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The decalogue of the 2024 European Heart Rhythm Association/Heart Rhythm Society/Asia Pacific Heart Rhythm Society/Latin American Heart Rhythm Society consensus document on catheter and surgical ablation of atrial fibrillation. 2024年欧洲心律协会/心律学会/亚太心律学会/拉丁美洲心律学会共识文件关于房颤导管和手术消融的十诫。
IF 39.3 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-01-17 DOI: 10.1093/eurheartj/ehae375
Stylianos Tzeis,Alireza Sepehri Shamloo
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引用次数: 0
Familial hypercholesterolaemia: how to further improve outcomes. 家族性高胆固醇血症:如何进一步改善预后。
IF 39.3 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-01-17 DOI: 10.1093/eurheartj/ehae834
Vera Bittner
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引用次数: 0
The Kosovo Society of Cardiology: the youngest member in the ESC family. 科索沃心脏病学会:ESC家族中最年轻的成员。
IF 39.3 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-01-17 DOI: 10.1093/eurheartj/ehae785
Gani Bajraktari
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引用次数: 0
Optical coherence tomography-based management of coronary plaque erosion following immune checkpoint inhibitors. 免疫检查点抑制剂后冠状动脉斑块侵蚀的光学相干断层扫描管理。
IF 39.3 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-01-17 DOI: 10.1093/eurheartj/ehae817
Yuma Ichikawa,Tsuyoshi Kobayashi,Akira Sato
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引用次数: 0
Ages at coronary heart disease and death in familial hypercholesterolaemia: a Danish nationwide study spanning 44 years 家族性高胆固醇血症的冠心病发病年龄和死亡:丹麦一项长达44年的全国性研究
IF 39.3 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-01-17 DOI: 10.1093/eurheartj/ehae912
Jacob Reeh, Shoaib Afzal, Anders Berg Wulff, Børge G Nordestgaard
Background and Aims Familial hypercholesterolaemia leads to lifelong elevated low-density lipoprotein cholesterol with increased risk of coronary heart disease and pre-mature death. It is unknown whether the prognosis for individuals with familial hypercholesterolaemia has improved over the past four decades as registration of this condition has been limited worldwide. However, in Danish nationwide registries, modified ICD coding has allowed such registration since 1978. This study tested the hypothesis that age at death and coronary heart disease has improved from 1978 to 2021 in individuals with vs. those without familial hypercholesterolaemia. Methods From nationwide registries, all Danish residents were included in a retrospective cohort study. Inclusion and follow-up were from 1978 to 2021. Individuals diagnosed with familial hypercholesterolaemia were identified, and trends over time were examined for age at death and age at coronary heart disease. Results During follow-up for those with (n = 10 199) and without (n = 9 174 926) familial hypercholesterolaemia, 27% and 27% died and 34% and 9% experienced coronary heart disease. Age at death was 22 years younger in 1978 (P < .001) but similar in 2021 (P = .16) in individuals with vs. without familial hypercholesterolaemia. Although the corresponding age at coronary heart disease was 20 years younger in 1978 (P < .001), it was still 7 years younger in 2021 (P < .001) in individuals with vs. without familial hypercholesterolaemia. These results were similar in women and men and in a 1:100 matched analysis by sex, ethnicity, and time of birth. Conclusions Nationwide from 1978 to 2021 in Denmark, normalization of age at death but not age at coronary heart disease was observed for individuals diagnosed with familial hypercholesterolaemia.
背景和目的家族性高胆固醇血症可导致低密度脂蛋白胆固醇终生升高,增加冠心病和过早死亡的风险。家族性高胆固醇血症患者的预后在过去40年中是否有所改善尚不清楚,因为这种疾病在全球范围内登记有限。然而,在丹麦全国登记中,自1978年以来修改的ICD编码已允许进行此类登记。该研究验证了这样一种假设,即1978年至2021年间,家族性高胆固醇血症患者与非家族性高胆固醇血症患者相比,死亡年龄和冠心病有所改善。方法从全国登记的丹麦居民中纳入回顾性队列研究。纳入和随访时间为1978年至2021年。确定了被诊断为家族性高胆固醇血症的个体,并检查了死亡年龄和冠心病年龄随时间的变化趋势。结果在随访期间,家族性高胆固醇血症患者(n = 10 199)和非家族性高胆固醇血症患者(n = 9 174 926)分别有27%和27%死亡,34%和9%发生冠心病。1978年的死亡年龄比现在小22岁(P <;.001),但在2021年,家族性高胆固醇血症患者与非家族性高胆固醇血症患者的差异相似(P = .16)。尽管1978年冠心病的相应年龄比当时年轻20岁(P <;.001),到2021年仍年轻7岁(P <;.001),在家族性高胆固醇血症患者和非家族性高胆固醇血症患者中。这些结果在女性和男性中是相似的,在1:100的匹配分析中,性别、种族和出生时间是相同的。从1978年到2021年,在丹麦全国范围内,在被诊断为家族性高胆固醇血症的个体中,观察到死亡年龄的正常化,但没有观察到冠心病的年龄。
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引用次数: 0
Long-term pulse pressure trajectories and risk of incident atrial fibrillation: the Tromsø Study 长期脉压轨迹和房颤发生的风险:特罗姆瑟研究
IF 39.3 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-01-17 DOI: 10.1093/eurheartj/ehaf005
Ekaterina Sharashova, Eva Gerdts, Jocasta Ball, Renate B Schnabel, Michael Stylidis, Sweta Tiwari, Ellisiv B Mathiesen, Tom Wilsgaard, Maja-Lisa Løchen
Background and Aims Sex-based differences in the association of long-term trends in pulse pressure with future risk of atrial fibrillation (AF) have been explored using data from the population-based Tromsø Study 1986–2016. Methods Women (n = 8331) and men (n = 7638) aged ≥20 years who attended at least two of the three Tromsø Study surveys conducted between 1986 and 2001 (the exposure period) were followed up for incident AF throughout 2016 (the follow-up period). Pulse pressure ≥60 mmHg was considered elevated. Group-based trajectory modelling and Cox regression were used for statistical analyses. Results Three long-term trajectory groups for pulse pressure were identified: Group 1 had normal pulse pressure throughout the exposure period, Group 2 had normal pulse pressure at the beginning and elevated pulse pressure at the end of the exposure period, and Group 3 had elevated pulse pressure throughout. Over the follow-up period, 568 (6.8%) women and 798 (10.5%) men developed AF. After adjustment for potential confounders at baseline, the long-term trajectory groups for elevated pulse pressure were associated with increased risk of AF in women, but not in men. In women, the adjusted hazard ratios of AF were 1.60 (95% confidence interval: 1.23, 2.09) for trajectory Group 2 and 2.78 (1.93, 4.02) for trajectory Group 3, compared with Group 1. Conclusions Long-term elevated pulse pressure trajectories were independently associated with increased risk of AF in women, but not in men. Our findings call for further investigations to understand the mechanisms behind these sex-based differences.
背景和目的利用1986-2016年基于人群的特罗姆瑟研究(Tromsø Study)的数据,探讨了脉压长期趋势与心房颤动(AF)未来风险之间的性别差异。方法对年龄≥20岁的女性(n = 8331)和男性(n = 7638)进行随访,这些女性(n = 8331)和男性(n = 7638)在1986年至2001年(暴露期)期间至少参加了三次特罗姆瑟研究调查中的两次。脉压≥60mmhg被认为升高。采用分组轨迹模型和Cox回归进行统计分析。结果确定了三个脉压长期轨迹组:1组暴露期脉压正常,2组暴露期开始脉压正常,暴露期结束脉压升高,3组暴露期脉压升高。在随访期间,568名(6.8%)女性和798名(10.5%)男性发生房颤。在基线校正潜在混杂因素后,脉压升高的长期轨迹组与女性房颤风险增加相关,但与男性无关。在女性中,与第1组相比,轨迹组2的调整后AF风险比为1.60(95%可信区间:1.23,2.09),轨迹组3的调整后AF风险比为2.78(1.93,4.02)。结论:长期脉压升高与女性房颤风险增加独立相关,但与男性无关。我们的发现需要进一步的调查来理解这些基于性别的差异背后的机制。
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引用次数: 0
Navigating cardiotoxicity risk in cancer therapy: the importance of the HFA-ICOS score. 在癌症治疗中导航心脏毒性风险:HFA-ICOS评分的重要性。
IF 37.6 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-01-16 DOI: 10.1093/eurheartj/ehae624
Lloyd E Butel-Simoes, Doan T M Ngo, Aaron L Sverdlov
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引用次数: 0
Correction to: Anthracycline-induced cardiovascular toxicity: validation of the Heart Failure Association and International Cardio-Oncology Society risk score. 更正:蒽环类药物诱发的心血管毒性:心力衰竭协会和国际心肿瘤协会风险评分的验证。
IF 37.6 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-01-16 DOI: 10.1093/eurheartj/ehae818
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引用次数: 0
European Research Council-funded grant: development of a novel cardiac tissue model. 欧洲研究理事会资助:开发新型心脏组织模型。
IF 37.6 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-01-16 DOI: 10.1093/eurheartj/ehae740
Gerardina Ruocco, Daniele Testore, Valeria Chiono
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引用次数: 0
Vascular biology and medicine: amyloid-beta alterations in neurocardiovascular diseases and new targets to treat smooth muscle cell dysfunction. 血管生物学和医学:神经心血管疾病中的β淀粉样蛋白改变和治疗平滑肌细胞功能障碍的新靶点。
IF 39.3 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-01-16 DOI: 10.1093/eurheartj/ehae878
Filippo Crea
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引用次数: 0
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European Heart Journal
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