Pub Date : 2023-12-02DOI: 10.1016/j.ejpsy.2023.100231
Pingyuan Yang, Jiajun Weng, Xiao Huang
Background and objectives
Alcohol use disorder (AUD) is often linked to sleep problems, but previous studies on sleep abnormalities in AUD have produced inconsistent results. This study aims to provide a comprehensive analysis of objectively measured sleep abnormalities in AUD and determine the impact of related and demographic factors on sleep disturbance.
Methods
We conducted a comprehensive search of several databases from 1968 to 2023 to identify relevant studies. A total of 12 studies, consisting of 13 datasets, were included in the analysis. We extracted information on sleep microarchitecture, as well as demographic and clinical features, from each study. The GRADE approach was used to assess the reliability and strength of the evidence.
Results
Patients with AUD exhibited several sleep abnormalities, including longer sleep onset latency, lower sleep efficiency, increased stage 1 sleep, decreased stage 2 sleep, reduced slow wave sleep, and elevated rapid eye movement (REM) sleep density and first REM minute. The sleep patterns in individuals with AUD were also influenced by factors such as ethnicity, age, gender, and abstinence period.
Conclusions
This study is the largest quantitative assessment of impaired sleep as a diagnostic marker in patients with AUD. Understanding the sleep patterns of individuals with AUD can assist clinicians in developing effective treatment plans for managing sleep-related symptoms associated with AUD.
{"title":"Sleep features in alcohol use disorder: A systematic review and meta-analysis of polysomnographic findings in case-control studies","authors":"Pingyuan Yang, Jiajun Weng, Xiao Huang","doi":"10.1016/j.ejpsy.2023.100231","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.100231","url":null,"abstract":"<div><h3>Background and objectives</h3><p>Alcohol use disorder (AUD) is often linked to sleep problems, but previous studies on sleep abnormalities in AUD have produced inconsistent results. This study aims to provide a comprehensive analysis of objectively measured sleep abnormalities in AUD and determine the impact of related and demographic factors on sleep disturbance.</p></div><div><h3>Methods</h3><p>We conducted a comprehensive search of several databases from 1968 to 2023 to identify relevant studies. A total of 12 studies, consisting of 13 datasets, were included in the analysis. We extracted information on sleep microarchitecture, as well as demographic and clinical features, from each study. The GRADE approach was used to assess the reliability and strength of the evidence.</p></div><div><h3>Results</h3><p>Patients with AUD exhibited several sleep abnormalities, including longer sleep onset latency<span>, lower sleep efficiency, increased stage 1 sleep, decreased stage 2 sleep, reduced slow wave sleep, and elevated rapid eye movement (REM) sleep density and first REM minute. The sleep patterns in individuals with AUD were also influenced by factors such as ethnicity, age, gender, and abstinence period.</span></p></div><div><h3>Conclusions</h3><p>This study is the largest quantitative assessment of impaired sleep as a diagnostic marker in patients<span> with AUD. Understanding the sleep patterns of individuals with AUD can assist clinicians in developing effective treatment plans for managing sleep-related symptoms associated with AUD.</span></p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"38 2","pages":"Article 100231"},"PeriodicalIF":1.8,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138475381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-09DOI: 10.1016/j.ejpsy.2023.100227
Hugo J. Bello , Nora Palomar-Ciria , Celia Lozano , Carlos Gutiérrez-Alonso , Enrique Baca-García
Background and objectives
Suicide is a major public health concern, media can influence its awareness, contagion, and prevention. In this study, we evaluated the relationship between the COVID-19 pandemic and suicide in media coverage through Natural Language Processing analysis (NPL).
Methods
To study how suicide is depicted in news media, Artificial Intelligence and Big Data techniques were used to analyze news and tweets, to extract or classify the topic to which they belonged.
Results
A granger causality analysis showed with significant p-value that an increase in covid news at the beginning of the pandemic explains a later rise in suicide-related news. An analysis based on correlation and structural causal models show a strong relationship between the appearance of subjects “health” and “covid”, and also between “covid” and “suicide”.
Conclusions
Our analysis also uncovers that the inclusion of suicide-related news in the category health has grown since the outbreak of the pandemic. The COVID-19 pandemic has posed an inflection point in the way suicide-related news are reported. Our study found that the increased media attention on suicide during the COVID-19 pandemic may indicate rising social awareness of suicide and mental health, which could lead to the development of new prevention tools.
{"title":"Examining the relationship between COVID-19 and suicide in media coverage through Natural Language Processing analysis","authors":"Hugo J. Bello , Nora Palomar-Ciria , Celia Lozano , Carlos Gutiérrez-Alonso , Enrique Baca-García","doi":"10.1016/j.ejpsy.2023.100227","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.100227","url":null,"abstract":"<div><h3>Background and objectives</h3><p>Suicide is a major public health concern, media can influence its awareness, contagion, and prevention. In this study, we evaluated the relationship between the COVID-19 pandemic and suicide in media coverage through Natural Language Processing analysis (NPL).</p></div><div><h3>Methods</h3><p>To study how suicide is depicted in news media, Artificial Intelligence and Big Data techniques were used to analyze news and tweets, to extract or classify the topic to which they belonged.</p></div><div><h3>Results</h3><p>A granger causality analysis showed with significant <em>p</em>-value that an increase in <em>covid</em> news at the beginning of the pandemic explains a later rise in suicide-related news. An analysis based on correlation and structural causal models show a strong relationship between the appearance of subjects “health” and “covid”, and also between “covid” and “suicide”.</p></div><div><h3>Conclusions</h3><p>Our analysis also uncovers that the inclusion of suicide-related news in the category health has grown since the outbreak of the pandemic. The COVID-19 pandemic has posed an inflection point in the way suicide-related news are reported. Our study found that the increased media attention on suicide during the COVID-19 pandemic may indicate rising social awareness of suicide and mental health, which could lead to the development of new prevention tools.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"38 1","pages":"Article 100227"},"PeriodicalIF":1.8,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study explored the correlation between nonsuicidal self-injury (NSSI) and family functioning among adolescents aged 12 to 17 years with mood disorders.
Methods
A total of 142 participants were clinically assessed for NSSI, with 85 in the NSSI group and 57 in the non-NSSI group. The correlation between NSSI and family functioning was compared and a regression prediction model was constructed to determine the risk probability of NSSI.
Results
A significant association was found between family functioning and NSSI (P = 0.017). The correlation between adolescents with NSSI and gender, communication, affective responsiveness, and behaviour control was statistically significant. A nomogram graph and ROC curve were constructed, with an AUC of 0.772.
Conclusion
The findings support the notion that family functioning is associated with a higher risk for NSSI among adolescents with mood disorders. Furthermore, gender, communication, affective responsiveness, and behaviour control may be contributing factors.
{"title":"An exploration of the association between family functioning and nonsuicidal self-injury among Chinese adolescents with mood disorders","authors":"Changyuan Qiao , Jian Lin , Jialing Huang , Linqi Zhou , Yanchao Huang , Yushan Shang , Qixiu Zhang , Jian Xie , Changchun Hu","doi":"10.1016/j.ejpsy.2023.100226","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.100226","url":null,"abstract":"<div><h3>Background and objectives</h3><p>This study explored the correlation between nonsuicidal self-injury (NSSI) and family functioning among adolescents aged 12 to 17 years with mood disorders.</p></div><div><h3>Methods</h3><p>A total of 142 participants were clinically assessed for NSSI, with 85 in the NSSI group and 57 in the non-NSSI group. The correlation between NSSI and family functioning was compared and a regression prediction model was constructed to determine the risk probability of NSSI.</p></div><div><h3>Results</h3><p>A significant association was found between family functioning and NSSI (<em>P</em> = 0.017). The correlation between adolescents with NSSI and gender, communication, affective responsiveness, and behaviour control was statistically significant. A nomogram graph and ROC curve were constructed, with an AUC of 0.772.</p></div><div><h3>Conclusion</h3><p>The findings support the notion that family functioning is associated with a higher risk for NSSI among adolescents with mood disorders. Furthermore, gender, communication, affective responsiveness, and behaviour control may be contributing factors.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"38 1","pages":"Article 100226"},"PeriodicalIF":1.8,"publicationDate":"2023-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-07DOI: 10.1016/j.ejpsy.2023.100228
S. Lundqvist , N. Kerekes
Background and objectives
The relationship between pain and psychiatric conditions in children and adolescents has been understudied. This study aimed to investigate the influence of gender on the association between pain and psychiatric diagnoses, as well as the specific relationship between pain and attention deficit/hyperactivity disorder (ADHD), in a sample of adolescents from the general population. Additionally, the study explored whether pain frequency or intensity in individuals with ADHD was influenced by coexisting psychiatric disorders and ADHD medications.
Methods
This cross-sectional study included 1608 conveniently sampled Swedish upper secondary school students aged 15–19 years. Data were collected at the end of 2020 using the electronic "Mental and Somatic Health without borders" survey.
Results
A significant positive association (p < 0.001) was observed between pain frequency, intensity, and the presence of any psychiatric diagnosis. Female adolescents reported more frequent and intensive pain in the groups with or without any psychiatric diagnosis and in those with ADHD, however the presence of a psychiatric diagnosis had a comparatively lesser impact on pain frequency in females when compared to males. In adolescents with ADHD, pain frequency, but not intensity, showed a significant further increase. Moreover, the presence of coexisting depression and/or anxiety further heightened the association between pain frequency and ADHD. Notably, common ADHD medications did not have a significant impact on pain experiences. Headache emerged as the most prevalent type of pain across all groups of adolescents. Back pain specifically appeared as the next most common type of pain among adolescents with ADHD.
Conclusion
The findings suggest a positive association between pain and the presence of psychiatric diagnoses, including ADHD, in adolescents. Gender modified this association. Back pain arised specifically coupled to ADHD. Common ADHD medications did not show a significant impact on pain experiences in this study. These results highlight the importance of a holistic approach to child and adolescent care.
{"title":"The association between pain and psychiatric conditions in adolescents: The impact of gender and ADHD diagnosis","authors":"S. Lundqvist , N. Kerekes","doi":"10.1016/j.ejpsy.2023.100228","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.100228","url":null,"abstract":"<div><h3>Background and objectives</h3><p>The relationship between pain and psychiatric conditions in children and adolescents has been understudied. This study aimed to investigate the influence of gender on the association between pain and psychiatric diagnoses, as well as the specific relationship between pain and attention deficit/hyperactivity disorder (ADHD), in a sample of adolescents from the general population. Additionally, the study explored whether pain frequency or intensity in individuals with ADHD was influenced by coexisting psychiatric disorders and ADHD medications.</p></div><div><h3>Methods</h3><p>This cross-sectional study included 1608 conveniently sampled Swedish upper secondary school students aged 15–19 years. Data were collected at the end of 2020 using the electronic \"Mental and Somatic Health without borders\" survey.</p></div><div><h3>Results</h3><p>A significant positive association (<em>p</em> < 0.001) was observed between pain frequency, intensity, and the presence of any psychiatric diagnosis. Female adolescents reported more frequent and intensive pain in the groups with or without any psychiatric diagnosis and in those with ADHD, however the presence of a psychiatric diagnosis had a comparatively lesser impact on pain frequency in females when compared to males. In adolescents with ADHD, pain frequency, but not intensity, showed a significant further increase. Moreover, the presence of coexisting depression and/or anxiety further heightened the association between pain frequency and ADHD. Notably, common ADHD medications did not have a significant impact on pain experiences. Headache emerged as the most prevalent type of pain across all groups of adolescents. Back pain specifically appeared as the next most common type of pain among adolescents with ADHD.</p></div><div><h3>Conclusion</h3><p>The findings suggest a positive association between pain and the presence of psychiatric diagnoses, including ADHD, in adolescents. Gender modified this association. Back pain arised specifically coupled to ADHD. Common ADHD medications did not show a significant impact on pain experiences in this study. These results highlight the importance of a holistic approach to child and adolescent care.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"38 1","pages":"Article 100228"},"PeriodicalIF":1.8,"publicationDate":"2023-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-06DOI: 10.1016/j.ejpsy.2023.100230
O. Oflezer , C. Oflezer , Z.D. Gürbüz , H. Bahadir , Ö.E. Çiçek , E. Kurt
Background and Objectives
Supporting the neurodevelopmental model of schizophrenia, minor physical anomalies (MPAs) are markers of abnormalities in early fetal development. The mouth seems to be a common region for the occurrence of MPAs in patients with schizophrenia. This study aimed to compare the palatal rugae patterns, according to their length, shape, and orientation, between patients with schizophrenia and controls in a blinded fashion. The palatal rugae patterns were also evaluated by sex, as its effect on neurodevelopment was relevant.
Methods
Dental stone models were fabricated from maxilla impressions of patients with schizophrenia (N = 105) and controls (N = 105). Based on their lengths, three types of palatal rugae were classified; primary, secondary, and fragmentary. Primary rugae were further categorized according to their shape and direction.
Results
The most detected palatal rugae were the primary ones in both groups. The primary, secondary, and fragmentary rugae numbers in both groups were no different. There were significant differences in the shape and orientation of the primary rugae between the two groups. Curved (OR:1.76, p = 0.006), island (OR:2.97, p = 0.001) and nonspecific (OR:5.44, p = 0.004) primary rugae shape were found to be significant predictive variables for schizophrenia. Randomly oriented rugae numbers were higher in schizophrenics than controls (p = 0.018). The two sexes had different preferences in primary rugae shapes and directions compared to same-sex controls in patients with schizophrenia.
Conclusion
Identifying subtle changes in the primary rugae pattern, which appear to be sex-specific, is consistent with impaired neurodevelopment in schizophrenia.
{"title":"Is palatal rugae a specific marker of dysmorphogenesis in patients with schizophrenia?","authors":"O. Oflezer , C. Oflezer , Z.D. Gürbüz , H. Bahadir , Ö.E. Çiçek , E. Kurt","doi":"10.1016/j.ejpsy.2023.100230","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.100230","url":null,"abstract":"<div><h3>Background and Objectives</h3><p><span>Supporting the neurodevelopmental model of schizophrenia, minor physical anomalies (MPAs) are markers of abnormalities in early fetal development. The mouth seems to be a common region for the occurrence of MPAs </span>in patients<span><span> with schizophrenia. This study aimed to compare the palatal rugae patterns, according to their length, shape, and orientation, between patients with schizophrenia and controls in a blinded fashion. The palatal rugae patterns were also evaluated by sex, as its effect on </span>neurodevelopment was relevant.</span></p></div><div><h3>Methods</h3><p><span>Dental stone models were fabricated from maxilla impressions of patients with schizophrenia (</span><em>N</em> = 105) and controls (<em>N</em> = 105). Based on their lengths, three types of palatal rugae were classified; primary, secondary, and fragmentary. Primary rugae were further categorized according to their shape and direction.</p></div><div><h3>Results</h3><p>The most detected palatal rugae were the primary ones in both groups. The primary, secondary, and fragmentary rugae numbers in both groups were no different. There were significant differences in the shape and orientation of the primary rugae between the two groups. Curved (OR:1.76, <em>p</em> = 0.006), island (OR:2.97, <em>p</em> = 0.001) and nonspecific (OR:5.44, <em>p</em> = 0.004) primary rugae shape were found to be significant predictive variables for schizophrenia. Randomly oriented rugae numbers were higher in schizophrenics than controls (<em>p</em> = 0.018). The two sexes had different preferences in primary rugae shapes and directions compared to same-sex controls in patients with schizophrenia.</p></div><div><h3>Conclusion</h3><p>Identifying subtle changes in the primary rugae pattern, which appear to be sex-specific, is consistent with impaired neurodevelopment in schizophrenia.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"38 1","pages":"Article 100230"},"PeriodicalIF":1.8,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-06DOI: 10.1016/j.ejpsy.2023.100225
Hurşit Ferahkaya , Ömer Faruk Akça , Tamer Baysal , İbrahim Kılınç
Background and objectives
Accumulating studies have pointed out that gut-blood and blood-brain barrier dysfunctions due to the alterations in permeability may play a role in the pathophysiology of neurodevelopmental disorders. Tight junctions are crucial components of these barriers and some peptides including claudin-5, occludin, zonulin and tricellulin are important components of these structures. This study aimed to investigate the relationship between these molecules and attention deficit hyperactivity disorder (ADHD) in children and adolescents.
Methods
A total of 57 children with ADHD and 60 controls aged between 6 and 12 years were included in the study. The severity of ADHD symptoms was assessed through a parent-rated questionnaire, and Conner's Continuous Performance Test was administered to the study group. Serum levels of biochemical variables were measured using enzyme-linked immunosorbent assay kits. Biochemical parameter levels and scale scores were compared using Mann-Whitney U or Student's t tests. In addition, a multivariate analysis of covariance (MANCOVA) and a one-way analysis of covariance (ANCOVA) was performed on the outcome variables. Finally, a hierarchical regression model was conducted on the study group.
Results
Serum claudin-5 and tricellulin levels were significantly lower in the ADHD group compared to the control group. The difference between the groups in terms of serum claudin-5 and tricellulin levels remained significant after controlling for confounding factors such as age, gender and autistic characteristics. There was no significant difference between the groups in terms of serum zonulin and occludin levels.
Conclusion
These results reveal that claudin-5 and tricellulin levels vary in patients with ADHD. Alterations in these peptides may affect the brain by leading to a dysregulation in intestinal or blood-brain barrier permeability. The causal relationship between these peptides and ADHD requires further investigation.
{"title":"Claudin-5, occludin, zonulin and tricellulin levels of children with attention-deficit/hyperactivity disorder","authors":"Hurşit Ferahkaya , Ömer Faruk Akça , Tamer Baysal , İbrahim Kılınç","doi":"10.1016/j.ejpsy.2023.100225","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.100225","url":null,"abstract":"<div><h3>Background and objectives</h3><p><span>Accumulating studies have pointed out that gut-blood and blood-brain barrier dysfunctions due to the alterations in permeability may play a role in the pathophysiology of neurodevelopmental disorders. Tight junctions are crucial components of these barriers and some peptides including claudin-5, </span>occludin<span>, zonulin and tricellulin are important components of these structures. This study aimed to investigate the relationship between these molecules and attention deficit hyperactivity disorder (ADHD) in children and adolescents.</span></p></div><div><h3>Methods</h3><p>A total of 57 children with ADHD and 60 controls aged between 6 and 12 years were included in the study. The severity of ADHD symptoms was assessed through a parent-rated questionnaire, and Conner's Continuous Performance Test<span> was administered to the study group. Serum levels of biochemical variables were measured using enzyme-linked immunosorbent assay kits. Biochemical parameter levels and scale scores were compared using Mann-Whitney U or Student's t tests<span>. In addition, a multivariate analysis of covariance (MANCOVA) and a one-way analysis of covariance (ANCOVA) was performed on the outcome variables. Finally, a hierarchical regression model was conducted on the study group.</span></span></p></div><div><h3>Results</h3><p>Serum claudin-5 and tricellulin levels were significantly lower in the ADHD group compared to the control group. The difference between the groups in terms of serum claudin-5 and tricellulin levels remained significant after controlling for confounding factors such as age, gender and autistic characteristics. There was no significant difference between the groups in terms of serum zonulin and occludin levels.</p></div><div><h3>Conclusion</h3><p>These results reveal that claudin-5 and tricellulin levels vary in patients with ADHD. Alterations in these peptides may affect the brain by leading to a dysregulation in intestinal or blood-brain barrier permeability. The causal relationship between these peptides and ADHD requires further investigation.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"38 1","pages":"Article 100225"},"PeriodicalIF":1.8,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of this study was to assess the reliability and validity of the Bush Francis Catatonia Screening Instrument and Bush Francis Catatonia Rating Scale Spain Version (BFCSI-SV and BFCRS-SV) using the ICD-11 and DSM-5 diagnostic criteria as well as other catatonia scales.
Methods
One hundred patients were admitted to the inpatient psychiatry unit at Hospital Universitari Germans Trias I Pujol and two psychiatrists administered the BFCRS-SV to the first 10 patients to assess inter-rater reliability. The BFCRS-SV, BFCSI-SV, Modified Rogers Scale (MRS), Abnormal Involuntary Movement Scales, Barnes Akathisia Rating Scale, and Modified Simpson-Angus Scale were then employed.
Results
The results showed that 27% of patients had catatonia using the DSM-5 diagnostic criteria. Additionally, 51% of patients had 2 or more BFCRSI-SV items (Sensitivity: 100%; Specificity: 67.12%). The alpha coefficient values were 0.80 and 0.84 for the BFCSI-SV and BFCRS-SV, respectively, and the intraclass correlation coefficient values were 0.902 and 0.903. The area under the ROC curve was 0.971 and 0.96, and the instruments had a strong positive correlation with the DSM-5 score, ICD-11 score, and MRS. The study identified a three-factor model comprising the inhibition, excitement, and parakinetic dimensions.
Conclusions
Overall, the results suggest that the BFCSI-SV and BFCRS-SV are valid and reliable tools for the diagnosis of catatonia, especially when using a cut-off score of 5 or higher for the BFCSI-SV and 7 or higher for the BFCRS-SV.
背景和目的本研究的目的是使用ICD-11和DSM-5诊断标准以及其他紧张症量表来评估Bush-Francis紧张症筛查仪和Bush-FrancisCatatonia评定量表西班牙版（BFCSI-SV和BFCRS-SV）的可靠性和有效性。方法100名患者被送入德国Trias I Pujol大学医院的住院精神科，两名精神科医生对前10名患者进行BFCRS-SV，以评估评分者之间的可靠性。然后采用BFCRS-SV、BFCSI-SV、改良罗杰斯量表（MRS）、异常非自愿运动量表、Barnes Akathia评定量表和改良Simpson-Angus量表。结果采用DSM-5诊断标准，27%的患者有紧张症。此外，51%的患者有2个或2个以上的BFCRSI-SV项目（敏感性：100%；特异性：67.12%）。BFCSI-SV和BFCRS-SV的α系数值分别为0.80和0.84，组内相关系数值为0.902和0.903。ROC曲线下面积分别为0.971和0.96，仪器与DSM-5评分、ICD-11评分和MRS呈正相关。该研究确定了一个包括抑制、兴奋和副动力学维度的三因素模型。结论总体而言，研究结果表明，BFCSI-SV和BFCRS-SV是诊断紧张症的有效和可靠的工具，尤其是当BFCSI-SV的临界分为5分或更高，BFCRS-SV7分或更高时。
{"title":"Factor analysis and validation of the Bush Francis catatonia rating scale-Spain version","authors":"Jorge Cuevas-Esteban , Francesc Serrat , Luisa Baladon , Neus Rabaneda-Lombarte , Crisanto Díez-Quevedo , Maria Iglesias-González","doi":"10.1016/j.ejpsy.2023.07.004","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.07.004","url":null,"abstract":"<div><h3>Background and objectives</h3><p>The aim of this study was to assess the reliability and validity of the Bush Francis Catatonia Screening Instrument and Bush Francis Catatonia Rating Scale Spain Version (BFCSI-SV and BFCRS-SV) using the ICD-11 and DSM-5 diagnostic criteria as well as other catatonia scales.</p></div><div><h3>Methods</h3><p><span>One hundred patients were admitted to the inpatient psychiatry unit at Hospital Universitari Germans Trias I Pujol and two psychiatrists administered the BFCRS-SV to the first 10 patients to assess inter-rater reliability. The BFCRS-SV, BFCSI-SV, Modified Rogers Scale (MRS), </span>Abnormal Involuntary Movement Scales<span>, Barnes Akathisia Rating Scale, and Modified Simpson-Angus Scale were then employed.</span></p></div><div><h3>Results</h3><p>The results showed that 27% of patients had catatonia using the DSM-5 diagnostic criteria. Additionally, 51% of patients had 2 or more BFCRSI-SV items (Sensitivity: 100%; Specificity: 67.12%). The alpha coefficient values were 0.80 and 0.84 for the BFCSI-SV and BFCRS-SV, respectively, and the intraclass correlation coefficient values were 0.902 and 0.903. The area under the ROC curve was 0.971 and 0.96, and the instruments had a strong positive correlation with the DSM-5 score, ICD-11 score, and MRS. The study identified a three-factor model comprising the inhibition, excitement, and parakinetic dimensions.</p></div><div><h3>Conclusions</h3><p>Overall, the results suggest that the BFCSI-SV and BFCRS-SV are valid and reliable tools for the diagnosis of catatonia, especially when using a cut-off score of 5 or higher for the BFCSI-SV and 7 or higher for the BFCRS-SV.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 4","pages":"Article 100221"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50202018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.1016/j.ejpsy.2023.06.003
Urvashi Panchal , Julio David Vaquerizo-Serrano , Ileana Conde-Ghigliazza , Herdem Aslan Genç , Simone Marchini , Kamile Pociute , Binay Kayan Ocakoğlu , Szarah Sanchez-Roman , Dorottya Ori , Ana Catalan , Luis Alameda , Samuele Cortese , Gonzalo Salazar de Pablo
Background and Objectives
The COVID-19 pandemic and its associated factors have been shown to affect anxiety levels of young people. We meta-analytically assessed the prevalence of anxiety symptoms and anxiety disorders in children and adolescents during the pandemic, and the predictors and moderating factors influencing anxiety.
Methods
Multiple databases and registers were searched in this PRISMA and MOOSE-compliant systematic review and meta-analysis (PROSPERO:CRD42021266695) until 27/06/2021. We included individual studies evaluating the prevalence and characteristics of anxiety symptoms or anxiety disorders in children and adolescents (mean age ≤18 years), during the COVID-19 pandemic. Data extraction and quality assessment were carried out by independent authors. Random-effects meta-analyses of the prevalence of anxiety symptoms and anxiety disorders were conducted using Comprehensive Meta-Analysis (CMA) V3.
Results
74 articles (total participant sample=478,882) were included (mean age=13.4 years, 52.3% female). The pooled rate of children and adolescents fulfilling diagnostic criteria for anxiety disorders was 13.0% (95%CI=4.9–30.1); the pooled prevalence of anxiety symptoms was 26.5% (95%CI=20.3–33.9). Anxiety symptoms were significantly more prevalent in females than males (B = 0.103, p<.001), significantly higher during the second wave of COVID-19, following July 2020, than during the first wave, prior to June 2020, (Q= 8.136, p=.017), and during school closure (Q= 8.100, p=.014). Quality of included studies was overall moderate.
Conclusions
There is a high prevalence of anxiety symptoms in children and adolescents during the COVID-19 pandemic, especially amongst females. This study identifies vulnerable groups, risk, and protective factors, which is crucial to developing clinical practice to prevent further mental health deterioration in young people.
{"title":"Anxiety symptoms and disorders during the COVID-19 pandemic in children and adolescents: Systematic review and meta-analysis","authors":"Urvashi Panchal , Julio David Vaquerizo-Serrano , Ileana Conde-Ghigliazza , Herdem Aslan Genç , Simone Marchini , Kamile Pociute , Binay Kayan Ocakoğlu , Szarah Sanchez-Roman , Dorottya Ori , Ana Catalan , Luis Alameda , Samuele Cortese , Gonzalo Salazar de Pablo","doi":"10.1016/j.ejpsy.2023.06.003","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.06.003","url":null,"abstract":"<div><h3>Background and Objectives</h3><p>The COVID-19 pandemic and its associated factors have been shown to affect anxiety levels of young people. We meta-analytically assessed the prevalence of anxiety symptoms and anxiety disorders in children and adolescents during the pandemic, and the predictors and moderating factors influencing anxiety.</p></div><div><h3>Methods</h3><p>Multiple databases and registers were searched in this PRISMA and MOOSE-compliant systematic review and meta-analysis (PROSPERO:CRD42021266695) until 27/06/2021. We included individual studies evaluating the prevalence and characteristics of anxiety symptoms or anxiety disorders in children and adolescents (mean age ≤18 years), during the COVID-19 pandemic. Data extraction and quality assessment were carried out by independent authors. Random-effects meta-analyses of the prevalence of anxiety symptoms and anxiety disorders were conducted using Comprehensive Meta-Analysis (CMA) V3.</p></div><div><h3>Results</h3><p>74 articles (total participant sample=478,882) were included (mean age=13.4 years, 52.3% female). The pooled rate of children and adolescents fulfilling diagnostic criteria for anxiety disorders was 13.0% (95%CI=4.9–30.1); the pooled prevalence of anxiety symptoms was 26.5% (95%CI=20.3–33.9). Anxiety symptoms were significantly more prevalent in females than males (<em>B</em> = 0.103, <em>p</em><.001), significantly higher during the second wave of COVID-19, following July 2020, than during the first wave, prior to June 2020, (<em>Q</em>= 8.136, <em>p</em>=.017), and during school closure (<em>Q</em>= 8.100, <em>p</em>=.014). Quality of included studies was overall moderate.</p></div><div><h3>Conclusions</h3><p>There is a high prevalence of anxiety symptoms in children and adolescents during the COVID-19 pandemic, especially amongst females. This study identifies vulnerable groups, risk, and protective factors, which is crucial to developing clinical practice to prevent further mental health deterioration in young people.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 4","pages":"Article 100218"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50202017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The association between bipolar disorder (BD) and avascular necrosis of the femoral head and neck (AVNHNF) remains unclear. We aimed to investigate the risk of AVNHNF among different polarity of BD.
Methods
Between 2001 and 2010, patients with BD were selected from the Taiwan National Health Research Database. The controls were individuals without severe mental disorder who were matched for demographic, medical and psychiatric comorbidities. Cox regression analysis was used to estimate the risk of AVNHNF, with adjustments for demographics, comorbidities, exposure to corticosteroids, and all-cause clinical visits.
Results
A total of 84,721 patients with BD and 169,442 controls were included. Patients with BD demonstrated a 1.92-fold (95% of confidence interval: 1.21–3.04) higher risk of AVNHNF compared with the controls. The risk was increased to 7.91-fold (4.32–14.49) in patients with severe BD compared with the controls. Importantly, patients with severe bipolar depression were associated with a 14.23-fold higher risk of AVNHNF compared with the controls, while those with sever bipolar mania were associated with a 3.55-fold higher risk. Compared with the controls with alcohol use disorder (AUD), patients with BD and comorbid AUD were associated with a 2.0-fold higher risk of AVNHNF. Finally, long-term use of atypical antipsychotics was associated with a decreased risk of AVNHNF).
Conclusion
Clinicians should be aware of the increased risk of AVNHNF among patients with BD. This increased risk was associated with disorder severity, polarity, and comorbidity with AUD, and attenuated by long-term atypical antipsychotic treatment.
{"title":"Risk of developing avascular necrosis of the femoral head and neck among patients with bipolar disorder: A nationwide cohort study","authors":"Dian-Jeng Li , Ta-Chuan Yeh , Shih-Jen Tsai , Tzeng-Ji Chen , Chih-Sung Liang , Mu-Hong Chen","doi":"10.1016/j.ejpsy.2023.100224","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.100224","url":null,"abstract":"<div><h3>Background and objectives</h3><p><span>The association between bipolar disorder (BD) and </span>avascular necrosis<span> of the femoral head and neck (AVNHNF) remains unclear. We aimed to investigate the risk of AVNHNF among different polarity of BD.</span></p></div><div><h3>Methods</h3><p>Between 2001 and 2010, patients with BD were selected from the Taiwan National Health Research Database. The controls were individuals without severe mental disorder who were matched for demographic, medical and psychiatric comorbidities. Cox regression analysis was used to estimate the risk of AVNHNF, with adjustments for demographics, comorbidities, exposure to corticosteroids, and all-cause clinical visits.</p></div><div><h3>Results</h3><p>A total of 84,721 patients with BD and 169,442 controls were included. Patients with BD demonstrated a 1.92-fold (95% of confidence interval: 1.21–3.04) higher risk of AVNHNF compared with the controls. The risk was increased to 7.91-fold (4.32–14.49) in patients<span><span> with severe BD compared with the controls. Importantly, patients with severe bipolar depression were associated with a 14.23-fold higher risk of AVNHNF compared with the controls, while those with sever </span>bipolar mania were associated with a 3.55-fold higher risk. Compared with the controls with alcohol use disorder (AUD), patients with BD and comorbid AUD were associated with a 2.0-fold higher risk of AVNHNF. Finally, long-term use of atypical antipsychotics was associated with a decreased risk of AVNHNF).</span></p></div><div><h3>Conclusion</h3><p>Clinicians should be aware of the increased risk of AVNHNF among patients with BD. This increased risk was associated with disorder severity, polarity, and comorbidity with AUD, and attenuated by long-term atypical antipsychotic treatment.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 4","pages":"Article 100224"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50201809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.1016/j.ejpsy.2023.07.002
Lorenzo Pelizza , Emanuela Leuci , Emanuela Quattrone , Silvia Azzali , Giuseppina Paulillo , Simona Pupo , Pietro Pellegrini , Arianna Biancalani , Lorenzo Gammino , Marco Menchetti
Background and Objective
Borderline Personality Disorder (BPD) is under-investigated in First Episode Psychosis (FEP). BPD psychotic manifestations and mood changes are also difficult to differentiate from first episode affective psychosis. The aim of this study was to compare sociodemographic and clinical features between FEP patients with BPD vs. Bipolar Disorder (BD) or Major Depressive Disorder (MDD) both at baseline and across a 2-year follow-up period.
Methods
224 FEP participants (49 with BPD, 93 with BD and 82 with MDD) completed the Health of the Nation Outcome Scale (HoNOS), the Positive And Negative Syndrome Scale (PANSS) and the Global Assessment of Functioning (GAF) scale. Psychiatric diagnosis was reformulated at the end of our follow-up. Inter-group comparisons were analyzed using the Kruskal-Wallis or the Chi-square test. A mixed-design ANOVA model was also performed to assess the temporal stability of clinical scores within and between the 3 subgroups.
Results
Compared to FEP/BD subjects at baseline, FEP/BPD patients showed higher depressive symptom severity and lower excitement severity. Compared to FEP/MDD at entry, they had a higher prevalence rate of substance abuse, a lower interpersonal impairment and a shorter DUP. Finally, they had a lower treatment response on HoNOS “Psychiatric Symptoms” subscale scores across the follow-up in comparison with both FEP/BD and FEP/MDD individuals.
Conclusion
BPD as categorical entity represents a FEP subgroup with specific clinical features and treatment response. Appropriate treatment guidelines for this FEP subgroup are thus needed.
{"title":"Borderline personality disorder vs. mood disorders: clinical comparisons in young people treated within an “Early Intervention” service for first episode psychosis","authors":"Lorenzo Pelizza , Emanuela Leuci , Emanuela Quattrone , Silvia Azzali , Giuseppina Paulillo , Simona Pupo , Pietro Pellegrini , Arianna Biancalani , Lorenzo Gammino , Marco Menchetti","doi":"10.1016/j.ejpsy.2023.07.002","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.07.002","url":null,"abstract":"<div><h3>Background and Objective</h3><p>Borderline Personality Disorder (BPD) is under-investigated in First Episode Psychosis (FEP). BPD psychotic manifestations and mood changes are also difficult to differentiate from first episode affective psychosis. The aim of this study was to compare sociodemographic and clinical features between FEP patients with BPD vs. Bipolar Disorder<span> (BD) or Major Depressive Disorder (MDD) both at baseline and across a 2-year follow-up period.</span></p></div><div><h3>Methods</h3><p><span>224 FEP participants (49 with BPD, 93 with BD and 82 with MDD) completed the Health of the Nation Outcome Scale (HoNOS), the Positive And Negative Syndrome Scale (PANSS) and the </span>Global Assessment of Functioning<span> (GAF) scale. Psychiatric diagnosis was reformulated at the end of our follow-up. Inter-group comparisons were analyzed using the Kruskal-Wallis or the Chi-square test. A mixed-design ANOVA model was also performed to assess the temporal stability of clinical scores within and between the 3 subgroups.</span></p></div><div><h3>Results</h3><p>Compared to FEP/BD subjects at baseline, FEP/BPD patients showed higher depressive symptom severity and lower excitement severity. Compared to FEP/MDD at entry, they had a higher prevalence rate of substance abuse, a lower interpersonal impairment and a shorter DUP. Finally, they had a lower treatment response on HoNOS “Psychiatric Symptoms” subscale scores across the follow-up in comparison with both FEP/BD and FEP/MDD individuals.</p></div><div><h3>Conclusion</h3><p>BPD as categorical entity represents a FEP subgroup with specific clinical features and treatment response. Appropriate treatment guidelines for this FEP subgroup are thus needed.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 4","pages":"Article 100219"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50202020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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