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European journal of preventive cardiology最新文献

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The Mysterious Lipoprotein(a): Moving Towards Further Understanding of its Atherogenic Role. 神秘的脂蛋白(a):进一步了解脂蛋白(a)的致动脉粥样硬化作用。
IF 8.4 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-17 DOI: 10.1093/eurjpc/zwae321
Viviane Z Rocha, Raul D Santos
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引用次数: 0
Genetic Correlations and Causal Insights: Pathways to Precision Medicine in Patients with Obstructive Sleep Apnea and Cardiovascular Disease. 遗传相关性与因果关系:阻塞性睡眠呼吸暂停和心血管疾病患者的精准医疗之路。
IF 8.4 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-17 DOI: 10.1093/eurjpc/zwae343
Yang Chen, Hong Yu Liu, Gregory Y H Lip
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引用次数: 0
High nicotine dependence - does knowing your genetic susceptibility for atrial fibrillation help to quit smoking? 尼古丁高度依赖--了解心房颤动的遗传易感性有助于戒烟吗?
IF 8.4 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-15 DOI: 10.1093/eurjpc/zwae328
Maja-Lisa Løchen, Victor Aboyans
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引用次数: 0
The Association between Non-Alcohol Liver Fatty Disease and Coronary Artery Calcification: A Two-Sample Mendelian Randomization Study. 非酒精性肝脂肪疾病与冠状动脉钙化之间的关系:双样本孟德尔随机研究
IF 8.4 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-14 DOI: 10.1093/eurjpc/zwae336
Liaoming He, Xieraili Tiemuerniyazi, Ziang Yang, Shengkang Huang, Lianxin Chen, Yifeng Nan, Yangwu Song, Wei Feng

Background: Although prior observational studies have suggested that patients with non-alcohol fatty liver disease (NAFLD) may have a higher risk of coronary artery calcification (CAC), these findings remain controversial. This study aimed to explore the causal association between NAFLD and CAC at genetic level by two-sample Mendelian randomization (MR) analysis.

Method: Utilizing summary-level data from multiple large-scale genome-wide association studies (GWAS) in European populations, a two-sample MR analysis was initially conducted to explore the potential causal association between NAFLD and CAC. The results of the MR analysis were pooled through random-effect meta-analysis. The inverse variance weighting (IVW) method served as the primary approach for MR analysis. Additionally, the weighted median, MR-Egger and MR-pleiotropy residual sum and outlier (MR-PRESSO) methods was applied for sensitivity analysis. Summary-level data on liver fatty content was utilized for validation analysis, while summary-level data on cirrhosis served as positive control, further ensuring the validity and robustness of our findings. Reverse MR analysis was performed to assess the association between CAC and NAFLD, employing instrument variables derived from CAC.

Results: The MR analysis indicated that genetically predicted NAFLD had no effects on the risk of CAC (Beta: 0.01, 95% CI: -0.02 to 0.03, P = 0.74). Likewise, the reverse MR analysis found no significant genetic association between CAC and NAFLD (OR: 1.00, 95% CI: 0.96 to 1.06, P = 0.88). Validation analysis yielded consistent results, showing no significant association between fatty liver content and CAC.

Conclusion: Our two-sample MR analysis did not support that there is a causal association between NAFLD and CAC at genetic level. The association between NAFLD and CAC reported in some previous observational studies may rely on NAFLD complicated with metabolic disorders, rather than being directly linked to the hepatic steatosis.

背景:尽管之前的观察性研究表明,非酒精性脂肪肝(NAFLD)患者可能具有较高的冠状动脉钙化(CAC)风险,但这些研究结果仍存在争议。本研究旨在通过双样本孟德尔随机化(MR)分析探讨非酒精性脂肪肝与冠状动脉钙化之间在基因水平上的因果关系:利用欧洲人群中多个大规模全基因组关联研究(GWAS)的汇总数据,首先进行了双样本 MR 分析,以探讨非酒精性脂肪肝与 CAC 之间的潜在因果关系。MR 分析的结果通过随机效应荟萃分析进行了汇总。反方差加权(IVW)法是MR分析的主要方法。此外,加权中值法、MR-Egger 法和 MR-pleiotropy 残差和离群值法(MR-PRESSO)也被用于敏感性分析。肝脏脂肪含量的汇总数据用于验证分析,肝硬化的汇总数据作为阳性对照,进一步确保了我们研究结果的有效性和稳健性。我们利用从 CAC 衍生出的工具变量进行了反向 MR 分析,以评估 CAC 与非酒精性脂肪肝之间的关联:MR分析表明,遗传预测的非酒精性脂肪肝对CAC风险没有影响(Beta:0.01,95% CI:-0.02 至 0.03,P = 0.74)。同样,反向 MR 分析也发现 CAC 与非酒精性脂肪肝之间没有明显的遗传关联(OR:1.00,95% CI:0.96 至 1.06,P = 0.88)。验证分析结果一致,显示脂肪肝含量与CAC之间没有明显关联:我们的双样本 MR 分析并不支持非酒精性脂肪肝与 CAC 之间在基因水平上存在因果关系。以往一些观察性研究中报道的非酒精性脂肪肝与 CAC 之间的关联可能依赖于非酒精性脂肪肝并发代谢紊乱,而非与肝脏脂肪变性直接相关。
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引用次数: 0
Risk factors for cardiovascular disease: the known unknown. 心血管疾病的风险因素:已知的未知数。
IF 8.4 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-10 DOI: 10.1093/eurjpc/zwad392
Vicente Artola Arita, Sara Beigrezaei, Oscar H Franco
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引用次数: 0
Being a cardiologist looking in the mirror of prognosis assessment: who am I, a wizard or a mathematician? 作为一名心脏病学家,从预后评估这面镜子中看自己:我是谁,魔法师还是数学家?
IF 8.4 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-10 DOI: 10.1093/eurjpc/zwae127
Piergiuseppe Agostoni, Massimo Mapelli, Alice Bonomi, Elisabetta Salvioni
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引用次数: 0
High blood pressure and intracerebral haemorrhage: a recognized risk factor with new knowledge. 高血压与脑出血。一个公认的风险因素与新知识。
IF 8.4 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-10 DOI: 10.1093/eurjpc/zwae187
Sergio Cinza-Sanjurjo, José R González-Juanatey
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引用次数: 0
A new editorial board for the European Journal of Preventive Cardiology: moving to a more global podium for cardiovascular research in preventive cardiology. 欧洲预防心脏病学杂志》的新编辑委员会:为预防心脏病学领域的心血管研究搭建一个更具全球性的平台。
IF 8.4 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-10 DOI: 10.1093/eurjpc/zwae243
Victor Aboyans
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引用次数: 0
Correction to: Prevention and rehabilitation after heart transplantation: A clinical consensus statement of the European Association of Preventive Cardiology, Heart Failure Association of the ESC, and the European Cardio Thoracic Transplant Association, a section of ESOT. 更正为心脏移植术后的预防和康复:欧洲预防心脏病学协会、ESC 心力衰竭协会和 ESOT 分支机构欧洲心胸移植协会的临床共识声明。
IF 8.4 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-10 DOI: 10.1093/eurjpc/zwae226
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引用次数: 0
Prediction of individual lifetime cardiovascular risk and potential treatment benefit: development and recalibration of the LIFE-CVD2 model to four European risk regions. 预测个人终生心血管风险和潜在治疗获益:开发并重新校准适用于四个欧洲风险地区的 LIFE-CVD2 模型。
IF 8.4 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-10 DOI: 10.1093/eurjpc/zwae174
Steven H J Hageman, Stephen Kaptoge, Tamar I de Vries, Wentian Lu, Janet M Kist, Hendrikus J A van Os, Mattijs E Numans, Kristi Läll, Martin Bobak, Hynek Pikhart, Ruzena Kubinova, Sofia Malyutina, Andrzej Pająk, Abdonas Tamosiunas, Raimund Erbel, Andreas Stang, Börge Schmidt, Sara Schramm, Thomas R Bolton, Sarah Spackman, Stephan J L Bakker, Michael Blaha, Jolanda M A Boer, Amélie Bonnefond, Hermann Brenner, Eric J Brunner, Nancy R Cook, Karina Davidson, Elaine Dennison, Chiara Donfrancesco, Marcus Dörr, James S Floyd, Ian Ford, Michael Fu, Ron T Gansevoort, Simona Giampaoli, Richard F Gillum, Agustín Gómez-de-la-Cámara, Lise Lund Håheim, Per-Olof Hansson, Peter Harms, Steve E Humphries, M Kamran Ikram, J Wouter Jukema, Maryam Kavousi, Stefan Kiechl, Anna Kucharska-Newton, David Lora Pablos, Kunihiro Matsushita, Haakon E Meyer, Karel G M Moons, Martin Bødtker Mortensen, Mirthe Muilwijk, Børge G Nordestgaard, Chris Packard, Luigi Pamieri, Demosthenes Panagiotakos, Annette Peters, Louis Potier, Rui Providencia, Bruce M Psaty, Paul M Ridker, Beatriz Rodriguez, Annika Rosengren, Naveed Sattar, Ben Schöttker, Joseph E Schwartz, Steven Shea, Martin J Shipley, Reecha Sofat, Barbara Thorand, W M Monique Verschuren, Henry Völzke, Nicholas J Wareham, Leo Westbury, Peter Willeit, Bin Zhou, John Danesh, Frank L J Visseren, Emanuele Di Angelantonio, Lisa Pennells, Jannick A N Dorresteijn

Aims: The 2021 European Society of Cardiology prevention guidelines recommend the use of (lifetime) risk prediction models to aid decisions regarding initiation of prevention. We aimed to update and systematically recalibrate the LIFEtime-perspective CardioVascular Disease (LIFE-CVD) model to four European risk regions for the estimation of lifetime CVD risk for apparently healthy individuals.

Methods and results: The updated LIFE-CVD (i.e. LIFE-CVD2) models were derived using individual participant data from 44 cohorts in 13 countries (687 135 individuals without established CVD, 30 939 CVD events in median 10.7 years of follow-up). LIFE-CVD2 uses sex-specific functions to estimate the lifetime risk of fatal and non-fatal CVD events with adjustment for the competing risk of non-CVD death and is systematically recalibrated to four distinct European risk regions. The updated models showed good discrimination in external validation among 1 657 707 individuals (61 311 CVD events) from eight additional European cohorts in seven countries, with a pooled C-index of 0.795 (95% confidence interval 0.767-0.822). Predicted and observed CVD event risks were well calibrated in population-wide electronic health records data in the UK (Clinical Practice Research Datalink) and the Netherlands (Extramural LUMC Academic Network). When using LIFE-CVD2 to estimate potential gain in CVD-free life expectancy from preventive therapy, projections varied by risk region reflecting important regional differences in absolute lifetime risk. For example, a 50-year-old smoking woman with a systolic blood pressure (SBP) of 140 mmHg was estimated to gain 0.9 years in the low-risk region vs. 1.6 years in the very high-risk region from lifelong 10 mmHg SBP reduction. The benefit of smoking cessation for this individual ranged from 3.6 years in the low-risk region to 4.8 years in the very high-risk region.

Conclusion: By taking into account geographical differences in CVD incidence using contemporary representative data sources, the recalibrated LIFE-CVD2 model provides a more accurate tool for the prediction of lifetime risk and CVD-free life expectancy for individuals without previous CVD, facilitating shared decision-making for cardiovascular prevention as recommended by 2021 European guidelines.

目的:2021 年欧洲心脏病学会预防指南建议使用(终生)风险预测模型来帮助做出开始预防的决定。我们旨在更新并系统性地重新校准 LIFE-CVD(LIFE-time-perspective CardioVascular Disease)模型,使其适用于四个欧洲风险地区,以估算表面健康的个体终生心血管疾病风险:更新后的 LIFE-CVD(即 LIFE-CVD2)模型是利用 13 个国家 44 个队列中的个人参与者数据得出的(687135 人未确诊心血管疾病,在中位 10.7 年的随访中发生了 30939 起心血管疾病事件)。LIFE-CVD2 使用性别特异性函数来估算致命和非致命心血管疾病事件的终生风险,并对非心血管疾病死亡的竞争风险进行调整,还根据四个不同的欧洲风险地区进行了系统的重新校准。更新后的模型在来自七个国家的八个额外欧洲队列的 1,657,707 人(61,311 起心血管疾病事件)的外部验证中显示出良好的区分度,汇总 C 指数为 0.795(95%CI 0.767-0.822)。在英国(CPRD)和荷兰(ELAN)的全人口电子健康记录数据中,预测和观察到的心血管疾病事件风险得到了很好的校准。在使用 LIFE-CVD2 估算预防性治疗对无心血管疾病预期寿命的潜在增益时,不同风险地区的预测结果各不相同,这反映出各地区在终生绝对风险方面存在重大差异。例如,一名 50 岁吸烟妇女的 SBP 为 140 毫米汞柱,据估计,如果终生降低 10 毫米汞柱的 SBP,在低风险地区可获得 0.9 年的预期寿命,而在极高风险地区则可获得 1.6 年的预期寿命。该患者的戒烟收益从低风险地区的 3.6 年到极高风险地区的 4.8 年不等:通过使用当代具有代表性的数据源考虑心血管疾病发病率的地域差异,重新校准后的 LIFE-CVD2 模型为预测既往无心血管疾病的个体的终生风险和无心血管疾病的预期寿命提供了更准确的工具,有助于根据 2021 年欧洲指南的建议共同做出心血管疾病预防决策。
{"title":"Prediction of individual lifetime cardiovascular risk and potential treatment benefit: development and recalibration of the LIFE-CVD2 model to four European risk regions.","authors":"Steven H J Hageman, Stephen Kaptoge, Tamar I de Vries, Wentian Lu, Janet M Kist, Hendrikus J A van Os, Mattijs E Numans, Kristi Läll, Martin Bobak, Hynek Pikhart, Ruzena Kubinova, Sofia Malyutina, Andrzej Pająk, Abdonas Tamosiunas, Raimund Erbel, Andreas Stang, Börge Schmidt, Sara Schramm, Thomas R Bolton, Sarah Spackman, Stephan J L Bakker, Michael Blaha, Jolanda M A Boer, Amélie Bonnefond, Hermann Brenner, Eric J Brunner, Nancy R Cook, Karina Davidson, Elaine Dennison, Chiara Donfrancesco, Marcus Dörr, James S Floyd, Ian Ford, Michael Fu, Ron T Gansevoort, Simona Giampaoli, Richard F Gillum, Agustín Gómez-de-la-Cámara, Lise Lund Håheim, Per-Olof Hansson, Peter Harms, Steve E Humphries, M Kamran Ikram, J Wouter Jukema, Maryam Kavousi, Stefan Kiechl, Anna Kucharska-Newton, David Lora Pablos, Kunihiro Matsushita, Haakon E Meyer, Karel G M Moons, Martin Bødtker Mortensen, Mirthe Muilwijk, Børge G Nordestgaard, Chris Packard, Luigi Pamieri, Demosthenes Panagiotakos, Annette Peters, Louis Potier, Rui Providencia, Bruce M Psaty, Paul M Ridker, Beatriz Rodriguez, Annika Rosengren, Naveed Sattar, Ben Schöttker, Joseph E Schwartz, Steven Shea, Martin J Shipley, Reecha Sofat, Barbara Thorand, W M Monique Verschuren, Henry Völzke, Nicholas J Wareham, Leo Westbury, Peter Willeit, Bin Zhou, John Danesh, Frank L J Visseren, Emanuele Di Angelantonio, Lisa Pennells, Jannick A N Dorresteijn","doi":"10.1093/eurjpc/zwae174","DOIUrl":"10.1093/eurjpc/zwae174","url":null,"abstract":"<p><strong>Aims: </strong>The 2021 European Society of Cardiology prevention guidelines recommend the use of (lifetime) risk prediction models to aid decisions regarding initiation of prevention. We aimed to update and systematically recalibrate the LIFEtime-perspective CardioVascular Disease (LIFE-CVD) model to four European risk regions for the estimation of lifetime CVD risk for apparently healthy individuals.</p><p><strong>Methods and results: </strong>The updated LIFE-CVD (i.e. LIFE-CVD2) models were derived using individual participant data from 44 cohorts in 13 countries (687 135 individuals without established CVD, 30 939 CVD events in median 10.7 years of follow-up). LIFE-CVD2 uses sex-specific functions to estimate the lifetime risk of fatal and non-fatal CVD events with adjustment for the competing risk of non-CVD death and is systematically recalibrated to four distinct European risk regions. The updated models showed good discrimination in external validation among 1 657 707 individuals (61 311 CVD events) from eight additional European cohorts in seven countries, with a pooled C-index of 0.795 (95% confidence interval 0.767-0.822). Predicted and observed CVD event risks were well calibrated in population-wide electronic health records data in the UK (Clinical Practice Research Datalink) and the Netherlands (Extramural LUMC Academic Network). When using LIFE-CVD2 to estimate potential gain in CVD-free life expectancy from preventive therapy, projections varied by risk region reflecting important regional differences in absolute lifetime risk. For example, a 50-year-old smoking woman with a systolic blood pressure (SBP) of 140 mmHg was estimated to gain 0.9 years in the low-risk region vs. 1.6 years in the very high-risk region from lifelong 10 mmHg SBP reduction. The benefit of smoking cessation for this individual ranged from 3.6 years in the low-risk region to 4.8 years in the very high-risk region.</p><p><strong>Conclusion: </strong>By taking into account geographical differences in CVD incidence using contemporary representative data sources, the recalibrated LIFE-CVD2 model provides a more accurate tool for the prediction of lifetime risk and CVD-free life expectancy for individuals without previous CVD, facilitating shared decision-making for cardiovascular prevention as recommended by 2021 European guidelines.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":null,"pages":null},"PeriodicalIF":8.4,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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European journal of preventive cardiology
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