Digestive and Liver Disease最新文献

英文中文

Diagnostic approach to genetically-determined cholestatic liver diseases in adult patients 成年患者基因决定的胆汁淤积性肝病的诊断方法。

IF 3.8 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Digestive and Liver Disease

Pub Date : 2026-01-01 DOI: 10.1016/j.dld.2025.08.088

Toni Herta , Thomas Berg

引用次数: 0

Comment on “Endoscopic features for differentiating sessile serrated lesion with dysplasia or carcinoma in serrated lesions ≥10 mm” 对“≥10mm无柄锯齿状病变与发育不良或癌鉴别的内镜特征”的评论。

IF 3.8 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Digestive and Liver Disease

Pub Date : 2026-01-01 DOI: 10.1016/j.dld.2025.10.007

Shiye Huang, Daquan Liao, Qiao Huang, Xuezheng Zhu, Yubin Feng, Ziye Zhuang

引用次数: 0

Long-term safety of ustekinumab in Crohn’s disease: Descriptive analysis from an observational post-authorisation safety study using I-CARE cohort data ustekinumab治疗克罗恩病的长期安全性：一项使用I-CARE队列数据的授权后观察性安全性研究的描述性分析

IF 3.8 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Digestive and Liver Disease

Pub Date : 2026-01-01 DOI: 10.1016/j.dld.2025.09.026

Laurent Peyrin-Biroulet , Maciej Nazar , Anna Sheahan , Anja Geldhof , Ahlem Azzabi , Filip Baert , Charlotte Mailhat , Hélène Rousseau , Jean-François Rahier , Laurent Beaugerie

Background

Limited data are available from large, prospective cohort studies evaluating the long-term safety of ustekinumab in patients with Crohn’s disease.

Aims

To evaluate the long-term safety profile of ustekinumab in adult patients with Crohn’s disease.

Methods

RRA-20745 was an observational post-authorisation safety study. Data were derived from the I-CARE study (NCT02377258), a European prospective, observational, multi-centre cohort study. Malignancies, serious infections (including opportunistic infections and tuberculosis), and venous thromboembolism associated with hospitalisations were evaluated.

Results

Data for 878 patients with Crohn’s disease who received ustekinumab (mean follow-up 37.8 months), were included (median age 37.4 years, 58.9 % female, 64.5 % incident ustekinumab users and 35.5 % prevalent users). There were 7 malignancies reported in 7 patients (by organ affected: skin, 3 patients [0.4 %], blood, lymph nodes, rectum, breast, 1 patient [0.1 %] each). Serious infections were reported by 16 (1.8 %) patients (6 prevalent users, 10 incident users). The most common serious infections were gastrointestinal (7 patients, 0.8 %), followed by pulmonary infections (3 patients, 0.3 %). 1 patient (0.1 %; prevalent cohort) reported a bacterial opportunistic infection. No patients reported tuberculosis or venous thromboembolism.

Conclusions

In the RRA-20745 observational cohort, ustekinumab had a safety profile consistent with that observed in clinical trials and available post-marketing data.

Trial registration number

NCT02377258.

背景：大型前瞻性队列研究评估ustekinumab治疗克罗恩病患者的长期安全性，数据有限。目的：评估ustekinumab治疗成年克罗恩病患者的长期安全性。方法：RRA-20745是一项批准后的观察性安全性研究。数据来源于I-CARE研究（NCT02377258），这是一项欧洲前瞻性、观察性、多中心队列研究。评估了与住院相关的恶性肿瘤、严重感染（包括机会性感染和结核病）和静脉血栓栓塞。结果：纳入了878例接受ustekinumab治疗的克罗恩病患者（平均随访37.8个月）的数据（中位年龄37.4岁，58.9%为女性，64.5%为ustekinumab患者，35.5%为常见于患者）。7例患者报告7例恶性肿瘤（按受累器官分类：皮肤3例（0.4%），血液、淋巴结、直肠、乳房各1例（0.1%））。16例（1.8%）患者报告了严重感染（6例普遍使用者，10例意外使用者）。最常见的严重感染是胃肠道感染（7例，0.8%），其次是肺部感染（3例，0.3%）。1例患者（0.1%；流行队列）报告细菌性机会性感染。没有患者报告结核或静脉血栓栓塞。结论：在RRA-20745观察性队列中，ustekinumab的安全性与临床试验和现有上市后数据一致。试验注册号：NCT02377258。

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引用次数: 0

Author's Reply: Comment on “A prospective study of duodenal laparoscopy-endoscopy cooperative surgery for superficial duodenal tumors, including periampullary lesions” 作者批复：“十二指肠腹腔镜-内镜联合手术治疗十二指肠浅表性肿瘤包括壶腹周围病变的前瞻性研究”

IF 3.8 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Digestive and Liver Disease

Pub Date : 2026-01-01 DOI: 10.1016/j.dld.2025.10.018

Takaya Shimura, Naomi Sugimura, Hiromi Kataoka

引用次数: 0

24-hour colonic manometry can reveal exaggerated rectosigmoid junction (sphincter of O’Beirne) activity in severely constipated patients 24小时结肠测压可显示严重便秘患者直肠乙状结肠结（O'Beirne括约肌）活动过度。

IF 3.8 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Digestive and Liver Disease

Pub Date : 2026-01-01 DOI: 10.1016/j.dld.2025.10.024

Gabrio Bassotti , Elisabetta Antonelli , Sara Bologna , Ji-Hong Chen , Jan D. Huizinga

引用次数: 0

Empagliflozin might improve chronic inflammatory bowel diseases also in humans 恩格列净也可能改善人类慢性炎症性肠病。

IF 3.8 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Digestive and Liver Disease

Pub Date : 2026-01-01 DOI: 10.1016/j.dld.2025.11.019

Claudio Carallo , Maria Agnese Carallo , Manuela Rosa Spagnolo , Carlo Turi , Stefano Rodinò , Agostino Gnasso

引用次数: 0

Therapeutic approach to genetically-determined cholestatic liver diseases in paediatric and adult patients 儿童和成人患者基因决定的胆汁淤积性肝病的治疗方法。

IF 3.8 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Digestive and Liver Disease

Pub Date : 2026-01-01 DOI: 10.1016/j.dld.2025.11.006

Giuseppe Indolfi , Marianne Samyn

引用次数: 0

Transcultural adaptation and validation of the Italian version of the "Adult eosinophilic esophagitis quality of life questionnaire". 意大利版“成人嗜酸性食管炎生活质量问卷”的跨文化适应和验证。

IF 3.8 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Digestive and Liver Disease

Pub Date : 2025-12-31 DOI: 10.1016/j.dld.2025.12.013

Gennaro Alessio Pirro, Sofia Cuoco, Gianluca Rescigno, Antonella Santonicola, Lucia Landolfi, Edoardo Vincenzo Savarino, Paola Iovino

Background/aims: Eosinophilic esophagitis (EoE) is a chronic type 2-mediated disease that impairs Quality of Life (QoL). Our aim was the transcultural adaptation and validation of the Adult Eosinophilic Esophagitis Quality of Life Questionnaire (EoE-QoL-A) for the Italian population.

Methods: Seventy participants (53 males, >18 years), completed the Italian version translated from the original EoE-QoL-A and validated scales to measure depression, anxiety and QoL. The reliability of total and sub-dimensions' scores, internal consistency, construct validity and test-retest reliability were assessed. The socio-demographic subgroups differences, mood and EoE-QoL-A correlations and the impact of sub-dimensions of EoE-QoL-A on mental and physical QoL were analyzed.

Results: The Italian EoE-QoL-A demonstrated excellent internal consistency (α=0.966), with all sub-dimensions had α-values>0.826 and test-retest reliability (ICC=0.982). Specifically, the Cronbach's α was 0.936 for Eating/diet impact, 0.826 for Social impact, 0.938 for Emotional impact, 0.852 for Disease anxiety, and 0.879 for Choking anxiety. Female patients reported significantly higher EoE-QoL-A than males (p < 0.05). Younger patients showed a higher score in the Social Impact dimension than older patients (p = 0.006). High scores on EoE-QoL-A were linked with high mood symptoms. The Emotional Impact domain was a significant predictor of mental health status (R²=0.418).

Conclusions: The Italian EoE-QoL-A is a valid, reliable and responsive tool for assessing QoL in adults with EoE. Emotional impact was the most affected dimension in the health-related QoL, highlighting the necessity for clinical strategies.

背景/目的：嗜酸性粒细胞性食管炎（EoE）是一种慢性2型介导的疾病，影响生活质量（QoL）。我们的目的是跨文化适应和验证意大利人群的成人嗜酸性食管炎生活质量问卷（EoE-QoL-A）。方法：70名参与者（男性53名，年龄50 ~ 18岁）完成了原EoE-QoL-A的意大利语翻译，并验证了抑郁、焦虑和生活质量的量表。评估了总维度和子维度得分的信度、内部一致性、结构效度和重测信度。分析社会人口学亚组差异、情绪与EoE-QoL-A的相关性以及EoE-QoL-A各子维度对身心生活质量的影响。结果：意大利EoE-QoL-A具有良好的内部一致性（α=0.966），各子维度α值均为>0.826，重测信度（ICC=0.982）。具体而言，进食/饮食影响的Cronbach's α为0.936，社会影响的Cronbach's α为0.826，情绪影响的Cronbach's α为0.938，疾病焦虑的Cronbach's α为0.852，窒息焦虑的Cronbach's α为0.879。女性患者的EoE-QoL-A明显高于男性（p < 0.05）。青年患者社会影响维度得分高于老年患者（p = 0.006）。EoE-QoL-A得分高与高情绪症状有关。情绪影响域是心理健康状况的显著预测因子（R2=0.418）。结论：意大利EoE-QoL- a是评估成人EoE患者生活质量的有效、可靠和反应灵敏的工具。情绪影响是与健康相关的生活质量中受影响最大的维度，这突出了临床策略的必要性。

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引用次数: 0

Virtual Reality-guided radiofrequency ablation for hepatocellular carcinoma: Preoperative three-dimensional visualization for ensuring safer procedure. 虚拟现实引导的肝细胞癌射频消融术：术前三维可视化确保手术更安全。

IF 3.8 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Digestive and Liver Disease

Pub Date : 2025-12-30 DOI: 10.1016/j.dld.2025.12.012

Joji Tani, Daisuke Namima, Ryosuke Kawanishi, Hideki Kobara

引用次数: 0

Diet and clinical remission in patients with inflammatory bowel disease: A multicenter cross-sectional study 炎症性肠病患者的饮食和临床缓解：一项多中心横断面研究

IF 3.8 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Digestive and Liver Disease

Pub Date : 2025-12-30 DOI: 10.1016/j.dld.2025.12.001

Lucile Fontaine , Philippe Seksik , Carmen Stefanescu , Maria Nachury , Stéphane Nancey , Guillaume Savoye , Matthieu Allez , Romain Altwegg , David Laharie , Mélanie Serrero , Denis Franchimont , Nicolas Mathieu , Mathurin Fumery , Lucine Vuitton , Stéphane Nahon , Cyrielle Gilletta , Cléa Rouillon , Alexandre Nuzzo , Arnaud Bourreille , Bénédicte Caron , Sophie Geyl

Background

Diet and risk of developing inflammatory bowel disease (IBD) has been extensively studied.

Aims

To investigate the association between diet and IBD activity.

Methods

Consecutive outpatients in 40 French and Belgian centers completed diet and IBD activity questionnaire between April and May 2023 in a cross-sectional study. Associations between diet and clinical remission were adjusted for gender, age, body mass index, education, smoking, and past CD-surgery.

Results

Among 2514 patients included, 1715 had Crohn’s disease (CD) and 799 had ulcerative colitis (UC). Overall, the mean age was 42.4 years, 52.3 % were women, and 56.4 % were in clinical remission. Among CD patients, clinical remission was associated with a higher intake of fruits (aOR 1.60 [1.20–2.14]) and coffee (aOR 1.57 [1.17–2.11]). Among UC patients, clinical remission was associated with a higher intake of fruits (aOR 1.72 [1.15–2.56]) and salad (aOR 1.73 [1.12–2.66]). A higher adherence to a Mediterranean diet was associated with CD (aOR 1.39 [1.06–1.84]) but not UC remission. A higher adherence to a healthy diet was not associated with either CD nor UC remission.

Conclusions

CD remission was associated with higher intakes of fruits, coffee and a Mediterranean diet, while UC remission was associated with higher intakes of fruits and salad. As this was a cross-sectional study, the main limitation was the possibility of reverse causality.

背景：饮食与炎症性肠病（IBD）发病风险的关系已被广泛研究。目的：探讨饮食与IBD活动之间的关系。方法：在横断面研究中，在2023年4月至5月期间，40个法国和比利时中心的连续门诊患者完成了饮食和IBD活动问卷调查。饮食与临床缓解之间的关系根据性别、年龄、体重指数、教育程度、吸烟和既往cd手术进行了调整。结果：2514例患者中，1715例为克罗恩病（CD）， 799例为溃疡性结肠炎（UC）。总体而言，平均年龄为42.4岁，52.3%为女性，56.4%临床缓解。在CD患者中，临床缓解与摄入更多水果（aOR为1.60[1.20-2.14]）和咖啡（aOR为1.57[1.17-2.11]）有关。在UC患者中，临床缓解与摄入更多水果（aOR为1.72[1.15-2.56]）和沙拉（aOR为1.73[1.12-2.66]）有关。较高的地中海饮食依从性与CD （aOR 1.39[1.06-1.84]）相关，但与UC缓解无关。较高的健康饮食依从性与CD和UC的缓解无关。结论：乳糜泻缓解与摄入更多水果、咖啡和地中海饮食有关，而UC缓解与摄入更多水果和沙拉有关。由于这是一项横断面研究，主要的限制是反向因果关系的可能性。

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