European Surgical Research最新文献

英文中文

Value of the Crowd-Sourced Assessment of Technical Skills (C-SATS) Platform in Surgical Procedures: A Systematic Review of Evidence 技术技能众包评估(C-SATS)平台在外科手术中的价值:证据的系统回顾

IF 1.6 4区医学 Q2 SURGERY

European Surgical Research

Pub Date : 2022-12-31 DOI: 10.33425/2689-1093.1047

Tommaselli Giovanni A, Sehat Alvand J, Ricketts Crystal D, Ć. W., Grange Philippe

Background: Crowd-Sourced Assessment of Technical Skills (C-SATS) is a surgical data management and learning platform that leverages the knowledge of large expert surgeon and lay groups to assess the technique and technical skills of surgeons in a highly efficient manner. The aim of this systematic review was to summarize published literature on the performance of C-SATS as compared to expert evaluations and assess its use as a training and validation tool in minimally invasive surgery (MIS). Methods: A comprehensive literature search was performed per PRISMA guidelines using the Medline, Embase, and Google Scholar databases on published studies that evaluated the use of C-SATS following MIS, such as laparoscopic or robotic-assisted surgery. Results: A total of 21 reports were included in the review. Twelve studies comparing crowd-sourcing evaluations against expert opinion indicated overall excellent or good correlation with Global Operative Assessment of Laparoscopic Skills (GOALS), Global Evaluative Assessment of Robotic Skills (GEARS), and Robotic Objective Structured Assessment of Technical Skills (R-OSATS) scores, with correlation coefficients (Pearson or Spearman) ranging from 0.69 to 0.95 and reliability index (Cronbach’s alpha) from 0.63 to 0.93 across different specialties and surgical approaches. When using C-SATS to assess performance and validation, assessments positively correlated with traditional methods of time and error-based scoring and global rating scale. Conclusions: Based on the current published literature, the C-SATS platform has been shown to efficiently provide crowd-sourced evaluations that correlate favorably with expert evaluation across a range of surgical specialties and approaches. Use of crowdsourcing has uniformly yielded accurate evaluations of surgeons’ technical skills in a markedly shorter time than expert reviews. C-SATS may be a cost-effective complement or alternative to traditional models of evaluating surgical proficiency. Future studies are needed to determine whether the use of C-SATS will lead to improved surgical performance and patient outcomes.

背景:C-SATS (Crowd-Sourced Assessment of Technical Skills)是一个外科数据管理和学习平台，利用大型专家外科医生和非专业群体的知识，高效地评估外科医生的技术和技能。本系统综述的目的是总结已发表的关于C-SATS性能的文献，并将其与专家评估相比较，并评估其作为微创手术(MIS)培训和验证工具的用途。方法:根据PRISMA指南，使用Medline, Embase和Google Scholar数据库对已发表的研究进行全面的文献检索，这些研究评估了MIS后C-SATS的使用，如腹腔镜或机器人辅助手术。结果:共纳入21篇报道。12项比较众包评估与专家意见的研究表明，总体上与腹腔镜技能全局手术评估(GOALS)、机器人技能全局评估评估(GEARS)和机器人客观结构化技术技能评估(R-OSATS)得分的相关性良好或良好。不同专科和手术入路的相关系数(Pearson或Spearman)在0.69 ~ 0.95之间，可靠性指数(Cronbach’s alpha)在0.63 ~ 0.93之间。当使用C-SATS评估性能和验证时，评估与传统的基于时间和错误的评分方法和全局评分量表呈正相关。结论:根据目前发表的文献，C-SATS平台已被证明可以有效地提供众包评估，与一系列外科专科和手术方法的专家评估相关联。与专家评估相比，使用众包技术可以在更短的时间内对外科医生的技术技能做出准确的评估。C-SATS可能是评估手术熟练程度的传统模型的一种具有成本效益的补充或替代方法。需要进一步的研究来确定使用C-SATS是否会改善手术效果和患者预后。

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引用次数: 1

Regulation of FOXO3 on neuronal ferroptosis after intracerebral hemorrhage via modulating NOX4 transcription. FOXO3通过调控NOX4转录对脑出血后神经元铁凋亡的调节作用

IF 1.6 4区医学 Q2 SURGERY

European Surgical Research

Pub Date : 2022-11-15 DOI: 10.1159/000527617

Zhongzong Qin, Gang Zhu, Honghai Luo, Yifan Deng

Introduction: Intracerebral hemorrhage (ICH) is known to trigger neuronal ferroptosis while forkhead box O3 (FOXO3) is implicated in ICH. This study aimed to determine the specific effect of FOXO3 on neuronal ferroptosis after ICH.

Methods: The ICH mouse model was established through the injection of bacterial collagenase type IV and the cell model was established in Hemin-induced HT-22 cells. Subsequently, neurological functions, brain water content, and histopathological changes in mice were assessed. HT-22 cell activity was examined via cell counting kit-8 (CCK-8) method, and the levels of FOXO3, NADPH oxidase 4 (NOX4), and glutathione peroxidase 4 (GPX4) in brain tissues and HT-22 cells were measured. Fe2+ concentration and the levels of reactive oxygen species (ROS), malondialdehyde (MDA), and glutathione (GSH) in the tissues and cells were examined. The binding relationship between FOXO3 and the NOX4 promoter region was determined via chromatin-immunoprecipitation (Ch-IP). Rescue experiments were designed to probe the role of NOX4 in the regulation of FOXO3 on neuronal ferroptosis.

Results: FOXO3 was highly-expressed in ICH models while silencing FOXO3 alleviated brain damage, edema, and inflammatory infiltration in ICH mice. Meanwhile, silencing FOXO3 enhanced cell activity, diminished ROS and MDA activities and Fe2+ concentration, and elevated GSH and GPX4 levels in the tissues or cells. FOXO3 could bind to the NOX4 promoter and upregulate NOX4 transcription. NOX4 overexpression partially neutralized the repressive role of silencing FOXO3 in neuronal ferroptosis.

Conclusion: Silencing FOXO3 attenuated ICH-induced neuronal ferroptosis via down-regulating NOX4 transcription levels, thus ameliorating post-ICH brain damage.

导言：已知脑出血（ICH）会引发神经元铁凋亡，而叉头盒O3（FOXO3）与ICH有关。本研究旨在确定 FOXO3 对 ICH 后神经元铁突变的具体影响：方法：通过注射细菌胶原酶 IV 型建立 ICH 小鼠模型，并在 Hemin 诱导的 HT-22 细胞中建立细胞模型。随后，对小鼠的神经功能、脑含水量和组织病理学变化进行了评估。通过细胞计数试剂盒-8（CCK-8）法检测了 HT-22 细胞的活性，并测定了脑组织和 HT-22 细胞中 FOXO3、NADPH 氧化酶 4（NOX4）和谷胱甘肽过氧化物酶 4（GPX4）的水平。还检测了组织和细胞中的 Fe2+ 浓度以及活性氧（ROS）、丙二醛（MDA）和谷胱甘肽（GSH）的水平。通过染色质免疫沉淀（Ch-IP）确定了 FOXO3 与 NOX4 启动子区域的结合关系。拯救实验旨在探究 NOX4 在 FOXO3 对神经元铁凋亡的调控中的作用：结果：FOXO3 在 ICH 模型中高表达，而沉默 FOXO3 可减轻 ICH 小鼠的脑损伤、水肿和炎症浸润。同时，沉默 FOXO3 能增强细胞活性，降低 ROS 和 MDA 活性及 Fe2+ 浓度，提高组织或细胞中 GSH 和 GPX4 的水平。FOXO3 能与 NOX4 启动子结合并上调 NOX4 的转录。NOX4的过量表达部分中和了沉默FOXO3在神经元铁变态反应中的抑制作用：结论：沉默FOXO3可通过下调NOX4转录水平减轻ICH诱导的神经元铁凋亡，从而改善ICH后的脑损伤。

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引用次数: 0

Front & Back Matter 正面和背面事项

IF 1.6 4区医学 Q2 SURGERY

European Surgical Research

Pub Date : 2022-09-01 DOI: 10.1159/000526881

引用次数: 0

Effects of Bromelain on Noradrenaline Release During Anxiety-Like Behaviour Following Intra-Medial Forebrain Bundle 6-OHDA Injection in Rat Model of Parkinsonism 菠萝蛋白酶对帕金森大鼠前脑束内注射6-OHDA后焦虑样行为中去甲肾上腺素释放的影响

IF 1.6 4区医学 Q2 SURGERY

European Surgical Research

Pub Date : 2022-06-30 DOI: 10.33425/2689-1093.1043

T. Adu, O. Adu, M. Mabandla

Introduction: Parkinson’s disease (PD) is characterized by emotional dysfunction which is a typical manifestation of non-motor symptoms. Non-motor symptoms may occur simultaneously with motor impairment in PD. Anxiety is a comorbidity in PD. This study therefore addresses the question of whether prior/post 6-OHDA lesion treatment with bromelain can show an effect on the behavioural signs of parkinsonism and damage to the CNS noradrenergic system in experimental rats. Methods: Open field and despair swim tests were used to assess certain psychomotor functions and emotional reactivity in the neurotoxin injected rats. The level of noradrenaline in certain regions of the brain as well as in the blood was further analyzed by enzyme linked immunosorbent assay. Findings: The results showed that unilateral injection of the neurotoxin into the rats’ medial forebrain bundle caused a decrease in the rearing time and a corresponding increase in the time spent grooming. There was a further indication that 6-OHDA injection resulted in the reduction of noradrenaline in the systemic environment. Also, the duration of immobility was increased by 6-OHDA injection but not statistically significant. Pretreatment with bromelain caused a change in the grooming behaviour not consistent with noradrenaline level. Conclusion: This finding suggests that bromelain treatment interferes with the regulation of mood and emotion during the early phase of parkinsonism in the 6-OHDA rat model of PD which was accompanied by changes in noradrenaline level.

帕金森氏病(PD)以情绪功能障碍为特征，是非运动症状的典型表现。PD患者的非运动症状可能与运动障碍同时发生。焦虑是帕金森病的一种共病。因此，本研究解决了用菠萝蛋白酶治疗6-OHDA病变前后是否能对实验大鼠帕金森病的行为体征和中枢神经系统去甲肾上腺素能系统损伤产生影响的问题。方法:采用开阔场试验和绝望游泳试验对神经毒素注射后大鼠的某些精神运动功能和情绪反应性进行评价。用酶联免疫吸附法进一步分析了大脑某些区域和血液中去甲肾上腺素的水平。结果表明，单侧在大鼠内侧前脑束内注射神经毒素，可使饲养时间缩短，梳洗时间相应增加。进一步的研究表明，6-OHDA注射导致全身环境中去甲肾上腺素的减少。注射6-OHDA后，静止时间增加，但无统计学意义。菠萝蛋白酶预处理引起了与去甲肾上腺素水平不一致的梳理行为的改变。结论:本研究提示菠萝蛋白酶干预6-OHDA大鼠帕金森病模型早期情绪和情绪的调节，并伴有去甲肾上腺素水平的改变。

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引用次数: 0

The Management of Hepatocellular Carcinoma at the Kara Teaching Hospital (Togo) 多哥卡拉教学医院肝细胞癌的治疗

IF 1.6 4区医学 Q2 SURGERY

European Surgical Research

Pub Date : 2022-06-30 DOI: 10.33425/2689-1093.1041

Ossouvi Tamegnon, EL-HADJI Yakoubou, Rafiou, Adabra Komlan, Bouglouga Oumboma, Kanassoua Kokou, Kassegne Irokoura, D. David

Objective: To describe the epidemiological, diagnostic, therapeutic and evolutionary aspects of hepatocellular carcinoma at CHU Kara. Method: This is a retrospective study conducted over a period of 3 years in the Department of General Surgery and Hepato-Gastroenterology of CHU-Kara (Togo). Were included in our study all patients, aged over 15 years old hospitalized for hepatocellular carcinoma. Results: We recorded 98 cases out of 7237 hospitalized patients, i.e. a frequency of 1.4%. The patients were consisted of 65 men and 33 women with a sex ratio (F/M) of 0.5. The average age was 49 years old. Clinically, painful hepatomegaly was found in all cases; abdominal pain in all cases, poor general condition in 86 patients; collateral venous circulation in 3 cases. Alpha-fetoprotein (AFP) was above 400 ng/ml in all patients. Abdominal imaging revealed diffuse liver involvement in 85 patients (86.7%), a localized nodular appearance in 13 cases (13.3%).All these patients had received symptomatic treatment combining analgesics and antispasmodics. The mortality rate was 97.9% within 12 months. Conclusion: Hepatocellular carcinoma remains a serious condition and its diagnosis is often difficult. It poses a real problem of care in our developing countries.

目的:了解楚卡拉地区肝细胞癌的流行病学、诊断、治疗和演变情况。方法:这是一项为期3年的回顾性研究，在CHU-Kara(多哥)的普通外科和肝消化内科进行。我们的研究纳入了所有年龄在15岁以上因肝细胞癌住院的患者。结果:7237例住院患者中，我们记录了98例，即1.4%的频率。男性65例，女性33例，性别比(F/M)为0.5。平均年龄为49岁。临床均表现为肝肿大疼痛;所有病例腹痛，86例一般情况较差;侧支静脉循环3例。所有患者甲胎蛋白(AFP)均在400 ng/ml以上。腹部影像学显示85例(86.7%)患者肝脏弥漫性受累，13例(13.3%)患者出现局部结节。所有患者均给予镇痛和抗痉挛药物联合对症治疗。12个月内死亡率为97.9%。结论:肝细胞癌仍然是一种严重的疾病，其诊断往往很困难。这给发展中国家的医疗保健带来了真正的问题。

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引用次数: 1

Primary Diffuse Large B-Cell Lymphoma of the Colon with Spontaneous Perforation: A Case Report 结肠原发性弥漫性大b细胞淋巴瘤伴自发性穿孔1例

IF 1.6 4区医学 Q2 SURGERY

European Surgical Research

Pub Date : 2022-06-30 DOI: 10.33425/2689-1093.1042

Mehdi Hammemi, M. Hajri, S. Omrani, W. Ferjaoui, D. Bacha, B. Rached, Hafedh Mestir

We report a rare case of primary lymphoma of the colon with spontaneous perforation in A 54-year-old woman.

我们报告一例罕见的原发性结肠淋巴瘤并发自发性穿孔的54岁妇女。

引用次数: 0

Bilateral Pudendal Thigh Flap In The Creation of A Neovagina and Restoration of Utero-Neovaginal Continuity – A Case Report 双侧阴部大腿皮瓣再造新阴道及恢复子宫-新阴道连续性1例报告

IF 1.6 4区医学 Q2 SURGERY

European Surgical Research

Pub Date : 2022-06-30 DOI: 10.33425/2689-1093.1040

K. Ogundipe, Elizabeth Evelyn Enoch

The pudendal thigh flap is a sensate flap based on the posterior labial artery, which has shown great versatility in the reconstruction of genital anomalies as well as genital oncologic reconstruction. This report showcases the creation of a neovagina with the restoration of uterovaginal continuity in a 12-year-old girl who had vaginal atresia. She presented with concealed menstruation and cyclical abdominal pain and had a creation of a neovagina with utero-vaginal continuity using a bilateral pudendal thigh fascio-cutaneous flap. Post-operatively, she attained normal menstrual flow and a sensate neovagina with a satisfactory vaginal canal depth. Partial wound dehiscence of the flap donor site was managed with dressing and healing by secondary intention. Even in new centres, the pudendal thigh flap remains a versatile flap for managing vaginal atresia.

阴部股皮瓣是一种以唇后动脉为基础的感觉皮瓣，在生殖器畸形重建和生殖器肿瘤重建中显示出很大的通用性。本报告展示了一个12岁的女孩谁有阴道闭锁子宫阴道连续性的恢复创造一个新的阴道。她表现为隐蔽性月经和周期性腹痛，并使用双侧阴部大腿筋膜皮瓣创造了子宫阴道连续性的新阴道。术后，患者月经流量正常，新阴道感觉良好，阴道管深度满意。皮瓣供区部分创面裂开采用二次创面敷料处理。即使在新的中心，阴部大腿皮瓣仍然是一个多功能皮瓣的管理阴道闭锁。

引用次数: 0

Quality of Information in YouTube Videos on Penis Enlargement Surgery 关于阴茎增大手术的YouTube视频信息质量

IF 1.6 4区医学 Q2 SURGERY

European Surgical Research

Pub Date : 2022-06-30 DOI: 10.33425/2689-1093.1039

Perçin Karakol, Tuncay Taş

Background: An increasing number of patients and their aesthetic curiosity are causing the online questioning of penis enlargement surgery (PES). Although there is a wealth of healthcare information about PES on the internet, the quality of PES-related information on YouTube, the most visited online video streaming service, has not fully known. It is aimed to evaluate the quality of information about PES in YouTube videos. Materials and Methods: In January 2021, we cross-sectionally performed YouTube search using the keywords "penis enlargement surgery", "penis lengthening surgery", or "penis thickening surgery". We sorted the videos as reliability in terms of containing scientifically proven information by 1 urologist and 1 plastic surgeon. Irrelevant, non-Turkish, and silent videos were not included. Video demographics were analyzed based on the quality and source of the video. A 5-point global quality scale, a 5-point reliability (DISCERN) tool, kappa statistic, the intraclass correlation coefficient, and descriptive statistics in the form of proportions and percentages were used. Results: A total of one-hundred PES videos published on YouTube between 2015-2021 were searched. Thirty-nine of these videos were removed due to duplicate, irrelevant, lack of sound or misleading information. Deceptive videos had a significantly higher number of likes than useful videos. On the other hand, useful videos had significantly more views than misleading videos. Useful videos had a higher DISCERN score compared to misleading videos. The fact that the uploader was sourced by professionals and doctors working at universities significantly contributed to the usefulness of the videos. Conclusion: As searching for information about PES on YouTube, patients are exposed to low-quality and confusing videos. Complexity in the number of views and likes could make accessing the informative PES video difficult. It may be recommended that patients prefer PES videos created by professionals.

背景:越来越多的患者和他们的审美好奇心引起了网上对阴茎增大手术(PES)的质疑。尽管互联网上有大量关于PES的医疗信息，但在访问量最大的在线视频流媒体服务YouTube上，PES相关信息的质量尚不完全清楚。它旨在评估YouTube视频中关于PES的信息质量。材料与方法:2021年1月，我们在YouTube上横断面搜索关键词“阴茎增大手术”、“阴茎延长手术”或“阴茎增厚手术”。我们根据1名泌尿科医生和1名整形外科医生的科学证明信息对视频进行了可靠性排序。不相关的、非土耳其的和无声的视频不包括在内。根据视频的质量和来源对视频进行人口统计分析。采用了5点整体质量量表、5点信度(DISCERN)工具、kappa统计、类内相关系数和以比例和百分比形式表示的描述性统计。结果:共检索到2015-2021年间在YouTube上发布的100个PES视频。其中39个视频因重复、不相关、缺乏声音或误导性信息而被删除。欺骗性视频的点赞数明显高于有用视频。另一方面，有用视频的浏览量明显高于误导性视频。与误导视频相比，有用视频的DISCERN得分更高。事实上，上传者的来源是在大学工作的专业人士和医生，这极大地促进了视频的有用性。结论:在YouTube上搜索PES相关信息时，患者所接触到的视频质量较低且容易混淆。观看次数和喜欢次数的复杂性可能会使访问内容丰富的PES视频变得困难。建议患者选择专业人士制作的PES视频。

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引用次数: 0

Front & Back Matter 正面和背面

IF 1.6 4区医学 Q2 SURGERY

European Surgical Research

Pub Date : 2022-06-01 DOI: 10.1159/000525322

引用次数: 0

139th Congress of the German Society of Surgery (DGCH) 德国外科学会（DGCH）第139届大会

IF 1.6 4区医学 Q2 SURGERY

European Surgical Research

Pub Date : 2022-04-01 DOI: 10.1159/000523908

引用次数: 0

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