European Journal of Psychiatry最新文献_第3页

Features of Spanish non-commercial non-pharmacological completed clinical trials in psychiatry 西班牙非商业非药理完成精神病学临床试验的特点

IF 1.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-10-01 DOI: 10.1016/j.ejpsy.2025.100330

Rafael Dal-Ré , Elena García-Méndez , Ignacio Mahillo-Fernández

引用次数: 0

Psychometric validation of the self-administered French version of the Functioning Assessment Short Test (FAST): Factor structure, reliability, validity, and sociodemographic predictors 自我管理法语版功能评估短测验（FAST）的心理计量学验证：因素结构、信度、效度和社会人口预测因子

IF 1.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-09-26 DOI: 10.1016/j.ejpsy.2025.100325

Audrey Uyttersprot , Nellia Bellaert , Eduard Vieta , Sandra Invernizzi , Laurence Ris , Laurent Lefebvre

Background and objectives

The Functioning Assessment Short Test (FAST) is widely used to assess psychosocial functioning across psychiatric conditions. Despite extensive international validation, a validated French version of the self-administered FAST is currently lacking. This study aimed to evaluate the psychometric properties of the self-administered French FAST in a general adult population.

Methods

A total of 508 French-speaking adults aged 18–65 completed the FAST alongside standardized measures of depression and anxiety. Exploratory and confirmatory factor analyses and bifactor modeling evaluated the original six-factor structure. Reliability was assessed using Cronbach’s alpha and McDonald’s omega. Convergent validity was evaluated through multitrait-multimethod (MTMM) analysis and correlations with depression and anxiety. Generalized additive models (GAMs) examined non-linear associations between symptom severity and FAST scores, controlling for demographic covariates.

Results

The original six-factor structure was confirmed, and the bifactor model further supported interpretation of both total and subscale scores. Reliability was strong for the total FAST score (α = .86; ω = .90), whereas subscale reliability (α = .58–.80), with lower values for autonomy, cognitive, and leisure. MTMM analysis demonstrated moderate-to-high monotrait correlations (.51–.84), and moderate correlations with depressive (r = .46) and anxiety (r = .35) symptoms, supporting convergent validity. GAM analyses revealed a non-linear relationship between depressive symptoms and psychosocial impairment (edf = 2.91, F = 19.87, p < .001), alongside significant effects of anxiety (p = .024) and employment status (p = .003).

Conclusions

The French self-administered FAST demonstrates robust psychometric properties and appears suitable for assessing psychosocial functioning in general adult populations, though caution is advised when interpreting autonomy, cognitive, and leisure subscales in non-clinical samples until further clinical validation is available.

背景和目的功能评估短测试（FAST）被广泛用于评估精神疾病的社会心理功能。尽管得到了广泛的国际认可，但目前还缺乏经过验证的法语版自我管理FAST。本研究旨在评估一般成年人自我管理的法语FAST的心理测量特性。方法共有508名年龄在18-65岁的法语成年人完成了FAST，并进行了标准化的抑郁和焦虑测量。探索性和验证性因子分析和双因子模型评估了原来的六因子结构。采用Cronbach 's alpha和McDonald 's omega评估信度。通过多特质-多方法（MTMM）分析评估收敛效度，并与抑郁和焦虑进行相关性分析。广义加性模型（GAMs）检验了症状严重程度和FAST评分之间的非线性关联，控制了人口统计学协变量。结果原来的六因子结构得到证实，双因子模型进一步支持总分和分量表得分的解释。FAST总分的信度较高（α = 0.86; ω = 0.90），而次量表的信度较高（α = 0.58 - 0.90）。80)，自主性、认知和休闲的价值较低。MTMM分析显示了中至高的单性状相关性（0.51 -）。84)，并且与抑郁（r = 0.46）和焦虑（r = 0.35）症状有中度相关性，支持收敛效度。GAM分析显示，抑郁症状与心理社会障碍之间存在非线性关系（edf = 2.91, F = 19.87, p < .001），焦虑（p = 0.024）和就业状况（p = 0.003）也有显著影响。结论：法国自我管理的FAST显示出强大的心理测量特性，似乎适用于评估一般成年人的社会心理功能，尽管在解释非临床样本的自主性、认知和休闲亚量表时建议谨慎，直到进一步的临床验证可用。

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引用次数: 0

Spanish validation of “The Awareness of Social Inference Test” (TASIT) “社会推理意识测试”（TASIT）的西班牙语验证

IF 1.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-09-16 DOI: 10.1016/j.ejpsy.2025.100324

Lorena García-Fernández , Nuria Cabot Iborra , Verónica Romero-Ferreiro , Miguel A. Álvarez-Mon , Estela Jiménez López , Guillermo Lahera , Skye McDonald , Roberto Rodriguez-Jimenez

Background and objectives

Social cognition (SC) plays a fundamental role in interpersonal functioning and is often impaired in severe mental disorders like schizophrenia. The Awareness of Social Inference Test (TASIT) is a reliable tool for assessing SC through audiovisual vignettes, but a validated Spanish version was lacking. This study aimed to translate, adapt, and validate TASIT for Spanish-speaking populations.

Method

A cross-sectional study was conducted with 659 participants, including healthy individuals and people with schizophrenia. The TASIT was translated and adapted following a rigorous procedure with the participation and guidance of the original author. Reliability, convergent, and discriminant validity were assessed using established psychometric tools.

Results

The Spanish version of TASIT demonstrated strong internal consistency across all sections, with McDonald’s omega coefficients ranging from ω = 0.71 to 0.89. Test-retest reliability was excellent, with correlation coefficients ranging from r = 0.81 to 0.87 (all p < .001). Convergent validity was supported by significant correlations with established social cognition measures (p < .05), and discriminant validity was confirmed by significant performance differences between healthy participants and those with schizophrenia (p < .05).

Conclusions

The Spanish TASIT is a valid and reliable tool for assessing SC, with strong psychometric properties. It is suitable for both clinical and research settings.

背景与目的社会认知（SC）在人际关系中起着重要作用，在精神分裂症等严重精神障碍中经常受损。社会推理意识测试（TASIT）是一种可靠的工具，通过视听小插曲评估SC，但缺乏有效的西班牙语版本。本研究旨在为西班牙语人群翻译、调整和验证TASIT。方法对659名健康个体和精神分裂症患者进行横断面研究。在原作者的参与和指导下，按照严格的程序进行了翻译和改编。采用已建立的心理测量工具评估信度、收敛效度和判别效度。结果西班牙语版本的TASIT在所有部分表现出很强的内部一致性，麦当劳的ω系数范围为ω = 0.71至0.89。重测信度极好，相关系数r = 0.81 ~ 0.87（均p <； .001）。与已建立的社会认知测量的显著相关性支持了收敛效度（p < 0.05），健康参与者和精神分裂症患者之间的显著表现差异证实了区别效度（p < 0.05）。结论西班牙语TASIT量表具有较强的心理测量特性，是一种有效、可靠的SC评估工具。它适用于临床和研究设置。

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引用次数: 0

Telehealth group parent training for children with autism spectrum disorder and behavioral difficulties: feasibility, acceptability and preliminary efficacy 远程医疗团体家长训练对自闭症谱系障碍和行为困难儿童的可行性、可接受性和初步效果

IF 1.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-08-22 DOI: 10.1016/j.ejpsy.2025.100319

Imanol Setien-Ramos , Teresa Alonzo-Castillo , Aina García-Martínez , Jorge Lugo-Marín , María Martínez-Ramírez , Josep Antoni Ramos-Quiroga , Laura Gisbert-Gustemps

Background and objectives

Children with Autism Spectrum Disorder (ASD) frequently experience significant behavioral challenges that hinder adaptive functioning and increase caregiver stress. This study assesses the feasibility, acceptability, and preliminary efficacy of a telehealth-delivered group parent training program designed to address behavioral difficulties in children with ASD.

Method

An open-label, single-arm trial was conducted with children aged 3–12 years diagnosed with ASD and behavioral difficulties, recruited from a tertiary hospital’s autism care program. Program effectiveness was evaluated using parent-reported measures on their children and on themselves assessing behavior problems, parental stress, and quality of life. Data analysis included pre-post comparisons and follow-up assessments at 3 and 6 months.

Results

Twenty dyads parent-children were analyzed. Satisfaction with the program was moderate, with especially favorable feedback on the "planned ignoring" unit. Preferences for delivery mode and format varied, with suggestions to reduce the number of tasks and tailor content to individual needs. Significant reductions in irritability, lethargy, hyperactivity were observed immediately after treatment, with improvements in irritability and hyperactivity sustained at the 3- and 6-month follow-ups. Parental stress decreased significantly post-treatment but did not persist over time. Quality of life improved significantly compared to baseline, both immediately post-treatment and during follow-up evaluations.

Conclusions

The telehealth-delivered group parent training program demonstrated feasibility and moderate acceptability, with significant improvements in child behavior and caregiver quality of life. However, the reduction in parental stress was not sustained over time. These findings underscore the potential of telehealth-delivered group interventions for managing ASD-related behavioral issues and indicate areas for program refinement to enhance adherence and long-term effectiveness.

背景和目的自闭症谱系障碍（ASD）儿童经常经历严重的行为挑战，这些挑战阻碍了适应功能并增加了照顾者的压力。本研究评估了远程医疗提供的小组家长培训计划的可行性、可接受性和初步效果，该计划旨在解决自闭症儿童的行为困难。方法进行一项开放标签单臂试验，从一家三级医院的自闭症护理项目中招募3-12岁被诊断为ASD和行为困难的儿童。通过父母对孩子和他们自己的行为问题、父母压力和生活质量的评估来评估项目的有效性。数据分析包括前后比较和3个月和6个月的随访评估。结果对20对父子进行了分析。对该计划的满意度是中等的，对“计划忽视”单元的反馈尤其有利。对于交付模式和格式的偏好各不相同，建议减少任务数量并根据个人需求定制内容。治疗后立即观察到易怒、嗜睡、多动明显减少，在3个月和6个月的随访中，易怒和多动持续改善。父母的压力在治疗后显著减少，但没有持续一段时间。治疗后和随访期间的生活质量与基线相比均有显著改善。结论远程医疗团体家长培训项目具有可行性和可接受性，在儿童行为和照顾者生活质量方面有显著改善。然而，父母压力的减少并没有随着时间的推移而持续。这些发现强调了远程医疗提供的群体干预在管理自闭症相关行为问题方面的潜力，并指出了改进项目的领域，以提高依从性和长期有效性。

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引用次数: 0

The association of α-klotho/fibroblast growth factor 23 with cognitive features in euthymic older age patients with bipolar disorder α-klotho/成纤维细胞生长因子23与老年健康双相障碍患者认知特征的关系

IF 1.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-08-21 DOI: 10.1016/j.ejpsy.2025.100320

Wen-Yin Chen , Chih Chiang Chiu , Po-Hsiu Kuo , Cho-Yin Huang , Shang-Ying Tsia , Chian-Jue Kuo , Ying-Chih Cheng , Po-Yu Chen , Ming-Chyi Huang

Background and objectives

Cognitive aging is common among bipolar disorder (BD). The α-klotho/fibroblast growth factor 23 (FGF23) system has been associated with neuropsychiatric disorders and age-related diseases. This study aimed to investigate α-klotho and FGF23 levels in older-age bipolar disorder (OABD) and examine their associations with aging-related characteristics and cognitive function.

Methods

This study included 87 euthymic OABD, 83 younger-age bipolar disorder (YABD), and 20 healthy controls, to assess α-klotho and FGF23 levels. In OABD group, cognitive function was evaluated using the Brief Assessment of Cognition in Affective Disorders. Aging-related features were assessed, including daily physical activity, grip strength, and the Framingham Risk Score. We examined the correlations between α-klotho/FGF23 levels and aging-related features and explored their associations with cognitive domains in OABD.

Results

The FGF23 levels in OABD were lower compared to those in YABD. The α-klotho levels were not significantly different between three groups. A negative association was observed between FGF23 and global cognitive composite scores (B = -0.006, p = 0.005), particularly in motor speed (B = -0.006, p = 0.001), working memory (B = -0.007, p = 0.006), and verbal fluency (B = -0.002, p = 0.049). Additionally, α-klotho levels were positively associated with working memory (B = 0.735, p = 0.039).

Conclusions

FGF23 had a negative impact on cognitive domains, while α-klotho was positively associated with working memory in OABD. Future research should investigate the dysfunction of the α-klotho/FGF23 axis and incorporate additional validated aging markers in longitudinal studies to confirm the proposed biomarker relationships.

背景与目的认知衰老在双相情感障碍（BD）中很常见。α-klotho/成纤维细胞生长因子23 （FGF23）系统与神经精神疾病和年龄相关疾病有关。本研究旨在探讨老年双相情感障碍（OABD）患者α-klotho和FGF23水平，并探讨其与衰老相关特征和认知功能的关系。方法本研究纳入87例正常心境型OABD、83例年轻型双相情感障碍（YABD）和20例健康对照，评估α-klotho和FGF23水平。在OABD组，认知功能评估使用情感障碍认知简要评估。评估了与衰老相关的特征，包括日常体力活动、握力和Framingham风险评分。我们检测了α-klotho/FGF23水平与衰老相关特征的相关性，并探讨了它们与OABD认知领域的关系。结果OABD组FGF23水平低于YABD组。各组间α-klotho水平差异无统计学意义。FGF23与整体认知综合得分呈负相关（B = -0.006, p = 0.005），特别是在运动速度（B = -0.006, p = 0.001）、工作记忆（B = -0.007, p = 0.006）和语言流畅性（B = -0.002, p = 0.049）方面。α-klotho水平与工作记忆呈正相关（B = 0.735, p = 0.039）。结论sfgf23对OABD患者的认知功能域有负向影响，而α-klotho对OABD患者的工作记忆功能域有正向影响。未来的研究应该研究α-klotho/FGF23轴的功能障碍，并在纵向研究中纳入其他经过验证的衰老标志物，以证实所提出的生物标志物关系。

{"title":"The association of α-klotho/fibroblast growth factor 23 with cognitive features in euthymic older age patients with bipolar disorder","authors":"Wen-Yin Chen , Chih Chiang Chiu , Po-Hsiu Kuo , Cho-Yin Huang , Shang-Ying Tsia , Chian-Jue Kuo , Ying-Chih Cheng , Po-Yu Chen , Ming-Chyi Huang","doi":"10.1016/j.ejpsy.2025.100320","DOIUrl":"10.1016/j.ejpsy.2025.100320","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Cognitive aging is common among bipolar disorder (BD). The α-klotho/fibroblast growth factor 23 (FGF23) system has been associated with neuropsychiatric disorders and age-related diseases. This study aimed to investigate α-klotho and FGF23 levels in older-age bipolar disorder (OABD) and examine their associations with aging-related characteristics and cognitive function.</div></div><div><h3>Methods</h3><div>This study included 87 euthymic OABD, 83 younger-age bipolar disorder (YABD), and 20 healthy controls, to assess α-klotho and FGF23 levels. In OABD group, cognitive function was evaluated using the Brief Assessment of Cognition in Affective Disorders. Aging-related features were assessed, including daily physical activity, grip strength, and the Framingham Risk Score. We examined the correlations between α-klotho/FGF23 levels and aging-related features and explored their associations with cognitive domains in OABD.</div></div><div><h3>Results</h3><div>The FGF23 levels in OABD were lower compared to those in YABD. The α-klotho levels were not significantly different between three groups. A negative association was observed between FGF23 and global cognitive composite scores (<em>B</em> = -0.006, <em>p</em> = 0.005), particularly in motor speed (<em>B</em> = -0.006, <em>p</em> = 0.001), working memory (<em>B</em> = -0.007, <em>p</em> = 0.006), and verbal fluency (<em>B</em> = -0.002, <em>p</em> = 0.049). Additionally, α-klotho levels were positively associated with working memory (<em>B</em> = 0.735, <em>p</em> = 0.039).</div></div><div><h3>Conclusions</h3><div>FGF23 had a negative impact on cognitive domains, while α-klotho was positively associated with working memory in OABD. Future research should investigate the dysfunction of the α-klotho/FGF23 axis and incorporate additional validated aging markers in longitudinal studies to confirm the proposed biomarker relationships.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 4","pages":"Article 100320"},"PeriodicalIF":1.5,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144886654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional brain imaging of negative symptoms in schizophrenia: further evidence of prefrontal dysfunction 精神分裂症阴性症状的功能性脑成像：前额叶功能障碍的进一步证据

IF 1.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-08-21 DOI: 10.1016/j.ejpsy.2025.100322

Paola Fuentes-Claramonte , Ana Aquino-Servín , María Ángeles Garcia-León , Jordi Ortiz-Gil , Pilar Salgado-Pineda , Amalia Guerrero-Pedraza , Salvador Sarró , Emilio J. Inarejos-Clemente , Raymond Salvador , Peter J. McKenna , Edith Pomarol-Clotet

Background and objectives

An influential theory of negative symptoms in schizophrenia is that they are due to frontal lobe dysfunction, although this has not been consistently supported by functional imaging studies to date. Recently, our group found evidence of an association between negative symptoms and prefrontal hypoactivation during a novel executive task sensitive to goal neglect. The present study sought to extend this finding using a different functional imaging paradigm, the n-back working memory task.

Methods

Ninety-six medicated patients with schizophrenia were divided according to the Positive and Negative Symptoms Scale (PANSS) scores into groups with high negative symptom scores (HNS, N=70, negative symptom score range 15-34), and with low negative symptom scores (LNS, N=26, negative symptom score range 6-14). Along with 50 matched healthy controls, they underwent fMRI while performing the 2-back and 1-back versions of the n-back task.

Results

In the 2-back vs 1-back comparison, working memory-related activation was observed in lateral prefrontal and inferior parietal areas in all groups. The HNS patients, but not the LNS patients showed reduced activation in these task-related regions compared to the healthy controls. The HNS patients also showed hypoactivation in the right dorsolateral prefrontal cortex relative to the LNS patients, although this finding was no longer statistically significant when disorganization scores were added as a covariate.

Conclusion

Our results provide further evidence supporting the prefrontal hypothesis of negative symptoms, but also highlight the potential role of disorganization in modulating prefrontal activity.

背景和目的精神分裂症阴性症状的一个有影响力的理论是由于额叶功能障碍，尽管迄今为止尚未得到功能影像学研究的一致支持。最近，我们的小组发现了在一个对目标忽视敏感的新执行任务中，消极症状和前额叶失活之间存在关联的证据。本研究试图使用不同的功能成像范式，即n-back工作记忆任务来扩展这一发现。方法将96例精神分裂症服药患者按阳性症状和阴性症状量表（PANSS）评分分为高阴性症状组（HNS， N=70，阴性症状评分范围15 ~ 34）和低阴性症状组（LNS， N=26，阴性症状评分范围6 ~ 14）。与50名匹配的健康对照者一起，他们在执行n-back任务的2-back和1-back版本时接受了功能磁共振成像。结果2-back与1-back比较，两组的前额外侧区和下顶叶区均有工作记忆相关的激活。与健康对照相比，HNS患者在这些任务相关区域的激活减少，而LNS患者则没有。与LNS患者相比，HNS患者的右侧背外侧前额叶皮层也表现出低激活，尽管当将无序性评分作为协变量添加时，这一发现不再具有统计学意义。结论本研究结果进一步支持了消极症状的前额叶假说，同时也强调了紊乱在调节前额叶活动中的潜在作用。

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引用次数: 0

Self-efficacy for coping with cancer among cancer survivors with preexisting mental health conditions versus a control group 先前存在心理健康问题的癌症幸存者与对照组之间应对癌症的自我效能感

IF 2.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-07-25 DOI: 10.1016/j.ejpsy.2025.100318

Miri Cohen , Marc Gelkopf

Background and objectives

Self-efficacy for coping with cancer is a significant factor for cancer survivors’ quality of life, but it has not been examined among individuals with preexisting severe mental health conditions (SMHC). This study compared perceptions of self-efficacy for coping with cancer among cancer survivors with and without precancer SMHC; quality of communication with the oncology team and depressive symptoms as antecedents of self-efficacy; and the mediating role of self-regulation (cognitive reappraisal and expressive suppression) between antecedents and perceived self-efficacy for coping with cancer.

Methods

Participants were 170 adult cancer survivors with preexisting SMHC and 80 with no SMHC, aged 20–71, and 1–5 years since diagnosis. They filled out questionnaires in a face-to-face meeting. Multigroup path analysis was conducted using structural equation modeling.

Results

Individuals with SMHC reported lower self-efficacy for coping with cancer and higher levels of depressive symptoms. In the SMHC group, cognitive reappraisal mediated the association between perceived communication quality and self-efficacy, and expressive suppression mediated the relationship between depressive symptoms and self-efficacy.

Conclusions

The results highlight the deficiency in self-efficacy for coping with cancer in individuals with SMHC, a prominent factor for treatment adherence and quality of life among cancer survivors. Findings suggest self-efficacy may be strengthened via more emphatic and attentive communication with the oncology team and fostering effective emotion regulation strategies.

背景与目的应对癌症的自我效能感是影响癌症幸存者生活质量的一个重要因素，但尚未在患有严重精神健康状况（SMHC）的个体中进行研究。本研究比较了有和没有癌前SMHC的癌症幸存者应对癌症的自我效能感；与肿瘤团队的沟通质量和抑郁症状作为自我效能感的先决条件；自我调节（认知重评和表达抑制）在应对癌症的前因由和感知自我效能之间的中介作用。方法研究对象为年龄在20-71岁、诊断后1-5年、既往存在SMHC的成年癌症幸存者170例和未存在SMHC的80例。他们在面对面的会议中填写了问卷。采用结构方程模型进行多组路径分析。结果SMHC患者在应对癌症方面的自我效能较低，而抑郁症状水平较高。在SMHC组中，认知重评介导了感知沟通质量与自我效能感的关系，表达抑制介导了抑郁症状与自我效能感的关系。结论SMHC患者应对癌症的自我效能感不足，这是影响癌症幸存者治疗依从性和生活质量的重要因素。研究结果表明，自我效能感可以通过与肿瘤团队进行更加强调和细心的沟通以及培养有效的情绪调节策略来增强。

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引用次数: 0

Current state and future directions of biomarkers for bipolar disorder: A systematic review of studies from 2013 to 2025 双相情感障碍生物标志物的现状和未来方向：2013年至2025年研究的系统回顾

IF 2.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-07-23 DOI: 10.1016/j.ejpsy.2025.100317

Guocan Ma , Fengyi Hao , Soon-Kiat Chiang , Dewen Zhou , Roger C. Ho , Roger S. McIntyre

Background and objectives

Bipolar disorder (BD) is a severe mental disorder whose diagnosis heavily relies on subjective symptomatic assessments, thus a need for an objective tool to assist in the timely identification and treatment of BD.

Methods

We systematically reviewed the performance of objective diagnostic biomarkers for classification of BD that presented sensitivity and specificity values. A search on Ovid MEDLINE® ALL, PubMed, as well as manual searching were performed for literature dating from December 2013 to February 2025.

Results

Sixty-one studies were included in the review. Twenty-four of them reported mainly molecular, fluid-based biomarkers, twenty-five reported neurophysiological examinations as biomarkers, and six reported other forms of biomarkers. The most accurate biomarkers included voice features, apoptosis-related long non-coding RNAs, PIK3R1 (Phosphoinositide-3-kinase regulatory subunit 1) and FYN mRNAs, electroencephalography (EEG), functional near-infrared spectroscopy (fNIRS), multimodal magnetic resonance imaging (MRI), and serum VGF protein, with area under the receiver operating characteristic curve (AUC) or accuracy values of greater than 0.93. The majority (thirty-six) of the studies utilized machine learning-based classification algorithms.

Conclusions

The results have been promising and replicated for some biomarkers, but these results still need to be validated in larger samples. Future studies should focus on constructing larger cohorts of specific clinical subtypes of BD, predictive utility studies for BD patients initially diagnosed as major depressive disorder (MDD), and utilization of multimodal assessment and machine learning techniques.

背景与目的双相情感障碍（BD）是一种严重的精神障碍，其诊断严重依赖于主观症状评估，因此需要一种客观的工具来帮助及时识别和治疗。方法我们系统地回顾了客观诊断生物标志物在双相情感障碍分类中的表现，这些生物标志物具有敏感性和特异性。在Ovid MEDLINE®ALL、PubMed上进行检索，并对2013年12月至2025年2月的文献进行人工检索。结果共纳入61项研究。其中24个主要报告了分子的、基于液体的生物标志物，25个报告了神经生理检查作为生物标志物，6个报告了其他形式的生物标志物。最准确的生物标志物包括语音特征、凋亡相关的长链非编码rna、PIK3R1（磷酸肌醇-3激酶调节亚基1）和FYN mrna、脑电图（EEG）、功能近红外光谱（fNIRS）、多模态磁共振成像（MRI）和血清VGF蛋白，受试者工作特征曲线下面积（AUC）或准确度值大于0.93。大多数（36项）研究使用了基于机器学习的分类算法。结论对于一些生物标记物，这些结果是有希望的，并且可以复制，但这些结果仍然需要在更大的样本中进行验证。未来的研究应侧重于构建更大的双相障碍特定临床亚型队列，对最初诊断为重度抑郁症（MDD）的双相障碍患者进行预测效用研究，并利用多模态评估和机器学习技术。

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引用次数: 0

Impact of suicide and COVID-19 in different countries: Epidemiological data for 2020 自杀和COVID-19在不同国家的影响：2020年流行病学数据

IF 2.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-07-19 DOI: 10.1016/j.ejpsy.2025.100316

Jimena María Merayo-Cano , Alejandro Porras-Segovia , Luis Gutiérrez-Rojas , Enrique Baca-García

Background and Objectives

Suicide is a major public health problem. The number of years of potential life lost (YPLL) provides a complementary perspective for mortality assessment and health policy development. Previous studies have compared YPLL due to suicide with YPLL due to COVID-19 in the United States and Spain. However, no previous studies have explored these data worldwide to establish an adequate comparison. We believe that suicide deaths do not receive adequate attention when compared, for example, to deaths attributable to COVID-19. 1 In this case we have performed a comparative analysis of the years of life lost due to suicide and the pandemic, based on data that have been published in recent years. This study aims to quantify the global impact of suicide versus COVID-19 in terms of YPLL.

Methods

Our source was the World Health Organization mortality database as of September 2023. We included countries that had data on all-cause mortality for ages 0-75, presented by age groups in 2020. For suicide and COVID-19, YPLL and the percentage of YPLL over total causes of death were analyzed.

Results

In 10 out of 22 countries (45 %), YPLL due to suicide exceeded those due to COVID-19.

Conclusions

The countries where the impact of suicide was greater than that produced by COVID-19 were Australia and Germany. Although all countries in the world for which data was available were analyzed, Europe was the region with the highest representation. In the case of Europe, the world region with the largest number of countries for which data are available, half of the countries analyzed have a higher number of years of potential life lost as a result of suicide than those lost due to COVID-19, the disease that became one of the leading causes of death in record time, with devastating socio-economic impact and damage. It is necessary to raise awareness about the impact of suicide. Suicide prevention requires a coordinated effort worldwide.

背景与目的自杀是一个重大的公共卫生问题。潜在寿命损失年数（YPLL）为死亡率评估和卫生政策制定提供了补充视角。之前的研究比较了美国和西班牙因自杀导致的YPLL与因COVID-19导致的YPLL。然而，以前没有研究在全球范围内探索这些数据以建立充分的比较。我们认为，与COVID-19造成的死亡相比，自杀死亡没有得到足够的关注。在这种情况下，我们根据近年来发表的数据，对自杀和流行病造成的生命损失年数进行了比较分析。本研究旨在量化自杀与COVID-19在YPLL方面的全球影响。方法本研究来源为截至2023年9月的世界卫生组织死亡率数据库。我们纳入了拥有2020年0-75岁年龄组全因死亡率数据的国家。对于自杀和COVID-19，分析YPLL和YPLL占总死亡原因的百分比。结果在22个国家中，有10个国家（45%）因自杀导致的YPLL超过了因COVID-19导致的YPLL。结论自杀的影响大于新冠肺炎的国家是澳大利亚和德国。虽然对世界上所有可获得数据的国家进行了分析，但欧洲是代表性最高的区域。欧洲是世界上可获得数据的国家最多的区域，在所分析的国家中，有一半国家因自杀而损失的潜在寿命年数高于因COVID-19而损失的寿命年数，这种疾病在创纪录的时间内成为主要死亡原因之一，造成了毁灭性的社会经济影响和损害。有必要提高人们对自杀影响的认识。预防自杀需要全世界的协调努力。

{"title":"Impact of suicide and COVID-19 in different countries: Epidemiological data for 2020","authors":"Jimena María Merayo-Cano , Alejandro Porras-Segovia , Luis Gutiérrez-Rojas , Enrique Baca-García","doi":"10.1016/j.ejpsy.2025.100316","DOIUrl":"10.1016/j.ejpsy.2025.100316","url":null,"abstract":"<div><h3>Background and Objectives</h3><div>Suicide is a major public health problem. The number of years of potential life lost (YPLL) provides a complementary perspective for mortality assessment and health policy development. Previous studies have compared YPLL due to suicide with YPLL due to COVID-19 in the United States and Spain. However, no previous studies have explored these data worldwide to establish an adequate comparison. We believe that suicide deaths do not receive adequate attention when compared, for example, to deaths attributable to COVID-19. 1 In this case we have performed a comparative analysis of the years of life lost due to suicide and the pandemic, based on data that have been published in recent years. This study aims to quantify the global impact of suicide versus COVID-19 in terms of YPLL.</div></div><div><h3>Methods</h3><div>Our source was the World Health Organization mortality database as of September 2023. We included countries that had data on all-cause mortality for ages 0-75, presented by age groups in 2020. For suicide and COVID-19, YPLL and the percentage of YPLL over total causes of death were analyzed.</div></div><div><h3>Results</h3><div>In 10 out of 22 countries (45 %), YPLL due to suicide exceeded those due to COVID-19.</div></div><div><h3>Conclusions</h3><div>The countries where the impact of suicide was greater than that produced by COVID-19 were Australia and Germany. Although all countries in the world for which data was available were analyzed, Europe was the region with the highest representation. In the case of Europe, the world region with the largest number of countries for which data are available, half of the countries analyzed have a higher number of years of potential life lost as a result of suicide than those lost due to COVID-19, the disease that became one of the leading causes of death in record time, with devastating socio-economic impact and damage. It is necessary to raise awareness about the impact of suicide. Suicide prevention requires a coordinated effort worldwide.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 4","pages":"Article 100316"},"PeriodicalIF":2.5,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

National suicide prevention Spanish platform: Creation and components 全国预防自杀西班牙语平台：创建和组成

IF 2.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-05-29 DOI: 10.1016/j.ejpsy.2025.100314

Elizabeth Suárez-Soto , Yolanda Sánchez-Carro , Andrés Pemau , Adriana García-Ramos , Marina Díaz-Marsá , Iria Grande , Pilar Alejandra Sáiz , Miguel Ruiz-Veguilla , Ángela Palao-Tarrero , Annabel Cebrià , Matilde Elices , Ana González-Pinto , José Luis Ayuso , Víctor Pérez Solà , Alejandro de la Torre-Luque

Background and Objectives

Suicide represents a significant global public health challenge, with a concerning increase in Spain, particularly among young adults. In response, the National Platform for the Study and Prevention of Suicide was established. This article provides a descriptive overview of its creation, structural components, and public engagement data.

Methods

The platform integrates multiple components, including geospatial and temporal epidemiological surveillance models, annual reports on suicide trends, and user-friendly data visualization tools that provide regional and national insights. It also addresses public interest by disseminating evidence-based information and preventive resources.

Results

Since its launch in October 2021 through January 13, 2025, the platform recorded 53,159 visits, indicating significant public interest in geographic suicide data and preventive resources. Most visitors are from Spain (86 %), with notable international interest, particularly from the United States and Latin America.

Conclusion

The National Platform has proven to be a valuable tool for suicide prevention in Spain, leveraging digital innovation to enhance public awareness and epidemiological monitoring. Its focus on geospatial data and user interaction underscores its potential to inform public health responses and support evidence-based interventions.

背景和目的自杀是全球公共卫生面临的一项重大挑战，在西班牙自杀率的上升令人担忧，尤其是在年轻人中。为此，建立了国家自杀研究和预防平台。本文提供了其创建、结构组件和公众参与数据的描述性概述。方法该平台集成了多个组件，包括地理空间和时间流行病学监测模型、自杀趋势年度报告以及提供区域和国家见解的用户友好型数据可视化工具。它还通过传播循证信息和预防资源来处理公众利益。自2021年10月推出至2025年1月13日，该平台记录了53159次访问，表明公众对地理自杀数据和预防资源的重大兴趣。大多数游客来自西班牙（86%），国际游客尤其来自美国和拉丁美洲。国家平台已被证明是西班牙预防自杀的宝贵工具，利用数字创新来提高公众意识和流行病学监测。它注重地理空间数据和用户互动，强调了其为公共卫生对策提供信息和支持循证干预措施的潜力。

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引用次数: 0