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Epilepsy Currents最新文献

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Nav1.1gating Against the Current: Ndnf Interneurons Hold Strong in Dravet Syndrome. 逆流而上的 Nav1.1gating：Ndnf 内euron 在 Dravet 综合征中保持强势。
IF 5.8 2区 医学 Q1 CLINICAL NEUROLOGY
Epilepsy Currents
Pub Date : 2024-10-16 eCollection Date: 2024-11-01 DOI: 10.1177/15357597241284350
Yuliya Voskobiynyk, Jeanne T Paz
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引用次数: 0
When Considering Supplemental SEEG, Remember the Die is Cast Before the First Implantation. 在考虑补充 SEEG 时，请记住在第一次植入前就已经定型。
IF 5.8 2区 医学 Q1 CLINICAL NEUROLOGY
Epilepsy Currents
Pub Date : 2024-10-16 eCollection Date: 2024-11-01 DOI: 10.1177/15357597241280483
Vineet Punia
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引用次数: 0
Neuronal Excitability in Trisomy 21-Up or Down? 21 三体综合征的神经元兴奋性上升还是下降？
IF 5.8 2区 医学 Q1 CLINICAL NEUROLOGY
Epilepsy Currents
Pub Date : 2024-10-16 eCollection Date: 2024-11-01 DOI: 10.1177/15357597241285779
Carl E Stafstrom
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引用次数: 0
KCN Channels "Cue" Up GABA Release from Astrocytes. KCN 通道 "提示 "星形胶质细胞释放 GABA
IF 5.8 2区 医学 Q1 CLINICAL NEUROLOGY
Epilepsy Currents
Pub Date : 2024-10-16 eCollection Date: 2024-11-01 DOI: 10.1177/15357597241280504
Matthew C Weston
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引用次数: 0
The Need for Speed; Investigating Channelopathy-Associated Epilepsy Using High Throughput Electrophysiological Approaches. 需要速度；利用高通量电生理学方法研究通道病相关癫痫。
IF 5.8 2区 医学 Q1 CLINICAL NEUROLOGY
Epilepsy Currents
Pub Date : 2024-10-16 eCollection Date: 2024-09-01 DOI: 10.1177/15357597241280484
Alfred L George, Evangelos Kiskinis

Pathogenic variants in genes encoding ion channels are frequently discovered in monogenic disorders associated with epilepsy and neurodevelopmental disorders. This review covers advances in the use of automated patch clamp recording for determining the functional consequences of epilepsy-associated ion channel variants and the use of induced pluripotent stem cell (iPSC) derived neurons for in-depth investigations of the physiological consequences of such variants. The combination of these advanced technologies was a focus of the recently completed NINDS-funded Channelopathy-associated Epilepsy Research Center without Walls.

在与癫痫和神经发育障碍相关的单基因疾病中，经常会发现编码离子通道基因的致病变异。本综述介绍了使用自动膜片钳记录确定癫痫相关离子通道变异的功能性后果以及使用诱导多能干细胞（iPSC）衍生神经元深入研究此类变异的生理后果方面的进展。这些先进技术的结合是最近完成的由美国国家神经疾病研究所（NINDS）资助的无墙通道病相关癫痫研究中心（Channelopathy-associated Epilepsy Research Center without Walls）的工作重点。
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引用次数: 0
More is Different in mTORopathies. 在 mTOR 病症中，"更多 "就是 "不同"。
IF 5.8 2区 医学 Q1 CLINICAL NEUROLOGY
Epilepsy Currents
Pub Date : 2024-10-16 eCollection Date: 2024-09-01 DOI: 10.1177/15357597241280470
Yu Wang
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引用次数: 0
Are High-Frequency Activities Reliable Biomarkers of the FCDII Lesion? 高频活动是 FCDII 病变的可靠生物标志物吗？
IF 5.8 2区 医学 Q1 CLINICAL NEUROLOGY
Epilepsy Currents
Pub Date : 2024-10-15 eCollection Date: 2024-09-01 DOI: 10.1177/15357597241280482
Guru Prasad Padmasola, Gabriele Lignani
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引用次数: 0
Mitigating Risk, Optimizing Care: Antiseizure Medications, Pregnancy, and Autism Spectrum Disorder Risk. 降低风险，优化护理：抗癫痫药物、怀孕和自闭症谱系障碍风险。
IF 5.8 2区 医学 Q1 CLINICAL NEUROLOGY
Epilepsy Currents
Pub Date : 2024-10-15 eCollection Date: 2024-11-01 DOI: 10.1177/15357597241280479
Yi Li
{"title":"Mitigating Risk, Optimizing Care: Antiseizure Medications, Pregnancy, and Autism Spectrum Disorder Risk.","authors":"Yi Li","doi":"10.1177/15357597241280479","DOIUrl":"10.1177/15357597241280479","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"24 6","pages":"412-414"},"PeriodicalIF":5.8,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wnt Signaling: The Next Step on the Road to Anti-Epileptogenic Therapies? Wnt 信号：抗致痫疗法之路的下一步？
IF 5.8 2区 医学 Q1 CLINICAL NEUROLOGY
Epilepsy Currents
Pub Date : 2024-10-15 eCollection Date: 2024-09-01 DOI: 10.1177/15357597241280467
Carolina Moncion, Peter J West, Cameron S Metcalf
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引用次数: 0
Dopamine Dilemma Overexcites the Hippocampus in Alzheimer's Disease. 多巴胺困境会过度刺激阿尔茨海默病的海马体
IF 5.8 2区 医学 Q1 CLINICAL NEUROLOGY
Epilepsy Currents
Pub Date : 2024-10-15 eCollection Date: 2024-09-01 DOI: 10.1177/15357597241280475
Jennifer C Wong
{"title":"Dopamine Dilemma Overexcites the Hippocampus in Alzheimer's Disease.","authors":"Jennifer C Wong","doi":"10.1177/15357597241280475","DOIUrl":"10.1177/15357597241280475","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"24 5","pages":"361-363"},"PeriodicalIF":5.8,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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