European Journal of Psychiatry最新文献_第6页

Mental illness discussion variations on X: Topic modelling and sentiment analysis X上的精神疾病讨论变异：话题建模和情感分析

IF 2.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-04-01 Epub Date: 2025-03-21 DOI: 10.1016/j.ejpsy.2025.100300

Javier Domingo-Espiñeira , Andrea Varaona-Santos , Francisco J. Lara Abelenda , María Montero , Emilio Fernandez-Egea , Leticia I Muñoz-Manchado , Miguel A. Ortega , Melchor Álvarez-Mon , Miguel Ángel Álvarez-Mon

Background and objectives

Social Media Listening has become essential for understanding societal attitudes about mental health. However, there is a lack of studies focusing on Spanish-language discussions and long-term analyses. This study aims to investigate the evolution of Spanish and English public discourse on nine psychiatric disorders over 15 years on X, identifying frequently addressed topics and associated emotions.

Methods

We collected and analyzed tweets in English and Spanish from 2007 to 2022, referring to nine psychiatric disorders (autism, ADHD, schizophrenia, bipolar disorder, depressive episode, anxiety, addictions, insomnia, and suicide). Advanced topic modeling and sentiment analysis were applied.

Results

The study revealed differences in tweet volumes across disorders and languages. Anxiety was the most prevalent term in both Spanish and English tweets. Spanish discussions emphasized insomnia and suicide attempts, while English tweets highlighted autism and schizophrenia. Tweets about bipolar disorder, depressive episode, and addictions were consistently low in both languages. Over time, Spanish tweets on insomnia, anxiety, and suicide attempts increased, while English tweets on autism, anxiety, suicide attempts, and schizophrenia spiked in 2018 and 2019. Topic modeling indicated that Spanish tweets focused on personal experiences with mental disorders and their impact on life, primarily associated with anger, fear, sadness, and joy. English tweets centered on social awareness and advocacy, eliciting fear, followed by treatment and prevention, associated with fear and sadness.

Conclusions

Despite fewer discussions on X about severe mental disorders like bipolar disorder, schizophrenia, and addictions, X serves as a supportive environment for mental health discourse. Spanish-speaking users share personal experiences, fostering self-expression, while English users promote social awareness and advocacy. This highlights X's role in normalizing mental health conversations, reducing stigma, and increasing support.

背景和目的社交媒体倾听对于理解社会对心理健康的态度已经变得至关重要。然而，缺乏关注西班牙语讨论和长期分析的研究。本研究旨在调查15年来西班牙语和英语关于9种精神疾病的公共话语的演变，确定经常被提及的话题和相关情绪。方法收集并分析2007年至2022年9种精神疾病（自闭症、多动症、精神分裂症、双相情感障碍、抑郁发作、焦虑、成瘾、失眠和自杀）的英语和西班牙语推文。应用了先进的主题建模和情感分析。研究揭示了不同疾病和语言的推特数量的差异。焦虑是西班牙语和英语推特中最普遍的词汇。西班牙语的讨论强调失眠和自杀企图，而英语的推文则强调自闭症和精神分裂症。两种语言中关于双相情感障碍、抑郁发作和成瘾的推文一直很低。随着时间的推移，关于失眠、焦虑和自杀企图的西班牙语推文增加了，而关于自闭症、焦虑、自杀企图和精神分裂症的英语推文在2018年和2019年激增。话题建模表明，西班牙语推文关注的是精神障碍的个人经历及其对生活的影响，主要与愤怒、恐惧、悲伤和快乐有关。英语推文以社会意识和倡导为中心，引发恐惧，其次是治疗和预防，与恐惧和悲伤有关。尽管关于严重精神障碍如双相情感障碍、精神分裂症和成瘾的X讨论较少，但X为精神健康话语提供了一个支持性环境。讲西班牙语的用户分享个人经历，培养自我表达，而英语用户则促进社会意识和倡导。这突出了X在使心理健康对话正常化、减少耻辱感和增加支持方面的作用。

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引用次数: 0

Investigating an intervention program to reduce suicidal behavior in adolescents with psychiatric disorders: A protocol design 调查减少青少年精神疾病患者自杀行为的干预方案：方案设计

IF 2.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-04-01 Epub Date: 2025-03-01 DOI: 10.1016/j.ejpsy.2025.100298

Veronica Fernandez-Rodrigues , Wala Ayad-Ahmed , Paola Marin-Santos , Jose Manuel Lopez-Villatoro , Alejandro de la Torre-Luque , Teresa Bobes-Bascaran , Jose Luis Carrasco , Luis Olivares , Marina Diaz-Marsa

Introduction

Suicide is the leading cause of unnatural death in adolescents. In addition, between 7 and 17% of adolescents may engage in at least one suicide attempt, with prevalence being dramatically higher in adolescents with psychiatric pathology. Death by suicide is usually preceded by several attempts to take one's own life. Among the risk factors most consistently associated with suicidal intent is suicidal ideation. This study aims to evaluate the efficacy of the Self-Awareness of Mental Health (SAM) program enriching standard care, for adolescents at high suicide risk (mental disorder and high suicidal ideation).

Methodology

A randomized single-blind controlled clinical trial will be conducted with a sample of 116 adolescents with suicidal ideation and/or suicide attempt, referred by their psychiatrists from the Hospital Clínico San Carlos (Madrid, Spain). The cohort will be divided into two groups (an intervention group, in which the SAM intervention will be administered as an adjuvant to standard treatment; and a treatment-as-usual group). An extensive clinical assessment on risk factors for suicidal behavior and psychiatric symptoms will be applied up to four times: baseline, post (5 weeks), 3 and 6 months.

Results

Data collection is ongoing. This study will provide data on the effectiveness of the SAM intervention in reducing ideation, preventing the occurrence of suicide attempts, and mitigating emotional symptomatology, such as for anxiety and depression.

自杀是青少年非正常死亡的主要原因。此外，7%至17%的青少年可能至少有过一次自杀企图，而患有精神疾病的青少年的自杀率要高得多。自杀死亡之前通常会有几次自杀的企图。与自杀意图最一致的危险因素是自杀意念。本研究旨在评估心理健康自我意识（SAM）项目对高自杀风险青少年（精神障碍和高自杀意念）标准护理的效果。方法将对116名有自杀意念和/或自杀企图的青少年进行随机单盲对照临床试验，这些青少年由他们的精神科医生从Clínico San Carlos医院（马德里，西班牙）转介。该队列将分为两组(干预组，其中SAM干预将作为标准治疗的辅助手段；另一组是正常治疗组)。将对自杀行为和精神症状的危险因素进行多达四次的广泛临床评估：基线、后（5周）、3个月和6个月。数据收集正在进行中。本研究将提供有关SAM干预在减少意念、预防自杀企图发生和减轻情绪症状（如焦虑和抑郁）方面的有效性的数据。

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引用次数: 0

Genetic evidence of increased schizophrenia risk due to antidepressant use in European and East Asian populations 欧洲和东亚人群使用抗抑郁药导致精神分裂症风险增加的遗传证据

IF 2.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-04-01 Epub Date: 2025-03-01 DOI: 10.1016/j.ejpsy.2025.100302

Zhiqiang Du , Xiangjun Zhou , Qin Zhou, Rongrong Lu, Ying Jiang, Haohao Zhu

Background and objectives

Understanding the relationship between antipsychotic drugs (ATDs) use and schizophrenia (SCZ) is crucial. Thus, the objective is to explore the bidirectional causal relationship between ATDs use and SCZ via Two-Sample Mendelian Randomization (TSMR) analysis, aiming to offer new insights for the clinical treatment of SCZ.

Methods

We employed data from Genome-Wide Association Studies (GWAS) and conducted TSMR analysis using the Inverse Variance Weighted (IVW) method. The results were evaluated using P-values, OR values, and 95% Confidence Intervals (95% CI) to assess the bidirectional causal relationship.

Results

At the genetic level, we found a bidirectional positive correlation between European ATDs use and SCZ [OR: 1.283, 95% CI: 1.136–1.449; P = 5.73E-05] and [OR: 1.130, 95% CI: 1.082–1.180; P = 4.27E-08]. East Asian ATDs use and SCZ also showed a positive correlation [OR: 1.174, 95% CI: 1.038–1.328; P = 0.011], while no significant causal relationship was found between East Asian SCZ and ATDs use [OR: 1.004, 95% CI: 0.999–1.009; P = 0.161]. Sensitivity analysis further supported the robustness and reliability of these findings.

Conclusion

At the genetic level, we found that European and East Asian ATDs use may increase the risk of developing SCZ. This can help in formulating clinical medication strategies, where more caution may be needed in deciding whether to prescribe ATDs to SCZ patients. Additionally, we discovered that European SCZ might increase ATDs use, whereas no such risk was found in East Asians.

背景与目的了解抗精神病药物（ATDs）使用与精神分裂症（SCZ）之间的关系至关重要。因此，我们的目的是通过双样本孟德尔随机化（TSMR）分析，探讨ATDs使用与SCZ之间的双向因果关系，旨在为SCZ的临床治疗提供新的见解。方法采用全基因组关联研究（GWAS）数据，采用逆方差加权（IVW）方法进行TSMR分析。使用p值、OR值和95%置信区间（95% CI）对结果进行评估，以评估双向因果关系。结果在遗传水平上，我们发现欧洲人使用ATDs与SCZ呈双向正相关[OR: 1.283, 95% CI: 1.136-1.449；P = 5.73E-05]和[OR: 1.130, 95% CI: 1.082-1.180；P = 4.27e-08]。东亚地区ATDs使用与SCZ也呈正相关[OR: 1.174, 95% CI: 1.038 ~ 1.328；P = 0.011]，而东亚SCZ与ATDs使用无显著因果关系[OR: 1.004, 95% CI: 0.999-1.009；P = 0.161]。敏感性分析进一步支持了这些发现的稳健性和可靠性。结论在遗传水平上，我们发现欧洲和东亚使用ATDs可能增加SCZ发生的风险。这有助于制定临床用药策略，在决定是否给SCZ患者开ATDs时可能需要更加谨慎。此外，我们发现欧洲SCZ可能会增加ATDs的使用，而东亚人没有发现这种风险。

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引用次数: 0

Scale to measure dialectical thinking from dialectical behavior therapy perspective. 从辩证行为治疗的角度衡量辩证思维的量表。

IF 2.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-04-01 Epub Date: 2025-03-21 DOI: 10.1016/j.ejpsy.2025.100305

Joaquim Soler , Maria Arqueros , Carlos Schmidt , Daniela Otero , Anna Soria-Madrid , María José Campins , Anna Catalan , Elisabet Casellas , Rocío Espeso , Juan Carlos Pascual

Background and Objectives

Dialectical thinking is a core component of dialectical behavior therapy (DBT), characterized by the synthesis of seemingly opposing ideas to develop a more comprehensive perspective. This study aimed to create a reliable and valid instrument for measuring dialectical thinking.

Method

We analyzed the psychometric properties of the Dialectical Thinking Scale in a mixed sample of 205 participants. Factor structure with both exploratory and confirmatory factor analyses, reliability, test-retest stability, sensitivity to change, and convergent validity were evaluated.

Results

The final resulting questionnaire consisted of a 5-item self-reported scale. The analyses revealed a distinct two-factor structure: "Both Sides" (the capacity to recognize and accept opposing perspectives as simultaneously valid, thereby fostering cognitive flexibility and reducing polarized thinking) and "Both Sides in Me" (the ability to integrate and accept internal contradictions). The scale exhibited high internal consistency (Cronbach's alpha = 0.81), and robust test-retest reliability (ICC = 0.82 for "Both Sides" and 0.64 for "Both Sides in Me"). The scale demonstrated satisfactory sensitivity to change after psychotherapeutic intervention and showed significant negative correlations with psychopathological symptoms.

Conclusions

This scale addresses a critical gap in clinical assessment tools for DBT and it holds promise for applications across mental disorders and social studies.

背景与目的辩证思维是辩证行为疗法（DBT）的核心组成部分，其特点是将看似对立的观点综合起来，形成更全面的视角。本研究旨在建立一种可靠有效的辩证思维测量工具。方法采用205人的混合样本，对辩证思维量表的心理测量特征进行分析。采用探索性和验证性因子分析评估因子结构、信度、重测稳定性、变化敏感性和收敛效度。结果最终问卷由5项自述量表组成。分析揭示了一个明显的双因素结构：“两面”（认识和接受对立观点同时有效的能力，从而促进认知灵活性和减少两极分化的思维）和“两面在我”（整合和接受内部矛盾的能力）。量表具有较高的内部一致性（Cronbach's alpha = 0.81）和稳健的重测信度（“双方”的ICC = 0.82，“我的双方”的ICC = 0.64）。该量表对心理治疗干预后的变化具有满意的敏感性，且与精神病理症状呈显著负相关。结论：该量表填补了DBT临床评估工具的一个关键空白，并有望在精神障碍和社会研究领域得到应用。

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引用次数: 0

Loneliness as a risk factor for dementia and its mediators: A longitudinal cohort analysis of UK Biobank data 孤独作为痴呆的风险因素及其中介：英国生物银行数据的纵向队列分析

IF 2.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-04-01 Epub Date: 2024-12-17 DOI: 10.1016/j.ejpsy.2024.100284

Marine Echegut , Natalie Shoham , Naaheed Mukadam

Background and objectives

Growing evidence suggests that the feeling of loneliness correlates positively with the incidence of dementia, motivating our study of their longitudinal association. Additionally, we sought potential mediators of the association, following the hypotheses that lonely individuals are prone to greater stress and follow less healthy lifestyles, therefore are at greater risk of developping dementia.

Methods

Using longitudinal cohort data from the UK Biobank, we conducted a logistic regression analysis with loneliness as exposure and dementia diagnosis as outcome, and progressively adjusted for putative confounders. In addition, we investigated through mediation models the respective contributions of physiological and behavioural factors to the association between loneliness and dementia diagnosis.

Results

The logistic regression models illustrated a significant positive association between loneliness and a subsequent dementia diagnosis, overall indicating a higher odds of developing dementia in the lonely population (Adjusted Odds Ratio (AOR) = 1.39; 95 % (Confidence Interval) CI 1.24 – 1.56, P < 0.001). The mediation models highlighted that there was very little evidence of mediation by hypertension and unhealthy behaviours, respectively explaining 1 % and 2 % of the effect of loneliness on dementia risk. No indication of mediation was seen between baseline CRP-levels and all-cause dementia. Every mediation model described a positive correlation between loneliness and each potential mediating factor, illustrating the widespread negative impact of loneliness on health.

Conclusion

Our findings confirm the association between loneliness and risk of dementia. They show minimal mediation by hypertension and unhealthy behaviours, highlighting the need for investigation into other potential mediators as targets for modification.

背景和目的越来越多的证据表明，孤独感与痴呆的发病率呈正相关，这促使我们对它们之间的纵向关联进行研究。此外，我们寻找了这种关联的潜在中介，假设孤独的人容易承受更大的压力，生活方式不太健康，因此患痴呆症的风险更大。方法使用来自英国生物银行的纵向队列数据，我们进行了logistic回归分析，以孤独为暴露，痴呆诊断为结果，并逐步调整假定的混杂因素。此外，我们还通过中介模型探讨了生理和行为因素在孤独与痴呆诊断之间的作用。结果logistic回归模型显示孤独与随后的痴呆诊断之间存在显著正相关，总体上表明孤独人群患痴呆的几率更高(调整优势比(AOR) = 1.39；95%（置信区间）CI 1.24 - 1.56, P <；0.001)。中介模型强调，高血压和不健康行为的中介证据非常少，分别解释了孤独对痴呆风险影响的1%和2%。没有迹象表明基线crp水平与全因痴呆之间存在中介作用。每个中介模型都描述了孤独与每个潜在中介因素之间的正相关关系，说明了孤独对健康的广泛负面影响。结论：我们的研究结果证实了孤独感与痴呆风险之间的联系。它们显示高血压和不健康行为的调解作用最小，强调需要调查其他潜在的调解作为修改的目标。

{"title":"Loneliness as a risk factor for dementia and its mediators: A longitudinal cohort analysis of UK Biobank data","authors":"Marine Echegut , Natalie Shoham , Naaheed Mukadam","doi":"10.1016/j.ejpsy.2024.100284","DOIUrl":"10.1016/j.ejpsy.2024.100284","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Growing evidence suggests that the feeling of loneliness correlates positively with the incidence of dementia, motivating our study of their longitudinal association. Additionally, we sought potential mediators of the association, following the hypotheses that lonely individuals are prone to greater stress and follow less healthy lifestyles, therefore are at greater risk of developping dementia.</div></div><div><h3>Methods</h3><div>Using longitudinal cohort data from the UK Biobank, we conducted a logistic regression analysis with loneliness as exposure and dementia diagnosis as outcome, and progressively adjusted for putative confounders. In addition, we investigated through mediation models the respective contributions of physiological and behavioural factors to the association between loneliness and dementia diagnosis.</div></div><div><h3>Results</h3><div>The logistic regression models illustrated a significant positive association between loneliness and a subsequent dementia diagnosis, overall indicating a higher odds of developing dementia in the lonely population (Adjusted Odds Ratio (AOR) = 1.39; 95 % (Confidence Interval) CI 1.24 – 1.56, <em>P</em> < 0.001). The mediation models highlighted that there was very little evidence of mediation by hypertension and unhealthy behaviours, respectively explaining 1 % and 2 % of the effect of loneliness on dementia risk. No indication of mediation was seen between baseline CRP-levels and all-cause dementia. Every mediation model described a positive correlation between loneliness and each potential mediating factor, illustrating the widespread negative impact of loneliness on health.</div></div><div><h3>Conclusion</h3><div>Our findings confirm the association between loneliness and risk of dementia. They show minimal mediation by hypertension and unhealthy behaviours, highlighting the need for investigation into other potential mediators as targets for modification.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 2","pages":"Article 100284"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Screening time for delirium in dementia patients matters: Validation of the Spanish version of the RADAR 痴呆患者谵妄的筛查时间：西班牙语版RADAR的验证

IF 2.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-04-01 Epub Date: 2024-12-20 DOI: 10.1016/j.ejpsy.2024.100272

Esteban Sepúlveda , Ester Bermúdez , Lourdes Vallinoto , Julia Sánchez , Paola Saura , Pau Piany , Eva Viñuelas , Marta Ciutat , José Palma , Imma Grau , Elisabet Vilella , Philippe Voyer , José G. Franco

Background and objectives

Delirium is frequently underdiagnosed in patients with dementia. The Repérage Actif du Delirium Adapté à la Routine (RADAR) can be adapted to nursing routines for delirium screening. We validated the Spanish RADAR version and determined the best time of day for its administration.

Methods

All dementia patients admitted to a postacute care centre on one day were independently assessed by nurses using the RADAR at the morning and midday and by geriatricians with the Delirium Diagnostic Tool-Provisional (DDT-Pro) reference standard for delirium and subsyndromal delirium (SSD). We evaluated the test–retest temporal stability of the morning and midday RADAR assessments, the RADAR validity considering these two time points and then, the suitability of the DDT-Pro for diagnostic confirmation.

Results

Of 34 dementia patients included, 47.1 % had delirium, and 83.3 % had behavioural, mental or neurological disturbances that made diagnostic assessment difficult. The test–retest temporal stability of the RADAR was moderate, which is consistent with the fact that the diagnostic accuracy of the midday assessment for delirium (79.4 %) was better than that of the morning (73.5 %). The screening accuracy when also considering SSD, accounting for either assessment time, was 79.4 %. Several correspondence and correlation analyses support the use of DDT-Pro for confirmation and assessment of delirium severity after RADAR screening.

Conclusion

The RADAR is useful for the screening of delirium and SSD by nurses in dementia patients and midday assessments have greater diagnostic validity than morning assessments. Screened patients need subsequent diagnosis confirmation before starting therapeutic measures.

背景与目的谵妄常被误诊为痴呆患者。雷达（RADAR）可适用于谵妄筛查的护理程序。我们验证了西班牙雷达版本，并确定了一天中管理它的最佳时间。方法所有急性后护理中心收治的痴呆患者均由护士在上午和中午使用RADAR进行独立评估，老年医师使用谵妄诊断工具-临时（DDT-Pro）谵妄和亚综合征性谵妄（SSD）参考标准进行评估。我们评估了早晨和中午RADAR评估的重测时间稳定性，考虑这两个时间点的RADAR效度，然后评估了DDT-Pro诊断确认的适用性。结果34例痴呆患者中，47.1%有谵妄，83.3%有行为、精神或神经障碍，使诊断评估困难。RADAR的重测时间稳定性中等，这与中午评估谵妄的诊断准确率（79.4%）优于早晨评估谵妄的诊断准确率（73.5%）是一致的。同时考虑SSD的筛查准确率为79.4%。一些对应和相关分析支持使用DDT-Pro来确认和评估雷达筛查后谵妄严重程度。结论RADAR可用于痴呆患者谵妄和SSD的筛查，午间评估的诊断效度高于晨间评估。筛查的患者需要在开始治疗措施之前进行诊断确认。

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引用次数: 0

Identification of a linoleic acid derivative in elderly female patients with schizophrenia from rural regions using untargeted metabolomics 利用非靶向代谢组学方法鉴定农村地区老年女性精神分裂症患者的亚油酸衍生物

IF 2.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-04-01 Epub Date: 2024-12-17 DOI: 10.1016/j.ejpsy.2024.100285

Bo Pan , Li Qu , Chuan-Lan Wang , Jianjun Weng , Jian-Feng Yu , Yanqing Liu , Xing-Chen Wang

Background and objectives

Schizophrenia is a chronic and severe mental illness, affecting a large number of general populations. It was well documented that metabolic dysregulation is associated with schizophrenia. In order to define reliable peripheral biomarkers for schizophrenia in patients with specific age, sex, and locations, plasma metabolic profiling of elderly female schizophrenic patients in rural regions was investigated in this study.

Methods

A total of 20 female schizophrenic patients (average age: 68.65 ± 4.11) and 20 matched healthy controls were recruited. An untargeted metabolomics analysis was performed with their plasma samples of the participants. Differentially-expressed metabolites (DEMs) were identified, followed by a pathway enrichment analysis to reveal related signalling pathways. Then, machine learning analyses, including random forest (RF) and support vector machines-recursive feature elimination (SVM-RFE), were implemented to determine signature metabolite(s).

Results

A total number of 2764 metabolites were identified, among which 61 DEMs were identified, including 38 down-regulated and 23 up-regulated metabolites. The enrichment analysis showed that glycerophospholipid metabolism and sphingolipid signalling pathway were the most significantly affected pathways. The ROC analysis indicated that metabolites belonging to the class of fatty acyls have higher power to discriminate schizophrenia. Finally, a linoleic acid derivative (Dg(16:0/18:2(9z,12z)/0:0)[Iso2]) was revealed as signature metabolite by the RF and SVM-RFE machine learning analyses.

Conclusion

The present study investigated the plasma metabolic profiling of elderly female patients with schizophrenia and identified a peripheral linoleic acid derivative that might help discriminate schizophrenia and develop specific treatment strategies for elderly female patients in rural regions.

背景与目的精神分裂症是一种影响广大人群的慢性重症精神疾病。代谢失调与精神分裂症有关是有充分证据证明的。为了确定具有特定年龄、性别和地区的精神分裂症患者的可靠外周生物标志物，本研究调查了农村地区老年女性精神分裂症患者的血浆代谢谱。方法选取20例女性精神分裂症患者（平均年龄：68.65±4.11岁）和20例健康对照。对参与者的血浆样本进行了非靶向代谢组学分析。鉴定了差异表达代谢物（DEMs），随后进行途径富集分析以揭示相关信号通路。然后，通过机器学习分析，包括随机森林（RF）和支持向量机递归特征消除（SVM-RFE），来确定特征代谢物。结果共鉴定出2764种代谢物，其中dem 61种，其中下调代谢物38种，上调代谢物23种。富集分析表明，甘油磷脂代谢和鞘脂信号通路受影响最显著。ROC分析表明，属于脂肪酰基类的代谢物具有更高的区分精神分裂症的能力。最后，通过RF和SVM-RFE机器学习分析，发现亚油酸衍生物Dg(16:0/18:2(9z,12z)/0:0)[Iso2]是特征代谢物。结论本研究对老年女性精神分裂症患者的血浆代谢谱进行了研究，发现了一种外周亚油酸衍生物，可能有助于区分精神分裂症，并为农村地区老年女性患者制定特异性治疗策略。

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引用次数: 0

Adaptation and validation of the inventory of psychotic-like anomalous self-experiences (IPASE) into spanish to assess anomalous self-experiences 精神病样异常自我体验量表（IPASE）在西班牙语中的改编与验证以评估异常自我体验

IF 2.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-04-01 Epub Date: 2024-12-25 DOI: 10.1016/j.ejpsy.2024.100276

Marta Hernández-García , Rosa M. Beño-Ruiz-de-la-Sierra , José Luis Quintana-Velasco , Inés Fernández-Linsenbarth , Olga Santesteban-Echarri , Vicente Molina Rodríguez

Background and objectives

Anomalous self-experience, or the experience of the self, are frequently present but underexplored in patients with schizophrenia. Unfortunately, to date, there are no available inventories in Spanish to assess these self-experiences. The present study aims to adapt and validate the Inventory of Psychotic-Like Anomalous Self-Experiences (IPASE) in the Spanish population.

Methods

A total of 171 participants were included: 112 cases (patients) and 59 healthy controls. Among them, 87 patients were diagnosed with schizophrenia (70 chronic and 17 first-episode patients) and 25 patients with bipolar disorder. The participants were evaluated using the structured clinical interview DSM-IV and were tasked with completing the Spanish version of the IPASE. The properties of the scale were analysed in terms of internal consistency, stability, and correlation between scores on the subscales with sociodemographic and clinical variables.

Results

The IPASE showed good reliability (Cronbach's alpha coefficient of 0.847) and intraclass correlation,with a value of 0.837 for the patient group and 0.812 for the control group. The variables of age and sex did not significantly correlate with the total IPASE score. Compared to healthy controls, cases obtained significantly higher overall scores on the IPASE and its five subscales; total scores on the IPASE (Cases: (20.96 ± 42.5)vs. control:(80.56 ± 20.6), p < 0.001).

Conclusions

The Spanish version of the IPASE scale shows good psychometric properties in terms of reliability and validity for its application in assessing alterations in subjective self-experiences in patients with schizophrenia. This demonstrates the value of the IPASE as a tool in both clinical practice and research.

背景与目的异常的自我体验或自我体验在精神分裂症患者中经常出现，但尚未得到充分的研究。不幸的是，到目前为止，还没有可用的西班牙语清单来评估这些自我体验。本研究的目的是适应和验证的清单精神病样异常自我经验（IPASE）在西班牙人口。方法共171例受试者：112例（患者）和59例健康对照。其中87例患者被诊断为精神分裂症（70例慢性，17例首发），25例患者被诊断为双相情感障碍。参与者使用结构化临床访谈DSM-IV进行评估，并完成西班牙语版IPASE。量表的性质根据内部一致性、稳定性以及各子量表得分与社会人口学和临床变量之间的相关性进行了分析。结果IPASE具有良好的信度（Cronbach’s alpha系数为0.847）和类内相关性，其中患者组为0.837，对照组为0.812。年龄和性别变量与IPASE总分无显著相关。与健康对照相比，病例在IPASE及其五个分量表上获得了显著更高的总分；IPASE总分(病例：（20.96±42.5）vs。对照组：（80.56±20.6），p <；0.001)。结论西班牙语版IPASE量表在评估精神分裂症患者主观自我体验改变方面具有良好的信度和效度。这证明了IPASE作为临床实践和研究工具的价值。

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引用次数: 0

Development of the Spanish version of the Parents' Self-Stigma Scale 西班牙语版父母自我耻辱感量表的编制

IF 2.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-04-01 Epub Date: 2024-12-24 DOI: 10.1016/j.ejpsy.2024.100275

Andreu Nolasco , Giovanna Tassara , Laura Borredà , Manuel Giron , Nayara Tamayo-Fonseca , Joaquín Moncho , Pamela Pereyra-Zamora , Manuel Gómez-Beneyto

Background and Objectives

It is known that those who regularly interact with people with mental illness, such as family members, caregivers and mental health professionals, can be subjected to public stigmatization and that they may eventually develop self-stigmatization. Despite the relevance of parental self-stigma for the upbringing and treatment of children with psychiatric problems, only one instrument has been developed to identify it, the Parents' Self-Stigma Scale (PSSS). The lack of a similar instrument in Spanish motivated the present study, with the aim of developing a Spanish version of the PSSS.

Methods

After translating the PSSS, it was administered to two samples of parents of children who were treated consecutively in child-adolescent mental health centres in Reus and Valencia. The Reus sample was subjected to Exploratory Factor Analysis (EFA) and the Valencia sample to Confirmatory Factor Analysis (CFA), taking as reference the factor load matrix obtained in Reus. Temporal stability was estimated by calculating the ICC between the results obtained in two administrations of the questionnaire separated by four weeks. To estimate convergent validity, the correlation of the questionnaire score with the scores of the Rosenberg Self-Esteem Scale and the Schwarzer General Self-Efficacy Scale was calculated.

Results

The EFA showed the existence of three factors, “Bad Father”, “Self-blame” and “Self-shame”, which confirms the structural equivalence of the Spanish version and the original PSSS. Likewise, it was confirmed that the Spanish version is temporarily stable and valid.

Conclusions

The results obtained show that the Spanish version of the PSSS is semantically and psychometrically equivalent to the original PSSS, and that it has acceptable temporal stability and convergent validity.

背景和目的众所周知，那些经常与精神疾病患者互动的人，如家庭成员、照顾者和精神卫生专业人员，可能会受到公众的污名化，并最终可能产生自我污名化。尽管父母自我耻辱感与儿童精神问题的养育和治疗相关，但只有一种工具被开发出来识别它，即父母自我耻辱感量表（PSSS）。由于缺乏西班牙语的类似工具，因此开展了本研究，目的是开发西班牙语版的PSSS。方法对在罗伊斯和瓦伦西亚儿童-青少年心理健康中心连续接受治疗的儿童的父母进行PSSS翻译。以Reus的因子负荷矩阵为参考，对Reus样品进行探索性因子分析（Exploratory Factor Analysis， EFA），对Valencia样品进行验证性因子分析（Confirmatory Factor Analysis， CFA）。通过计算间隔四周的两次问卷调查结果之间的ICC来估计时间稳定性。为了估计收敛效度，计算问卷得分与Rosenberg自尊量表和Schwarzer一般自我效能量表得分的相关关系。结果EFA显示“坏父亲”、“自责”和“羞耻感”三个因素的存在，证实了西班牙语版与原PSSS在结构上的等价性。同样，西班牙语版本暂时稳定有效。结论西班牙语版PSSS在语义和心理计量学上与原PSSS相当，具有可接受的时间稳定性和收敛效度。

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引用次数: 0

"Fluctuations in mental health symptoms from recruitment to baseline: implications for eligibility in clinical trials" "从招募到基线期间心理健康症状的波动：对临床试验资格的影响"

IF 2.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry

Pub Date : 2025-04-01 Epub Date: 2025-03-14 DOI: 10.1016/j.ejpsy.2025.100306

Juliane Piasssechi de Bernardin Gonçalves , Homero Vallada , Giancarlo Lucchetti

引用次数: 0