European Heart Journal最新文献

{"title":"European Research Council starting grant: ultrafast ultrasound imaging for genotype-phenotype interplay in hypertrophic cardiomyopathy.","authors":"Olivier Villemain","doi":"10.1093/eurheartj/ehaf1041","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf1041","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":35.6,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2025 ESC gold medallist: Ulrich Sigwart.","authors":"Judith Ozkan","doi":"10.1093/eurheartj/ehaf977","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf977","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":35.6,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The endogenous cardiac cholinergic system: a robust and independent regulator of ventricular conduction.","authors":"Duanyang Xie, Dandan Liang, Yi-Han Chen","doi":"10.1093/eurheartj/ehaf1109","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf1109","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":35.6,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anomalous origin of right vertebral artery.","authors":"Liying Ma, Zhang Cheng, Yiqi Jin","doi":"10.1093/eurheartj/ehaf1069","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf1069","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":35.6,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital heartbeat: wearables for early detection and integrated management of atrial fibrillation.","authors":"Nicole Lowres, Jessica J Orchard, Ben Freedman","doi":"10.1093/eurheartj/ehaf998","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf998","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":35.6,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival prospects of women with peripartum cardiomyopathy in Tanzania: a prospective cohort study","authors":"P Pallangyo, Z S Mkojera, M S Komba, L N Mfanga","doi":"10.1093/eurheartj/ehaf784.1134","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf784.1134","url":null,"abstract":"Background Peripartum cardiomyopathy (PPCM) is a leading cause of non-obstetric feto-maternal morbidity and mortality worldwide, despite a higher recovery rate compared to other forms of systolic heart failure. This study assessed PPCM survival outcomes in Tanzania. Methods A prospective, multicenter study began in April 2016, enrolling 1210 women meeting PPCM criteria. Clinical data were collected at baseline and at 3-, 6-, and 12-month follow-ups. Outcomes included complete recovery (LVEF >55%), persistent dysfunction, and death. Cox regression analysis identified predictors of mortality. Results Among 1386 women (mean age: 29.4 ± 6.7 years), 23.6% achieved complete recovery, 48.2% had persistent dysfunction, and 28.1% died during a mean follow-up of 889 days. Of 870 survivors, 121 had subsequent pregnancies, with 51.3% experiencing PPCM recurrence, 31.4% recovering, and 8.3% dying. Predictors of mortality included atrial fibrillation (HR 5.0), LVIDd ≥60 (HR 2.8), EF <30% (HR 1.7), TAPSE <14 (HR 7.4), and LV thrombus (HR 2.3). Conclusions PPCM poses significant diagnostic, prognostic, and treatment challenges, with high rates of persistent dysfunction and mortality despite recovery prospects.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"393 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145920504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital heart defects: familial recurrence patterns in Sweden.","authors":"Kalliopi Kazamia, Sara Ekberg, Caroline E Dietrich, Håkan Eliasson, Marie Wahren-Herlenius, Gunnar Bergman","doi":"10.1093/eurheartj/ehaf1048","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf1048","url":null,"abstract":"<p><strong>Background and aims: </strong>Congenital heart defects (CHD) aggregate in families, but recurrence patterns across kinships and generations remain incompletely understood. In light of improved survival and diagnostic precision, updated population-based estimates are needed. This study aimed to investigate familial recurrence patterns of CHD among relatives using nationwide Swedish register data.</p><p><strong>Methods: </strong>A retrospective, population-based case-control study was conducted, including 51 778 individuals with CHD born between 1987 and 2017 and 522 543 matched controls. Relatives (parents, full siblings, half-siblings, and offspring) were identified through linkage to national health and population registers. Logistic regression with robust standard errors clustered on maternal ID was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Dose-response relationships, kinship-specific associations, and interactions with maternal comorbidities (diabetes, hypertension, and obesity) were explored.</p><p><strong>Results: </strong>Among individuals with at least one affected relative, the OR for CHD was 2.71 (95% CI 2.60-2.83), increasing with each additional affected relative (OR per relative 2.55; 95% CI 2.46-2.64). Recurrence was strongest for mothers (OR 3.12), full siblings (OR 3.22), and offspring (OR 3.18) and lower for fathers and half-siblings. A dose-response was observed by number of affected siblings and offspring. The association between maternal CHD and CHD in index individuals was not explained by maternal comorbidities.</p><p><strong>Conclusions: </strong>Congenital heart defect in a relative (parent, full or half-siblings, or offspring) is associated with CHD in the index individual, with recurrence patterns varying by kinship and number of affected relatives. These findings may inform genetic counselling and reproductive planning.</p>","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":35.6,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update from ESC council on hypertension.","authors":"Isabella Sudano, Gianfranco Parati, Eva Gerdts","doi":"10.1093/eurheartj/ehaf976","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf976","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":35.6,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy and safety of tenecteplase versus alteplase in patients with myocardial infarction: a systematic review","authors":"A Zahin, A Nourin Mou, R Roy, M D Fahad Hossain, Z Shahriar, T Naima, S Noushin Hossain","doi":"10.1093/eurheartj/ehaf784.2084","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf784.2084","url":null,"abstract":"Background 83% of the world population residing in the developing countries has insufficient access to Percutaneous Coronary Intervention (PCI) for Myocardial Infarction. Tenecteplase and Alteplase being the two most widely used alternatives to PCI lacks concrete evidence in their comparison in the form of a systematic review to guide their use in clinical practice for the best outcome. Purpose Our study critically analyzed all the available Randomized Control Trials within the prospectively declared eligibility criteria to produce evidence for clinical decision making while administering Tenecteplase and Alteplase in Myocardial Infarction. Method The study was conducted following PRISMA guideline. PubMed, Scopus, Cochrane Library, Web of Science and EBSCOhost were searched for Randomized Control Trials from inception to 25 June 2024 without using any filters. The International Prospective Register of Systematic Reviews was used to register the protocol of this review prospectively. All-cause mortality, hemorrhage and other bleeding complications were used to assess efficacy and safety. The studies involving patients at and above 18 years were included. Two independent investigators have performed literature searches, inclusion and data extraction. Disagreements were solved by mutual discussion. Duplicate articles were removed and inclusion-exclusion were done using Rayyan software. Results Our study included 5 studies that enrolled a total of 18,033 patients. Tenecteplase has been found to have better efficacy than alteplase particularly in its action on older infarcts and in the rapidity of recanalization. Four studies that reported safety showed lower rates of Intracerebral Hemorrhage and Major bleeding disorders in case of Tenecteplase in comparison to Alteplase. Older (&gt; 75 years) and low weight (&lt;67 kg) females showed significantly lower rates of major bleeding events with Tenecteplase (8.33%) than Alteplase (15.15%). Conclusion Our study demonstrates Tenecteplase to be more efficacious and safer than Alteplase suggesting the use of Tenecteplase in clinical practice. However, it also raises the question of age-sex-ethnicity-bodyweight variability on the efficacy and safety of these two drugs suggesting Randomized Control Trials to answer this question. <jats:fig fig-type=\"figure\" position=\"anchor\"> <jats:caption> Graphical </jats:caption> <jats:graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" mimetype=\"image\" position=\"anchor\" xlink:href=\"33592420250126190945_1.jpg\"/> </jats:fig> <jats:fig fig-type=\"figure\" position=\"anchor\"> <jats:caption> Methodology </jats:caption> <jats:graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" mimetype=\"image\" position=\"anchor\" xlink:href=\"33592420250126190359_2.jpg\"/> </jats:fig>","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"30 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145920327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspirin's echo: rebound, delay, or statistical mirage? Re-examining legacy cardiovascular risk after cessation.","authors":"Hongxuan Fan, Boda Zhou","doi":"10.1093/eurheartj/ehaf905","DOIUrl":"10.1093/eurheartj/ehaf905","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"273"},"PeriodicalIF":35.6,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145539488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}