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The Difference in Neutrophil-Lymphocyte Ratio (NLR), Platelet-Lymphocyte Ratio (PLR), and Lactate Levels Between Sepsis and Septic Shock Patients Who Died in The ICU ICU死亡脓毒症与感染性休克患者中性粒细胞-淋巴细胞比率(NLR)、血小板-淋巴细胞比率(PLR)及乳酸水平的差异
Pub Date : 2023-07-29 DOI: 10.20473/ijar.v5i22023.64-71
D. Rachmawati, Arie Utariani, P. B. Notopuro, B. Semedi
Introduction: Sepsis and septic shock are organ dysfunctions caused by the dysregulation of the body's response to infection and are the most common causes of death. Objective: This study aims to describe the neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and lactate levels in patients with sepsis and septic shock who died in the Intensive Care Unit (ICU). Materials and Methods: An observational retrospective study was conducted by examining the medical record data of sepsis and sepsis shock patients who were hospitalized in the ICU of Dr. Soetomo General Academic Hospital Surabaya from January to December 2019. Results: The study sample was 28 patients: 16 with sepsis and 12 with septic shock. Fifteen patients (53.6%) were women. The patients’ mean age was 53.18 ± 13.61 years, and most patients (8 patients, 28.6%) belonged to the late adult age group (36-45 years). The most common comorbidities were diabetes mellitus and hypertension (30.8%). The highest incidence of infection in both groups occurred in the lungs (42.9%). Most of the patients had high SOFA scores, in the moderate (7-9) to severe (≥ 10) category (39.3%). Almost all patients (82.1%) were treated for less than one week. The hematological examination within the first 24 hours showed a leukocyte value of 16,995 (Leukocytosis) and a platelet value of 279,500 (Normal). The NLR of septic shock patients (31.38±55.61) was higher than the NLR of sepsis patients (23.75±22.87). The PLR of septic shock patients (534.02±1000.67) was lower than the PLR of patients (802.93±1509.89). Lastly, the lactate levels in septic shock patients (3.84±1.99) were higher than in sepsis patients (1.97±1.06). Conclusion: There were no significant differences in the NLR and PLR values ​​between sepsis and septic shock patients, but there were significant differences in their initial lactate levels.
败血症和感染性休克是由机体对感染反应失调引起的器官功能障碍,是最常见的死亡原因。目的:本研究旨在探讨重症监护病房(ICU)死亡的脓毒症和感染性休克患者的中性粒细胞-淋巴细胞比率、血小板-淋巴细胞比率和乳酸水平。材料与方法:对2019年1 - 12月在泗水Soetomo综合学术医院ICU住院的脓毒症和脓毒症休克患者的病历资料进行观察性回顾性研究。结果:研究样本为28例患者:16例败血症,12例感染性休克。女性15例(53.6%)。患者平均年龄为53.18±13.61岁,其中36 ~ 45岁为晚期成人(8例,28.6%)。最常见的合并症是糖尿病和高血压(30.8%)。两组感染发生率最高的部位为肺部(42.9%)。大多数患者SOFA评分较高,分为中度(7-9分)至重度(≥10分)(39.3%)。几乎所有患者(82.1%)的治疗时间小于1周。24小时内的血液学检查显示白细胞值为16,995(白细胞增多),血小板值为279,500(正常)。脓毒性休克患者NLR(31.38±55.61)高于脓毒症患者NLR(23.75±22.87)。感染性休克患者的PLR(534.02±1000.67)低于患者的PLR(802.93±1509.89)。脓毒症休克患者乳酸水平(3.84±1.99)高于脓毒症患者(1.97±1.06)。结论:脓毒症与感染性休克患者NLR、PLR值差异无统计学意义,但初始乳酸水平差异有统计学意义。
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引用次数: 0
Opioid-Free Anesthesia in Ophthalmic Surgeries 无阿片类药物在眼科手术中的应用
Pub Date : 2023-07-29 DOI: 10.20473/ijar.v5i22023.81-87
A. Tantri, H. Angkasa, Riyadh Firdaus, Tasya Claudia, Ignatia Novita Tantri
Introduction: Opioid-free anesthesia (OFA) is an alternative to Opioid based anesthesia (OBA) which uses multimodal analgesia to replace opioids. However, its feasibility, safety, and exact recommended combination remain debatable. Case Series: We administered OFA in 5 types of elective ophthalmic surgeries under general anesthesia in ASA 1-2 adult patients (evisceration, ocular exenteration, periosteal graft, scleral buckling, vitrectomy, and dacryocystorhinostomy) to assess the feasibility of OFA. We gave preoperative Paracetamol and Pregabalin with Dexmedetomidine as a loading dose (1 mcg/kg in 10 minutes) and maintenance at 0.7 mcg kg-1 per hour. Induction was performed using Propofol 1-2 mg kg-1, Lidocaine 1-1.5 mg kg-1 IV, and Rocuronium. Before the incision, Dexamethasone and Ranitidine were given. Maintenance was done using Dexmedetomidine and Sevoflurane. Fentanyl was used as rescue analgesia if required. Dexmedetomidine was stopped 15-30 minutes before the procedure ended. Metoclopramide and Ketorolac were given as postoperative management. Throughout the procedure, our patients had stable hemodynamics, did not experience life-threatening bradycardia, and did not require rescue analgesia. All patients regained full consciousness and did not experience postoperative nausea and vomiting, emergency delirium, or coughing. Conclusion: Multimodal analgesia was an excellent intraoperative OFA regimen as an alternative to OBA and provided controlled hypotension in ocular surgery. Safe OFA is possible with combined analgesia regimens, strict intraoperative monitoring, and adequate anesthesia depth.
无阿片类药物麻醉(OFA)是阿片类药物麻醉(OBA)的一种替代方案,它使用多模态镇痛来替代阿片类药物。然而,其可行性、安全性和确切的推荐组合仍有争议。病例系列:我们对ASA 1-2例成人患者在全麻下进行了5种选择性眼科手术(剜骨、剜眼、骨膜移植、巩膜扣带、玻璃体切除术和泪囊鼻腔造口术),以评估OFA的可行性。术前给予扑热息痛、普瑞巴林和右美托咪定负荷剂量(10分钟1 mcg/kg),维持每小时0.7 mcg kg-1。诱导使用异丙酚1 ~ 2 mg kg-1、利多卡因1 ~ 1.5 mg kg-1 IV、罗库溴铵。切口前给予地塞米松、雷尼替丁。维持使用右美托咪定和七氟醚。必要时使用芬太尼作为救急镇痛。右美托咪定在手术结束前15-30分钟停用。术后给予甲氧氯普胺和酮咯酸。在整个手术过程中,我们的患者血流动力学稳定,没有出现危及生命的心动过缓,也不需要急救镇痛。所有患者均恢复完全意识,术后未出现恶心呕吐、紧急谵妄或咳嗽。结论:在眼科手术中,多模式镇痛是一种较好的术中OFA方案,可替代OBA,提供可控的低血压。安全OFA是可能的联合镇痛方案,严格的术中监测和足够的麻醉深度。
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引用次数: 0
Validation of the APACHE IV Score for ICU Mortality Prediction in Dr. Sardjito Hospital During the Pandemic Era APACHE IV评分在大流行时期预测Dr. Sardjito医院ICU死亡率的验证
Pub Date : 2023-07-29 DOI: 10.20473/ijar.v5i22023.72-80
Rayhandika, A. Y. Jufan, Y. Widyastuti, J. Kurniawaty
Introduction: ICU service quality must continuously improve to provide better patient service. One of these improvement efforts is the use of a risk prediction system to predict mortality rates in the ICU by utilizing risk factors. This system helps healthcare services perform evaluations and comparative audits of intensive services, which can also aid with more targeted planning. APACHE IV is considered to have good validity. However, its predictive capabilities may change over time due to various factors, such as the pandemic, where changes in the case mix may affect its predictive abilities. Therefore, this research tests the validity of APACHE IV on the Indonesian population through Dr. Sardjito Hospital patients. The findings can be utilized for future use and risk stratification, and ICU quality benchmarking. Objectives: This study aims to assess the validity of the APACHE IV score in ICU Mortality prediction in Dr. Sardjito Hospital for medical patients, surgical patients, and patients with both cases during the pandemic. Materials and Method: This study used retrospective data from 336 patients at Dr. Sardjito Hospital Yogyakarta from the 1st of January 2020 to the 31st of December 2021. All data required for calculating the APACHE IV score was collected, and the patient’s observed ICU Mortality was used. The model’s predictive validity is measured by finding the discrimination and calibration of the APACHE IV score and comparing it to the observed ICU mortality. Validation was also conducted separately for medical and surgical cases. Results: APACHE IV shows good discrimination ability in all cases (AUC-ROC 95% CI: 0.819 [0.772-0.866]) but poor calibration (p = 0.023) for mortality prediction in the ICU. For medical cases, the discrimination ability is poor but still acceptable (AUC-ROC 95% CI: 0.698 [0.614-0.782]), and in surgical cases, the discrimination ability is good (AUC-ROC 95% CI: 0.848 [0.776-0.921]). Both cases showed good calibration (p: medical = 0.569, surgical = 0.579) in predicting mortality during the pandemic. Conclusion: APACHE IV showed good discrimination but poor calibration ability for predicting mortality for all ICU patients during the pandemic era. Mortality prediction for surgical cases showed good discrimination and calibration. However, medical cases showed poor discrimination but good calibration.
导读:ICU服务质量必须不断提高,才能为患者提供更好的服务。其中一项改进工作是使用风险预测系统通过利用危险因素来预测ICU的死亡率。该系统可帮助医疗服务机构对密集服务进行评估和比较审计,这也有助于制定更有针对性的计划。APACHE IV被认为具有良好的有效性。然而,它的预测能力可能会随着时间的推移而改变,因为各种因素,例如大流行,病例组合的变化可能会影响其预测能力。因此,本研究通过Dr. Sardjito医院的患者来检验APACHE IV对印尼人群的有效性。研究结果可用于未来的使用和风险分层,以及ICU质量基准。目的:本研究旨在评估APACHE IV评分在大流行期间Sardjito博士医院内科患者、外科患者和两种病例患者的ICU死亡率预测中的有效性。材料和方法:本研究使用了2020年1月1日至2021年12月31日在日惹Dr. Sardjito医院的336名患者的回顾性数据。收集计算APACHE IV评分所需的所有数据,并使用患者观察到的ICU死亡率。该模型的预测效度是通过发现APACHE IV评分的鉴别性和校准来衡量的,并将其与观察到的ICU死亡率进行比较。还分别对内科病例和外科病例进行了验证。结果:APACHE IV在所有病例中均具有良好的鉴别能力(AUC-ROC 95% CI: 0.819[0.772-0.866]),但在预测ICU死亡率方面校准较差(p = 0.023)。对于内科病例,识别能力较差,但仍可接受(AUC-ROC 95% CI: 0.698[0.614-0.782]),对于外科病例,识别能力较好(AUC-ROC 95% CI: 0.848[0.776-0.921])。这两种情况在预测大流行期间的死亡率方面都显示出良好的校准(p:医学= 0.569,外科= 0.579)。结论:APACHE IV对大流行时期所有ICU患者的死亡率预测具有较好的判别能力,但校准能力较差。手术病例死亡率预测具有良好的判别性和校准性。但在医学案例中,辨别性差,校正性好。
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引用次数: 0
Association Between Shock Index and Post-Emergency Intubation Hypotension in Patients Who Called the Rapid Response Team at Dr. Cipto Mangunkusumo Hospital 呼叫Dr. Cipto Mangunkusumo医院快速反应小组的患者休克指数与急诊后插管低血压的关系
Pub Date : 2023-01-20 DOI: 10.20473/ijar.v5i12023.27-36
Herlina Rahmah, A. Adisasmita, S. Manggala, A. Sugiarto, Fadiah Zahrina, Prita Rosdiana
Introduction: Hypotension is an acute complication following Emergency Endotracheal Intubation (ETI) in populations who called the Rapid Response Team (RRT). Thus, a fast and simple tool is needed to identify the risk of Post-emergency Intubation Hypotension (PIH). Shock Index (SI) pre-intubation is one of the potential factors to predict PIH. Objective: To measure the association between shock index with post-emergency intubation hypotension after calling for the RRT. Materials and Methods: This research is a cohort retrospective study that analyzed 171 patients aged ≥18 years who have called RRT and underwent an emergency ETI. The cut-off point for SI was determined using the ROC curve to predict PIH. The modification effect was evaluated using stratification analysis. Data were analyzed using cox regression to determine the likelihood of SI in the cause of hypotension. Result: A total of 92 patients (53.8%) underwent post-emergency intubation hypotension. The SI cut-off point of 0.9 had a sensitivity of 82.6% and a specificity of 67.1% for predicting PIH (Area Under Curve (AUC) 0.81; 95% CI 0.754–0.882, p <0.05). The increased risk of PIH associated with high SI score was an aRR of 1.9; 95% CI 1.03–3.57, a p-value of 0.040 among those with sepsis, and an aRR of 7.9, 95% CI 2.36–26.38, a p-value of 0.001 among those without sepsis. Conclusion: This study showed that a high SI score was associated with PIH after being controlled with other PIH risk variables. The risk of PIH associated with SI score modestly increased (2-fold increase) in those with sepsis and significantly increased (8-fold increase) in those without sepsis.
简介:低血压是紧急气管插管(ETI)后的急性并发症,在呼叫快速反应小组(RRT)的人群中。因此,需要一种快速而简单的工具来识别急诊后插管低血压(PIH)的风险。插管前休克指数(SI)是预测PIH的潜在因素之一。目的:探讨休克指数与呼入RRT后急诊插管低血压的关系。材料和方法:本研究是一项队列回顾性研究,分析了171例年龄≥18岁的RRT和急诊ETI患者。用ROC曲线预测PIH,确定SI的分界点。采用分层分析法评价改性效果。使用cox回归分析数据,以确定SI在低血压原因中的可能性。结果:92例患者(53.8%)急诊后插管降压。SI截断点为0.9,预测PIH的敏感性为82.6%,特异性为67.1%(曲线下面积(AUC) 0.81;95% CI 0.754 ~ 0.882, p <0.05)。高SI评分与PIH风险增加相关的aRR为1.9;脓毒症患者的95% CI为1.03-3.57,p值为0.040;无脓毒症患者的aRR为7.9,95% CI为2.36-26.38,p值为0.001。结论:本研究表明,在与其他PIH风险变量控制后,高SI评分与PIH相关。脓毒症患者与SI评分相关的PIH风险适度增加(增加2倍),无脓毒症患者的PIH风险显著增加(增加8倍)。
{"title":"Association Between Shock Index and Post-Emergency Intubation Hypotension in Patients Who Called the Rapid Response Team at Dr. Cipto Mangunkusumo Hospital","authors":"Herlina Rahmah, A. Adisasmita, S. Manggala, A. Sugiarto, Fadiah Zahrina, Prita Rosdiana","doi":"10.20473/ijar.v5i12023.27-36","DOIUrl":"https://doi.org/10.20473/ijar.v5i12023.27-36","url":null,"abstract":"Introduction: Hypotension is an acute complication following Emergency Endotracheal Intubation (ETI) in populations who called the Rapid Response Team (RRT). Thus, a fast and simple tool is needed to identify the risk of Post-emergency Intubation Hypotension (PIH). Shock Index (SI) pre-intubation is one of the potential factors to predict PIH. Objective: To measure the association between shock index with post-emergency intubation hypotension after calling for the RRT. Materials and Methods: This research is a cohort retrospective study that analyzed 171 patients aged ≥18 years who have called RRT and underwent an emergency ETI. The cut-off point for SI was determined using the ROC curve to predict PIH. The modification effect was evaluated using stratification analysis. Data were analyzed using cox regression to determine the likelihood of SI in the cause of hypotension. Result: A total of 92 patients (53.8%) underwent post-emergency intubation hypotension. The SI cut-off point of 0.9 had a sensitivity of 82.6% and a specificity of 67.1% for predicting PIH (Area Under Curve (AUC) 0.81; 95% CI 0.754–0.882, p <0.05). The increased risk of PIH associated with high SI score was an aRR of 1.9; 95% CI 1.03–3.57, a p-value of 0.040 among those with sepsis, and an aRR of 7.9, 95% CI 2.36–26.38, a p-value of 0.001 among those without sepsis. Conclusion: This study showed that a high SI score was associated with PIH after being controlled with other PIH risk variables. The risk of PIH associated with SI score modestly increased (2-fold increase) in those with sepsis and significantly increased (8-fold increase) in those without sepsis.","PeriodicalId":117902,"journal":{"name":"Indonesian Journal of Anesthesiology and Reanimation","volume":"215 S681","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120852138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Administration of Nitrates After Spontaneous Delivery in Rheumatic Heart Disease 风湿性心脏病自然分娩后硝酸盐的应用
Pub Date : 2023-01-20 DOI: 10.20473/ijar.v5i12023.45-50
Mirza Koeshardiandi, Muhammad Wildan Afif Himawan, Fajar Perdhana, Zulfikar Loka Wicaksana
Introduction: Heart disease is one of the most common causes of maternal death. The incidence has increased since women with congenital and acquired heart disease reached fertile age. The circulation system changes during pregnancy which are induced by changes in the progesterone. The changes in progesterone levels increase heart work and cause death in pregnant women. Objective: This report aims to elaborate on the administration of nitrates as the management of labor in rheumatic heart disease (RHD). Case Report: A 27-year-old woman complained of shortness of breath and wanted to give birth. The patient was 38 weeks pregnant and had a history of heart disease. Antero-posterior chest radiography examination showed pulmonary edema and cardiomegaly. The patient was examined using echocardiography before spontaneous labor and was diagnosed as pregnant with rheumatic heart disease. As an emergency management, the patient was given painless spontaneous labor. The patient was given nitrates on the first day after delivery as a treatment for progesterone withdrawal syndrome in this case. After the delivery process was completed, the patient was admitted to the Intensive Care Unit (ICU). Discussion: Progesterone hormone produced by the corpus luteum and the placenta until the eighth week of pregnancy and before delivery, respectively, can reduce systemic vascular resistance. Progesterone hormone increase causes peripheral vasodilation by affecting the function of endothelial nitric oxide synthase (eNOS) and nitrite oxide (NO) production. Conclusion: A pregnant woman with rheumatic heart disease can be given exogenous nitrate. Administration of exogenous nitrates in this patient successfully prevent the reduction of peripheral vascular resistance and postpartum hemodynamic instability because it can replace the reduction in nitric oxide caused by progesterone withdrawal.
导言:心脏病是孕产妇死亡的最常见原因之一。自患有先天性和后天性心脏病的妇女达到生育年龄以来,发病率有所增加。怀孕期间循环系统的变化是由孕激素的变化引起的。孕激素水平的变化会增加孕妇的心脏工作,并导致死亡。目的:本报告旨在阐述硝酸盐在风湿性心脏病(RHD)分娩管理中的应用。病例报告:一名27岁妇女主诉呼吸短促,欲分娩。患者怀孕38周,有心脏病史。胸部前后x线检查显示肺水肿和心脏肿大。患者在自然分娩前接受超声心动图检查,诊断为风湿性心脏病孕妇。作为紧急处理,患者给予无痛自然分娩。患者在分娩后第一天给予硝酸盐作为治疗黄体酮戒断综合征。分娩过程完成后,患者被送入重症监护病房(ICU)。讨论:黄体和胎盘分别在妊娠第八周和分娩前产生的黄体酮激素可降低全身血管阻力。孕激素升高通过影响内皮一氧化氮合酶(eNOS)的功能和一氧化亚硝酸盐(NO)的生成而引起外周血管舒张。结论:风湿性心脏病孕妇可给予外源性硝酸盐治疗。在该患者中,外源性硝酸盐的使用成功地防止了周围血管阻力的降低和产后血流动力学的不稳定,因为它可以取代黄体酮停药引起的一氧化氮的降低。
{"title":"Administration of Nitrates After Spontaneous Delivery in Rheumatic Heart Disease","authors":"Mirza Koeshardiandi, Muhammad Wildan Afif Himawan, Fajar Perdhana, Zulfikar Loka Wicaksana","doi":"10.20473/ijar.v5i12023.45-50","DOIUrl":"https://doi.org/10.20473/ijar.v5i12023.45-50","url":null,"abstract":"Introduction: Heart disease is one of the most common causes of maternal death. The incidence has increased since women with congenital and acquired heart disease reached fertile age. The circulation system changes during pregnancy which are induced by changes in the progesterone. The changes in progesterone levels increase heart work and cause death in pregnant women. Objective: This report aims to elaborate on the administration of nitrates as the management of labor in rheumatic heart disease (RHD). Case Report: A 27-year-old woman complained of shortness of breath and wanted to give birth. The patient was 38 weeks pregnant and had a history of heart disease. Antero-posterior chest radiography examination showed pulmonary edema and cardiomegaly. The patient was examined using echocardiography before spontaneous labor and was diagnosed as pregnant with rheumatic heart disease. As an emergency management, the patient was given painless spontaneous labor. The patient was given nitrates on the first day after delivery as a treatment for progesterone withdrawal syndrome in this case. After the delivery process was completed, the patient was admitted to the Intensive Care Unit (ICU). Discussion: Progesterone hormone produced by the corpus luteum and the placenta until the eighth week of pregnancy and before delivery, respectively, can reduce systemic vascular resistance. Progesterone hormone increase causes peripheral vasodilation by affecting the function of endothelial nitric oxide synthase (eNOS) and nitrite oxide (NO) production. Conclusion: A pregnant woman with rheumatic heart disease can be given exogenous nitrate. Administration of exogenous nitrates in this patient successfully prevent the reduction of peripheral vascular resistance and postpartum hemodynamic instability because it can replace the reduction in nitric oxide caused by progesterone withdrawal.","PeriodicalId":117902,"journal":{"name":"Indonesian Journal of Anesthesiology and Reanimation","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115976997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Basic Life Support Training: The Effectiveness and Retention of The Distance-Learning Method 基本生命支持训练:远程学习方法的有效性和保留性
Pub Date : 2023-01-20 DOI: 10.20473/ijar.v5i12023.18-26
Rifdhani Fakhrudin Nur, Erlangga Prasamya, Arief Ikhwandi, P. Utomo, Sudadi
Introduction: Basic Life Support (BLS) training during the COVID-19 pandemic needed to be effective as well as prevent disease transmission between trainers and participants. The distance-learning method is one of the recommended modified training methods. However, there is still limited research that evaluates the effectiveness of the distance-learning method for BLS training for laypersons during the COVID-19 pandemic. Objective: To evaluate the effectiveness and retention of the distance-learning method for BLS training in improving the participant’s knowledge and skills. Materials and Methods: This is a non-randomized quasi-experimental study (one group pre-test and post-test design). A total of 64 TAGANA (Taruna Siaga Bencana/disaster volunteer) members of Sleman Regency who had undergone the distance learning method for BLS training were the participants of this study. A knowledge questionnaire and observation checklist were prepared and tested for context validity by an expert group. Data on the participant’s knowledge were collected before and after the training session, and data on the participant’s skills were recorded after the training session. After the training, a social media group was created to provide a periodical refresher of the BLS materials and facilitate discussions between the speakers and the study’s samples. Data on knowledge retention and skills were recorded six months post-training. Results: The distance-learning method for BLS training effectively increased the participants' knowledge of BLS, indicated by a significantly higher final knowledge score than before the training (Z=-6.904, p <0.001). The method also provided sufficient BLS skills, indicated by most of the samples (93.7%) passing the skill observation test even though no participant had attended a similar training before. Moreover, the participant’s knowledge and skills scores were significantly lower six months after the training session than immediately after training (Z=-5.157, p <0.001; Z=-4.219, p <0.001). Conclusion: The distance-learning method for BLS training effectively increased the participant’s BLS knowledge and skills. However, their knowledge and skills decreased at six months post-training. Overall, the distance-learning method has been proven as a promising alternative to BLS training during and after the COVID-19 pandemic.
导言:COVID-19大流行期间的基本生命支持(BLS)培训需要有效,并防止培训人员和参与者之间的疾病传播。远程学习方法是一种被推荐的改良训练方法。然而,在COVID-19大流行期间,评估远程学习方法对非专业人员进行劳工统计局培训的有效性的研究仍然有限。目的:评价远程学习方法在劳工统计局培训中提高被试知识和技能的有效性和保持性。材料与方法:本研究为非随机准实验研究(一组前测和后测设计)。本研究以64名接受过BLS远程学习培训的Sleman Regency的TAGANA (Taruna Siaga benana /disaster volunteer)成员为研究对象。准备了知识问卷和观察清单,并由专家组进行了上下文效度测试。在培训之前和之后收集参与者的知识数据,在培训之后记录参与者的技能数据。培训结束后,成立了一个社交媒体小组,定期更新劳工统计局的材料,并促进演讲者与研究样本之间的讨论。培训后6个月记录知识保留和技能的数据。结果:远程学习方式的BLS训练有效提高了被试对BLS的知识,最终知识得分显著高于训练前(Z=-6.904, p <0.001)。该方法还提供了足够的劳工统计局技能,大多数样本(93.7%)通过了技能观察测试,即使参与者之前没有参加过类似的培训。此外,参与者的知识和技能得分在培训后6个月显著低于培训后立即(Z=-5.157, p <0.001;Z=-4.219, p <0.001)。结论:远程学习方式的劳工统计局培训有效地提高了被试的劳工统计局知识和技能。然而,他们的知识和技能在培训后六个月有所下降。总体而言,在2019冠状病毒病大流行期间和之后,远程学习方法已被证明是一种有希望的替代劳工统计局培训的方法。
{"title":"Basic Life Support Training: The Effectiveness and Retention of The Distance-Learning Method","authors":"Rifdhani Fakhrudin Nur, Erlangga Prasamya, Arief Ikhwandi, P. Utomo, Sudadi","doi":"10.20473/ijar.v5i12023.18-26","DOIUrl":"https://doi.org/10.20473/ijar.v5i12023.18-26","url":null,"abstract":"Introduction: Basic Life Support (BLS) training during the COVID-19 pandemic needed to be effective as well as prevent disease transmission between trainers and participants. The distance-learning method is one of the recommended modified training methods. However, there is still limited research that evaluates the effectiveness of the distance-learning method for BLS training for laypersons during the COVID-19 pandemic. Objective: To evaluate the effectiveness and retention of the distance-learning method for BLS training in improving the participant’s knowledge and skills. Materials and Methods: This is a non-randomized quasi-experimental study (one group pre-test and post-test design). A total of 64 TAGANA (Taruna Siaga Bencana/disaster volunteer) members of Sleman Regency who had undergone the distance learning method for BLS training were the participants of this study. A knowledge questionnaire and observation checklist were prepared and tested for context validity by an expert group. Data on the participant’s knowledge were collected before and after the training session, and data on the participant’s skills were recorded after the training session. After the training, a social media group was created to provide a periodical refresher of the BLS materials and facilitate discussions between the speakers and the study’s samples. Data on knowledge retention and skills were recorded six months post-training. Results: The distance-learning method for BLS training effectively increased the participants' knowledge of BLS, indicated by a significantly higher final knowledge score than before the training (Z=-6.904, p <0.001). The method also provided sufficient BLS skills, indicated by most of the samples (93.7%) passing the skill observation test even though no participant had attended a similar training before. Moreover, the participant’s knowledge and skills scores were significantly lower six months after the training session than immediately after training (Z=-5.157, p <0.001; Z=-4.219, p <0.001). Conclusion: The distance-learning method for BLS training effectively increased the participant’s BLS knowledge and skills. However, their knowledge and skills decreased at six months post-training. Overall, the distance-learning method has been proven as a promising alternative to BLS training during and after the COVID-19 pandemic.","PeriodicalId":117902,"journal":{"name":"Indonesian Journal of Anesthesiology and Reanimation","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133450789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regional Anesthesia Subarachnoid Blockade (RASAB) in Scoliosis Patients 区域麻醉蛛网膜下腔阻滞(RASAB)在脊柱侧凸患者中的应用
Pub Date : 2023-01-20 DOI: 10.20473/ijar.v5i12023.51-63
Eko Setijanto, Kiel Pino Putra
Introduction: Scoliosis is a three-dimensional spinal deformity that is mainly determined based on the lateral curvature of the spine. Furthermore, regional anesthesia often infiltrates the peripheral nerves with an anesthetic agent and blocks transmission to avoid or relieve pain. A previous study revealed that scoliosis in patients is one of the factors affecting the success of spinal anesthesia. Objective: To obtain a theoretical basis that can support the solution to the RASAB problem. The acceptance of the theory is the first step to providing a better understanding of the study problem based on the scientific framework of thinking. Furthermore, the similarities, differences, and views of several pieces of literature that discussed related issues were evaluated in this review. Review: Regional anesthesia subarachnoid blockade (RASAB) or spinal anesthesia, is a procedure, which involves the administration of local anesthetic drugs into the subarachnoid space. Furthermore, the process is carried out between the lumbar (L) vertebrae L2-L3, L3-L4, or L4-L5. Spinal anesthesia is often used in surgical procedures involving the lower abdomen, pelvis, perineum, and lower extremities. Summary: In the setting of scoliosis, spinal anesthesia is challenging, but is not an absolute contraindication. Patients with scoliosis have unique characteristics, hence, anesthetists need to understand the impact of the disease on the body.
简介:脊柱侧凸是一种三维脊柱畸形,主要由脊柱的侧曲度决定。此外,区域麻醉通常用麻醉剂浸润周围神经并阻断传递以避免或减轻疼痛。既往研究表明脊柱侧凸是影响脊髓麻醉成功的因素之一。目的:为解决RASAB问题提供理论依据。接受这一理论是在科学思维框架的基础上更好地理解研究问题的第一步。此外,本文还对讨论相关问题的几篇文献的异同和观点进行了评价。回顾:区域麻醉蛛网膜下腔阻滞(RASAB)或脊髓麻醉是一种将局部麻醉药物注入蛛网膜下腔的过程。此外,该过程在腰椎L2-L3、L3-L4或L4-L5之间进行。脊髓麻醉常用于涉及下腹、骨盆、会阴和下肢的外科手术。摘要:在脊柱侧凸的情况下,脊髓麻醉是具有挑战性的,但不是绝对的禁忌症。脊柱侧凸患者具有独特的特点,因此,麻醉师需要了解疾病对身体的影响。
{"title":"Regional Anesthesia Subarachnoid Blockade (RASAB) in Scoliosis Patients","authors":"Eko Setijanto, Kiel Pino Putra","doi":"10.20473/ijar.v5i12023.51-63","DOIUrl":"https://doi.org/10.20473/ijar.v5i12023.51-63","url":null,"abstract":"Introduction: Scoliosis is a three-dimensional spinal deformity that is mainly determined based on the lateral curvature of the spine. Furthermore, regional anesthesia often infiltrates the peripheral nerves with an anesthetic agent and blocks transmission to avoid or relieve pain. A previous study revealed that scoliosis in patients is one of the factors affecting the success of spinal anesthesia. Objective: To obtain a theoretical basis that can support the solution to the RASAB problem. The acceptance of the theory is the first step to providing a better understanding of the study problem based on the scientific framework of thinking. Furthermore, the similarities, differences, and views of several pieces of literature that discussed related issues were evaluated in this review. Review: Regional anesthesia subarachnoid blockade (RASAB) or spinal anesthesia, is a procedure, which involves the administration of local anesthetic drugs into the subarachnoid space. Furthermore, the process is carried out between the lumbar (L) vertebrae L2-L3, L3-L4, or L4-L5. Spinal anesthesia is often used in surgical procedures involving the lower abdomen, pelvis, perineum, and lower extremities. Summary: In the setting of scoliosis, spinal anesthesia is challenging, but is not an absolute contraindication. Patients with scoliosis have unique characteristics, hence, anesthetists need to understand the impact of the disease on the body.","PeriodicalId":117902,"journal":{"name":"Indonesian Journal of Anesthesiology and Reanimation","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133420049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blood Transfusion Practices at The Intensive Observation Unit (Ruang Observasi Intensif/ROI) of Dr. Soetomo General Academic Hospital Surabaya 泗水Soetomo博士综合学术医院重症监护室(Ruang Observasi Intensif/ROI)的输血实践
Pub Date : 2023-01-20 DOI: 10.20473/ijar.v5i12023.1-10
Almira Saskia Sabila, Maulydia, Betty Agustina Tambunan, Edward Kusuma
Introduction: Blood transfusion is the process of transferring blood or its components, such as red blood cells, plasma, and platelets, from donor to recipient. The major reason for blood transfusion is anemia and bleeding, frequently seen in critically ill trauma patients in Intensive Observation Unit (Ruang Observasi Intensif/ROI). One of the most prevalent causes of potentially preventable death in trauma patients is uncontrolled bleeding. In addition to controlling the bleeding by surgical or interventional procedures, blood transfusion is carried out to maintain oxygenation to tissue, preventing organ dysfunction due to hypoxia. Objective: This study aimed to determine the profile of blood transfusion carried out on the patients in the ROI of Dr. Soetomo General Academic Hospital. Materials and Methods: This retrospective descriptive study was conducted using medical records involving 258 patients who met the inclusion criteria. Results: The result showed that the majority of patients were female, aged 26-35 years, had blood type O, and Rhesus (Rh)-positive, accounting for 55.04%, 26.36%, 39.53%, and 100%, respectively. The most common indication for transfusion was anemia, with a percentage of 69.10%, particularly severe anemia, accounting for 48.45%. Furthermore, 57.36% of patients were from the surgery department, and 36.05% stayed in ROI for 2-3 days. The most common blood component and unit transfused was packed red blood cells (PRC), with a percentage of 57.50% and 439 units at 47.82%. Most of the transfusions, with a percentage of 37.80%, were carried out within 3-4 hours. Some patients were experiencing pruritus, febrile, urticaria, and chills, accounting for 0.39%, 0.39%, 0.39%, and 0.39%, respectively. Conclusion: Understanding transfusion practices, including blood type distribution, can prevent blood shortage, estimate the need for blood among ROI patients in Dr. Soetomo General Academic Hospital, and further ensure that all transfusions are ABO and Rh compatible.
输血是将血液或其成分,如红细胞、血浆和血小板,从供体转移到受体的过程。输血的主要原因是贫血和出血,常见于重症监护病房(Ruang Observasi Intensif/ROI)的重症创伤患者。创伤患者潜在可预防死亡的最普遍原因之一是不受控制的出血。除了通过外科手术或介入手术控制出血外,还进行输血以维持组织的氧合,防止因缺氧而导致器官功能障碍。目的:本研究旨在了解苏托莫博士综合学术医院ROI患者的输血情况。材料和方法:本回顾性描述性研究使用258例符合纳入标准的患者的医疗记录。结果:患者以女性为主,年龄26 ~ 35岁,O型血和Rh阳性,分别占55.04%、26.36%、39.53%和100%。输血指征最多的是贫血,占69.10%,尤其是重度贫血,占48.45%。57.36%的患者来自外科,36.05%的患者在ROI停留2-3天。输血最多的血液成分和单位是填充红细胞(PRC),占57.50%,439个单位占47.82%。绝大多数输血发生在3 ~ 4小时内,占37.80%。部分患者出现瘙痒、发热、荨麻疹和寒战,分别占0.39%、0.39%、0.39%和0.39%。结论:了解输血操作,包括血型分布,可以预防血液短缺,估计Dr. Soetomo综合学术医院ROI患者的血液需求,并进一步确保所有输血都是ABO和Rh相容的。
{"title":"Blood Transfusion Practices at The Intensive Observation Unit (Ruang Observasi Intensif/ROI) of Dr. Soetomo General Academic Hospital Surabaya","authors":"Almira Saskia Sabila, Maulydia, Betty Agustina Tambunan, Edward Kusuma","doi":"10.20473/ijar.v5i12023.1-10","DOIUrl":"https://doi.org/10.20473/ijar.v5i12023.1-10","url":null,"abstract":"Introduction: Blood transfusion is the process of transferring blood or its components, such as red blood cells, plasma, and platelets, from donor to recipient. The major reason for blood transfusion is anemia and bleeding, frequently seen in critically ill trauma patients in Intensive Observation Unit (Ruang Observasi Intensif/ROI). One of the most prevalent causes of potentially preventable death in trauma patients is uncontrolled bleeding. In addition to controlling the bleeding by surgical or interventional procedures, blood transfusion is carried out to maintain oxygenation to tissue, preventing organ dysfunction due to hypoxia. Objective: This study aimed to determine the profile of blood transfusion carried out on the patients in the ROI of Dr. Soetomo General Academic Hospital. Materials and Methods: This retrospective descriptive study was conducted using medical records involving 258 patients who met the inclusion criteria. Results: The result showed that the majority of patients were female, aged 26-35 years, had blood type O, and Rhesus (Rh)-positive, accounting for 55.04%, 26.36%, 39.53%, and 100%, respectively. The most common indication for transfusion was anemia, with a percentage of 69.10%, particularly severe anemia, accounting for 48.45%. Furthermore, 57.36% of patients were from the surgery department, and 36.05% stayed in ROI for 2-3 days. The most common blood component and unit transfused was packed red blood cells (PRC), with a percentage of 57.50% and 439 units at 47.82%. Most of the transfusions, with a percentage of 37.80%, were carried out within 3-4 hours. Some patients were experiencing pruritus, febrile, urticaria, and chills, accounting for 0.39%, 0.39%, 0.39%, and 0.39%, respectively. Conclusion: Understanding transfusion practices, including blood type distribution, can prevent blood shortage, estimate the need for blood among ROI patients in Dr. Soetomo General Academic Hospital, and further ensure that all transfusions are ABO and Rh compatible.","PeriodicalId":117902,"journal":{"name":"Indonesian Journal of Anesthesiology and Reanimation","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123069165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric Shock Profile in The Pediatric Intensive Care Unit (PICU) of Dr. Soetomo General Academic Hospital Soetomo博士综合学术医院儿科重症监护病房(PICU)的儿科休克概况
Pub Date : 2023-01-20 DOI: 10.20473/ijar.v5i12023.11-17
Rafida Anshori, A. Setyaningtyas, Arie Utariani, N. P. Kusumastuti
Introduction: Shock is a life-threatening condition caused by circulatory failure which increases morbidity and mortality rate. According to the western literature, about 2% of children are admitted to hospitals worldwide due to shock. Objective: This study aimed to describe the pediatric shock profile of patients in the Pediatric Intensive Care Unit (PICU) of Dr. Soetomo General Academic Hospital between 1 January to 1 December 2019. Materials and Methods: A total of 60 patients were selected as the participants using a descriptive method. Data collection was carried out by recording the exact time the participants first entered the PICU. Furthermore, data were collected based on gender, age, physical and laboratory examination, diagnosis of shock, patients’ outcomes, as well as PRISM III score. Results: The results of this study that the males and children are 51.7% and 53.3%, respectively. At an infant age, the distribution of the highest average pulse and breathing frequency was 135 and 32.2, respectively. The highest average body temperature at the age of adolescents was 37.19°C. Furthermore, the patients' diagnoses were dominated by distributive shock with the highest PRISM III score ≥8 and deaths recorded of 76.6%, 60%, and 61.7%, respectively. The diagnosis results showed that distributive shock leads to the highest mortality with a PRISM III score of 51.7% and 53.3%. Conclusion: Distributive shock contributes to the patient's diagnoses and mortality rate with the highest score of PRISM III being ≥8. From this conclusion, the PICU needs to be more responsive to detect distributive shock in children.
休克是一种由循环衰竭引起的危及生命的疾病,它增加了发病率和死亡率。根据西方文献,全世界约有2%的儿童因休克而入院。目的:本研究旨在描述2019年1月1日至12月1日期间Dr. Soetomo综合学术医院儿科重症监护病房(PICU)患者的儿科休克情况。材料与方法:采用描述性方法,共选取60例患者作为研究对象。数据收集是通过记录参与者首次进入PICU的确切时间来进行的。此外,根据性别、年龄、体格和实验室检查、休克诊断、患者结局以及PRISM III评分收集数据。结果:本研究结果男性占51.7%,儿童占53.3%。在婴儿时期,最高平均脉搏和呼吸频率的分布分别为135次和32.2次。青少年最高平均体温为37.19℃。此外,患者的诊断以分布性休克为主,PRISM III评分≥8分最高,死亡率分别为76.6%、60%和61.7%。诊断结果显示,分布性休克导致的死亡率最高,PRISM III评分分别为51.7%和53.3%。结论:分布性休克有助于患者的诊断和死亡率,PRISMⅲ评分最高≥8分。从这个结论来看,PICU需要更灵敏地发现儿童的分布性休克。
{"title":"Pediatric Shock Profile in The Pediatric Intensive Care Unit (PICU) of Dr. Soetomo General Academic Hospital","authors":"Rafida Anshori, A. Setyaningtyas, Arie Utariani, N. P. Kusumastuti","doi":"10.20473/ijar.v5i12023.11-17","DOIUrl":"https://doi.org/10.20473/ijar.v5i12023.11-17","url":null,"abstract":"Introduction: Shock is a life-threatening condition caused by circulatory failure which increases morbidity and mortality rate. According to the western literature, about 2% of children are admitted to hospitals worldwide due to shock. Objective: This study aimed to describe the pediatric shock profile of patients in the Pediatric Intensive Care Unit (PICU) of Dr. Soetomo General Academic Hospital between 1 January to 1 December 2019. Materials and Methods: A total of 60 patients were selected as the participants using a descriptive method. Data collection was carried out by recording the exact time the participants first entered the PICU. Furthermore, data were collected based on gender, age, physical and laboratory examination, diagnosis of shock, patients’ outcomes, as well as PRISM III score. Results: The results of this study that the males and children are 51.7% and 53.3%, respectively. At an infant age, the distribution of the highest average pulse and breathing frequency was 135 and 32.2, respectively. The highest average body temperature at the age of adolescents was 37.19°C. Furthermore, the patients' diagnoses were dominated by distributive shock with the highest PRISM III score ≥8 and deaths recorded of 76.6%, 60%, and 61.7%, respectively. The diagnosis results showed that distributive shock leads to the highest mortality with a PRISM III score of 51.7% and 53.3%. Conclusion: Distributive shock contributes to the patient's diagnoses and mortality rate with the highest score of PRISM III being ≥8. From this conclusion, the PICU needs to be more responsive to detect distributive shock in children.","PeriodicalId":117902,"journal":{"name":"Indonesian Journal of Anesthesiology and Reanimation","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130959935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using Multimodal Analgesia for Breakthrough Pain in Stage IV Breast Cancer Patient 多模式镇痛治疗IV期乳腺癌突破性疼痛
Pub Date : 2023-01-20 DOI: 10.20473/ijar.v5i12023.37-44
I. Wijaya, Mahmud
Introduction: Breakthrough Pain (BTP) is experienced as mild to moderate-severe pain, from only a few seconds to hours. It causes a decrease in the quality of life and functional capacities. Furthermore, BPT must be recognizable, assessed, and controlled to prevent its relapse and severity. Case report: A woman, 45 years old, having breast cancer along with pulmonary, femur, and cervical metastases, came with the main complaint of pain. The patient had a pain score of NRS 9, which was felt intermittently for the last 3 months. Treatment has been carried out with MST 10 mg/8 hours and a Durogesic® patch (fentanyl 50 mcg/h) but the pain did not subside. Moreover, the patient was unable to identify any precipitating factors or pain relievers, while the diagnosis confirmed BTP. The rescue dose was administered in a range of 10 – 20% of the total daily dose in the last 24 hours equivalent to 11 – 22 mg intravenous Morphine or equianalgesic with 110 – 220 mcg of fentanyl. For immediate effect, transmucosal fentanyl was recommended, but this preparation is currently unavailable. Moreover, therapy was carried out with the continuous administration of Morphine, and the pain reduced to NRS 0 – 3 on the second day. Conclusion: Transmucosal fentanyl, either buccal, sublingual, oral, or nasal mucosa, was proven to be effective in treating BTP. However, when transmucosal fentanyl is not available, multimodal analgesia is an effective alternative.
突破性疼痛(BTP)是一种轻度到中度至重度的疼痛,持续时间从几秒钟到几小时不等。它会导致生活质量和功能的下降。此外,BPT必须被识别、评估和控制,以防止复发和严重程度。病例报告:一名女性,45岁,乳腺癌合并肺、股骨和宫颈转移,以疼痛为主要主诉。患者疼痛评分为NRS 9,过去3个月间歇性疼痛。使用MST 10mg /8小时和Durogesic®贴片(芬太尼50mcg /h)进行治疗,但疼痛没有减轻。此外,患者无法识别任何诱发因素或止痛药,而诊断证实BTP。抢救剂量为最后24小时每日总剂量的10 - 20%,相当于静脉注射吗啡11 - 22毫克或与芬太尼等镇痛110 - 220微克。为了获得即时效果,建议使用经黏膜芬太尼,但目前尚无这种制剂。继续给予吗啡治疗,第2天疼痛减轻至NRS 0 ~ 3。结论:经粘膜芬太尼,无论是口腔、舌下、口腔或鼻粘膜,都被证明是治疗BTP的有效方法。然而,当经黏膜芬太尼不可用时,多模式镇痛是一种有效的替代方法。
{"title":"Using Multimodal Analgesia for Breakthrough Pain in Stage IV Breast Cancer Patient","authors":"I. Wijaya, Mahmud","doi":"10.20473/ijar.v5i12023.37-44","DOIUrl":"https://doi.org/10.20473/ijar.v5i12023.37-44","url":null,"abstract":"Introduction: Breakthrough Pain (BTP) is experienced as mild to moderate-severe pain, from only a few seconds to hours. It causes a decrease in the quality of life and functional capacities. Furthermore, BPT must be recognizable, assessed, and controlled to prevent its relapse and severity. Case report: A woman, 45 years old, having breast cancer along with pulmonary, femur, and cervical metastases, came with the main complaint of pain. The patient had a pain score of NRS 9, which was felt intermittently for the last 3 months. Treatment has been carried out with MST 10 mg/8 hours and a Durogesic® patch (fentanyl 50 mcg/h) but the pain did not subside. Moreover, the patient was unable to identify any precipitating factors or pain relievers, while the diagnosis confirmed BTP. The rescue dose was administered in a range of 10 – 20% of the total daily dose in the last 24 hours equivalent to 11 – 22 mg intravenous Morphine or equianalgesic with 110 – 220 mcg of fentanyl. For immediate effect, transmucosal fentanyl was recommended, but this preparation is currently unavailable. Moreover, therapy was carried out with the continuous administration of Morphine, and the pain reduced to NRS 0 – 3 on the second day. Conclusion: Transmucosal fentanyl, either buccal, sublingual, oral, or nasal mucosa, was proven to be effective in treating BTP. However, when transmucosal fentanyl is not available, multimodal analgesia is an effective alternative.","PeriodicalId":117902,"journal":{"name":"Indonesian Journal of Anesthesiology and Reanimation","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134583406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Indonesian Journal of Anesthesiology and Reanimation
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