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Long-Term and Multipoint Observations of Atmospheric Heavy Metal (Cu and Cd) Deposition and Accumulation in Soil–Crop System and Human Health Risk Evaluation Around a Large Smelter 大型冶炼厂周边大气重金属(Cu、Cd)在土壤-作物系统中的沉积积累与人体健康风险评价
IF 6.7 3区 环境科学与生态学 Q1 WATER RESOURCES Pub Date : 2023-06-08 DOI: 10.1007/s12403-023-00574-9
Jun Zhou, Hongbiao Cui, Zhengqiu Zhu, Meng-Chao Liu, Rui Xia, Xiaoli Liu, Chengcheng Ding, Jingjing Zhou
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引用次数: 1
Environmental Nickel Exposure and Cardiovascular Disease in a Nationally Representative Sample of U.S. Adults. 美国成年人全国代表性样本中的环境镍暴露与心血管疾病。
IF 6.7 3区 环境科学与生态学 Q1 WATER RESOURCES Pub Date : 2023-06-08 DOI: 10.1007/s12403-023-00579-4
Joshua Cheek, Sara Shuger Fox, Hans-Joachim Lehmler, Tyler J Titcomb

Background: Laboratory studies have linked nickel with the pathogenesis of cardiovascular disease (CVD); however, few observational studies in humans have confirmed this association.

Objective: This study aimed to use urinary nickel concentrations, as a biomarker of environmental nickel exposure, to evaluate the cross-sectional association between nickel exposure and CVD in a nationally representative sample of U.S. adults.

Methods: Data from a nationally representative sample (n = 2702) in the National Health and Nutrition Examination Survey 2017-20 were used. CVD (n = 326) was defined as self-reported physicians' diagnoses of coronary heart disease, angina, heart attack, or stroke. Urinary nickel concentrations were determined by inductively coupled plasma mass spectrometry. Logistic regression with sample weights was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of CVD.

Results: Urinary nickel concentrations were higher in individuals with CVD (weighted median 1.34 μg/L) compared to those without CVD (1.08 μg/L). After adjustment for demographic, socioeconomic, lifestyle, and other risk factors for CVD, the ORs (95% CIs) for CVD compared with the lowest quartile of urinary nickel were 3.57 (1.73-7.36) for the second quartile, 3.61 (1.83-7.13) for the third quartile, and 2.40 (1.03-5.59) for the fourth quartile. Cubic spline regression revealed a non-monotonic, inverse U-shaped, association between urinary nickel and CVD (Pnonlinearity < 0.001).

Conclusions: Nickel exposure is associated with CVD in a non-monotonic manner among U.S. adults independent of well-known CVD risk factors.

Supplementary information: The online version contains supplementary material available at 10.1007/s12403-023-00579-4.

背景:实验室研究已将镍与心血管疾病(CVD)的发病机制联系起来;然而,很少有对人类的观察性研究证实这种联系。目的:本研究旨在使用尿镍浓度作为环境镍暴露的生物标志物,在具有全国代表性的美国成年人样本中评估镍暴露与CVD之间的横断面关联。方法:来自全国代表性样本的数据(n = 2702)。CVD(n = 326)被定义为医生对冠心病、心绞痛、心脏病发作或中风的自我报告诊断。采用电感耦合等离子体质谱法测定尿中镍的浓度。使用样本权重的Logistic回归来估计CVD的优势比(OR)和95%置信区间(CI)。结果:患有CVD的个体的尿镍浓度(加权中位数1.34μg/L)高于没有CVD的个体(1.08μg/L)。在调整了CVD的人口统计学、社会经济、生活方式和其他风险因素后,CVD的OR(95%CI)与尿镍最低四分位数相比,第二个四分位数为3.57(1.73-7.36),第三个四分位为3.61(1.83-7.13),第四个四分位为2.40(1.03-5.59)。三次样条回归揭示了尿镍与CVD之间的非单调、反U型关联(P非线性 结论:在美国成年人中,镍暴露以非单调的方式与CVD相关,与众所周知的CVD风险因素无关。补充信息:在线版本包含补充材料,可访问10.1007/s12403-023-00579-4。
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引用次数: 1
Correction: Potential Factors Associated with the Blood Metal Concentrations of Reproductive-Age Women in Taiwan 更正:台湾育龄妇女血金属浓度之潜在因素
3区 环境科学与生态学 Q1 WATER RESOURCES Pub Date : 2023-06-08 DOI: 10.1007/s12403-023-00571-y
Tsung-Ho Ying, Chun-Jui Huang, Chia-Jung Hsieh, Pei-Ju Wu, Chang-Ching Yeh, Ping-Kun Hung, Wei-Hsiang Chang, Meng-Hsing Wu, Hsin Hung, Jung-Wei Chang, Chen-Tai Wang, Rachelle D. Arcega, Trias Mahmudiono, Ching-Chang Lee, Hsiu-Ling Chen
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引用次数: 1
Analysis of Human Co-exposure to Lead and Cadmium Using Human Biomonitoring (HBM) Data in a Bayesian Copula-Based Regression Framework 基于贝叶斯copula回归框架的人体生物监测(HBM)数据对人体铅镉共暴露的分析
IF 6.7 3区 环境科学与生态学 Q1 WATER RESOURCES Pub Date : 2023-06-07 DOI: 10.1007/s12403-023-00573-w
Moustapha Sy, A. Conrad, Christian Jung, O. Lindtner, M. Greiner
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引用次数: 0
Toxic Effects of Atrazine on Liver and Underlying Mechanism: A Review 阿特拉津对肝脏的毒性作用及其机制综述
IF 6.7 3区 环境科学与生态学 Q1 WATER RESOURCES Pub Date : 2023-06-05 DOI: 10.1007/s12403-023-00575-8
Honghao Qian, Haotang Zhao, Hui Ye, Jianwei Cui, Xiaoqi Fang, Yuezhu Zhang, Lin Ye
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引用次数: 2
In Utero Exposure to Lead is Associated with Neural Tube Defects via Disturbing the Expression of Endocannabinoid Retrograde Signaling-Related Genes 子宫内暴露于铅通过干扰内源性大麻素逆行信号相关基因的表达与神经管缺陷相关
3区 环境科学与生态学 Q1 WATER RESOURCES Pub Date : 2023-06-05 DOI: 10.1007/s12403-023-00564-x
Tian Tian, Huijun Dong, Shengju Yin, Mengyuan Liu, Yongyan Chen, Kuanhui Xiang, Linlin Wang, Jie Qiao, Aiguo Ren
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引用次数: 0
Bacterial Modification of the Association Between Arsenic and Autism-Related Social Behavior Scores. 砷与自闭症相关社会行为评分相关性的细菌修饰。
IF 6.7 3区 环境科学与生态学 Q1 WATER RESOURCES Pub Date : 2023-06-01 Epub Date: 2022-06-22 DOI: 10.1007/s12403-022-00494-0
Hannah E Laue, Yuka Moroishi, Brian P Jackson, Thomas J Palys, Emily R Baker, Susan A Korrick, Juliette C Madan, Margaret R Karagas

Arsenic is related to neurodevelopmental outcomes and is associated with the composition of the gut microbiome. Data on the modifying role of the microbiome are limited. We probed suggestive relationships between arsenic and social behaviors to quantify the modifying role of the infant gut microbiome. We followed children for whom arsenic concentrations were quantified in 6-week-old toenail clippings. Scores on the Social Responsiveness Scale (SRS-2), which measures autism-related social behaviors, were provided by caregivers when the child was approximately 3 years of age. Metagenomic sequencing was performed on infant stools collected at 6 weeks and 1 year of age. To evaluate modification by the top ten most abundant species and functional pathways, we modeled SRS-2 total T-scores as a function of arsenic concentrations, microbiome features dichotomized at their median, and an interaction between exposure and the microbiome, adjusting for other trace elements and sociodemographic characteristics. As compared to the standardized population (SRS-2 T-scores = 50), participants in our study had lower SRS-2 scores (n = 78, mean = 44, SD = 5).The relative abundances of several functional pathways identified in 6-week stool samples modified the arsenic-SRS-2 association, including the pathways of valine and isoleucine biosynthesis; we observed no association among those with high relative abundance of each pathway [β = - 0.67 (95% CI - 1.46, 0.12)], and an adverse association [β = 1.67 (95% CI 0.3, 3.04), pinteraction= 0.05] among infants with low relative abundance. Our findings indicate the infant gut microbiome may alter neurodevelopmental susceptibility to environmental exposures.

砷与神经发育结果有关,并与肠道微生物组的组成有关。关于微生物组的修饰作用的数据是有限的。我们探讨了砷和社会行为之间的暗示关系,以量化婴儿肠道微生物组的调节作用。我们对6周大的脚趾甲剪下的儿童进行了砷浓度的量化随访。照顾者在孩子大约3岁时提供了社会反应量表(SRS-2)的分数,该量表衡量自闭症相关的社会行为。对6周龄和1岁时收集的婴儿粪便进行宏基因组测序。为了评估前十个最丰富的物种和功能途径的修饰,我们将SRS-2总T分数建模为砷浓度、中位数二分的微生物组特征以及暴露和微生物组之间的相互作用的函数,并根据其他微量元素和社会人口特征进行调整。与标准人群(SRS-2 T评分=50)相比,我们研究的参与者的SRS-2评分较低(n=78,平均值=44,SD=5)。在6周粪便样本中发现的几种功能途径的相对丰度改变了砷-SRS-2的关联,包括缬氨酸和异亮氨酸生物合成途径;我们观察到,在每种途径的相对丰度较高的婴儿中没有关联[β=-0.67(95%CI-1.46,0.12)],在相对丰度较低的婴儿中有不良关联[β=1.67(95%CI 0.3,3.04),pinteract=0.05]。我们的研究结果表明,婴儿肠道微生物组可能会改变神经发育对环境暴露的易感性。
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引用次数: 0
BDNF and KISS-1 Levels in Maternal Serum, Umbilical Cord, and Placenta: The Potential Role of Maternal Levels as Effect Biomarker. 母体血清、脐带和胎盘中BDNF和KISS-1水平:母体水平作为效应生物标志物的潜在作用。
IF 6.7 3区 环境科学与生态学 Q1 WATER RESOURCES Pub Date : 2023-05-29 DOI: 10.1007/s12403-023-00565-w
Sebastian Granitzer, Raimund Widhalm, Simon Atteneder, Mariana F Fernandez, Vicente Mustieles, Harald Zeisler, Markus Hengstschläger, Claudia Gundacker

Brain-derived neurotrophic factor (BDNF) and kisspeptin-1 (KISS-1) regulate placental development and fetal growth. The predictive value of maternal serum BDNF and KISS-1 concentrations for placental and umbilical cord levels has not yet been explored. The influence of prenatal lead (Pb) and cadmium (Cd) exposure and maternal iron status on BDNF and KISS-1 levels is also unclarified and of concern. In a pilot cross-sectional study with 65 mother-newborn pairs, we analyzed maternal and cord serum levels of pro-BDNF, mature BDNF, and KISS-1, BDNF, and KISS-1 gene expression in placenta, Pb and Cd in maternal and umbilical cord blood (erythrocytes), and placenta. We conducted a series of in vitro experiments using human primary trophoblast cells (hTCs) and BeWo cells to verify main findings of the epidemiological analysis. Strong and consistent correlations were observed between maternal serum levels of pro-BDNF, mature BDNF, and KISS-1 and corresponding levels in umbilical serum and placental tissue. Maternal red blood cell Pb levels were inversely correlated with serum and placental KISS-1 levels. Lower expression and release of KISS-1 was also observed in Pb-exposed BeWo cells. In vitro Pb exposure also reduced cellular BDNF levels. Cd-treated BeWo cells showed increased pro-BDNF levels. Low maternal iron status was positively associated with low BDNF levels. Iron-deficient hTCs and BeWo cells showed a consistent decrease in the release of mature BDNF. The correlations between maternal BDNF and KISS-1 levels, placental gene expression, and umbilical cord serum levels, respectively, indicate the strong potential of maternal serum as predictive matrix for BDNF and KISS-1 levels in placentas and fetal sera. Pb exposure and iron status modulate BDNF and KISS-1 levels, but a clear direction of modulations was not evident. The associations need to be confirmed in a larger sample and validated in terms of placental and neurodevelopmental function.

Supplementary information: The online version contains supplementary material available at 10.1007/s12403-023-00565-w.

脑源性神经营养因子(BDNF)和kisspeptin-1(KISS-1)调节胎盘发育和胎儿生长。母体血清BDNF和KISS-1浓度对胎盘和脐带水平的预测价值尚未探索。产前铅(Pb)和镉(Cd)暴露以及母体铁状况对BDNF和KISS-1水平的影响也未得到证实和关注。在一项针对65对母婴的初步横断面研究中,我们分析了母体和脐带血清中前BDNF、成熟BDNF以及KISS-1、BDNF和KISS-1基因在胎盘中的表达,母体和脐带血(红细胞)以及胎盘中Pb和Cd的水平。我们使用人类原代滋养层细胞(hTC)和BeWo细胞进行了一系列体外实验,以验证流行病学分析的主要结果。母体血清前BDNF、成熟BDNF和KISS-1的水平与脐带血清和胎盘组织中的相应水平之间存在强烈且一致的相关性。母体红细胞Pb水平与血清和胎盘KISS-1水平呈负相关。在Pb暴露的BeWo细胞中也观察到KISS-1的低表达和释放。体外铅暴露也降低了细胞BDNF水平。Cd处理的BeWo细胞显示出增加的前BDNF水平。母体铁含量低与BDNF水平低呈正相关。缺铁的hTC和BeWo细胞显示出成熟BDNF的释放持续减少。母体BDNF和KISS-1水平、胎盘基因表达和脐带血清水平之间的相关性分别表明,母体血清作为胎盘和胎儿血清中BDNF和KISS-1水平的预测基质具有很强的潜力。铅暴露和铁状态调节BDNF和KISS-1水平,但调节的明确方向并不明显。这种关联需要在更大的样本中得到证实,并在胎盘和神经发育功能方面得到验证。补充信息:在线版本包含补充材料,可访问10.1007/s12403-023-00565-w。
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引用次数: 0
Assessment Between Follicular Fluid Multiple Element Concentrations and Hormonal Profiles of Women with Polycystic Ovary Syndrome 多囊卵巢综合征女性卵泡液多元素浓度与激素谱的关系
IF 6.7 3区 环境科学与生态学 Q1 WATER RESOURCES Pub Date : 2023-05-26 DOI: 10.1007/s12403-023-00566-9
Xiaojie Zou, Yiqin Chen, Ouyang Yang, Shanwen Hu, Ye He, Yan Wu, Wenxiang Wang
{"title":"Assessment Between Follicular Fluid Multiple Element Concentrations and Hormonal Profiles of Women with Polycystic Ovary Syndrome","authors":"Xiaojie Zou, Yiqin Chen, Ouyang Yang, Shanwen Hu, Ye He, Yan Wu, Wenxiang Wang","doi":"10.1007/s12403-023-00566-9","DOIUrl":"https://doi.org/10.1007/s12403-023-00566-9","url":null,"abstract":"","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45087894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fertilization Enhances Grain Inorganic Arsenic Assimilation in Rice 施肥促进水稻籽粒无机砷同化
IF 6.7 3区 环境科学与生态学 Q1 WATER RESOURCES Pub Date : 2023-05-26 DOI: 10.1007/s12403-023-00563-y
M. Begum, Litian Li, E. Young, M. Carey, Gang Li, Yong-guan Zhu, Stephen Banwart, A. Meharg, C. Meharg
{"title":"Fertilization Enhances Grain Inorganic Arsenic Assimilation in Rice","authors":"M. Begum, Litian Li, E. Young, M. Carey, Gang Li, Yong-guan Zhu, Stephen Banwart, A. Meharg, C. Meharg","doi":"10.1007/s12403-023-00563-y","DOIUrl":"https://doi.org/10.1007/s12403-023-00563-y","url":null,"abstract":"","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47452106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
期刊
Exposure and Health
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