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Assessment of the Long-Term Exposure to Lead in Four European Countries Using PBPK Modeling 使用PBPK模型评估四个欧洲国家的长期铅暴露
IF 6.7 3区 环境科学与生态学 Q1 Medicine Pub Date : 2023-01-28 DOI: 10.1007/s12403-023-00535-2
Moustapha Sy, D. Eleftheriadou, Christian Jung, O. Lindtner, S. Karakitsios, D. Sarigiannis, Till Weber, M. Kolossa-Gehring, M. Greiner
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引用次数: 2
Assessment of Cadmium Concentrations in Foodstuffs and Dietary Exposure Risk Across China: A Metadata Analysis 中国食品中镉浓度和膳食暴露风险评估:元数据分析
IF 6.7 3区 环境科学与生态学 Q1 Medicine Pub Date : 2023-01-17 DOI: 10.1007/s12403-022-00530-z
Y. Qing, Yongzhen Li, Xinyi Cai, Wenting He, Shishi Liu, Yunhe Ji, Meng Jiang, Linjing Yang, Jutao Wang, Siyuan Ping, Y. Chen, Yingyi Luo, Yanfei Li
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引用次数: 3
Integrated Insights into Source Apportionment and Source-Specific Health Risks of Potential Pollutants in Urban Park Soils on the Karst Plateau, SW China. 中国西南喀斯特高原城市公园土壤中潜在污染物的源分配和特定源健康风险的综合见解。
IF 6.7 3区 环境科学与生态学 Q1 Medicine Pub Date : 2023-01-07 DOI: 10.1007/s12403-023-00534-3
Longchao Liang, Yaru Zhu, Xiaohang Xu, Wanbin Hao, Jialiang Han, Zhuo Chen, Xian Dong, Guangle Qiu

Polycyclic aromatic hydrocarbons (PAHs) and heavy metal(loid)s (HMs) pose risks to environmental and human health. Identification of priority control contaminants is important in guiding the management and control of these synchronous pollutants. A total of 247 soil samples were collected from 64 urban parks in the karst plateau city of Guiyang in SW China to determine the concentrations, spatial distributions, and health risks of PAHs and HMs. The results indicate that dibenz(ah)anthracene and benzo(a)pyrene are the main PAHs species of high ecological risk, and Cr, Mn, and Ni pose elevated ecological risk among the HMs. Four sources were identified for PAHs (biomass burning, coke oven, traffic sources, and coal burning) and HMs (traffic sources, coal burning, industrial sources, and natural sources). The non-carcinogenic risk (NCR) and total carcinogenic risk (TCR) of PAHs were all determined to be negligible and at acceptable levels, several orders of magnitude below those of HMs. The NCR and TCR values of HMs were relatively high, especially for children (11.9% of NCR > 1; 79.1% of TCR > 10-4). Coal burning and natural sources make the greatest contributions to the NCR and TCR values from karst park soils in Guiyang. Considering HMs bioavailability, NCR and TCR values were rather low, due to the high residual HM fractions. Integrated insights into source specific ecological and human health risk indicate future directions for management and control of synchronous PAH and HM pollution, particularly for karst plateau areas.

Supplementary information: The online version contains supplementary material available at 10.1007/s12403-023-00534-3.

多环芳烃(PAHs)和重金属(HMs)对环境和人类健康构成风险。确定优先控制污染物对于指导这些同步污染物的管理和控制非常重要。研究人员从中国西南部喀斯特高原城市贵阳的 64 个城市公园中采集了 247 份土壤样本,以确定多环芳烃和 HMs 的浓度、空间分布和健康风险。结果表明,二苯并(ah)蒽和苯并(a)芘是具有高生态风险的主要多环芳烃,而铬、锰和镍在 HMs 中具有较高的生态风险。多环芳烃有四个来源(生物质燃烧、焦炉、交通源和燃煤),而 HMs 有四个来源(交通源、燃煤、工业源和自然源)。经测定,多环芳烃的非致癌风险 (NCR) 和总致癌风险 (TCR) 均可忽略不计,处于可接受水平,比 HMs 低几个数量级。HMs 的 NCR 和 TCR 值相对较高,尤其是对儿童而言(11.9% 的 NCR > 1;79.1% 的 TCR > 10-4)。燃煤和天然来源对贵阳岩溶公园土壤中 HMs 的 NCR 和 TCR 值贡献最大。考虑到 HMs 的生物利用率,NCR 和 TCR 值相当低,这是因为 HMs 的残留量较高。对特定污染源的生态和人类健康风险的综合分析,为未来多环芳烃和HM同步污染的管理和控制指明了方向,尤其是在岩溶高原地区:在线版本包含补充材料,可查阅 10.1007/s12403-023-00534-3。
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引用次数: 0
Characterization, Source Apportionment and Health Risk Assessment of Trace Metals in Groundwater of Metropolitan Area in Lahore, Pakistan 巴基斯坦拉合尔市区地下水痕量金属特征、来源分析及健康风险评价
IF 6.7 3区 环境科学与生态学 Q1 Medicine Pub Date : 2023-01-05 DOI: 10.1007/s12403-022-00531-y
Yasir Khan, M. Toqeer, M. Shah
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引用次数: 2
Breast Cancer Molecular Subtypes and Supervised Analysis of Urinary Metal Mixtures in Mexican Women 墨西哥妇女乳腺癌分子亚型和尿液金属混合物的监督分析
IF 6.7 3区 环境科学与生态学 Q1 Medicine Pub Date : 2023-01-03 DOI: 10.1007/s12403-022-00532-x
Ángel Mérida-Ortega, C. Gennings, S. Rothenberg, M. Cebrián, L. López-Carrillo
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引用次数: 0
To Waste or Not to Waste: Questioning Potential Health Risks of Micro- and Nanoplastics with a Focus on Their Ingestion and Potential Carcinogenicity. 浪费还是不浪费?质疑微塑料和纳米塑料的潜在健康风险,重点关注其摄入和潜在致癌性。
IF 4.5 3区 环境科学与生态学 Q1 WATER RESOURCES Pub Date : 2023-01-01 Epub Date: 2022-03-22 DOI: 10.1007/s12403-022-00470-8
Elisabeth S Gruber, Vanessa Stadlbauer, Verena Pichler, Katharina Resch-Fauster, Andrea Todorovic, Thomas C Meisel, Sibylle Trawoeger, Oldamur Hollóczki, Suzanne D Turner, Wolfgang Wadsak, A Dick Vethaak, Lukas Kenner

Micro- and nanoplastics (MNPs) are recognized as emerging contaminants, especially in food, with unknown health significance. MNPs passing through the gastrointestinal tract have been brought in context with disruption of the gut microbiome. Several molecular mechanisms have been described to facilitate tissue uptake of MNPs, which then are involved in local inflammatory and immune responses. Furthermore, MNPs can act as potential transporters ("vectors") of contaminants and as chemosensitizers for toxic substances ("Trojan Horse effect"). In this review, we summarize current multidisciplinary knowledge of ingested MNPs and their potential adverse health effects. We discuss new insights into analytical and molecular modeling tools to help us better understand the local deposition and uptake of MNPs that might drive carcinogenic signaling. We present bioethical insights to basically re-consider the "culture of consumerism." Finally, we map out prominent research questions in accordance with the Sustainable Development Goals of the United Nations.

微塑料和纳米塑料(MNPs)被认为是新出现的污染物,尤其是在食品中,其对健康的影响尚不清楚。通过胃肠道的 MNP 与肠道微生物群的破坏有关。目前已描述了几种促进组织吸收 MNPs 的分子机制,这些 MNPs 随后参与了局部炎症和免疫反应。此外,MNPs 还可作为污染物的潜在转运体("载体")和有毒物质的化敏剂("特洛伊木马效应")。在本综述中,我们总结了目前有关摄入的 MNPs 及其潜在不良健康影响的多学科知识。我们讨论了对分析和分子建模工具的新见解,这些工具可帮助我们更好地了解可能驱动致癌信号的 MNPs 的局部沉积和吸收。我们提出了生物伦理方面的见解,以便从根本上重新考虑 "消费主义文化"。最后,我们根据联合国的可持续发展目标提出了突出的研究问题。
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引用次数: 0
Leveraging Systematic Reviews to Explore Disease Burden and Costs of Per- and Polyfluoroalkyl Substance Exposures in the United States. 利用系统评价来探索美国全氟烷基和多氟烷基物质暴露的疾病负担和成本。
IF 6.7 3区 环境科学与生态学 Q1 Medicine Pub Date : 2023-01-01 Epub Date: 2022-07-26 DOI: 10.1007/s12403-022-00496-y
Vladislav Obsekov, Linda G Kahn, Leonardo Trasande

Accelerating evidence confirms the contribution of per- and polyfluoroalkyl substances (PFAS) to disease burden and disability across the lifespan. Given that policy makers raise the high cost of remediation and of substituting PFAS with safer alternatives in consumer products as barriers to confronting adverse health outcomes associated with PFAS exposure, it is important to document the costs of inaction even in the presence of uncertainty. We therefore quantified disease burdens and related economic costs due to legacy PFAS exposures in the US in 2018. We leveraged systematic reviews and used meta-analytic inputs whenever possible, identified previously published exposure-response relationships, and calculated PFOA- and PFOS-attributable increases in 13 conditions. These increments were then applied to census data to determine total annual PFOA- and PFOS-attributable cases of disease, from which we calculated economic costs due to medical care and lost productivity using previously published cost-of-illness data. We identified PFAS-attributable disease costs in the US of $5.52 billion across five primary disease endpoints shown to be associated with PFAS exposure in meta-analyses. This estimate represented the lower bound, with sensitivity analyses revealing as much as $62.6 billion in overall costs. While further work is needed to assess probability of causation and establish with greater certainty effects of the broader category of PFAS, the results confirm further that public health and policy interventions are still necessary to reduce exposure to PFOA and PFOS and their endocrine-disrupting effects. This study demonstrates the large potential economic implications of regulatory inaction.

Supplementary information: The online version contains supplementary material available at 10.1007/s12403-022-00496-y.

越来越多的证据证实,全氟烷基和多氟烷基物质(PFAS)在整个生命周期内对疾病负担和残疾的贡献。鉴于政策制定者提高了补救成本,并在消费品中用更安全的替代品取代全氟辛烷磺酸,这是应对与全氟辛烷酸暴露相关的不良健康后果的障碍,因此,即使在存在不确定性的情况下,也必须记录不作为的成本。因此,我们量化了2018年美国遗留PFAS暴露造成的疾病负担和相关经济成本。我们利用系统审查,尽可能使用荟萃分析输入,确定了先前公布的暴露-反应关系,并计算了13种情况下全氟辛烷磺酸和全氟辛烷值的增加。然后将这些增量应用于人口普查数据,以确定全氟辛烷磺酸和全氟辛烷酸可归因的年度疾病总病例,根据这些病例,我们使用先前公布的疾病成本数据计算了医疗保健和生产力损失造成的经济成本。我们在荟萃分析中发现,五个主要疾病终点的PFAS可归因疾病成本为55.2亿美元,与PFAS暴露有关。这一估计值代表了下限,敏感性分析显示总成本高达626亿美元。尽管还需要进一步的工作来评估因果关系的可能性,并更确定地确定更广泛类别的全氟辛烷磺酸的影响,但研究结果进一步证实,公共卫生和政策干预措施对于减少接触全氟辛烷酸和全氟辛烷氧及其内分泌干扰影响仍然是必要的。这项研究表明了监管不作为的巨大潜在经济影响。补充信息:在线版本包含补充材料,可访问10.1007/s12403-022-00496-y。
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引用次数: 0
Dietary Exposure to Essential and Non-essential Elements During Infants' First Year of Life in the New Hampshire Birth Cohort Study. 新罕布夏出生队列研究中婴儿第一年饮食中必需和非必需元素的暴露。
IF 4.5 3区 环境科学与生态学 Q1 WATER RESOURCES Pub Date : 2023-01-01 Epub Date: 2022-06-16 DOI: 10.1007/s12403-022-00489-x
Antonio J Signes-Pastor, Vicki Sayarath, Brian Jackson, Kathryn L Cottingham, Tracy Punshon, Margaret R Karagas

Even the low levels of non-essential elements exposure common in the US may have health consequences especially early in life. However, little is known about the infant's dynamic exposure to essential and non-essential elements. This study aims to evaluate exposure to essential and non-essential elements during infants' first year of life and to explore the association between the exposure and rice consumption. Paired urine samples from infants enrolled in the New Hampshire Birth Cohort Study (NHBCS) were collected at approximately 6 weeks (exclusively breastfed) and at 1 year of age after weaning (n = 187). A further independent subgroup of NHBCS infants with details about rice consumption at 1 year of age also was included (n = 147). Urinary concentrations of 8 essential (Co, Cr, Cu, Fe, Mn, Mo, Ni, and Se) and 9 non-essential (Al, As, Cd, Hg, Pb, Sb, Sn, V, and U) elements were determined as a measure of exposure. Several essential (Co, Fe, Mo, Ni, and Se) and non-essential (Al, As, Cd, Hg, Pb, Sb, Sn, and V) elements had higher concentrations at 1 year than at 6 weeks of age. The highest increases were for urinary As and Mo with median concentrations of 0.20 and 1.02 µg/L at 6 weeks and 2.31 and 45.36 µg/L at 1 year of age, respectively. At 1 year of age, As and Mo urine concentrations were related to rice consumption. Further efforts are necessary to minimize exposure to non-essential elements while retaining essential elements to protect and promote children's health.

Supplementary information: The online version contains supplementary material available at 10.1007/s12403-022-00489-x.

即使是美国常见的低水平非必需元素暴露也可能对健康产生影响,尤其是在生命早期。然而,关于婴儿动态暴露于必要和非必要元素的情况知之甚少。本研究旨在评估婴儿一岁时接触必需元素和非必需元素的情况,并探讨接触量与大米摄入量之间的关系。在新罕布什尔出生队列研究(NHBCS)中登记的婴儿在大约6周(纯母乳喂养)和断奶后1岁(n = 187)时收集成对尿液样本。另一个独立的新生儿亚组,包括1岁时的大米消费细节(n = 147)。8种必需元素(Co、Cr、Cu、Fe、Mn、Mo、Ni和Se)和9种非必需元素(Al、As、Cd、Hg、Pb、Sb、Sn、V和U)的尿浓度被测定为暴露的量度。一些必需元素(Co、Fe、Mo、Ni和Se)和非必需元素(Al、As、Cd、Hg、Pb、Sb、Sn和V)在一岁时的浓度高于6周龄时的浓度。尿中As和Mo浓度增加最多,6周时中位浓度分别为0.20和1.02µg/L, 1岁时中位浓度分别为2.31和45.36µg/L。1岁时,尿中砷和钼浓度与大米食用量有关。必须进一步努力尽量减少接触非基本元素,同时保留基本元素,以保护和促进儿童健康。补充信息:在线版本包含补充资料,提供地址为10.1007/s12403-022-00489-x。
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引用次数: 0
Spatial-Temporal Variation and Health Risk Assessment of Fluoride in Surface Water in the Tibetan Plateau. 青藏高原地表水氟化物时空变化及健康风险评价
IF 6.7 3区 环境科学与生态学 Q1 Medicine Pub Date : 2023-01-01 DOI: 10.1007/s12403-022-00490-4
Yi Yang, Ru Zhang, Fengying Zhang, Yonghua Li

The Tibetan Plateau (TP) is known as the "Asian Water Tower" and provides vital drinking water for residents of China and Southeast Asian countries. However, large-scale regional research on water quality in this climate-sensitive and ecologically-fragile area is still lacking. Considering that drinking from fluoride-contaminated water poses serious health concerns worldwide, especially in Asian counties, it is urgent to clarify the spatial-temporal distribution characteristics, influencing factors, and health risk of fluoride in surface water in the TP. In this study, a total of 2697 surface water samples from major rivers and typical lakes in the TP were systematically analysed. Overall, fluoride concentrations ranged from 0.003 to 6.240 mg L-1 and varied among water periods, water basins and even water types. Pearson's correlation analysis showed that the distribution of fluoride concentration was closely related to the regional climate and positively correlated with anthropogenic activities. Probabilistic health risk assessment revealed that potential hazards in the Inner Basin were the highest for all age groups (HR > 1), especially for infants and adults (HR > 3), while the risks in most other water basins were acceptable (HR < 1). Our findings can provide scientific support for fluorosis prevention, and guide water resource utilization in the TP and adjacent regions.

Supplementary information: The online version contains supplementary material available at 10.1007/s12403-022-00490-4.

青藏高原(TP)被称为“亚洲水塔”,为中国和东南亚国家的居民提供重要的饮用水。然而,在这一气候敏感和生态脆弱地区,大规模的区域水质研究仍然缺乏。在世界范围内,特别是在亚洲国家,饮用氟污染的水是严重的健康问题,迫切需要澄清TP地表水中氟的时空分布特征、影响因素和健康风险。本研究对青藏高原主要河流和典型湖泊的2697份地表水样本进行了系统分析。总体而言,氟化物浓度在0.003至6.240 mg L-1之间,并因水期、流域甚至水类型而异。Pearson相关分析表明,氟浓度分布与区域气候密切相关,与人为活动正相关。概率健康风险评估显示,盆地内所有年龄组的潜在危害最高(HR > 1),特别是婴儿和成人(HR > 3),而大多数其他流域的风险是可以接受的(HR补充信息:在线版本包含补充资料,可在10.1007/s12403-022-00490-4获得)。
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引用次数: 7
A Systematic Workflow of Data Mining Confirms Widespread Occurrence of Antibiotic Contamination in Freshwater Reservoirs 数据挖掘的系统工作流程证实了淡水水库中抗生素污染的普遍存在
IF 6.7 3区 环境科学与生态学 Q1 Medicine Pub Date : 2022-12-23 DOI: 10.1007/s12403-022-00529-6
Zhao-Feng Guo, Wiebke J. Boeing, Yao-Yang Xu, E. Borgomeo, Dong Liu, Yong-guan Zhu
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引用次数: 0
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