Pub Date : 2023-05-18DOI: 10.2174/1573404820666230518103039
O. Vasilj, Mateja Vujica Ferenc, A. Šerman, V. Blagaić, Milan Milošević, M. Pavlović, Ivanka Bekavac Vlatković
Pelvic inflammatory disease (PID) is a public health problem that demands rapid diagnosis and treatment and may severely impair female reproductive health. To analyze anamnestic information, laboratory findings, and clinical and microbiological features of patients with severe acute PID that underwent a surgical procedure. This retrospective study enrolled 97 cases that were surgically treated in the Department of Obstetrics and Gynecology, Clinical Hospital „Sveti Duh“ between 2009 and 2019. Most women were within the age group 35-44 (38.14%). Lower abdominal pain was the most common symptom (92.78%). Compared to intraoperatively confirmed PID, C-reactive protein (CRP) yielded the highest sensitivity (88.10%) while cervical motion tenderness possessed the highest specificity (53.85%). The tubo-ovarian abscess was detected in 35.05% of intraoperative specimens, mainly occurring in women between 45-54 years (P=0.017) and absent between 15-24 (P=0.012) and 25-34 years (P=0.049). The length of hospital stay was influenced by the number of symptoms (ρ=0.316, P=0.002), admission CRP levels (ρ=0.620, P<0.001), and admission body temperature (ρ=0.386, P<0.001). Out of 59.30% of positive cultures, one pathogen was isolated in 70.59%, mainly Escherichia coli (41.18%). Admission CRP levels impacted the efficacy of microbiologic isolation (P=0.001). The empirical treatment was mostly based on the clindamycin/gentamicin combination (51.72%). Severe clinical picture that requires surgical treatment can be expected in women >35 years. Longer hospital stay was associated with more symptoms, higher CRP, and temperature values on admission. It is important to have a low threshold for diagnosis and to consider both aerobic and anaerobic pathogens when selecting antibiotic treatment.
{"title":"Characteristics Of Acute Pelvic Inflammatory Disease In Surgically Treated Females Over Ten years - A Single-Center Study","authors":"O. Vasilj, Mateja Vujica Ferenc, A. Šerman, V. Blagaić, Milan Milošević, M. Pavlović, Ivanka Bekavac Vlatković","doi":"10.2174/1573404820666230518103039","DOIUrl":"https://doi.org/10.2174/1573404820666230518103039","url":null,"abstract":"\u0000\u0000Pelvic inflammatory disease (PID) is a public health problem that demands rapid diagnosis and treatment and may severely impair female reproductive health.\u0000\u0000\u0000\u0000To analyze anamnestic information, laboratory findings, and clinical and microbiological features of patients with severe acute PID that underwent a surgical procedure.\u0000\u0000\u0000\u0000This retrospective study enrolled 97 cases that were surgically treated in the Department of Obstetrics and Gynecology, Clinical Hospital „Sveti Duh“ between 2009 and 2019.\u0000\u0000\u0000\u0000Most women were within the age group 35-44 (38.14%). Lower abdominal pain was the most common symptom (92.78%). Compared to intraoperatively confirmed PID, C-reactive protein (CRP) yielded the highest sensitivity (88.10%) while cervical motion tenderness possessed the highest specificity (53.85%). The tubo-ovarian abscess was detected in 35.05% of intraoperative specimens, mainly occurring in women between 45-54 years (P=0.017) and absent between 15-24 (P=0.012) and 25-34 years (P=0.049). The length of hospital stay was influenced by the number of symptoms (ρ=0.316, P=0.002), admission CRP levels (ρ=0.620, P<0.001), and admission body temperature (ρ=0.386, P<0.001). Out of 59.30% of positive cultures, one pathogen was isolated in 70.59%, mainly Escherichia coli (41.18%). Admission CRP levels impacted the efficacy of microbiologic isolation (P=0.001). The empirical treatment was mostly based on the clindamycin/gentamicin combination (51.72%).\u0000\u0000\u0000\u0000Severe clinical picture that requires surgical treatment can be expected in women >35 years. Longer hospital stay was associated with more symptoms, higher CRP, and temperature values on admission. It is important to have a low threshold for diagnosis and to consider both aerobic and anaerobic pathogens when selecting antibiotic treatment.\u0000","PeriodicalId":11030,"journal":{"name":"Current Women s Health Reviews","volume":"438 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76672011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-17DOI: 10.2174/1573404820666230517121653
N. Jahani, M. Hasanzadeh, Sara Mirzaeian, M. Esmaeilpour, M. Farazestanian
Hydatiform mole can progress to gestational trophoblastic neoplasia (GTN), and we are looking for non-invasive methods to predict it. Old age, higher serum BHCG levels, and expression of genes, such as VEGF-EG, HIF-1α, and TGF-ß are known as predictive factors. We performed this study to evaluate the role of bilateral uterine artery doppler ultrasound in predicting postmolar- GTN. In this prospective cohort study, 42 patients with complete molar pregnancy were examined. Inclusion criteria confirmed molar pregnancy by histopathological examination. Exclusion criteria were patients more than 40 years old, patients with completed family childbearing planning, and diagnosis of GTN during the routine histopathological study. Before molar evacuation and four weeks later, bilateral uterine artery doppler sonography to determine the PI, RI, and PSV was performed. Serum BHCG levels were also measured before molar evacuation and weekly after evacuation until it exhibited spontaneous remission or developed GTN. About 36 patients were cured, and six others developed post-molar GTN. The bilateral uterine artery doppler sonography between the two groups showed a lower UA RI in the post-molar-GTN group before evacuation (P=0.048). Data demonstrated significant increases in Right.UA.RI (P=0/008), Left.UA.PI (P=0/037), and Right.UA.PSV (P=0/024) in the spontaneous remission group during 28 days follow-up period. There were no significant differences in these parameters in the GTN group throughout the time of follow-up. It seems that Doppler ultrasound plays a role in predicting GTN following uterine evacuation. A lower resistance in the uterine artery before evacuation and the remaining uterine artery blood flow constant after evacuation is associated with the development of post-molar- GTN.
{"title":"Comparative Investigation of Color Doppler Ultrasonography Parameters\u0000of the Uterine Artery in Patients with Post-molar GTN and Patients Recovered\u0000from Molar Pregnancy and its Role in Predicting the Probability\u0000of Occurrence","authors":"N. Jahani, M. Hasanzadeh, Sara Mirzaeian, M. Esmaeilpour, M. Farazestanian","doi":"10.2174/1573404820666230517121653","DOIUrl":"https://doi.org/10.2174/1573404820666230517121653","url":null,"abstract":"\u0000\u0000Hydatiform mole can progress to gestational trophoblastic neoplasia (GTN),\u0000and we are looking for non-invasive methods to predict it. Old age, higher serum BHCG levels, and\u0000expression of genes, such as VEGF-EG, HIF-1α, and TGF-ß are known as predictive factors. We performed\u0000this study to evaluate the role of bilateral uterine artery doppler ultrasound in predicting postmolar-\u0000GTN.\u0000\u0000\u0000\u0000In this prospective cohort study, 42 patients with complete molar pregnancy were examined.\u0000Inclusion criteria confirmed molar pregnancy by histopathological examination. Exclusion criteria\u0000were patients more than 40 years old, patients with completed family childbearing planning, and diagnosis\u0000of GTN during the routine histopathological study. Before molar evacuation and four weeks later,\u0000bilateral uterine artery doppler sonography to determine the PI, RI, and PSV was performed. Serum\u0000BHCG levels were also measured before molar evacuation and weekly after evacuation until it exhibited\u0000spontaneous remission or developed GTN.\u0000\u0000\u0000\u0000About 36 patients were cured, and six others developed post-molar GTN. The bilateral uterine\u0000artery doppler sonography between the two groups showed a lower UA RI in the post-molar-GTN\u0000group before evacuation (P=0.048). Data demonstrated significant increases in Right.UA.RI\u0000(P=0/008), Left.UA.PI (P=0/037), and Right.UA.PSV (P=0/024) in the spontaneous remission group\u0000during 28 days follow-up period. There were no significant differences in these parameters in the GTN\u0000group throughout the time of follow-up.\u0000\u0000\u0000\u0000It seems that Doppler ultrasound plays a role in predicting GTN following uterine evacuation.\u0000A lower resistance in the uterine artery before evacuation and the remaining uterine artery blood flow constant\u0000after evacuation is associated with the development of post-molar- GTN.\u0000","PeriodicalId":11030,"journal":{"name":"Current Women s Health Reviews","volume":"55 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90096889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-17DOI: 10.2174/1573404820666230517153716
Moghadami Samar, Radnia Nahid, Bakhtiari Mahsa, N. Alimohammadi
Pregnancy and normal vaginal delivery, are the main risk factors for urinary incontinence in women. A variety of treatments such as bladder training and pelvic floor exercises are effective for urinary incontinence. This interventional study has been conducted to compare the influence of Kegel exercises and pelvic floor physiotherapy on the improvements of urge and stress incontinence in women with first or second singleton pregnancies who have experienced normal vaginal delivery. One hundred fifty women with urinary incontinence in the postpartum period, who were divided randomly into 3 groups of 50 patients, participated in this prospective interventional study. The women were primigravida or it was their second labor. None of them complained of urinary incontinence before pregnancy. All of them had a normal vaginal delivery. The first group included females who were asked to perform Kegel exercises. The second group had 8 weekly physiotherapy appointments. The control group, included mothers who received routine care. We compared the prevalence of urge and stress incontinence between groups. We found that the relative risk of urge and stress incontinence among mothers in the control group was more than in the intervention groups, but this difference was only statistically significant in the subject of stress incontinence between the Kegel and control groups. The reduction of urge incontinence prevalence among mothers in the Kegel and physiotherapy groups, was more than control group, although this reduction was not significant. There is a significant decrease in the prevalence of stress urinary incontinence at the end of the 8th and 12th weeks postpartum compared to the control group. Although the prevalence of urge incontinence among women in intervention groups was lower than in the control group, it was not significant. It seems the effect of Kegel exercises and pelvic floor physiotherapy, in reducing stress incontinence at the end of the 8th week, is almost equal.
{"title":"The effect of Kegel exercises and pelvic floor physiotherapy on the improvements of stress urinary incontinence and urge incontinence in women with normal vaginal delivery","authors":"Moghadami Samar, Radnia Nahid, Bakhtiari Mahsa, N. Alimohammadi","doi":"10.2174/1573404820666230517153716","DOIUrl":"https://doi.org/10.2174/1573404820666230517153716","url":null,"abstract":"\u0000\u0000Pregnancy and normal vaginal delivery, are the main risk factors for urinary incontinence in women. A variety of treatments such as bladder training and pelvic floor exercises are effective for urinary incontinence. This interventional study has been conducted to compare the influence of Kegel exercises and pelvic floor physiotherapy on the improvements of urge and stress incontinence in women with first or second singleton pregnancies who have experienced normal vaginal delivery.\u0000\u0000\u0000\u0000One hundred fifty women with urinary incontinence in the postpartum period, who were divided randomly into 3 groups of 50 patients, participated in this prospective interventional study. The women were primigravida or it was their second labor. None of them complained of urinary incontinence before pregnancy. All of them had a normal vaginal delivery. The first group included females who were asked to perform Kegel exercises. The second group had 8 weekly physiotherapy appointments. The control group, included mothers who received routine care. We compared the prevalence of urge and stress incontinence between groups.\u0000\u0000\u0000\u0000We found that the relative risk of urge and stress incontinence among mothers in the control group was more than in the intervention groups, but this difference was only statistically significant in the subject of stress incontinence between the Kegel and control groups. The reduction of urge incontinence prevalence among mothers in the Kegel and physiotherapy groups, was more than control group, although this reduction was not significant.\u0000\u0000\u0000\u0000There is a significant decrease in the prevalence of stress urinary incontinence at the end of the 8th and 12th weeks postpartum compared to the control group. Although the prevalence of urge incontinence among women in intervention groups was lower than in the control group, it was not significant. It seems the effect of Kegel exercises and pelvic floor physiotherapy, in reducing stress incontinence at the end of the 8th week, is almost equal.\u0000","PeriodicalId":11030,"journal":{"name":"Current Women s Health Reviews","volume":"10 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79856786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.2174/1573404820666230228141049
Marjan Mardani-Hamooleh, Haydeh Heidari, Sally Pezaro
Background: Women with breast cancer in Iran face challenges requiring support. Yet the provision of support may have changed during the coronavirus disease 2019 (COVID-19) pandemic. Objective: The aim of the present study was to explore the perceptions of women with breast cancer about the support they received during the COVID-19 pandemic. Methods: This study was qualitative in nature. Semi-structured interviews were conducted with Iranian women with breast cancer. The interviews were transcribed verbatim and analysed via conventional content analysis. Results: Participants (n = 33) were Iranian women aged 29-58 years. All women included were married and were working in the role of a housewife. Women's perceptions of breast cancer during the COVID-19 pandemic of support were identified under two main categories; Constructive support and Lack of support. Sub-categories related to constructive support included receiving support from family, peers, and nurses. Sub-categories related to lack of support included a perceived lack of spousal and sociocultural support. Conclusion: Anti-stigma interventions (AS interventions) are suggested to increase both spousal and sociocultural support in this context. Further studies may usefully be conducted with the participation of Iranian women's family members in order to gain a deeper understanding of the support received and required by Iranian women with breast cancer during the COVID-19 pandemic and beyond.
{"title":"The Perceived Support Received by Women with Breast Cancer during the COVID-19 Pandemic: A Qualitative Study","authors":"Marjan Mardani-Hamooleh, Haydeh Heidari, Sally Pezaro","doi":"10.2174/1573404820666230228141049","DOIUrl":"https://doi.org/10.2174/1573404820666230228141049","url":null,"abstract":"Background: Women with breast cancer in Iran face challenges requiring support. Yet the provision of support may have changed during the coronavirus disease 2019 (COVID-19) pandemic. Objective: The aim of the present study was to explore the perceptions of women with breast cancer about the support they received during the COVID-19 pandemic. Methods: This study was qualitative in nature. Semi-structured interviews were conducted with Iranian women with breast cancer. The interviews were transcribed verbatim and analysed via conventional content analysis. Results: Participants (n = 33) were Iranian women aged 29-58 years. All women included were married and were working in the role of a housewife. Women's perceptions of breast cancer during the COVID-19 pandemic of support were identified under two main categories; Constructive support and Lack of support. Sub-categories related to constructive support included receiving support from family, peers, and nurses. Sub-categories related to lack of support included a perceived lack of spousal and sociocultural support. Conclusion: Anti-stigma interventions (AS interventions) are suggested to increase both spousal and sociocultural support in this context. Further studies may usefully be conducted with the participation of Iranian women's family members in order to gain a deeper understanding of the support received and required by Iranian women with breast cancer during the COVID-19 pandemic and beyond.","PeriodicalId":11030,"journal":{"name":"Current Women s Health Reviews","volume":"246 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135847890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.2174/157340482002230804094223
John Yeh
{"title":"Using Synthetic Biology Technology as an Avenue to Improve Diagnosis and Treatment in Women’s\u0000Health","authors":"John Yeh","doi":"10.2174/157340482002230804094223","DOIUrl":"https://doi.org/10.2174/157340482002230804094223","url":null,"abstract":"<jats:sec>\u0000<jats:title />\u0000<jats:p />\u0000</jats:sec>","PeriodicalId":11030,"journal":{"name":"Current Women s Health Reviews","volume":"42 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77650858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-17DOI: 10.2174/1573404820666230417103148
P. Abedi, Poorandoht Afshari, Maryam Beheshti Nasab, Mitra Tadayon Najafabadi
Since mothers often express higher levels of stress, anxiety and depression, it is important to evaluate the effect of Covid-19 on their mental health during pregnancy and postpartum. The aim of this study was to explore the concerns of mothers in the postpartum period amidst the Covid-19 pandemic This was a descriptive cross-sectional study on 600 postpartum mothers. The sample size was determined based on the households covered by the health centers. The selected mothers completed a demographic questionnaire and Cambridge Worry Scale (CWS). The mean age of study participants was 28.9(6.3)and 364 (60.7%) mothers had excessive anxiety during pregnancy. The highest concern was related to the fear of congestion in the maternity ward with a mean of 2.48, and the lowest level of concern was related to the health status of the mother with a mean of 1.41. we recommend that the health sector adopt new methods of providing care to mothers. Implementation of tests for assessment of the mother's mental state during pregnancy by a midwife consultant is also recommended
{"title":"Maternal worries during the Covid-19 pandemic: A cross-sectional study on postpartum women","authors":"P. Abedi, Poorandoht Afshari, Maryam Beheshti Nasab, Mitra Tadayon Najafabadi","doi":"10.2174/1573404820666230417103148","DOIUrl":"https://doi.org/10.2174/1573404820666230417103148","url":null,"abstract":"\u0000\u0000Since mothers often express higher levels of stress, anxiety and depression, it is important to evaluate the effect of Covid-19 on their mental health during pregnancy and postpartum.\u0000\u0000\u0000\u0000The aim of this study was to explore the concerns of mothers in the postpartum period amidst the Covid-19 pandemic\u0000\u0000\u0000\u0000This was a descriptive cross-sectional study on 600 postpartum mothers. The sample size was determined based on the households covered by the health centers. The selected mothers completed a demographic questionnaire and Cambridge Worry Scale (CWS).\u0000\u0000\u0000\u0000The mean age of study participants was 28.9(6.3)and 364 (60.7%) mothers had excessive anxiety during pregnancy. The highest concern was related to the fear of congestion in the maternity ward with a mean of 2.48, and the lowest level of concern was related to the health status of the mother with a mean of 1.41.\u0000\u0000\u0000\u0000we recommend that the health sector adopt new methods of providing care to mothers. Implementation of tests for assessment of the mother's mental state during pregnancy by a midwife consultant is also recommended\u0000","PeriodicalId":11030,"journal":{"name":"Current Women s Health Reviews","volume":"25 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81148506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-06DOI: 10.2174/1573404820666230406080756
M. Nazari, M. Kaveh, Khadijeh Khademi, L. Ghahremani, M. Karimi
The postpartum period is a challenging time for mothers, in which the quality of life (QOL) is an important indicator of health. Assessing the factors related to postpartum QOL (PQOL) can provide a holistic approach to health programs from an individual to a macro level. This study identified predictive factors for PQOL among Iranian postpartum women. This cross-sectional study was conducted using demographic, obstetric, and PQOL questionnaires on 236 postpartum women. The data were subsequently analyzed using descriptive and analytical statistics. The results identified education level, delivery method (p< 0.05), planned pregnancy, and sufficient family income (p< 0.001) as the four factors associated with PQOL. In addition, adequate family income was identified as a predictor of PQOL (p< 0.001). Given that mothers' health helps to ensure the health of their families and communities, they should be classified according to PQOL predictors and matched with appropriate health programs to provide a high-quality postpartum period.
{"title":"The Predictive Factors of Postpartum Women's Quality of Life: A Cross-Sectional Study in Shiraz, Iran","authors":"M. Nazari, M. Kaveh, Khadijeh Khademi, L. Ghahremani, M. Karimi","doi":"10.2174/1573404820666230406080756","DOIUrl":"https://doi.org/10.2174/1573404820666230406080756","url":null,"abstract":"\u0000\u0000The postpartum period is a challenging time for mothers, in which the quality of life (QOL) is an important indicator of health. Assessing the factors related to postpartum QOL (PQOL) can provide a holistic approach to health programs from an individual to a macro level. This study identified predictive factors for PQOL among Iranian postpartum women.\u0000\u0000\u0000\u0000This cross-sectional study was conducted using demographic, obstetric, and PQOL questionnaires on 236 postpartum women. The data were subsequently analyzed using descriptive and analytical statistics.\u0000\u0000\u0000\u0000The results identified education level, delivery method (p< 0.05), planned pregnancy, and sufficient family income (p< 0.001) as the four factors associated with PQOL. In addition, adequate family income was identified as a predictor of PQOL (p< 0.001).\u0000\u0000\u0000\u0000Given that mothers' health helps to ensure the health of their families and communities, they should be classified according to PQOL predictors and matched with appropriate health programs to provide a high-quality postpartum period.\u0000","PeriodicalId":11030,"journal":{"name":"Current Women s Health Reviews","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82361180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.2174/1573404820666230331115349
D. Herkiloğlu, Sefik Gokce
Although the number of studies conducted among pregnant women with coronavirus (COVID-19) is increasing rapidly, most of the studies are small-scale. Accordingly, data on the relationship between COVID-19 and pregnancy are limited. In addition, there is limited information about which complications COVID-19 causes in pregnant women compared to the normal population, and at what rates. This meta-analysis aimed to examine the data of studies and meta-analyses on pregnancies with COVID-19, and to determine the complication rates caused by COVID-19 in pregnancies. Clinical, observational, or cohort studies published (or epub ahead of print) between January 2020 and December 2021 in any language were scanned in PubMed and Google Scholar. While scanning, the combinations of the terms “COVID-19”, “SARS-CoV-2”, “coronavirus”, “pregnancy”, “PROM”, or “preterm birth” were used. A total of 52 articles and data on 11088 pregnant women were included in the meta-analysis after the screening of 6166 studies. In addition, data belonging to 10 meta-analyses were examined in order to obtain additional information. In the studies covered by this meta-analysis, the rate of premature rupture of membranes was found in 16.8%; preterm birth in 10.3%; low birth weight newborns in 9.2%; maternal or fetal mortality in 3.0%, and other adverse outcomes (fetal distress or abnormal APGAR score, abortion, etc.) in 17.5%. The vertical contamination rate was found to be 2.1%. The findings obtained in this meta-analysis show that COVID-19 significantly increases the maternal or fetal mortality rate in pregnant women and has a negative effect on the preterm birth rate. According to the data we have obtained, COVID-19 also causes the development of some complications, such as fetal distress. The findings also show that COVID-19 is transmitted vertically at a rate of around 2% during pregnancy.
{"title":"COVID-19 and Pregnancy Complications: Meta-Analysis and Systematic Review","authors":"D. Herkiloğlu, Sefik Gokce","doi":"10.2174/1573404820666230331115349","DOIUrl":"https://doi.org/10.2174/1573404820666230331115349","url":null,"abstract":"\u0000\u0000Although the number of studies conducted among pregnant women with coronavirus (COVID-19) is increasing rapidly, most of the studies are small-scale. Accordingly, data on the relationship between COVID-19 and pregnancy are limited. In addition, there is limited information about which complications COVID-19 causes in pregnant women compared to the normal population, and at what rates. This meta-analysis aimed to examine the data of studies and meta-analyses on pregnancies with COVID-19, and to determine the complication rates caused by COVID-19 in pregnancies.\u0000\u0000\u0000\u0000Clinical, observational, or cohort studies published (or epub ahead of print) between January 2020 and December 2021 in any language were scanned in PubMed and Google Scholar. While scanning, the combinations of the terms “COVID-19”, “SARS-CoV-2”, “coronavirus”, “pregnancy”, “PROM”, or “preterm birth” were used.\u0000\u0000\u0000\u0000A total of 52 articles and data on 11088 pregnant women were included in the meta-analysis after the screening of 6166 studies. In addition, data belonging to 10 meta-analyses were examined in order to obtain additional information. In the studies covered by this meta-analysis, the rate of premature rupture of membranes was found in 16.8%; preterm birth in 10.3%; low birth weight newborns in 9.2%; maternal or fetal mortality in 3.0%, and other adverse outcomes (fetal distress or abnormal APGAR score, abortion, etc.) in 17.5%. The vertical contamination rate was found to be 2.1%.\u0000\u0000\u0000\u0000The findings obtained in this meta-analysis show that COVID-19 significantly increases the maternal or fetal mortality rate in pregnant women and has a negative effect on the preterm birth rate. According to the data we have obtained, COVID-19 also causes the development of some complications, such as fetal distress. The findings also show that COVID-19 is transmitted vertically at a rate of around 2% during pregnancy.\u0000","PeriodicalId":11030,"journal":{"name":"Current Women s Health Reviews","volume":"52 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85472307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-30DOI: 10.2174/1573404820666230330104046
Srujana Medithi, Keerthi Vanamala
Leptin hormone is produced by adipose tissue and soluble leptin receptor (sOB-R) influences leptin's free bioavailability. Obese individuals have unusually elevated leptin levels. Obesity influences insulin and other hormone levels and is a key risk factor for developing polycystic ovarian syndrome (PCOS) and mutations such as rs2025804 and G2548A (rs7799039). PCOS is a hormonal condition that affects females of reproductive age primarily. Although there is no known cause of PCOS, studies have linked it to various factors, including insulin resistance, obesity, and genetics. Till now, research indicates a substantial correlation between leptin and female reproductive hormones, and PCOS. Thus, the purpose of this study is to compile the available data for a better understanding of the link between leptin and its effect on female reproductive hormones and PCOS and to determine whether the leptin receptor polymorphism (LEPR) influences the start of PCOS. Following a review of the relevant papers, it was determined that there is an association between leptin and female reproductive hormones such as luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), progesterone, and prolactin. It was observed that Gln223Arg (Q223R/rs1137101), Pro1019Pro (A3057G), Lys109Arg (K109R/rs1147100), rs2025804, and G2548A (rs7799039) are the LEPR polymorphisms associated with PCOS. Gln223Arg is the most frequently studied variant in the LEPR gene across populations. Interestingly, different groups demonstrated varying relationships between leptin receptor polymorphisms and PCOS, particularly for Gln223Arg, which contains two alleles (G allele and A allele). The G allele was protective against PCOS in the Korean population but increased the frequency of PCOS in countries such as Bahrain, India, Iran, and Iraq. There was no significant difference between PCOS and controls with this polymorphism in places such as China, Turkey, Saudi Arabia, and Helsinki. To summarize, the association between multiple leptin receptor polymorphisms and PCOS is complex and varies by research region. There hasn't been much research done on the gene polymorphism "Gln223Arg" or the other polymorphisms. While certain research findings were notable, each came with its limitations. As a result, additional interventional studies, including precise criteria in bigger and more diverse groups, are required.
{"title":"Prospective role of leptin receptor gene and its polymorphisms on the onset of polycystic ovarian syndrome","authors":"Srujana Medithi, Keerthi Vanamala","doi":"10.2174/1573404820666230330104046","DOIUrl":"https://doi.org/10.2174/1573404820666230330104046","url":null,"abstract":"\u0000\u0000Leptin hormone is produced by adipose tissue and soluble leptin receptor (sOB-R) influences leptin's free bioavailability. Obese individuals have unusually elevated leptin levels. Obesity influences insulin and other hormone levels and is a key risk factor for developing polycystic ovarian syndrome (PCOS) and mutations such as rs2025804 and G2548A (rs7799039). PCOS is a hormonal condition that affects females of reproductive age primarily. Although there is no known cause of PCOS, studies have linked it to various factors, including insulin resistance, obesity, and genetics. Till now, research indicates a substantial correlation between leptin and female reproductive hormones, and PCOS. Thus, the purpose of this study is to compile the available data for a better understanding of the link between leptin and its effect on female reproductive hormones and PCOS and to determine whether the leptin receptor polymorphism (LEPR) influences the start of PCOS.\u0000\u0000\u0000\u0000Following a review of the relevant papers, it was determined that there is an association between leptin and female reproductive hormones such as luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), progesterone, and prolactin. It was observed that Gln223Arg (Q223R/rs1137101), Pro1019Pro (A3057G), Lys109Arg (K109R/rs1147100), rs2025804, and G2548A (rs7799039) are the LEPR polymorphisms associated with PCOS. Gln223Arg is the most frequently studied variant in the LEPR gene across populations.\u0000\u0000\u0000\u0000Interestingly, different groups demonstrated varying relationships between leptin receptor polymorphisms and PCOS, particularly for Gln223Arg, which contains two alleles (G allele and A allele). The G allele was protective against PCOS in the Korean population but increased the frequency of PCOS in countries such as Bahrain, India, Iran, and Iraq. There was no significant difference between PCOS and controls with this polymorphism in places such as China, Turkey, Saudi Arabia, and Helsinki.\u0000\u0000\u0000\u0000To summarize, the association between multiple leptin receptor polymorphisms and PCOS is complex and varies by research region. There hasn't been much research done on the gene polymorphism \"Gln223Arg\" or the other polymorphisms. While certain research findings were notable, each came with its limitations. As a result, additional interventional studies, including precise criteria in bigger and more diverse groups, are required.\u0000","PeriodicalId":11030,"journal":{"name":"Current Women s Health Reviews","volume":"41 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75553273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-28DOI: 10.2174/1573404820666230328121709
Youlin Deng, You He, Dan Wang
Ultrasound-guided sclerosis has been used to treat ovarian endometriotic cysts since 1988. However, compared with cystectomy, sclerotherapy's effectiveness and safety are questionable. To compare ultrasound-guided sclerotherapy and ovarian cystectomy in the treatment of ovarian endometriosis through a systematic review and meta-analysis. PubMed-MEDLINE, EMBASE, Cochrane, and Scopus databases were searched, and related literature was collected. The two treatments' recurrence rate, pain relief rate, pregnancy rate, technical success rate, and complication rate were directly compared. Six studies (386 patients) were included. The risk of recurrence with sclerotherapy was higher than that with cystectomy (OR 1.57, p= 0.52). Subgroup analysis showed that an indwelling time > 10 min was not significantly different regarding recurrence risk between sclerotherapy and cystectomy (OR 1.01, p= 0.99). When the indwelling time was ≤ 10 min, the risk of recurrence with sclerotherapy was significantly higher than that with cystectomy (OR 22.01, p= 0.001). The pregnancy rate after cystectomy was lower than that after sclerosis (OR 1.67, p= 0.22). Complications in the study were graded according to the Clavien‒Dindo classification and statistical analysis showed that the probability of serious complications (Grade III-V) with cystectomy was higher than that with sclerosis (16.67% vs. 0%) Ultrasound-guided sclerotherapy was not inferior to cystectomy in terms of recurrence rate or pregnancy rate, and the incidence of severe complications was lower than that in the cystectomy group. Sclerotherapy is a safe and effective alternative treatment for ovarian endometriosis.
{"title":"Comparison of the efficacy and safety of ultrasound-guided sclerotherapy versus cystectomy for the treatment of ovarian endometriomas: a systematic review and meta‑analysis","authors":"Youlin Deng, You He, Dan Wang","doi":"10.2174/1573404820666230328121709","DOIUrl":"https://doi.org/10.2174/1573404820666230328121709","url":null,"abstract":"\u0000\u0000Ultrasound-guided sclerosis has been used to treat ovarian endometriotic\u0000cysts since 1988. However, compared with cystectomy, sclerotherapy's effectiveness and safety are\u0000questionable.\u0000\u0000\u0000\u0000To compare ultrasound-guided sclerotherapy and ovarian cystectomy in the treatment of\u0000ovarian endometriosis through a systematic review and meta-analysis.\u0000\u0000\u0000\u0000PubMed-MEDLINE, EMBASE, Cochrane, and Scopus databases were searched, and related literature was collected. The two treatments' recurrence rate, pain relief rate, pregnancy rate, technical success rate, and complication rate were directly compared.\u0000\u0000\u0000\u0000Six studies (386 patients) were included. The risk of recurrence with sclerotherapy was higher than that with cystectomy (OR 1.57, p= 0.52). Subgroup analysis showed that an indwelling time >\u000010 min was not significantly different regarding recurrence risk between sclerotherapy and cystectomy\u0000(OR 1.01, p= 0.99). When the indwelling time was ≤ 10 min, the risk of recurrence with sclerotherapy\u0000was significantly higher than that with cystectomy (OR 22.01, p= 0.001). The pregnancy rate after\u0000cystectomy was lower than that after sclerosis (OR 1.67, p= 0.22). Complications in the study were\u0000graded according to the Clavien‒Dindo classification and statistical analysis showed that the probability of serious complications (Grade III-V) with cystectomy was higher than that with sclerosis\u0000(16.67% vs. 0%)\u0000\u0000\u0000\u0000Ultrasound-guided sclerotherapy was not inferior to cystectomy in terms of recurrence\u0000rate or pregnancy rate, and the incidence of severe complications was lower than that in the cystectomy group. Sclerotherapy is a safe and effective alternative treatment for ovarian endometriosis.\u0000","PeriodicalId":11030,"journal":{"name":"Current Women s Health Reviews","volume":"31 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82459924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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