Pub Date : 2023-05-29DOI: 10.1007/s12403-023-00565-w
Sebastian Granitzer, Raimund Widhalm, Simon Atteneder, Mariana F Fernandez, Vicente Mustieles, Harald Zeisler, Markus Hengstschläger, Claudia Gundacker
Brain-derived neurotrophic factor (BDNF) and kisspeptin-1 (KISS-1) regulate placental development and fetal growth. The predictive value of maternal serum BDNF and KISS-1 concentrations for placental and umbilical cord levels has not yet been explored. The influence of prenatal lead (Pb) and cadmium (Cd) exposure and maternal iron status on BDNF and KISS-1 levels is also unclarified and of concern. In a pilot cross-sectional study with 65 mother-newborn pairs, we analyzed maternal and cord serum levels of pro-BDNF, mature BDNF, and KISS-1, BDNF, and KISS-1 gene expression in placenta, Pb and Cd in maternal and umbilical cord blood (erythrocytes), and placenta. We conducted a series of in vitro experiments using human primary trophoblast cells (hTCs) and BeWo cells to verify main findings of the epidemiological analysis. Strong and consistent correlations were observed between maternal serum levels of pro-BDNF, mature BDNF, and KISS-1 and corresponding levels in umbilical serum and placental tissue. Maternal red blood cell Pb levels were inversely correlated with serum and placental KISS-1 levels. Lower expression and release of KISS-1 was also observed in Pb-exposed BeWo cells. In vitro Pb exposure also reduced cellular BDNF levels. Cd-treated BeWo cells showed increased pro-BDNF levels. Low maternal iron status was positively associated with low BDNF levels. Iron-deficient hTCs and BeWo cells showed a consistent decrease in the release of mature BDNF. The correlations between maternal BDNF and KISS-1 levels, placental gene expression, and umbilical cord serum levels, respectively, indicate the strong potential of maternal serum as predictive matrix for BDNF and KISS-1 levels in placentas and fetal sera. Pb exposure and iron status modulate BDNF and KISS-1 levels, but a clear direction of modulations was not evident. The associations need to be confirmed in a larger sample and validated in terms of placental and neurodevelopmental function.
Supplementary information: The online version contains supplementary material available at 10.1007/s12403-023-00565-w.
{"title":"BDNF and KISS-1 Levels in Maternal Serum, Umbilical Cord, and Placenta: The Potential Role of Maternal Levels as Effect Biomarker.","authors":"Sebastian Granitzer, Raimund Widhalm, Simon Atteneder, Mariana F Fernandez, Vicente Mustieles, Harald Zeisler, Markus Hengstschläger, Claudia Gundacker","doi":"10.1007/s12403-023-00565-w","DOIUrl":"10.1007/s12403-023-00565-w","url":null,"abstract":"<p><p>Brain-derived neurotrophic factor (BDNF) and kisspeptin-1 (KISS-1) regulate placental development and fetal growth. The predictive value of maternal serum BDNF and KISS-1 concentrations for placental and umbilical cord levels has not yet been explored. The influence of prenatal lead (Pb) and cadmium (Cd) exposure and maternal iron status on BDNF and KISS-1 levels is also unclarified and of concern. In a pilot cross-sectional study with 65 mother-newborn pairs, we analyzed maternal and cord serum levels of pro-BDNF, mature BDNF, and KISS-1, BDNF, and KISS-1 gene expression in placenta, Pb and Cd in maternal and umbilical cord blood (erythrocytes), and placenta. We conducted a series of in vitro experiments using human primary trophoblast cells (hTCs) and BeWo cells to verify main findings of the epidemiological analysis. Strong and consistent correlations were observed between maternal serum levels of pro-BDNF, mature BDNF, and KISS-1 and corresponding levels in umbilical serum and placental tissue. Maternal red blood cell Pb levels were inversely correlated with serum and placental KISS-1 levels. Lower expression and release of KISS-1 was also observed in Pb-exposed BeWo cells. In vitro Pb exposure also reduced cellular BDNF levels. Cd-treated BeWo cells showed increased pro-BDNF levels. Low maternal iron status was positively associated with low BDNF levels. Iron-deficient hTCs and BeWo cells showed a consistent decrease in the release of mature BDNF. The correlations between maternal BDNF and KISS-1 levels, placental gene expression, and umbilical cord serum levels, respectively, indicate the strong potential of maternal serum as predictive matrix for BDNF and KISS-1 levels in placentas and fetal sera. Pb exposure and iron status modulate BDNF and KISS-1 levels, but a clear direction of modulations was not evident. The associations need to be confirmed in a larger sample and validated in terms of placental and neurodevelopmental function.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12403-023-00565-w.</p>","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":" ","pages":"1-17"},"PeriodicalIF":6.7,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10092381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-26DOI: 10.1007/s12403-023-00566-9
Xiaojie Zou, Yiqin Chen, Ouyang Yang, Shanwen Hu, Ye He, Yan Wu, Wenxiang Wang
{"title":"Assessment Between Follicular Fluid Multiple Element Concentrations and Hormonal Profiles of Women with Polycystic Ovary Syndrome","authors":"Xiaojie Zou, Yiqin Chen, Ouyang Yang, Shanwen Hu, Ye He, Yan Wu, Wenxiang Wang","doi":"10.1007/s12403-023-00566-9","DOIUrl":"https://doi.org/10.1007/s12403-023-00566-9","url":null,"abstract":"","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45087894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-26DOI: 10.1007/s12403-023-00563-y
M. Begum, Litian Li, E. Young, M. Carey, Gang Li, Yong-guan Zhu, Stephen Banwart, A. Meharg, C. Meharg
{"title":"Fertilization Enhances Grain Inorganic Arsenic Assimilation in Rice","authors":"M. Begum, Litian Li, E. Young, M. Carey, Gang Li, Yong-guan Zhu, Stephen Banwart, A. Meharg, C. Meharg","doi":"10.1007/s12403-023-00563-y","DOIUrl":"https://doi.org/10.1007/s12403-023-00563-y","url":null,"abstract":"","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47452106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Long-term atmospheric quality monitoring of fine particulate matter (PM2.5) and PM2.5-bound polycyclic aromatic hydrocarbons (PAHs) was performed in Wuxi from 2016 to 2021. In total, 504 atmospheric PM2.5 samples were collected, and PM2.5-bound 16 PAHs were detected. The PM2.5 and ∑PAHs level decreased annually from 2016 to 2021, from 64.3 to 34.0 μg/m3 and 5.27 to 4.22 ng/m3, respectively. The benzo[a]pyrene (BaP) levels of 42% of the monitoring days in 2017 exceeded the recommended European Union (EU) health-based standard of 1 ng/m3. Five- and six-ring PAHs were found, including benz[a]anthracene, benzo[k]fluoranthene (Bkf), BaP, and benzo[g,h,i]perylene, which were the dominant components (indicating a prominent petroleum, biomass, and coal combustion contribution) using molecular diagnostic ratios and positive matrix factorization analysis. Moreover, PM2.5 and PAHs were significantly negatively associated with local precipitation over a period of six years. Statistically significant temporal and spatial distribution differences of PM2.5, and ∑PAHs were also found. The toxicity equivalent quotient (TEQ) of total PAHs was 0.70, and the TEQ of BaP (0.178) was the highest, followed by that of Bkf (0.090), dibenz[a,h]anthracene (Dah) (0.048), and indeno[1,2,3-cd]pyrene (0.034). The medians of the incremental lifetime cancer risk for long-term exposure to PAHs were 2.74E-8, 1.98E-8, and 1.71E-7 for children, teenagers, and adults, respectively, indicating that the carcinogenic risk of PAHs pollution in air was acceptable to local residents in this area. Sensitivity analysis revealed that BaP, Bkf, and Dah significantly contributed to carcinogenic toxicity. This research provides comprehensive statistics on the local air persistent organic pollutants profile, helps to identify the principal pollution source and compounds, and contributes to the prevention of regional air pollution.
Graphical abstract:
Supplementary information: The online version contains supplementary material available at 10.1007/s12403-023-00572-x.
{"title":"Long-Term Atmosphere Surveillance (2016-2021) of PM<sub>2.5</sub>-bound Polycyclic Aromatic Hydrocarbons and Health Risk Assessment in Yangtze River Delta, China.","authors":"Keqin Wu, Yuyang Yao, Yuanhua Meng, Xuhui Zhang, Run Zhou, Wenwei Liu, Xinliang Ding","doi":"10.1007/s12403-023-00572-x","DOIUrl":"10.1007/s12403-023-00572-x","url":null,"abstract":"<p><p>Long-term atmospheric quality monitoring of fine particulate matter (PM<sub>2.5</sub>) and PM<sub>2.5</sub>-bound polycyclic aromatic hydrocarbons (PAHs) was performed in Wuxi from 2016 to 2021. In total, 504 atmospheric PM<sub>2.5</sub> samples were collected, and PM<sub>2.5</sub>-bound 16 PAHs were detected. The PM<sub>2.5</sub> and ∑PAHs level decreased annually from 2016 to 2021, from 64.3 to 34.0 μg/m<sup>3</sup> and 5.27 to 4.22 ng/m<sup>3</sup>, respectively. The benzo[a]pyrene (BaP) levels of 42% of the monitoring days in 2017 exceeded the recommended European Union (EU) health-based standard of 1 ng/m<sup>3</sup>. Five- and six-ring PAHs were found, including benz[a]anthracene, benzo[k]fluoranthene (Bkf), BaP, and benzo[g,h,i]perylene, which were the dominant components (indicating a prominent petroleum, biomass, and coal combustion contribution) using molecular diagnostic ratios and positive matrix factorization analysis. Moreover, PM<sub>2.5</sub> and PAHs were significantly negatively associated with local precipitation over a period of six years. Statistically significant temporal and spatial distribution differences of PM<sub>2.5</sub>, and ∑PAHs were also found. The toxicity equivalent quotient (TEQ) of total PAHs was 0.70, and the TEQ of BaP (0.178) was the highest, followed by that of Bkf (0.090), dibenz[a,h]anthracene (Dah) (0.048), and indeno[1,2,3-cd]pyrene (0.034). The medians of the incremental lifetime cancer risk for long-term exposure to PAHs were 2.74E-8, 1.98E-8, and 1.71E-7 for children, teenagers, and adults, respectively, indicating that the carcinogenic risk of PAHs pollution in air was acceptable to local residents in this area. Sensitivity analysis revealed that BaP, Bkf, and Dah significantly contributed to carcinogenic toxicity. This research provides comprehensive statistics on the local air persistent organic pollutants profile, helps to identify the principal pollution source and compounds, and contributes to the prevention of regional air pollution.</p><p><strong>Graphical abstract: </strong></p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12403-023-00572-x.</p>","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":" ","pages":"1-14"},"PeriodicalIF":6.7,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10092382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-13DOI: 10.1007/s12403-023-00557-w
Jacopo-Umberto Verga, Costanzo Padovano, W. D. da Silveira, E. Hazard, A. Nugent, C. Elliott, O. Carnevali, R. Galeazzi, G. Hardiman
{"title":"A Systems Biology Approach Reveals the Endocrine Disrupting Potential of Aflatoxin B1","authors":"Jacopo-Umberto Verga, Costanzo Padovano, W. D. da Silveira, E. Hazard, A. Nugent, C. Elliott, O. Carnevali, R. Galeazzi, G. Hardiman","doi":"10.1007/s12403-023-00557-w","DOIUrl":"https://doi.org/10.1007/s12403-023-00557-w","url":null,"abstract":"","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":"1 1","pages":"1-20"},"PeriodicalIF":6.7,"publicationDate":"2023-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41645764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-05DOI: 10.1007/s12403-023-00561-0
Boopathi Subramani, Chia-Huang Chang, Ting-Yu Fang, Ching-Jung Yu, J. Du, Hsien-Chih Chiou, Jianhua Hou, Winnie Yang, Hsin-Chang Chen, Ying-Sheue Chen, B. Hwang,, Mei-Lien Chen
{"title":"The Association of Bisphenol A and Parabens Exposure and Oxidative Stress in Attention-Deficit/Hyperactivity Disorder in Children and Adolescents","authors":"Boopathi Subramani, Chia-Huang Chang, Ting-Yu Fang, Ching-Jung Yu, J. Du, Hsien-Chih Chiou, Jianhua Hou, Winnie Yang, Hsin-Chang Chen, Ying-Sheue Chen, B. Hwang,, Mei-Lien Chen","doi":"10.1007/s12403-023-00561-0","DOIUrl":"https://doi.org/10.1007/s12403-023-00561-0","url":null,"abstract":"","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":"1 1","pages":"1-12"},"PeriodicalIF":6.7,"publicationDate":"2023-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42947499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-05DOI: 10.1007/s12403-023-00558-9
E. Olkowska
{"title":"Permeability of Dimethyl Phthalate Through Human Skin Models – Health Risk Assessment","authors":"E. Olkowska","doi":"10.1007/s12403-023-00558-9","DOIUrl":"https://doi.org/10.1007/s12403-023-00558-9","url":null,"abstract":"","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":"1 1","pages":"1-8"},"PeriodicalIF":6.7,"publicationDate":"2023-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42319635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-04DOI: 10.1007/s12403-023-00562-z
Yongfu Wu, Ning Zhang, Yanhua Shi, Zetao Chen, Han Zhang, Jiaqiang Yin, Tao Zeng, Zhongyu Yuan, Ni Li, Yibin Ren, Liqun Cai, Yunzhao Li, Shengzhong Du
{"title":"PAH Pollution in Particulate Matter and Risk in Chinese Cities","authors":"Yongfu Wu, Ning Zhang, Yanhua Shi, Zetao Chen, Han Zhang, Jiaqiang Yin, Tao Zeng, Zhongyu Yuan, Ni Li, Yibin Ren, Liqun Cai, Yunzhao Li, Shengzhong Du","doi":"10.1007/s12403-023-00562-z","DOIUrl":"https://doi.org/10.1007/s12403-023-00562-z","url":null,"abstract":"","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":"1 1","pages":"1-15"},"PeriodicalIF":6.7,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46845931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-03DOI: 10.1007/s12403-023-00559-8
Zongwen Zhang, Hao Wang, Zheming Shi, Ning Sun
{"title":"Temporal and Spatial Evolution of Groundwater Natural Background Levels in a Rapid Urbanization Area, Northeast of Beijing, China","authors":"Zongwen Zhang, Hao Wang, Zheming Shi, Ning Sun","doi":"10.1007/s12403-023-00559-8","DOIUrl":"https://doi.org/10.1007/s12403-023-00559-8","url":null,"abstract":"","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48486230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-03DOI: 10.1007/s12403-023-00560-1
Qianfeng He, X. Zhang, Lihong Kuang, Haotian Xu, Yizhong Hou, Fangqu Huang, Zeqiong Xu, Hongjie Sun, W. Deng, Hongjun Lin, H. Hong
{"title":"Residues of Polycyclic Aromatic Hydrocarbons in Breast Milk Collected from Jinhua (China) and the Influence of Exercise Habit: Levels and the Potential Health Effects","authors":"Qianfeng He, X. Zhang, Lihong Kuang, Haotian Xu, Yizhong Hou, Fangqu Huang, Zeqiong Xu, Hongjie Sun, W. Deng, Hongjun Lin, H. Hong","doi":"10.1007/s12403-023-00560-1","DOIUrl":"https://doi.org/10.1007/s12403-023-00560-1","url":null,"abstract":"","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":" ","pages":"1-11"},"PeriodicalIF":6.7,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48219113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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