European Journal of Psychiatry最新文献_第7页

Depression and multimorbidity - Results from a nationwide study 抑郁症和多发病——一项全国性研究的结果

IF 1.8 4区医学 Q3 Medicine

European Journal of Psychiatry

Pub Date : 2023-04-01 DOI: 10.1016/j.ejpsy.2022.09.004

Bárbara Pedrosa , Mariana Neto , Sónia Namorado , Andreia Leite

Background and objectives

Most studies concerning the relationship between depression and chronic physical disease focused on a single physical disease and did not consider multimorbidity or depression severity. We aimed to characterize this relationship considering chronic physical diseases’ type and number, and depression severity.

Methods

We undertook a cross-sectional study, using data from a phone household panel, with “chronic physical disease” as the exposure and “depression” as the outcome. The sample is representative of the Portuguese population. Adjusted logistic and multinomial regression analyses were conducted between depression presence/severity and chronic physical disease presence/type/number. Odds ratio and 95% confidence intervals adjusted for possible confounders were calculated.

Results

1027 individuals were included. Of the population, 8.9% had depression and 72.1% had at least one chronic physical disease. There was no statistically significant relationship between depression and physical disease in general (OR=1.68 [CI95%:0.55, 5.15]), but there was with allergy (OR=2.08 [CI95%:1.02, 4.25]) and COPD (OR=3.04 [CI95%:1.21, 7.61]). The risk of depression was smaller with two physical diseases (vs. three or more, OR=0.32 [CI95%:0.15, 0.68]).

Conclusions

A relationship between COPD, allergy and a higher number of physical diseases and depression was observed. Clinicians should be aware of these relationships. Evaluating the presence of depression in people with multimorbidity, COPD and allergy is recommended.

背景与目的关于抑郁症与慢性身体疾病之间关系的大多数研究都集中在单一的身体疾病上，没有考虑多发病或抑郁症的严重程度。考虑到慢性身体疾病的类型和数量以及抑郁症的严重程度，我们旨在描述这种关系。方法我们使用电话家庭小组的数据进行了一项横断面研究，以“慢性身体疾病”为暴露对象，以“抑郁症”为结果。样本代表葡萄牙人口。在抑郁症的存在/严重程度和慢性身体疾病的存在/类型/数量之间进行了调整后的logistic和多项式回归分析。计算可能的混杂因素调整后的比值比和95%置信区间。结果纳入1027人。在人群中，8.9%的人患有抑郁症，72.1%的人至少患有一种慢性身体疾病。抑郁症与一般身体疾病之间没有统计学上的显著关系（OR=1.68[CI95%:0.55，5.15]），但与过敏（OR=2.08[CI95%3.02,4.25]）和慢性阻塞性肺病（OR=3.04[CI95%41.21,7.61]）有关。两种或三种以上的身体疾病患抑郁症的风险较小（与三种以上相比，OR=0.32[CI95%20.15,0.68]），观察到过敏和更高数量的身体疾病和抑郁。临床医生应该意识到这些关系。建议评估多发病、COPD和过敏患者是否存在抑郁症。

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引用次数: 0

The network structure of self-reported psychopathological dimensions in common mental disorders (CMDs) 常见精神障碍（CMDs）自我报告精神病理学维度的网络结构

IF 1.8 4区医学 Q3 Medicine

European Journal of Psychiatry

Pub Date : 2023-04-01 DOI: 10.1016/j.ejpsy.2022.11.003

Manuel J. Cuesta , Juan I. Arrarás , Gustavo J. Gil-Berrozpe , Victor Peralta , Laura Barrado , Olga Correa , Rebeca Elorza , Lorea Fernández , Irma Garmendia , Lucía Janda , Patricia Macaya , Camino Núñez , Pablo Sabater , Aileen Torrejon

Background and objectives

Common mental disorders (CMDs) in mental health settings show high rates of comorbidities. While semi-structured interviews are the gold standard to establish a diagnosis, there are self-report instruments such as the Psychiatric Diagnostic Screening Questionnaire (PDSQ) that aids clinicians in improving the diagnostic process in a time-efficient manner.

Methods

Network analysis of the 13 domains of the PDSQ was applied to a sample of 374 first-contact outpatients to identify domains of psychopathology acting as hubs and bridges of interconnections within the CMDs.

Results

A global network densely connected with positive connections among PDSQ domains was found. The global network has four main clusters: depression-anxiety, somatoform, psychosis and substance-related domains. This network allowed for the identification of main ‘nodes’ acting as hubs favoring interconnections between dimensions and main ‘bridges’ easing the connections between clusters.

Conclusion

The network structure of the PDSQ domains might provide a complementary explanation to the high rates of comorbidity among CMDs. Moreover, our results support the relevance of the self-administered PDSQ inventory to account for a deeper understanding of comorbidities among CMDs.

背景与目的心理健康环境中常见的精神障碍（CMDs）合并症发生率较高。虽然半结构化访谈是确定诊断的金标准，但也有一些自我报告工具，如精神病诊断筛查问卷（PDSQ），可以帮助临床医生及时改进诊断过程。方法对374例首次接触门诊患者进行PDSQ 13个领域的网络分析，以确定精神病理学领域作为CMD内部互连的枢纽和桥梁。全球网络有四个主要集群：抑郁焦虑、体型、精神病和物质相关领域。该网络允许识别作为集线器的主要“节点”，有利于维度之间的互连，并允许识别缓解集群之间连接的主要“桥梁”。结论PDSQ结构域的网络结构可能为CMD合并症的高发病率提供补充解释。此外，我们的研究结果支持自我管理的PDSQ清单的相关性，以解释对CMD合并症的更深入理解。

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引用次数: 1

COVID-19 perceived stigma among survivors: A cross-sectional study of prevalence and predictors 幸存者中新冠肺炎的耻辱感：流行率和预测因素的横断面研究

IF 1.8 4区医学 Q3 Medicine

European Journal of Psychiatry

Pub Date : 2023-01-01 DOI: 10.1016/j.ejpsy.2022.08.004

Mohamad Alchawa , Sarah Naja , Khaled Ali , Vahe Kehyayan , Peter Michael Haddad , Iheb Bougmiza

Background and objectives

Perceived stigma related to infectious diseases is of public health importance and can adversely impact patients' physical and mental health. This study aims to identify the level of perceived stigma among COVID-19 survivors in Qatar and investigate its predictors.

Methods

An analytical cross-sectional design was employed. Four hundred and four participants who had a positive COVID-19 PCR test were randomly selected from medical records. The selected participants were interviewed to collect sociodemographic and health-related information. Perceived stigma was assessed using the COVID-19 perceived stigma scale-22 (CPSS-22) that was developed by the researchers. A descriptive analysis followed by a bivariate analysis investigated possible associations between the perceived stigma levels and independent variables. A multivariable analysis was performed using logistic regression to identify any significant associations with perceived stigma. The validity and reliability of the developed tool were also tested.

Results

The prevalence of COVID-19 perceived stigma was twenty-six percent (n = 107, 26.4%) at 95% CI [22.4–30.4]. Factors associated with higher COVID-19 perceived stigma were male gender, being a manual worker, non-Arabic ethnicity, low educational level, living alone, and being isolated outside the home. However, only occupation, ethnicity, and low educational level predicted COVID-19 perceived stigma in multivariable analysis. The CPSS-22 showed excellent reliability (Cronbach's alpha 0.92).

Conclusion

Perceived stigma was relatively common among participants. Designing programs and interventions targeting male manual workers and those of low-educational levels may assist policymakers in mitigating the stigma related to COVID-19.

背景和目的与传染病相关的感知污名具有公共卫生重要性，会对患者的身心健康产生不利影响。本研究旨在确定卡塔尔新冠肺炎幸存者的耻辱感水平，并调查其预测因素。方法采用横断面分析设计。从医疗记录中随机选择了四十四名新冠肺炎PCR检测呈阳性的参与者。对选定的参与者进行了访谈，以收集社会人口统计和健康相关信息。使用研究人员开发的新冠肺炎感知耻辱量表22（CPSS-22）评估感知耻辱。描述性分析和双变量分析调查了感知污名水平和自变量之间的可能关联。使用逻辑回归进行多变量分析，以确定与感知污名的任何显著关联。还测试了所开发工具的有效性和可靠性。结果新冠肺炎感知耻辱感的患病率为26%（n=107，26.4%），置信区间为95%[22.4-304]。与新冠肺炎感知耻辱感较高相关的因素为男性、体力劳动者、非阿拉伯民族、低教育水平、独自生活和在家外隔离。然而，在多变量分析中，只有职业、种族和低教育水平预测了新冠肺炎的耻辱感。CPSS-22显示出良好的可靠性（Cronbachα0.92）。结论感知耻辱在参与者中相对常见。设计针对男性体力劳动者和低教育水平劳动者的方案和干预措施可能有助于政策制定者减轻与新冠肺炎相关的耻辱。

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引用次数: 4

The relationship between objective and subjective cognitive performance to clinical features in bipolar disorder: A 6 years follow-up study 双相情感障碍患者客观和主观认知表现与临床特征的关系：6年随访研究

IF 1.8 4区医学 Q3 Medicine

European Journal of Psychiatry

Pub Date : 2023-01-01 DOI: 10.1016/j.ejpsy.2022.07.001

Leticia Sanguinetti Czepielewski , Marcia Kauer-Sant'Anna , Flavio Kapczinski , Joana Bücker

引用次数: 0

COMT rs4680 and DRD2 rs6275 variants and their association with YMRS scores in children with early-onset bipolar disorder COMT rs4680和DRD2 rs6275变异及其与早发性双相情感障碍儿童YMRS评分的相关性

IF 1.8 4区医学 Q3 Medicine

European Journal of Psychiatry

Pub Date : 2023-01-01 DOI: 10.1016/j.ejpsy.2022.07.003

M. Cengiz , G. Karacetin , M. Topal , M.E. Yuksel , T. Eseroglu , G.B. Akdeniz , T. Demir , M. Erkiran , A. Dirican , B. Bayoglu

Background and objectives

Bipolar disorder (BD) is a clinical status with at least one manic, hypomanic or mixed attacks. Genetic factors take part significantly in early-onset BD (EOBD). Dopamine receptors (DRD) act in neurological mechanisms like motivation, learning, memory, and, control of neuroendocrine signaling. DRD2 receptor has been reported to influence the stability of DRD2 transcript. Catechol-O-Methyl transferase (COMT) inactivates catecholamines and Val158Met variation on COMT has effects on COMT activity. This study aims to explore DRD2 and COMT variants in the clinical development of EOBD.

Methods

In this case-control study, 102 EOBD patients and 168 healthy control subjects were used. DRD2 rs6275 and COMT Val158Met variations were detected by real-time polymerase chain reaction (RT-PCR). Young Mania Rating Scale (YMRS) was utilized to determine the EOBD severity.

Results

For DRD2 rs6275 and COMT Val158Met polymorphisms, no significant relationship was observed in the genotype and allele frequencies between patient and control groups. Nevertheless, TT genotype carriers of DRD2 rs6275 polymorphism demonstrated significantly increased YMRS scores when compared with CC and CT genotype carriers (p = 0.039). Nevertheless, no significant difference was observed between COMT Val158Met genotypes and YMRS scores.

Conclusions

We suggest that the DRD2 rs6275 TT variant can be associated with symptom severity in children with EOBD and can have a clinical significance in EOBD pathogenesis. However, these results need to be confirmed with larger samples of patient and control groups.

背景与目的躁郁症（BD）是一种临床状态，至少有一次躁狂、轻度躁狂或混合发作。遗传因素在早发性BD（EOBD）中起重要作用。多巴胺受体（DRD）在神经机制中发挥作用，如动机、学习、记忆和神经内分泌信号的控制。DRD2受体已被报道影响DRD2转录物的稳定性。儿茶酚胺-O-甲基转移酶（COMT）使儿茶酚胺失活，而COMT上的Val158Met变异对COMT活性有影响。本研究旨在探讨DRD2和COMT变异在EOBD临床发展中的作用。方法在本病例对照研究中，102名EOBD患者和168名健康对照受试者。实时聚合酶链式反应（RT-PCR）检测DRD2-rs6275和COMT-Val158Met的变异。年轻躁狂评定量表（YMRS）用于确定EOBD的严重程度。结果DRD2 rs6275和COMT Val158Met多态性在患者和对照组之间的基因型和等位基因频率没有显著关系。然而，DRD2 rs6275多态性的TT基因型携带者与CC和CT基因型携带者相比，YMRS评分显著增加（p=0.039）。然而，COMT-Val158Met基因型与YMRS评分之间没有观察到显著差异。结论DRD2 rs6275 TT变异体可能与EOBD患儿的症状严重程度有关，在EOBD的发病机制中具有临床意义。然而，这些结果需要用患者和对照组的更大样本来证实。

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引用次数: 0

Obsessive-compulsive symptoms associated with left temporal dysembryoplastic neuroepithelial tumor: A case report 左侧颞叶胚胎发育不良神经上皮肿瘤伴强迫症1例

IF 1.8 4区医学 Q3 Medicine

European Journal of Psychiatry

Pub Date : 2023-01-01 DOI: 10.1016/j.ejpsy.2022.09.001

Ritwik Ghosh , Abhiram Narasimhan Purohith , G. Lakshmi Prasad , Rashmi Appaji , Sonia Shenoy

引用次数: 0

Serum brain-derived neurotrophic factor levels in depression with and without melancholy and in healthy participants 抑郁症伴忧郁和不伴忧郁及健康参与者血清脑源性神经营养因子水平

IF 1.8 4区医学 Q3 Medicine

European Journal of Psychiatry

Pub Date : 2023-01-01 DOI: 10.1016/j.ejpsy.2022.08.002

Reiji Yoshimura, Naomichi Okamoto, Atsuko Ikenouchi

引用次数: 0

Relationship between the expression level of miRNA-4485 and the severity of depressive symptoms in major depressive disorder patients miRNA-4485表达水平与重度抑郁症患者抑郁症状严重程度的关系

IF 1.8 4区医学 Q3 Medicine

European Journal of Psychiatry

Pub Date : 2023-01-01 DOI: 10.1016/j.ejpsy.2022.09.005

Hong-tao Song , Xin-yang Sun , Wei Niu , Qiao-li Zhang , Li-yi Zhang , Ai-fang Zhong

Background and objectives

Despite the growing pieces of evidence on the relationship between the altered expression level of miRNAs and major depressive disorder (MDD), few studies have focused on the relationship between the altered expression of miRNAs and the severity of depressive symptoms. This study aimed to investigate the relationship between the expression level of miRNA-4485 and the severity of depressive symptoms in major depressive disorder (MDD) patients.

Methods

Eighty MDD patients without antidepressants and 45 healthy controls were placed and tested for the expression level of miRNA-4485 using quantitative RT‒PCR. At the same time, the Hamilton Depression Scale (HAMD) was used to assess depression symptoms for MDD patients. Twenty-nine out of 80 MDD patients were selected for miRNA expression level testing and symptomatology assessments before and after three weeks of treatment.

Results

The expression level of miRNA-4485 in the MDD group was significantly overexpressed compared to that in healthy controls (P < 0.05), and the expression level of miRNA-4485 in the higher HAMD group was also much higher than that in the lower HAMD group and healthy controls (P < 0.05). The expression level of miRNA-4485 in MDD patients was negatively correlated with HAMD total score, anxiety/somatization, and bodyweight factor score (P < 0.05), accounting for 9.4%, 12.4% and 5.7%, respectively. MiRNA-4485 significantly predicted MDD and the severity of depressive symptoms (P < 0.05). Compared with that before treatment, the expression level of miRNA-4485 was significantly downregulated after treatment, while the patient's depressive symptoms were improved (p < 0.05). The improvement in depressive symptoms was positively correlated with the downregulation of miRNA-4485, which could significantly predict the effects of antidepressant treatment on MDD (P < 0.05).

Conclusion

MiRNA-4485, which is significantly related to depressive symptoms and its improvement, could be a valuable biomarker or drug target to predict MDD, the severity of depressive symptoms and the effects of antidepressant treatment on MDD.

背景和目的尽管越来越多的证据表明miRNA表达水平的改变与重度抑郁症（MDD）之间的关系，但很少有研究关注miRNA表达的改变与抑郁症症状严重程度之间的关系。本研究旨在探讨严重抑郁障碍（MDD）患者中miRNA-4485的表达水平与抑郁症状严重程度之间的关系。方法对80例未服用抗抑郁药的MDD患者和45名健康对照进行定量RT-PCR检测miRNA-4485的表达水平。同时，汉密尔顿抑郁量表（HAMD）用于评估MDD患者的抑郁症状。从80名MDD患者中选择29名在治疗前和治疗三周后进行miRNA表达水平测试和症状评估。结果MDD组miRNA-4485的表达水平显著高于健康对照组（P＜0.05），高HAMD组的miRNA-4485表达水平也远高于低HAMD组和健康对照组（P<；0.05）。MDD患者的miRNA44485表达水平与HAMD总分、焦虑/躯体化和体重因子评分呈负相关（P<），分别占9.4%、12.4%和5.7%。MiRNA-4485可显著预测MDD和抑郁症状的严重程度（P<；0.05）。与治疗前相比，MiRNA-4485%的表达水平在治疗后显著下调，而患者的抑郁症状有所改善（P<）。抑郁症状的改善与MiRNA-44八十五的下调呈正相关，结论miRNA-4485与抑郁症状及其改善显著相关，可作为预测MDD、抑郁症状严重程度和抗抑郁治疗对MDD影响的有价值的生物标志物或药物靶点。

{"title":"Relationship between the expression level of miRNA-4485 and the severity of depressive symptoms in major depressive disorder patients","authors":"Hong-tao Song , Xin-yang Sun , Wei Niu , Qiao-li Zhang , Li-yi Zhang , Ai-fang Zhong","doi":"10.1016/j.ejpsy.2022.09.005","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2022.09.005","url":null,"abstract":"<div><h3>Background and objectives</h3><p><span>Despite the growing pieces of evidence on the relationship between the altered expression level of miRNAs and </span>major depressive disorder (MDD), few studies have focused on the relationship between the altered expression of miRNAs and the severity of depressive symptoms. This study aimed to investigate the relationship between the expression level of miRNA-4485 and the severity of depressive symptoms in major depressive disorder (MDD) patients.</p></div><div><h3>Methods</h3><p>Eighty MDD patients without antidepressants and 45 healthy controls were placed and tested for the expression level of miRNA-4485 using quantitative RT‒PCR. At the same time, the Hamilton Depression Scale<span> (HAMD) was used to assess depression symptoms for MDD patients. Twenty-nine out of 80 MDD patients were selected for miRNA expression level testing and symptomatology<span> assessments before and after three weeks of treatment.</span></span></p></div><div><h3>Results</h3><p>The expression level of miRNA-4485 in the MDD group was significantly overexpressed compared to that in healthy controls (<em>P <</em> 0.05), and the expression level of miRNA-4485 in the higher HAMD group was also much higher than that in the lower HAMD group and healthy controls (<em>P <</em> 0.05). The expression level of miRNA-4485 in MDD patients was negatively correlated with HAMD total score, anxiety/somatization, and bodyweight factor score (<em>P <</em> 0.05), accounting for 9.4%, 12.4% and 5.7%, respectively. MiRNA-4485 significantly predicted MDD and the severity of depressive symptoms (<em>P <</em> 0.05). Compared with that before treatment, the expression level of miRNA-4485 was significantly downregulated after treatment, while the patient's depressive symptoms were improved (<em>p <</em> 0.05). The improvement in depressive symptoms was positively correlated with the downregulation of miRNA-4485, which could significantly predict the effects of antidepressant treatment on MDD (<em>P <</em> 0.05).</p></div><div><h3>Conclusion</h3><p>MiRNA-4485, which is significantly related to depressive symptoms and its improvement, could be a valuable biomarker or drug target to predict MDD, the severity of depressive symptoms and the effects of antidepressant treatment on MDD.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antipsychotic drug prescription sequence analysis in relation to death occurrence and cardiometabolic drug usage: A retrospective longitudinal study 抗精神病药物处方序列分析与死亡发生和心脏代谢药物使用的关系：一项回顾性纵向研究

IF 1.8 4区医学 Q3 Medicine

European Journal of Psychiatry

Pub Date : 2023-01-01 DOI: 10.1016/j.ejpsy.2022.06.002

Paweł Zagozdzon , Piotr Dorozynski , Przemysław Waszak , Adam Harasimowicz , Tomasz Dziubich

Background and objectives

The potential role of antipsychotics in increasing cardiovascular risk of mortality is still debated. The aim of this study was to assess the death risk associated with sequences of first-generation antipsychotic (FGA) and second-generation antipsychotic (SGA) prescriptions, including clozapine and lithium, and drugs for cardiometabolic diseases.

Methods

We conducted a retrospective longitudinal analysis involving 84,881 patients who received antipsychotics between 2008 and 2012. Data on deaths were collected from the National Death Registry. The sequence creation was performed according to an algorithm that iterates prescriptions in chronological order and appends them to the end of the patient's prescription sequence. Fuzzy set qualitative comparative analysis (FsQCA) was also used to produce causal combinations of conditions that best lead to survival.

Results

There were 1,095,518 antipsychotic prescriptions and 16,010 deaths among antipsychotic users. Among the reimbursement data, 85,272 drug sequences were identified. The most prevalent sequence consisted of FGA (69.1%). Subsequent groups consisted of FGA, followed by SGA (13.1%) and SGA-only (12.3%) sequences. The highest occurrence of death and cardiometabolic drug use after introducing antipsychotic treatment was observed for clozapine. The FsQCA analysis revealed the highest coverage for combinations of young age with FGA (40.6%) or with no cardiometabolic risk factors drug therapy (39.5%).

Conclusion

The sequence analysis suggests that clozapine is associated with an increased death risk compared to FGA and SGA.

背景和目的抗精神病药物在增加心血管死亡风险中的潜在作用仍存在争议。本研究的目的是评估与第一代抗精神病药物（FGA）和第二代抗精神疾病药物（SGA）处方序列相关的死亡风险，包括氯氮平和锂，以及治疗心脏代谢疾病的药物。方法我们对2008年至2012年间接受抗精神病药物治疗的84881名患者进行了回顾性纵向分析。死亡数据是从国家死亡登记处收集的。序列创建是根据一种算法执行的，该算法按时间顺序迭代处方，并将其附加到患者处方序列的末尾。模糊集定性比较分析（FsQCA）也被用于产生最能导致存活的条件的因果组合。结果抗精神病药物使用者共开出1095518张抗精神病药处方，16010人死亡。在报销数据中，确定了85272个药物序列。最常见的序列是FGA（69.1%）。随后的组由FGA组成，其次是SGA（13.1%）和仅SGA（12.3%）序列。氯氮平在引入抗精神病药物治疗后死亡和心脏代谢药物使用的发生率最高。FsQCA分析显示，年轻时有FGA（40.6%）或没有心脏代谢危险因素药物治疗（39.5%）的组合覆盖率最高。结论序列分析表明，与FGA和SGA相比，氯氮平与死亡风险增加有关。

{"title":"Antipsychotic drug prescription sequence analysis in relation to death occurrence and cardiometabolic drug usage: A retrospective longitudinal study","authors":"Paweł Zagozdzon , Piotr Dorozynski , Przemysław Waszak , Adam Harasimowicz , Tomasz Dziubich","doi":"10.1016/j.ejpsy.2022.06.002","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2022.06.002","url":null,"abstract":"<div><h3>Background and objectives</h3><p>The potential role of antipsychotics<span> in increasing cardiovascular risk of mortality is still debated. The aim of this study was to assess the death risk associated with sequences of first-generation antipsychotic (FGA) and second-generation antipsychotic (SGA) prescriptions, including clozapine<span> and lithium, and drugs<span> for cardiometabolic diseases.</span></span></span></p></div><div><h3>Methods</h3><p>We conducted a retrospective longitudinal analysis involving 84,881 patients who received antipsychotics between 2008 and 2012. Data on deaths were collected from the National Death Registry. The sequence creation was performed according to an algorithm that iterates prescriptions in chronological order and appends them to the end of the patient's prescription sequence. Fuzzy set qualitative comparative analysis (FsQCA) was also used to produce causal combinations of conditions that best lead to survival.</p></div><div><h3>Results</h3><p>There were 1,095,518 antipsychotic prescriptions and 16,010 deaths among antipsychotic users. Among the reimbursement data, 85,272 drug sequences were identified. The most prevalent sequence consisted of FGA (69.1%). Subsequent groups consisted of FGA, followed by SGA (13.1%) and SGA-only (12.3%) sequences. The highest occurrence of death and cardiometabolic drug use after introducing antipsychotic treatment was observed for clozapine. The FsQCA analysis revealed the highest coverage for combinations of young age with FGA (40.6%) or with no cardiometabolic risk factors drug therapy (39.5%).</p></div><div><h3>Conclusion</h3><p>The sequence analysis suggests that clozapine is associated with an increased death risk compared to FGA and SGA.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Patients’ perspectives on telemedicine in the encounter between healthcare and patients with mental illness: A systematic review 在医疗保健和精神疾病患者之间的接触中，患者对远程医疗的看法：一项系统综述

IF 1.8 4区医学 Q3 Medicine

European Journal of Psychiatry

Pub Date : 2023-01-01 DOI: 10.1016/j.ejpsy.2022.08.003

Sally Wulff Jørgensen , Kim Lee , Søren Harnow Klausen , Esben Nedenskov Petersen , Birgitte Nørgaard

Background and objectives

This systematic review aimed to investigate the experiences and opinions of people with mental illness regarding the role of telemedicine in their treatment.

Methods

To be eligible, studies were required to include people between 18 and 65 years of age with mental illness, defined as depression, anxiety, bipolar disorder, schizophrenia, or personality disorder. It was further required that the patients’ experiences of the telehealth solutions were reported. Between April 5, 2020, and June 29, 2020 (renewed November 10, 2021), the CINAHL electronic database was searched. Using the OVID search engine, Embase, MEDLINE, and PsycINFO were likewise searched; gray literature was retrieved from Scopus. The included studies were critically appraised using the CASP checklists.

Results

Seventeen studies were included. Treatment provided via telehealth technology offered people with mental illness insights and skills that helped them cope better in everyday life. The patient—therapist relationship was improved where the parties collaborated. Furthermore, gaining control of one's mental health by using an app and following one's development empowered people with mental illness, leading to greater involvement in treatment.

Conclusions

Engaging people with mental illness in decisions concerning the use of telehealth technology is essential. It is likewise important that both people with mental illness and health professionals have access to help with the implementation of technology, and that telehealth solutions function as a supplement rather than a substitute for face-to-face treatment.

背景和目的本系统综述旨在调查精神疾病患者对远程医疗在其治疗中的作用的经验和意见。方法为了获得资格，研究需要包括18至65岁的精神疾病患者，定义为抑郁症、焦虑症、双相情感障碍、精神分裂症或人格障碍。还要求报告患者对远程医疗解决方案的体验。在2020年4月5日至2020年6月29日（2021年11月10日更新）期间，搜索了CINAHL电子数据库。使用OVID搜索引擎，同样搜索Embase、MEDLINE和PsycINFO；灰色文献检索自Scopus。纳入的研究使用CASP检查表进行了批判性评估。结果纳入17项研究。通过远程医疗技术提供的治疗为人们提供了心理疾病的见解和技能，帮助他们更好地应对日常生活。双方合作改善了患者与治疗师的关系。此外，通过使用应用程序和跟踪自己的发展来控制自己的心理健康，可以增强精神疾病患者的能力，从而使他们更多地参与治疗。结论让精神疾病患者参与远程医疗技术的使用决策至关重要。同样重要的是，精神病患者和卫生专业人员都能获得技术实施方面的帮助，远程医疗解决方案是面对面治疗的补充而不是替代。

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引用次数: 2