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Patterns of trajectories of glycated hemoglobin, fasting plasma glucose, and body mass index until the first clinic visit: the real-world history of type 2 diabetes using repeated health checkup data of Japanese workers. 首次就诊前糖化血红蛋白、空腹血浆葡萄糖和体重指数的轨迹模式:利用日本工人的重复健康检查数据研究 2 型糖尿病的真实世界病史。
IF 2.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-02-07 DOI: 10.1093/fampra/cmae054
Toshiko Takao, Machi Suka, Masako Nishikawa, Hiroyuki Yanagisawa, Toru Ishii

Background: There is a lack of evidence regarding the trajectories of type 2 diabetes until the first clinic visit, including the untreated period after diagnosis.

Objective: We aimed to determine the real-world history of type 2 diabetes until the first clinic visit, including the untreated duration, and to assess the effective timing of the therapeutic intervention.

Methods: A total of 23,622 nondiabetic Japanese workers with a mean (SD) age of 38.8 (11.5) years were retrospectively followed from 2008 to 2022 for annual health checkups. The trajectories of glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), and body mass index (BMI) until the first clinic visit in diabetes individuals were determined. ROC analysis was performed to assess the contribution of each measure to the first visit.

Results: During a median follow-up of 12.0 years, 1,725 individuals developed type 2 diabetes, of whom 532 individuals visited clinics. HbA1c and FPG trajectories steeply rose in the year before the first clinic visit after their progressive upward trends. ROC analysis showed cutoff values for each measure. As the untreated duration increased, glycemia increased and BMI decreased among individuals who visited clinics.

Conclusions: To prevent the initial worsening of diabetes, early therapeutic intervention is necessary during the increasing trends before the steep rise in glycemia, regardless of the degree of obesity. HbA1c ≥6.5% (47.5 mmol/mol) and an HbA1c ≥0.2% (2.2 mmol/mol)/year increase may be an effective timing for therapeutic intervention.

背景:关于 2 型糖尿病首次就诊前的发展轨迹,包括确诊后的未治疗期,目前尚缺乏相关证据:我们旨在确定 2 型糖尿病在首次就诊前的真实病史,包括未经治疗的时间,并评估治疗干预的有效时间:方法:对 23622 名平均(标清)年龄为 38.8(11.5)岁的非糖尿病日本工人进行了回顾性随访,随访时间为 2008 年至 2022 年的年度体检。研究人员测定了糖尿病患者首次就诊前的糖化血红蛋白(HbA1c)、空腹血浆葡萄糖(FPG)和体重指数(BMI)的变化轨迹。通过 ROC 分析评估了各项指标对首次就诊的影响:中位随访时间为 12.0 年,共有 1725 人罹患 2 型糖尿病,其中 532 人就诊。HbA1c 和 FPG 的变化轨迹在首次就诊前一年呈逐渐上升趋势。ROC 分析显示了各项指标的临界值。随着未治疗时间的延长,就诊者的血糖值升高,体重指数下降:无论肥胖程度如何,为了防止糖尿病初期恶化,在血糖急剧上升之前的上升趋势期间,有必要进行早期治疗干预。HbA1c ≥6.5%(47.5 mmol/mol)和 HbA1c ≥0.2%(2.2 mmol/mol)/年增长可能是治疗干预的有效时机。
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引用次数: 0
Delphi definition of general practice/family medicine specialty for a post-COVID world: in-person and remote care delivery. 德尔菲法定义后 COVID 世界的全科/家庭医学专科:现场和远程医疗服务。
IF 2.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-02-07 DOI: 10.1093/fampra/cmae061
Filipe Prazeres, Marc Jamoulle, Ana Kareli, Claire Collins, Csaba Móczár, Martin C S Wong, Sudip Bhattacharya, Shlomo Vinker, L Leng Low, Suraya Abdul-Razak, Joanne Brooke, Mohamud A Verjee, Hakan Yaman, Pramendra Prasad, Jens Søndergaard, Dimity Pond, Lloyd Hughes, Fatma Goksin Cihan, Zoi Tsimtsiou, Christopher Harrison, Loai Albarqouni, Beibei Yuan, Y Kong Lee, Paul Van Royen, Indiran Govender, Bengt B Arnetz, Catherine A O'Donnell

Introduction: The evolving landscape of general practice (GP)/family medicine (FM) in the post-COVID-19 era, focussing on integrating telemedicine and remote consultations requires a new definition for this specialty. Hence, a broader consensus-based definition of post-COVID-19 GP/FM is warranted.

Methods: This study involved a modified electronic Delphi technique involving 27 specialists working in primary care recruited via convenient and snowball sampling. The Delphi survey was conducted online between August 2022 and April 2023, utilizing the Google Forms platform. Descriptive statistics were employed to analyse consensus across Delphi rounds.

Results: Twenty-six international experts participated in the survey. The retention rate through the second and third Delphi rounds was 96.2% (n = 25). The broader consensus definition emphasizes person-centred care, collaborative patient-physician partnerships, and a holistic approach to health, including managing acute and chronic conditions through in-person or remote access based on patient preferences, medical needs, and local health system organization.

Conclusion: The study highlights the importance of continuity of care, prevention, and coordination with other healthcare professionals as core values of primary care. It also reflects the role of GP/FM in addressing new challenges post-pandemic, such as healthcare delivery beyond standard face-to-face care (e.g. remote consultations) and an increasingly important role in the prevention of infectious diseases. This underscores the need for ongoing research and patient involvement to continually refine and improve primary healthcare delivery in response to changing healthcare landscapes.

导言:后 COVID-19 时代的全科医学(GP)/家庭医学(FM)不断发展,其重点是整合远程医疗和远程会诊,这就要求对该专业进行新的定义。因此,有必要对后 COVID-19 时代的全科医生/全科医学进行更广泛的基于共识的定义:本研究采用了经过修改的电子德尔菲技术,通过方便抽样和滚雪球抽样的方式招募了 27 名从事初级保健工作的专家。德尔菲调查于 2022 年 8 月至 2023 年 4 月期间利用谷歌表格平台在线进行。采用描述性统计方法对德尔菲各轮调查的共识进行了分析:26 位国际专家参与了调查。第二轮和第三轮德尔菲的保留率为 96.2%(n = 25)。更广泛的共识定义强调以人为本的护理、患者与医生之间的合作关系以及整体健康方法,包括根据患者的偏好、医疗需求和当地医疗系统的组织情况,通过亲临现场或远程访问来管理急性和慢性疾病:这项研究强调了医疗服务的连续性、预防以及与其他医疗专业人员的协调作为初级医疗核心价值的重要性。研究还反映了全科医生/全科医疗在应对大流行后的新挑战方面所发挥的作用,如提供标准面对面医疗服务以外的医疗服务(如远程会诊),以及在预防传染病方面发挥日益重要的作用。这突出表明,有必要持续开展研究并让患者参与进来,以不断完善和改进初级医疗保健服务,应对不断变化的医疗保健环境。
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引用次数: 0
"Evolution of a combined baccalaureate/medical degree program as a pipeline to primary care: retention strategies and lessons learned". "学士/医学联合学位课程作为初级保健渠道的演变:保留策略和经验教训"。
IF 2.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-02-07 DOI: 10.1093/fampra/cmae066
Sushilla Z Knottenbelt, Marlene P Ballejos, Diana Torrez, Richard Santos, Rebecca S Hartley, Kate Cartwright, Sally A Fortner, Robert E Sapién, Valerie Romero-Leggott

Background: The University of New Mexico School of Medicine established the combined baccalaureate/medical degree (BA/MD) program in response to critical physician shortages in New Mexico (NM). This 8-year program aims to improve health care in NM by expanding access to medical education for local students, particularly from rural and underserved communities and/or racial/ethnically underrepresented in medicine (URiM) in NM.

Objectives: To describe the BA/MD program's initial design, the impact of improvements on retention, and the outcomes in terms of physicians in practice, particularly in primary care specialties.

Methods: The study reviews the BA/MD program's progress from 2006 to 2023, focusing on curriculum and support enhancements. Retention rates and choice of primary care specialties were analyzed by geographic origin and racial/ethnic background.

Results: From 2006 to 2023, the program graduated 81 physicians, with 53 practicing in 10 of NM's 33 counties. Approximately two-thirds specialize in primary care, and a similar proportion are URiM. Students from 31 of NM's 33 counties were admitted, with two-thirds coming from outside the state's metropolitan area. Overall retention and retention across demographic groups improved significantly in the baccalaureate phase of the program due to changes in curriculum and support services.

Conclusions: The program has effectively addressed physician shortages in NM, particularly in rural and underserved areas. Its success in training and retaining physicians from diverse backgrounds, with a focus on primary care, is crucial for improving health care access in the state. Ongoing improvements in the program are essential to sustaining and enhancing these outcomes.

背景:新墨西哥大学医学院为应对新墨西哥州(NM)严重的医生短缺问题,设立了学士/医学联合学位(BA/MD)项目。该项目为期 8 年,旨在通过扩大当地学生接受医学教育的机会来改善新墨西哥州的医疗服务,尤其是来自新墨西哥州农村和医疗服务不足的社区和/或在医学领域代表性不足的种族/族裔(URiM)的学生:目的:描述医学学士/医学博士项目的最初设计、改进对学生保留率的影响,以及医生在实践中的成果,尤其是在初级保健专业方面:研究回顾了文学士/医学博士项目从 2006 年到 2023 年的进展情况,重点关注课程和支持方面的改进。结果:从 2006 年到 2023 年,该专业的学生留校率和对初级医疗专业的选择均有所提高:从 2006 年到 2023 年,该项目共培养了 81 名医生,其中 53 名医生在北墨 33 个县中的 10 个县执业。约有三分之二的学生专门从事初级保健,而 URiM 的比例也与此相当。录取的学生来自新墨西哥州 33 个县中的 31 个,其中三分之二来自该州大都市以外的地区。由于课程和支持服务的改变,该项目在学士学位阶段的总体保留率和不同人口群体的保留率都有显著提高:结论:该项目有效地解决了北马里亚纳州医生短缺的问题,尤其是在农村和医疗服务不足的地区。该计划成功地培训和留住了来自不同背景的医生,并将重点放在初级保健上,这对改善该州的医疗服务至关重要。不断改进该计划对于保持和提高这些成果至关重要。
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引用次数: 0
The presentation and treatment of Dupuytren's disease in Dutch general practitioner care. 荷兰全科医生对杜普伊特伦氏病的介绍和治疗。
IF 2.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-02-07 DOI: 10.1093/fampra/cmae065
Roel J M van Straalen, Dieuwke C Broekstra, Paul M N Werker, Michiel R de Boer

Background: When research and management of Dupuytren's disease (DD) shift from symptom relief to preventing contractures, general practitioner (GP) care may become more central to treatment. However, the presentation and course of DD in GP care are underexplored and this has been recognized as a knowledge gap that hinders effective treatment decisions. This study is the first to map the trajectory of DD patients in GP care.

Methods: Using electronic health records from Dutch general practices in a regional research network, we conducted a registration-based cohort study in a dynamic population. Descriptive statistics detailed patient demographics, number of contacts, and symptoms per contact. The time and number of contacts before diagnosis were also analysed. Sankey diagrams illustrated the relationship between management options and symptoms.

Results: Over a 16-year period, 84% of patients with a DD diagnosis had visited their GP for this reason, with 73% only having one GP contact. The diagnosis was made at first contact for 93% of patients. Initial contacts often reported a lump (57.3%), but this symptom was less frequent in subsequent visits. 'Daily life impairment' increased after the first contact. The most common management options were referral to secondary care (37.7%) and watchful waiting (35.1%).

Conclusion: The diagnosis and management of DD in GP care are in line with the current guidelines. Less than half of the DD patients were referred to secondary care during follow-up. This may give room for preventive treatment that limits progression. Future studies should focus on the accuracy of diagnosis and the feasibility of effective treatments in GP care.

背景:当对杜普伊特伦氏病(DD)的研究和管理从缓解症状转向预防挛缩时,全科医生(GP)护理可能会成为治疗的核心。然而,人们对全科医生护理中的杜普伊特伦氏病表现和病程探索不足,这已被认为是阻碍有效治疗决策的知识空白。本研究首次绘制了DD患者在全科医生护理中的病程轨迹:方法:我们利用区域研究网络中荷兰全科医生的电子健康记录,对动态人群进行了基于登记的队列研究。描述性统计详细描述了患者的人口统计学特征、接触次数和每次接触的症状。我们还分析了确诊前的接触时间和次数。桑基图说明了治疗方案与症状之间的关系:在 16 年间,84% 的 DD 诊断患者曾因此就诊于全科医生,其中 73% 的患者只接触过一次全科医生。93%的患者在首次就诊时就得到了诊断。初次就诊的患者通常会报告有肿块(57.3%),但这种症状在随后的就诊中出现的频率较低。首次就诊后,"日常生活障碍 "有所增加。最常见的处理方案是转诊至二级医疗机构(37.7%)和观察等待(35.1%):结论:全科医生对 DD 的诊断和管理符合现行指南。结论:全科医生对 DD 的诊断和处理符合现行指南的要求。在随访过程中,不到一半的 DD 患者被转诊至二级医疗机构。这可能为限制病情发展的预防性治疗提供了空间。今后的研究应重点关注全科医生护理中诊断的准确性和有效治疗的可行性。
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引用次数: 0
Expanding the primary care workforce by integrating genetic counselors in multidisciplinary care teams. 通过将遗传咨询师纳入多学科护理团队,扩大初级保健人员队伍。
IF 2.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-02-07 DOI: 10.1093/fampra/cmae057
Rachel Vanneste, Sasha A Bauer, Kennedy Borle, Erika Dreikorn

Collectively, rare diseases are common, affecting approximately 8% of the population in Canada and the USA. Therefore, the majority of primary care (PC) clinicians will care for patients who are affected or at risk for a genetic disease. Considering the increasing ways in which genetics is being implemented into all areas of healthcare, one way to address these needs and expand the capacity of the PC workforce is through the integration of genetic counselors (GCs) into PC multidisciplinary teams. GCs are Masters-educated allied health professionals with specialized training in molecular genetics, communication, and short-term psychotherapeutic counseling. The current models of GCs in PC mimic other multidisciplinary models. Complex tasks related to genetics, such as pre- and post-test counseling, genetic test selection, and results interpretation, are conducted by GCs, which, in turn, allows physicians, nurse practitioners, and other PC providers to work at the top of their scope of practice. Quality genetics services provided by GCs improve clinical outcomes for patients and their families; the simultaneous provision of genetic education and psychological support by a GC is associated with an increase in patient knowledge, perceived personal control, decrease in distress, and can lead to positive health behavior changes, all of which are aligned with the goals of primary healthcare. With their extensive training in clinical care, medical communication, and psychotherapeutic counseling, integrating GCs into PC care teams will improve the care patients receive and allow PC clinicians to ensure their patients are at the forefront of the personalized medicine revolution.

总的来说,罕见病是一种常见病,在加拿大和美国约有 8% 的人口患有罕见病。因此,大多数初级保健 (PC) 临床医生都会照顾受遗传病影响或有遗传病风险的患者。考虑到遗传学正以越来越多的方式应用于医疗保健的各个领域,满足这些需求并扩大初级保健人员队伍能力的一种方法是将遗传咨询师(GCs)纳入初级保健多学科团队。遗传咨询师是受过分子遗传学、沟通和短期心理治疗咨询专业培训的硕士学位专职医疗人员。目前 PC 中的遗传咨询师模式与其他多学科模式类似。与遗传学有关的复杂任务,如检测前后咨询、基因检测选择和结果解释等,均由遗传学专家完成,这反过来又使医生、执业护士和其他 PC 医疗服务提供者能够在其执业范围内开展工作。遗传学家提供的优质遗传学服务可改善患者及其家属的临床治疗效果;遗传学家同时提供遗传学教育和心理支持,可增加患者的知识,提高其个人控制能力,减少痛苦,并可促使其改变积极的健康行为,所有这些都与初级医疗保健的目标相一致。遗传学家在临床护理、医学沟通和心理治疗咨询方面接受过广泛的培训,将他们纳入 PC 护理团队将改善患者获得的护理,并使 PC 临床医生能够确保他们的患者处于个性化医疗革命的前沿。
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引用次数: 0
Enhancing the role of general practitioner trainers in supporting antibiotic stewardship initiatives. 加强全科医生培训师在支持抗生素管理举措中的作用。
IF 2.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-02-07 DOI: 10.1093/fampra/cmae058
Waseem Jerjes
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引用次数: 0
Are we ready? assessing effectiveness and implementation of cancer control strategies in primary care: a comprehensive review of systematic reviews.
IF 2.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-02-07 DOI: 10.1093/fampra/cmae078
Javiera Martinez-Gutierrez, María Gabriela Soto, Andrea Rioseco, Catalina Bienzobas, Madeline Fowler, Gonzalo Ulloa, Mauricio Soto, Jon David Emery, Klaus Puschel

Background: Cancer is a major global cause of death, and primary care is crucial for cancer prevention and early detection. However, there is conflicting information on the effectiveness, implementation, and sustainability of cancer control interventions in primary care.

Objective: This study aimed to summarize the evidence for cancer control in primary care, focussing on identifying relevant factors for implementation and sustainability.

Study setting and design: We conducted a narrative, mixed-methods review of systematic reviews, guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Four databases were screened, and two independent reviewers selected studies reporting on cancer prevention, screening, or early detection in primary or community settings. We analysed findings using the extended Reach-Effectiveness-Adopt-Implementation-Maintenance (RE-AIM) Framework.

Principal findings: From the 37 reviews that met the inclusion criteria, 6 focussed on primary prevention, 23 on screening, and 12 on early detection. Most reviews (78%) addressed intervention effectiveness, such as HPV vaccination, tobacco cessation, and cervical, breast, and colorectal screening. One-third of the reviews mentioned adoption and implementation factors, including barriers and facilitators to the implementation of cancer screening programs. Only one review addressed maintenance and sustainability factors, exploring continuous resources and funding strategies.

Conclusion: While numerous interventions are effective for cancer prevention and detection in primary care, literature on implementation and sustainability strategies is lacking. Focusing on continuous resources and funding for cancer strategies in primary care may aid sustainability. Future research should prioritize reporting on implementation and sustainability factors to enhance cancer prevention and control in primary care settings.

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引用次数: 0
Correction to: A 2-item version of the Japanese Consultation and Relational Empathy measure: a pilot study using secondary analysis of a cross-sectional survey in primary care. 更正:日本咨询与关系移情测量法的 2 个项目版本:利用初级医疗横断面调查的二次分析进行的试点研究。
IF 2.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-02-07 DOI: 10.1093/fampra/cmae060
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引用次数: 0
Variation in general practitioners' follow-up of depressed patients starting antidepressant medication: a register-based cohort study. 全科医生对开始服用抗抑郁药物的抑郁症患者的随访差异:一项基于登记的队列研究。
IF 2.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-02-07 DOI: 10.1093/fampra/cmae063
Anneli B Hansen, Øystein Hetlevik, Valborg Baste, Inger Haukenes, Tone Smith-Sivertsen, Sabine Ruths

Background: Guidelines recommend follow-up within 2 weeks for patients starting medication for depression. Knowledge is lacking about how general practitioners' (GPs) follow-up varies with patients' sociodemographic characteristics.

Objective: To describe follow-up by GP and specialist in mental healthcare provided to men and women with depression within 3 months of starting drug therapy. Furthermore, to examine whether follow-up varied according to patients' age and education.

Methods: Registry-based cohort study comprising all patients aged ≥18 years in Norway with a new depression episode in 2014 who started on antidepressants within 12 months from diagnosis. Patients' age and educational level were the exposures. Outcomes were follow-up by GP and/or mental healthcare specialist, and talking therapy with GP, within 90 days of first prescription. Cox proportional hazard models were used to estimate the likelihood of having follow-up contacts. Log binomial regression analysis was performed to explore the likelihood of having talking therapy with a GP. Time to first contact was illustrated by Kaplan-Meier survival curves.

Results: The study population comprised 17 000 patients, mean age 45.7 years, 60.6% women. Only 27.8% of the patients were followed up by GP and/or specialist within 2 weeks of the first drug dispensing, 67.1% within 90 days. Older or less educated men and women received less and later contacts than the younger or more highly educated.

Conclusions: Differences in age and educational level were associated with follow-up of depressed patients who started medication. This may indicate unwarranted variation in depression care that GPs should consider when prescribing antidepressants.

背景:指南建议在两周内对开始接受药物治疗的抑郁症患者进行随访。关于全科医生(GPs)的随访如何随患者的社会人口特征而变化,目前还缺乏相关知识:目的:描述全科医生和心理保健专家在开始药物治疗后 3 个月内对男性和女性抑郁症患者的随访情况。此外,研究随访是否随患者的年龄和教育程度而变化:方法:基于登记的队列研究,包括挪威所有年龄≥18岁、2014年新发抑郁症并在确诊后12个月内开始服用抗抑郁药物的患者。患者的年龄和受教育程度为暴露因子。结果为首次处方后90天内由全科医生和/或心理保健专家进行的随访,以及与全科医生进行的谈话治疗。采用 Cox 比例危险模型来估算进行后续联系的可能性。对数二项式回归分析用于探讨与全科医生进行谈话治疗的可能性。卡普兰-梅耶生存曲线显示了首次接触的时间:研究对象包括 17 000 名患者,平均年龄 45.7 岁,60.6% 为女性。只有 27.8% 的患者在首次配药后 2 周内接受了全科医生和/或专科医生的随访,67.1% 的患者在 90 天内接受了随访。年龄较大或受教育程度较低的男性和女性比年龄较小或受教育程度较高的男性和女性获得的联系更少、更晚:结论:年龄和教育水平的差异与开始接受药物治疗的抑郁症患者的随访有关。这可能表明,全科医生在开具抗抑郁药物处方时,应考虑到抑郁症护理中不必要的差异。
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引用次数: 0
Correction to: Methodological quality and clinical recommendations of guidelines on the management of dyslipidaemias for cardiovascular disease risk reduction: a systematic review and an appraisal through AGREE II and AGREE REX tools. 更正:降低心血管疾病风险的血脂异常管理指南的方法学质量和临床建议:通过 AGREE II 和 AGREE REX 工具进行的系统综述和评估。
IF 2.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-02-07 DOI: 10.1093/fampra/cmae055
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引用次数: 0
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Family practice
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