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A descriptive study of domestic and family violence presentations to an emergency department in the Northern Territory 对北部地区急诊科接诊的家庭暴力患者进行描述性研究。
IF 1.7 4区 医学 Q2 EMERGENCY MEDICINE Pub Date : 2024-04-21 DOI: 10.1111/1742-6723.14418
Lucy Owen MBBS, FACEM, Sibella Hare Breidahl MBBS, BMedSci (Hons), Maud Mussared MBBS, Sandra Brownlea BSc, MBBS, FACEM, David Kault MBBS, BSc, PhD

Objective

Examine the nature of domestic and family violence (DFV) presentations to an ED in the Northern Territory and identify potential gaps in service delivery.

Methods

Prospective descriptive study of DFV presentations in November 2021.

Results

A total of 70 presentations were identified, representing 1.2% of all presentations aged 16 years and older. Disproportionately impacted were First Nations people (90%), women (77.1%) and those aged less than 40 years (67.1%). Most (81.4%) arrived outside of business hours and only 37.1% were assessed by the social worker. Case complexity was increased by high rates of homelessness (30%), concurrent alcohol consumption (44.3%) and pregnancy (11.1% of females). More than a third (37.1%) had attended on one to four occasions in the previous 6 months with a DFV-related injury. Compared to non-DFV attendances, the median ED length of stay was approximately twice as long (456 vs 210 min), admissions rates to the ED short stay unit five times higher (25.7% vs 5.7%; P < 0.01, odds ratio [OR] = 5.7 and 95% confidence interval [CI] = 3.3–9.8) and rates of self-discharge prior to completion of care 9 times higher (12.9% vs 1.5%; P < 0.01, OR = 9.5 and 95% CI = 4.6–19.7).

Conclusion

The data highlights the need for a 24 h trauma-informed, culturally safe and integrated service to support people experiencing DFV. This could be achieved by a specialist unit designed and staffed by First Nations health practitioners.

目的:研究北部省一家急诊室接诊的家庭暴力(DFV)患者的性质,并找出提供服务方面的潜在差距。方法:对 2021 年 11 月接诊的 DFV 患者进行回顾性描述研究。原住民(90%)、女性(77.1%)和 40 岁以下人群(67.1%)受到的影响尤为严重。大多数人(81.4%)是在工作时间以外到达的,只有 37.1%的人得到了社工的评估。无家可归(30%)、同时饮酒(44.3%)和怀孕(11.1% 的女性)的比例较高,增加了案件的复杂性。超过三分之一的受访者(37.1%)在过去 6 个月内曾有一至四次与家庭暴力相关的受伤经历。与非 DFV 就诊者相比,急诊室的中位住院时间约为前者的两倍(456 分钟对 210 分钟),急诊室短期住院部的入院率是前者的五倍(25.7% 对 5.7%;P < 0.01,几率比 [OR] = 5.7,95% 置信区间 [CI] = 3.3-9.8),而自行出院率是前者的五倍。结论:这些数据突出表明,有必要提供 24 小时创伤知情、文化安全的综合服务,为遭受家庭暴力的人提供支持。这可以通过由原住民医疗从业人员设计并配备人员的专业机构来实现。
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引用次数: 0
The Buddy Study: Local reach, adoption and implementation following a randomised controlled trial of conservative management of fifth metacarpal neck fractures 巴迪研究:第五掌骨颈骨折保守治疗随机对照试验在当地的影响、采用和实施情况
IF 1.7 4区 医学 Q2 EMERGENCY MEDICINE Pub Date : 2024-04-16 DOI: 10.1111/1742-6723.14412
Charlotte Mary Alexander MBBS, Eve Purdy MD, MBA, FRCPC, FACEM, Aoife Reynolds RN, Luc Nguyen M.Sc (Physio), MD, Richard AF Pellatt MBChB, BA[Hons], FACEM, Gerben Keijzers MBBS, MSc, FACEM, PhD

Objective

To understand the reach, adoption and implementation of the evidence that buddy strapping for uncomplicated fifth metacarpal neck fractures is non-inferior to plaster casting.

Methods

Mixed-method study using clinical audit of the years before and after the original randomised controlled study was published (2019) and staff questionnaires/semi-structured interviews.

Results

Sixty-nine percent of questionnaire respondents were aware of the original study findings (i.e. reach) and 57% had adopted the research findings. The proportion of patients receiving buddy strapping was 6% in 2014–2016 and 28% in 2019–2021 (implementation). Qualitative data provided insight into ongoing barriers to adoption and implementation including fear of reprisal, the need for permission, opinions of senior decision makers, perceptions about patient preferences, and an overall tendency to ‘play it safe’.

Conclusions

Even in a department where primary research is conducted, implementation requires ongoing attention to factors impacting reach and adoption.

方法采用原始随机对照研究发表前后几年(2019年)的临床审计和员工问卷调查/半结构式访谈进行混合方法研究。结果69%的问卷调查对象了解原始研究结果(即了解),57%的问卷调查对象采用了研究结果。2014-2016年接受好友绑扎的患者比例为6%,2019-2021年为28%(实施情况)。定性数据深入揭示了采用和实施的持续障碍,包括害怕报复、需要获得许可、高级决策者的意见、对患者偏好的看法以及 "稳妥行事 "的总体倾向。
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引用次数: 0
Review article: Patients who leave before care is completed: What does the legal duty to warn mean for emergency department clinicians? 评论文章:未完成护理就离开的患者:警告的法律义务对急诊科临床医生意味着什么?
IF 2.3 4区 医学 Q2 Medicine Pub Date : 2024-04-16 DOI: 10.1111/1742-6723.14407
Michael Eburn PhD, LLM, LLB, Tina Cockburn BCom, LLB(Hons), LLM, Anne-Maree Kelly MD, FACEM, MHealth&MedLaw

Patients leave ED for a variety of reasons and at all stages of care. In Australian law, clinicians and health services owe a duty of care to people presenting to the ED for care, even if they have not yet entered a treatment space. There is also a positive duty to warn patients of material risks associated with their condition, proposed treatment(s), reasonable alternative treatment options and the likely effect of their healthcare decisions, including refusing treatment. This extends to a decision to leave the ED before care is completed. The form of that warning may vary based on what is known about the patient's condition and the associated risks at the time. Specific documentation of warnings given is essential.

患者离开急诊室的原因多种多样,而且处于各个护理阶段。在澳大利亚法律中,临床医生和医疗服务机构有责任为到急诊室就诊的患者提供护理,即使他们尚未进入治疗空间。此外,临床医生和医疗服务机构还有义务向患者警告与其病情、建议治疗、合理替代治疗方案以及其医疗决定(包括拒绝治疗)可能产生的影响有关的重大风险。这也包括在治疗结束前离开急诊室的决定。警告的形式可以根据当时对患者病情和相关风险的了解而有所不同。必须将发出警告的具体情况记录在案。
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引用次数: 0
Short waits, happy patients and expert care, moving basic musculoskeletal care from the emergency department to a physiotherapist-led diversion pathway 等待时间短、患者满意、专家护理,将基本的肌肉骨骼护理从急诊科转移到物理治疗师主导的分流路径上
IF 1.7 4区 医学 Q2 EMERGENCY MEDICINE Pub Date : 2024-04-15 DOI: 10.1111/1742-6723.14416
Piers Truter M.Clin PHTY, Pippa Flanagan M. Clin PHTY, Robert Waller PhD, Karen Richards D. Clin PHTY, Marshall Makate PhD, Anthony Johnstone B. PHTY (Hons), Luke Bongiascia MBA, Katrina Spilsbury PhD, Vinicius Cavalheri PhD, Ivan Lin PhD

Objective

Patients with musculoskeletal conditions (MSKCs) are highly prevalent in ED. This project explores the impact of the pilot phase of a ‘diversion pathway’, which directed patients with MSKCs from the ED waiting room to an outpatient clinic led by advanced-scope physiotherapists.

Methods

A prospective intervention study comparing care outcomes between patients in the ‘diversion pathway’ with usual ED care. The characteristics of patients considered eligible and non-eligible are described.

Results

Between May and December 2022, 1099 patients were diverted. For diverted patients, mean length of stay (LOS) in ED was reduced by 110 (95% confidence interval [CI]: 99–120) min and 4 h rule compliance improved by 19.3% compared to usual ED care. There were fewer patients who ‘did not wait’ (DNW) with the diversion pathway. The diverted group was young (median age 22 years and 41% paediatric), mostly low urgency, self-referred and arrived by private transport with minor limb trauma. The diversion pathway triage process appropriately identified 182 patients ineligible for diversion. 96.7% of patients reported satisfaction with care received from the diversion pathway. There was no change in ED representation rates for diverted patients.

Conclusions

A new pathway resulted in reduced LOS, reduced DNW, high patient satisfaction and more people being discharged within 4 h for diverted patients compared to usual ED care. The pathway increased ED capacity, improved key ED performance metrics and safely expedited care delivery for patients.

目的肌肉骨骼疾病(MSKC)患者在急诊室的发病率很高。该项目探讨了 "分流路径 "试验阶段的影响,该路径将肌肉骨骼疾病患者从急诊室候诊室引导至由高级物理治疗师领导的门诊诊所。方法一项前瞻性干预研究,比较了 "分流路径 "患者与常规急诊室护理之间的护理效果。结果在2022年5月至12月期间,共有1099名患者接受了分流治疗。与常规急诊室护理相比,分流患者在急诊室的平均住院时间(LOS)缩短了 110 分钟(95% 置信区间 [CI]:99-120),4 小时规则符合率提高了 19.3%。采用分流路径后,"未等待"(DNW)的患者人数减少。分流患者年龄较小(中位年龄为 22 岁,41% 为儿科患者),大多病情较轻,自行转诊,并由私人交通工具送来,肢体有轻微外伤。分流路径的分流过程恰当地识别出了 182 名不符合分流条件的患者。96.7% 的患者对分流路径提供的护理表示满意。结论与常规急诊室护理相比,新路径缩短了分流病人的生命周期,减少了 DNW,病人满意度高,更多病人在 4 小时内出院。该路径提高了急诊室的容量,改善了急诊室的主要绩效指标,并安全地加快了对患者的护理。
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引用次数: 0
The shock index predicts in-flight blood transfusion in aeromedical trauma patients 休克指数可预测航空创伤患者的飞行输血量
IF 1.7 4区 医学 Q2 EMERGENCY MEDICINE Pub Date : 2024-04-11 DOI: 10.1111/1742-6723.14413
Benjamin Powell BSc, PGDipHSM, MBBS, GCertTM, MPH, DipPHRM, FACEM, Susanna Cramb PhD

Objective

To define the utility of the Triage Revised Trauma Score (TRTS), GCS/Age/arterial Pressure (GAP) score, and shock index (SI) in predicting the need for in-flight blood product administration in civilian trauma patients transported by an aeromedical platform.

Methods

A retrospective chart review of 3582 aeromedical trauma cases was conducted. An initial TRTS, GAP score and SI were calculated for each patient, and the administration of in-flight blood products was also recorded. Receiver operating characteristic (ROC) curves were used to quantify the predictive discrimination of the TRTS, GAP score and SI on the need for in-flight blood product administration.

Results

The SI showed a superior predictive value compared to the TRTS and GAP score. The SI showed an area under the curve on the ROC curve of 0.85 in both primary and inter-hospital transfer cases, indicating reasonable predictive value.

Conclusion

The SI demonstrates favourable test characteristics for predicting the need for in-flight blood product administration. Prospective validation of these results is warranted.

目的 界定创伤分诊修订评分(TRTS)、GCS/年龄/动脉压(GAP)评分和休克指数(SI)在预测由空中医疗平台运送的民用创伤患者是否需要在机上使用血液制品方面的作用。方法 对 3582 例空中医疗创伤病例进行了回顾性病历审查。计算了每位患者的初始 TRTS、GAP 评分和 SI,并记录了机上血液制品的使用情况。结果与 TRTS 和 GAP 评分相比,SI 显示出更高的预测价值。在初诊和医院间转院病例中,SI 的 ROC 曲线下面积均为 0.85,显示出合理的预测价值。有必要对这些结果进行前瞻性验证。
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引用次数: 0
Adaptive platform trials rather than randomised controlled trials for paediatric sepsis 针对儿科败血症的适应性平台试验而非随机对照试验
IF 2.3 4区 医学 Q2 Medicine Pub Date : 2024-04-10 DOI: 10.1111/1742-6723.14409
Elliot Long BSc, BMBS, FRACP, PhD, Andrew Davidson MBBS, MD, FANZCA, FAHMS, Katherine J Lee BSc, MSc, PhD, Franz E Babl MD, MPH, DMedSc, FRACP, FAAP, FACEP, Shane George BSc, MBBS, MPH, FACEM, FCICM

Adaptive platform trials (APTs) offer a promising alternative to traditional randomised controlled trials for evaluating treatments for paediatric sepsis. Randomised controlled trials, despite being the gold standard for establishing causality between interventions and outcomes, make many assumptions about disease prevalence, severity and intervention effects, which are often incorrect. As a result, the evidence for most treatments for paediatric sepsis are based on low-quality evidence. APTs use accrued data rather than assumptions to power trial adaptations. They can assess multiple treatments simultaneously with shared research infrastructure. As such, APTs offer a more efficient, flexible and more effective way to identify optimal treatments. The proposed Paediatric Adaptive Sepsis Platform Trial, leveraging the Paediatric Research in Emergency Departments International Collaborative network's infrastructure, will evaluate resuscitation fluids, vasoactive medications, corticosteroids and antimicrobials. This trial has the potential to substantially impact clinical practice and reduce global sepsis mortality in children.

自适应平台试验(APT)为评估儿科败血症的治疗方法提供了一种替代传统随机对照试验的可行方法。尽管随机对照试验是确定干预措施与结果之间因果关系的黄金标准,但它对疾病的患病率、严重程度和干预效果做出了许多假设,而这些假设往往是不正确的。因此,大多数治疗小儿败血症的证据都是基于低质量的证据。APT 使用累积的数据而不是假设来进行试验调整。它们可以利用共享的研究基础设施同时评估多种治疗方法。因此,APT 为确定最佳治疗方法提供了一种更高效、更灵活、更有效的方法。拟议中的儿科适应性败血症平台试验将利用儿科急诊研究国际合作网络的基础设施,对复苏液、血管活性药物、皮质类固醇和抗菌药物进行评估。这项试验有可能对临床实践产生重大影响,并降低全球儿童败血症死亡率。
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引用次数: 0
Trends in reported GHB-related presentations to Sydney emergency departments between 2012 and 2021 2012 年至 2021 年悉尼急诊科报告的 GHB 相关就诊人数趋势。
IF 1.7 4区 医学 Q2 EMERGENCY MEDICINE Pub Date : 2024-04-01 DOI: 10.1111/1742-6723.14402
Oliver Harris, Krista J Siefried RN, BScN, GradDipCardio, PhD, Angela Chiew BMedSci, MBBS(Hons), PhD, Nazila Jamshidi B.Pharm (Hons), PhD, MBBS, FRACP, FAChAM, Daniel T Chung, Nicholas Moore MBBS, MPH, FACEM, Una Nic Ionmhain MB BCh, BAO FACEM, MSc (clin tox cardiff), Darren M Roberts PhD, FRACP, FAChAM, Nadine Ezard MBBS, BA, MPH, PhD, FAChAM, Jonathan Brett MBBS (Hons), BMedSci (Hons), FAChAM, FRACP, GradDipTox, PhD

Objectives

In overdose, gamma-hydroxybutyrate (GHB) and its precursors can cause decreased levels of consciousness, coma and death. Here, we aim to describe reported exposure to GHB at four EDs in Sydney, New South Wales (NSW), Australia.

Methods

We searched the ED databases of four Sydney metropolitan hospitals for presentations relating to GHB exposure between 2012 and 2021. We calculated annual number of presentations stratified by hospital, age, sex, mode of arrival and triage category.

Results

A total of 3510 GHB-related presentations to ED were recorded across the four hospitals. Data for all hospitals were only available from 2015 onwards and between 2015 and 2021; there was a 114% increase in annual presentations (from 228 to 487). Males represented 68.7% of all presentations and the median age was 31 years (range 16–74 years). There was an increase in the proportion of female presentations between 2012 and 2021 (from 27.9% to 37.9%) along with the severity of presentation over the same period, with the proportion of presentations with a triage category 1 increasing from 19.7% to 34.5%.

Conclusions

Increases in recorded absolute number and severity of GHB-related presentations to Sydney EDs are a major public health concern. There may also be shifts in the demographics of those with GHB-related presentations. Renewed efforts are required to understand the drivers of these increases to optimally target harm reduction approaches.

目的:过量使用γ-羟丁酸(GHB)及其前体可导致意识减退、昏迷和死亡。在此,我们旨在描述澳大利亚新南威尔士州悉尼市四家急诊室报告的 GHB 暴露情况:我们在悉尼四家都市医院的急诊室数据库中搜索了 2012 年至 2021 年期间与伽马--羟丁酸接触相关的病例。我们按医院、年龄、性别、到达方式和分诊类别计算了每年的就诊人数:四家医院共记录了 3510 例与 GHB 相关的急诊病例。所有医院的数据只能从 2015 年开始提供,而在 2015 年至 2021 年期间,每年的就诊人数增加了 114%(从 228 人增至 487 人)。男性占所有就诊者的 68.7%,年龄中位数为 31 岁(16-74 岁不等)。2012 年至 2021 年期间,女性患者的比例有所上升(从 27.9% 上升至 37.9%),同期患者的严重程度也有所上升,分流类别为 1 的患者比例从 19.7% 上升至 34.5%:结论:悉尼急诊室记录的与伽马--羟丁酸(GHB)相关的就诊绝对人数和严重程度的增加是一个重大的公共卫生问题。与 GHB 相关的就诊者的人口结构也可能发生变化。我们需要继续努力了解这些增长的驱动因素,以便有针对性地采取减少危害的措施。
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引用次数: 0
Refining ambulance clinical response models: The impact on ambulance response and emergency department presentations 完善救护车临床响应模型:对救护车响应和急诊科就诊的影响。
IF 1.7 4区 医学 Q2 EMERGENCY MEDICINE Pub Date : 2024-04-01 DOI: 10.1111/1742-6723.14406
Emily Nehme MBiostats, Karen Smith PhD, Colin Jones GDipHlthSci(MICA), Shelley Cox PhD, Peter Cameron MBBS MD, Ziad Nehme PhD

Objective

The ambulance service in Victoria, Australia implemented a revised clinical response model (CRM) in 2016 which was designed to increase the diversion of low-acuity Triple Zero (000) calls to secondary telephone triage and reduce emergency ambulance dispatches. The present study evaluates the influence of the revised CRM on emergency ambulance response times and ED presentations.

Methods

A retrospective study of emergency calls for ambulance between 1 January 2015 and 31 December 2018. Ambulance data were linked with ED presentations occurring up to 48 h after contact. Interrupted time series analyses were used to evaluate the impact of the revised CRM.

Results

A total of 2 365 529 calls were included. The proportion allocated a Code 1 (time-critical, lights/sirens) dispatch decreased from 56.6 to 41.0% after implementation of the revised CRM. The proportion of calls not receiving an emergency ambulance increased from 10.4 to 19.6%. Interrupted time series analyses demonstrated an improvement in Code 1 cases attended within 15 min (Key Performance Indicator). However, for patients with out-of-hospital cardiac arrest or requiring lights and sirens transport to hospital, there was no improvement in response time performance. By the end of the study period, there was also no difference in the proportion of callers presenting to ED when compared with the estimated proportion assuming the revised CRM had not been implemented.

Conclusion

The revised CRM was associated with improved Code 1 response time performance. However, there was no improvement in response times for high acuity patients, and no change in the proportion of callers presenting to ED.

目的:澳大利亚维多利亚州的救护车服务于2016年实施了修订后的临床响应模式(CRM),该模式旨在将低危急值的 "三零"(000)呼叫转移到二级电话分流,并减少急救车派遣。本研究评估了修订后的CRM对急救车响应时间和急诊室就诊情况的影响:对 2015 年 1 月 1 日至 2018 年 12 月 31 日期间的救护车紧急呼叫进行回顾性研究。救护车数据与接触后 48 小时内出现的急诊室病例相关联。采用间断时间序列分析来评估修订后的 CRM 的影响:结果:共纳入 2 365 529 次呼叫。实施修订后的 CRM 后,分配到代码 1(时间紧迫、灯光/警报器)调度的比例从 56.6% 降至 41.0%。未获得紧急救护车的呼叫比例从 10.4% 增加到 19.6%。中断时间序列分析表明,在 15 分钟内到达现场的代码 1 病例(关键绩效指标)有所改善。然而,对于院外心脏骤停或需要警灯和警报器送往医院的病人,响应时间的表现没有改善。在研究期结束时,与假定未实施修订后的 CRM 时的估计比例相比,急诊室接听电话者的比例也没有差异:结论:修订后的客户关系管理系统提高了代码 1 的响应速度。结论:修订后的客户关系管理系统改善了代码 1 的响应时间,但高危重病人的响应时间没有得到改善,急诊室接听电话的比例也没有变化。
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引用次数: 0
Evaluation of a pathway to address take own leave events for First Nations peoples presenting for emergency care: The Deadly RED project 对解决原住民急诊请假事件的途径进行评估:Deadly RED 项目。
IF 1.7 4区 医学 Q2 EMERGENCY MEDICINE Pub Date : 2024-03-31 DOI: 10.1111/1742-6723.14397
Michelle Davison MBBS FACEM, Jason Chan MBBS, FACEM, Meg Clarke BNurs, Caroline Mitchell RN, MNP, Alan Yan BM, FACEM, MHA, Emma Ballard BAppSc(Hons), M Biostatistics (PHD), Elwyn Henaway

Objective

The ‘Deadly RED’ project primarily aimed to improve culturally competent care to reduce the number of First Nations patients presenting to a Queensland ED who ‘Take own leave’ (TOL). The secondary aim was to evaluate the implementation project.

Methods

A pre/post-test quasi experimental study design using mixed methods was co-designed with adherence to Indigenous research considerations. Quantitative analysis of First Nations presentations before and after Deadly RED implementation was performed using SPSS. Qualitative analysis of transcribed research yarns in NVIVO was coded and themed for analysis. Staff experiences and perspectives were collated using electronically distributed surveys and process audits were performed.

Results

A total of 1096 First Nations presentations June to August 2021 and 1167 in the matched 2022 post-implementation period were analysed. Significantly more patients were recorded as TOL post-implementation (13.0% pre vs 21.3% post) and representations rates were unchanged. Forty-six staff surveyed identified improvements in all parameters including cultural appropriateness and quality of care. Qualitative analysis of 85 research yarns revealed themes migrated to increasingly acceptable, accessible, and usable care. Notably, 45% of the First Nation's patients recorded as TOL self-reported that their treatment was complete. The study was feasible as 80% of packs distributed and 73% follow-up screening after TOL.

Conclusions

The Deadly RED evaluation revealed significant discrepancies in the reported data points of TOL and the ‘story’ of the First Nations persons experience of appropriate and completed care. Staff awareness and cultural capability improved significantly, and yarning allowed knowledge translation and improvements in communication which contributed to a better healthcare experience for First Nations patients attending our ED.

目标:Deadly RED "项目的主要目的是改善文化适宜性护理,以减少昆士兰州急诊室的原住民患者 "自行离院"(TOL)的人数。次要目的是评估项目的实施情况:方法:采用混合方法共同设计了一项前/后测试准实验研究设计,并考虑到了土著研究因素。使用 SPSS 对 "致命 RED "实施前后原住民的发言进行了定量分析。对 NVIVO 中转录的研究报告进行了定性分析,并进行了编码和主题分析。使用电子分发的调查问卷整理了员工的经验和观点,并进行了流程审计:对 2021 年 6 月至 8 月的 1096 例原住民病例和 2022 年实施后的 1167 例原住民病例进行了分析。实施后被记录为TOL的患者明显增多(实施前为13.0%,实施后为21.3%),陈述率保持不变。接受调查的 46 名员工认为所有参数都有所改善,包括文化适宜性和护理质量。对 85 项研究成果进行的定性分析显示,研究主题已转移到可接受性、可访问性和可用性越来越高的护理方面。值得注意的是,原住民中 45% 被记录为 TOL 的患者自我报告说他们的治疗已经完成。这项研究是可行的,因为在 TOL 之后,80% 发放的药包和 73% 的后续筛查都是可行的:Deadly RED 评估显示,报告的 TOL 数据点与原住民获得适当和完整护理的 "故事 "存在重大差异。工作人员的意识和文化能力都有了显著提高,通过学习实现了知识转化并改善了沟通,从而为到我们急诊室就诊的原住民患者带来了更好的医疗体验。
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引用次数: 0
Has the rescheduling of modified-release paracetamol in Australia affected the frequency of overdoses? 澳大利亚重新安排改良释放型扑热息痛的使用是否影响了过量使用扑热息痛的频率?
IF 1.7 4区 医学 Q2 EMERGENCY MEDICINE Pub Date : 2024-03-26 DOI: 10.1111/1742-6723.14403
Michaela J Ryan MD, BMedSc (Hons), Andis Graudins MBBS, PHD, Nicole O'Shea Bachelor of pharmacy, Firouzeh Noghrehchi PHD, Anselm Wong MBBS, PHD

Objectives

In June 2020, modified-release paracetamol (paracetamol-MR) preparations were up-scheduled from schedule-2 (available in pharmacy) to schedule-3 (available by request to a pharmacist only). The present study aims to ascertain whether up-scheduling affected the frequency of paracetamol-MR overdoses.

Methods

This is a retrospective cohort study of two data sets from 1 June 2017 to 31 May 2022. Monash Health data were extracted using the diagnosis of paracetamol overdose coding and electronic medical records data. Calls regarding paracetamol-MR overdoses to Victorian Poisons Information Centre (VPIC) were extracted from the Poisons centre call database. We used a quasi-experimental research design with interrupted time series analysis to evaluate the immediate impact and change in trend of poisoning-related calls and ED presentations before and after June 2020. The change in proportion of paracetamol-MR cases in both databases was analysed using the Χ2 test.

Results

The proportion of paracetamol-MR cases in both data sets did not change. From Monash Health, there was no level change in monthly paracetamol-MR overdose-related presentations following re-scheduling (rate ratio [RR] = 1.08, 95% confidence interval [CI] = 0.57–2.01). There was no change in monthly paracetamol-MR overdose-related calls to VPIC following re-scheduling (RR = 1.05, 95% CI = 0.96–1.14).

Conclusion

The proportion of paracetamol-MR overdoses did not decrease after the up-scheduling to S3. Similarly, the frequency of overdoses by month remained similar. Further limitations on access to paracetamol products may need to be considered.

目标:2020年6月,改良缓释扑热息痛(扑热息痛-MR)制剂从附表2(药房有售)上调至附表3(只需向药剂师申请即可获得)。本研究旨在确定上调附表是否会影响过量服用扑热息痛-MR 的频率:这是一项回顾性队列研究,涉及2017年6月1日至2022年5月31日的两组数据。利用扑热息痛过量的诊断编码和电子病历数据提取了莫纳什卫生局的数据。从毒物中心呼叫数据库中提取了维多利亚州毒物信息中心(VPIC)接到的有关扑热息痛-MR过量的呼叫。我们采用间断时间序列分析的准实验研究设计来评估 2020 年 6 月前后中毒相关电话和急诊室就诊人数的直接影响和趋势变化。使用Χ2检验分析了两个数据库中扑热息痛-MR病例比例的变化:结果:两个数据集中的扑热息痛-MR病例比例均未发生变化。从莫纳什卫生院的数据来看,重新安排后,每月与扑热息痛-MR 药物过量相关的病例数没有发生变化(比率比 [RR] = 1.08,95% 置信区间 [CI] = 0.57-2.01)。重新安排后,每月向 VPIC 拨打的与扑热息痛-MR 药物过量相关的电话数量没有变化(RR = 1.05,95% CI = 0.96-1.14):结论:将扑热息痛-MR 药物过量的比例提高到 S3 级后并没有降低。同样,各月过量使用扑热息痛的频率也保持相似。可能需要考虑进一步限制获取扑热息痛产品的途径。
{"title":"Has the rescheduling of modified-release paracetamol in Australia affected the frequency of overdoses?","authors":"Michaela J Ryan MD, BMedSc (Hons),&nbsp;Andis Graudins MBBS, PHD,&nbsp;Nicole O'Shea Bachelor of pharmacy,&nbsp;Firouzeh Noghrehchi PHD,&nbsp;Anselm Wong MBBS, PHD","doi":"10.1111/1742-6723.14403","DOIUrl":"10.1111/1742-6723.14403","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>In June 2020, modified-release paracetamol (paracetamol-MR) preparations were up-scheduled from schedule-2 (available in pharmacy) to schedule-3 (available by request to a pharmacist only). The present study aims to ascertain whether up-scheduling affected the frequency of paracetamol-MR overdoses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This is a retrospective cohort study of two data sets from 1 June 2017 to 31 May 2022. Monash Health data were extracted using the diagnosis of paracetamol overdose coding and electronic medical records data. Calls regarding paracetamol-MR overdoses to Victorian Poisons Information Centre (VPIC) were extracted from the Poisons centre call database. We used a quasi-experimental research design with interrupted time series analysis to evaluate the immediate impact and change in trend of poisoning-related calls and ED presentations before and after June 2020. The change in proportion of paracetamol-MR cases in both databases was analysed using the <i>Χ</i><sup>2</sup> test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The proportion of paracetamol-MR cases in both data sets did not change. From Monash Health, there was no level change in monthly paracetamol-MR overdose-related presentations following re-scheduling (rate ratio [RR] = 1.08, 95% confidence interval [CI] = 0.57–2.01). There was no change in monthly paracetamol-MR overdose-related calls to VPIC following re-scheduling (RR = 1.05, 95% CI = 0.96–1.14).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The proportion of paracetamol-MR overdoses did not decrease after the up-scheduling to S3. Similarly, the frequency of overdoses by month remained similar. Further limitations on access to paracetamol products may need to be considered.</p>\u0000 </section>\u0000 </div>","PeriodicalId":11604,"journal":{"name":"Emergency Medicine Australasia","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1742-6723.14403","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Emergency Medicine Australasia
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