Pub Date : 2025-02-28DOI: 10.1177/15357597251318564
Chengyuan Wu, Robyn M Busch, Daniel L Drane, Patricia Dugan, Demitre Serletis, Brett Youngerman, Lara Jehi
Resective surgery for drug-resistant temporal lobe epilepsy remains underutilized in the United States. While anteromesial temporal lobectomy consistently achieves the highest rates of long-term seizure freedom, it comes with greater risks for memory and language decline. Magnetic resonance imaging-guided laser interstitial thermal therapy and neuromodulation have gained popularity due to perceived lower surgical risk and faster recovery, although they yield lower rates of sustained seizure freedom. Neuromodulation with vagus nerve, deep brain, or responsive neurostimulation provides an option for patients ineligible for resection or ablation, but overall seizure outcomes remain modest. Balancing improved seizure control with open resection against the potential cognitive advantages of less invasive treatments is complex, requiring careful patient selection. Future research must refine these approaches to optimize results. Thoughtful, individualized decision-making, guided by each patient's clinical scenario and goals, is paramount for achieving the best balance between seizure freedom, cognitive preservation, and overall patient outcome.
{"title":"Comparative Review of Seizure and Cognitive Outcomes in Resective, Ablative, and Neuromodulatory Temporal Lobe Epilepsy Surgery.","authors":"Chengyuan Wu, Robyn M Busch, Daniel L Drane, Patricia Dugan, Demitre Serletis, Brett Youngerman, Lara Jehi","doi":"10.1177/15357597251318564","DOIUrl":"https://doi.org/10.1177/15357597251318564","url":null,"abstract":"<p><p>Resective surgery for drug-resistant temporal lobe epilepsy remains underutilized in the United States. While anteromesial temporal lobectomy consistently achieves the highest rates of long-term seizure freedom, it comes with greater risks for memory and language decline. Magnetic resonance imaging-guided laser interstitial thermal therapy and neuromodulation have gained popularity due to perceived lower surgical risk and faster recovery, although they yield lower rates of sustained seizure freedom. Neuromodulation with vagus nerve, deep brain, or responsive neurostimulation provides an option for patients ineligible for resection or ablation, but overall seizure outcomes remain modest. Balancing improved seizure control with open resection against the potential cognitive advantages of less invasive treatments is complex, requiring careful patient selection. Future research must refine these approaches to optimize results. Thoughtful, individualized decision-making, guided by each patient's clinical scenario and goals, is paramount for achieving the best balance between seizure freedom, cognitive preservation, and overall patient outcome.</p>","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597251318564"},"PeriodicalIF":5.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-28DOI: 10.1177/15357597251318573
Edward Glasscock
{"title":"From General Anesthetic to Designer Antiepileptic: Propofol's Mechanism of Action Reveals Hope for Precision Treatment of HCN1-Related Epilepsy.","authors":"Edward Glasscock","doi":"10.1177/15357597251318573","DOIUrl":"https://doi.org/10.1177/15357597251318573","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597251318573"},"PeriodicalIF":5.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-28DOI: 10.1177/15357597251318577
Elaine T Kiriakopoulos, Felicia Chu, Jay Salpekar, Gaston Baslet, Gena Ghearing, Hamada Altalib, Martha Sajatovic
The increased risk for psychosocial burden and suicidality in people with epilepsy compared to the general population is a well-established global public health concern. Suicidality risk is also increased in patients with functional seizures. The timely identification of patients at highest risk for psychosocial burden and self-harm is vital. This can pose a significant challenge for multidisciplinary clinicians caring for people with epilepsy. Early identification of social stressors and comorbid psychiatric contributors via screening are required to assist with the development of predictive models for self-harm in epilepsy; and subsequent options for treatment and the provision of adjunct supports in the community may help lead to evidence-based suicide prevention strategies for people with epilepsy. Too often, pervasive and common social stressors leading to self-harm go unrecognized and undertreated. Elevating clinician awareness of patient subpopulations at highest risk for suicide, and informing on the advent of evidence-based self-management programs targeting depression and self-harm presents an opportunity to increase suicide prevention in epilepsy.
{"title":"Psychosocial Burden and Suicidality in Epilepsy: A Public Health Concern.","authors":"Elaine T Kiriakopoulos, Felicia Chu, Jay Salpekar, Gaston Baslet, Gena Ghearing, Hamada Altalib, Martha Sajatovic","doi":"10.1177/15357597251318577","DOIUrl":"https://doi.org/10.1177/15357597251318577","url":null,"abstract":"<p><p>The increased risk for psychosocial burden and suicidality in people with epilepsy compared to the general population is a well-established global public health concern. Suicidality risk is also increased in patients with functional seizures. The timely identification of patients at highest risk for psychosocial burden and self-harm is vital. This can pose a significant challenge for multidisciplinary clinicians caring for people with epilepsy. Early identification of social stressors and comorbid psychiatric contributors via screening are required to assist with the development of predictive models for self-harm in epilepsy; and subsequent options for treatment and the provision of adjunct supports in the community may help lead to evidence-based suicide prevention strategies for people with epilepsy. Too often, pervasive and common social stressors leading to self-harm go unrecognized and undertreated. Elevating clinician awareness of patient subpopulations at highest risk for suicide, and informing on the advent of evidence-based self-management programs targeting depression and self-harm presents an opportunity to increase suicide prevention in epilepsy.</p>","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597251318577"},"PeriodicalIF":5.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-31DOI: 10.1177/15357597241311113
Eliane Kobayashi
{"title":"Genetic Networks of Drug Resistance in Epilepsy: Outputs of a Computational and Translational Disease Framework.","authors":"Eliane Kobayashi","doi":"10.1177/15357597241311113","DOIUrl":"10.1177/15357597241311113","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597241311113"},"PeriodicalIF":5.8,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-17DOI: 10.1177/15357597241309175
Sarah Yaser, Steve C Danzer
{"title":"A Tail Yet to be Told: The Fasciola Cinereum in Epilepsy.","authors":"Sarah Yaser, Steve C Danzer","doi":"10.1177/15357597241309175","DOIUrl":"10.1177/15357597241309175","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597241309175"},"PeriodicalIF":5.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-17DOI: 10.1177/15357597241311132
Anteneh M Feyissa
{"title":"Debunking the Myth: The Null Effect of Antiseizure Medications on the Functional Outcomes of Acute Symptomatic Seizures.","authors":"Anteneh M Feyissa","doi":"10.1177/15357597241311132","DOIUrl":"10.1177/15357597241311132","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597241311132"},"PeriodicalIF":5.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-15DOI: 10.1177/15357597241307833
Sarah F Muldoon PhD
{"title":"Breaking Balance: Synaptic Interneuron Properties Shift the E-I Balance in FCD I Epilepsy.","authors":"Sarah F Muldoon PhD","doi":"10.1177/15357597241307833","DOIUrl":"10.1177/15357597241307833","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597241307833"},"PeriodicalIF":5.8,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-07DOI: 10.1177/15357597241308665
Jennifer C Wong
{"title":"Knock, Knock, Who's There? Not <i>SCN1A</i> in Brain Organoids.","authors":"Jennifer C Wong","doi":"10.1177/15357597241308665","DOIUrl":"https://doi.org/10.1177/15357597241308665","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597241308665"},"PeriodicalIF":5.8,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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