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A habit of raw farm animal blood consumption and public awareness about associated health risks in Konso district 孔索地区食用农场动物生血的习惯和公众对相关健康风险的认识
Pub Date : 2018-11-16 DOI: 10.15406/MOJAP.2018.05.00224
Getachew Gezehagn Kussia, Alemu Aylate Ayano
In Ethiopia the habit of consuming fresh meat locally in the form of Kurt and or kitifo is very common and thus community of the study area have a similar cultural value towards consumption of raw meat or blood. However, as most of food animals in the area are slaughtered without any veterinary supervision especially in the backyard of some ‘‘cheka’’ groceries with in the villages, where animals are slaughtered without any routine inspection methods in the poor hygienic slaughtering yards.3
在埃塞俄比亚,以Kurt和/或kitifo的形式消费当地鲜肉的习惯非常普遍,因此研究区域的社区对生肉或生血的消费具有类似的文化价值。然而,由于该地区大部分食用动物在没有任何兽医监督的情况下屠宰,特别是在农村一些“契卡”食品杂货店的后院,在卫生条件差的屠宰场,没有任何常规检查方法
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引用次数: 0
Age dynamics of cerebral blood flow velocity in orthopedic diseases and fractures of limb bones 骨科疾病及肢体骨折患者脑血流速度的年龄动态变化
Pub Date : 2018-11-15 DOI: 10.15406/mojap.2018.05.00222
Schurov Va, Novicov Ki, Muradisinov So
With increasing age comes the slowing of blood flow through the arteries of the brain.1–5 It is shown that at the same time, the elderly (419) was a slowdown in the speed of locomotion.6 When the pathology of the musculoskeletal system age-related decline rate of cerebral blood flow velocity are relatively higher.7,8 With increasing age, decreased as the maximum permissible values of the operational elongation according to the Ilizarov method stunting of the limbs and the length of the period of fixing broken bones.9,10
随着年龄的增长,通过大脑动脉的血液流动减慢。结果表明,与此同时,老年人(419)的运动速度减慢了当肌肉骨骼系统病变时,与年龄相关的脑血流速度下降率都相对较高。根据Ilizarov方法,随着年龄的增长,肢体发育迟缓和骨折固定时间的最长允许伸长率随年龄的增加而降低
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引用次数: 0
Pharmacological evaluation of Portulaca quadrifida 马齿苋的药理评价
Pub Date : 2018-11-02 DOI: 10.15406/MOJAP.2018.05.00221
R. Vanga, Y SrujanaChaitanya, Jyothi Kanaparthi
The leaves of ‘Portulaca quadrifida’13,14 were collected in the month of March 2013 from the chilli fields of Mulkanoor, Karimnagar, AP, India. The plant was taxonomically identified by Dr. Musthafa, botanist, Kakatiya University, Warangal, AP, India. The leaves were dried under shade and then powdered with a mechanical grinder. The powder was passed through sieve No#40 and stored in airtight container for future use.
“Portulaca quadriida”13,14的叶子是在2013年3月从印度AP Karimnagar的Mulkanoor辣椒地里收集的。该植物由印度美联社瓦朗加尔Kakatiya大学植物学家Musthafa博士进行分类鉴定。树叶在阴凉处晒干,然后用机械研磨机磨成粉末。粉末通过40号筛,储存在密闭容器中备用。
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引用次数: 2
Descriptive anatomy of artery of one-humped camel head (Camelus dromedarius) 单峰骆驼头动脉描述性解剖
Pub Date : 2018-10-23 DOI: 10.15406/MOJAP.2018.05.00220
H. Jerbi, W. Pérez
Figure 1 Arteries of the head (Superficiel layer, lateral view). 1M. sternocephalicus, 2A. carotis communis, 3R. musculares, 4A. thyroideus media, 5A. thyroidea cranialis, 6Glandulae mandibularis, 7A. auricularis caudalis, 8A. transversa faciei, 9A. facialis, 10A. facialis, rami dorsalis, 11A. facialis, rami ventralis, 12Nervi facialis, rami dorsalis, 13Nervi facialis, rami ventralis, 14Nervi transversus faciei, 15A. labialis inferior, 16R. mentales, 17M. masseter, 18M. malaris, 19Glandulae salivariae. At the level of the axis, it gives off ventrally, the cranial thyroid artery to the cranial part of the thyroid gland, the middle thyroid artery to the middle part of the thyroid gland, and dorsally, the occipital artery which passes through the foramen alare and anastomoses with the vertebral artery (Figure 2) (Figure 3). Under the wing of the atlas, the common carotid artery is continued by the external carotid artery (Figure 2) (Figure 4).
图1头部动脉(侧面浅层)。1米。sternocephalicus, 2。cartis communis, 3R。肌肉,4。甲状腺中肌,5A。甲状颅骨,6,下颌骨腺,7A。尾耳肌,8A。面对面,9A。面神经,10。面肌,背支,11A。面神经,腹支,12面神经,背支,13面神经,腹支,14面横神经,15A。下唇肌,16R。精神,17米。咬肌,18米。疟疾,19唾液腺科。在椎轴水平向腹侧出甲颅动脉至甲状腺颅部,向甲状腺中动脉至甲状腺中部,向背侧出经枢椎孔与椎动脉吻合的枕动脉(图2)(图3)。寰椎翼下颈总动脉由颈外动脉接续(图2)(图4)。
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引用次数: 3
IVF with donor eggs over 40 and other health issues impacting IVF success rates 捐赠卵子超过40岁的试管婴儿和其他影响试管婴儿成功率的健康问题
Pub Date : 2018-10-22 DOI: 10.15406/MOJAP.2018.05.00219
B. Becker
IVF and Hydrosalpinx is a medical term for the condition of blocked fallopian tube(s) and fluid in the tubes. It does impact the health status of the IVF patient. Many studies show that blocked fallopian tubes are associated with poor outcome as far as IVF fertilization is concerned.1 According to dr Uljana Dorofeyeva, in the case of IVF with donor eggs it recommended to have the Hydrosalpinx removed. The presence of hydrosalpinx can impede fertility in several ways. On a simple biomechanical level, when a tube is blocked by fluid and swelling, the egg cannot travel through and sperm are unable to move normally to meet the egg for fertilization. Even if only one tube is affected, the tubal fluid from that tube may accumulate in the uterus and prevent implantation of embryos or be toxic to the embryo. Generally speaking, medical professionals refrain from performing an embryo transfer before blocked fallopian tubes are removed via laparoscopy.
试管婴儿和输卵管积水是一个医学术语,指的是输卵管阻塞和管内液体。它确实会影响试管婴儿患者的健康状况。许多研究表明,输卵管阻塞与IVF受精的不良结果有关根据Uljana Dorofeyeva医生的说法,在使用捐赠卵子进行体外受精的情况下,建议切除输卵管积水。输卵管积水的存在可以在几个方面阻碍生育。在简单的生物力学层面上,当输卵管被液体堵塞和肿胀时,卵子无法通过,精子也无法正常移动以与卵子相遇并受精。即使只有一根输卵管受到影响,从那根输卵管流出的输卵管液也可能积聚在子宫内,阻止胚胎着床或对胚胎有毒。一般来说,在通过腹腔镜切除阻塞的输卵管之前,医学专业人员不会进行胚胎移植。
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引用次数: 0
Congenital tracheoesophageal, umbilical, vascular and meningeal fistulas 先天性气管、食管、脐、血管及脑膜瘘
Pub Date : 2018-10-12 DOI: 10.15406/MOJAP.2018.05.00218
Heshmat S W Haroun
Esophageal atresia (EA) is a rare congenital anomaly (1:25004500 live births) which is most frequently associated with tracheoesophageal fistula (TEF). TEF and EA are two components of VACTERL association of congenital anomalies: “V” for vertebral or vascular anomalies, “A” for anal atresia, “C” for cardiac abnormalities, “T” for tracheoesophageal fistula, “E” for esophageal atresia, “R” for renal abnormalities, and “L” for limb anomalies.2,3 VACTERL is an association rather than a syndrome as its components are not pathologically caused but embryologically formed due to mesodermal defects.4 When at least two5 or three6,7 components of these congenital anomalies are identified in the same neonate, VACTERL association is diagnosed. Patients with EA most likely suffer from gastroesophageal reflux disease (GERD).8
食管闭锁(EA)是一种罕见的先天性异常(1:25004500活产),最常与气管食管瘘(TEF)相关。TEF和EA是先天性异常VACTERL关联的两个组成部分:“V”表示椎体或血管异常,“A”表示肛门闭锁,“C”表示心脏异常,“T”表示气管食管瘘,“E”表示食管闭锁,“R”表示肾脏异常,“L”表示肢体异常。2,3 VACTERL是一种关联而不是综合征,因为其成分不是病理引起的,而是由于中胚层缺陷而在胚胎学上形成的当在同一新生儿中发现这些先天性异常的至少两个或三个组成部分时,诊断为VACTERL关联。EA患者最可能患有胃食管反流病(GERD)
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引用次数: 0
Genetic and chemically-induced Zebrafish models for the study of diabetes mellitus 遗传和化学诱导的斑马鱼糖尿病模型的研究
Pub Date : 2018-10-09 DOI: 10.15406/mojap.2018.05.00217
M. P. Sarras Jr.
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引用次数: 1
Genetic and chemically-induced Zebrafish models for the study of diabetes mellitus 遗传和化学诱导的斑马鱼糖尿病模型的研究
Pub Date : 2018-10-09 DOI: 10.15406/mojap.2018.5.00217
M. Sarras
Diabetes mellitus (DM) will likely affect over 400 million worldwide by 20301 and is classified as a disease of metabolic dysfunction related to the homeostasis of systemic glucose levels [e.g. elevated glucose levels or what is termed hyperglycemia (HG)].2,3 DM can be subdivided into type-1 DM and type-2 DM. In type-1 DM the ability of insulin to be produced is impaired while in type-2 DM, the ability of the body to respond to insulin is impaired. While management of systemic glucose levels is essential to the health of the patient, the long term secondary complications of diabetes poses an equally critical problem. In this regard, data from the laboratory4–10 and from clinical trials11–23 indicate that complications from the onset of hyperglycemia progress unimpeded via the phenomenon of “metabolic memory” (MM) even when glycemic control is pharmaceutically achieved.11–23 This applies to both type 1 and type 2 diabetes. The underlying molecular mechanisms of hyperglycemic complications and metabolic memory involve: 1) the involvement of excess reactive oxygen species (ROS), 2) the involvement of advanced glycation end products (AGE), and 3) alterations in tissue-wide gene expression patterns.2,3 The heritable nature of metabolic memory24,25 points to involvement of the epigenome. In general terms, the epigenome is comprised of all chromatin modifying processes including DNA methylation and histone modifications allowing cells/organisms to quickly respond to changing environmental stimuli.26–28 Furthermore, these processes allow for quick adaptation to environmental stimuli but also impart the ability of the cell to “memorize” these encounters.24,25 The underlying molecular mechanism/s of MM has been examined via both animal model approaches and in vitro based studies.4–10 These studies have established that the initial hyperglycemia results in permanent aberrant gene expression in DM target tissues such as the: kidney, retina, cardiovascular system, skin as related to wound healing, and impaired blood vessel growth such as seen in wound healing.
糖尿病(DM)被归类为一种与全身葡萄糖水平稳态相关的代谢功能障碍疾病(如葡萄糖水平升高或所谓的高血糖症(HG)),到2030年,全球将有超过4亿人受到糖尿病(DM)的影响。2,3型糖尿病可细分为1型糖尿病和2型糖尿病。1型糖尿病的胰岛素生成能力受损,而2型糖尿病的机体对胰岛素的反应能力受损。虽然控制全身血糖水平对患者的健康至关重要,但糖尿病的长期继发性并发症也是一个同样重要的问题。在这方面,来自实验室的数据(4 - 10)和来自临床试验的数据(11 - 23)表明,即使在药物控制血糖的情况下,由高血糖开始的并发症也会通过“代谢记忆”(MM)现象不受阻碍地发展。这适用于1型和2型糖尿病。高血糖并发症和代谢记忆的潜在分子机制包括:1)过量活性氧(ROS)的参与,2)晚期糖基化终产物(AGE)的参与,以及3)组织范围内基因表达模式的改变。2,3代谢记忆的可遗传性24,25指向表观基因组的参与。一般来说,表观基因组由所有染色质修饰过程组成,包括DNA甲基化和组蛋白修饰,使细胞/生物体能够快速响应不断变化的环境刺激。此外,这些过程允许快速适应环境刺激,但也赋予细胞“记忆”这些遭遇的能力。24,25 MM的潜在分子机制已经通过动物模型方法和体外研究进行了检验。4-10这些研究已经证实,最初的高血糖会导致糖尿病靶组织(如肾脏、视网膜、心血管系统、皮肤)的永久性基因异常表达,这些组织与伤口愈合有关,并且在伤口愈合中可以看到血管生长受损。
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引用次数: 3
New insight of medical and molecular farming (MMF): the plants derived drugs 医学与分子农业(MMF)的新见解:植物衍生药物
Pub Date : 2018-10-05 DOI: 10.15406/MOJAP.2018.05.00216
A. Lombardi, R. Maggi
In the last years, research has revolutionized the use of valuable proteins for a variety of treatments and their production became possible since several genes can be efficiently expressed in many different biological systems.1 The expression systems so far available offer different advantages for the preparation of the recombinant proteins, in general, the optimal technical approach should guarantee the safety, the biological activity and the economic production. Molecular Farming, is a term indicating the technology for the production of high-value compounds in transgenic animals, and it is nowadays used to refer to the production of pharmaceutically important and commercially valuable proteins in plants.2
在过去的几年里,研究已经彻底改变了有价值的蛋白质在各种治疗中的使用,并且由于几种基因可以在许多不同的生物系统中有效表达,它们的生产成为可能目前已有的表达体系在制备重组蛋白方面各有优势,总的来说,最佳的技术途径应保证其安全性、生物活性和经济生产。分子农业是指在转基因动物中生产高价值化合物的技术,现在用来指在植物中生产具有重要药用价值和商业价值的蛋白质
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引用次数: 0
Protective effect of combined aqueous extracts of Allium sativum and Zingiber officinale against lead acetate induced hepatotoxicity and testicular damage in Rattus norvegicus 葱姜水提物对醋酸铅致褐家鼠肝毒性和睾丸损伤的保护作用
Pub Date : 2018-10-02 DOI: 10.15406/MOJAP.2018.05.00215
Y. Oboma, Beredugo Sylvanus, P. N. Okara, Favour A Tamuno-omie, Okama Eko Ibiang
Lead has been described as one of the most toxic metals in our environment.1 It also forms part of a group of metals described as carcinogenic in humans Its carcinogenic potential is considered to be dependent on the metal’s oxidation state, solubility and complex formation.2 Due to increasing anthropogenic activities and vehicular emissions, it has been indicated that the amount of lead available in the environment for potential consumption via food chains and drinking water supplies is on the rise.2 Lead poisoning is also a global health problem but it is unrecognized as such in a number of African countries. Lead poisoning as indicated by elevated blood lead levels (BLL) have been observed in the general population in some parts of Nigeria.3 In adults, occupational exposure to lead is the most common cause of lead poisoning with a wide range of physiological, biochemical, behavioural and organ dysfunctions mostly the kidney, liver, spleen and testes.3 In 2013, lead was believed to have resulted in 853,000 deaths, which occurred mostly in the developing countries with the poor been at greater risk.4 Descriptions of lead poisoning is dated to at least 2000 BC.5,6
铅被认为是环境中毒性最大的金属之一它也是一组被描述为对人类致癌的金属的一部分。它的致癌潜力被认为取决于金属的氧化状态、溶解度和络合物的形成由于人为活动和车辆排放的增加,环境中可通过食物链和饮用水供应供潜在消费的铅的数量正在增加铅中毒也是一个全球性的健康问题,但在一些非洲国家却没有认识到这一点。在尼日利亚的一些地区,已在普通人群中观察到血铅水平升高(BLL)所表明的铅中毒。3在成年人中,职业性接触铅是铅中毒的最常见原因,可引起广泛的生理、生化、行为和器官功能障碍,主要是肾、肝、脾和睾丸2013年,据信铅导致85.3万人死亡,这些死亡大多发生在发展中国家,穷人面临的风险更大关于铅中毒的描述至少可以追溯到公元前2000年
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引用次数: 4
期刊
MOJ Anatomy & Physiology
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