Pub Date : 2019-09-01DOI: 10.33945/sami/ecc.2019.5.1
M. Rahimi, S. Jamehbozorgi, H. Chermette, R. Ghiasi, M. Kalhor
In this study, the substituent effect on the electronic, spectroscopic properties and thermodynamic parameters of neutral and oxidized states of ferrocylidene acetophenone complexes was investigated by adopting the hybrid meta exchange-correlation functional of M06-2X. The frontier orbitals and the highest occupied molecular orbitals–lowest unoccupied molecular orbitals gaps of the substituted compounds were determined. Ionization potential (IP), electron affinity, and reorganization energy values of these molecules were estimated. The thermodynamic parameters (free energy and enthalpy) of the oxidation reaction of the studied complexes were calculated. Also, a variation on the wavenumber of carbonyl group in both states was revealed. Correlations between the evaluated properties and Hammett's constant were explored.
{"title":"Computational study of substituent effect on the electronic properties of ferrocylidene acetophenones complexes","authors":"M. Rahimi, S. Jamehbozorgi, H. Chermette, R. Ghiasi, M. Kalhor","doi":"10.33945/sami/ecc.2019.5.1","DOIUrl":"https://doi.org/10.33945/sami/ecc.2019.5.1","url":null,"abstract":"In this study, the substituent effect on the electronic, spectroscopic properties and thermodynamic parameters of neutral and oxidized states of ferrocylidene acetophenone complexes was investigated by adopting the hybrid meta exchange-correlation functional of M06-2X. The frontier orbitals and the highest occupied molecular orbitals–lowest unoccupied molecular orbitals gaps of the substituted compounds were determined. Ionization potential (IP), electron affinity, and reorganization energy values of these molecules were estimated. The thermodynamic parameters (free energy and enthalpy) of the oxidation reaction of the studied complexes were calculated. Also, a variation on the wavenumber of carbonyl group in both states was revealed. Correlations between the evaluated properties and Hammett's constant were explored.","PeriodicalId":11871,"journal":{"name":"Eurasian Chemical Communications","volume":"78 3 Pt 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91033140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.33945/sami/ecc.2019.5.8
Ehsan Fereydoun Asl, Fatemeh S. Mohseni‐Shahri, F. Moeinpour
In this study, NiFe 2 O 4 magnetic nanoparticles as an adsorbent for lead (Pb) removal were coated on sand particles. Adsorption studies were conducted to investigate the efficacy of contact time, pH, adsorbent dosage and initial lead ion concentration on the removal efficiency. To choose the most fitting kinetic model, the pseudo-first order and pseudo-second order models were compared and the most suitable kinetic model was selected by the pseudo-second order. Langmuir and Freundlich isotherms were evaluated and the most suitable isotherm was observed as the Freundlich model. In addition, the NiFe2O4 coated sand can simply be removed by an ordinary filtration process.
{"title":"NiFe2O4 coated sand as a nano-adsorbent for removal of Pb (II) from aqueous solutions","authors":"Ehsan Fereydoun Asl, Fatemeh S. Mohseni‐Shahri, F. Moeinpour","doi":"10.33945/sami/ecc.2019.5.8","DOIUrl":"https://doi.org/10.33945/sami/ecc.2019.5.8","url":null,"abstract":"In this study, NiFe 2 O 4 magnetic nanoparticles as an adsorbent for lead (Pb) removal were coated on sand particles. Adsorption studies were conducted to investigate the efficacy of contact time, pH, adsorbent dosage and initial lead ion concentration on the removal efficiency. To choose the most fitting kinetic model, the pseudo-first order and pseudo-second order models were compared and the most suitable kinetic model was selected by the pseudo-second order. Langmuir and Freundlich isotherms were evaluated and the most suitable isotherm was observed as the Freundlich model. In addition, the NiFe2O4 coated sand can simply be removed by an ordinary filtration process.","PeriodicalId":11871,"journal":{"name":"Eurasian Chemical Communications","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83665684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.33945/sami/ecc.2019.5.4
M. Khodaie, N. Ghasemi, M. Ramezani
Biological synthesis of metallic nanoparticles is considered as a fast, eco-friendly, affordable and easily scalable technology. Also, the nanoparticles produced by plants are very stable. In this study, the focus is on the synthesis of silver nanoparticles using extract of eryngium campestre. The effective parameters such as concentration of silver nitrate, pH, temperature and time, size and morphology of the nanoparticles were investigated and controlled by (UV-Vis) spectroscopy in the range of 300-500 nm. Silver nanoparticles were synthesized under optimal conditions of 1 mM silver nitrate, pH=5, temperature= 50 °C and synthesis time of 100 minutes. Then, characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), Scanning electron microscope (SEM), Energy dispersive X-ray (EDX) analysis.
{"title":"Green synthesis of silver nanoparticles using (Eryngium Campestre) leaf extract","authors":"M. Khodaie, N. Ghasemi, M. Ramezani","doi":"10.33945/sami/ecc.2019.5.4","DOIUrl":"https://doi.org/10.33945/sami/ecc.2019.5.4","url":null,"abstract":"Biological synthesis of metallic nanoparticles is considered as a fast, eco-friendly, affordable and easily scalable technology. Also, the nanoparticles produced by plants are very stable. In this study, the focus is on the synthesis of silver nanoparticles using extract of eryngium campestre. The effective parameters such as concentration of silver nitrate, pH, temperature and time, size and morphology of the nanoparticles were investigated and controlled by (UV-Vis) spectroscopy in the range of 300-500 nm. Silver nanoparticles were synthesized under optimal conditions of 1 mM silver nitrate, pH=5, temperature= 50 °C and synthesis time of 100 minutes. Then, characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), Scanning electron microscope (SEM), Energy dispersive X-ray (EDX) analysis.","PeriodicalId":11871,"journal":{"name":"Eurasian Chemical Communications","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81121943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.33945/sami/ecc.2019.5.6
H. Shafiekhani, F. Mostaghni, N. Rad
A simple approach based on cyclic voltammetry (CV) was developed for the simultaneous determination of dopamine (DA) and uric acid (UA) in the presence of ascorbic acid (AA) using a modified glassy carbon paste electrode (GCPE). In the present study, analytical parameters were optimized and electrochemical performance of modified electrode was investigated. The calibration curves were obtained over the range of 15.97-157.98 μmol L-1 dopamine and 15.97-195.35 μmol L-1 uric acid. Detection limits of 12.38 μmol L-1 dopamine and 3 μmol L-1 uric acid were also obtained at pH 7.0. The modified electrode was used for practical application for the detection of dopamine and uric acid in the real samples of uric acid and dopamine injection, human serum and urine samples.
{"title":"Simultaneous determination of dopamine and uric acid using a glassy carbon paste electrode modified with copper- para red complex","authors":"H. Shafiekhani, F. Mostaghni, N. Rad","doi":"10.33945/sami/ecc.2019.5.6","DOIUrl":"https://doi.org/10.33945/sami/ecc.2019.5.6","url":null,"abstract":"A simple approach based on cyclic voltammetry (CV) was developed for the simultaneous determination of dopamine (DA) and uric acid (UA) in the presence of ascorbic acid (AA) using a modified glassy carbon paste electrode (GCPE). In the present study, analytical parameters were optimized and electrochemical performance of modified electrode was investigated. The calibration curves were obtained over the range of 15.97-157.98 μmol L-1 dopamine and 15.97-195.35 μmol L-1 uric acid. Detection limits of 12.38 μmol L-1 dopamine and 3 μmol L-1 uric acid were also obtained at pH 7.0. The modified electrode was used for practical application for the detection of dopamine and uric acid in the real samples of uric acid and dopamine injection, human serum and urine samples.","PeriodicalId":11871,"journal":{"name":"Eurasian Chemical Communications","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87161652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.33945/sami/ecc.2019.5.2
Mostafa Khaledi, Hoda Ziyaee Qychan Atiq, N. Chamkouri, A. Mojaddami
In this study, physicochemical properties of 49 compounds extracted from anti-inflammatory sponge species with the aim of ADMET test and Lipinski rule of five have been determined. Fourteen compounds, which showed best results, were subjected to molecular docking studies with IL-17. Among these compounds, Four compounds with low binding energy were obtained. These compounds, namely, frondosins C, frondosins D, methylpourewate B and Cadlinolide C have shown promising ADMET properties and strong interactions in the active site of IL-17. The ROC curve with the acceptable area under the curve of 0.853 was used for validation of the docking protocol. If the efficacy of these compounds is proven by biochemical tests, these molecules will be potentially important inhibitors of IL-17A and used as basis for the further development of anti-inflammatory and anti-psoriasis agents.
{"title":"Molecular docking and druggability studies of terpenoid-derived metabolites from marine sponges as IL-17A inhibitors","authors":"Mostafa Khaledi, Hoda Ziyaee Qychan Atiq, N. Chamkouri, A. Mojaddami","doi":"10.33945/sami/ecc.2019.5.2","DOIUrl":"https://doi.org/10.33945/sami/ecc.2019.5.2","url":null,"abstract":"In this study, physicochemical properties of 49 compounds extracted from anti-inflammatory sponge species with the aim of ADMET test and Lipinski rule of five have been determined. Fourteen compounds, which showed best results, were subjected to molecular docking studies with IL-17. Among these compounds, Four compounds with low binding energy were obtained. These compounds, namely, frondosins C, frondosins D, methylpourewate B and Cadlinolide C have shown promising ADMET properties and strong interactions in the active site of IL-17. The ROC curve with the acceptable area under the curve of 0.853 was used for validation of the docking protocol. If the efficacy of these compounds is proven by biochemical tests, these molecules will be potentially important inhibitors of IL-17A and used as basis for the further development of anti-inflammatory and anti-psoriasis agents.","PeriodicalId":11871,"journal":{"name":"Eurasian Chemical Communications","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81877987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.33945/sami/ecc.2019.5.5
Somayeh, Adibi, Sedeh, Mohammad, Kazem, Mohammadi, Masood, Fereidoonnezhad, A. Javid
In this paper, we present the convenient syntheses of some new phenyl hydrazin derivatives 8 (a-h). For this purpose, condensation of thiosemicarbazide and acenaphtylene -9,10-quinone was performed to form acenaphtho[1,2-e]-1,2,4-triazine-9(8H)-thiones . Afterwards, the subsequent reaction with benzyl chloride derivatives was subjected to hydrazine and, then, the reaction was proceeded with different benzaldehyde derivatives to achieve 9-(phenyl imino hydrazin)-acenaphtho[1,2-e]-1,2,4-triazine derivatives (8a-h) in good yield. The cytotoxicity of the synthesized compounds was also studied against human cancer cell lines including breast (MCF-7), ovarian (SKOV3) and lung (A549) cell lines. Among them 8b, 8c and 8h showed moderate to good activity.
{"title":"Synthesis and anticancer evaluation of novel acenaphtho [1,2-e]-1,2,4- triazine derivatives","authors":"Somayeh, Adibi, Sedeh, Mohammad, Kazem, Mohammadi, Masood, Fereidoonnezhad, A. Javid","doi":"10.33945/sami/ecc.2019.5.5","DOIUrl":"https://doi.org/10.33945/sami/ecc.2019.5.5","url":null,"abstract":"In this paper, we present the convenient syntheses of some new phenyl hydrazin derivatives 8 (a-h). For this purpose, condensation of thiosemicarbazide and acenaphtylene -9,10-quinone was performed to form acenaphtho[1,2-e]-1,2,4-triazine-9(8H)-thiones . Afterwards, the subsequent reaction with benzyl chloride derivatives was subjected to hydrazine and, then, the reaction was proceeded with different benzaldehyde derivatives to achieve 9-(phenyl imino hydrazin)-acenaphtho[1,2-e]-1,2,4-triazine derivatives (8a-h) in good yield. The cytotoxicity of the synthesized compounds was also studied against human cancer cell lines including breast (MCF-7), ovarian (SKOV3) and lung (A549) cell lines. Among them 8b, 8c and 8h showed moderate to good activity.","PeriodicalId":11871,"journal":{"name":"Eurasian Chemical Communications","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84674363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.33945/sami/ecc.2019.5.7
S. Shariati, Elnaz Shahpanah, A. Bolouri, N. Hashemifard, F. Shariati
In the present study, polystyrene nanofibers (PS NFs) were synthesized by electrospinning method and used as adsorbents in solid phase extraction of phenol from aqueous solutions. Phenol was reacted with 4-aminoantipyrine (4-AAP) reagent in presence of potassium hexacyanoferrate (III). The coloured product was extracted by solid phase extraction using electrospun synthesized polystyrene nanofibers and determined by UV-Vis spectrophotometer. At certain conditions of electrospinning process, the variables affecting the solid phase extraction efficiency were studied and optimized. Under the optimized conditions, (sorbent mass: 0.025 g PS NF, sample flow rate: 2.5 mL min−1, eluent: acetone: NaOH 0.1 M (1:1 v/v)), the linear dynamic range (LDR) and limit of detection (LOD as 3 Sb/m) for extraction of phenol from 50 mL of aqueous solutions were determined as 15-2500 µg L-1 and 10 µg L-1, respectively. The precision (as RSD %) of the extraction method using the proposed adsorbent was lower than 7.6%. Finally, the applicability of the proposed method for the extraction of phenol from industrial aqueous samples was examined and satisfactory results were obtained.
采用静电纺丝法合成了聚苯乙烯纳米纤维，并将其作为固相萃取苯酚的吸附剂。在六氰高铁酸钾(III)存在下，苯酚与4-氨基安提比林(4-AAP)试剂反应，采用静电纺合成聚苯乙烯纳米纤维固相萃取法提取有色产物，紫外可见分光光度计测定。在一定的静电纺丝工艺条件下，对影响固相萃取效率的因素进行了研究和优化。在最佳条件下(吸附剂质量:0.025 g PS - NF，样品流速:2.5 mL min -1，洗脱液:丙酮:NaOH 0.1 M (1:1 v/v))，从50 mL水溶液中提取苯酚的线性动态范围(LDR)为15 ~ 2500µg L-1，检出限(LOD为3 Sb/ M)为10µg L-1。该吸附剂提取方法的精密度(RSD %)小于7.6%。最后，对该方法在工业水样中苯酚提取中的适用性进行了验证，取得了满意的结果。
{"title":"Electrospun polystyrene nanofiber adsorbent for solid phase extraction of phenol as its quinoid derivative from aqueous solutions","authors":"S. Shariati, Elnaz Shahpanah, A. Bolouri, N. Hashemifard, F. Shariati","doi":"10.33945/sami/ecc.2019.5.7","DOIUrl":"https://doi.org/10.33945/sami/ecc.2019.5.7","url":null,"abstract":"In the present study, polystyrene nanofibers (PS NFs) were synthesized by electrospinning method and used as adsorbents in solid phase extraction of phenol from aqueous solutions. Phenol was reacted with 4-aminoantipyrine (4-AAP) reagent in presence of potassium hexacyanoferrate (III). The coloured product was extracted by solid phase extraction using electrospun synthesized polystyrene nanofibers and determined by UV-Vis spectrophotometer. At certain conditions of electrospinning process, the variables affecting the solid phase extraction efficiency were studied and optimized. Under the optimized conditions, (sorbent mass: 0.025 g PS NF, sample flow rate: 2.5 mL min−1, eluent: acetone: NaOH 0.1 M (1:1 v/v)), the linear dynamic range (LDR) and limit of detection (LOD as 3 Sb/m) for extraction of phenol from 50 mL of aqueous solutions were determined as 15-2500 µg L-1 and 10 µg L-1, respectively. The precision (as RSD %) of the extraction method using the proposed adsorbent was lower than 7.6%. Finally, the applicability of the proposed method for the extraction of phenol from industrial aqueous samples was examined and satisfactory results were obtained.","PeriodicalId":11871,"journal":{"name":"Eurasian Chemical Communications","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75223004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.33945/sami/ecc.2019.5.3
E. Mehdipour, E. Baharlouei, Z. Zarnegar
Trimethylsilylation of alcohols and phenols were carried out under solvent-free conditions with hexamethyldisilazane (HMDS) using LaCoO3 perovskite. LaCoO3 as an efficient catalyst accelerated this reaction under milder condition. The advantages of this method are evident regarding, easy separation, low cost and low catalyst loading, lack of pollution, easy work-up, and selective protection of primary and secondary alcohols.
{"title":"Selective trimethylsilylation of alcohols and phenols with hexamethyldisilazane catalyzed by LaCoO3 perovskite","authors":"E. Mehdipour, E. Baharlouei, Z. Zarnegar","doi":"10.33945/sami/ecc.2019.5.3","DOIUrl":"https://doi.org/10.33945/sami/ecc.2019.5.3","url":null,"abstract":"Trimethylsilylation of alcohols and phenols were carried out under solvent-free conditions with hexamethyldisilazane (HMDS) using LaCoO3 perovskite. LaCoO3 as an efficient catalyst accelerated this reaction under milder condition. The advantages of this method are evident regarding, easy separation, low cost and low catalyst loading, lack of pollution, easy work-up, and selective protection of primary and secondary alcohols.","PeriodicalId":11871,"journal":{"name":"Eurasian Chemical Communications","volume":"103 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78747425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-01DOI: 10.33945/sami/ecc.2019.2.7
S. Sajjadifar, I. Amini, H. Jabbari, Omidali Pouralimardan, M. Fekri, K. Pal
1-Methyl-3-(2-oxyethyl)-1H-Imidazol-3-ium-Borate Sulfonic Acid ([MOEI]-BSA) was easily prepared and used as a new and highly efficient solid acid catalyst for the synthesis of benzimidazole derivatives with high isolated yields. Various substituted benzimidazoles were synthesized by a combination of o-phenylenediamines and aldehydes in the presence of [MOEI]-BSA with excellent yields in water and under a mild and green reaction conditions. This method is also applicable for precursors such as aromatic and unsaturated aldehydes and o-phenylenediamines. Addition of organic part to BSA and synthesis of [MOEI]-BSA as a new Bronsted acidic ionic liquid (BAIL) improved the efficiency of this catalyst. 1-Methyl-3-(2-oxyethyl)-1H-Imidazol-3-ium-Borate Sulfonic Acid ([MOEI]-BSA) was easily prepared and used as a new and highly efficient solid acid catalyst for the synthesis of benzimidazole derivatives with high isolated yields. Various substituted benzimidazoles were synthesized by a combination of o-phenylenediamines and aldehydes in the presence of [MOEI]-BSA with excellent yields in water and under a mild and green reaction conditions. This method is also applicable for precursors such as aromatic and unsaturated aldehydes and o-phenylenediamines. Addition of organic part to BSA and synthesis of [MOEI]-BSA as a new Bronsted acidic ionic liquid (BAIL) improved the efficiency of this catalyst.
{"title":"An efficient facile and one-pot synthesis of 2-arylsubstituted benzimidazole derivatives using 1-methyl-3-(2-oxyethyl)-1H-imidazol-3-ium-borate sulfonic acid as a recyclable and highly efficient ionic liquid catalyst at green condition","authors":"S. Sajjadifar, I. Amini, H. Jabbari, Omidali Pouralimardan, M. Fekri, K. Pal","doi":"10.33945/sami/ecc.2019.2.7","DOIUrl":"https://doi.org/10.33945/sami/ecc.2019.2.7","url":null,"abstract":"1-Methyl-3-(2-oxyethyl)-1H-Imidazol-3-ium-Borate Sulfonic Acid ([MOEI]-BSA) was easily prepared and used as a new and highly efficient solid acid catalyst for the synthesis of benzimidazole derivatives with high isolated yields. Various substituted benzimidazoles were synthesized by a combination of o-phenylenediamines and aldehydes in the presence of [MOEI]-BSA with excellent yields in water and under a mild and green reaction conditions. This method is also applicable for precursors such as aromatic and unsaturated aldehydes and o-phenylenediamines. Addition of organic part to BSA and synthesis of [MOEI]-BSA as a new Bronsted acidic ionic liquid (BAIL) improved the efficiency of this catalyst. 1-Methyl-3-(2-oxyethyl)-1H-Imidazol-3-ium-Borate Sulfonic Acid ([MOEI]-BSA) was easily prepared and used as a new and highly efficient solid acid catalyst for the synthesis of benzimidazole derivatives with high isolated yields. Various substituted benzimidazoles were synthesized by a combination of o-phenylenediamines and aldehydes in the presence of [MOEI]-BSA with excellent yields in water and under a mild and green reaction conditions. This method is also applicable for precursors such as aromatic and unsaturated aldehydes and o-phenylenediamines. Addition of organic part to BSA and synthesis of [MOEI]-BSA as a new Bronsted acidic ionic liquid (BAIL) improved the efficiency of this catalyst.","PeriodicalId":11871,"journal":{"name":"Eurasian Chemical Communications","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88777434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.33945/sami/ecc.2019.6.2
S. Hayati, R. Yazdani, S. Fallahi, Zivar Atashbar, Seyed, Ashkan Tabibzadeh Dezfuli
The present research aimed at comparing the effectiveness of promethazine and diazepam in patients suffering from acute peripheral vertigo. This is a double blind clinical trial with a sample of 154 patients visiting the emergency section of Shahid Mohammadi Hospital in Bandar Abbas in 2017-18. The participants were randomly divided into two groups of 77, one treated with intravenous promethazine (50 mg) and the other with intravenous Diazepam (10 mg). The severity of vertigo was measured qualitatively and quantitatively 20 minutes later in both groups. Participants were 46 (29.9%) male and 108 (70.1%) female visiting the emergency section of hospital. The mean score of vertigo severity in Promethazine group was 44.44±17.94 and that of Diazepam group was 2.49±+3.87. The severity scores before and after the treatment in promethazine group were respectively 7.75±1.59 and 2.72±1.93. The mean scores of vertigo severity before and after the treatment in promethazine group was -5.04+2.10 and in the diazepam group it was -3.83+3.09. The intergroup difference was statistically significant (p=.013). The results revealed that intravenous promethazine and diazepam applied 20 minutes after prescription are both effective in controlling the severity of vertigo. Considering the probability of occurrence of extrapyramidal side-effects it can be suggested that the infusion of this medication can be done slowly as it takes longer time. Meanwhile, vital signs should be precisely controlled.
{"title":"Intravenous promethazine vs. diazepam to reduce symptoms of peripheral vertigo in emergency section: a double blind clinical trial","authors":"S. Hayati, R. Yazdani, S. Fallahi, Zivar Atashbar, Seyed, Ashkan Tabibzadeh Dezfuli","doi":"10.33945/sami/ecc.2019.6.2","DOIUrl":"https://doi.org/10.33945/sami/ecc.2019.6.2","url":null,"abstract":"The present research aimed at comparing the effectiveness of promethazine and diazepam in patients suffering from acute peripheral vertigo. This is a double blind clinical trial with a sample of 154 patients visiting the emergency section of Shahid Mohammadi Hospital in Bandar Abbas in 2017-18. The participants were randomly divided into two groups of 77, one treated with intravenous promethazine (50 mg) and the other with intravenous Diazepam (10 mg). The severity of vertigo was measured qualitatively and quantitatively 20 minutes later in both groups. Participants were 46 (29.9%) male and 108 (70.1%) female visiting the emergency section of hospital. The mean score of vertigo severity in Promethazine group was 44.44±17.94 and that of Diazepam group was 2.49±+3.87. The severity scores before and after the treatment in promethazine group were respectively 7.75±1.59 and 2.72±1.93. The mean scores of vertigo severity before and after the treatment in promethazine group was -5.04+2.10 and in the diazepam group it was -3.83+3.09. The intergroup difference was statistically significant (p=.013). The results revealed that intravenous promethazine and diazepam applied 20 minutes after prescription are both effective in controlling the severity of vertigo. Considering the probability of occurrence of extrapyramidal side-effects it can be suggested that the infusion of this medication can be done slowly as it takes longer time. Meanwhile, vital signs should be precisely controlled.","PeriodicalId":11871,"journal":{"name":"Eurasian Chemical Communications","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83716317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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