European Journal of Nuclear Medicine and Molecular Imaging最新文献

{"title":"Editorial Commentary: Should “heterogeneous response” be considered as new category for assessing treatment response in patients with breast cancer?","authors":"Sofia C. Vaz, David Groheux, Thiemo van Nijnatten, Lidija Antunovic, Fatima Cardoso, Felix Mottaghy, Maria Joao Cardoso, Christopher Riedl, Lioe-Fee de Geus-Oei, Gary A. Ulaner","doi":"10.1007/s00259-024-07042-9","DOIUrl":"https://doi.org/10.1007/s00259-024-07042-9","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"56 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142867009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"This union must happen: Radiomics and LAFOV PET/CT as the power couple of nuclear medicine.","authors":"Luca Filippi, Francesco Bianconi, Orazio Schillaci, Barbara Palumbo","doi":"10.1007/s00259-024-07045-6","DOIUrl":"https://doi.org/10.1007/s00259-024-07045-6","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying and navigating bottlenecks in the translation of novel radiopharmaceuticals: a perspective.","authors":"Margret Schottelius","doi":"10.1007/s00259-024-07020-1","DOIUrl":"https://doi.org/10.1007/s00259-024-07020-1","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of dosimetry accuracy on the correlation with treatment outcome in a preliminary PSMA radiopharmaceutical therapy study","authors":"Jiaxi Hu, Robert Seifert, Sofia Karkampouna, Carlos Vinicius Gomes, Song Xue, Ali Afshar-Ormieh, Axel Rominger, Kuangyu Shi","doi":"10.1007/s00259-024-07010-3","DOIUrl":"https://doi.org/10.1007/s00259-024-07010-3","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Introduction</h3><p>Despite the potential of dosimetry in optimizing personalized radiopharmaceutical therapy (RPT), its limited clinical implementation impedes the development of simplified protocols for routine adoption. However, simplifications may introduce errors in dosimetry, prompting questions about their impact on clinical practice.</p><h3 data-test=\"abstract-sub-heading\">Materials and methods</h3><p>In this retrospective study, we analyzed data from 21 patients diagnosed with metastatic castration-resistant prostate cancer (mCRPC) who underwent multiple cycles of ¹⁷⁷Lu-PSMA-617 RPT treatment. Cumulative dosimetry of all the treatment cycles was calculated using both the standard multi-time point dosimetry (MTPD) method and the single time-point dosimetry (STPD, Hänscheid approximation) method for the same cohort. Their correlations with treatment outcome (PSA decline rate and overall survival, OS) and complication risk (anaemia grade) were investigated. The Fisher's Z-Transformed test was performed to statistically evaluate the difference between the correlations.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>STPD showed a non-significant difference in correlation with PSA decline rate, despite a mean percentage error (MPE) of up to 36.44% in tumor dosimetry compared to MTPD (MTPD: rho = -0.39, <i>p</i> &lt; 0.001; STPD: rho = -0.46, <i>p</i> &lt; 0.001; Z = 0.58, <i>p</i> = 0.56). Both STPD_total and MTPD_total demonstrated a significant impact on OS (STPD_total: Hazard Ratio = 1.05, <i>p</i> &lt; 0.05, log-transformed MTPD_total: Hazard Ratio = 3.41, <i>p</i> &lt; 0.05, log-transformed STPD_total: Hazard Ratio = 8.06, <i>p</i> &lt; 0.05). Additionally, despite a MPE of up to -40.26% in bone marrow dosimetry, STPD showed a non-significant difference in correlation with anemia grade (MTPD: rho = 0.35, <i>p</i> &lt; 0.001; STPD: rho = 0.40, <i>p</i> &lt; 0.001; Z = -0.39, <i>p</i> = 0.70).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>The preliminary findings from a small cohort indicate that the reduced accuracy of a clinically simplified protocol may not diminish the clinical therapy outcome predictive value of dosimetry. Future thorough systematic investigations may be needed to determine the clinically acceptable level of accuracy for dosimetry.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"31 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GD2-targeted theranostics of neuroblastoma with [64Cu]Cu/[177Lu]Lu-hu3F8","authors":"Lingling Zheng, Cuicui Li, Xu Yang, Jun Liu, Guanyun Wang, Ziang Zhou, Xianyu Zhu, Jianhua Gong, Jigang Yang","doi":"10.1007/s00259-024-07033-w","DOIUrl":"https://doi.org/10.1007/s00259-024-07033-w","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Neuroblastoma (NB) is a malignant embryonic tumour with poor prognosis and high mortality rate. The antigen gisialoganglioside (GD2), which is highly expressed on the surface of NB cells, is an effective target for therapy. This study aims to evaluate the GD2 expression with [⁶⁴Cu]Cu-NOTA-hu3F8 positron emission tomography (PET) imaging and explore the radioimmunotherapy (RIT) effect of [¹⁷⁷Lu]Lu-DOTA-hu3F8 in NB tumour models.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>The in vitro validation of the binding ability of anti-GD2 humanised monoclonal antibody (hu3F8) to GD2 was achieved via flow cytometry, cell immunofluorescence, and cell uptake test. Hu3F8 were conjugated with p-SCN-Bn-NOTA (NOTA) and p-SCN-Bn-DOTA (DOTA) for ⁶⁴Cu- and ¹⁷⁷Lu- radiolabelling. PET imaging and RIT studies were conducted using [⁶⁴Cu]Cu-NOTA-hu3F8 and [¹⁷⁷Lu]Lu-DOTA-hu3F8 in subcutaneous NB tumour models.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The Institute for Medical Research-32 (IMR32) cell line exhibited a specific binding ability of hu3F8. PET imaging demonstrated a specific accumulation of [⁶⁴Cu]Cu-NOTA-hu3F8 in IMR32 tumour models, with a maximum tumour uptake of 23.73 ± 2.29%ID/g (<i>n</i> = 3) at 72 h post-injection (p.i.), outperforming other groups significantly (<i>P</i> &lt; 0.001). The high dose [¹⁷⁷Lu]Lu-DOTA-hu3F8 group (11.1MBq) showed the most potent tumour suppression, with a standardised tumour volume of about 20.47 ± 6.32% at 30 days p.i., significantly smaller than other groups (<i>n</i> = 5, <i>P</i> &lt; 0.05).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>This study demonstrated that ⁶⁴Cu-/¹⁷⁷Lu- labelled hu3F8 could noninvasively evaluate the GD2 expression and effectively inhibit tumour growth in NB tumour models. The excellent therapeutic efficacy of [¹⁷⁷Lu]Lu-DOTA-hu3F8 may be helpful for the clinical translation of this GD2-targeted theranostics approach in GD2-positive tumours.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"24 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of cerebral amyloid angiopathy with ipsilateral tau and contralateral amyloid PET uptake related to cadaveric dura mater implanted in childhood.","authors":"Yuki Hatakeyama, Atsushi Michael Kimura, Shintaro Tsuboguchi, Mikhail Ratanov, Kosei Nakamura, Masahiro Hatakeyama, Yukimi Nakamura, Masaki Watanabe, Yoshihiro Murakami, Yuko Saito, Shigeo Murayama, Kensaku Kasuga, Takeshi Ikeuchi, Hironaka Igarashi, Osamu Onodera, Hitoshi Shimada","doi":"10.1007/s00259-024-07030-z","DOIUrl":"https://doi.org/10.1007/s00259-024-07030-z","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":" ","pages":""},"PeriodicalIF":8.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subcortical tau deposition and plasma glial fibrillary acidic protein as predictors of cognitive decline in mild cognitive impairment and Alzheimer’s disease","authors":"Yan Chang, Jiajin Liu, Xiaodan Xu, Shuwei Sun, Jinming Zhang, Xiaojun Zhang, Guangshuang Lu, Shaobo Xiao, Yuanyan Cao, Runze Wu, Jun Wu, Ruozhuo Liu, Ruimin Wang","doi":"10.1007/s00259-024-07016-x","DOIUrl":"https://doi.org/10.1007/s00259-024-07016-x","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>This study aimed to investigate the correlation between subcortical tau-positron emission tomography (Tau-PET) and plasma glial fibrillary acidic protein (GFAP) levels and cognitive function in participants with cognitively unimpaired (CU), mild cognitive impairment (MCI) and Alzheimer’s disease (AD) conditions.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>105 participants with amyloid (Aβ) PET and Tau-PET scans were enrolled. Region of interest (ROI) level and voxel-wise comparisons were performed between those three groups. Correlations between standardized uptake value ratio (SUVR) and cognitive performance were analyzed. The diagnostic performance of Tau-PET, Aβ-PET, and plasma GFAP, both individually and combined, was evaluated by calculating the area under the curve (AUC) from receiver operating characteristic (ROC) analyses.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Plasma GFAP levels in the AD and MCI groups were higher than those in the CU group. The AD and MCI groups showed higher Tau-PET load at the amygdala, accumbens, putamen, pallidum, hippocampus, para-hippocampus and olfactory tubercle than the CU group (<i>p</i> &lt; 0.05). In the MCI group, the mean tau SUVR in the combined subcortical ROI negatively correlated with cognitive scores (<i>r</i> = -0.38, <i>p</i> = 0.02). The combination of Tau-PET, Aβ-PET and plasma GFAP provided optimal diagnostic accuracy for classifying AD from MCI, with an AUC of 0.82, a sensitivity of 0.69 and a specificity of 0.81.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>Subcortical tau deposition and increased plasma GFAP levels are associated with cognitive impairment in MCI patients.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"48 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First-in-human SPECT/CT imaging of [211At]PSMA-5: targeted alpha therapy in a patient with refractory prostate cancer","authors":"Tadashi Watabe, Koji Hatano, Sadahiro Naka, Hidetaka Sasaki, Takashi Kamiya, Yoshifumi Shirakami, Atsushi Toyoshima, Jens Cardinale, Frederik L. Giesel, Kayako Isohashi, Norio Nonomura, Noriyuki Tomiyama","doi":"10.1007/s00259-024-07017-w","DOIUrl":"https://doi.org/10.1007/s00259-024-07017-w","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"39 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142832001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"18F-FDG PET/CT: The turning point in eosinophilic fasciitis diagnosis in a pediatric patient","authors":"Elizabeth Katherine Anna Triumbari, Milena Pizzoferro, Maria Felicia Villani, Claudio Altini, Saadi Sollaku, Emanuele Casciani, Maria Luisa D’Andrea, Antonella Insalaco, Maria Carmen Garganese","doi":"10.1007/s00259-024-07026-9","DOIUrl":"https://doi.org/10.1007/s00259-024-07026-9","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"12 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142832002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A deep learning method for total-body dynamic PET imaging with dual-time-window protocols","authors":"Wenxiang Ding, Hanzhong Wang, Xiaoya Qiao, Biao Li, Qiu Huang","doi":"10.1007/s00259-024-07012-1","DOIUrl":"https://doi.org/10.1007/s00259-024-07012-1","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Prolonged scanning durations are one of the primary barriers to the widespread clinical adoption of dynamic Positron Emission Tomography (PET). In this paper, we developed a deep learning algorithm that capable of predicting dynamic images from dual-time-window protocols, thereby shortening the scanning time.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>This study includes 70 patients (mean age ± standard deviation, 53.61 ± 13.53 years; 32 males) diagnosed with pulmonary nodules or breast nodules between 2022 to 2024. Each patient underwent a 65-min dynamic total-body [¹⁸F]FDG PET/CT scan. Acquisitions using early-stop protocols and dual-time-window protocols were simulated to reduce the scanning time. To predict the missing frames, we developed a bidirectional sequence-to-sequence model with attention mechanism (Bi-AT-Seq2Seq); and then compared the model with unidirectional or non-attentional models in terms of Mean Absolute Error (MAE), Bias, Peak Signal-to-Noise Ratio (PSNR), and Structural Similarity (SSIM) of predicted frames. Furthermore, we reported the comparison of concordance correlation coefficient (CCC) of the kinetic parameters between the proposed method and traditional methods.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The Bi-AT-Seq2Seq significantly outperform unidirectional or non-attentional models in terms of MAE, Bias, PSNR, and SSIM. Using a dual-time-window protocol, which includes a 10-min early scan followed by a 5-min late scan, improves the four metrics of predicted dynamic images by 37.31%, 36.24%, 7.10%, and 0.014% respectively, compared to the early-stop protocol with a 15-min acquisition. The CCCs of tumor’ kinetic parameters estimated with recovered full time-activity-curves (TACs) is higher than those with abbreviated TACs.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>The proposed algorithm can accurately generate a complete dynamic acquisition (65 min) from dual-time-window protocols (10 + 5 min).</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"23 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142832003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}