Pub Date : 2026-03-13DOI: 10.1093/eurheartj/ehag139
{"title":"Correction to: Foundation models for electrocardiogram interpretation: clinical implications.","authors":"","doi":"10.1093/eurheartj/ehag139","DOIUrl":"https://doi.org/10.1093/eurheartj/ehag139","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"196 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147439443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-13DOI: 10.1093/eurheartj/ehag086
Toshiyuki Nagai,Toshihisa Anzai,Yoshio Kobayashi
{"title":"ESC Membership Global Award 2025: Japanese Circulation Society.","authors":"Toshiyuki Nagai,Toshihisa Anzai,Yoshio Kobayashi","doi":"10.1093/eurheartj/ehag086","DOIUrl":"https://doi.org/10.1093/eurheartj/ehag086","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"8 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147439663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-13DOI: 10.1093/eurheartj/ehaf519
Sabine Bleiziffer, Florian Leuschner, Tanja K Rudolph, Reinhard Vonthein, Anna L Meyer, Karl Georg Haeusler, Ulrich Hofmann, Armin Gorski, Andreas Hagendorff, Won-Keun Kim, Helmut Baumgartner, Michael A Borger, Yeong-Hoon Choi, Jochen Cremer, Volkmar Falk, Norbert Frey, Christian Hagl, Inke R König, Ulf Landmesser, Steffen Massberg, Hermann Reichenspurner, Matthias Renker, Holger Thiele, Thomas Walther, Andreas Ziegler, Stefan Blankenberg, Henryk Dreger, Rawa Arif, Axel Unbehaun, Moritz Seiffert
Background and aims: Aortic stenosis may be managed differently in women and men, but evidence remains limited. Sex-specific characteristics and outcomes of low- to intermediate-risk patients assigned to transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR) from the DEDICATE-DZHK6 trial are described.
Methods: The DEDICATE-DZHK6 trial demonstrated non-inferiority for the primary outcome of all-cause death or stroke at 1 year. Sex-specific effects were evaluated in this predefined descriptive subgroup analysis.
Results: A total of 1394 patients (43.3% women) were included. Women were older (women: 74.8 ± 4.6 years vs men: 74.2 ± 4.2 years, P = .020) and at higher operative risk [median Society of Thoracic Surgeons risk score 2.1% (1.5-2.7) vs 1.5% (1.0-2.2), P < .001]. All-cause death or stroke at 1 year was 5.2% in the TAVI vs 11.5% in the SAVR group [hazard ratio (HR) 0.46; 95% confidence interval (CI) 0.25-0.82] in women and 5.4% vs 9.0% (HR 0.61; 95% CI 0.35-1.03) in men. At 1 year after TAVI vs SAVR, all-cause death occurred in 2.6% vs 6.7% (HR 0.41; 95% CI 0.17-0.90) in women and 2.6% vs 5.9% (HR 0.44; 95% CI 0.20-0.88) in men. Stroke occurred in 2.6% vs 6.2% (HR 0.43; 95% CI 0.18-0.93) in women and 3.1% vs 3.6% (HR 0.89; 95% CI 0.41-1.90) in men.
Conclusions: Among patients with severe aortic stenosis at low to intermediate risk, TAVI was non-inferior to SAVR for the primary outcome in women and men with lower event rates in patients assigned to TAVI. Women were at particular risk for early complications irrespective of the assigned treatment and at increased stroke risk after SAVR.
背景和目的：男女主动脉瓣狭窄的治疗方法可能不同，但证据仍然有限。本文描述了从dedicated - dzhk6试验中分配到经导管主动脉瓣植入术（TAVI）或手术主动脉瓣置换术（SAVR）的中低风险患者的性别特异性特征和结果。方法：dedicated - dzhk6试验显示1年时全因死亡或卒中的主要结局无劣效性。在这个预定义的描述性亚组分析中评估了性别特异性效应。结果：共纳入1394例患者，其中女性43.3%。女性年龄较大（女性：74.8±4.6岁vs男性：74.2±4.2岁，P = 0.020），手术风险较高[胸外科学会风险评分中位数为2.1% (1.5-2.7)vs 1.5% (1.0-2.2), P < 0.001]。TAVI组1年内全因死亡或卒中发生率为5.2%，而SAVR组为11.5%[危险比（HR） 0.46；95%可信区间（CI） 0.25-0.82]，男性为5.4% vs 9.0% （HR 0.61; 95% CI 0.35-1.03）。TAVI vs SAVR术后1年，女性全因死亡发生率为2.6% vs 6.7% (HR 0.41; 95% CI 0.17-0.90)，男性全因死亡发生率为2.6% vs 5.9% （HR 0.44; 95% CI 0.20-0.88）。女性卒中发生率为2.6% vs 6.2% (HR 0.43; 95% CI 0.18-0.93)，男性卒中发生率为3.1% vs 3.6% （HR 0.89; 95% CI 0.41-1.90）。结论：在低至中危的严重主动脉瓣狭窄患者中，TAVI在女性和男性的主要结局上不低于SAVR， TAVI患者的事件发生率较低。无论指定的治疗方法如何，女性都有特别的早期并发症风险，并且SAVR后卒中风险增加。
{"title":"Sex-specific outcomes after transcatheter or surgical treatment of aortic valve stenosis: the DEDICATE-DZHK6 trial.","authors":"Sabine Bleiziffer, Florian Leuschner, Tanja K Rudolph, Reinhard Vonthein, Anna L Meyer, Karl Georg Haeusler, Ulrich Hofmann, Armin Gorski, Andreas Hagendorff, Won-Keun Kim, Helmut Baumgartner, Michael A Borger, Yeong-Hoon Choi, Jochen Cremer, Volkmar Falk, Norbert Frey, Christian Hagl, Inke R König, Ulf Landmesser, Steffen Massberg, Hermann Reichenspurner, Matthias Renker, Holger Thiele, Thomas Walther, Andreas Ziegler, Stefan Blankenberg, Henryk Dreger, Rawa Arif, Axel Unbehaun, Moritz Seiffert","doi":"10.1093/eurheartj/ehaf519","DOIUrl":"10.1093/eurheartj/ehaf519","url":null,"abstract":"<p><strong>Background and aims: </strong>Aortic stenosis may be managed differently in women and men, but evidence remains limited. Sex-specific characteristics and outcomes of low- to intermediate-risk patients assigned to transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR) from the DEDICATE-DZHK6 trial are described.</p><p><strong>Methods: </strong>The DEDICATE-DZHK6 trial demonstrated non-inferiority for the primary outcome of all-cause death or stroke at 1 year. Sex-specific effects were evaluated in this predefined descriptive subgroup analysis.</p><p><strong>Results: </strong>A total of 1394 patients (43.3% women) were included. Women were older (women: 74.8 ± 4.6 years vs men: 74.2 ± 4.2 years, P = .020) and at higher operative risk [median Society of Thoracic Surgeons risk score 2.1% (1.5-2.7) vs 1.5% (1.0-2.2), P < .001]. All-cause death or stroke at 1 year was 5.2% in the TAVI vs 11.5% in the SAVR group [hazard ratio (HR) 0.46; 95% confidence interval (CI) 0.25-0.82] in women and 5.4% vs 9.0% (HR 0.61; 95% CI 0.35-1.03) in men. At 1 year after TAVI vs SAVR, all-cause death occurred in 2.6% vs 6.7% (HR 0.41; 95% CI 0.17-0.90) in women and 2.6% vs 5.9% (HR 0.44; 95% CI 0.20-0.88) in men. Stroke occurred in 2.6% vs 6.2% (HR 0.43; 95% CI 0.18-0.93) in women and 3.1% vs 3.6% (HR 0.89; 95% CI 0.41-1.90) in men.</p><p><strong>Conclusions: </strong>Among patients with severe aortic stenosis at low to intermediate risk, TAVI was non-inferior to SAVR for the primary outcome in women and men with lower event rates in patients assigned to TAVI. Women were at particular risk for early complications irrespective of the assigned treatment and at increased stroke risk after SAVR.</p>","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"1339-1353"},"PeriodicalIF":35.6,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-13DOI: 10.1093/eurheartj/ehag094
Anna Sonia Petronio,Victoria Delgado,Fabien Praz
{"title":"The ESC Council on Valvular Heart Disease today and the vision for tomorrow.","authors":"Anna Sonia Petronio,Victoria Delgado,Fabien Praz","doi":"10.1093/eurheartj/ehag094","DOIUrl":"https://doi.org/10.1093/eurheartj/ehag094","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"56 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147439658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-13DOI: 10.1093/eurheartj/ehag001
Sadananda Bolar Naik
{"title":"The human side of a legendary cardiologist.","authors":"Sadananda Bolar Naik","doi":"10.1093/eurheartj/ehag001","DOIUrl":"10.1093/eurheartj/ehag001","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"1276"},"PeriodicalIF":35.6,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146124192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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