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Exploration on correlation of high DLX2 expression with poor prognosis and cellular proliferation in epithelial ovarian cancers 上皮性卵巢癌DLX2高表达与不良预后及细胞增殖的相关性探讨
IF 0.4 4区 医学 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2021-06-15 DOI: 10.31083/J.EJGO.2021.03.2093
Menghui Huang, Yu-Wen Han, Qinghua Xi, Yunfeng Jin, Ying-lei Liu, Yunhe Han, Hai-Li Kai, Qian Zhang, Yan-Li Zheng
Objective: It has been found that overexpression of distal-less homeobox 2 (DLX2) is closely correlated with multiple cancers. However, the role of DLX2 in the pathogenesis of ovarian cancers is not known. This study was designed to explore the mechanism of action of DLX2 on cellular proliferation and apoptosis in epithelial ovarian cancers (EOCs). Methods: A total of 119 EOC tissue specimens were analyzed immunohistochemically, and the correlation between DLX2 expressional level and clinicopathological characteristics was determined. Moreover, western blot method was used to measure DLX2 protein in EOC specimen of different grades and EOC cell lines and explore its molecular mechanism of action. Kaplan-Meier survival analysis revealed that overexpression of DLX2 was obviously correlated with an adverse clinical outcome in EOCs (P < 0.01*). Results: DLX2 expressional level had an obvious association with histopathological grade, FIGO stage, ascites and ki-67 expressional level in EOC patients and DLX2 exerted a crucial effect in regulating cellular proliferation in EOCs. Knocking down DLX2 using shRNA-DLX2 reduced the proliferation and enhanced the apoptosis in EOC cells. Conclusion: DLX2 might act as a new prognostic indicator and have an important value for molecular targeted therapeutic drugs in EOCs.
目的:研究发现远端少同源盒2(DLX2)的过度表达与多种癌症密切相关。然而,DLX2在卵巢癌发病机制中的作用尚不清楚。本研究旨在探讨DLX2对卵巢上皮癌细胞增殖和凋亡的作用机制。方法:对119例EOC组织标本进行免疫组化分析,确定DLX2表达水平与临床病理特征的相关性。此外,采用蛋白质印迹法测定了不同级别EOC标本和EOC细胞系中DLX2蛋白的表达,并探讨了其作用的分子机制。Kaplan-Meier生存分析显示,DLX2的过度表达与EOC的不良临床结果明显相关(P<0.01)。使用shRNA-DLX2敲除DLX2降低了EOC细胞的增殖并增强了细胞凋亡。结论:DLX2可能是一种新的预后指标,对EOCs的分子靶向治疗药物具有重要价值。
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引用次数: 0
Bevacizumab for malignant pleural effusion in ovarian clear cell carcinoma: a case report 贝伐单抗治疗卵巢透明细胞癌恶性胸腔积液1例
IF 0.4 4区 医学 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2021-06-15 DOI: 10.31083/J.EJGO.2021.03.2338
Di Wu, Yanqin Zhang, Jinwei Miao
Objective: Malignant pleural effusion (MPE) is a major problem associated with late phase of epithelial ovarian cancer for which an optimum treatment consensus has yet to be determined. Although bevacizumab (Bev), a VEGF ligand inhibitor, has been shown to effectively control MPE, the clinical benefit of half-dose Bev treatment to control MPE remains unclear. Methods: We describe a patient with platinum-sensitive ovarian clear cell cancer (OCCC) and symptomatic MPE for whom tumor markers increased after one cycle of paclitaxel and carboplatin chemotherapy. After switching to five cycles of Bev plus paclitaxel/carboplatin chemotherapy, we observed the disappearance of MPE. Conclusion: The half-dose Bev therapy may be an effective treatment for MPE in OCCC. However, further investigation is still warranted to evaluate the therapeutic effectiveness of Bev.
目的:恶性胸腔积液(MPE)是与晚期上皮性卵巢癌相关的主要问题,其最佳治疗共识尚未确定。尽管VEGF配体抑制剂贝伐单抗(bevacizumab, Bev)已被证明能有效控制MPE,但半剂量Bev治疗控制MPE的临床益处尚不清楚。方法:我们描述了一个铂敏感卵巢透明细胞癌(OCCC)和症状性MPE患者,其肿瘤标志物在紫杉醇和卡铂化疗一个周期后升高。切换到5个周期的Bev +紫杉醇/卡铂化疗后,我们观察到MPE消失。结论:半剂量贝弗可能是治疗OCCC MPE的有效方法。然而,Bev的治疗效果仍有待进一步研究。
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引用次数: 1
BRCA-guided therapy of ovarian cancer BRCA引导下治疗癌症
IF 0.4 4区 医学 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2021-06-15 DOI: 10.31083/J.EJGO.2021.03.2210
P. Economopoulou, I. Kotsantis, A. Bamias
Advanced (FIGO stages III and IV) epithelial ovarian cancer (aEOC) accounts for the majority of deaths from gynecological cancers in western countries. Although the prognosis of this disease has been considerably improved in the last two decades, the majority of women will still die from progression of EOC. Optimal cytoreductive surgery and cytotoxic chemotherapy remains the mainstay of treatment in the front-line setting. Approximately 18% of EOCs harbor germline mutations of the tumor suppressor genes Breast Cancer Susceptibility Gene 1 (BRCA1) and 2 (BRCA2), while another 3–6% of these tumors have somatic mutations of these genes. These mutations lead to increased predisposition of multiple cancers. In addition, BRCA1 and BRCA2 genes encode proteins that are implicated in the Homologous Recombination (HR) mechanism, which is responsible for the repair of DNA Double Strand Breaks (DSBs), which is a common mechanism of action of chemotherapy. The incorporation of BRCA-targeted therapies, such as poly ADP ribose polymerase (PARP) inhibitors in the treatment algorithm of advanced EOC has further improved outcomes and represents a successful strategy of individualization of treatment in EOC. In this review, we summarize current treatment recommendations for patients with EOC and a BRCA1/2 mutation.
晚期(FIGO III期和IV期)癌症上皮癌(aEOC)占西方国家妇科癌症死亡的大多数。尽管这种疾病的预后在过去二十年中得到了显著改善,但大多数女性仍将死于EOC的进展。最佳的细胞还原手术和细胞毒性化疗仍然是一线治疗的主要手段。大约18%的EOC具有肿瘤抑制基因乳腺癌症易感性基因1(BRCA1)和2(BRCA2)的种系突变,而另外3-6%的肿瘤具有这些基因的体细胞突变。这些突变会增加患多种癌症的易感性。此外,BRCA1和BRCA2基因编码与同源重组(HR)机制有关的蛋白质,该机制负责修复DNA双链断裂(DSBs),这是化疗的常见作用机制。在晚期EOC的治疗算法中加入BRCA靶向治疗,如聚ADP核糖聚合酶(PARP)抑制剂,进一步改善了疗效,并代表了EOC个性化治疗的成功策略。在这篇综述中,我们总结了目前对EOC和BRCA1/2突变患者的治疗建议。
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引用次数: 0
The prognostic significance of microsatellite status and its relationship with tumor-infiltrating lymphocyte in endometrial cancer 子宫内膜癌症微卫星状态及其与肿瘤浸润淋巴细胞关系的预后意义
IF 0.4 4区 医学 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2021-06-15 DOI: 10.31083/J.EJGO.2021.03.2287
S. Lacin, G. E. Tasar, A. Usubutun, Z. Arık, D. Yuce, M. Salman, A. Kars
Department of Medical Oncology, Yeditepe University, Faculty of Medicine, Koşuyolu Mah. Koşuyolu Cad. No:168 34718 Kadıköy/İstanbul, Turkey Department of Pathology, Hacettepe University, Faculty of Medicine, 06100 Altındağ, Ankara, Turkey Department of Medical Oncology, Hacettepe University, Cancer Institute, 06100 Altındağ, Ankara, Turkey Department of Preventive Oncology, Hacettepe University, Hacettepe Cancer Institute, 06100 Altındağ, Ankara, Turkey Department of Obstetrics and Gynecology, Hacettepe University, Faculty of Medicine, 06100 Altındağ, Ankara, Turkey
叶迪特佩大学医学院肿瘤医学系,Koşuyolu Mah。Koşuyolu Cad。编号:168 34718 Kadı,土耳其哈切特佩大学医学院土耳其妇产科,06100 Altındağ,土耳其安卡拉
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引用次数: 0
Incidence and predictors of venous thromboembolism after surgery for gynecologic cancer 妇科肿瘤术后静脉血栓栓塞的发生率及预测因素
IF 0.4 4区 医学 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2021-06-15 DOI: 10.31083/j.ejgo.2021.03.2240
Xiao-juan Wang, K. Hua
Objective: To describe the incidence, timing, and risk factors of venous thromboembolism (VTE) after surgery for gynecological cancer and to evaluate its effects of these events on survival. Methods: This was a retrospective analysis from January 2008 through December 2016 at a single center. Data were recorded on surgical procedures, patient demographic characteristics, type of malignancy and VTE, and mortality outcomes within 30 days after surgery. Significant variables related to VTE were evaluated using bivariate analysis, and Logistic regression models were used to assess risk factors for VTE. Results: The overall rate of postoperative VTE was 0.899% (36/4005) within 30 days after surgery. Of these rates, the rate in abdominal surgery was 1.56% (19/1220), and the rate in minimally invasive surgery (MIS) was 0.6% (17/2785). The median time from surgery to diagnosis was 8.5 days. In univariate analysis, VTE was statistically significantly associated with ovarian and fallopian cancer (P < 0.05), older age (P = 0.001), and blood transfusion (P < 0.001). A multivariate logistic regression model was used to adjust for variables with P < 0.2 in univariate analysis and found that except for age, the other variables continued to have a significant association with VTE. Conclusion: The second week after surgery might be high-risk period of VTE occuring, and ovarian and fallopian tube cancer, abdominal surgery, and blood transfusion might be significant risk factors for developing VTE.
目的:描述妇科癌症术后静脉血栓栓塞(VTE)的发生率、发生时间和危险因素,并评价其对生存的影响。方法:这是2008年1月至2016年12月在一个中心进行的回顾性分析。记录手术过程、患者人口统计学特征、恶性肿瘤和VTE类型以及手术后30天内的死亡率结果。使用双变量分析评估与VTE相关的显著变量,并使用Logistic回归模型评估VTE的风险因素。结果:术后30天内VTE总发生率为0.899%(36/4005)。在这些比率中,腹部手术的比率为1.56%(19/1220),微创手术(MIS)的比率为0.6%(17/2785)。从手术到确诊的中位时间为8.5天。在单变量分析中,VTE与卵巢和输卵管癌症(P<0.05)、年龄较大(P=0.001)和输血(P<0.001)具有统计学显著相关性。使用多变量逻辑回归模型调整单变量分析的P<0.2的变量,发现除年龄外,其他变量与VTE仍有显著相关性。结论:术后第2周可能是VTE发生的高危期,卵巢和输卵管癌症、腹部手术和输血可能是发生VTE的重要危险因素。
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引用次数: 1
Methylated p16 gene is associated with negative expression of estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 in breast cancer 甲基化p16基因与乳腺癌症雌激素受体、孕激素受体和人表皮生长因子受体2的负表达相关
IF 0.4 4区 医学 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2021-06-15 DOI: 10.31083/J.EJGO.2021.03.2173
Shun Zhang, Ya-Qin Wang, Jing-hua Zhang, Jiwei Hu, Jie Ma, Z. Gu, Yu Wang, Jingjing Chen
Objective: This study was conducted to determine the relationship between p16 gene methylation and expression of relevant receptors in breast cancer (BC) for subtyping the disease. Methods: Methylationspecific PCR (MSP) was carried out to detect the methylation status of p16 gene in 240 tissue samples and 205 serum samples from BC patients treated at our hospital. Immunohistochemistry was used to determine the expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). Receiver operating characteristics (ROC) curve was analyzed for diagnostic value based on methylation status for triple-negative (TN) BC. Results: The overall methylation rates of the p16 gene were 36.7% (88/240) and 35.1% (72/205) in the tissue and serum samples, respectively. In patients with ER, PR and HER2-TNBC, the methylation rate of the p16 gene was significantly higher than that in non-triple negative patients (84.9%, 62/73) vs (25.9%, 35/135, P<0.01). The methylation of p16 gene was negatively associated with the expression of ER, PR and HER2 (r = -0.661, -0.694 and -0.765, respectively, P < 0.05), but it was not correlated with the pathological characteristics of BC, such as tumor grade and lymph-node metastasis. Receiver operator characteristic (ROC) curve analysis showed that p16 gene methylation had a significant diagnostic value for TNBC with an AUC of 0.815. Therefore, p16 gene methylation is associated with the subtype of TNBC and can be used as an easy and non-invasive approach to screen patients for TNBC.
目的:本研究旨在确定乳腺癌(BC)中p16基因甲基化与相关受体表达的关系,以确定乳腺癌亚型。方法:采用甲基化特异性PCR (Methylationspecific PCR, MSP)检测我院收治的240例BC患者组织标本和205例BC患者血清标本p16基因甲基化状态。免疫组化法检测雌激素受体(ER)、孕激素受体(PR)和人表皮生长因子受体2 (HER2)的表达。根据甲基化状态分析受试者工作特征(ROC)曲线对三阴性(TN) BC的诊断价值。结果:p16基因在组织和血清中的甲基化率分别为36.7%(88/240)和35.1%(72/205)。在ER、PR和HER2-TNBC患者中,p16基因甲基化率显著高于非三阴性患者(84.9%,62/73)和(25.9%,35/135,P<0.01)。p16基因的甲基化与ER、PR和HER2的表达呈负相关(r分别为-0.661、-0.694和-0.765,P < 0.05),但与BC的肿瘤分级、淋巴结转移等病理特征无关。ROC曲线分析显示,p16基因甲基化对TNBC具有显著的诊断价值,AUC为0.815。因此,p16基因甲基化与TNBC亚型相关,可作为筛查TNBC患者的一种简单且无创的方法。
{"title":"Methylated p16 gene is associated with negative expression of estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 in breast cancer","authors":"Shun Zhang, Ya-Qin Wang, Jing-hua Zhang, Jiwei Hu, Jie Ma, Z. Gu, Yu Wang, Jingjing Chen","doi":"10.31083/J.EJGO.2021.03.2173","DOIUrl":"https://doi.org/10.31083/J.EJGO.2021.03.2173","url":null,"abstract":"Objective: This study was conducted to determine the relationship between p16 gene methylation and expression of relevant receptors in breast cancer (BC) for subtyping the disease. Methods: Methylationspecific PCR (MSP) was carried out to detect the methylation status of p16 gene in 240 tissue samples and 205 serum samples from BC patients treated at our hospital. Immunohistochemistry was used to determine the expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). Receiver operating characteristics (ROC) curve was analyzed for diagnostic value based on methylation status for triple-negative (TN) BC. Results: The overall methylation rates of the p16 gene were 36.7% (88/240) and 35.1% (72/205) in the tissue and serum samples, respectively. In patients with ER, PR and HER2-TNBC, the methylation rate of the p16 gene was significantly higher than that in non-triple negative patients (84.9%, 62/73) vs (25.9%, 35/135, P<0.01). The methylation of p16 gene was negatively associated with the expression of ER, PR and HER2 (r = -0.661, -0.694 and -0.765, respectively, P < 0.05), but it was not correlated with the pathological characteristics of BC, such as tumor grade and lymph-node metastasis. Receiver operator characteristic (ROC) curve analysis showed that p16 gene methylation had a significant diagnostic value for TNBC with an AUC of 0.815. Therefore, p16 gene methylation is associated with the subtype of TNBC and can be used as an easy and non-invasive approach to screen patients for TNBC.","PeriodicalId":11903,"journal":{"name":"European journal of gynaecological oncology","volume":"42 1","pages":"530-536"},"PeriodicalIF":0.4,"publicationDate":"2021-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46112395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Prophylactic mastectomy and ovariectomy—a religious perspective 预防性乳房切除术和卵巢切除术——宗教观点
IF 0.4 4区 医学 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2021-06-15 DOI: 10.31083/J.EJGO.2021.03.2253
B. Kasprzak, Przemysław Zgórecki
Prophylactic mastectomy and ovariectomy doesn't seem to be a religious problem at first, therefore not much research on the subject has been done so far. As the awareness of the problem of breast and ovarian cancer threat and subsequently of the issue of prophylactic procedures for BRCA carriers is growing among general public, it is worth to ask the question if and in what way religion itself as well as religious communities may help. The article explores the impact of religious perspective on both physicians and patients as they face these problems. The issue is discussed from physicians' and chaplains' perspective. In the context of this discussion the question of involvement of religious communities in providing better information and support to patients-members of these communities is asked. The aim of the research done here is to open discussion on the possibility of providing better medical and spiritual help, with greater respect and empathy to every patient, no matter their religious and/or cultural background, by involving religious perspective in the process.
预防性乳房切除术和卵巢切除术起初似乎不是一个宗教问题,因此到目前为止,对这个主题的研究还不多。随着公众对乳腺癌和卵巢癌癌症威胁问题以及随后对BRCA携带者预防程序问题的认识不断提高,有必要问一个问题,宗教本身以及宗教团体是否以及以何种方式可能有所帮助。这篇文章探讨了宗教观点对医生和患者面临这些问题的影响。这个问题是从医生和牧师的角度来讨论的。在这一讨论的背景下,提出了宗教社区参与为这些社区的患者成员提供更好的信息和支持的问题。这里所做的研究的目的是通过将宗教观点纳入这一过程,就提供更好的医疗和精神帮助的可能性展开讨论,对每一位患者,无论其宗教和/或文化背景如何,都给予更大的尊重和同情。
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引用次数: 0
Proceedings of Asociación Aragonesa de Ginecología y Obstetricia (AGOA) 2021 congress 阿拉贡妇产科协会会议录(AGOA)2021年大会
IF 0.4 4区 医学 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2021-06-15 DOI: 10.31083/J.EJGO.2021.03.2021
L. B. Mainar
Marta Lamarca Ballestero*, Leticia Álvarez Sarrado, Javier Navarro Sierra, Yasmina José Gutiérrez, Isabel Negredo Quintana, Miguel Angel Ruiz Conde Department of Gynecology, Miguel Servet University Hospital, Paseo Isabel la Católica 1-3, 50009 Zaragoza, Spain. * m.lamarca@yahoo.es Objectives: To describe the clinical findings, treatment, and outcome of borderline ovarian tumors in 32 premenopausal patients admitted to the Miguel Servet University Hospital over a 17-year period. Methods: Thirty-two premenopausal patients diagnosed and treated from 2003 to 2020 for borderline ovarian tumors were retrospectively evaluated. Results: The 32 borderline included 12 serous, 19 mucinous, and 1 endometrioid tumors, 2 of them were of stage more than I. The average age of the patients was 34.5 years (14–45), 22 were symptomatic, pain being the most frequent symptom (68.8%). 8 patients were operated on primarily by laparoscopy and 24 by laparotomy. In the laparoscopy group, median tumor diameter was smaller (7.5 versus 14.7 cm, p = 0.019) and surgeries were less extensive, without hysterectomy, as compared to the laparotomy group. There were 21 fertility-sparing surgeries, 7 patients attempted a subsequent pregnancy and in 6 cases a pregnancy with a healthy child was obtained (2 using assisted reproductive techniques). During the 7–108 months follow-up time, there were 3 relapses: 2 borderline tumors (treated surgically and desease free) and 1 carcinoma treated with surgery and chemotherapy that ended in death due to cancer. Discussion: In our study, only 6.25% of the borderline tumors were of stage more than I, whereas other studies report a higher proportion of more advanced stages (7.5–18.5%). As borderline ovarian tumors more often arise in young women, in whom malignancy is less common and who wish to preserve their fertility, their initial surgery is often laparoscopy. Conclusions: Borderline ovarian tumors have an excellent prognosis. Good results are provided in young patients wishing to preserve fertility.
Marta Lamarca Ballestero*、LeticiaÁlvarez Sarrado、Javier Navarro Sierra、Yasmina JoséGutiérrez、Isabel Negredo Quintana、Miguel Angel Ruiz Conde妇科,Miguel Servet大学医院,Paseo Isabel la Católica 1-350009,西班牙萨拉戈萨。*m.lamarca@yahoo.es目的:描述Miguel Servet大学医院17年来收治的32名绝经前患者的交界性卵巢肿瘤的临床表现、治疗和结果。方法:对2003年至2020年诊断和治疗的32例绝经前交界性卵巢肿瘤患者进行回顾性评价。结果:32例交界性肿瘤包括12例浆液性肿瘤、19例粘液性肿瘤和1例子宫内膜样肿瘤,其中2例超过I期。患者平均年龄34.5岁(14-45岁),22例有症状,疼痛是最常见的症状(68.8%)。8例主要通过腹腔镜手术,24例通过剖腹手术。与剖腹手术组相比,腹腔镜组的中位肿瘤直径较小(7.5与14.7 cm,p=0.019),手术范围较小,无子宫切除术。有21例保留生育能力的手术,7例患者尝试了后续妊娠,6例患者获得了健康孩子的妊娠(2例使用辅助生殖技术)。在7-108个月的随访时间内,有3例复发:2例交界性肿瘤(手术治疗且无病)和1例接受手术和化疗的癌症,最终因癌症死亡。讨论:在我们的研究中,只有6.25%的交界性肿瘤的分期高于I期,而其他研究报告的晚期肿瘤比例更高(7.5-18.5%)。由于交界性卵巢肿瘤更常见于年轻女性,她们的恶性肿瘤不太常见,并且希望保持生育能力,因此她们最初的手术通常是腹腔镜手术。结论:卵巢交界性肿瘤预后良好。在希望保持生育能力的年轻患者中提供了良好的结果。
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引用次数: 0
Tumor proximity to serosal surface as an independent prognostic factor in FIGO stage 1 endometrial cancer 肿瘤靠近浆膜表面是FIGO 1期癌症的独立预后因素
IF 0.4 4区 医学 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2021-06-15 DOI: 10.31083/j.ejgo.2021.03.2310
L. Harbin, L. Berry, A. Wahlquist, J. Richmond, W. Graybill, M. Kohler, W. Creasman
Objective: Determine if tumor distance from serosal surface is an independent prognostic factor for disease recurrence and survival in stage 1 endometrial cancer. Methods: 747 patients diagnosed with stage 1 endometrial cancer between 1984 and 2015 were identified from an institutional database. This retrospective cohort was evaluated to assess di ferences in tumor distance from the serosal surface, histologic subtype, histologic grade, use of adjuvant treatment, recurrence rates and overall survival. Cox proportional hazard models were used to determine if variables of interest were related to recurrence and overall survival. Concordance correlation coe ficients were used to compare our model to the 2009 International Federation of Gynecology andObstetrics (FIGO) staging. Results: Tumor distance from serosal surface ranged from 0mm–21mm. 47 (8.7%) patients experienced recurrence. Patients with tumors located 5mmor less from the serosal surface were 2.24 times more likely to experience recurrent disease (HR 2.24, 95% CI: 1.16 to 4.31, p = 0.02). Concordance rates for disease recurrence were 0.573 and 0.583 for our tumor distance model compared to the 2009 FIGO staging (95% CI: 0.568 to 0.579 and 95% CI: 0.577 to 0.589). Conclusions: Our study demonstrates that patients with tumors located 5 mm or less from the serosal surface have a two-fold increased risk of recurrence. Concordance ratesarevery similarbetweenourmodelandthe2009FIGO staging suggesting comparable predictability; these rates suggest there is roomfor improvement inbothmethods topredict disease recurrence and survival.
目的:确定肿瘤与浆膜表面的距离是否是癌症1期疾病复发和生存的独立预后因素。方法:从机构数据库中确定1984年至2015年间诊断为癌症1期的747名患者。对该回顾性队列进行评估,以评估肿瘤与浆膜表面的距离、组织学亚型、组织学分级、辅助治疗的使用、复发率和总生存率的差异。Cox比例风险模型用于确定感兴趣的变量是否与复发和总生存率有关。使用一致性相关系数将我们的模型与2009年国际妇产科联合会(FIGO)的分期进行比较。结果:肿瘤距浆膜表面的距离为0~21mm。复发47例(8.7%)。肿瘤位于浆膜表面5毫米以下的患者复发疾病的可能性是其他患者的2.24倍(HR2.24,95%CI:1.16至4.31,p=0.02)。与2009年FIGO分期相比,我们的肿瘤距离模型的疾病复发符合率分别为0.573和0.583(95%CI:0.568至0.579,95%CI:0.577至0.589)。结论:我们的研究表明距离浆膜表面5mm或更小的肿瘤复发的风险增加了两倍。协和率与2009年FIGO分期之间几乎相似,这表明可预测性相当;这些发病率表明,在预测疾病复发和生存率的方法上还有改进的空间。
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引用次数: 0
Factors influencing cosmetic outcome of breast-conserving treatment in breast cancer: a narrative review 影响乳腺癌保乳治疗美容效果的因素:综述
IF 0.4 4区 医学 Q4 OBSTETRICS & GYNECOLOGY Pub Date : 2021-06-15 DOI: 10.31083/J.EJGO.2021.03.2285
A. Brands-Appeldoorn, S. Maaskant-Braat, L. Janssen, V. Tjan-Heijnen, R. Roumen
Background: A deformed breast following Breast-Conserving Treatment (BCT) is influenced by an array of factors encompassing final cosmesis. This overview examines the factors that may influence cosmetic outcome for BCT patients. Methods: Literature search was performed using PubMed and EMBASE databases. Research articles published in English (1990–2018) pertaining to patients that had previously undergone unilateral BCT for breast cancer were included. Results: 42 articles were used for our final analysis that utilized subjective and objective tools to assess cosmetic outcome. Factors can be allocated as patient, tumor, surgery, radiotherapy or systemic therapy associated. Based on significance in both univariable as well as multivariable analysis and frequency of reporting, extensiveness of primary tumor resection, tumor size, tumor location, adjuvant radiotherapy and adjuvant chemotherapy, were the factors affecting cosmetic outcome the most. Conclusions: In this study, we reviewed and discussed several patient-, tumorand treatment related factors affecting cosmetic outcome. Many different tools, either subjective or objective, are observed worldwide.
背景:保乳治疗(breast - conservation Treatment, BCT)后的畸形乳房受一系列包括最终美容在内的因素影响。本综述探讨了可能影响BCT患者美容结果的因素。方法:使用PubMed和EMBASE数据库进行文献检索。纳入了1990年至2018年期间发表的与之前接受过单侧乳腺癌BCT的患者相关的英文研究文章。结果:42篇文章用于我们的最终分析,使用主观和客观的工具来评估美容效果。因素可按患者、肿瘤、手术、放疗或全身治疗相关进行分配。从单变量分析和多变量分析的显著性以及报道频次来看,原发肿瘤切除的广泛性、肿瘤大小、肿瘤位置、辅助放疗和辅助化疗是影响美容效果的主要因素。结论:在本研究中,我们回顾并讨论了影响美容效果的几个与患者、肿瘤和治疗相关的因素。许多不同的工具,无论是主观的还是客观的,都在世界范围内被观察到。
{"title":"Factors influencing cosmetic outcome of breast-conserving treatment in breast cancer: a narrative review","authors":"A. Brands-Appeldoorn, S. Maaskant-Braat, L. Janssen, V. Tjan-Heijnen, R. Roumen","doi":"10.31083/J.EJGO.2021.03.2285","DOIUrl":"https://doi.org/10.31083/J.EJGO.2021.03.2285","url":null,"abstract":"Background: A deformed breast following Breast-Conserving Treatment (BCT) is influenced by an array of factors encompassing final cosmesis. This overview examines the factors that may influence cosmetic outcome for BCT patients. Methods: Literature search was performed using PubMed and EMBASE databases. Research articles published in English (1990–2018) pertaining to patients that had previously undergone unilateral BCT for breast cancer were included. Results: 42 articles were used for our final analysis that utilized subjective and objective tools to assess cosmetic outcome. Factors can be allocated as patient, tumor, surgery, radiotherapy or systemic therapy associated. Based on significance in both univariable as well as multivariable analysis and frequency of reporting, extensiveness of primary tumor resection, tumor size, tumor location, adjuvant radiotherapy and adjuvant chemotherapy, were the factors affecting cosmetic outcome the most. Conclusions: In this study, we reviewed and discussed several patient-, tumorand treatment related factors affecting cosmetic outcome. Many different tools, either subjective or objective, are observed worldwide.","PeriodicalId":11903,"journal":{"name":"European journal of gynaecological oncology","volume":"42 1","pages":"425-433"},"PeriodicalIF":0.4,"publicationDate":"2021-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46167014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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European journal of gynaecological oncology
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