Pub Date : 2023-10-01Epub Date: 2023-05-11DOI: 10.1080/17461391.2023.2207079
Steffen Held, Ludwig Rappelt, Robert Rein, Tim Wiedenmann, Lars Donath
Grip and elbow flexor strength and endurance are crucial performance surrogates in competitive climbing. Thus, we examined the effects of blood flow restricted (BFR) climbing on grip and elbow flexor performance. Fifteen trained climbers (8 females; 20.8 ± 7.0 yrs; 1.72 ± 0.08 m; 63.0 ± 9.7 kg; 21.7 ± 2.7 IRCRCA grade) were either assigned to the intervention (BFR) or control (noBFR) group, using the minimization method (Strata: age, height, body mass, gender, and IRCRA grade). While BFR was used during low-intensity climbing training (2-times 10 min/session; 3-times/week), noBFR followed identical training protocols without BFR over 5 weeks. BFR of the upper limb was applied via customized pneumatic cuffs (occlusion pressure: 120 ± 23 mmHg, 75%; occlusion pressure). Endurance and strength performances were assessed via one-handed rung pulling (GripSTRENGTH), one-handed bent arm lock off at 90° (ArmSTRENGTH), static-intermitted finger hang (GripENDURANCE), and bent arm hang (ArmENDURANCE). Bayesian credible intervals revealed increased GripENDURANCE (+21 s (95% credible interval: -2 to 43 s)) and ArmENDURANCE +11 s (-5 to 27 s); adaptations via BFR. In contrast, GripSTRENGTH +4 N (-40 to 48 N) and ArmSTRENGTH +4 N (-68 to 75 N) were not affected by the BFR intervention. Fifteen cumulative sessions of BFR application with a cumulative total BFR load of 5 h over a 5 weeks macrocycle remarkably increased grip and elbow flexor endurance. Thus, BFR might serve as a promising means to improve relevant performance surrogates in trained climbers.
{"title":"Low-intensity climbing with blood flow restriction over 5 weeks increases grip and elbow flexor endurance in advanced climbers: A randomized controlled trial.","authors":"Steffen Held, Ludwig Rappelt, Robert Rein, Tim Wiedenmann, Lars Donath","doi":"10.1080/17461391.2023.2207079","DOIUrl":"10.1080/17461391.2023.2207079","url":null,"abstract":"<p><p>Grip and elbow flexor strength and endurance are crucial performance surrogates in competitive climbing. Thus, we examined the effects of blood flow restricted (BFR) climbing on grip and elbow flexor performance. Fifteen trained climbers (8 females; 20.8 ± 7.0 yrs; 1.72 ± 0.08 m; 63.0 ± 9.7 kg; 21.7 ± 2.7 IRCRCA grade) were either assigned to the intervention (BFR) or control (noBFR) group, using the minimization method (Strata: age, height, body mass, gender, and IRCRA grade). While BFR was used during low-intensity climbing training (2-times 10 min/session; 3-times/week), noBFR followed identical training protocols without BFR over 5 weeks. BFR of the upper limb was applied via customized pneumatic cuffs (occlusion pressure: 120 ± 23 mmHg, 75%; occlusion pressure). Endurance and strength performances were assessed via one-handed rung pulling (GripSTRENGTH), one-handed bent arm lock off at 90° (ArmSTRENGTH), static-intermitted finger hang (GripENDURANCE), and bent arm hang (ArmENDURANCE). Bayesian credible intervals revealed increased GripENDURANCE (+21 s (95% credible interval: -2 to 43 s)) and ArmENDURANCE +11 s (-5 to 27 s); adaptations via BFR. In contrast, GripSTRENGTH +4 N (-40 to 48 N) and ArmSTRENGTH +4 N (-68 to 75 N) were not affected by the BFR intervention. Fifteen cumulative sessions of BFR application with a cumulative total BFR load of 5 h over a 5 weeks macrocycle remarkably increased grip and elbow flexor endurance. Thus, BFR might serve as a promising means to improve relevant performance surrogates in trained climbers.</p>","PeriodicalId":12061,"journal":{"name":"European Journal of Sport Science","volume":" ","pages":"2031-2037"},"PeriodicalIF":3.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9451944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01Epub Date: 2023-02-23DOI: 10.1080/17461391.2023.2167237
Abel Plaza-Florido, Maria Rodriguez-Ayllon, Signe Altmäe, Francisco B Ortega, Irene Esteban-Cornejo
Cardiorespiratory fitness (CRF) is inversely associated with cardiovascular disease (CVD) risk factors and brain health impairments. However, the molecular mechanisms linking CRF to health in children are poorly understood. We aimed to examine protein levels related to brain health and CVD in plasma of fit compared to unfit children with overweight/obesity (OW/OB). Eighty-seven children with OW/OB (10.08 ± 1.1 years, 59% boys) from the ActiveBrains project were included. CRF was measured by performing a treadmill test, and children were categorized into fit or unfit. Targeted proteomics in plasma was performed using Olink's proximity extension assay technology of Neurology panel in the whole sample and of Cardiovascular panel in a subsample. Sixteen proteins (PLXNB3, sFRP3, CLEC1B, RSPO1, Gal8, CLEC10A, GCP5, MDGA1, CTSC, LAT, IL4RA, PRSS27, CXCL1, Gal9, MERTK, and GT) were differentially expressed between fit and unfit children with OW/OB after adjusting for sex, maturational status, and body mass index. However, statistically significant differences disappeared after applying FDR correction. Potential candidate proteins related to CRF levels in children with OW/OB were detected, being involved in several biological processes such as neurogenesis, immune/inflammatory response, signal transduction, platelet activation. Nevertheless, these preliminary findings should be confirmed or contrasted in future studies using larger sample sizes, longitudinal and experimental designs.HighlightsThe molecular mechanisms underlying the link of cardiorespiratory fitness (CRF) with cardiovascular and brain health in children with overweight/obesity (OW/OB) are poorly understood.Targeted proteomic analysis revealed differentially expressed proteins (PLXNB3, sFRP3, CLEC1B, RSPO1, Gal8, CLEC10A, GCP5, MDGA1, CTSC, LAT, IL4RA, PRSS27, CXCL1, Gal9, MERTK, and GT) in plasma of "Fit" compared to "Unfit" children with OW/OB. These proteins are involved in several biological processes such as immune/inflammatory response, neurogenesis, signal transduction, and cellular metabolic process.Longitudinal and experimental studies are warranted to reveal how improvements in CRF are related to changes in circulating levels of the abovementioned proteins and how they might reduce cardiovascular diseases risk factors and brain health impairments later in life.
{"title":"Cardiorespiratory fitness and targeted proteomics involved in brain and cardiovascular health in children with overweight/obesity.","authors":"Abel Plaza-Florido, Maria Rodriguez-Ayllon, Signe Altmäe, Francisco B Ortega, Irene Esteban-Cornejo","doi":"10.1080/17461391.2023.2167237","DOIUrl":"10.1080/17461391.2023.2167237","url":null,"abstract":"<p><p>Cardiorespiratory fitness (CRF) is inversely associated with cardiovascular disease (CVD) risk factors and brain health impairments. However, the molecular mechanisms linking CRF to health in children are poorly understood. We aimed to examine protein levels related to brain health and CVD in plasma of fit compared to unfit children with overweight/obesity (OW/OB). Eighty-seven children with OW/OB (10.08 ± 1.1 years, 59% boys) from the ActiveBrains project were included. CRF was measured by performing a treadmill test, and children were categorized into fit or unfit. Targeted proteomics in plasma was performed using Olink's proximity extension assay technology of Neurology panel in the whole sample and of Cardiovascular panel in a subsample. Sixteen proteins (PLXNB3, sFRP3, CLEC1B, RSPO1, Gal8, CLEC10A, GCP5, MDGA1, CTSC, LAT, IL4RA, PRSS27, CXCL1, Gal9, MERTK, and GT) were differentially expressed between fit and unfit children with OW/OB after adjusting for sex, maturational status, and body mass index. However, statistically significant differences disappeared after applying FDR correction. Potential candidate proteins related to CRF levels in children with OW/OB were detected, being involved in several biological processes such as neurogenesis, immune/inflammatory response, signal transduction, platelet activation. Nevertheless, these preliminary findings should be confirmed or contrasted in future studies using larger sample sizes, longitudinal and experimental designs.<b>Highlights</b>The molecular mechanisms underlying the link of cardiorespiratory fitness (CRF) with cardiovascular and brain health in children with overweight/obesity (OW/OB) are poorly understood.Targeted proteomic analysis revealed differentially expressed proteins (PLXNB3, sFRP3, CLEC1B, RSPO1, Gal8, CLEC10A, GCP5, MDGA1, CTSC, LAT, IL4RA, PRSS27, CXCL1, Gal9, MERTK, and GT) in plasma of \"Fit\" compared to \"Unfit\" children with OW/OB. These proteins are involved in several biological processes such as immune/inflammatory response, neurogenesis, signal transduction, and cellular metabolic process.Longitudinal and experimental studies are warranted to reveal how improvements in CRF are related to changes in circulating levels of the abovementioned proteins and how they might reduce cardiovascular diseases risk factors and brain health impairments later in life.</p>","PeriodicalId":12061,"journal":{"name":"European Journal of Sport Science","volume":" ","pages":"2076-2085"},"PeriodicalIF":3.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10757184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01Epub Date: 2023-05-09DOI: 10.1080/17461391.2023.2201813
Christopher E Proppe, Taylor M Aldeghi, Paola M Rivera, David Gonzalez-Rojas, Aaron M Wizenberg, Ethan C Hill
ABSTRACTThere is conflicting evidence regarding the prevalence and magnitude of exercise-induced muscle damage (EIMD) following low-load resistance exercise with blood flow restriction (LL + BFR) that may be related to exercise protocols. The purpose of this investigation was to examine the effects of 75-repetition (BFR-75) (1 × 30, 3 × 15) and 4 sets to failure (BFR-4x) protocols on indices of EIMD among untrained women. Thirteen women completed this investigation. One leg was randomly assigned to BFR-75 and the other to BFR-4x. Each leg performed isokinetic, unilateral, concentric-eccentric, leg extension muscle actions at 30% of maximal strength. Indices of EIMD (muscle soreness, range of motion [ROM], limb circumference, pain pressure threshold [PPT], and maximal voluntary isometric contraction [MVIC]) were recorded before exercise, 0-, 24-, 48-, 72-, and 96-hours post-exercise. There were no changes for ROM, circumference, or PPT. Muscle soreness increased similarly in both conditions 0-, 24-, and 48-hours post-exercise and MVIC increased 24-, 48-, 72-, and 96-hours post-exercise. These findings suggested BFR-75 and BFR-4x were not associated with EIMD and elicited similar physiological responses. The increases in muscle soreness may be due to metabolic stress associated with LL + BFR protocols apart from EIMD.
{"title":"75-repetition versus sets to failure of blood flow restriction exercise on indices of muscle damage in women.","authors":"Christopher E Proppe, Taylor M Aldeghi, Paola M Rivera, David Gonzalez-Rojas, Aaron M Wizenberg, Ethan C Hill","doi":"10.1080/17461391.2023.2201813","DOIUrl":"10.1080/17461391.2023.2201813","url":null,"abstract":"<p><p><b>ABSTRACT</b>There is conflicting evidence regarding the prevalence and magnitude of exercise-induced muscle damage (EIMD) following low-load resistance exercise with blood flow restriction (LL + BFR) that may be related to exercise protocols. The purpose of this investigation was to examine the effects of 75-repetition (BFR-75) (1 × 30, 3 × 15) and 4 sets to failure (BFR-4x) protocols on indices of EIMD among untrained women. Thirteen women completed this investigation. One leg was randomly assigned to BFR-75 and the other to BFR-4x. Each leg performed isokinetic, unilateral, concentric-eccentric, leg extension muscle actions at 30% of maximal strength. Indices of EIMD (muscle soreness, range of motion [ROM], limb circumference, pain pressure threshold [PPT], and maximal voluntary isometric contraction [MVIC]) were recorded before exercise, 0-, 24-, 48-, 72-, and 96-hours post-exercise. There were no changes for ROM, circumference, or PPT. Muscle soreness increased similarly in both conditions 0-, 24-, and 48-hours post-exercise and MVIC increased 24-, 48-, 72-, and 96-hours post-exercise. These findings suggested BFR-75 and BFR-4x were not associated with EIMD and elicited similar physiological responses. The increases in muscle soreness may be due to metabolic stress associated with LL + BFR protocols apart from EIMD.</p>","PeriodicalId":12061,"journal":{"name":"European Journal of Sport Science","volume":" ","pages":"1993-2001"},"PeriodicalIF":3.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9436490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01Epub Date: 2023-02-23DOI: 10.1080/17461391.2023.2171906
Senanile B Dlamini, Colleen J Saunders, Mary-Jessica N Laguette, Andrea Gibbon, Junaid Gamieldien, Malcolm Collins, Alison V September
ABSTRACT We developed a Biomedical Knowledge Graph model that is phenotype and biological function-aware through integrating knowledge from multiple domains in a Neo4j, graph database. All known human genes were assessed through the model to identify potential new risk genes for anterior cruciate ligament (ACL) ruptures and Achilles tendinopathy (AT). Genes were prioritised and explored in a case–control study comparing participants with ACL ruptures (ACL-R), including a sub-group with non-contact mechanism injuries (ACL-NON), to uninjured control individuals (CON). After gene filtering, 3376 genes, including 411 genes identified through previous whole exome sequencing, were found to be potentially linked to AT and ACL ruptures. Four variants were prioritised: HSPG2:rs2291826A/G, HSPG2:rs2291827G/A, ITGB2:rs2230528C/T and FGF9:rs2274296C/T. The rs2230528 CC genotype was over-represented in the CON group compared to ACL-R (p < 0.001) and ACL-NON (p < 0.001) and the TT genotype and T allele were over-represented in the ACL-R group and ACL-NON compared to CON (p < 0.001) group. Several significant differences in distributions were noted for the gene-gene interactions: (HSPG2:rs2291826, rs2291827 and ITGB2:rs2230528) and (ITGB2:rs2230528 and FGF9:rs2297429). This study substantiates the efficiency of using a prior knowledge-driven in silico approach to identify candidate genes linked to tendon and ACL injuries. Our biomedical knowledge graph identified and, with further testing, highlighted novel associations of the ITGB2 gene which has not been explored in a genetic case control association study, with ACL rupture risk. We thus recommend a multistep approach including bioinformatics in conjunction with next generation sequencing technology to improve the discovery potential of genomics technologies in musculoskeletal soft tissue injuries. Highlights A biomedical knowledge graph was modelled for musculoskeletal soft tissue injuries to efficiently identify candidate genes for genetic susceptibility analyses. The biomedical knowledge graph and sequencing data identified potential biologically relevant variants to explore susceptibility to common tendon and ligament injuries. Specifically genetic variants within the ITGB2 and FGF9 genes were associated with ACL risk. Novel allele combinations (HSPG2-ITGB2 and ITGB2-FGF9) showcase the potential effect of ITGB2 in influencing risk of ACL rupture.
我们开发了一个生物医学知识图模型,该模型通过在Neo4j图形数据库中集成多个领域的知识来感知表型和生物功能。通过该模型评估了所有已知的人类基因,以确定前交叉韧带(ACL)断裂和跟腱病(AT)的潜在新风险基因。在一项病例对照研究中,对基因进行了优先排序和探索,将ACL破裂(ACL-R)的参与者(包括非接触性机制损伤(ACL-non)的亚组)与未受伤的对照个体(CON)进行了比较。经过基因筛选,3376个基因,包括通过先前的全外显子组测序鉴定的411个基因,被发现可能与AT和ACL破裂有关。四种变体被优先考虑:HSPG2:rs2291826A/G、HSPG2:rss2291827G/A、ITGB2:rs2230528C/T和FGF9:rs2274296C/T。与ACL-R相比,CON组中rs2230528CC基因型的表达过度(p p p HSPG2:rs2291826、rs2291827和ITGB2:rs2230528)和(ITGB2:rss2230528和FGF9:rs2297429)。这项研究证实了使用先验知识驱动的计算机方法来识别与肌腱和ACL损伤相关的候选基因的效率。我们的生物医学知识图谱确定了ITGB2基因与ACL破裂风险之间的新关联,并通过进一步的测试,强调了该基因与ACL断裂风险的新关联。因此,我们建议采用包括生物信息学和下一代测序技术在内的多步骤方法,以提高基因组学技术在肌肉骨骼软组织损伤中的发现潜力。亮点肌肉骨骼软组织损伤的生物医学知识图谱被建模,以有效识别遗传易感性分析的候选基因。生物医学知识图谱和测序数据确定了潜在的生物学相关变体,以探索常见肌腱和韧带损伤的易感性。特别是ITGB2和FGF9基因内的遗传变异与ACL风险相关。新的等位基因组合(HSPG2-ITGB2和ITGB2-FGF9)显示了ITGB2在影响ACL破裂风险方面的潜在作用。
{"title":"Application of an <i>in silico</i> approach identifies a genetic locus within <i>ITGB2,</i> and its interactions with <i>HSPG2 and FGF9,</i> to be associated with anterior cruciate ligament rupture risk.","authors":"Senanile B Dlamini, Colleen J Saunders, Mary-Jessica N Laguette, Andrea Gibbon, Junaid Gamieldien, Malcolm Collins, Alison V September","doi":"10.1080/17461391.2023.2171906","DOIUrl":"10.1080/17461391.2023.2171906","url":null,"abstract":"ABSTRACT We developed a Biomedical Knowledge Graph model that is phenotype and biological function-aware through integrating knowledge from multiple domains in a Neo4j, graph database. All known human genes were assessed through the model to identify potential new risk genes for anterior cruciate ligament (ACL) ruptures and Achilles tendinopathy (AT). Genes were prioritised and explored in a case–control study comparing participants with ACL ruptures (ACL-R), including a sub-group with non-contact mechanism injuries (ACL-NON), to uninjured control individuals (CON). After gene filtering, 3376 genes, including 411 genes identified through previous whole exome sequencing, were found to be potentially linked to AT and ACL ruptures. Four variants were prioritised: HSPG2:rs2291826A/G, HSPG2:rs2291827G/A, ITGB2:rs2230528C/T and FGF9:rs2274296C/T. The rs2230528 CC genotype was over-represented in the CON group compared to ACL-R (p < 0.001) and ACL-NON (p < 0.001) and the TT genotype and T allele were over-represented in the ACL-R group and ACL-NON compared to CON (p < 0.001) group. Several significant differences in distributions were noted for the gene-gene interactions: (HSPG2:rs2291826, rs2291827 and ITGB2:rs2230528) and (ITGB2:rs2230528 and FGF9:rs2297429). This study substantiates the efficiency of using a prior knowledge-driven in silico approach to identify candidate genes linked to tendon and ACL injuries. Our biomedical knowledge graph identified and, with further testing, highlighted novel associations of the ITGB2 gene which has not been explored in a genetic case control association study, with ACL rupture risk. We thus recommend a multistep approach including bioinformatics in conjunction with next generation sequencing technology to improve the discovery potential of genomics technologies in musculoskeletal soft tissue injuries. Highlights A biomedical knowledge graph was modelled for musculoskeletal soft tissue injuries to efficiently identify candidate genes for genetic susceptibility analyses. The biomedical knowledge graph and sequencing data identified potential biologically relevant variants to explore susceptibility to common tendon and ligament injuries. Specifically genetic variants within the ITGB2 and FGF9 genes were associated with ACL risk. Novel allele combinations (HSPG2-ITGB2 and ITGB2-FGF9) showcase the potential effect of ITGB2 in influencing risk of ACL rupture.","PeriodicalId":12061,"journal":{"name":"European Journal of Sport Science","volume":" ","pages":"2098-2108"},"PeriodicalIF":3.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10757675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01Epub Date: 2023-05-01DOI: 10.1080/17461391.2023.2203107
Zachary J McKenna, Bryanne N Bellovary, Jeremy B Ducharme, Michael R Deyhle, Andrew D Wells, Zachary J Fennel, Jonathan W Specht, Jonathan M Houck, Trevor J Mayschak, Christine M Mermier
Hypoxia induced intestinal barrier injury, microbial translocation, and local/systemic inflammation may contribute to high-altitude associated gastrointestinal complications or symptoms of acute mountain sickness (AMS). Therefore, we tested the hypothesis that six-hours of hypobaric hypoxia increases circulating markers of intestinal barrier injury and inflammation. A secondary aim was to determine if the changes in these markers were different between those with and without AMS. Thirteen participants were exposed to six hours of hypobaric hypoxia, simulating an altitude of 4572 m. Participants completed two 30-minute bouts of exercise during the early hours of hypoxic exposure to mimic typical activity required by those at high altitude. Pre- and post-exposure blood samples were assessed for circulating markers of intestinal barrier injury and inflammation. Data below are presented as mean ± standard deviation or median [interquartile range]. Intestinal fatty acid binding protein (Δ251 [103-410] pg•mL-1; p = 0.002, d = 0.32), lipopolysaccharide binding protein (Δ2 ± 2.4 μg•mL-1; p = 0.011; d = 0.48), tumor necrosis factor-α (Δ10.2 [3-42.2] pg•mL-1; p = 0.005; d = 0.25), interleukin-1β (Δ1.5 [0-6.7] pg•mL-1p = 0.042; d = 0.18), and interleukin-1 receptor agonist (Δ3.4 [0.4-5.2] pg•mL-1p = 0.002; d = 0.23) increased from pre- to post-hypoxia. Six of the 13 participants developed AMS; however, the pre- to post-hypoxia changes for each marker were not different between those with and without AMS (p > 0.05 for all indices). These data provide evidence that high altitude exposures can lead to intestinal barrier injury, which may be an important consideration for mountaineers, military personnel, wildland firefighters, and athletes who travel to high altitudes to perform physical work or exercise.
{"title":"Circulating markers of intestinal barrier injury and inflammation following exertion in hypobaric hypoxia.","authors":"Zachary J McKenna, Bryanne N Bellovary, Jeremy B Ducharme, Michael R Deyhle, Andrew D Wells, Zachary J Fennel, Jonathan W Specht, Jonathan M Houck, Trevor J Mayschak, Christine M Mermier","doi":"10.1080/17461391.2023.2203107","DOIUrl":"10.1080/17461391.2023.2203107","url":null,"abstract":"<p><p>Hypoxia induced intestinal barrier injury, microbial translocation, and local/systemic inflammation may contribute to high-altitude associated gastrointestinal complications or symptoms of acute mountain sickness (AMS). Therefore, we tested the hypothesis that six-hours of hypobaric hypoxia increases circulating markers of intestinal barrier injury and inflammation. A secondary aim was to determine if the changes in these markers were different between those with and without AMS. Thirteen participants were exposed to six hours of hypobaric hypoxia, simulating an altitude of 4572 m. Participants completed two 30-minute bouts of exercise during the early hours of hypoxic exposure to mimic typical activity required by those at high altitude. Pre- and post-exposure blood samples were assessed for circulating markers of intestinal barrier injury and inflammation. Data below are presented as mean ± standard deviation or median [interquartile range]. Intestinal fatty acid binding protein (Δ251 [103-410] pg•mL<sup>-1</sup>; <i>p</i> = 0.002, d = 0.32), lipopolysaccharide binding protein (Δ2 ± 2.4 μg•mL<sup>-1</sup>; <i>p</i> = 0.011; d = 0.48), tumor necrosis factor-α (Δ10.2 [3-42.2] pg•mL<sup>-1</sup>; <i>p</i> = 0.005; d = 0.25), interleukin-1β (Δ1.5 [0-6.7] pg•mL<sup>-1</sup> <i>p</i> = 0.042; d = 0.18), and interleukin-1 receptor agonist (Δ3.4 [0.4-5.2] pg•mL<sup>-1</sup><i>p</i> = 0.002; d = 0.23) increased from pre- to post-hypoxia. Six of the 13 participants developed AMS; however, the pre- to post-hypoxia changes for each marker were not different between those with and without AMS (<i>p</i> > 0.05 for all indices). These data provide evidence that high altitude exposures can lead to intestinal barrier injury, which may be an important consideration for mountaineers, military personnel, wildland firefighters, and athletes who travel to high altitudes to perform physical work or exercise.</p>","PeriodicalId":12061,"journal":{"name":"European Journal of Sport Science","volume":" ","pages":"2002-2010"},"PeriodicalIF":3.2,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9368145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01Epub Date: 2023-05-11DOI: 10.1080/17461391.2023.2203120
Benjamin W C Jerome, Michael Stoeckl, Ben Mackriell, Thomas Seidl, Christian W Dawson, Daniel T P Fong, Jonathan P Folland
The physical demands of soccer match-play have typically been assessed using a low-resolution whole match approach ignoring whether the ball is in or out of play (BIP/BOP) and during these periods which team has possession. This study investigated the effect of fundamental match structure variables (BIP/BOP, in/out of possession) on the physical demands, and especially intensity, of elite match-play. For 1083 matches from a major European league, whole match duration, and player physical tracking data, were divided into BIP/BOP, and in/out of possession periods throughout the match, using on-ball event data. These distinct phases were used to derive absolute (m) and rate (m·min-1) of distance covered in total and within six speed categories during BIP/BOP and in/out possession. The rate of distance covered, an index of physical intensity, was >2-fold greater during BIP vs BOP. Whole match total distance covered was confounded by BIP time and poorly associated with physical intensity during BIP (r = 0.36). Whole match rates of distance covered substantially underestimated those during BIP, particularly for higher running speeds (∼-62%). Ball possession markedly effected physical intensity, with the rates of distance covered running (+31%), at high-speed (+30%) and in total (+7%) greater out than in possession. Whole match physical metrics underestimated the physical intensity during BIP, and thus the rate(s) of distance covered during BIP are recommended for accurate measurement of physical intensity in elite soccer. The greater demands of being out of possession support a possession-based tactical approach to minimise fatigue and its negative consequences.
{"title":"The influence of ball in/out of play and possession in elite soccer: Towards a more valid measure of physical intensity during competitive match-play.","authors":"Benjamin W C Jerome, Michael Stoeckl, Ben Mackriell, Thomas Seidl, Christian W Dawson, Daniel T P Fong, Jonathan P Folland","doi":"10.1080/17461391.2023.2203120","DOIUrl":"10.1080/17461391.2023.2203120","url":null,"abstract":"<p><p>The physical demands of soccer match-play have typically been assessed using a low-resolution whole match approach ignoring whether the ball is in or out of play (BIP/BOP) and during these periods which team has possession. This study investigated the effect of fundamental match structure variables (BIP/BOP, in/out of possession) on the physical demands, and especially intensity, of elite match-play. For 1083 matches from a major European league, whole match duration, and player physical tracking data, were divided into BIP/BOP, and in/out of possession periods throughout the match, using on-ball event data. These distinct phases were used to derive absolute (m) and rate (m·min<sup>-1</sup>) of distance covered in total and within six speed categories during BIP/BOP and in/out possession. The rate of distance covered, an index of physical intensity, was >2-fold greater during BIP vs BOP. Whole match total distance covered was confounded by BIP time and poorly associated with physical intensity during BIP (<i>r </i>= 0.36). Whole match rates of distance covered substantially underestimated those during BIP, particularly for higher running speeds (∼-62%). Ball possession markedly effected physical intensity, with the rates of distance covered running (+31%), at high-speed (+30%) and in total (+7%) greater out than in possession. Whole match physical metrics underestimated the physical intensity during BIP, and thus the rate(s) of distance covered during BIP are recommended for accurate measurement of physical intensity in elite soccer. The greater demands of being out of possession support a possession-based tactical approach to minimise fatigue and its negative consequences.</p>","PeriodicalId":12061,"journal":{"name":"European Journal of Sport Science","volume":" ","pages":"1892-1902"},"PeriodicalIF":3.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9573068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01Epub Date: 2022-12-18DOI: 10.1080/17461391.2022.2144765
Luke Nicholas Woodhouse, Mark Bennett, Jamie Tallent, Stephen David Patterson, Mark Waldron
This study investigated whether anthropometric and physical abilities explained variance in match collision performance among international female rugby union players. Physical performance and anthropometric data for fifty-one international female rugby union players, and collision actions categorised as "effort" or "performance" variables, from 20 international matches, were analysed using partial least squares regression. Among forwards, variance in carries/min was explained (R2 = .22) by a combination of; body mass, skinfolds, acceleration momentum and negative associations with mean aerobic speed and single-leg isometric squat relative force (SLISO/kgBM). Variance in collision dominance among forwards was explained (R2 = .21) by lower skinfolds and higher acceleration momentum, while tackles/min (R2 = .19) were explained by greater jumping power and single-leg isometric squat (SLISO). Among backs, variance in tackles/min (R2 = .54) was explained by greater bench press, SLISO and SLISO/kgBM. Variance in collision dominance among backs was explained (R2 = .23) by negative and positive associations with body mass and SLISO/kgBM, respectively. These findings suggest the development of physical characteristics, such as body mass and composition, strength and power contribute towards successful collision actions among international female rugby union players. The contribution of different physical characteristics towards collision events is dependent on position, and whether the collision event is categorised by "performance" or "effort". It is suggested that physical training programmes should reflect this level of specificity.HighlightsAmong elite female rugby union forwards, acceleration momentum, body mass and skinfolds are positively associated with winning collisions and carrying the ball into contact more frequently, whilst tackle frequency is positively associated with relative leg strength and power output.Among elite female backs, the ability to win collisions is positively associated with relative leg power output, and negatively associated with body mass. Tackle frequency is associated with maximum upper- and lower-body strength in this group.Physical characteristics account for some of the variability in collision performance, but interpretation of these findings should consider that factors such as technique during collision events may account for a larger proportion of total variance.Sports science practitioners can improve collision performance, to varying degrees, by enhancing specific gross physical characteristics, according to a player's position and the tactical role they are expected to fulfil.
{"title":"The relationship between physical characteristics and match collision performance among elite international female rugby union players.","authors":"Luke Nicholas Woodhouse, Mark Bennett, Jamie Tallent, Stephen David Patterson, Mark Waldron","doi":"10.1080/17461391.2022.2144765","DOIUrl":"10.1080/17461391.2022.2144765","url":null,"abstract":"<p><p>This study investigated whether anthropometric and physical abilities explained variance in match collision performance among international female rugby union players. Physical performance and anthropometric data for fifty-one international female rugby union players, and collision actions categorised as \"effort\" or \"performance\" variables, from 20 international matches, were analysed using partial least squares regression. Among forwards, variance in carries/min was explained (R<sup>2 </sup>= .22) by a combination of; body mass, skinfolds, acceleration momentum and negative associations with mean aerobic speed and single-leg isometric squat relative force (SLISO/kgBM). Variance in collision dominance among forwards was explained (R<sup>2</sup> = .21) by lower skinfolds and higher acceleration momentum, while tackles/min (R<sup>2</sup> = .19) were explained by greater jumping power and single-leg isometric squat (SLISO). Among backs, variance in tackles/min (R<sup>2</sup> = .54) was explained by greater bench press, SLISO and SLISO/kgBM. Variance in collision dominance among backs was explained (R<sup>2</sup> = .23) by negative and positive associations with body mass and SLISO/kgBM, respectively. These findings suggest the development of physical characteristics, such as body mass and composition, strength and power contribute towards successful collision actions among international female rugby union players. The contribution of different physical characteristics towards collision events is dependent on position, and whether the collision event is categorised by \"performance\" or \"effort\". It is suggested that physical training programmes should reflect this level of specificity.<b>Highlights</b>Among elite female rugby union forwards, acceleration momentum, body mass and skinfolds are positively associated with winning collisions and carrying the ball into contact more frequently, whilst tackle frequency is positively associated with relative leg strength and power output.Among elite female backs, the ability to win collisions is positively associated with relative leg power output, and negatively associated with body mass. Tackle frequency is associated with maximum upper- and lower-body strength in this group.Physical characteristics account for some of the variability in collision performance, but interpretation of these findings should consider that factors such as technique during collision events may account for a larger proportion of total variance.Sports science practitioners can improve collision performance, to varying degrees, by enhancing specific gross physical characteristics, according to a player's position and the tactical role they are expected to fulfil.</p>","PeriodicalId":12061,"journal":{"name":"European Journal of Sport Science","volume":" ","pages":"1849-1858"},"PeriodicalIF":3.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10380640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01Epub Date: 2022-12-30DOI: 10.1080/17461391.2022.2150896
Samuel T Tebeck, Jonathan D Buckley, Jamie Stanley
ABSTRACT This study evaluated relationships between changes in training load, haematological responses, and endurance exercise performance during temperate and heat acclimation (HA) training preceding a male team cycling pursuit world record (WR). Haemoglobin mass (Hbmass) and concentration ([Hb]), plasma volume (PV) and blood volume (BV) were assessed in nine male track endurance cyclists (∼3 occasions per month) training in temperate conditions (247–142 days prior to the WR) to establish responses to differing acute (ATL) and chronic (CTL) training loads. Testing was performed again pre- and post-HA (22–28 days prior to the WR). Endurance performance (V̇O₂max, 4MMP, lactate threshold 1 and 2) was assessed on three occasions (238–231, 189–182 and 133–126 days prior to the WR). In temperate conditions, CTL was associated with Hbmass (B = 0.62, P = 0.02), PV (B = 4.49, P = 0.01) and BV (B = 6.51, P = 0.04) but not [Hb] (B = −0.01, P = 0.17). ATL was associated with PV (B = 2.28, P < 0.01), BV (B = 2.63, P = 0.04) and [Hb] (B = −0.01, P = 0.04) but not Hbmass (B = 0.10, P = 0.41). During HA, PV increased 8.2% (P < 0.01), while Hbmass, CTL and ATL were unchanged. Hbmass and [Hb] were associated with all performance outcomes (P < 0.05), except V̇O2max. PV and BV were not associated with performance outcomes. During temperate training, changes in Hbmass were most strongly associated with changes in CTL. Both CTL and ATL were associated with changes in PV, but HA was associated with increased PV and maintenance of Hbmass without increasing ATL or CTL. In practical terms, maintaining high CTL and high Hbmass might be beneficial for improving endurance performance. HIGHLIGHTS Changes in haemoglobin mass were associated with endurance exercise performance and changes in chronic training load in temperate conditions. Heat acclimation increased plasma volume and maintained haemoglobin mass independently of chronic training load. Chronic training loads and haemoglobin mass should be increased to improve endurance exercise performance. Heat acclimation may optimise haematological adaptations when training load is reduced
{"title":"Longitudinal haematological responses to training load and heat acclimation preceding a male team pursuit cycling world record.","authors":"Samuel T Tebeck, Jonathan D Buckley, Jamie Stanley","doi":"10.1080/17461391.2022.2150896","DOIUrl":"10.1080/17461391.2022.2150896","url":null,"abstract":"ABSTRACT This study evaluated relationships between changes in training load, haematological responses, and endurance exercise performance during temperate and heat acclimation (HA) training preceding a male team cycling pursuit world record (WR). Haemoglobin mass (Hbmass) and concentration ([Hb]), plasma volume (PV) and blood volume (BV) were assessed in nine male track endurance cyclists (∼3 occasions per month) training in temperate conditions (247–142 days prior to the WR) to establish responses to differing acute (ATL) and chronic (CTL) training loads. Testing was performed again pre- and post-HA (22–28 days prior to the WR). Endurance performance (V̇O₂max, 4MMP, lactate threshold 1 and 2) was assessed on three occasions (238–231, 189–182 and 133–126 days prior to the WR). In temperate conditions, CTL was associated with Hbmass (B = 0.62, P = 0.02), PV (B = 4.49, P = 0.01) and BV (B = 6.51, P = 0.04) but not [Hb] (B = −0.01, P = 0.17). ATL was associated with PV (B = 2.28, P < 0.01), BV (B = 2.63, P = 0.04) and [Hb] (B = −0.01, P = 0.04) but not Hbmass (B = 0.10, P = 0.41). During HA, PV increased 8.2% (P < 0.01), while Hbmass, CTL and ATL were unchanged. Hbmass and [Hb] were associated with all performance outcomes (P < 0.05), except V̇O2max. PV and BV were not associated with performance outcomes. During temperate training, changes in Hbmass were most strongly associated with changes in CTL. Both CTL and ATL were associated with changes in PV, but HA was associated with increased PV and maintenance of Hbmass without increasing ATL or CTL. In practical terms, maintaining high CTL and high Hbmass might be beneficial for improving endurance performance. HIGHLIGHTS Changes in haemoglobin mass were associated with endurance exercise performance and changes in chronic training load in temperate conditions. Heat acclimation increased plasma volume and maintained haemoglobin mass independently of chronic training load. Chronic training loads and haemoglobin mass should be increased to improve endurance exercise performance. Heat acclimation may optimise haematological adaptations when training load is reduced","PeriodicalId":12061,"journal":{"name":"European Journal of Sport Science","volume":" ","pages":"1859-1867"},"PeriodicalIF":3.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10801761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01Epub Date: 2023-05-14DOI: 10.1080/17461391.2023.2201812
Andrew Burns, Dave Collins
Performance support teams are increasingly comprised of sub-disciplines, bringing varied expertise to support an athlete or team in achieving the desired result. With more voices in the room, however, there is a need to investigate how these individuals can effectively work together collaboratively. Accordingly, the present study reviewed empirical articles that have examined interdisciplinary practice in performance sport. In total, 22 articles met the full inclusion criteria. We discuss the four key themes that emerged from the literature linked to these contexts: namely, Theoretical frameworks, Facilitative leadership and culture, Organisational and logistical structure and processes, and Personal and interpersonal qualities. To deepen the understanding in this intricate field, conducting future research such as longitudinal studies that follow team working practices over time and delve into the lived experiences of teams, as well as the perspectives of various stakeholders, would be beneficial.
{"title":"Interdisciplinary practice in performance sport: A scoping review of evidence of collaboration.","authors":"Andrew Burns, Dave Collins","doi":"10.1080/17461391.2023.2201812","DOIUrl":"10.1080/17461391.2023.2201812","url":null,"abstract":"<p><p>Performance support teams are increasingly comprised of sub-disciplines, bringing varied expertise to support an athlete or team in achieving the desired result. With more voices in the room, however, there is a need to investigate how these individuals can effectively work together collaboratively. Accordingly, the present study reviewed empirical articles that have examined interdisciplinary practice in performance sport. In total, 22 articles met the full inclusion criteria. We discuss the four key themes that emerged from the literature linked to these contexts: namely, <i>Theoretical frameworks, Facilitative leadership and culture, Organisational and logistical structure and processes, and Personal and interpersonal qualities</i>. To deepen the understanding in this intricate field, conducting future research such as longitudinal studies that follow team working practices over time and delve into the lived experiences of teams, as well as the perspectives of various stakeholders, would be beneficial.</p>","PeriodicalId":12061,"journal":{"name":"European Journal of Sport Science","volume":" ","pages":"1877-1891"},"PeriodicalIF":3.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9457652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01Epub Date: 2022-12-28DOI: 10.1080/17461391.2022.2153084
Tor Söderström, Alex C Garn
Drawing on data from the present and former football players (N = 1026) selected to a national football talent programme at the age of 15, this study explores a model of sport specialisation. We examined three specific aspects of sport specialisation including early football specialisation, participation in youth elite football training environments (i.e. academies) and enrolment in upper secondary football specialisation schools. Antecedents of these sport specialisation factors included gender (i.e. sociocultural), grit (i.e. personality) and perceptions of family finances (i.e. social). Outcomes focused on adult football participation at the age of 21 including elite skill acquisition (i.e. playing elite football) and personal development (i.e. participation in non-elite football). Findings revealed that females were less likely to gain access to elite football training or school specialisation environments. There was also a positive association between grit and participation in elite training environments. In terms of outcomes, players, who got trained in elite training environments during adolescence, were twice as likely to play elite football at the age of 21, while those who attended football specialisation schools were more likely to participate in non-elite football at the age of 21. Early specialisation was not associated with either adult participation outcome. This is one of the few studies to date addressing diverse antecedents and outcomes of sport specialisation factors. Understanding how sport specialisation practices relate to future skill acquisition and personal development can provide guidance for maximising the benefits of youth sport programming.HighlightsGirls had less opportunity to participate in elite training environments and school football classes.Early specialisation was unrelated to elite football participation at the age of 21.Participation in youth elite training increased the likelihood of elite status as an adult.Need for closer examination of sport specialisation disparities for female players.
{"title":"Sport specialization in Swedish football players: Investigating a model of antecedents and outcomes.","authors":"Tor Söderström, Alex C Garn","doi":"10.1080/17461391.2022.2153084","DOIUrl":"10.1080/17461391.2022.2153084","url":null,"abstract":"<p><p>Drawing on data from the present and former football players (<i>N </i>= 1026) selected to a national football talent programme at the age of 15, this study explores a model of sport specialisation. We examined three specific aspects of sport specialisation including early football specialisation, participation in youth elite football training environments (i.e. academies) and enrolment in upper secondary football specialisation schools. Antecedents of these sport specialisation factors included gender (i.e. sociocultural), grit (i.e. personality) and perceptions of family finances (i.e. social). Outcomes focused on adult football participation at the age of 21 including elite skill acquisition (i.e. playing elite football) and personal development (i.e. participation in non-elite football). Findings revealed that females were less likely to gain access to elite football training or school specialisation environments. There was also a positive association between grit and participation in elite training environments. In terms of outcomes, players, who got trained in elite training environments during adolescence, were twice as likely to play elite football at the age of 21, while those who attended football specialisation schools were more likely to participate in non-elite football at the age of 21. Early specialisation was not associated with either adult participation outcome. This is one of the few studies to date addressing diverse antecedents and outcomes of sport specialisation factors. Understanding how sport specialisation practices relate to future skill acquisition and personal development can provide guidance for maximising the benefits of youth sport programming.<b>Highlights</b>Girls had less opportunity to participate in elite training environments and school football classes.Early specialisation was unrelated to elite football participation at the age of 21.Participation in youth elite training increased the likelihood of elite status as an adult.Need for closer examination of sport specialisation disparities for female players.</p>","PeriodicalId":12061,"journal":{"name":"European Journal of Sport Science","volume":" ","pages":"1868-1876"},"PeriodicalIF":3.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10444297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}