Pub Date : 2023-01-01DOI: 10.4103/ds.ds-d-23-00025
Mingling Chen, Shengzhen Ye
Dermatology, as a highly intuitive clinical discipline, requires dermatologists to apply their own knowledge and clinical experience to make a reasonable diagnosis for various skin diseases. However, the diagnosis results are largely affected by the subjective consciousness of dermatologists, and there is a certain misdiagnosis rate, especially in areas with low medical levels. Therefore, there is an urgent need for more accurate, objective, and efficient auxiliary diagnostic tools to improve the diagnostic level of skin diseases. Facing an increasing number of patients and higher requirements for accurate diagnosis of diseases, Artificial Intelligence (AI) technology has attracted considerable attention in the field of dermatology. As a nonorganism, the computer is not affected by subjective consciousness, emotion, fatigue, and other factors in the recognition process. It helps to improve the efficiency of diagnosis and assists human doctors to provide objective and accurate diagnosis results. This paper systematically summarizes the research progress of AI in the diagnosis and application of skin cancers, acne, rosacea, onychomycosis, psoriasis, vitiligo, atopic dermatitis, and eczema diseases at home and abroad in recent years, hoping to help dermatologists have a deeper understanding of AI.
{"title":"The emerging role of Artificial Intelligence in diagnosis and clinical analysis of dermatology","authors":"Mingling Chen, Shengzhen Ye","doi":"10.4103/ds.ds-d-23-00025","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00025","url":null,"abstract":"Dermatology, as a highly intuitive clinical discipline, requires dermatologists to apply their own knowledge and clinical experience to make a reasonable diagnosis for various skin diseases. However, the diagnosis results are largely affected by the subjective consciousness of dermatologists, and there is a certain misdiagnosis rate, especially in areas with low medical levels. Therefore, there is an urgent need for more accurate, objective, and efficient auxiliary diagnostic tools to improve the diagnostic level of skin diseases. Facing an increasing number of patients and higher requirements for accurate diagnosis of diseases, Artificial Intelligence (AI) technology has attracted considerable attention in the field of dermatology. As a nonorganism, the computer is not affected by subjective consciousness, emotion, fatigue, and other factors in the recognition process. It helps to improve the efficiency of diagnosis and assists human doctors to provide objective and accurate diagnosis results. This paper systematically summarizes the research progress of AI in the diagnosis and application of skin cancers, acne, rosacea, onychomycosis, psoriasis, vitiligo, atopic dermatitis, and eczema diseases at home and abroad in recent years, hoping to help dermatologists have a deeper understanding of AI.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135913333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ds.ds-d-22-00120
Yi Wang, Yong Song, Minjian Chen, Zhenni Wei
Background: The pathogenesis of hypertrophic scars (HS) is complex and unclear. It is of great importance to investigate the formation mechanism of HS at the gene level, find new targets for gene therapy, and establish effective prevention strategies for the formation of HS. Objectives: The study explored the expression pattern of HOX transcript antisense intergenic RNA (HOTAIR) and miR-30a-5p in scar tissues of HS patients and investigated their regulatory role in fibroblast function. Methods: Forty HS patients were recruited, and their scar tissues and adjacent normal skin tissues were collected. Fibroblasts were extracted from these tissues. The quantitative reverse transcription–polymerase chain reaction was used for the mRNA measurement. The CCK-8 and transwell assay were applied for cell proliferation and migration assessment. Luciferase reporter assay was done to verify the target gene of HOTAIR. Results: Elevated HOTAIR and decreased miR-30a-5p were measured in both scar tissues and scar fibroblasts, and their levels were negatively correlated. HOTAIR acted as the sponge of miR-30a-5p. HOTAIR knockdown inhibited fibroblast proliferation, migration, and the expression of collagen synthesis-related proteins (procollagen, alpha-smooth muscle actin, and collagen I), but these functions were abolished by miR-30a-5p downregulation. Conclusion: HS patients owned elevated HOTAIR and decreased miR-30a-5p. HOTAIR knockdown can inhibit the proliferation, migration, and collagen synthesis of scar fibroblasts by negatively regulating the expression of miR-30a-5p.
{"title":"HOX transcript antisense intergenic RNA is differentially expressed in hypertrophic scar tissues and regulates the biological function of scar fibroblasts through sponging miR-30a-5p","authors":"Yi Wang, Yong Song, Minjian Chen, Zhenni Wei","doi":"10.4103/ds.ds-d-22-00120","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00120","url":null,"abstract":"Background: The pathogenesis of hypertrophic scars (HS) is complex and unclear. It is of great importance to investigate the formation mechanism of HS at the gene level, find new targets for gene therapy, and establish effective prevention strategies for the formation of HS. Objectives: The study explored the expression pattern of HOX transcript antisense intergenic RNA (HOTAIR) and miR-30a-5p in scar tissues of HS patients and investigated their regulatory role in fibroblast function. Methods: Forty HS patients were recruited, and their scar tissues and adjacent normal skin tissues were collected. Fibroblasts were extracted from these tissues. The quantitative reverse transcription–polymerase chain reaction was used for the mRNA measurement. The CCK-8 and transwell assay were applied for cell proliferation and migration assessment. Luciferase reporter assay was done to verify the target gene of HOTAIR. Results: Elevated HOTAIR and decreased miR-30a-5p were measured in both scar tissues and scar fibroblasts, and their levels were negatively correlated. HOTAIR acted as the sponge of miR-30a-5p. HOTAIR knockdown inhibited fibroblast proliferation, migration, and the expression of collagen synthesis-related proteins (procollagen, alpha-smooth muscle actin, and collagen I), but these functions were abolished by miR-30a-5p downregulation. Conclusion: HS patients owned elevated HOTAIR and decreased miR-30a-5p. HOTAIR knockdown can inhibit the proliferation, migration, and collagen synthesis of scar fibroblasts by negatively regulating the expression of miR-30a-5p.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135913351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ds.ds-d-22-00136
Yuan-Chen Chao, Bor-shen Hu, Connie S Liu, Meng-Sui Lee
{"title":"Breakthrough monkeypox infection in a Taiwanese male with human immunodeficiency virus 6 days after vaccination","authors":"Yuan-Chen Chao, Bor-shen Hu, Connie S Liu, Meng-Sui Lee","doi":"10.4103/ds.ds-d-22-00136","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00136","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91034651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ds.ds-d-22-00159
Yavuz Semiz, Ezgi Aktaş, Sila Aktas, O. Yalçın
{"title":"Multiple hyperkeratotic white papules in a 6-year-old girl: A rare presentation of granuloma annulare","authors":"Yavuz Semiz, Ezgi Aktaş, Sila Aktas, O. Yalçın","doi":"10.4103/ds.ds-d-22-00159","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00159","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79438594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ds.ds-d-22-00209
PatriciaRelatado Solon, BryanEdgar K. Guevara
{"title":"Subcutaneous panniculitis-like T-cell lymphoma presenting as an ulcerated plaque: A case report","authors":"PatriciaRelatado Solon, BryanEdgar K. Guevara","doi":"10.4103/ds.ds-d-22-00209","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00209","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136303331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ds.ds-d-23-00060
Yi-Lu Li, Yi-Han Chang, Cheng-Lin Wu, Hsing-San Yang, Hsin-Yu Huang, Yuan-Ju Lin, J. Hsiao, C. Hsu
{"title":"Successful treatment with everolimus for microcystic lymphangioma of the tongue caused by a somatic PIK3CA mutation","authors":"Yi-Lu Li, Yi-Han Chang, Cheng-Lin Wu, Hsing-San Yang, Hsin-Yu Huang, Yuan-Ju Lin, J. Hsiao, C. Hsu","doi":"10.4103/ds.ds-d-23-00060","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00060","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72512936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ds.ds-d-22-00199
Chun-Sheng Chen, Po-Yuan Wu
{"title":"Poststeroid panniculitis in an 11-month-old boy after rapid cessation of high-dose systemic corticosteroids","authors":"Chun-Sheng Chen, Po-Yuan Wu","doi":"10.4103/ds.ds-d-22-00199","DOIUrl":"https://doi.org/10.4103/ds.ds-d-22-00199","url":null,"abstract":"","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84635327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ds.ds-d-23-00054
ChauYee Ng, Peng-Chieh Shen, Tsung-Fu Tsai, Yi-Jing Lai, Tzu-Li Liu
Vitiligo is the most common acquired pigmentary disorder and can have profound negative psychosocial impacts on patients. The disease course of vitiligo is often unpredictable, and diagnosis and treatment of vitiligo remain a challenging dermatological task. In this review, we touch on new advances in understanding vitiligo pathogenesis; discuss emerging biomarkers that may aid physicians in assessing vitiligo disease activity and severity, and summarize prospective targeted therapies in treating vitiligo. A brief outline dedicated to the impact of the coronavirus disease 2019 pandemic on vitiligo patients is also provided. We hope that readers may acquire a more comprehensive understanding of vitiligo and gain insights into new diagnostic tools and therapeutic options for vitiligo.
{"title":"From zero to one: Recent advances in the pathogenesis, diagnosis, and treatment of vitiligo","authors":"ChauYee Ng, Peng-Chieh Shen, Tsung-Fu Tsai, Yi-Jing Lai, Tzu-Li Liu","doi":"10.4103/ds.ds-d-23-00054","DOIUrl":"https://doi.org/10.4103/ds.ds-d-23-00054","url":null,"abstract":"Vitiligo is the most common acquired pigmentary disorder and can have profound negative psychosocial impacts on patients. The disease course of vitiligo is often unpredictable, and diagnosis and treatment of vitiligo remain a challenging dermatological task. In this review, we touch on new advances in understanding vitiligo pathogenesis; discuss emerging biomarkers that may aid physicians in assessing vitiligo disease activity and severity, and summarize prospective targeted therapies in treating vitiligo. A brief outline dedicated to the impact of the coronavirus disease 2019 pandemic on vitiligo patients is also provided. We hope that readers may acquire a more comprehensive understanding of vitiligo and gain insights into new diagnostic tools and therapeutic options for vitiligo.","PeriodicalId":11107,"journal":{"name":"Dermatologica Sinica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135913566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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