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Brief report: community-associated invasive infection caused by PVL-positive ST1232 (CC398) MRSA in a 15-year-old patient, Poland, 2024. 简要报告：波兰，2024年，一名15岁患者由pvl阳性ST1232 (CC398) MRSA引起的社区相关侵袭性感染。
IF 3 3区 医学 Q2 INFECTIOUS DISEASES
European Journal of Clinical Microbiology & Infectious Diseases
Pub Date : 2026-02-25 DOI: 10.1007/s10096-026-05444-1
Monika Orczykowska-Kotyna, Anna Pietruczuk-Padzik, Magdalena Mierzewska-Schmidt, Monika Wanke-Rytt, Aneta Mroczkowska, Dominik Nguyen, Izabela Pągowska-Klimek, Joanna Empel, Edyta Podsiadły
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引用次数: 0
Prevalence of Enterocytozoon bieneusi and Encephalitozoon spp. in Swedish patients with suspected gastrointestinal parasite infection: a cross-sectional molecular study. 在瑞典疑似胃肠道寄生虫感染的患者中，bieneusenterocyzoi和encephalitzoon的患病率：一项横断面分子研究。
IF 3 3区 医学 Q2 INFECTIOUS DISEASES
European Journal of Clinical Microbiology & Infectious Diseases
Pub Date : 2026-02-25 DOI: 10.1007/s10096-026-05443-2
Jessica Ögren, Anna J Henningsson, Silvia Botero-Kleiven, Andreas Matussek, Peter Wilhelmsson
{"title":"Prevalence of Enterocytozoon bieneusi and Encephalitozoon spp. in Swedish patients with suspected gastrointestinal parasite infection: a cross-sectional molecular study.","authors":"Jessica Ögren, Anna J Henningsson, Silvia Botero-Kleiven, Andreas Matussek, Peter Wilhelmsson","doi":"10.1007/s10096-026-05443-2","DOIUrl":"https://doi.org/10.1007/s10096-026-05443-2","url":null,"abstract":"","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Klebsiella pneumoniae sequence type 11 but not other virulence factors with patient mortality: a systematic review and meta-analysis. 肺炎克雷伯菌序列11型而非其他毒力因素与患者死亡率的关联：一项系统回顾和荟萃分析
IF 3 3区 医学 Q2 INFECTIOUS DISEASES
European Journal of Clinical Microbiology & Infectious Diseases
Pub Date : 2026-02-23 DOI: 10.1007/s10096-026-05438-z
Hiroki Namikawa, Ken-Ichi Oinuma, Yukihiro Kaneko, Hiroshi Kakeya, Taichi Shuto

Background: Klebsiella pneumoniae is a major cause of severe healthcare- and community-associated infections, and both hypervirulent and carbapenem-resistant forms are increasingly reported worldwide. However, the prognostic value of virulence factors remains uncertain. We conducted a systematic review and meta-analysis to evaluate their association with mortality.

Methods: We searched PubMed, Scopus, and Cochrane Library for studies (2000-2024) reporting virulence factors in K. pneumoniae infections. Meta-analysis compared the prevalence of factors reported in ≥ 5 studies between survivors and non-survivors.

Results: Sixteen studies including 2,697 patients (600 deaths, 22.2%) were analyzed. Common virulence factors included hypermucoviscous phenotype, rmpA, iucA, and K1/K2 capsular types. Only sequence type 11 (ST11) was associated with increased mortality in a random-effects meta-analysis (pooled OR 2.43; 95% CI: 1.03-5.77; P = 0.04). Sensitivity analyses confirmed this result's robustness, even among drug-resistant strains. No significant link between traditional virulence factors and mortality was found.

Conclusion: ST11 is a marker associated with increased mortality in K. pneumoniae infections, likely due to its strong link with carbapenem resistance. Antimicrobial resistance appears to influence patient outcomes more than intrinsic virulence factors. Integrating sequence typing and resistance profiles into molecular epidemiology may improve risk assessment and infection control strategies.

背景：肺炎克雷伯菌是严重的卫生保健和社区相关感染的主要原因，在世界范围内，高毒型和碳青霉烯耐药型的报道越来越多。然而，毒力因素的预后价值仍然不确定。我们进行了系统回顾和荟萃分析来评估它们与死亡率的关系。方法：检索PubMed、Scopus和Cochrane图书馆2000-2024年间报道肺炎克雷伯菌感染毒力因素的研究。荟萃分析比较了≥5项研究中幸存者和非幸存者之间报告的因素的患病率。结果：16项研究纳入2697例患者（死亡600例，22.2%）。常见的毒力因子包括高粘滞表型、rmpA、iucA和K1/K2荚膜类型。在随机效应荟萃分析中，只有序列类型11 （ST11）与死亡率增加相关（合并OR 2.43; 95% CI: 1.03-5.77; P = 0.04）。敏感性分析证实了这一结果的稳健性，即使在耐药菌株中也是如此。传统的毒力因素与死亡率之间没有明显的联系。结论：ST11是与肺炎克雷伯菌感染死亡率增加相关的标志物，可能是由于其与碳青霉烯类耐药性密切相关。抗菌素耐药性似乎比内在毒力因素更能影响患者的预后。将序列分型和耐药谱整合到分子流行病学中可以改进风险评估和感染控制策略。
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引用次数: 0
Lower prevalence of Blastocystis spp. and Dientamoeba fragilis in ulcerative colitis and association with disease activity. 溃疡性结肠炎中囊虫和脆弱地阿米巴患病率较低及其与疾病活动性的关系。
IF 3 3区 医学 Q2 INFECTIOUS DISEASES
European Journal of Clinical Microbiology & Infectious Diseases
Pub Date : 2026-02-23 DOI: 10.1007/s10096-026-05429-0
Mèlanie Valentina Bénard, Rens Zonneveld, Patricia Broekhuizen-van Haaften, Ellen M S Wentink-Bonnema, Sebastien Matamoros, Cyriel Y Ponsioen
{"title":"Lower prevalence of Blastocystis spp. and Dientamoeba fragilis in ulcerative colitis and association with disease activity.","authors":"Mèlanie Valentina Bénard, Rens Zonneveld, Patricia Broekhuizen-van Haaften, Ellen M S Wentink-Bonnema, Sebastien Matamoros, Cyriel Y Ponsioen","doi":"10.1007/s10096-026-05429-0","DOIUrl":"https://doi.org/10.1007/s10096-026-05429-0","url":null,"abstract":"","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147270007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic accuracy of septicyte rapid to discriminate sepsis from non-infectious critical illness in patients meeting sepsis criteria according to sepsis-3 definition at icu admission. 在icu入院时符合脓毒症-3定义的脓毒症患者中，败血症快速区分脓毒症与非感染性重症的诊断准确性。
IF 3 3区 医学 Q2 INFECTIOUS DISEASES
European Journal of Clinical Microbiology & Infectious Diseases
Pub Date : 2026-02-23 DOI: 10.1007/s10096-026-05431-6
María Luisa Cantón-Bulnes, José Luís García-Garmendia, Ángel Estella, Adela Fernández-Galilea, Isidro Blanco, María Antonia Estecha-Foncea, Marina Gordillo-Resina, Jorge Rodríguez-Gómez, Juan Jesús Pineda-Capitán, Carmen Martínez-Fernández, Ana Escoresca-Ortega, Rosario Amaya-Villar, Juan Mora-Ordóñez, Sara González-Soto, José Garnacho-Montero
{"title":"Diagnostic accuracy of septicyte rapid to discriminate sepsis from non-infectious critical illness in patients meeting sepsis criteria according to sepsis-3 definition at icu admission.","authors":"María Luisa Cantón-Bulnes, José Luís García-Garmendia, Ángel Estella, Adela Fernández-Galilea, Isidro Blanco, María Antonia Estecha-Foncea, Marina Gordillo-Resina, Jorge Rodríguez-Gómez, Juan Jesús Pineda-Capitán, Carmen Martínez-Fernández, Ana Escoresca-Ortega, Rosario Amaya-Villar, Juan Mora-Ordóñez, Sara González-Soto, José Garnacho-Montero","doi":"10.1007/s10096-026-05431-6","DOIUrl":"https://doi.org/10.1007/s10096-026-05431-6","url":null,"abstract":"","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel phage encoding host defense modulators demonstrates in-vivo therapeutic efficacy against carbapenem-resistant E. coli ST1432. 一种新的编码宿主防御调节剂的噬菌体在体内对耐碳青霉烯的大肠杆菌ST1432具有治疗效果。
IF 3 3区 医学 Q2 INFECTIOUS DISEASES
European Journal of Clinical Microbiology & Infectious Diseases
Pub Date : 2026-02-23 DOI: 10.1007/s10096-026-05422-7
Aylin Uskudar Guclu, Nisanur Ayas, Farzaneh Bonyadi, Sezin Unlu Celebi
{"title":"A novel phage encoding host defense modulators demonstrates in-vivo therapeutic efficacy against carbapenem-resistant E. coli ST1432.","authors":"Aylin Uskudar Guclu, Nisanur Ayas, Farzaneh Bonyadi, Sezin Unlu Celebi","doi":"10.1007/s10096-026-05422-7","DOIUrl":"https://doi.org/10.1007/s10096-026-05422-7","url":null,"abstract":"","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current status and future perspectives of fecal immunological markers in the differential diagnosis of Clostridioides difficile infection in children. 粪便免疫学标志物在儿童艰难梭菌感染鉴别诊断中的现状及未来展望。
IF 3 3区 医学 Q2 INFECTIOUS DISEASES
European Journal of Clinical Microbiology & Infectious Diseases
Pub Date : 2026-02-21 DOI: 10.1007/s10096-026-05424-5
Runjie Wang, Xiaolu Li, Ting Zhang
{"title":"Current status and future perspectives of fecal immunological markers in the differential diagnosis of Clostridioides difficile infection in children.","authors":"Runjie Wang, Xiaolu Li, Ting Zhang","doi":"10.1007/s10096-026-05424-5","DOIUrl":"https://doi.org/10.1007/s10096-026-05424-5","url":null,"abstract":"","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146776067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative evaluation of BacT/ALERT PF Plus and PF pediatric blood culture bottles: A dual in vitro and clinical retrospective study. BacT/ALERT PF Plus和PF儿科血培养瓶的比较评价：体外和临床双回顾性研究。
IF 3 3区 医学 Q2 INFECTIOUS DISEASES
European Journal of Clinical Microbiology & Infectious Diseases
Pub Date : 2026-02-20 DOI: 10.1007/s10096-026-05425-4
Shanshan Ma, Weilong Kong, Meng Duan, Fei Mo, Weiping Lu, Qiu Zhong

Purpose: Prompt diagnosis of pediatric bloodstream infections (BSI) is challenged by low blood volumes and prior antibiotic use. This study systematically evaluated the performance of the new-generation BacT/ALERT PF Plus pediatric blood culture bottle against the standard PF bottle.

Methods: This study combined in vitro verification using 16 common BSI pathogens to compare time to detection (TTD) and antibiotic neutralization, with a retrospective clinical study of 10,920 pediatric blood cultures from 2019 to 2024.

Results: In vitro, PF Plus bottles reduced median TTD by 2.39 h (P < 0.05) and demonstrated superior neutralization of ampicillin and vancomycin. Clinically, the transition to PF Plus increased the overall positivity rate (1.97% to 2.27%), significantly reduced median TTD by 4.06 h (P < 0.05), and expanded the pathogen spectrum to include key organisms like Staphylococcus aureus and non-fermenting bacteria. Blood volume analysis suggested a potential optimal range of 5.1-6.0 mL, while maintaining reliable performance at suboptimal volumes (< 1.0 mL).

Conclusion: The PF Plus bottle offers faster detection, enhanced antibiotic neutralization, and improved pathogen recovery. Despite limitations inherent to retrospective designs, our data support PF Plus as an enhanced diagnostic tool and provide preliminary reference values for pediatric blood sample volumes.

目的：儿科血流感染（BSI）的快速诊断受到低血容量和既往抗生素使用的挑战。本研究系统地评估了新一代BacT/ALERT PF Plus儿科血液培养瓶与标准PF瓶的性能。方法：本研究结合16种常见BSI病原体的体外验证，比较检测时间（TTD）和抗生素中和作用，并对2019年至2024年10920例儿科血培养进行回顾性临床研究。结果：在体外，PF Plus瓶可使中位TTD降低2.39 h (P)。结论：PF Plus瓶可加快检测速度，增强抗生素中和作用，提高病原体回收率。尽管回顾性设计存在固有的局限性，但我们的数据支持PF Plus作为增强的诊断工具，并为儿科血液样本量提供初步参考值。
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引用次数: 0
Correction to: In vitro emergence of amoxicillin-resistance and impact of amoxicillin on biofilm production across Cutibacterium acnes phylotypes? 修正：阿莫西林耐药性的体外出现和阿莫西林对痤疮表皮杆菌种型生物膜生成的影响？
IF 3 3区 医学 Q2 INFECTIOUS DISEASES
European Journal of Clinical Microbiology & Infectious Diseases
Pub Date : 2026-02-19 DOI: 10.1007/s10096-026-05442-3
L Ruffier d'Epenoux, K Rwayane, A Paquin, E Persyn, E Fayoux, C Hervochon, S Corvec
{"title":"Correction to: In vitro emergence of amoxicillin-resistance and impact of amoxicillin on biofilm production across Cutibacterium acnes phylotypes?","authors":"L Ruffier d'Epenoux, K Rwayane, A Paquin, E Persyn, E Fayoux, C Hervochon, S Corvec","doi":"10.1007/s10096-026-05442-3","DOIUrl":"https://doi.org/10.1007/s10096-026-05442-3","url":null,"abstract":"","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146225938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A systematic review of data on the resistance of uropathogens to sulopenem. 尿路病原菌对苏洛培南耐药数据的系统综述。
IF 3 3区 医学 Q2 INFECTIOUS DISEASES
European Journal of Clinical Microbiology & Infectious Diseases
Pub Date : 2026-02-18 DOI: 10.1007/s10096-026-05420-9
Matthew E Falagas, Dimitrios S Kontogiannis, Dimitrios Ragias, Charalampos Filippou
{"title":"A systematic review of data on the resistance of uropathogens to sulopenem.","authors":"Matthew E Falagas, Dimitrios S Kontogiannis, Dimitrios Ragias, Charalampos Filippou","doi":"10.1007/s10096-026-05420-9","DOIUrl":"https://doi.org/10.1007/s10096-026-05420-9","url":null,"abstract":"","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146212410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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