Objective: Antibiotic resistance poses a major global public health threat. It compromises human health and increases healthcare burdens. The gut microbiota serves as a critical reservoir for antibiotic resistance genes (ARGs). It plays a pivotal role in the spread and evolution of antibiotic resistance. This study systematically analyzes the literature regarding on antibiotic resistance and gut microbiota from 1999 to 2024. It aims to elucidate global distribution, collaboration patterns, key contributors, current research hotspots, and future directions.
Methods: This study analyzes academic literature from the Web of Science Core Collection (1999-2024). VOSviewer was used to assess countries/regions, institutions, and co-cited journals for clustering and timeline visualizations. CiteSpace was employed to examine authors, co-cited authors, journals, references, and keywords for clustering, timeline visualizations, and burst detection. Additionally, Biblioshiny was used to create a global collaboration map of countries/regions.
Results: This global analysis included 4,863 articles from 132 countries/regions, over 5,700 institutions, and 26,931 authors. Recent years show a significant increase in publication volume. The study mapped the global distribution and identified key contributing countries, authors, and institutions. Current research hotspots focus on ARGs and immunotherapy. The findings highlight the need to address host-related factors, lifecycle-specific issues, regional research disparities, and antibiotic resistance pressures. Novel therapeutic approaches and their integration with environmental science require further exploration to advance resistance management.
Conclusion: This study is the first to use a systematic review to explore trends and emerging hotspots in antibiotic resistance and gut microbiota research. The identification of key contributors, including leading countries, institutions, authors, and journals, providing a foundation for advancing further collaboration and progress. It also highlights underexplored areas and potential future directions through a bibliometric perspective.
目的：抗生素耐药性是一项重大的全球公共卫生威胁。它危害人类健康，增加医疗负担。肠道菌群是抗生素耐药基因（ARGs）的重要储存库。它在抗生素耐药性的传播和进化中起着关键作用。本研究系统分析了1999 - 2024年有关抗生素耐药性和肠道菌群的文献。它旨在阐明全球分布、合作模式、主要贡献者、当前研究热点和未来发展方向。方法：对Web of Science Core Collection（1999-2024）的学术文献进行分析。使用VOSviewer对国家/地区、机构和共被引期刊进行聚类和时间轴可视化评估。使用CiteSpace来检查作者、共同被引作者、期刊、参考文献和关键字，以便进行聚类、时间线可视化和突发检测。此外，Biblioshiny还用于创建国家/地区的全球协作地图。结果：这项全球分析包括来自132个国家/地区、5700多家机构和26931位作者的4863篇文章。近年来，出版物数量显著增加。该研究绘制了全球分布地图，并确定了主要贡献国、作者和机构。目前的研究热点主要集中在ARGs和免疫治疗方面。研究结果强调需要解决与宿主相关的因素、生命周期特异性问题、区域研究差异和抗生素耐药压力。新的治疗方法及其与环境科学的结合需要进一步探索，以推进耐药性管理。结论：本研究首次采用系统综述的方法探讨了抗生素耐药性和肠道菌群研究的趋势和新兴热点。确定主要贡献者，包括主要国家、机构、作者和期刊，为进一步推进合作和进展奠定基础。它还通过文献计量学的角度强调了未开发的领域和潜在的未来方向。
{"title":"Mapping 25 years of research on gut microbiota and antibiotic resistance: bibliometric insights and future directions.","authors":"Yiwei Heng, Mengping Wang, Zhen Zhang, Enlin Jian, Chenchen Wu, Chengwei Zhang, Qing Chen, Xiaoping Yu, Yanfeng Zhu, Peiling Cai","doi":"10.1007/s10096-026-05455-y","DOIUrl":"https://doi.org/10.1007/s10096-026-05455-y","url":null,"abstract":"<p><strong>Objective: </strong>Antibiotic resistance poses a major global public health threat. It compromises human health and increases healthcare burdens. The gut microbiota serves as a critical reservoir for antibiotic resistance genes (ARGs). It plays a pivotal role in the spread and evolution of antibiotic resistance. This study systematically analyzes the literature regarding on antibiotic resistance and gut microbiota from 1999 to 2024. It aims to elucidate global distribution, collaboration patterns, key contributors, current research hotspots, and future directions.</p><p><strong>Methods: </strong>This study analyzes academic literature from the Web of Science Core Collection (1999-2024). VOSviewer was used to assess countries/regions, institutions, and co-cited journals for clustering and timeline visualizations. CiteSpace was employed to examine authors, co-cited authors, journals, references, and keywords for clustering, timeline visualizations, and burst detection. Additionally, Biblioshiny was used to create a global collaboration map of countries/regions.</p><p><strong>Results: </strong>This global analysis included 4,863 articles from 132 countries/regions, over 5,700 institutions, and 26,931 authors. Recent years show a significant increase in publication volume. The study mapped the global distribution and identified key contributing countries, authors, and institutions. Current research hotspots focus on ARGs and immunotherapy. The findings highlight the need to address host-related factors, lifecycle-specific issues, regional research disparities, and antibiotic resistance pressures. Novel therapeutic approaches and their integration with environmental science require further exploration to advance resistance management.</p><p><strong>Conclusion: </strong>This study is the first to use a systematic review to explore trends and emerging hotspots in antibiotic resistance and gut microbiota research. The identification of key contributors, including leading countries, institutions, authors, and journals, providing a foundation for advancing further collaboration and progress. It also highlights underexplored areas and potential future directions through a bibliometric perspective.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147467281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-16DOI: 10.1007/s10096-026-05464-x
Nikolaos Cholevas, Lucka Kuntner, Evgenij Potapov, Jan Knierim, Andrej Trampuz, Annette Moter, Judith Kikhney, Felix Schoenrath
{"title":"LVAD specific infection with Coxiella burnetii treated with heart transplantation and antibiotic suppression.","authors":"Nikolaos Cholevas, Lucka Kuntner, Evgenij Potapov, Jan Knierim, Andrej Trampuz, Annette Moter, Judith Kikhney, Felix Schoenrath","doi":"10.1007/s10096-026-05464-x","DOIUrl":"https://doi.org/10.1007/s10096-026-05464-x","url":null,"abstract":"","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147467343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-14DOI: 10.1007/s10096-026-05469-6
Alice Bonetti, Alessandro Amatu, Marta Corbella, Cristina Merla, Stefania Benedetti, Federico Capra Marzani, Fausto Baldanti, Patrizia Cambieri
{"title":"Clinical impact of Biofire FilmArray Pneumonia Plus Panel on diagnostic and therapeutic management of patients in intensive care unit: an observational retrospective study.","authors":"Alice Bonetti, Alessandro Amatu, Marta Corbella, Cristina Merla, Stefania Benedetti, Federico Capra Marzani, Fausto Baldanti, Patrizia Cambieri","doi":"10.1007/s10096-026-05469-6","DOIUrl":"https://doi.org/10.1007/s10096-026-05469-6","url":null,"abstract":"","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147456522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-13DOI: 10.1007/s10096-026-05465-w
María Paniagua-García, José Manuel Bernal, María Pilar Sánchez-Suero, Jerónimo Pachón, María Eugenia Pachón-Ibáñez, Antonio J Vallejo-Vaz, Elisa Cordero
{"title":"The clinical characteristics and outcomes of Campylobacter spp. bloodstream infection: A systematic review and meta-analysis.","authors":"María Paniagua-García, José Manuel Bernal, María Pilar Sánchez-Suero, Jerónimo Pachón, María Eugenia Pachón-Ibáñez, Antonio J Vallejo-Vaz, Elisa Cordero","doi":"10.1007/s10096-026-05465-w","DOIUrl":"https://doi.org/10.1007/s10096-026-05465-w","url":null,"abstract":"","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-06DOI: 10.1007/s10096-026-05426-3
Wenhua Zhao, Hui Li, Maoling Hu, Yuwei Ren, Yang Wang, Yingwang Ye
{"title":"Global, regional, and national burden of Clostridioides difficile infection (1990-2021) with projections to 2051: A multimodal analysis integrating machine learning (SHAP-XGBoost) and GBD 2021 data.","authors":"Wenhua Zhao, Hui Li, Maoling Hu, Yuwei Ren, Yang Wang, Yingwang Ye","doi":"10.1007/s10096-026-05426-3","DOIUrl":"https://doi.org/10.1007/s10096-026-05426-3","url":null,"abstract":"","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147364557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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