Electronics最新文献

"Hiding in Plain Sight" (HIPS) strategies for Personal Health Information (PHI) replace PHI with surrogate values to hinder re-identification attempts. We evaluate three different HIPS strategies for PHI replacement, a standard Consistent replacement strategy, a Random replacement strategy, and a novel Markov model strategy. We evaluate the privacy-preserving benefits and relative utility for information extraction of these strategies on both a simulated PHI distribution and real clinical corpora from two different institutions using a range of false negative error rates (FNER). The Markov strategy consistently outperformed the Consistent and Random substitution strategies on both real data and in statistical simulations. Using FNER ranging from 0.1% to 5%, PHI leakage at the document level could be reduced from 27.1% to 0.1% and from 94.2% to 57.7% with the Markov strategy versus the standard Consistent substitution strategy, at 0.1% and 0.5% FNER, respectively. Additionally, we assessed the generated corpora containing synthetic PHI for reuse using a variety of information extraction methods. Results indicate that modern deep learning methods have similar performance on all strategies, but older machine learning techniques can suffer from the change in context. Overall, a Markov surrogate generation strategy substantially reduces the chance of inadvertent PHI release.

Cardiovascular disease is a leading cause of death worldwide. The differentiation of human pluripotent stem cells (hPSCs) into functional cardiomyocytes offers significant potential for disease modeling and cell-based cardiac therapies. However, hPSC-derived cardiomyocytes (hPSC-CMs) remain largely immature, limiting their experimental and clinical applications. A critical challenge in current in vitro culture systems is the absence of standardized metrics to quantify maturity. This study presents a data-driven pipeline to quantify hPSC-CM maturity using gene expression data across various stages of cardiac development. We determined that culture time serves as a feasible proxy for maturity. To improve prediction accuracy, machine learning algorithms were employed to identify heart-related genes whose expression strongly correlates with culture time. Our results reduced the average discrepancy between predicted and observed culture time to 4.461 days and CASQ2 (Calsequestrin 2), a gene involved in calcium ion storage and transport, was identified as the most critical cardiac gene associated with culture duration. This novel framework for maturity assessment moves beyond traditional qualitative methods, providing deeper insights into hPSC-CM maturation dynamics. It establishes a foundation for developing advanced lab-on-chip devices capable of real-time maturity monitoring and adaptive stimulus selection, paving the way for improved maturation strategies and broader experimental/clinical applications.

The accurate identification of medicine vials is crucial for emergency medical services, especially for vials that resemble one another but have different labels, volumes, and concentrations. This study introduces a method to detect vials in real-time using mixed reality technology through Microsoft HoloLens 2. The system is also equipped with an SQL server to manage barcode and vial information. We conducted a comparative analysis of the barcode detection capabilities of the HoloLens 2 camera and an external scanner. The HoloLens 2 effectively identified larger barcodes when they were 20-25 cm away in normal lighting conditions. However, it faced difficulties in detecting smaller barcodes that were consistently detected by the external scanner. The frame rate investigation revealed performance fluctuations: an average of 10.54 frames per second (fps) under standard lighting conditions, decreasing to 10.10 fps in low light and further reducing to 10.05 fps when faced with high barcode density. Resolution tests demonstrated that a screen resolution of 1920 × 1080 yielded the best level of accuracy, with a precision rate of 98%. On the other hand, a resolution of 1280 × 720 achieved a good balance between accuracy 93% and speed. The HoloLens 2 demonstrates satisfactory performance under ideal circumstances; however, enhancements in detecting algorithms and camera resolution are required to accommodate diverse surroundings. This approach seeks to help paramedics make quick and accurate decisions during critical situations and tackle common obstacles such as reliance on networks and human mistakes. Our new approach of a hybrid method that integrates an external Bluetooth scanner with the MR device gives optimal results compared to the scanner-only approach.

This paper outlines a design approach for biomedical wireless power transfer systems with a focus on three-coil inductive links for neonatal intensive care unit applications. The relevant literature has been explored to support the design approach, equations, simulation results, and the process of experimental analysis. The paper begins with a brief overview of various power amplifier classes, followed by an in-depth examination of the most common power amplifiers used in biomedical wireless power transfer systems. Among the traditional linear and switching amplifier classes, class-D and class-E switching amplifiers are highlighted for their enhanced efficiency and straightforward implementation in biomedical contexts. The impact of load variation on these systems is also discussed. This paper then explores the basic concepts and essential equations governing inductive links, comparing two-coil and multi-coil configurations. In the following, the paper discusses foundational coil parameters and provides theoretical and experimental analysis of both two-coil and multi-coil inductive links through step-by-step measurement techniques using lab equipment and addressing the relevant challenges. Finally, a case study for neonatal intensive care unit applications is presented, showcasing a wireless power transfer system operating at 13.56 MHz for powering a wearable device on a patient lying on a mattress. An inductive link with a transmitter coil embedded in a mattress is designed to supply power to a load at distances ranging from 4 cm to 12 cm, simulating the mattress-to-chest distance of an infant. the experimental results of a three-coil inductive link equipped with a Class-E power amplifier are reported, demonstrating power transfer efficiency ranging from 75% to 25% and power delivery to a 500 Ω-load varying from 340 mW to 25 mW over various distances.