Anna Kurasz, Gregory Y H Lip, Michał Święczkowski, Anna Tomaszuk-Kazberuk, Sławomir Dobrzycki, Łukasz Kuźma
Aim: Air pollution remains the single largest environmental health risk factor, while atrial fibrillation (AF) is the most prevalent arrhythmia globally. The study aimed to investigate the relationship between short-term exposure to air pollution and acute AF admissions.
Methods: Individual data on AF hospitalization in the years 2011-2020 were collected from the National Health Fund in Poland (ICD-10: I48.XX). To obtain high-resolution data on air pollution we applied a modelling method using the GEM-AQ model. Associations between air pollution exposure and acute AF admissions were estimated using generalized additive models with Poisson regression.
Results: Over the analysed period, we recorded 252,566 acute admissions due to AF. Each 10 µg/m3 increment of PM2.5 and NO2 concentration, 1 µg/m3 of SO2 and 10 ng/m3 of benzo(a)pyrene (BaP) concentration on the day of exposure resulted in 1.13% (0.70%-1.55%), 1.65% (1.05%-2.26%), 0.11% (0.01%-0.21%), and 0.3% (0.04%-0.55%) increases in acute AF admissions, respectively. The estimates are larger for women and older people. Stronger associations between PM2.5 and BaP concentrations and AF admissions in poorly urbanized areas were noted. Areas with high gross domestic product levels were more affected by the increase in NO2 concentrations, resulting in a 0.2% (1.001-1.003) increase in AF admissions. Exposure-response functions show steeper slopes of the pollutant-outcome associations in the lower ranges of exposures, far below World Health Organization (WHO) air quality guideline norms. For the zero-emission scenario, we estimate avoidable AF admissions - 5,873 for PM2.5 (95% CI 3,679 to 8,047) and 3,295 for NO2 (2,108-4,477).
Conclusions: Air pollution acts as a triggering factor and can be associated with acute AF hospitalisations. PM2.5 and NO2 have an impact on AF even at concentrations levels below WHO air quality guideline norms.
目的：空气污染仍然是最大的环境健康风险因素，而心房颤动（AF）是全球最常见的心律失常。该研究旨在调查短期暴露于空气污染与急性房颤入院之间的关系。方法：2011-2020年AF住院的个人数据收集自波兰国家卫生基金（ICD-10: I48.XX）。为了获得高分辨率的空气污染数据，我们采用了GEM-AQ模型的建模方法。使用泊松回归的广义加性模型估计空气污染暴露与急性房间隔入院之间的关系。结果：在分析期间，我们记录了252566例AF急性入院病例。暴露当天PM2.5和NO2浓度每增加10µg/m3， SO2浓度每增加1µg/m3，苯并(a)芘（BaP）浓度每增加10 ng/m3，分别导致急性AF入院病例增加1.13%(0.70%-1.55%),1.65%(1.05%-2.26%),0.11%（0.01%-0.21%）和0.3%（0.04%-0.55%）。对女性和老年人的估计更大。在城市化程度较低的地区，PM2.5和BaP浓度与房颤入院之间存在更强的关联。国内生产总值水平高的地区受NO2浓度增加的影响更大，导致AF入院人数增加0.2%（1.001-1.003）。暴露-反应函数显示，在远低于世界卫生组织（世卫组织）空气质量准则标准的较低暴露范围内，污染物后果关联的斜率更陡。对于零排放情景，我们估计可避免的AF入院人数- PM2.5为5,873人（95% CI 3,679至8,047），二氧化氮为3,295人（2,108-4,477）。结论：空气污染是诱发因素，与急性房颤住院有关。即使PM2.5和二氧化氮的浓度低于世卫组织空气质量指南标准，也会对AF产生影响。
{"title":"Air quality and the risk of acute atrial fibrillation (EP-PARTICLES study): A nationwide study in Poland.","authors":"Anna Kurasz, Gregory Y H Lip, Michał Święczkowski, Anna Tomaszuk-Kazberuk, Sławomir Dobrzycki, Łukasz Kuźma","doi":"10.1093/eurjpc/zwaf016","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf016","url":null,"abstract":"<p><strong>Aim: </strong>Air pollution remains the single largest environmental health risk factor, while atrial fibrillation (AF) is the most prevalent arrhythmia globally. The study aimed to investigate the relationship between short-term exposure to air pollution and acute AF admissions.</p><p><strong>Methods: </strong>Individual data on AF hospitalization in the years 2011-2020 were collected from the National Health Fund in Poland (ICD-10: I48.XX). To obtain high-resolution data on air pollution we applied a modelling method using the GEM-AQ model. Associations between air pollution exposure and acute AF admissions were estimated using generalized additive models with Poisson regression.</p><p><strong>Results: </strong>Over the analysed period, we recorded 252,566 acute admissions due to AF. Each 10 µg/m3 increment of PM2.5 and NO2 concentration, 1 µg/m3 of SO2 and 10 ng/m3 of benzo(a)pyrene (BaP) concentration on the day of exposure resulted in 1.13% (0.70%-1.55%), 1.65% (1.05%-2.26%), 0.11% (0.01%-0.21%), and 0.3% (0.04%-0.55%) increases in acute AF admissions, respectively. The estimates are larger for women and older people. Stronger associations between PM2.5 and BaP concentrations and AF admissions in poorly urbanized areas were noted. Areas with high gross domestic product levels were more affected by the increase in NO2 concentrations, resulting in a 0.2% (1.001-1.003) increase in AF admissions. Exposure-response functions show steeper slopes of the pollutant-outcome associations in the lower ranges of exposures, far below World Health Organization (WHO) air quality guideline norms. For the zero-emission scenario, we estimate avoidable AF admissions - 5,873 for PM2.5 (95% CI 3,679 to 8,047) and 3,295 for NO2 (2,108-4,477).</p><p><strong>Conclusions: </strong>Air pollution acts as a triggering factor and can be associated with acute AF hospitalisations. PM2.5 and NO2 have an impact on AF even at concentrations levels below WHO air quality guideline norms.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lipoprotein (a) and atherosclerotic cardiovascular disease: does high-sensitive C-reactive protein contribute and quo vadis?","authors":"Daniel A Duprez, David R Jacobs","doi":"10.1093/eurjpc/zwaf015","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf015","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Positive medicine to prevent non-communicable disease.","authors":"Rachel E Climie, Jean-Philippe Empana","doi":"10.1093/eurjpc/zwaf003","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf003","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luigina Guasti, Stefano Fumagalli, Jonathan Afilalo, Tobias Geisler, Ana Abreu, Marco Ambrosetti, Sofie Gevaert, Ruxandra Christodorescu, Dimitri Richter, Victor Aboyans, Lucie Chastaingt, Michela Barisone, Paolo Severgnini, Riccardo Asteggiano, Marc Ferrini
Due to the aging population, focusing on healthy aging has become a global priority. Cardiovascular diseases (CVDs) and frailty, characterized by increased vulnerability to adverse stress and health events, interact synergistically in advanced age. In older adults, hip fractures are a frequent dramatic "life-transition" event. Conditions such as arrhythmias, orthostatic hypotension, heart failure, peripheral artery disease and adverse drug reactions may facilitate falls and thus bone fractures in older adults. Cardiovascular complications or the worsening of previous CVDs may increase the degree of frailty and disability following this surgery. The close relationship between older age, CVDs, frailty and orthopaedic surgery leads to the need to focus on the various phases of interventions in a multidisciplinary approach. This document aims to provide practical support to prevent cardiovascular complications in older and frail patients undergoing hip procedures by suggesting specific assessments and interventions. In particular, in pre-operative care the focus should be on the assessment and management of concomitant CVD and frailty, while immediate peri- and post-operative care should highlight specific concerns for anesthesia, prevention and management of thrombotic complications, specific nursing needs, including the prevention of infections and delirium, and the establishment of an integrated rehabilitation program focusing on CVDs and the risk of new falls, with a positive role for care-givers. Furthermore, by optimizing the "hip surgery pathway" the objective is to help avoid the deterioration of health and loss of independence that often result from this surgery through the correct management of cardiovascular patients in this peculiar context.
{"title":"Cardiovascular diseases, prevention and management of complications in older adults and frail patients treated for elective or post-traumatic hip orthopaedic interventions.","authors":"Luigina Guasti, Stefano Fumagalli, Jonathan Afilalo, Tobias Geisler, Ana Abreu, Marco Ambrosetti, Sofie Gevaert, Ruxandra Christodorescu, Dimitri Richter, Victor Aboyans, Lucie Chastaingt, Michela Barisone, Paolo Severgnini, Riccardo Asteggiano, Marc Ferrini","doi":"10.1093/eurjpc/zwaf010","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf010","url":null,"abstract":"<p><p>Due to the aging population, focusing on healthy aging has become a global priority. Cardiovascular diseases (CVDs) and frailty, characterized by increased vulnerability to adverse stress and health events, interact synergistically in advanced age. In older adults, hip fractures are a frequent dramatic \"life-transition\" event. Conditions such as arrhythmias, orthostatic hypotension, heart failure, peripheral artery disease and adverse drug reactions may facilitate falls and thus bone fractures in older adults. Cardiovascular complications or the worsening of previous CVDs may increase the degree of frailty and disability following this surgery. The close relationship between older age, CVDs, frailty and orthopaedic surgery leads to the need to focus on the various phases of interventions in a multidisciplinary approach. This document aims to provide practical support to prevent cardiovascular complications in older and frail patients undergoing hip procedures by suggesting specific assessments and interventions. In particular, in pre-operative care the focus should be on the assessment and management of concomitant CVD and frailty, while immediate peri- and post-operative care should highlight specific concerns for anesthesia, prevention and management of thrombotic complications, specific nursing needs, including the prevention of infections and delirium, and the establishment of an integrated rehabilitation program focusing on CVDs and the risk of new falls, with a positive role for care-givers. Furthermore, by optimizing the \"hip surgery pathway\" the objective is to help avoid the deterioration of health and loss of independence that often result from this surgery through the correct management of cardiovascular patients in this peculiar context.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to Letter to the Editor titled, \"Does Evolocumab treatment reduce carotid intima-media thickness in paediatric patients with heterozygous familial hypercholesterolaemia?\" by Christian Saleh.","authors":"Albert Wiegman, Frederick J Raal, Ajay K Bhatia","doi":"10.1093/eurjpc/zwaf005","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf005","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intervention is Needed in PCOS for Prevention of Cardiovascular Diseases.","authors":"Felice L Gersh, Carl J Lavie, James H O'Keefe","doi":"10.1093/eurjpc/zwaf007","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf007","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Treatment of Heterozygous Familial Hypercholesterolemia in Children: Is Lower Better?","authors":"Vera Bittner","doi":"10.1093/eurjpc/zwaf008","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf008","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Would a weekly shot be enough to solve the obesity problem? A new denial of a complex reality.","authors":"Alexandre Duparc, Philippe Terral, Olivier Lairez","doi":"10.1093/eurjpc/zwaf002","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf002","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"eSports, exergames, and eAthletes: opportunities and challenges for preventive cardiology on a global scale.","authors":"Erik Fung, Antonio Pelliccia","doi":"10.1093/eurjpc/zwae245","DOIUrl":"10.1093/eurjpc/zwae245","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"88-90"},"PeriodicalIF":8.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicholas A Koemel, Matthew N Ahmadi, Raaj Kishore Biswas, Annemarie Koster, Andrew J Atkin, Angelo Sabag, Emmanuel Stamatakis
<p><strong>Aims: </strong>Incidental physical activity as part of daily living may offer feasibility advantages over traditional exercise. We examined the joint associations of incidental physical activity and sedentary behaviour with major adverse cardiovascular events (MACE) risk.</p><p><strong>Methods and results: </strong>Analyses included 22 368 non-exercising adults from the UK Biobank accelerometry sub-study (median age [IQR]: 62.9 [11.6] years; 41.8% male). Physical activity and sedentary behaviour exposures were derived using a machine learning-based intensity and posture classification schema. We assessed the tertile-based joint associations of sedentary behaviour and the following: a) incidental vigorous (VPA), b) incidental moderate to vigorous (MVPA), c) vigorous intermittent lifestyle physical activity (VILPA; bouts lasting up to 1 min), and d) moderate to vigorous intermittent lifestyle physical activity (MV-ILPA; bouts lasting up to 3 min) with MACE risk. Over an 8.0-year median follow-up, 819 MACE events occurred. Compared to the highest physical activity and lowest sedentary time, high sedentary behaviour (>11.4 h/day) with low incidental VPA (<2.1 min/day) had an HR of 1.34 (95% CI: 0.98, 1.84) and low incidental MVPA (<21.8 min/day) had a 1.89 HR (95% CI: 1.42, 2.52) for MACE. Sedentary behaviour was not associated with MACE at medium and high levels of VPA or VILPA. Completing 4.1 min/day of VPA or VILPA may offset the MACE risk associated with high sedentary behaviour. Conversely, 31-65 min of incidental MVPA or 26-52 min of MV-ILPA per day largely attenuated the associations with MACE.</p><p><strong>Conclusion: </strong>Brief intermittent bursts of vigorous incidental physical activity may offset cardiovascular risks from high sedentary behaviour.</p><p><strong>Lay summary: </strong>Literature to date has examined the role of total or leisure time physical activity in mitigating the health risks associated with high sedentary behaviour. However, the vast majority of adults achieve their daily physical activity incidentally through day-to-day activities. In this study of 22 368 adults from the UK Biobank accelerometry sub-study, we provide the first investigation into whether a) incidental vigorous (VPA), b) incidental moderate to vigorous (MVPA), c) vigorous intermittent lifestyle physical activity (VILPA; bouts lasting up to 1 min), and d) moderate to vigorous intermittent lifestyle physical activity (MV-ILPA; bouts lasting up to 3 min) completed through normal daily living can offset the risk of major adverse cardiovascular events (MACE) associated with high sedentary behaviour (>11.4 h per day). We demonstrate that incidental VPA and MVPA may offset the MACE risk associated with high-sedentary behaviour even if accrued in brief bursts lasting <3 min. Completing 4.1 min/day of VPA or VILPA may offset the MACE risk associated with high sedentary behaviour.A daily duration of 31-65 min of incidental MVPA or 26-52 min of MV-
{"title":"Can incidental physical activity offset the deleterious associations of sedentary behaviour with major adverse cardiovascular events?","authors":"Nicholas A Koemel, Matthew N Ahmadi, Raaj Kishore Biswas, Annemarie Koster, Andrew J Atkin, Angelo Sabag, Emmanuel Stamatakis","doi":"10.1093/eurjpc/zwae316","DOIUrl":"10.1093/eurjpc/zwae316","url":null,"abstract":"<p><strong>Aims: </strong>Incidental physical activity as part of daily living may offer feasibility advantages over traditional exercise. We examined the joint associations of incidental physical activity and sedentary behaviour with major adverse cardiovascular events (MACE) risk.</p><p><strong>Methods and results: </strong>Analyses included 22 368 non-exercising adults from the UK Biobank accelerometry sub-study (median age [IQR]: 62.9 [11.6] years; 41.8% male). Physical activity and sedentary behaviour exposures were derived using a machine learning-based intensity and posture classification schema. We assessed the tertile-based joint associations of sedentary behaviour and the following: a) incidental vigorous (VPA), b) incidental moderate to vigorous (MVPA), c) vigorous intermittent lifestyle physical activity (VILPA; bouts lasting up to 1 min), and d) moderate to vigorous intermittent lifestyle physical activity (MV-ILPA; bouts lasting up to 3 min) with MACE risk. Over an 8.0-year median follow-up, 819 MACE events occurred. Compared to the highest physical activity and lowest sedentary time, high sedentary behaviour (>11.4 h/day) with low incidental VPA (<2.1 min/day) had an HR of 1.34 (95% CI: 0.98, 1.84) and low incidental MVPA (<21.8 min/day) had a 1.89 HR (95% CI: 1.42, 2.52) for MACE. Sedentary behaviour was not associated with MACE at medium and high levels of VPA or VILPA. Completing 4.1 min/day of VPA or VILPA may offset the MACE risk associated with high sedentary behaviour. Conversely, 31-65 min of incidental MVPA or 26-52 min of MV-ILPA per day largely attenuated the associations with MACE.</p><p><strong>Conclusion: </strong>Brief intermittent bursts of vigorous incidental physical activity may offset cardiovascular risks from high sedentary behaviour.</p><p><strong>Lay summary: </strong>Literature to date has examined the role of total or leisure time physical activity in mitigating the health risks associated with high sedentary behaviour. However, the vast majority of adults achieve their daily physical activity incidentally through day-to-day activities. In this study of 22 368 adults from the UK Biobank accelerometry sub-study, we provide the first investigation into whether a) incidental vigorous (VPA), b) incidental moderate to vigorous (MVPA), c) vigorous intermittent lifestyle physical activity (VILPA; bouts lasting up to 1 min), and d) moderate to vigorous intermittent lifestyle physical activity (MV-ILPA; bouts lasting up to 3 min) completed through normal daily living can offset the risk of major adverse cardiovascular events (MACE) associated with high sedentary behaviour (>11.4 h per day). We demonstrate that incidental VPA and MVPA may offset the MACE risk associated with high-sedentary behaviour even if accrued in brief bursts lasting <3 min. Completing 4.1 min/day of VPA or VILPA may offset the MACE risk associated with high sedentary behaviour.A daily duration of 31-65 min of incidental MVPA or 26-52 min of MV-","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"77-85"},"PeriodicalIF":8.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号