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ADHD medication shortages: more than just a supply issue. 多动症药物短缺：不仅仅是供应问题。
Q4 Medicine
Drug and Therapeutics Bulletin
Pub Date : 2024-01-30 DOI: 10.1136/dtb.2023.000062
Alexandra Lewis, Teck K Khong
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引用次数: 0
Can antidepressants worsen COPD? 抗抑郁药会加重慢性阻塞性肺病吗？
Q4 Medicine
Drug and Therapeutics Bulletin
Pub Date : 2024-01-30 DOI: 10.1136/dtb.2024.000002

Overview of: Siraj RA, Bolton CE, McKeever TM. Association between antidepressants with pneumonia and exacerbation in patients with COPD: a self-controlled case series (SCCS). Thorax. 2023. doi:10.1136/thorax-2022-219736 [Epub ahead of print 19 June 2023].

概述：Siraj RA、Bolton CE、McKeever TM。抗抑郁药与慢性阻塞性肺病患者肺炎和病情加重之间的关系：自控病例系列（SCCS）。Thorax.2023. doi:10.1136/thorax-2022-219736 [Epub ahead of print 19 June 2023].
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引用次数: 0
Risk of recurrence after first unprovoked seizure. 首次无诱因癫痫发作后的复发风险。
Q4 Medicine
Drug and Therapeutics Bulletin
Pub Date : 2024-01-30 DOI: 10.1136/dtb.2024.000006

Overview of: Neligan A, Adan G, Nevitt SJ, et al. Prognosis of adults and children following a first unprovoked seizure. Cochrane Database Syst Rev. 2023:10.1002/14651858.CD013847.pub2.

概述：Neligan A, Adan G, Nevitt SJ, et al. 首次无诱因癫痫发作后成人和儿童的预后。Cochrane Database Syst Rev. 2023:10.1002/14651858.CD013847.pub2。
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引用次数: 0
Low-dose aspirin and anaemia in older people. 低剂量阿司匹林与老年人贫血。
Q4 Medicine
Drug and Therapeutics Bulletin
Pub Date : 2024-01-30 DOI: 10.1136/dtb.2024.000001

Overview of: McQuilten ZK, Thao LTP, Pasricha SR, et al. Effect of low-dose aspirin versus placebo on incidence of anemia in the elderly: a secondary analysis of the aspirin in reducing events in the elderly trial. Ann Intern Med. 2023;176:913-21.

概述：McQuilten ZK、Thao LTP、Pasricha SR 等：低剂量阿司匹林与安慰剂对老年人贫血发生率的影响：阿司匹林减少老年人贫血试验的二次分析。Ann Intern Med.2023;176:913-21.
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引用次数: 0
Managing acne vulgaris: an update 管理寻常痤疮：最新进展
Q4 Medicine
Drug and Therapeutics Bulletin
Pub Date : 2024-01-01 DOI: 10.1136/dtb.2023.000051
Miriam Santer, Esther Burden-Teh, Jane Ravenscroft
Acne vulgaris is very common and can have significant negative impact on people. While sometimes a transient problem, acne may persist for many years and often leads to permanent scars or pigment changes. Guidelines unanimously advise topical treatments as first-line, although differ in recommending either topical benzoyl peroxide or topical retinoid (mainly adapalene) alone or in combination. Guidance published by the National Institute for Health and Care Excellence advises counselling patients regarding avoidance of skin irritation when starting topical treatments and promoting adherence (treatments take 6–8 weeks to work). Oral antibiotics are currently overprescribed for acne but have a role when coprescribed with a non-antibiotic topical treatment. Hormonal treatments, such as the combined contraceptive pill, are also effective and there is growing evidence for the use of spironolactone for women with persistent acne. Recent guidance from the Medicines and Healthcare products Regulatory Agency regarding isotretinoin has implications for specialist prescribing and monitoring, and increasing public awareness of potential risks of mental health problems and sexual dysfunction. Although acne is associated with psychiatric disorder, the mental health effects of isotretinoin remain controversial.
寻常痤疮很常见，会对人造成很大的负面影响。痤疮有时只是一过性的问题，但可能会持续多年，并常常导致永久性疤痕或色素改变。指南一致建议将外用治疗作为第一线治疗方法，但在建议外用过氧化苯甲酰或外用维甲酸（主要是阿达帕林）单独或联合使用方面存在差异。美国国家健康与护理卓越研究所发布的指南建议，在开始局部治疗时，应指导患者避免刺激皮肤，并促进患者坚持治疗（治疗需要 6-8 周才能见效）。目前，口服抗生素治疗痤疮的处方过多，但如果与非抗生素外用疗法同时使用，口服抗生素还是有一定作用的。荷尔蒙治疗，如联合避孕药，也很有效，而且越来越多的证据表明，螺内酯可用于治疗女性顽固性痤疮。最近，药品和保健品监管局发布了关于异维A酸的指南，这对专业处方和监测产生了影响，并提高了公众对精神健康问题和性功能障碍潜在风险的认识。虽然痤疮与精神障碍有关，但异维A酸对精神健康的影响仍存在争议。
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引用次数: 0
Changes in primary endpoints in cancer trials. 癌症试验主要终点的变化。
Q4 Medicine
Drug and Therapeutics Bulletin
Pub Date : 2023-12-27 DOI: 10.1136/dtb.2023.000064

Overview of: Florez MA, Jaoude JA, Patel RR, et al. Incidence of primary end point changes among active cancer phase 3 randomized clinical trials.JAMA Netw Open2023;6:e2313819.

概述：Florez MA, Jaoude JA, Patel RR, et al. Inidence of primary end point changes among active cancer phase 3 randomized clinical trials.JAMA Netw Open2023;6:e2313819.
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引用次数: 0
Continuity of care: good for patients, good for prescribing. 护理的连续性:对病人有利，对处方有利。
Q4 Medicine
Drug and Therapeutics Bulletin
Pub Date : 2023-12-27 DOI: 10.1136/dtb.2023.000033
Julian Treadwell
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引用次数: 0
Safety update: statins and myasthenia gravis. 安全更新:他汀类药物和重症肌无力。
Q4 Medicine
Drug and Therapeutics Bulletin
Pub Date : 2023-12-27 DOI: 10.1136/dtb.2023.000063

Overview of: Medicines and Healthcare products Regulatory Agency. Statins: very infrequent reports of myasthenia gravis.Drug Safety Update 2023;17(2):1.

概述：药品和保健品管理局。他汀类药物：关于肌无力的极少数报告.药物安全更新 2023；17（2）：1.
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引用次数: 0
SGLT2 inhibitor associated euglycaemic diabetic ketoacidosis in an orthopaedic trauma patient. 一名骨科创伤患者因服用 SGLT2 抑制剂而出现优生糖尿病酮症酸中毒。
Q4 Medicine
Drug and Therapeutics Bulletin
Pub Date : 2023-12-27 DOI: 10.1136/dtb.2023.250233rep
Duncan Taylor Ritchie, James Dixon
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引用次数: 0
Hydrocortisone for severe community acquired pneumonia in ICU. 氢化可的松治疗重症社区获得性肺炎。
Q4 Medicine
Drug and Therapeutics Bulletin
Pub Date : 2023-12-27 DOI: 10.1136/dtb.2023.000057

Overview of:Dequin PF, Meziani F, Quenot JP, et al. Hydrocortisone in severe community-acquired pneumonia. N Engl J Med 2023;388:1931-41.

概述：Dequin PF、Meziani F、Quenot JP 等：氢化可的松在重症社区获得性肺炎中的应用。N Engl J Med 2023;388:1931-41.
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引用次数: 0
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