statistically significant correlation was found between the two groups regarding gestational age at delivery, birth weight, APGAR score, and NICU admissions. Perinatal morbidity was found to be higher among women diagnosed with FGR, i.e., 14 (53.84%).\u0000\u0000\u0000\u0000Fetal adrenal gland size measurement is important to identify FGR fetuses that are vulnerable to hypoxia. It helps the obstetrician prepare for effective in-utero management to reduce perinatal morbidity and mortality.\u0000","PeriodicalId":11030,"journal":{"name":"Current Women s Health Reviews","volume":"276 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77062119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-26DOI: 10.2174/1573404820666230626110413
N. Minocha, K. Rao, Nikita Yadav, Nidhi Bansal
Polycystic Ovarian Syndrome (PCOS) is a hormonal disorder in females with excessive hormonal levels, but a reasonable cause is unknown. For PCOS, various pharmaceutical therapies have been offered, like oral contraceptive pills (which balance hormonal imbalances). PCOS is commonly used as an alternative to PCOD (Polycystic Ovary Disease). Although a part of the implicated mechanism in the occurrence of PCOS has been discovered, the specific etiology and pathophysiology are still unknown. Many types of complementary medicines are used to treat PCOD, and herbal medicines are one of them. Medical herbs have long been utilized to manage PCOS in women's gynecological and reproductive issues. This review article discusses the importance of herbal medicines and lifestyle modifications for PCOD patients. Many clinical studies proved that herbs like liquorice, cinnamon, Unkei-to, and fenugreek are helpful in PCOD management by improving hormone levels, ovulatory dysfunctions, obesity, and insulin resistance in the body. This review explores the natural plants that can be used to treat the disease naturally. The herbs can be used either alone or in combination.
{"title":"Essential Herbal Plants for the Clinical Management of Polycystic Ovary Syndrome and Patents for the same","authors":"N. Minocha, K. Rao, Nikita Yadav, Nidhi Bansal","doi":"10.2174/1573404820666230626110413","DOIUrl":"https://doi.org/10.2174/1573404820666230626110413","url":null,"abstract":"\u0000\u0000Polycystic Ovarian Syndrome (PCOS) is a hormonal disorder in females with excessive hormonal levels, but a reasonable cause is unknown. For PCOS, various pharmaceutical therapies have been offered, like oral contraceptive pills (which balance hormonal imbalances). PCOS is commonly used as an alternative to PCOD (Polycystic Ovary Disease). Although a part of the implicated mechanism in the occurrence of PCOS has been discovered, the specific etiology and pathophysiology are still unknown. Many types of complementary medicines are used to treat PCOD, and herbal medicines are one of them. Medical herbs have long been utilized to manage PCOS in women's gynecological and reproductive issues. This review article discusses the importance of herbal medicines and lifestyle modifications for PCOD patients. Many clinical studies proved that herbs like liquorice, cinnamon, Unkei-to, and fenugreek are helpful in PCOD management by improving hormone levels, ovulatory dysfunctions, obesity, and insulin resistance in the body. This review explores the natural plants that can be used to treat the disease naturally. The herbs can be used either alone or in combination.\u0000","PeriodicalId":11030,"journal":{"name":"Current Women s Health Reviews","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89976909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.2174/1573404820666230615112139
F. Sarbazi, E. Akbari, R. Nasr, Nayere Tamizi, Sahar Khoshravesh
One of the main problems of women of reproductive age is ectopic pregnancy. Lack of early diagnosis and treatment can lead to internal bleeding and death of the patient. Approximately 1.2 to 1.4% of the reported pregnancies is ectopic pregnancy and one of the rarest types of ectopic pregnancy is bilateral ectopic pregnancy, which is reported in only 0.0005% of pregnant women. A 35-year-old woman with polycystic ovary syndrome, weight 65 kg and height 153 cm, referred for pregnancy. Using examination and history taking, ultrasound and β-hCG titer measurement, one of the masses at 5 to 6 weeks and in the area of the isthmus of the right tube and the other mass two weeks later at 7 to 8 weeks, in the area Infundibulum of the left tube was diagnosed. The most common complication that the patient complained about was abdominal pain and frequent bleeding. Both times, the patient underwent laparoscopy and because of the patient's condition, salpingectomy was performed on both left and right tubes of the patient. Due to the rarity of bilateral twin ectopic pregnancy, early diagnosis with the help of history taking and clinical examination, measurement of β-hCG titer and ultrasound is necessary. Early diagnosis can lead to the reduction of women's mortality.
{"title":"A Rare Case Report: Bilateral Spontaneous Twin Tubal Ectopic Pregnancy from Iran","authors":"F. Sarbazi, E. Akbari, R. Nasr, Nayere Tamizi, Sahar Khoshravesh","doi":"10.2174/1573404820666230615112139","DOIUrl":"https://doi.org/10.2174/1573404820666230615112139","url":null,"abstract":"\u0000\u0000One of the main problems of women of reproductive age is ectopic pregnancy. Lack of early diagnosis and treatment can lead to internal bleeding and death of the patient. Approximately 1.2 to 1.4% of the reported pregnancies is ectopic pregnancy and one of the rarest types of ectopic pregnancy is bilateral ectopic pregnancy, which is reported in only 0.0005% of pregnant women.\u0000\u0000\u0000\u0000A 35-year-old woman with polycystic ovary syndrome, weight 65 kg and height 153 cm, referred for pregnancy. Using examination and history taking, ultrasound and β-hCG titer measurement, one of the masses at 5 to 6 weeks and in the area of the isthmus of the right tube and the other mass two weeks later at 7 to 8 weeks, in the area Infundibulum of the left tube was diagnosed. The most common complication that the patient complained about was abdominal pain and frequent bleeding. Both times, the patient underwent laparoscopy and because of the patient's condition, salpingectomy was performed on both left and right tubes of the patient.\u0000\u0000\u0000\u0000Due to the rarity of bilateral twin ectopic pregnancy, early diagnosis with the help of history taking and clinical examination, measurement of β-hCG titer and ultrasound is necessary. Early diagnosis can lead to the reduction of women's mortality.\u0000","PeriodicalId":11030,"journal":{"name":"Current Women s Health Reviews","volume":"3 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87945536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-07DOI: 10.2174/1573404820666230607104422
S. Rahayu, Edy Fakhrizal, Muhammad Yulis Hamidy
Pelvic organ prolapse (POP) may reduce women's quality of life and is one of the most important aspects in the occurrence of sexual dysfunction. This study aimed to assess sexual function in POP women with pelvic floor dysfunction pre and post-surgery. This study was a prospective cohort study. Using the total sampling technique at Arifin Achmad Hospital, Indonesia, the study recruited women who underwent POP surgery with active sexual function from July 2020 to December 2021. The pelvic floor disorder was evaluated through Pelvic Floor Distress Inventory (PFDI) questionnaires validated in the Indonesian language, pre, and post-surgery. The assessment of sexual function was carried out using the Indonesian linguistic validation of the Female Sexual Function Index (FSFI) questionnaires before and after surgery. There was a decrease in the average value of pelvic floor disorder scores before and six months after surgery (P< 0.05). However, the sexual function increased with a cut-off score of FSFI > 20.25 at 3 and 6 months post-surgery, respectively as much as 61.1% (11/18 subjects) and 72.2% (13/18 subjects), compared to the pre-surgery sexual function scores by 7.8% (5/18 subjects). Out of the 6 domains of sexual function, an increase was found in the sexual arousal domain (P<0.05). There is a decrease in pelvic floor disorder and an increase in sexual function, particularly an increment in sexual arousal at six months post-surgery.
{"title":"Female sexual function following pelvic organ prolapse reconstruction: A case serial study","authors":"S. Rahayu, Edy Fakhrizal, Muhammad Yulis Hamidy","doi":"10.2174/1573404820666230607104422","DOIUrl":"https://doi.org/10.2174/1573404820666230607104422","url":null,"abstract":"\u0000\u0000Pelvic organ prolapse (POP) may reduce women's quality of life and is one of the most important aspects in the occurrence of sexual dysfunction.\u0000\u0000\u0000\u0000This study aimed to assess sexual function in POP women with pelvic floor dysfunction pre and post-surgery.\u0000\u0000\u0000\u0000This study was a prospective cohort study. Using the total sampling technique at Arifin Achmad Hospital, Indonesia, the study recruited women who underwent POP surgery with active sexual function from July 2020 to December 2021. The pelvic floor disorder was evaluated through Pelvic Floor Distress Inventory (PFDI) questionnaires validated in the Indonesian language, pre, and post-surgery. The assessment of sexual function was carried out using the Indonesian linguistic validation of the Female Sexual Function Index (FSFI) questionnaires before and after surgery.\u0000\u0000\u0000\u0000There was a decrease in the average value of pelvic floor disorder scores before and six months after surgery (P< 0.05). However, the sexual function increased with a cut-off score of FSFI > 20.25 at 3 and 6 months post-surgery, respectively as much as 61.1% (11/18 subjects) and 72.2% (13/18 subjects), compared to the pre-surgery sexual function scores by 7.8% (5/18 subjects). Out of the 6 domains of sexual function, an increase was found in the sexual arousal domain (P<0.05).\u0000\u0000\u0000\u0000There is a decrease in pelvic floor disorder and an increase in sexual function, particularly an increment in sexual arousal at six months post-surgery.\u0000","PeriodicalId":11030,"journal":{"name":"Current Women s Health Reviews","volume":"25 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81892256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-06DOI: 10.2174/1573404820666230606160811
S. Masoumi, Marzieh aotogara, Masoumeh Rostami-Moez, F. farahani, S. Alimohammadi, K. Oshvandi
Menopause is one of a woman's most crucial life stages. Identifying menopause's educational needs is critical. This study aims to explain the educational needs of women during menopause. The current study employs a qualitative content analysis method. The study included 12 women around menopause who were referred to Fatemieh Hospital's menopause clinic in Hamadan in 2020 and seven midwives. Individual semi-structured interviews with open-ended questions were used to collect data for the study. Data analysis was performed by Cheevakumjon method and conceptual content analysis was used to extract the concepts. After reading the text of the data, key sentences and concepts were derived and finally categorized. The mean age of menopausal women and midwives was 54.15±4.24 and 34.35±3.54 years, respectively. In this study, three main themes were found in each of the perspectives of menopausal women (educational needs, expectations from the health system, expectations from others) and nurse-midwives (effective factors in the successful implementation of programs related to the health of menopausal women, obstacles and challenges of successful program implementation, strategies to increase program performance) regarding health needs related to menopause. The experiences of postmenopausal women had 3 themes, 4 categories and 15 subcategories and midwives' point of view was also divided into 3 themes and 5 categories and 14 sub categories. In order to manage the challenges of menopause, education and counseling are needed regarding the physical, mental, psychological and social changes that menopausal women may face. Moreover, to achieve these goals, there is a need for comprehensive support from the relevant politicians.
{"title":"Explanation Of The Educational Needs Related To Women's Health During Menopausal Period: A Qualitative Study","authors":"S. Masoumi, Marzieh aotogara, Masoumeh Rostami-Moez, F. farahani, S. Alimohammadi, K. Oshvandi","doi":"10.2174/1573404820666230606160811","DOIUrl":"https://doi.org/10.2174/1573404820666230606160811","url":null,"abstract":"\u0000\u0000Menopause is one of a woman's most crucial life stages. Identifying menopause's educational needs is critical.\u0000\u0000\u0000\u0000This study aims to explain the educational needs of women during menopause.\u0000\u0000\u0000\u0000The current study employs a qualitative content analysis method. The study included 12 women around menopause who were referred to Fatemieh Hospital's menopause clinic in Hamadan in 2020 and seven midwives. Individual semi-structured interviews with open-ended questions were used to collect data for the study. Data analysis was performed by Cheevakumjon method and conceptual content analysis was used to extract the concepts. After reading the text of the data, key sentences and concepts were derived and finally categorized.\u0000\u0000\u0000\u0000The mean age of menopausal women and midwives was 54.15±4.24 and 34.35±3.54 years, respectively. In this study, three main themes were found in each of the perspectives of menopausal women (educational needs, expectations from the health system, expectations from others) and nurse-midwives (effective factors in the successful implementation of programs related to the health of menopausal women, obstacles and challenges of successful program implementation, strategies to increase program performance) regarding health needs related to menopause. The experiences of postmenopausal women had 3 themes, 4 categories and 15 subcategories and midwives' point of view was also divided into 3 themes and 5 categories and 14 sub categories.\u0000\u0000\u0000\u0000In order to manage the challenges of menopause, education and counseling are needed regarding the physical, mental, psychological and social changes that menopausal women may face. Moreover, to achieve these goals, there is a need for comprehensive support from the relevant politicians.\u0000","PeriodicalId":11030,"journal":{"name":"Current Women s Health Reviews","volume":"5 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87562154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-19DOI: 10.2174/1573404820666230519123920
F. Kazemi, N. Soleimani, M. Refaei
During labor and delivery, mothers should be supported by people who give them comfort. The present study aims to determine the effect of continued midwifery support in labor on the childbirth experience and self-esteem of nulliparous women 6 weeks after childbirth. This randomized controlled trial was performed in 2021 on 70 pregnant women in the delivery ward. Participants were allocated to two groups through balanced block randomization. First, participants completed questionnaires. In the intervention group, the researcher stayed at the mother’s bedside and accompanied the mother continuously throughout the labor and up to 2 hours after childbirth. Both groups received routine care. Six weeks after childbirth, participants in both groups were contacted to complete the CEQ 2.0 and Rosenberg self-esteem questionnaires. The required data were collected and analyzed at a significance level of 0.05. The mean (± SD) of childbirth experience 6 weeks after childbirth was 3.1 (± 0.2) in the intervention group and 2.6 (± 0.3) in the control group, and this difference was statistically significant (p < 0.001) (Cohen’s d = 1.7; 95% CI: 1.1, 2.3). The comparison of the mean of maternal self-esteem showed that this rate in the intervention group was 2.1 scores higher than that in the control group, and the difference was statistically significant (p = 0.02) (Cohen’s d = 0.6; 95% CI: 0.1, 1.1). Continued support of the midwife in labor and up to 2 hours after childbirth can lead to a better childbirth experience and enhance the mother’s self-esteem up to 6 weeks after childbirth.
{"title":"Effect of Continued Midwifery Support in Labor on Childbirth Experience and Self-esteem of Primipara Women: A Randomized Controlled Trial","authors":"F. Kazemi, N. Soleimani, M. Refaei","doi":"10.2174/1573404820666230519123920","DOIUrl":"https://doi.org/10.2174/1573404820666230519123920","url":null,"abstract":"\u0000\u0000During labor and delivery, mothers should be supported by people who give them comfort. The present study aims to determine the effect of continued midwifery support in labor on the childbirth experience and self-esteem of nulliparous women 6 weeks after childbirth.\u0000\u0000\u0000\u0000This randomized controlled trial was performed in 2021 on 70 pregnant women in the delivery ward. Participants were allocated to two groups through balanced block randomization. First, participants completed questionnaires. In the intervention group, the researcher stayed at the mother’s bedside and accompanied the mother continuously throughout the labor and up to 2 hours after childbirth. Both groups received routine care. Six weeks after childbirth, participants in both groups were contacted to complete the CEQ 2.0 and Rosenberg self-esteem questionnaires. The required data were collected and analyzed at a significance level of 0.05.\u0000\u0000\u0000\u0000The mean (± SD) of childbirth experience 6 weeks after childbirth was 3.1 (± 0.2) in the intervention group and 2.6 (± 0.3) in the control group, and this difference was statistically significant (p < 0.001) (Cohen’s d = 1.7; 95% CI: 1.1, 2.3). The comparison of the mean of maternal self-esteem showed that this rate in the intervention group was 2.1 scores higher than that in the control group, and the difference was statistically significant (p = 0.02) (Cohen’s d = 0.6; 95% CI: 0.1, 1.1).\u0000\u0000\u0000\u0000Continued support of the midwife in labor and up to 2 hours after childbirth can lead to a better childbirth experience and enhance the mother’s self-esteem up to 6 weeks after childbirth.\u0000","PeriodicalId":11030,"journal":{"name":"Current Women s Health Reviews","volume":"61 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85890359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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