Alimentary Pharmacology & Therapeutics最新文献

{"title":"Editorial: ‘Risk‐Adapted Starting Ages of Colorectal Cancer Screening for People With Diabetes or Metabolic Syndrome’","authors":"James Turvill","doi":"10.1111/apt.70106","DOIUrl":"https://doi.org/10.1111/apt.70106","url":null,"abstract":"","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":"25 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: ‘Risk‐Adapted Starting Ages of Colorectal Cancer Screening for People With Diabetes or Metabolic Syndrome’. Authors' Reply","authors":"Hermann Brenner, Teresa Seum, Michael Hoffmeister","doi":"10.1111/apt.70111","DOIUrl":"https://doi.org/10.1111/apt.70111","url":null,"abstract":"","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":"183 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Relationship Between Elevated Liver Biochemical Tests and Negative Clinical Outcomes in Primary Biliary Cholangitis: A Population-Based Study","authors":"Kris V. Kowdley, David W. Victor, Joanna P. MacEwan, Radhika Nair, Alina Levine, Jennifer Hernandez, Leona Bessonova, Jing Li, Darren Wheeler, Gideon Hirschfield","doi":"10.1111/apt.70120","DOIUrl":"https://doi.org/10.1111/apt.70120","url":null,"abstract":"Elevated liver biochemistries are associated with increased risk of negative outcomes in patients with primary biliary cholangitis (PBC).","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":"37 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limitations of Faecal Calprotectin in Detecting Histological Changes and Persistent Villous Atrophy in Patients With Coeliac Disease on a Gluten-Free Diet.","authors":"Verónica Segura, Ángela Ruiz-Carnicer, Ángeles Pizarro, Carmen González-Naranjo, Jacobo Díaz, Cristóbal Coronel-Rodríguez, Federico Argüelles-Arias, Marta Garzón-Benavides, Carolina Sousa, Isabel Comino","doi":"10.1111/apt.70114","DOIUrl":"https://doi.org/10.1111/apt.70114","url":null,"abstract":"<p><p>Faecal calprotectin is used to assess intestinal inflammation, but its role in monitoring mucosal healing in coeliac disease is unclear. This study followed 48 adults with coeliac disease on a gluten-free diet over 12 months, evaluating faecal calprotectin levels in correlation with anti-transglutaminase antibodies, gluten-free diet adherence by dietary questionnaires and histology. Although significant histological lesions (Marsh II-III) decreased from 24% to 10%, faecal calprotectin levels fluctuated without correlation to anti-transglutaminase, adherence or histological remission, and did not differentiate between lesion grades. Our findings underscore faecal calprotectin's unreliability in monitoring mucosal healing in adults with coeliac disease, highlighting the urgent need for alternative biomarkers.</p>","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Air Pollution Associated With Mortality Among Chronic Hepatitis B Patients","authors":"Hyo Young Lee, Dae Won Jun","doi":"10.1111/apt.70062","DOIUrl":"https://doi.org/10.1111/apt.70062","url":null,"abstract":"","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":"22 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter: Exclusive Enteral Nutrition in Ulcerative Colitis—The Path Ahead Needs Careful Consideration. Authors' Reply","authors":"Matthew K. W. Chu, Alice S. Day, Lani Broad, Samuel P. Costello, Suzanne Edwards, Robert V. Bryant","doi":"10.1111/apt.70121","DOIUrl":"https://doi.org/10.1111/apt.70121","url":null,"abstract":"","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":"21 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Featured Cover","authors":"Erin R. Bonner,&nbsp;Werner Tschollar,&nbsp;Robert Anderson,&nbsp;Sulayman Mourabit","doi":"10.1111/apt.70117","DOIUrl":"https://doi.org/10.1111/apt.70117","url":null,"abstract":"<p>The cover image is based on the article <i>Review Article: Novel Enzyme Therapy Design for Gluten Peptide Digestion Through Exopeptidase Supplementation</i> by Erin R. Bonner et al., https://doi.org/10.1111/apt.70014 \u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":"61 7","pages":"i"},"PeriodicalIF":6.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apt.70117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of High-Sensitivity Troponins in Metabolic Dysfunction-Associated Steatotic Liver Disease With All-Cause and Cause-Specific Mortality","authors":"Donghee Kim, Pojsakorn Danpanichkul, Karn Wijarnpreecha, George Cholankeril, Aijaz Ahmed","doi":"10.1111/apt.70128","DOIUrl":"https://doi.org/10.1111/apt.70128","url":null,"abstract":"Characterising the phenotypic features of individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) can help identify high-risk subpopulations within this group. High-sensitivity troponin (hs-troponin) is a significant risk factor for future cardiovascular disease events.","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":"37 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter: The Simple Endoscopic Score for Predicting Crohn's Disease Progression—Not as Simple as It Sounds","authors":"Ziheng Calvin Xu, Ethan Tan, Mayur Garg","doi":"10.1111/apt.70108","DOIUrl":"https://doi.org/10.1111/apt.70108","url":null,"abstract":"&lt;p&gt;We read with interest the study by Peraza and colleagues examining the role of the Simple Endoscopic Score for Crohn's Disease (SES-CD) in defining mild Crohn's disease (CD) and predicting the risk of disease progression [&lt;span&gt;1&lt;/span&gt;].&lt;/p&gt;\u0000&lt;p&gt;SES-CD is a well-established endoscopic scoring system used to assess CD severity based on ulcer size, ulcerated surface, affected surface without ulceration and stenosis [&lt;span&gt;2&lt;/span&gt;]. SES-CD correlates with the more extensive Crohn's Disease Endoscopic Index of Severity and faecal calprotectin [&lt;span&gt;3, 4&lt;/span&gt;].&lt;/p&gt;\u0000&lt;p&gt;Peraza et al. performed a retrospective analysis of 177 patients with CD from three major referral centres. They concluded that SES-CD ≥ 7 is an independent predictor of disease progression [&lt;span&gt;1&lt;/span&gt;]. However, several limitations require further consideration.&lt;/p&gt;\u0000&lt;p&gt;The median disease duration at the time of endoscopy was 17 years, meaning that many patients had already declared their risk of progression or non-progression. In a population-based study, the cumulative risk of developing stricturing and/or penetrating complications was approximately 50% at 20 years post-diagnosis [&lt;span&gt;5&lt;/span&gt;]. Despite this extended disease duration in this study, one-third of patients had an SES-CD score of 0 in the absence of current immunomodulator or biologic therapy, bringing the diagnosis of CD into question. How many of these patients had previously been treated with medical therapy for CD? What proportion simply reflects patients with previous isolated terminal ileal aphthous ulcers or ileitis without other evidence for CD, as is commonly encountered in clinical settings? [&lt;span&gt;6&lt;/span&gt;] Hence, the study population may represent a less complex cohort, contrary to the authors' claim of including a more complex patient population.&lt;/p&gt;\u0000&lt;p&gt;Among this cohort, 14% had stricturing and 4% had fistulising disease at baseline. These complications would already classify such patients as moderate-to-severe, having had progression of their disease, and eligible for medical therapy to prevent further complications [&lt;span&gt;7&lt;/span&gt;]. Therefore, inclusion of these patients does little to guide management decisions, particularly given the potential discrepancy between endoscopic and transmural findings in some patients [&lt;span&gt;8&lt;/span&gt;].&lt;/p&gt;\u0000&lt;p&gt;The authors highlighted the advantage of SES-CD in assessing ileal and colonic disease activity separately, noting that an SES-CD ≥ 7 was more predictive of disease progression in ileal and ileocolonic disease than in isolated colonic disease. However, the study did not differentiate patients with small bowel CD or assess the predictive utility of SES-CD in this subgroup. An SES-CD of 4–6 in a patient with isolated ileal CD requires at least one or more of large ulcers (&gt; 5 mm), ulcerated surface &gt; 10%, affected surface &gt; 50%, or narrowing. Hence, these patients would no longer be regarded as having mild disease, as recognised by inclusion criteria ","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":"89 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review Article: Individualised Management of Reflux-Like Symptoms—Strategies Beyond Acid Suppression","authors":"Peter J. Kahrilas, Laurie Keefer, Rena Yadlapati, Foteini Anastasiou, Joel J. Heidelbaugh, Colin W. Howden, Juan M. Mendive, Edoardo Vincenzo Savarino, Mihaela Udrescu, A. Pali S. Hungin","doi":"10.1111/apt.70115","DOIUrl":"https://doi.org/10.1111/apt.70115","url":null,"abstract":"Reflux-like symptoms and reflux oesophagitis are often perceived as having the same acid-related aetiology and responsiveness to antisecretory therapy. However, the frequency of residual symptom reporting on proton pump inhibitor (PPI) therapy suggests the two entities have some differential pathophysiological determinants requiring distinct management approaches.","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":"183 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}