{"title":"Prediction of alzheimer's disease time to dementia onset using cross-sectional data from spatiotemporal biomarker progression patterns.","authors":"Tianhao Zhang,Binbin Nie,Hua Liu,Guangjuan Mao,Chujun OuYang,Xiaochen Jiang,Baoci Shan","doi":"10.1007/s00259-026-07797-3","DOIUrl":"https://doi.org/10.1007/s00259-026-07797-3","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"415 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147393805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-10DOI: 10.1007/s00259-026-07799-1
Andrea Di Giorgio,Marco Rapa,Martina Di Franco,Caterina Maria Paola Sgro,Giambattista Siepe,Veronica Mollica,Lorenzo Bianchi,Matteo Droghetti,Paolo Castellucci,Riccardo Mei,Andrea Farolfi,Riccardo Schiavina,Stefano Fanti
{"title":"Omitted staging PSMA PET/CT is associated with advance disease extent at time of PSA persistence: a single center retrospective analysis.","authors":"Andrea Di Giorgio,Marco Rapa,Martina Di Franco,Caterina Maria Paola Sgro,Giambattista Siepe,Veronica Mollica,Lorenzo Bianchi,Matteo Droghetti,Paolo Castellucci,Riccardo Mei,Andrea Farolfi,Riccardo Schiavina,Stefano Fanti","doi":"10.1007/s00259-026-07799-1","DOIUrl":"https://doi.org/10.1007/s00259-026-07799-1","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"299 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147383465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-09DOI: 10.1007/s00259-026-07812-7
Anubhav Datta, William Spiller, Hitesh Mistry, Peter Julyan, James PB O’Connor, Ahmed Salem, Corinne Faivre-Finn, Prakash Manoharan
{"title":"Evaluating the prognostic impact of multiple 18FDG-PET imaging parameters in small-cell lung cancer: Insights from the long-term analysis of the CONVERT trial","authors":"Anubhav Datta, William Spiller, Hitesh Mistry, Peter Julyan, James PB O’Connor, Ahmed Salem, Corinne Faivre-Finn, Prakash Manoharan","doi":"10.1007/s00259-026-07812-7","DOIUrl":"https://doi.org/10.1007/s00259-026-07812-7","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"251 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147373863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The [18F]FDG PET/CT for prognostic stratification in multiple myeloma: A systematic review and meta-analysis.","authors":"Meiling Xiao,Yuan Sun,Yuhan Chen,Ke Liu,Jing Wang,Han Hao,Daoyan Hu,Xiaohui Zhang,Yan Zhong,Mei Tian,Hong Zhang","doi":"10.1007/s00259-026-07830-5","DOIUrl":"https://doi.org/10.1007/s00259-026-07830-5","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"52 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147368384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PURPOSETo assess the clinical value of single-time-point dosimetry for [¹⁷⁷Lu]Lu-PSMA-617 radioligand therapy in patients with metastatic castration-resistant prostate cancer (mCRPC).METHODSFifty-nine patients with progressive mCRPC expressing PSMA and previously treated with androgen receptor pathway inhibitors and taxane-based chemotherapy were retrospectively analysed. SPECT/CT imaging was performed after the first (C1) and fourth (C4) [¹⁷⁷Lu]Lu-PSMA-617 infusions on 360°-CZT camera. Automated segmentation and dosimetry protocols were applied to quantify absorbed doses in bone marrow and lesions. Dose-effect relationships were assessed using blood counts, PSA responses (PSA50 criteria), and PET imaging. Statistical analyses included Spearman correlation, Wilcoxon signed-rank test, and logistic regression.RESULTSBone marrow absorbed dose (BMAD) at C1 was significantly correlated with red blood cells (RBC, ρ = -0.3) and haemoglobin (ρ = -0.26) decline. A higher BMAD was associated with greater declines in RBC count (median [IQR] 0.31 [0.33] Gy vs. 0.076 [0.19], p < 0.05) and haemoglobin (0.29 [0.41] vs. 0.092 [0.20], p = 0.056). A moderate negative correlation was found between PSA variation and total metastatic tumour absorbed (TMTAD) dose at C1 (ρ = -0.35) and from C1 to C4 (ρ = -0.35). Response modelling (based on PSA50) estimated 50% and 80% probabilities of response at 8.8 Gy and 18.1 Gy for TMTAD(C1) and at 11.3 Gy and 31.7 Gy for TMTAD(C1-C4).CONCLUSIONSingle-time-point dosimetry for [¹⁷⁷Lu]Lu-PSMA-617 therapy in mCRPC is clinically relevant, demonstrating dose-dependent haematological decline and therapeutic response. This approach has the potential to facilitate more personalised and accessible radioligand therapy.
{"title":"Clinical value of per-treatment whole-body single-time-point automated dosimetry for [177Lu]Lu-PSMA-617 therapy in metastatic castration-resistant prostate cancer.","authors":"Arnaud Dieudonné,Aya Terro,Arthur Dumouchel,Solène Perret,Adrien Pommier,Agathe Edet-Sanson,Pierre Vera,Frédéric Di Fiore,Laetitia Augusto,Pierre Decazes,David Tonnelet","doi":"10.1007/s00259-026-07823-4","DOIUrl":"https://doi.org/10.1007/s00259-026-07823-4","url":null,"abstract":"PURPOSETo assess the clinical value of single-time-point dosimetry for [¹⁷⁷Lu]Lu-PSMA-617 radioligand therapy in patients with metastatic castration-resistant prostate cancer (mCRPC).METHODSFifty-nine patients with progressive mCRPC expressing PSMA and previously treated with androgen receptor pathway inhibitors and taxane-based chemotherapy were retrospectively analysed. SPECT/CT imaging was performed after the first (C1) and fourth (C4) [¹⁷⁷Lu]Lu-PSMA-617 infusions on 360°-CZT camera. Automated segmentation and dosimetry protocols were applied to quantify absorbed doses in bone marrow and lesions. Dose-effect relationships were assessed using blood counts, PSA responses (PSA50 criteria), and PET imaging. Statistical analyses included Spearman correlation, Wilcoxon signed-rank test, and logistic regression.RESULTSBone marrow absorbed dose (BMAD) at C1 was significantly correlated with red blood cells (RBC, ρ = -0.3) and haemoglobin (ρ = -0.26) decline. A higher BMAD was associated with greater declines in RBC count (median [IQR] 0.31 [0.33] Gy vs. 0.076 [0.19], p < 0.05) and haemoglobin (0.29 [0.41] vs. 0.092 [0.20], p = 0.056). A moderate negative correlation was found between PSA variation and total metastatic tumour absorbed (TMTAD) dose at C1 (ρ = -0.35) and from C1 to C4 (ρ = -0.35). Response modelling (based on PSA50) estimated 50% and 80% probabilities of response at 8.8 Gy and 18.1 Gy for TMTAD(C1) and at 11.3 Gy and 31.7 Gy for TMTAD(C1-C4).CONCLUSIONSingle-time-point dosimetry for [¹⁷⁷Lu]Lu-PSMA-617 therapy in mCRPC is clinically relevant, demonstrating dose-dependent haematological decline and therapeutic response. This approach has the potential to facilitate more personalised and accessible radioligand therapy.","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"2 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147368383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-06DOI: 10.1007/s00259-026-07795-5
Sang-Geon Cho,Hong Sung Jung,Chang Seong Kim,Ki Seong Park,Jahae Kim,Ho Kyun Lee,Ho-Chun Song,Soo Jin Na Choi
{"title":"Prognostic significance of early cortical functional integrity measured by 99mTc-DMSA SPECT in kidney transplant recipients.","authors":"Sang-Geon Cho,Hong Sung Jung,Chang Seong Kim,Ki Seong Park,Jahae Kim,Ho Kyun Lee,Ho-Chun Song,Soo Jin Na Choi","doi":"10.1007/s00259-026-07795-5","DOIUrl":"https://doi.org/10.1007/s00259-026-07795-5","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"48 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147359388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-06DOI: 10.1007/s00259-026-07794-6
Francesco Dondi,Davide Lorenzo Bettini,Deborah Cosentini,Roberta Ambrosini,Sara Rodella,Benedetta Trevisan,Andrea Abate,Mariangela Tamburello,Valentina Cremaschi,Giovanni Casole,Guido Alberto Massimo Tiberio,Sandra Sigala,Salvatore Grisanti,Francesco Bertagna,Alfredo Berruti,Marta Laganà
{"title":"Prognostic role of pretreatment [18F]FDG PET/CT in patients affected by adrenocortical carcinoma and treated with chemotherapy.","authors":"Francesco Dondi,Davide Lorenzo Bettini,Deborah Cosentini,Roberta Ambrosini,Sara Rodella,Benedetta Trevisan,Andrea Abate,Mariangela Tamburello,Valentina Cremaschi,Giovanni Casole,Guido Alberto Massimo Tiberio,Sandra Sigala,Salvatore Grisanti,Francesco Bertagna,Alfredo Berruti,Marta Laganà","doi":"10.1007/s00259-026-07794-6","DOIUrl":"https://doi.org/10.1007/s00259-026-07794-6","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"82 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147359387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The 68Ga-siderophore approach to infection imaging: evaluation of [68Ga]Ga-DFO in patients with vascular graft infection.","authors":"Sally F Barrington,Margaret Cooper,Georgios Krokos,Zilin Yu,Afnan Mf Darwesh,Victoria Gibson,Ronan Tegala,Julia E Blower,Maria Dibua,Armidita Jacob,Joemon John,Sofia Pereira,Laura Cole,Nicholas Price,Morad Sallam,Philip J Blower","doi":"10.1007/s00259-026-07831-4","DOIUrl":"https://doi.org/10.1007/s00259-026-07831-4","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"1 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147359386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-06DOI: 10.1007/s00259-026-07798-2
Zehua Zhu,Ming Ni,Xinyi Lv,Jiyong Peng,Feng Gao,Bo Pan,Yong Shen,Shicun Wang,Jiong Shi
{"title":"Regional cerebral hypometabolism and pathological heterogeneity in sporadic early onset alzheimer's disease: China Aging and Neurodegenerative Initiative (CANDI) study.","authors":"Zehua Zhu,Ming Ni,Xinyi Lv,Jiyong Peng,Feng Gao,Bo Pan,Yong Shen,Shicun Wang,Jiong Shi","doi":"10.1007/s00259-026-07798-2","DOIUrl":"https://doi.org/10.1007/s00259-026-07798-2","url":null,"abstract":"","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"8 1","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147359170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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