European Journal of Psychiatry最新文献_第3页

Clinical practice and metabolic consequences of olanzapine use in schizophrenia: results from a national survey in Spain 精神分裂症患者使用奥氮平的临床实践和代谢后果：来自西班牙全国调查的结果

IF 1.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-10-01 DOI: 10.1016/j.ejpsy.2025.100323

L.I. Muñoz-Manchado , M. Bernardo , J.M. Villagrán-Moreno , E. Fernández-Egea

Background and objectives

Schizophrenia is a psychiatric disorder with a global crude prevalence of approximately 23.6 million individuals and ranks among the top ten leading causes of disability worldwide. Antipsychotic medications, including olanzapine (Zyprexa), represent the most effective treatment option for these patients. This study aimed to assess the current prescribing patterns of olanzapine (Zyprexa).

Methods

To explore real-world prescribing patterns of olanzapine (Zyprexa), patient adherence, and the perceived incidence of adverse effects—especially metabolic syndrome—a structured, purpose-designed survey was distributed to psychiatrists across Spain.

Results

A total of 197 Consultant psychiatrists practising in Spain responded to a survey on olanzapine (Zyprexa) use patterns. olanzapine (Zyprexa) was noted for its high efficacy, rapid onset of action, and tolerability. The majority of psychiatrists (77.8 %) reported prescribing olanzapine (Zyprexa) primarily to patients aged 31–50 years. Regarding metabolic syndrome, out of 111 responses, 60.4 % (66 psychiatrists) considered olanzapine (Zyprexa) to be associated with a higher incidence of metabolic syndrome, which was reported to occur predominantly at an early stage (61.3 %).

Conclusions

Treatment adherence to olanzapine (Zyprexa) may be negatively affected by adverse events such as weight gain and the development of metabolic syndrome, which could serve as causal factors for treatment discontinuation. The implementation of both pharmacological and non-pharmacological strategies aimed at metabolic control may play a key role in optimizing the therapeutic management of schizophrenia.

背景与目的精神分裂症是一种精神疾病，全球粗略患病率约为2360万人，是全球十大致残原因之一。抗精神病药物，包括奥氮平（再普乐），是这些患者最有效的治疗选择。本研究旨在评估目前奥氮平（再普乐）的处方模式。方法为了探索现实世界中奥氮平（再普乐）的处方模式、患者依从性和不良反应（尤其是代谢综合征）的感知发生率，对西班牙的精神科医生进行了一项结构化的、有目的的调查。结果西班牙197名执业精神科咨询医师对奥氮平（再普乐）使用情况进行了调查。奥氮平（再普乐）以其高效、起效快和耐受性而闻名。大多数精神科医生（77.8%）报告主要给31-50岁的患者开奥氮平（再普乐）。关于代谢综合征，在111名应答者中，60.4%（66名精神科医生）认为奥氮平（再普乐）与代谢综合征的较高发生率相关，据报道代谢综合征主要发生在早期（61.3%）。结论奥氮平（再普乐）治疗依从性可能受到体重增加和代谢综合征发生等不良事件的负面影响，这些不良事件可能是导致停药的原因。针对代谢控制的药物和非药物策略的实施可能在优化精神分裂症的治疗管理中发挥关键作用。

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引用次数: 0

Self-reported and performance-based emotional intelligence and its associations with psychopathological dimensions and insight dimensions in psychosis 自我报告和基于表现的情绪智力及其与精神病的精神病理维度和洞察力维度的关系

IF 1.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-10-01 DOI: 10.1016/j.ejpsy.2025.100328

Esther Rosado , Amalia Zarzuela , Gustavo J. Gil-Berrozpe , Xabier Ansorena , Julen Chato , Victor Peralta , Manuel J. Cuesta , Ana M. Sánchez-Torres

Background and objectives

Individuals with psychotic disorders may display over the illness course a wide range of core deficits in clinical and cognitive domains, including social cognition (SC). One of the main domains of SC is emotional processing, a key component of emotional intelligence (EI). However, the extent to which EI, as self-perceived or performance-based, is related to psychopathological domains has been scarcely studied. This study aimed to examine the relationships between self-reported EI and performance-based EI with psychopathological and insight dimensions as well as to explore the correspondence between both types of EI assessments.

Methods

Seventy patients with psychotic disorders who were consecutively admitted to a psychiatric hospitalization unit were included. Psychotic, affective, and insight dimensions, as well as EI, were evaluated once psychopathological stability had been achieved.

Results

Manic symptoms were associated with greater emotional clarity (r = 0.25, p < 0.05) and regulation (r = 0.30, p < 0.05), whereas depressive symptoms were associated with lower emotional regulation (r=-0.25, p < 0.05). No significant relationships were found between the EI measures and psychotic dimensions. Lack of feeling sick and lack of insight were related to worse performance-based EI (emotional management, r=-0.29 and r=-0.25, p < 0.05) and self-reported EI (emotional attention, r=-0.24, p < 0.05 and r=-0.31, p < 0.01), and the former was also related to better emotional regulation (r = 0.26, p < 0.05).

Conclusion

The discrepancy between self-reported and performance-based EI regarding their associations with psychopathological domains might be due to the different sources of assessment but may also add evidence to the need to integrate patient-reported outcome measures in the assessment of social cognition.

背景和目的精神病患者在病程中可能表现出临床和认知领域的广泛核心缺陷，包括社会认知（SC）。情感处理是情感智力（EI）的一个重要组成部分。然而，在多大程度上，EI，作为自我感知或绩效为基础，是与精神病理领域的研究很少。本研究旨在探讨自我报告型情商和绩效型情商在精神病理和洞察力维度上的关系，并探讨两种情商评估之间的对应关系。方法选取连续入住精神科的70例精神障碍患者。一旦达到精神病理稳定，就对精神病、情感和洞察力维度以及EI进行评估。结果躁狂症状与情绪清晰度（r= 0.25, p < 0.05）和情绪调节能力（r= 0.30, p < 0.05）相关，抑郁症状与情绪调节能力较低相关（r=-0.25, p < 0.05）。在EI测量和精神病维度之间没有发现显著的关系。缺乏感觉不适和缺乏洞察力与较差的绩效EI（情绪管理，r=-0.29和r=-0.25, p < 0.05）和自我报告的EI（情绪注意，r=-0.24, p <； 0.05和r=-0.31, p < 0.01）有关，而缺乏洞察力和较好的情绪调节也与较好的情绪调节有关（r = 0.26, p < 0.05）。结论自我报告和基于绩效的EI与精神病理领域的关联存在差异，这可能是由于评估来源不同，但也可能表明需要将患者报告的结果测量纳入社会认知评估中。

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引用次数: 0

Measuring referentiality in psychiatric disorders: Psychometric properties of the Spanish version of the Ideas of Reference and Interview Scale (IRIS-S) 精神疾病的参照性测量：西班牙语版参考与访谈量表（IRIS-S）的心理测量特性

IF 1.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-10-01 DOI: 10.1016/j.ejpsy.2025.100329

Isabel Argila-Plaza , Ana Aquino-Servín , María Ángeles García-León , Paola Fuentes-Claramonte , Núria Ramiro , Pilar Salgado-Pineda , Joan Soler-Vidal , María Llanos Torres , Amalia Guerrero-Pedraza , Manel Sánchez , Salvador Sarró , Raymond Salvador , Peter J McKenna , Ana Barajas , Edith Pomarol-Clotet

Background and objectives

Referentiality is a common symptom in psychotic and also some non-psychotic disorders, but there are few existing measures for assessing it. A recently developed detailed measure for this purpose is the Ideas of Reference Interview Scale (IRIS), which however has only been validated in a Chinese population of first episode psychosis patients.

Methods

We examined the reliability and validity of a Spanish version of the IRIS (IRIS-S) in 185 patients aged between 18 and 65 with schizophrenia or schizoaffective disorder.

Results

The IRIS-S showed internal consistency, with this being good or acceptable for the presence scale and its three subsidiary measures. Inter-rater reliability was good and test-retest reliability was also good, except for one subsidiary measure. Convergent reliability was demonstrated but was lower than expected.

Conclusion

The IRIS-S has acceptable psychometric properties when employed in patients with schizophrenia/schizoaffective disorder. Caution is necessary for its use outside psychotic disorders as it has not been examined in such populations.

背景与目的参考性是精神障碍和一些非精神障碍的常见症状，但现有的评估方法很少。参考访谈量表（Ideas of Reference Interview Scale， IRIS）是最近开发的一种详细的测量方法，但它只在中国首发精神病患者中得到验证。方法我们对185例年龄在18 - 65岁的精神分裂症或分裂情感性障碍患者进行了西班牙语版IRIS （IRIS- s）的信度和效度检验。结果IRIS-S量表具有内部一致性，存在度量表及其三个辅助指标的一致性良好或可接受。量表间信度较好，重测信度也较好。证明了收敛可靠性，但低于预期。结论IRIS-S在精神分裂症/分裂情感性障碍患者中具有良好的心理测量特性。在精神疾病之外使用它是必要的，因为它还没有在这类人群中被检验过。

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引用次数: 0

Features of Spanish non-commercial non-pharmacological completed clinical trials in psychiatry 西班牙非商业非药理完成精神病学临床试验的特点

IF 1.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-10-01 DOI: 10.1016/j.ejpsy.2025.100330

Rafael Dal-Ré , Elena García-Méndez , Ignacio Mahillo-Fernández

引用次数: 0

Psychometric validation of the self-administered French version of the Functioning Assessment Short Test (FAST): Factor structure, reliability, validity, and sociodemographic predictors 自我管理法语版功能评估短测验（FAST）的心理计量学验证：因素结构、信度、效度和社会人口预测因子

IF 1.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-09-26 DOI: 10.1016/j.ejpsy.2025.100325

Audrey Uyttersprot , Nellia Bellaert , Eduard Vieta , Sandra Invernizzi , Laurence Ris , Laurent Lefebvre

Background and objectives

The Functioning Assessment Short Test (FAST) is widely used to assess psychosocial functioning across psychiatric conditions. Despite extensive international validation, a validated French version of the self-administered FAST is currently lacking. This study aimed to evaluate the psychometric properties of the self-administered French FAST in a general adult population.

Methods

A total of 508 French-speaking adults aged 18–65 completed the FAST alongside standardized measures of depression and anxiety. Exploratory and confirmatory factor analyses and bifactor modeling evaluated the original six-factor structure. Reliability was assessed using Cronbach’s alpha and McDonald’s omega. Convergent validity was evaluated through multitrait-multimethod (MTMM) analysis and correlations with depression and anxiety. Generalized additive models (GAMs) examined non-linear associations between symptom severity and FAST scores, controlling for demographic covariates.

Results

The original six-factor structure was confirmed, and the bifactor model further supported interpretation of both total and subscale scores. Reliability was strong for the total FAST score (α = .86; ω = .90), whereas subscale reliability (α = .58–.80), with lower values for autonomy, cognitive, and leisure. MTMM analysis demonstrated moderate-to-high monotrait correlations (.51–.84), and moderate correlations with depressive (r = .46) and anxiety (r = .35) symptoms, supporting convergent validity. GAM analyses revealed a non-linear relationship between depressive symptoms and psychosocial impairment (edf = 2.91, F = 19.87, p < .001), alongside significant effects of anxiety (p = .024) and employment status (p = .003).

Conclusions

The French self-administered FAST demonstrates robust psychometric properties and appears suitable for assessing psychosocial functioning in general adult populations, though caution is advised when interpreting autonomy, cognitive, and leisure subscales in non-clinical samples until further clinical validation is available.

背景和目的功能评估短测试（FAST）被广泛用于评估精神疾病的社会心理功能。尽管得到了广泛的国际认可，但目前还缺乏经过验证的法语版自我管理FAST。本研究旨在评估一般成年人自我管理的法语FAST的心理测量特性。方法共有508名年龄在18-65岁的法语成年人完成了FAST，并进行了标准化的抑郁和焦虑测量。探索性和验证性因子分析和双因子模型评估了原来的六因子结构。采用Cronbach 's alpha和McDonald 's omega评估信度。通过多特质-多方法（MTMM）分析评估收敛效度，并与抑郁和焦虑进行相关性分析。广义加性模型（GAMs）检验了症状严重程度和FAST评分之间的非线性关联，控制了人口统计学协变量。结果原来的六因子结构得到证实，双因子模型进一步支持总分和分量表得分的解释。FAST总分的信度较高（α = 0.86; ω = 0.90），而次量表的信度较高（α = 0.58 - 0.90）。80)，自主性、认知和休闲的价值较低。MTMM分析显示了中至高的单性状相关性（0.51 -）。84)，并且与抑郁（r = 0.46）和焦虑（r = 0.35）症状有中度相关性，支持收敛效度。GAM分析显示，抑郁症状与心理社会障碍之间存在非线性关系（edf = 2.91, F = 19.87, p < .001），焦虑（p = 0.024）和就业状况（p = 0.003）也有显著影响。结论：法国自我管理的FAST显示出强大的心理测量特性，似乎适用于评估一般成年人的社会心理功能，尽管在解释非临床样本的自主性、认知和休闲亚量表时建议谨慎，直到进一步的临床验证可用。

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引用次数: 0

Spanish validation of “The Awareness of Social Inference Test” (TASIT) “社会推理意识测试”（TASIT）的西班牙语验证

IF 1.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-09-16 DOI: 10.1016/j.ejpsy.2025.100324

Lorena García-Fernández , Nuria Cabot Iborra , Verónica Romero-Ferreiro , Miguel A. Álvarez-Mon , Estela Jiménez López , Guillermo Lahera , Skye McDonald , Roberto Rodriguez-Jimenez

Background and objectives

Social cognition (SC) plays a fundamental role in interpersonal functioning and is often impaired in severe mental disorders like schizophrenia. The Awareness of Social Inference Test (TASIT) is a reliable tool for assessing SC through audiovisual vignettes, but a validated Spanish version was lacking. This study aimed to translate, adapt, and validate TASIT for Spanish-speaking populations.

Method

A cross-sectional study was conducted with 659 participants, including healthy individuals and people with schizophrenia. The TASIT was translated and adapted following a rigorous procedure with the participation and guidance of the original author. Reliability, convergent, and discriminant validity were assessed using established psychometric tools.

Results

The Spanish version of TASIT demonstrated strong internal consistency across all sections, with McDonald’s omega coefficients ranging from ω = 0.71 to 0.89. Test-retest reliability was excellent, with correlation coefficients ranging from r = 0.81 to 0.87 (all p < .001). Convergent validity was supported by significant correlations with established social cognition measures (p < .05), and discriminant validity was confirmed by significant performance differences between healthy participants and those with schizophrenia (p < .05).

Conclusions

The Spanish TASIT is a valid and reliable tool for assessing SC, with strong psychometric properties. It is suitable for both clinical and research settings.

背景与目的社会认知（SC）在人际关系中起着重要作用，在精神分裂症等严重精神障碍中经常受损。社会推理意识测试（TASIT）是一种可靠的工具，通过视听小插曲评估SC，但缺乏有效的西班牙语版本。本研究旨在为西班牙语人群翻译、调整和验证TASIT。方法对659名健康个体和精神分裂症患者进行横断面研究。在原作者的参与和指导下，按照严格的程序进行了翻译和改编。采用已建立的心理测量工具评估信度、收敛效度和判别效度。结果西班牙语版本的TASIT在所有部分表现出很强的内部一致性，麦当劳的ω系数范围为ω = 0.71至0.89。重测信度极好，相关系数r = 0.81 ~ 0.87（均p <； .001）。与已建立的社会认知测量的显著相关性支持了收敛效度（p < 0.05），健康参与者和精神分裂症患者之间的显著表现差异证实了区别效度（p < 0.05）。结论西班牙语TASIT量表具有较强的心理测量特性，是一种有效、可靠的SC评估工具。它适用于临床和研究设置。

{"title":"Spanish validation of “The Awareness of Social Inference Test” (TASIT)","authors":"Lorena García-Fernández , Nuria Cabot Iborra , Verónica Romero-Ferreiro , Miguel A. Álvarez-Mon , Estela Jiménez López , Guillermo Lahera , Skye McDonald , Roberto Rodriguez-Jimenez","doi":"10.1016/j.ejpsy.2025.100324","DOIUrl":"10.1016/j.ejpsy.2025.100324","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Social cognition (SC) plays a fundamental role in interpersonal functioning and is often impaired in severe mental disorders like schizophrenia. The Awareness of Social Inference Test (TASIT) is a reliable tool for assessing SC through audiovisual vignettes, but a validated Spanish version was lacking. This study aimed to translate, adapt, and validate TASIT for Spanish-speaking populations.</div></div><div><h3>Method</h3><div>A cross-sectional study was conducted with 659 participants, including healthy individuals and people with schizophrenia. The TASIT was translated and adapted following a rigorous procedure with the participation and guidance of the original author. Reliability, convergent, and discriminant validity were assessed using established psychometric tools.</div></div><div><h3>Results</h3><div>The Spanish version of TASIT demonstrated strong internal consistency across all sections, with McDonald’s omega coefficients ranging from ω = 0.71 to 0.89. Test-retest reliability was excellent, with correlation coefficients ranging from <em>r</em> = 0.81 to 0.87 (all <em>p</em> < .001). Convergent validity was supported by significant correlations with established social cognition measures (<em>p</em> < .05), and discriminant validity was confirmed by significant performance differences between healthy participants and those with schizophrenia (<em>p</em> < .05).</div></div><div><h3>Conclusions</h3><div>The Spanish TASIT is a valid and reliable tool for assessing SC, with strong psychometric properties. It is suitable for both clinical and research settings.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 4","pages":"Article 100324"},"PeriodicalIF":1.5,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Telehealth group parent training for children with autism spectrum disorder and behavioral difficulties: feasibility, acceptability and preliminary efficacy 远程医疗团体家长训练对自闭症谱系障碍和行为困难儿童的可行性、可接受性和初步效果

IF 1.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-08-22 DOI: 10.1016/j.ejpsy.2025.100319

Imanol Setien-Ramos , Teresa Alonzo-Castillo , Aina García-Martínez , Jorge Lugo-Marín , María Martínez-Ramírez , Josep Antoni Ramos-Quiroga , Laura Gisbert-Gustemps

Background and objectives

Children with Autism Spectrum Disorder (ASD) frequently experience significant behavioral challenges that hinder adaptive functioning and increase caregiver stress. This study assesses the feasibility, acceptability, and preliminary efficacy of a telehealth-delivered group parent training program designed to address behavioral difficulties in children with ASD.

Method

An open-label, single-arm trial was conducted with children aged 3–12 years diagnosed with ASD and behavioral difficulties, recruited from a tertiary hospital’s autism care program. Program effectiveness was evaluated using parent-reported measures on their children and on themselves assessing behavior problems, parental stress, and quality of life. Data analysis included pre-post comparisons and follow-up assessments at 3 and 6 months.

Results

Twenty dyads parent-children were analyzed. Satisfaction with the program was moderate, with especially favorable feedback on the "planned ignoring" unit. Preferences for delivery mode and format varied, with suggestions to reduce the number of tasks and tailor content to individual needs. Significant reductions in irritability, lethargy, hyperactivity were observed immediately after treatment, with improvements in irritability and hyperactivity sustained at the 3- and 6-month follow-ups. Parental stress decreased significantly post-treatment but did not persist over time. Quality of life improved significantly compared to baseline, both immediately post-treatment and during follow-up evaluations.

Conclusions

The telehealth-delivered group parent training program demonstrated feasibility and moderate acceptability, with significant improvements in child behavior and caregiver quality of life. However, the reduction in parental stress was not sustained over time. These findings underscore the potential of telehealth-delivered group interventions for managing ASD-related behavioral issues and indicate areas for program refinement to enhance adherence and long-term effectiveness.

背景和目的自闭症谱系障碍（ASD）儿童经常经历严重的行为挑战，这些挑战阻碍了适应功能并增加了照顾者的压力。本研究评估了远程医疗提供的小组家长培训计划的可行性、可接受性和初步效果，该计划旨在解决自闭症儿童的行为困难。方法进行一项开放标签单臂试验，从一家三级医院的自闭症护理项目中招募3-12岁被诊断为ASD和行为困难的儿童。通过父母对孩子和他们自己的行为问题、父母压力和生活质量的评估来评估项目的有效性。数据分析包括前后比较和3个月和6个月的随访评估。结果对20对父子进行了分析。对该计划的满意度是中等的，对“计划忽视”单元的反馈尤其有利。对于交付模式和格式的偏好各不相同，建议减少任务数量并根据个人需求定制内容。治疗后立即观察到易怒、嗜睡、多动明显减少，在3个月和6个月的随访中，易怒和多动持续改善。父母的压力在治疗后显著减少，但没有持续一段时间。治疗后和随访期间的生活质量与基线相比均有显著改善。结论远程医疗团体家长培训项目具有可行性和可接受性，在儿童行为和照顾者生活质量方面有显著改善。然而，父母压力的减少并没有随着时间的推移而持续。这些发现强调了远程医疗提供的群体干预在管理自闭症相关行为问题方面的潜力，并指出了改进项目的领域，以提高依从性和长期有效性。

{"title":"Telehealth group parent training for children with autism spectrum disorder and behavioral difficulties: feasibility, acceptability and preliminary efficacy","authors":"Imanol Setien-Ramos , Teresa Alonzo-Castillo , Aina García-Martínez , Jorge Lugo-Marín , María Martínez-Ramírez , Josep Antoni Ramos-Quiroga , Laura Gisbert-Gustemps","doi":"10.1016/j.ejpsy.2025.100319","DOIUrl":"10.1016/j.ejpsy.2025.100319","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Children with Autism Spectrum Disorder (ASD) frequently experience significant behavioral challenges that hinder adaptive functioning and increase caregiver stress. This study assesses the feasibility, acceptability, and preliminary efficacy of a telehealth-delivered group parent training program designed to address behavioral difficulties in children with ASD.</div></div><div><h3>Method</h3><div>An open-label, single-arm trial was conducted with children aged 3–12 years diagnosed with ASD and behavioral difficulties, recruited from a tertiary hospital’s autism care program. Program effectiveness was evaluated using parent-reported measures on their children and on themselves assessing behavior problems, parental stress, and quality of life. Data analysis included pre-post comparisons and follow-up assessments at 3 and 6 months.</div></div><div><h3>Results</h3><div>Twenty dyads parent-children were analyzed. Satisfaction with the program was moderate, with especially favorable feedback on the \"planned ignoring\" unit. Preferences for delivery mode and format varied, with suggestions to reduce the number of tasks and tailor content to individual needs. Significant reductions in irritability, lethargy, hyperactivity were observed immediately after treatment, with improvements in irritability and hyperactivity sustained at the 3- and 6-month follow-ups. Parental stress decreased significantly post-treatment but did not persist over time. Quality of life improved significantly compared to baseline, both immediately post-treatment and during follow-up evaluations.</div></div><div><h3>Conclusions</h3><div>The telehealth-delivered group parent training program demonstrated feasibility and moderate acceptability, with significant improvements in child behavior and caregiver quality of life. However, the reduction in parental stress was not sustained over time. These findings underscore the potential of telehealth-delivered group interventions for managing ASD-related behavioral issues and indicate areas for program refinement to enhance adherence and long-term effectiveness.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 4","pages":"Article 100319"},"PeriodicalIF":1.5,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144886724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association of α-klotho/fibroblast growth factor 23 with cognitive features in euthymic older age patients with bipolar disorder α-klotho/成纤维细胞生长因子23与老年健康双相障碍患者认知特征的关系

IF 1.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-08-21 DOI: 10.1016/j.ejpsy.2025.100320

Wen-Yin Chen , Chih Chiang Chiu , Po-Hsiu Kuo , Cho-Yin Huang , Shang-Ying Tsia , Chian-Jue Kuo , Ying-Chih Cheng , Po-Yu Chen , Ming-Chyi Huang

Background and objectives

Cognitive aging is common among bipolar disorder (BD). The α-klotho/fibroblast growth factor 23 (FGF23) system has been associated with neuropsychiatric disorders and age-related diseases. This study aimed to investigate α-klotho and FGF23 levels in older-age bipolar disorder (OABD) and examine their associations with aging-related characteristics and cognitive function.

Methods

This study included 87 euthymic OABD, 83 younger-age bipolar disorder (YABD), and 20 healthy controls, to assess α-klotho and FGF23 levels. In OABD group, cognitive function was evaluated using the Brief Assessment of Cognition in Affective Disorders. Aging-related features were assessed, including daily physical activity, grip strength, and the Framingham Risk Score. We examined the correlations between α-klotho/FGF23 levels and aging-related features and explored their associations with cognitive domains in OABD.

Results

The FGF23 levels in OABD were lower compared to those in YABD. The α-klotho levels were not significantly different between three groups. A negative association was observed between FGF23 and global cognitive composite scores (B = -0.006, p = 0.005), particularly in motor speed (B = -0.006, p = 0.001), working memory (B = -0.007, p = 0.006), and verbal fluency (B = -0.002, p = 0.049). Additionally, α-klotho levels were positively associated with working memory (B = 0.735, p = 0.039).

Conclusions

FGF23 had a negative impact on cognitive domains, while α-klotho was positively associated with working memory in OABD. Future research should investigate the dysfunction of the α-klotho/FGF23 axis and incorporate additional validated aging markers in longitudinal studies to confirm the proposed biomarker relationships.

背景与目的认知衰老在双相情感障碍（BD）中很常见。α-klotho/成纤维细胞生长因子23 （FGF23）系统与神经精神疾病和年龄相关疾病有关。本研究旨在探讨老年双相情感障碍（OABD）患者α-klotho和FGF23水平，并探讨其与衰老相关特征和认知功能的关系。方法本研究纳入87例正常心境型OABD、83例年轻型双相情感障碍（YABD）和20例健康对照，评估α-klotho和FGF23水平。在OABD组，认知功能评估使用情感障碍认知简要评估。评估了与衰老相关的特征，包括日常体力活动、握力和Framingham风险评分。我们检测了α-klotho/FGF23水平与衰老相关特征的相关性，并探讨了它们与OABD认知领域的关系。结果OABD组FGF23水平低于YABD组。各组间α-klotho水平差异无统计学意义。FGF23与整体认知综合得分呈负相关（B = -0.006, p = 0.005），特别是在运动速度（B = -0.006, p = 0.001）、工作记忆（B = -0.007, p = 0.006）和语言流畅性（B = -0.002, p = 0.049）方面。α-klotho水平与工作记忆呈正相关（B = 0.735, p = 0.039）。结论sfgf23对OABD患者的认知功能域有负向影响，而α-klotho对OABD患者的工作记忆功能域有正向影响。未来的研究应该研究α-klotho/FGF23轴的功能障碍，并在纵向研究中纳入其他经过验证的衰老标志物，以证实所提出的生物标志物关系。

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引用次数: 0

Functional brain imaging of negative symptoms in schizophrenia: further evidence of prefrontal dysfunction 精神分裂症阴性症状的功能性脑成像：前额叶功能障碍的进一步证据

IF 1.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-08-21 DOI: 10.1016/j.ejpsy.2025.100322

Paola Fuentes-Claramonte , Ana Aquino-Servín , María Ángeles Garcia-León , Jordi Ortiz-Gil , Pilar Salgado-Pineda , Amalia Guerrero-Pedraza , Salvador Sarró , Emilio J. Inarejos-Clemente , Raymond Salvador , Peter J. McKenna , Edith Pomarol-Clotet

Background and objectives

An influential theory of negative symptoms in schizophrenia is that they are due to frontal lobe dysfunction, although this has not been consistently supported by functional imaging studies to date. Recently, our group found evidence of an association between negative symptoms and prefrontal hypoactivation during a novel executive task sensitive to goal neglect. The present study sought to extend this finding using a different functional imaging paradigm, the n-back working memory task.

Methods

Ninety-six medicated patients with schizophrenia were divided according to the Positive and Negative Symptoms Scale (PANSS) scores into groups with high negative symptom scores (HNS, N=70, negative symptom score range 15-34), and with low negative symptom scores (LNS, N=26, negative symptom score range 6-14). Along with 50 matched healthy controls, they underwent fMRI while performing the 2-back and 1-back versions of the n-back task.

Results

In the 2-back vs 1-back comparison, working memory-related activation was observed in lateral prefrontal and inferior parietal areas in all groups. The HNS patients, but not the LNS patients showed reduced activation in these task-related regions compared to the healthy controls. The HNS patients also showed hypoactivation in the right dorsolateral prefrontal cortex relative to the LNS patients, although this finding was no longer statistically significant when disorganization scores were added as a covariate.

Conclusion

Our results provide further evidence supporting the prefrontal hypothesis of negative symptoms, but also highlight the potential role of disorganization in modulating prefrontal activity.

背景和目的精神分裂症阴性症状的一个有影响力的理论是由于额叶功能障碍，尽管迄今为止尚未得到功能影像学研究的一致支持。最近，我们的小组发现了在一个对目标忽视敏感的新执行任务中，消极症状和前额叶失活之间存在关联的证据。本研究试图使用不同的功能成像范式，即n-back工作记忆任务来扩展这一发现。方法将96例精神分裂症服药患者按阳性症状和阴性症状量表（PANSS）评分分为高阴性症状组（HNS， N=70，阴性症状评分范围15 ~ 34）和低阴性症状组（LNS， N=26，阴性症状评分范围6 ~ 14）。与50名匹配的健康对照者一起，他们在执行n-back任务的2-back和1-back版本时接受了功能磁共振成像。结果2-back与1-back比较，两组的前额外侧区和下顶叶区均有工作记忆相关的激活。与健康对照相比，HNS患者在这些任务相关区域的激活减少，而LNS患者则没有。与LNS患者相比，HNS患者的右侧背外侧前额叶皮层也表现出低激活，尽管当将无序性评分作为协变量添加时，这一发现不再具有统计学意义。结论本研究结果进一步支持了消极症状的前额叶假说，同时也强调了紊乱在调节前额叶活动中的潜在作用。

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引用次数: 0

Self-efficacy for coping with cancer among cancer survivors with preexisting mental health conditions versus a control group 先前存在心理健康问题的癌症幸存者与对照组之间应对癌症的自我效能感

IF 2.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-07-25 DOI: 10.1016/j.ejpsy.2025.100318

Miri Cohen , Marc Gelkopf

Background and objectives

Self-efficacy for coping with cancer is a significant factor for cancer survivors’ quality of life, but it has not been examined among individuals with preexisting severe mental health conditions (SMHC). This study compared perceptions of self-efficacy for coping with cancer among cancer survivors with and without precancer SMHC; quality of communication with the oncology team and depressive symptoms as antecedents of self-efficacy; and the mediating role of self-regulation (cognitive reappraisal and expressive suppression) between antecedents and perceived self-efficacy for coping with cancer.

Methods

Participants were 170 adult cancer survivors with preexisting SMHC and 80 with no SMHC, aged 20–71, and 1–5 years since diagnosis. They filled out questionnaires in a face-to-face meeting. Multigroup path analysis was conducted using structural equation modeling.

Results

Individuals with SMHC reported lower self-efficacy for coping with cancer and higher levels of depressive symptoms. In the SMHC group, cognitive reappraisal mediated the association between perceived communication quality and self-efficacy, and expressive suppression mediated the relationship between depressive symptoms and self-efficacy.

Conclusions

The results highlight the deficiency in self-efficacy for coping with cancer in individuals with SMHC, a prominent factor for treatment adherence and quality of life among cancer survivors. Findings suggest self-efficacy may be strengthened via more emphatic and attentive communication with the oncology team and fostering effective emotion regulation strategies.

背景与目的应对癌症的自我效能感是影响癌症幸存者生活质量的一个重要因素，但尚未在患有严重精神健康状况（SMHC）的个体中进行研究。本研究比较了有和没有癌前SMHC的癌症幸存者应对癌症的自我效能感；与肿瘤团队的沟通质量和抑郁症状作为自我效能感的先决条件；自我调节（认知重评和表达抑制）在应对癌症的前因由和感知自我效能之间的中介作用。方法研究对象为年龄在20-71岁、诊断后1-5年、既往存在SMHC的成年癌症幸存者170例和未存在SMHC的80例。他们在面对面的会议中填写了问卷。采用结构方程模型进行多组路径分析。结果SMHC患者在应对癌症方面的自我效能较低，而抑郁症状水平较高。在SMHC组中，认知重评介导了感知沟通质量与自我效能感的关系，表达抑制介导了抑郁症状与自我效能感的关系。结论SMHC患者应对癌症的自我效能感不足，这是影响癌症幸存者治疗依从性和生活质量的重要因素。研究结果表明，自我效能感可以通过与肿瘤团队进行更加强调和细心的沟通以及培养有效的情绪调节策略来增强。

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