Dermatologic Surgery最新文献

Background: Poly-l-lactic acid (PLLA-SCA) can be used to improve the aesthetics of the temporal fossae but is usually only deposited within the visible area of the temporal hollows. However, extending the treatment area posterior to the hairline may provide a greater lifting effect.

Objectives: Assess the efficacy and safety of 2 techniques (traditional vs extended) of injecting PLLA-SCA for aesthetic improvement of the temporal fossae.

Materials and methods: A prospective, randomized-controlled clinical trial was conducted. Twenty-four subjects were randomized in a 1-to-1 ratio to the traditional or extended injection technique. Subjects received 3 treatments (Baseline, Week 7, Week 14) and were evaluated for follow-up at Weeks 20, 26, and 38. Assessments included the Global Aesthetic Improvement Scale (GAIS), Temple Volume Deficit Scale (TVDS), lifting and volumizing effects, subject satisfaction, and adverse events.

Results: A greater facial lifting effect (p < .001) and mean decrease in TVDS scores were observed with the extended injection technique. Regardless of injection technique, all subjects were at least improved on the GAIS at Week 38, and there was a low frequency of adverse events.

Conclusion: Poly-l-lactic acid is a safe and effective treatment for improving the aesthetic appearance of the temporal fossae. Outcomes can be maximized using an extended injection technique.

Background: Hair follicle (HF) transplantation, especially through follicular unit excision (FUE), is renowned for treating androgenetic alopecia. Recent advancements have expanded its use in dermatology and plastic surgery.

Objective: This review explores FUE's broader applications beyond hair restoration, including its efficacy in treating chronic ulcers, axillary hyperhidrosis, bromhidrosis, vitiligo, and scar remodeling.

Methods: A comprehensive literature review was conducted using key medical databases, focusing on clinical research such as randomized controlled trials, retrospective studies, case series, and reports, while excluding review articles and commentaries.

Results: Hair follicle transplantation using the FUE technique has shown significant promise in enhancing healing in chronic ulcers and difficult to heal wounds, with cases demonstrating complete wound healing across various ulcer types. The method of sweat gland removal using FUE micropunches substantially reduced sweating and malodor in patients with axillary hyperhidrosis and bromhidrosis. In vitiligo treatment, FUE combined with other therapies showed promising repigmentation results.

Conclusion: Follicular unit excision emerges as a versatile surgical technique demonstrating potential in various conditions beyond alopecia. The minimal complications associated with FUE across various applications highlight its safety profile. Its expanding scope in medical applications calls for further research and clinical trials to optimize its use and understand its full therapeutic potential.

Background: In 1817 and 1820, the German physician Justinus Kerner published a series of cases of lethal food poisoning that would unknowingly have a lasting impact on medical science. His compilation of over 75 cases linked the consumption of smoked sausages in the small town of Herrenberg in Württemberg, recounted a constellation of symptoms that today the authors call botulism. Now, over 2 centuries later, the discovery, study and refinement of the toxin causing clinical botulism has led to the acceptance of neuromodulators as a treatment for a wide variety of medical concerns.

Objective: The aim of this article is to understand the many historical advances in the mechanism of action of botulinum neurotoxins, the wide range of indications that are currently available and Dermatologic Surgery's role in this evolution.

Materials and methods: A PubMed retrospective search to identify literature on the history of botulinum toxin was undertaken.

Results: Botulinum toxin is the newest therapeutic generational drug with over 30 approved indications in 90 countries. There are now 7 FDA (food and drug administration) approved neuromodulators with several more under current review. CONCLUSIONDermatologic Surgery has had a seminal role in the advancement of neuromodulators and publishing associated literature.

Background: Cryolipolysis is a safe, effective, and noninvasive treatment for subcutaneous fat reduction.

Objective: Assess safety, effectiveness, and participant satisfaction with multiple simultaneous dual-applicator cryolipolysis treatments on the torso.

Materials and methods: Adult participants received multiple simultaneous treatments to the torso (i.e., flanks, abdomen, back/bra area). Primary effectiveness end point was ≥70% correct identification of baseline versus week 12 post-final treatment photographs by ≥2 of 3 independent reviewers; safety end point was frequency of adverse device effects (ADEs). Secondary end points included fat layer thickness reduction and participant satisfaction/comfort.

Results: Mean participant age (N = 35) was 40.4 years, 77.1% were female, and mean body mass index was 24.9 kg/m2. A mean of 20.8 treatment cycles were received over 2 treatment sessions. The primary effectiveness end point was met; 75% of pretreatment images were correctly identified. Mean reduction in fat layer thickness was 0.33 cm. Most ADEs were mild, with no serious events. Mean overall participant satisfaction with the procedure was 82.8%. Mean maximum pain scores were 2.6 and 4.1 (scale of 10) during treatment sessions 1 and 2, respectively.

Conclusion: Multiple simultaneous cryolipolysis treatments on the torso using a dual-applicator system were safe and effective, with high overall participant satisfaction.