European Journal of Neuroscience最新文献

Hu, Y., Y. Zhu, X. Wen, F. Zeng, Y. Feng, Z. Xu, F. Xu, and J. Wang. 2022. “ Repetitive Transcranial Magnetic Stimulation Regulates Neuroinflammation, Relieves Hyperalgesia and Reverses Despair-Like Chronic Constriction Injury Rats.” European Journal of Neuroscience 56, no. 6: 4930–4947. https://doi.org/10.1111/ejn.15779.

In the paper by Hu et al. (2022), there was an error in Table 2, where the western blot data presented were mistakenly derived from a different experiment conducted by the group. The correct western blot data were included in Figure 2C, and these accurately represent the findings for this study.

The correct Table 2 appears below:

This error does not affect the results, interpretations or conclusions of the study.

We apologize for this error.

Ineffective reperfusion remains a critical challenge in neurointerventional treatment following ischemic stroke, with the integrity of the blood–brain barrier (BBB) being a key determinant of patient outcomes. This review explores the distinctive characteristics and roles of brain endothelial cells (ECs) in the context of stroke and ineffective reperfusion. We examine the unique properties of brain ECs compared to their counterparts in other tissues, focusing on their pathophysiological changes, functional impairments and the inflammatory cascades that follow stroke. Differences in gene expression between brain ECs and those in other organs offer deeper insights into their role in neuroprotective therapies. Additionally, drawing parallels between brain ECs and ECs from organs with similar ischemia–reperfusion injury profiles may inspire novel therapeutic approaches. This review highlights the critical importance of understanding the nuanced roles of ECs in BBB regulation, which ultimately impacts reperfusion outcomes.

Combining multisensory cues is fundamental for perception and action and reflected by two frequently studied phenomena: multisensory integration and sensory recalibration. In the context of audio-visual spatial signals, these phenomena are exemplified by the ventriloquism effect and its aftereffect. The ventriloquism effect occurs when the perceived location of a sound is biased by a concurrent visual stimulus, while the aftereffect manifests as a recalibration of perceived sound location after exposure to spatially discrepant stimuli. The relationship between these processes—whether recalibration is a direct consequence of integration or operates independently—remains debated. We investigate the role of causal inference in these processes by examining whether trial-wise judgements about a common-cause underlying audio-visual stimuli influence both the ventriloquism effect and the immediate aftereffect. In a spatial paradigm, participants made explicit judgements about the common cause of stimulus pairs, and their influence on both perceptual biases was assessed. Results obtained across two experiments indicate that while multisensory integration is contingent on common cause judgements, the immediate recalibration effect is not. This suggests that recalibration can occur independently of the perceived commonality of the multisensory stimuli, challenging the notion that recalibration is solely a by-product of integration.

Long-term potentiation (LTP)-like plasticity in primary motor cortex (M1) induced by intermittent theta burst stimulation (iTBS) can be enhanced by transcranial alternating current stimulation (tACS) at a gamma frequency of 70 Hz. Recent evidence suggests that there is some frequency specificity in the effects of tACS on motor function within the midgamma band (60–90 Hz). The purpose of this study was to examine the effect of different tACS frequencies within the gamma band on the neuroplastic response to iTBS. Seventeen healthy young adults performed four experimental sessions, where iTBS was combined with different tACS conditions (60, 75 and 90 Hz, sham) over M1 using a tACS-iTBS costimulation approach. Motor evoked potential (MEP) amplitude and short-interval intracortical inhibition (SICI) were assessed from a hand muscle before and after the intervention using transcranial magnetic stimulation with posterior–anterior (PA) and anterior–posterior (AP) coil orientations. Gamma tACS-iTBS costimulation increased PA and AP MEPs when gamma tACS was applied at 90 Hz, but not at 75 or 60 Hz, compared with sham tACS. PA and AP SICI was reduced by tACS-iTBS costimulation, but this was not influenced by gamma tACS frequency. Gamma tACS can increase LTP-like plasticity when combined with iTBS over M1, with the largest effect observed when tACS was applied at higher gamma frequencies. The functional relevance of targeting higher gamma frequencies within different brain areas and study populations remains to be determined.

Working memory, which tends to be the most vulnerable cognitive domain to aging, is thought to depend on a functional brain network for efficient communication. The dynamic communication within this network is represented by segregation and integration. This study aimed to investigate healthy aging by examining age effect on outcomes of graph theory analysis during the visual short-term memory binding (VSTMB) task. VSTMB tasks rely on the integration of visual features and are less sensitive to semantic and verbal strategies. Effects of age on neuropsychological test scores, along with the EEG graph-theoretical integration, segregation and global organization metrics in frequencies from delta to gamma band were investigated. Neuropsychological assessment showed low sensitivity as a measure of age-related changes. EEG results indicated that network architecture changed more effectively during middle age, while this effectiveness appears to vanish or show compensatory mechanisms in the elderly. These differences were further found to be related to cognitive domain scores. This study is the first to demonstrate differences in working memory network architecture across a broad age range.

Song, M. R., and S. W. Lee. 2024. “ Rethinking Dopamine-Guided Action Sequence Learning.” European Journal of Neuroscience 60, no. 1: 3447–3465. https://doi.org/10.1111/ejn.16426.

In the paper by Song and Lee (2024), the grant number regarding the funding from the Electronics and Telecommunications Research Institute (ETRI) was incorrect. The funding agency requested to update the grant number from 24ZS1100 to 24ZB1100.

We apologize for this error.

Decision making is an integral part of everyday life. Recently, there has been a growing interest in the potential influence of action on perceptual decisions, following ideas of embodied decision making. Studies examining decisions regarding the direction of noisy visual motion have found a bias towards the least effortful response option in experiments in which the differences in motor costs associated with alternative response actions were implicit, but not in an experiment in which these differences were made explicit. It remains unclear whether the biasing effect generalizes to other perceptual tasks than motion perception and whether consciously experiencing motor costs prevents such biases. To test the generalizability of effects across perceptual tasks, we used a within-subjects design where 24 participants performed both a motion discrimination task and an orientation discrimination task. Motor costs were manipulated by presenting response buttons for the two alternative choices at different reaching distances. By varying distances randomly, we avoided implicit biases linked to specific decisions. Our findings revealed a bias towards closer response options in both tasks, indicating that explicit information of motor costs significantly impacts perceptual decisions beyond motion discrimination. Contrary to prevailing theories that consider the motor system as a mere effector of the decision, our study implies that the actions that are associated with the response options influence the decision process itself.