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Donanemab in early symptomatic Alzheimer’s disease 多奈单抗治疗早期症状阿尔茨海默病
Q4 Medicine
Drug and Therapeutics Bulletin
Pub Date : 2024-04-05 DOI: 10.1136/dtb.2024.000020
BMJ Publishing Group Ltd
### Key learning points The authors of a phase 3 trial involving people with early Alzheimer’s disease (AD) reported that although donanemab produced a small reduction in clinical progression compared with placebo, it was associated with some serious adverse effects.1 The TRAILBLAZER-ALZ 2 trial was a 76-week, phase 3, randomised, double-blind, placebo-controlled study that recruited participants aged 60–85 years with early symptomatic AD, a Mini-Mental State Examination score of 20–28 and confirmed amyloid and tau pathology assessed by positron emission tomography (PET) scans.1 A total of 1736 …
###学习要点 一项涉及早期阿尔茨海默病（AD）患者的 3 期试验的作者报告说，与安慰剂相比，虽然多那尼单抗能使临床进展略有减少，但它与一些严重的不良反应有关。TRAILBLAZER-ALZ 2 试验是一项为期 76 周的第 3 期随机、双盲、安慰剂对照研究，招募的参与者年龄在 60-85 岁之间，患有早期症状性阿尔茨海默病，迷你精神状态检查评分为 20-28 分，正电子发射断层扫描（PET）评估证实了淀粉样蛋白和 tau 病理学。
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引用次数: 0
Do regulatory safety warnings on medicines miss the mark? 药品的监管安全警告是否失误？
Q4 Medicine
Drug and Therapeutics Bulletin
Pub Date : 2024-03-25 DOI: 10.1136/dtb.2023.000053
Barbara Mintzes
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引用次数: 0
Safety update: valproate safety and educational materials. 安全性更新：丙戊酸钠的安全性和教育材料。
Q4 Medicine
Drug and Therapeutics Bulletin
Pub Date : 2024-03-25 DOI: 10.1136/dtb.2024.000013

Overview of: Medicines and Healthcare products Regulatory Agency. Valproate (Belvo, Convulex, Depakote, Dyzantil, Epilim, Epilim Chrono or Chronosphere, Episenta, Epival and Syonell▼): new safety and educational materials to support regulatory measures in men and women under 55 years of age. Drug Safety Update 2024;17:1.

概述：药品和保健品监管局。丙戊酸钠（Belvo、Convulex、Depakote、Dyzantil、Epilim、Epilim Chrono或Chronosphere、Episenta、Epival和Syonell▼）：支持55岁以下男性和女性监管措施的新安全和教育材料。药物安全更新 2024；17:1。
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引用次数: 0
Does oseltamivir prevent hospitalisation in people with influenza? 奥司他韦能否预防流感患者住院？
Q4 Medicine
Drug and Therapeutics Bulletin
Pub Date : 2024-03-25 DOI: 10.1136/dtb.2024.000016

Overview of: Hanula R, Bortolussi-Courval É, Mendel A, et al. Evaluation of oseltamivir used to prevent hospitalization in outpatients with influenza: a systematic review and meta-analysis. JAMA Internal Medicine 2024;184:18-27.

概述：Hanula R、Bortolussi-Courval É、Mendel A 等人。 用于预防门诊流感患者住院的奥司他韦评估：系统综述和荟萃分析。美国医学会杂志内科学》2024;184:18-27。
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引用次数: 0
Effect of topical testosterone on pre-diabetes and diabetes. 局部睾酮对糖尿病前期和糖尿病的影响。
Q4 Medicine
Drug and Therapeutics Bulletin
Pub Date : 2024-03-25 DOI: 10.1136/dtb.2024.000017

Overview of: Bhasin S, Lincoff AM, Nissen SE, et al. Effect of testosterone on progression from prediabetes to diabetes in men with hypogonadism: a substudy of the TRAVERSE randomized clinical trial. JAMA Intern Med. 2024. doi: 10.1001/jamainternmed.2023.7862. [Epub ahead of print 5 February 2024].

概述：Bhasin S、Lincoff AM、Nissen SE 等：睾酮对男性性腺功能减退症患者从糖尿病前期发展为糖尿病的影响：TRAVERSE 随机临床试验的子研究。JAMA Intern Med.DOI: 10.1001/jamainternmed.2023.7862。[Epub ahead of print 5 February 2024].
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引用次数: 0
Use of oral penicillin challenge in low-risk penicillin allergy. 在低风险青霉素过敏症中使用口服青霉素挑战。
Q4 Medicine
Drug and Therapeutics Bulletin
Pub Date : 2024-03-25 DOI: 10.1136/dtb.2024.000015

Overview of: Copaescu AM, Vogrin S, James F, et al. Efficacy of a clinical decision rule to enable direct oral challenge in patients with low-risk penicillin allergy: The PALACE randomized clinical trial. JAMA Intern Med 2023;183:944-52.

概述：Copaescu AM、Vogrin S、James F 等人.低风险青霉素过敏患者直接口服青霉素的临床决策规则疗效：PALACE 随机临床试验》。JAMA Intern Med 2023;183:944-52.
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引用次数: 0
Slynd: does a drospirenone progestogen-only pill offer an advantage? Slynd：仅使用屈螺酮孕激素的避孕药有优势吗？
Q4 Medicine
Drug and Therapeutics Bulletin
Pub Date : 2024-03-25 DOI: 10.1136/dtb.2023.000065
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引用次数: 0
Protecting consumers: a rich legacy. 保护消费者：丰富的遗产。
Q4 Medicine
Drug and Therapeutics Bulletin
Pub Date : 2024-02-28 DOI: 10.1136/dtb.2024.000012
David Phizackerley
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引用次数: 0
Safety update: omega-3-acid ethyl esters and atrial fibrillation. 安全性更新：欧米茄-3-酸乙酯与心房颤动。
Q4 Medicine
Drug and Therapeutics Bulletin
Pub Date : 2024-02-28 DOI: 10.1136/dtb.2024.000010

Overview of: Medicines and Healthcare products Regulatory Agency. Omega-3-acid ethyl ester medicines (Omacor/Teromeg 1000 mg capsules): dose-dependent increased risk of atrial fibrillation in patients with established cardiovascular diseases or cardiovascular risk factors. Drug Safety Update 2024;17(6):3.

概述：药品和保健品监管局。欧米伽-3 酸乙酯药物（Omacor/Teromeg 1000 毫克胶囊）：剂量依赖性增加既有心血管疾病或心血管风险因素患者的心房颤动风险。药物安全最新信息 2024；17（6）：3。
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引用次数: 0
Acute liver failure secondary to therapeutic paracetamol dosing in an extremely preterm neonate. 一名极早产新生儿因服用治疗性扑热息痛而继发急性肝功能衰竭。
Q4 Medicine
Drug and Therapeutics Bulletin
Pub Date : 2024-02-28 DOI: 10.1136/dtb.2023.245406rep
Krishna Raghu, Mary Judith Berry
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引用次数: 0
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