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Letter: Incidence and Predictors of Major Gastrointestinal Bleeding in Patients on Aspirin, Low-Dose Rivaroxaban or the Combination: Secondary Analysis of the COMPASS Randomised Controlled Trial. 信阿司匹林、小剂量利伐沙班或联合用药患者重大消化道出血的发生率和预测因素：COMPASS 随机对照试验的二次分析。
IF 6.6 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Alimentary Pharmacology & Therapeutics
Pub Date : 2024-10-05 DOI: 10.1111/apt.18306
Yu Yang, Yaling Li, Jun Li
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引用次数: 0
Letter: Allostatic load and adverse prognosis in inflammatory bowel disease-Need more evidence. 信：炎症性肠病的代谢负荷与不良预后--需要更多证据。
IF 6.6 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Alimentary Pharmacology & Therapeutics
Pub Date : 2024-10-05 DOI: 10.1111/apt.18249
Lingyu Xu, Chen Guan, Long Zhao, Yan Xu
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引用次数: 0
Letter: Allostatic Load and Adverse Prognosis in Inflammatory Bowel Disease-Need More Evidence. Authors' Reply. 信：炎症性肠病的异质负荷和不良预后--需要更多证据。作者回复。
IF 6.6 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Alimentary Pharmacology & Therapeutics
Pub Date : 2024-10-05 DOI: 10.1111/apt.18303
Jianhui Zhao, Erxu Xue, Zhanju Liu, Xue Li
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引用次数: 0
Letter: Incidence and Predictors of Major Gastrointestinal Bleeding in Patients on Aspirin, Low-Dose Rivaroxaban or the Combination: Secondary Analysis of the COMPASS Randomised Controlled Trial. Authors' Reply. 信阿司匹林、小剂量利伐沙班或联合用药患者重大消化道出血的发生率和预测因素：COMPASS 随机对照试验的二次分析。作者回复。
IF 6.6 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Alimentary Pharmacology & Therapeutics
Pub Date : 2024-10-05 DOI: 10.1111/apt.18317
Nauzer Forbes, Jackie Bosch, John W Eikelboom
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引用次数: 0
Editorial: Prediction in Inflammatory Bowel Disease-Do the Answers Lie in Big Clinical Data? 社论：炎症性肠病的预测--临床大数据是否能提供答案？
IF 6.6 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Alimentary Pharmacology & Therapeutics
Pub Date : 2024-10-05 DOI: 10.1111/apt.18301
Zachary Green, James J Ashton
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引用次数: 0
Review article: The role of the gut–brain axis in inflammatory bowel disease and its therapeutic implications 评论文章：肠脑轴在炎症性肠病中的作用及其治疗意义。
IF 6.6 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Alimentary Pharmacology & Therapeutics
Pub Date : 2024-10-05 DOI: 10.1111/apt.18192
Christy Riggott, Alexander C. Ford, David J. Gracie

Background

Treatments targeting the gut–brain axis (GBA) are effective at reducing symptom burden in irritable bowel syndrome (IBS). The prevalence of common mental disorders and IBS-type symptom reporting is significantly higher in inflammatory bowel disease (IBD) than would be expected, suggesting potential GBA effects in this setting. Manipulation of the GBA may offer novel treatment strategies in selected patients with IBD. We present a narrative review of the bi-directional effects of the GBA in IBD and explore the potential for GBA-targeted therapies in this setting.

Methods

We searched MEDLINE, EMBASE, EMBASE Classic, PsychINFO, and the Cochrane Central Register of Controlled Trials for relevant articles published by March 2024.

Results

The bi-directional relationship between psychological well-being and adverse longitudinal disease activity outcomes, and the high prevalence of IBS-type symptom reporting highlight the presence of GBA-mediated effects in IBD. Treatments targeting gut–brain interactions including brain–gut behavioural treatments, neuromodulators, and dietary interventions appear to be useful adjunctive treatments in a subset of patients.

Conclusions

Psychological morbidity is prevalent in patients with IBD. The relationship between longitudinal disease activity outcomes, IBS-type symptom reporting, and poor psychological health is mediated via the GBA. Proactive management of psychological health should be integrated into routine care. Further clinical trials of GBA-targeted therapies, conducted in selected groups of patients with co-existent common mental disorders, or those who report IBS-type symptoms, are required to inform effective integrated models of care in the future.

背景：针对肠-脑轴（GBA）的治疗能有效减轻肠易激综合征（IBS）的症状负担。在炎症性肠病（IBD）中，常见精神障碍和肠易激综合征类症状报告的发生率明显高于预期，这表明肠脑轴在这种情况下具有潜在的作用。操纵 GBA 可为特定的 IBD 患者提供新的治疗策略。我们对 GBA 在 IBD 中的双向作用进行了叙述性综述，并探讨了在这种情况下 GBA 靶向疗法的潜力：我们检索了MEDLINE、EMBASE、EMBASE Classic、PsychINFO和Cochrane对照试验中央注册库中2024年3月之前发表的相关文章：结果：心理健康与纵向疾病活动不良结局之间的双向关系以及肠易激综合征类型症状报告的高发生率凸显了肠易激综合征中存在由 GBA 介导的效应。针对肠-脑相互作用的治疗，包括脑-肠行为治疗、神经调节剂和饮食干预，似乎对部分患者是有用的辅助治疗方法：结论：IBD患者普遍存在心理疾病。纵向疾病活动结果、IBS 型症状报告和不良心理健康之间的关系是通过 GBA 介导的。应将积极的心理健康管理纳入常规护理中。我们需要进一步开展针对GBA疗法的临床试验，这些试验将在选定的同时患有常见精神障碍或报告有IBS类症状的患者群体中进行，以便为未来有效的综合护理模式提供依据。
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引用次数: 0
Editorial: Addressing Unmet Needs and Socioeconomic Disparity in Patients With Autoimmune Hepatitis. 社论：解决自身免疫性肝炎患者未满足的需求和社会经济差异。
IF 6.6 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Alimentary Pharmacology & Therapeutics
Pub Date : 2024-10-05 DOI: 10.1111/apt.18305
Seren Gedallovich, Aparna Goel
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引用次数: 0
Editorial: Distinct Challenges of Paediatric From Adult-Onset Inflammatory Bowel Disease, Implications of Aggressive Disease Phenotypes and Early Biologic Therapy in Children-Authors' Reply. 社论：儿童与成人发病型炎症性肠病的不同挑战、侵袭性疾病表型的影响以及儿童的早期生物疗法--作者的回复。
IF 6.6 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Alimentary Pharmacology & Therapeutics
Pub Date : 2024-10-04 DOI: 10.1111/apt.18310
Maya Granot, Batia Weiss, Yael Haberman
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引用次数: 0
Editorial: Predictive Factors and Survival Outcome of Conversion Therapy for Unresectable Hepatocellular Carcinoma Patients Receiving Atezolizumab and Bevacizumab: Comparative Analysis of Conversion, Partial Response and Complete Response Patients. 社论：接受阿特珠单抗和贝伐单抗治疗的不可切除肝细胞癌患者转换疗法的预测因素和生存结果：转换、部分应答和完全应答患者的比较分析。
IF 6.6 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Alimentary Pharmacology & Therapeutics
Pub Date : 2024-10-04 DOI: 10.1111/apt.18296
Joao Gorgulho, Johann von Felden
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引用次数: 0
Editorial: Predictive Factors and Survival Outcome of Conversion Therapy for Unresectable Hepatocellular Carcinoma Patients Receiving Atezolizumab and Bevacizumab: Comparative Analysis of Conversion, Partial Response and Complete Response Patients. Authors' Reply. 社论：接受阿特珠单抗和贝伐单抗治疗的不可切除肝细胞癌患者转换疗法的预测因素和生存结果：转换、部分应答和完全应答患者的比较分析。作者回复。
IF 6.6 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Alimentary Pharmacology & Therapeutics
Pub Date : 2024-10-04 DOI: 10.1111/apt.18319
Takeshi Hatanaka, Satoru Kakizaki, Atsushi Hiraoka, Toshifumi Tada, Takashi Kumada
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引用次数: 0
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